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Course and Workshop Basic and Translational Endocrinology
15-19 April, 2013
Organizers:
Erica van den Akker, Leo Hofland, Robin Peeters, Jenny Visser, Frank
van Vliet
Participants: Postgraduates, Post docs and other interested participants of the
Postgraduate Schools MolMed and MGC and from other Universities
The Erasmus Postgraduate School Molecular Medicine has two main activities: the
organization of education for postgraduate students, and the stimulation of
cooperation between several departments with regards to translational research.
The aim of this course and workshop is to offer a comprehensive, interactive
introduction to the field of basic and translational Endocrinology, including the
paediatric aspects. The course aims at a small and specialised audience of PhD
students working in this field, who like to gain in-depth knowledge.
This course and workshops are primarily organized for PhD students and postdocs of the
Postgraduate Schools MolMed and MGC. Other participants, such as: students, young
MD’s and research technicians of the Erasmus MC or LUMC, as well as other researchers
in this field are welcome on ‘first come first served’ basis. The total number of
participants is limited to 25, the maximum of participants who give presentations is 16.
In the course program, a more important role is reserved for self-study of the
participants under the guidance of the teachers and moderators, and their presentations
about chosen subjects on Thursday afternoon and the whole Friday.
Days 1 and 2, Monday and Tuesday morning, will start with an overview given by the
moderator in a Q&A form by the participants themselves, as a ‘refreshments class’. The
morning and afternoon sessions of the Monday, Tuesday and Thursday are each
dedicated to one of the 6 specific themes of this course & workshop.
For the first time, we organise a special Mini-symposium with 4 keynote
speakers on Wednesday, in the afternoon session. The central theme will
be: Epigenetics. Internationally renowned keynote speakers will
highlight these themes of the course:
 Frank Grosveld, on Epigenetic regulation of gene expression;
 Marika Charalambous, on Imprinted genes in relation to
"developmental origins of health";
 Arturo Hernandez, on Genomic imprinting of the Dio3 locus; studies in
Dio3-/- mice;
 Lisette Stolk, on Epigenetics & high throughput
The keynote speakers will be announced widely in Erasmus MC.
We expect that the participants study previously some chapters from the
recommended textbook of this course:
Boron en Boulpaep; Medical Physiology, Second Edition
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HOMEWORK BEFORE START OF COURSE (FROM TEXTBOOK Boron en Boulpaep)
A] Introduction
1. Biosynthesis of hormones
2. Storage and secretion
3. Hormones in blood
4. Autocrine/paracrine secretion
5. Hormone degradation
B] Mechanisms of hormone action
1. Hormonal actions mediated by intracellular receptors
2. Hormonal actions mediated by surface receptors
C] Regulation of hormone secretion
1. Positive feedback
2. Negative feedback
3. Feed forward
4. Integration with central nervous system
D] Measurements of Hormones
1. Principles of Radioimmunoassay
2. Day and night rhythms of blood hormone levels
We do not expect that you can reproduce it, but you should know the principles
and the terminology. The chapters are:
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Chapter
Chapter
Chapter
Chapter
Chapter
Chapter
3 Signal transduction pp 48-74
47 Organization of endocrine control pp 1011-1027
49 The thyroid gland pp 1044-1056
50 The adrenal gland pp 1057-1073
51 The endocrine pancreas pp 1074-1093
55 The female reproductive system pp 1146-1169
The last day is dedicated to interactive presentations and discussions of
items as mentioned in the program. This is organised as follows:
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Participants will be divided in pairs by the organization, before the course
starts;
Every pair is assigned two topics, mentioned in the program;
The pairs receive in time in advance some most useful publications for the
assigned topics from the organisers/moderators, which they must read and
digest in advance;
They contact the moderators as mentioned in the program of day 5;
They can ask all questions to the moderators about how to proceed.
Subscription fees: see below.
Please subscribe as soon as possible. The deadline was Wednesday April 3rd,
via the website of MolMed: www.molmed.nl. We will make the schedule for the
presentations and distribute the publications immediately after this date.
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First Day, Monday April 15th. Room: OWR-14
Morning session: Opening & refreshment, thyroid gland
Moderator: Robin Peeters, Erasmus MC
Time
Speaker
Title
09:00-09:30
Registration & coffee
09:30-10:15
Theo Visser & Robin
Refreshment class
Peeters, Erasmus MC
Endocrine control, hormone
synthesis, signal
transduction, G-protein
coupled receptor
Steroid receptors; Regulatory
Response Elements; Ligand
induced transcription regulation; Co-activation/represssion; Transcriptional clock;
Signal transduction;
Anti-hormone action;
3D-modelling/conformational
changes; orphan receptors
10:15-11:00
Axel Themmen,
Erasmus MC
11:00-11:15
11:15-12:00
Coffee break
Robin Peeters & Alies
Thyroid hormone resistance THRA, THRB, ligand bindind
van Mullem, Erasmus
due to mutations in thyroid
domain, thyroid response
MC
hormone receptors
element, tissue-specificity
Edward Visser, Erasmus Local regulation of thyroid
MC, Rotterdam
hormone activity
Lunch break in foyer OWR (Education Centre), 4th floor
12:00-12:45
12:45-13.30
Nuclear hormone receptors
Keywords
First Day, Monday April 15th. Room OWR-14
Afternoon session: Adrenal
Moderator: Leo Hofland, Erasmus MC
Time
Speaker
Title
13:30-14:15
Leo Hofland, Erasmus
G-protein coupled receptors
MC
14:15-15:00
Liesbeth van Rossum,
Adrenal gland hyper- and
Erasmus MC
hypofunction
15:00-15:15
Coffee break
15:15-16:00
Hans Hofland, Erasmus
Local regulation of cortisol
MC
activity
16:00-16:45
Laura Manenschijn,
Cortisol, a hairy business
Erasmus MC
Second Day, Tuesday April 16th. Room Ae-327
Morning session: Reproduction & refreshment
Moderator: Jenny Visser, Erasmus MC
Time
Speaker
Title
09:15-10:00
Jenny Visser, Erasmus
Refreshment class
MC
10:00-10:45
10:45-11:00
11:00-11:45
Lisette Stolk, Erasmus
Genetics of menarche and
MC
menopause
Coffee break
Joop Laven, Erasmus MC Female infertility (incl.
PCOS)
11:45-12:30
Jenny Visser, Erasmus
MC
Role of AMH in ovarian
function
12:30-13:30
Lunch break in Ae-327, 313 and 316
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Keywords
Keywords
Sex differentiation, gonadal
development, hormonal
regulation
PCOS, PCOM, Hyperandrogenism, Oligo-/anovulation,
Menopause, POI, climacteric
Ovary, follicle selection, FSH
sensitivity, TGFβ family
members
Second Day, Tuesday April 16th. Room Ae-327
Afternoon session: Endocrine aspects of Obesity
Moderator: Erica van den Akker with Jenny Visser, Erasmus MC
Time
Speaker
Title
Keywords
13:30-14:15
Aldo Grefhorst, Erasmus Role of brown adipose tissue Brown adipose tissue, White
MC
in obesity
adipose tissue, Brite adipose
tissue, FDG PET scanning,
obesity, insulin sensitivity,
thermoneutrality
14:15-15:00
Carlijn Kamphuis,
Prevention of obesity
MGZ, Erasmus MC
15:00-15:15
Coffee break
15:15-16:00
Erica van den Akker,
Obesity syndromes –
Erasmus MC
Lessons from nature
16:00-16.45
Patric Delhanty,
Erasmus MC
Mieke van Haelst,
Clinical geneticist, UMCU
In vitro studies of a gene
defect leading to obesity
Genetics of obesity
Third Day, Wednesday April 17th
Morning
09.00-12.00
Self-study and preparation of presentations
Third Day, Wednesday April 17th. Room OWR-36
Epigenetics and its role in endocrinology
Afternoon session: Mini-symposium with 4 keynote speakers
Moderator: Theo Visser & Robin Peeters, Erasmus MC
Time
Speaker
Title
12:00-13:00
Lunch in OWR-36
13:00-13:45
Frank Grosveld,
Epigenetic regulation of
Erasmus MC
gene expression
13:45-14:30
Marika Charalambous, Imprinted genes in relation
Centre f. Endocrinology, to "developmental origins of
William Harvey Research health"
Institute, Barts and The
London School of Med. &
Dent., Queen Mary
University of London
14:30-15:00
Coffee break
15:00-15:45
Arturo Hernandez,
Genomic imprinting of the
Dept. of Physiology,
Dio3 locus; studies in Dio3Dartmouth Medical
/- mice
School, Lebanon, New
Hampshire, USA
16:00-16:45
Lisette Stolk, Erasmus Epigenetics & high
MC
throughput
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Keywords
Imprinting, growth, placenta,
nutrient restriction, gestation,
epigenetics, methylation
Thyroid hormone,
development, imprinting,
deiodinase
Genome-wide association,
menopause, menarche
Fourth Day, Thursday April 17th. Room OWR-15
Morning session: Bone
Moderator: Bram van der Eerden
Time
Speaker
Title
9:30-10:15
Bram van der Eerden,
Calcium and phosphate
Erasmus MC
minerals make up bone:
how are they regulated?
10:15-11:00
11:00-11:15
11:15-12:00
12:00-13:00
Keywords
Bone metabolism, calcium,
phosphate, vitamin D,
parathyroid hormone, energy
metabolism
Carola Zillikens, Erasmus The genetic background of
Osteoporosis, fractures,
MC
osteoporosis, a common and heritability, GWAS, exome
complex disease
sequencing, RANKL,
sclerostin, Wnt signalling
Coffee break
Marjolein van Driel,
Bone and cancer, a vicious
Bone metastases, osteoblasts,
Erasmus MC
circle?
prostate tumor cells, cocultures
Lunch break in foyer OWR (Education Centre), 4th floor
Fourth Day, Thursday April 18th. Room OWR-15
Afternoon session: Glucose, Insulin, IGF
Moderator: Joop Jansen
Time
Speaker
Title
13:00-13:45
Anton Scheurink, RUG,
Hypothalamic control of
Groningen
glucose homeostasis
13:45-14:30
Joop Janssen, Erasmus
Gut hormones and control of
MC
insulin action - to be
determined
14:30-14:45
Coffee break
14:45-15:30
Joop Janssen, Erasmus
The delicate interplay beMC
tween GH, IGF-I and Insulin
Keywords
Incretins, GLP-1, diabetes
mellitus
Incretins, glucagon-likepeptide-1, glucose-dependent
insulinotropic peptide, insulin,
glucagon and bariatric surgery
16.00 Thursday April 17th, afternoon: Erasmus MC Lectures on Endocrinology
16:00 Sabine Costagliola: From stem cells to thyroid: make a gland in a box
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Fifth Day, Friday April 19th. Room OWR-6
Morning session: four presentations by couples of course participants, prepared before:
Hormone sensitivity
Moderator: Jenny Visser & Erica van den Akker, Erasmus MC
Time
Speakers (participants who present)
Title Publication
09:30-10:00
Sara Creemers & Jeffrey Hoek
Obesitas: gendiagnostiek of…
10:00-10:30
Thomas Langerak, Joyce Schuilwerve & Geriolda Topi
Prenatal Diagnosis of
Congenital…
10:30-10:45
Coffee break
10:45-11:15
Marta Baroncelli & Anneke van den Beukel
A Nontargeted Proteomic
Study of…
11:15-11:45
Maurits de Rotte & Sabine Staufenbiel
Bioinactive ACTH Causing …
11:45-12:15
Tim Korevaar & Gerard Noppe
Identification of a SIRT1
Mutation…
12:15-13:15
Lunch break in foyer OWR (Education Centre), 4th floor
Fifth Day, Friday April 19th. Room OWR-6
Afternoon session: four presentations by couples of course participants, prepared before:
Endocrine and neuroendocrine tumors
Moderator: Leo Hofland, Erasmus MC
Time
Speakers
Title Publication
13:15-13:45
Manouk van der Steen & Renske Kuppens
A 12-Month Phase 3 Study…
13:45-14:15
Ling Huang & Ilke Ilgaz
DAXX/ATRX, MEN1, and
mTOR Pathway Genes….
14:15-14.45
Anja van Gucht & Vincent Wester
Everolimus for Advanced
Pancreatic…
14.45-…..
Drinks & say goodbye in OWR 6
Attendance fees
The subscription fee of non-commercial participants for the Course is € 700.
Discounts are handled as followed:
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All PhD students get a discount of 50 % and pay € 350.
All participants from the MolMed school get a discount of 100 % and pay €
0.
If these financial requirements pose a problem but you wish to attend the Course and Workshops,
please contact Frank van Vliet, managing director of the Erasmus Postgraduate School Mol Med, at:
f.vanvliet@erasmusmc.nl.
Invoice
Fees can be paid upon an INVOICE. Shortly after your registration you will receive
the INVOICE per mail. Payment per bank can be done on account: 43.47.01.408 /
Erasmus MC, (IBAN code bank: NL86ANBA0434701408; SWIFT code bank:
ABNANL2A), together with the number on your INVOICE.
Late participants can also pay in cash upon signing in for the Course.
Cancellations
The fees are for all the days of the Course. There is no discount for partaking only
in part of the Course. Our cancellation policy is that cancellation is possible up
to one week before the start of the Course. Later cancellation will not be
accepted, but you are allowed to send a substitute.
Commercial participants & sponsors
Companies are invited to inquire for participation and sponsoring.
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