BatchNo:2012/08/B2 Makerere University College of Health Sciences (MakCHS). Grant and Contracts Unit. Checklist of Requirements for Request for Funding List of Requirements Funding Opportunity Human Heredity and Health in Title , Activity code, Africa (H3Africa): Collaborative FOA number and Centers (U54), RFA-RM-12-006, Funding Instrument and PHS 398 Application Guide Applications (RFA) for the Month of August 2012. Summary of RFAs Human Heredity and Health in Human Heredity and Health in Africa (H3Africa): H3Africa Africa (H3Africa): H3Africa Biorepository Grants. Research Grants (U01), RFA(UH2/UH3), RFA-RM-12-008 and RM-12-007, and SF 424 (R&R) SF 424 (R&R) 2.Funding Source NIH NIH To develop an H3Africa Biorepository in order to provide an international site for the receipt, storage and distribution of samples from H3Africa research projects as well as other African research studies. To invite applications from Institutions in African countries for Research Projects (U01 cooperative agreements) that address one or more goals of the Human Heredity and Health in Africa (H3Africa) initiative. NIH 3.FOA Purpose To support multi-project research programs that address the goals of H3Africa and that involve two or more collaborations with investigators from outside the applicant institution. 4.Research Objectives To support cutting-edge genomics/genetics research on health and diseases important in Africa, To increase the human resources for conducting cutting-edge genomicsbased research in Africa, and To improve specific types of infrastructure, i.e., bioinformatics and biorepository capacity, which are needed to do genomics-based and environmental research. 1 Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01), PA-12-271 and SF 424 (R&R) NIH To support research projects (R01) that include small-scale physiologic studies in humans or secondary analyses of data and/or stored biospecimens from controlled clinical intervention studies, to increase our understanding about the clinical translational potential of metformin to delay deleterious aging changes or to extend healthy human life span. List of Requirements Funding Opportunity Title , Activity code, FOA number and Funding Instrument Human Heredity and Health in Africa (H3Africa): Collaborative Centers (U54), RFA-RM-12-006, and PHS 398 Application Guide Summary Human Heredity and Health in Africa (H3Africa): H3Africa Biorepository Grants. (UH2/UH3), RFA-RM-12-008 and SF 424 (R&R) of RFAs Human Heredity and Health in Africa (H3Africa): H3Africa Research Grants (U01), RFARM-12-007, and SF 424 (R&R) August 22, 2012 August 22, 2012 August 22, 2012 August 24, 2012 September 28, 2012 September 28, 2012 January 5, 2013 September 28, 2012 September 28, 2012 September 28, 2012 Not Applicable. Jane L. Peterson, Ph.D. h3africa@mail.nih.gov Louise Wideroff, Ph.D., MSPH h3africa@mail.nih.gov Jane L. Peterson, Ph.D h3africa@mail.nih.gov October 29, 2012 Applications are limited to $1,000,000 total costs October 29, 2012, Up to $125,000 total costs per year for the first two years, is allowed for Phase I October 29, 2012, Limited to $350,000 total costs per year February 5, 2013 Application budgets are not limited, but need to reflect actual needs of the proposed project. 4 Year maximum 5 Year maximum Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01), PA-12-271 and SF 424 (R&R) 5.Priority Research Areas 6.Posted date and Earliest Submission date 7.Letter of Intent due date 8.Application due date 9.Award Budget For the Phase II period the budget is limited to $2 million total costs in FY15 and $1.7 million total costs in FY16-18. 10.Award Project Period 4 Year maximum 6 Year maximum 2 List of Requirements Funding Opportunity Title , Activity code, FOA number and Funding Instrument Human Heredity and Health in Africa (H3Africa): Collaborative Centers (U54), RFA-RM-12-006, and PHS 398 Application Guide Summary Human Heredity and Health in Africa (H3Africa): H3Africa Biorepository Grants. (UH2/UH3), RFA-RM-12-008 and SF 424 (R&R) 11.Required Registrations Valid DUNS number required for Central Contractor Registration (CCR), Grants.gov and eRA Commons registration Valid DUNS number required for Central Contractor Registration (CCR), Grants.gov and eRA Commons registration Valid DUNS number required for Central Contractor Registration (CCR), Grants.gov and eRA Commons registration Valid DUNS number required for Central Contractor Registration (CCR), Grants.gov and eRA Commons registration 12.Eligible Individuals Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support Questions regarding Grants.gov registration and submission support@grants.gov Questions regarding Grants.gov registration and submission support@grants.gov Questions regarding Grants.gov registration and submission support@grants.gov Questions regarding Grants.gov registration and submission support@grants.gov SF424 (R&R) Application and Electronic Submission Information:http://grants.nih.gov/gr ants/funding/424/index.htm SF424 (R&R) Application and Electronic Submission Information:http://grants.nih.gov/gr ants/funding/424/index.htm SF424 (R&R) Application and Electronic Submission Information:http://grants.nih.gov/ grants/funding/424/index.htm SF424 (R&R) Application and Electronic Submission Information:http://grants.nih.gov/gra nts/funding/424/index.htm General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceip t/. General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ Grants.gov (http://www.grants.gov) Open Grants.gov (http://www.grants.gov) Open Grants.gov (http://www.grants.gov Open Grants.gov (http://www.grants.gov) 13.Caution 14.Application contact details 15.Full application details 16.Status of application Key DUNS - Dun and Bradstreet Universal Numbering System 3 of RFAs Human Heredity and Health in Africa (H3Africa): H3Africa Research Grants (U01), RFARM-12-007, and SF 424 (R&R) Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01), PA-12-271 and SF 424 (R&R) Open FOA - Funding Opportunity Announcement LMIC – Low Medium Income Countries NCD-Non Communicable Diseases F&A – Facility and Administration PrEP- Pre-exposure Prophylaxis PEPFAR - President’s Emergency Plan for AIDS Relief RFA – Request for Applications R01 – Round one …… etc R&R – Research and research related projects RU - Individual Research Units NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases NIDA - National Institute on Drug Abuse NIGMS- National Institute of General Medical Sciences NIDDK-National Institute of Diabetes and Digestive and Kidney Diseases 4