Árpád Farkas’s extended professional CV
Education
University diploma : Physics, Babes-Bolyai University, Romania, 1996
MSc : Solid State Physics, Babes-Bolyai University/Louis Pasteur University, Romania/France, 1999
PhD, Summa Cum Laude: Biophysics, ELTE University, Hungary, 2008
Other schools & courses
2001-
2004: Postgraduate School in Biophysics, Eötvös Loránd Unversity, Budapest
2002: FLUENT CFD course, Sheffield, UK
2005: FLUENT CFD turbulence modelling course, Porto Carras, Greece
2008: Low dose school, Braunschweig, Germany
2011: EU Training course on modelling low dose radiation effects, Pavia, Italy
Professional, scientific experience
1995 – 1996, ITIM Cluj Research Centre, Romania.
Application of different X-ray techniques for the determination of crystal structures
1998
– 1999, IPCMS Strasbourg, France
Application of NMR techniques for the characterisation of Co nanoparticles embedded in SIO
2
matrix
2000 – Centre for Energy Research (named Atomic Energy Research Institute of Budapest until 2012)
(graduate research assistant: 2001-2005; research associate: 2005-2008; postdoctoral research associate: 2008-2014; senior research fellow: 2014-)
Simulation of deposition, clearance and health effects of the inhaled radio-aerosols by computational fluid and particle dynamics methods
Awards, fellowships
Junior Prize of the Hungarian Academy of Sciences (2005)
Euratom Grant (2005)
Fermi Young Scientist Award (2008)
Euratom grant (2008)
Magyary Zolt
án Fellowship (2013-2014)
Professional Society Membership
EURADOS the European Radiation Dosimetry Group
The Aerosol Society (UK), member of International Aerosol Research Assembly (IARA) and the
European Aerosol Assembly (EAA)
Roland Eötvös Physical Society
Hungarian Nuclear Society
Public Body of the Hungarian Academy of Sciences
Projects
Hungarian projects: OTKA T030571, OTKA T034564, NKFP-3/005/2001, NKFP-1/008/2001, NKFP-3/A-
089/2004, NKFP-1/B-047/2004, GVOP-3.1.1.-2004-05-0432/3.0, K61193 OTKA, ETT 317-08,
KTIA_AIK_12-1-2013-0106204
EU projects: FIGH-CT-1999-00012, CEC 016987 FI6R, EUREKA OMFB-445/2007
Bilateral projects: Austrian-Hungarian Bilateral Projects A-8/98 and A-3/02
Publications
1 book chapter and a total of 123 publications in archival scientific journals and conference proceedings books. Number of full papers is 29, while the number of independent citations: 250, yielding a HIRSCH index of 9
A few relevant papers will be presented here:
● The following review article about therapeutic aerosol transport and deposition in the respiratory system was an invited paper in Jornal of Aerosol Medicine and Pulonary Drug Delivery (written to a call of prof. Ted
Martonen of the University of North Carolina, editor of the journal) and attracted 44 citations so far:
Farkas Á, Balásházy I & Szőcs K: Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods. J. Aerosol Med. 19: 329-
343, 2006.

● Árpád Farkas was a co-author of a paper in which the exact mathematical description of the geometry of airway bifurcations has been provided. The geometry model defined here has been used by many of the investigators peforming CFD computations within the airways. Th article has received 49 citations to date.
Hegedűs CsJ, Balásházy I & Farkas Á: Detailed mathematical description of the geometry of airway bifurcations. Resp. Physiol. Neurobiol .
141: 99-114, 2004.
● The following article was selected by Elsevier in a top of most cited articles of the journal between 2007-
2010. Number of citations: 29 .
Farkas Á & Balásházy I: Simulation of the effect of local obstructions and blockage on airflow and aerosol deposition in central human airways. J. Aerosol Sci. 38: 865-884, 2007.
● The following publication has been selected in the top 10 list of best publications of year 2009 in Journal of
Radiological Protection.
Bal
ásházy I, Farkas Á, Madas BG & Hofmann W: Non-linear reationship of cell hit and transformation probabilities in low dose of inhaled radom progenies. J. Radiol. Prot. 29: 147-162, 2009.
● The following article, was one of the first papers quantifying the particle deposition in multi-generation asymmetric airways. In addition, it was the first paper of the literature providing exhalatory deposition enhancement factors for particles with different diameters in the large bronchial airways. It received 32 citations up to this moment.
Farkas Á & Balásházy I: Quantification of particle deposition in asymmetrical tracheobronchial model geometry. Comp. Biol. Med .
38: 508-518, 2008.
● Other articles from the last three years, with the researcher as a co-author:
Szőke et al.: Stochastic aspects of primary cellular consequences of radon inhalation. Radiat. Res. 171: 96-
106, 2009.
Balásházy et al.: Simulation and minimisation of airway deposition of airborn bacteria. Inhal. Toxicol.
21:
1021-1029, 2009.
Madas et al.: Cellular burdens and biological effects on tissue level caused by inhaled radon progenies.
Radiat Prot Dosim 143: 253-257, 2010.
Horv
áth et al.: Quantification of airway deposition of intact and fragmented pollens. Int J Environ Health Res doi:10.1080/09603123.2011.574269, 2011.
Farkas et al.: Effect of site-specific bronchial radon progeny deposition on the spatial and temporal depositions of cellular responses. Radiat Environ Biophys 50:281-297, 2011.
Sz őke et al.: 3D-modelling of radon-induced cellular radiobiological effects in bronchial airway bifurcations:
Direct versus bystander effects. Int. J. Radiat. Biol. 88:477-492, 2012.
A full list of publications can be found here: https://vm.mtmt.hu/search/slist.php?inited=1&co_on=1&ty_on=1&la_on=&if_on=1&st_on=&url_on=1&cite_ty pe=2&orderby=-
7&Scientific=1&top10=&lang=1&location=&debug=&stn=1&AuthorID=10001968&DocumentID=
Further relevant information
• Árpád Farkas has attended over 30 conferences with many of them in areas related to the topic of the present proposal.
• He was the referee of articles submitted to different journals in the fields of aerosol physics, lung modelling and fluid and particle dynamics. Examples of journals inviting the researcher to review such articles:
Computers in Biology and Medicine, Journal of Aerosol Science, Journal of Biomechanics, Journal of
Aerosol Medicine and Pulmonary Drug Delivery, International Journal for Numerical Methods in Fluids .
Arpad Farkas was an Erasmus fellow at IPCMS (Materials Physics and Chemistry Research Institute)
Strasbourg in 1999 and a EURATOM fellow in 2005 (CEC 016987 FI6R).

Research results
The researcher has several achievements in the field of computer modelling, aerosol physics, and radiation biophysics. Three of his major accomplishments are summarised in the next short description.
•
He quantified the local burden of radon progenies in the central airways at different exposure levels. The results were published in three full papers, conference proceedings and in the PhD thesis of the researcher .
For this accomplishment the researcher was awarded the Junior Prize of the Hungarian Academy of
Sciences .
• The researcher was granted a EURATOM fellowship in 2005 (CEC contract number 016987 FI6R). In the frame of this fellowship the researcher joined an integrated EU project (FI6R-CT-2003-508842). He integrated their microdosimetric model with the state vector model of carcinogenesis into a biophysical based complex risk model of radon induced cancer. The model is able to quantify the risks associated with radon progeny inhalation at different radiation exposure levels. The results were published in the final report, conference proceedings and journal articles. For this achievement the researcher was selected in top 80
Excellent Young Researchers by ERAB (European Research Area Board).
•
The researcher applied for the Fermi Young Scientist Award in 2008. The title of the proposal was
Computer Modeling of transport, deposition and health effects of radon progenies . The application was successful. A speech with the same title was given by the researcher at the award ceremony.
● He developed equations for the description of the so-called morphologically realistic airway bifurcation unit. Based on this description he developed numerical surface generation techniques and applied them to construct the 3D airway geometries.
● In this geometries, he solved the airflow and particle trajectory equations at various breathing parameters and boundary conditions.
● He analysed expiratory deposition patterns in the first five airway generations leading to the right upper lobe of the human lung. The material was presented on a poster at the IRPA 2001 Conference in Dubrovnik, receiving the Best Poster Presentation Award.
● He simulated the effect of airway narrowing and blockage in diseased lungs on particle deposition. He found that the deposition efficiency in case of an airway blockage or strong constriction may increase by a factor of 10 in the 0.1-1 micrometer diameter particle size range in the large central airways, where the deposition efficiency has a minimum (less than 1%) in a healthy lung. Thus, radioactive aerosols of this size are much more dangerous for people with lung disease than for healthy subjects.
● He developed a numerical alveolus deposition model, deriving the equations of computational mesh dynamics in case of an expanding-contracting alveolus. He concluded that the airflow configuration in the alveolar region is different from a pipe flow field and the deposition is very sensitive to the particle sizes, and gravitational orientations. Deposition results were compacted into multiparameter deposition equations.
● He computed the turbulent airflow field and deposition patterns of therapeutic aerosols in the upper airways. He was invited to publish a review article in this topic (Journal of Aerosol Medicine, see the list of publications).
● He performed radon progeny deposition and risk assessment simulations for uranium miners. The results were published in International Journal of Radiation Biology and in Radiation Research journals.
● He took part in the development of an in vitro cell irradiation system. The device is successfully used in
Hungary and Portugal.