British Society for Investigative Dermatology Annual Meeting
The University of Newcastle, April 7th-9th, 2014
Programme and Abstracts
Monday 7th April
12.45
Trainee lecture
Professor Irene Leigh
Title TBC
13.30
Lunch
14.00
Welcome: Frank Nestle, Chair BSID
BSID Skin Club Symposium
Chairpersons: Penny Lovat & Nick Reynolds
Epigenetics
14.05
Professor Vardhman Rakyan, Blizard Institute, Barts and The London School of Medicine and
Dentistry
Promise and Pitfalls of Epigenome wide association approaches
14.40
Professor Panos Deloukas, William Harvey Research Institute, Barts and The London School of
Medicine and Dentistry
The Genetics of global DNA methylation patterns in multiple tissues from twins
15.15
Dr Jordana Bell, Kings College London
Epigenetics in skin ageing
15.50
Tea/Coffee
16.20
Professor Vladimir Botchkarev, University of Bradford
Title TBC
16.55
BSID Medal Lecture
Psoriasis is not an autoimmune disease
Professor Lionel Fry
17.35- 19.00
Welcome reception, poster session & commercial exhibition
19.30
Dinner
Hancock Museum
Tuesday 8th April
Scientific Session A – Chairpersons: Andy South & Edel O’Toole
08.30 O1
Topical formulation of polo-like kinase 1 inhibitors for the treatment of human cutaneous
squamous cell carcinoma
C. Pourreyron, S. Wright, S. Watt, I. Leigh and A. South
08.43 O2
Human basal cell carcinoma demonstrates telogen arrest
A. BenKetah, P. Bowden, S. Reed and G. Patel
08.56 O3
Diverse roles for laminin-332 subunits in squamous cell carcinoma
M. Caley, V. Martins, K. Moore, J. Marshall and E. O’Toole
09.09 O4
The development of cutaneous squamous lesions in patients treated with vemurafenib:
investigation of a possible role for human papillomavirus in addition to activated RAS
K. Purdie, A. South, M. Sommerlad, H. Rizvi, I. Leigh, C. Proby and C. Harwood
09.22 O5
Characterization of peritumoral regulatory T cells in cutaneous squamous cell carcinomas
C. Lai, R. Behar, M. Polak, M. Ardern-Jones, J. Theaker, A. Al-Shamkhani and E. Healy
09.35 O6
Cannabinoids hijack the autophagy pathway to promote melanoma cell death
J. Armstrong, C. McKee, D. Hill, G. Velasco and P. Lovat
09.48 O7
Transforming growth factor--mediated Ambra-1 downregulation in melanoma ulceration and
metastasis
R. Ellis, M.-E. Anagnostou, S. Verykiou, M. Elias, S. Horswell, N. Kirkham and P. Lovat
10.01 O8
Prognostic significance of CXCR4 expression in cutaneous melanoma
A. McConnell, R. Ellis, G. O’Boyle, R. Plummer, S. Verykiou and P. Lovat
10.14
Tea/coffee
Scientific Session B – Chairpersons: Helen Young & Graham Ogg
10.45 O9
Human circulating B cells express skin-homing receptors and accumulate within the skin at sites
of infectious and neoplastic inflammation
I.U. Egbuniwe, W. Alwan, M.H. Rustin, A.N. Akbar, S.N. Karagiannis, F.O. Nestle and K.E.
Lacy
10:58 O10
A novel phosphatidylinositol-3-kinase inhibitor decreases activation of ribosomal protein S6 in
psoriatic T cells
N. Yager, C. Haddadeen, A. Payne, R. Allen and E. Healy
11.11 O11
The molecular mechanisms of modulation of human Langerhans cell function by epidermal
cytokines
M.E. Polak, C.Y. Ung, J. Masapust, E. Healy, T. Freeman and M. Ardern-Jones
11.24 O12
Cis-urocanic acid reduces the expression of monocyte-derived dendritic cell costimulatory
molecules in a dose-dependent manner
C. Leitch, C. Yu, J. Schwarze, S. Howie and R. Weller
11.37 O13
Enhanced expression of interleukin (IL)-17, IL-10 and IL-1 in hidradenitis suppurativa
G. Kelly, C.M. Sweeney, R. Fitzgerald, A. Lally, A.M. Tobin and B. Kirby
11.50 O14
Guttate psoriasis is associated with impaired epidermal Langerhans cell migration
L.H. Eaton, L. Chularojanamontri, F.R. Ali, E. Theodorakopoulou, R.J. Dearman, I. Kimber and
C.E.M. Griffiths
12.03 O15
Histamine enhances keratinocyte-mediated resolution of inflammation by promoting wound
healing and response to infection
D. Gutowska-Owsiak, T.A. Selvakumar, M. Salimi, S. Taylor and G.S. Ogg
12.16 O16
The role of type 2 innate lymphoid cells in the pathogenesis of atopic dermatitis
M. Salimi, J. Barlow, S. Saunders, L. Xue, D. Gutowska-Owsiak, X. Wang, L.-C. Huang, D.
Johnson, S. Scanlon, A. McKenzie, P. Fallon and G. Ogg
12.30
Keynote Guest Lecture
Atopic dermatitis in the emerging era of personalised medicine
Professor Thomas Bieber
13.10
Lunch
14:00
Annual General Meeting
Scientific Session C – Chairpersons: Sara Brown & Mark Birch-Machin
15.00 O17
Clock genes PER1 and ARNTL modulate human hair follicle melanogenesis
J. Hardman, I. Haslam, Y. Al-Nuaimi, B. Grimaldi, D. Tobin and R. Paus
15.13 O18
Melanin reduces acute mitochondrial superoxide generation: a real-time amperometric study
S.J. Boulton and M. Birch-Machin
15.26 O19
Altered BRAF signalling is not necessarily associated with BRAF V600E mutations in either adult
or childhood Langerhans cell histiocytosis
J. Selway, P. Harikumar, A. Chu and K. Langlands
15.39 O20
Dense genotyping and human leucocyte antigen imputation identifies two novel loci in late-onset
psoriasis
H.L. Hebert, J. Bowes, R.L. Smith, R. Parslew, A. Alsharqi, E. Flynn, N.J. McHugh, J.N.W.N.
Barker, C.E.M. Griffiths, A. Barton1 and R.B. Warren
15.52 O21
The effects of narrowband ultraviolet B (311 nm) phototherapy on epidermal barrier and
differentiation markers in polymorphic light eruption
E.J. Pond, C.A. O’Neill, L.E. Rhodes and N.K. Gibbs
16.05
British Photodermatology Group Guest Lecture
Professor Thomas Schwarz
Title TBC
16.45 – 18:15
Poster session & commercial exhibition with tea and coffee
18.30- 19:30
Drinks with the Committee for SpR’s, PhD students, Post Docs and THESIS
Suite 4, Jury’s Inn
19:30
Pre-dinner drinks
Discovery Museum
20.00
Annual dinner
Discovery Museum
Wednesday 9th April
Scientific session D – Chairpersons: Ryan O'Shaughnessy & Rachel Watson
08.30 O22
Molecular surgery for epidermolysis bullosa simplex
M. Aushev, C. Mussolino, T. Cathomen, H. Torma and J. Reichelt
08.43 O23
Characterization of SPINK5-transduced keratinocytes under good manufacturing practice
conditions for Netherton syndrome
A. Petrova, W.-L. Di, W. Qasim, L. Chan, F. Farzaneh, A. Thrasher and J. Harper
08.56 O24
Induction of dermal papilla properties in highly potent CD271+CD90+ mesenchymal stem cells
generated from human-induced pluripotent stem cells
O. Veraitch, Y. Mabuchi, Y. Matsuzaki, M. Amagai, H. Okano and M. Ohyama
09.09 O25
Lysophosphatidic acid-mediated signalling during human epidermal keratinocyte migration
D. Johnson, C. Jahoda and N. Reynolds
09.22 O26
Hidradenitis suppurativa: haploinsufficiency of -secretase components does not affect -secretase
enzyme activity in vitro
A. Pink, D. Dafou, N. Desai, O. Holmes, C. Smith, P. Mortimer, M. Simpson. R. Trembath and
J. Barker
09.35 O27
The sebaceous gland as a cycling skin appendage
E. Hinde, I. Haslam, M. Schneider, T. Reis-Matos, A. Imanishi, K. Kawai, J. Kloepper and
R. Paus
09.48 O28
Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes
S. Marsh, V. Martins, M. Caley, M. Barnes, M. Donaldson and E. O’Toole
10.01
Special Guest Lecture
Professor Manabu Ohyama
Title TBC
10.26
Tea/coffee
Scientific session E – Chairpersons: Mike Ardern-Jones & Charlotte Proby
11.00 O29
The role of store-operated calcium entry in epidermal wound healing responses
L. Mottram, M. Begg and N. Reynolds
11.13 O30
Sclerostin domain containing 1 downregulation is required for altered transforming growth factor responsiveness and increased cell migration in linear morphoea fibroblasts
S. Brown, L. Weibel, B. Way, J. Harper and R. O’Shaughnessy
11.26 O31
Parakeratosis causes profound changes in epidermal terminal differentiation
A. Naeem, B. Verney, S. Marmiroli and R. O’Shaughnessy
11.39 O32
Modelling melanoma metastasis using organotypic skin equivalent and zebrafish models
D. Hill, S. Verykiou, N. Robinson, S. Przyborski, J. Armstrong, B. Chaudhry and P. Lovat
11.52 O33
Dissecting the regulation of the inactive rhomboid protein 2/ADAM17 pathway in keratinocyte
differentiation and barrier function
A. Chikh, M. Brooke, S. Etheridge and D. Kelsell
12.05 O34
Mutations in the grainyhead-like 2 transcription factor result in a novel autosomal recessive
ectodermal dysplasia syndrome
G. Petrof, A. Nanda, M.A. Simpson, T. Takeichi, J. McMillan, L. Ozoemena, R. Begum, H. AlAjmi, M. Parsons and J.A. McGrath
12.20
Distinguished Local Lecture
DNA testing on the spot
Professor Sir John Burn
13.00
Prizes and close of meeting
13.15
Lunch