HORMONE ACTION READING LIST
Signalling in Health and Disease 2010
Background: Chapter 3 Basic and Clinical Endocrinology, Greenspan & Strewler.
G proteins and GPCR
Neer et al (1995) G proteins:organizers of transmembrane signals. Cell 80:249-257.
Stojilkovic et al (1994) GnRH receptors: structure and signal transduction. Endocrine Reviews 15:462499.
Marinissen et al (2001) GPCR and signalling networks: emerging paradigms. Trends Pharm Sci 22:368.
Lu et al (2002) Seven transmembrane receptors: crystals clarify. Trends Pharm Sci 23:140.
Bockaert et al (2003) The magic tail of GPCR. FEBS Letts 546:65-72.
Salapour et al (2000) Significance of oligomerization of GPCR. Trends Endocrin Met, 11 (5): 163-170.
The ins and outs of GPCR trafficking. Trends Biochem Sci 28:369.
Yu et al (1998) Hormone resistance in Gs protein  knockout mice. PNAS 95:8715-20.
Offermanns et al (1997) Defective platelet activation in Gq -deficient mice. Nature 389:183-6.
Multiple G protein activation
Laugwitz et al (1996) TSH receptor stimulates members of all four G protein families. PNAS 93: 116-120.
Kleuss et al (1992) Different  subunits determine G-protein interaction. Nature 358:424-425.
Wolfe et al (2003) T-type calcium channel regulation by  subunits. Nature 424:209-213.
Vilardaga et al (2003) Measurement of the activation switch of GPCR. Nature Biotechnology 21:807
Desensitisation
Bohn et al (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2 Science 286:2495-2498.
Pierce et al (2001) New roles of arrestins in regulation of GPCR. Nature Revs Neuroscience 2:727-733.
Spiegel (2003) Arrestin not just for GPCR. Science 301:1338-9.
Crosstalk effects on transcription via second messengers and MAP kinase cascades
Gutkind (1998) Pathways connecting GPCR to the nucleus via MAP kinases. J Biol Chem, 273:1839-1842.
Farfel (1999) The expanding spectrum of G protein diseases. New Engl J Med 340 (13):1012-1020.
Estrada et al (2003) Testosterone stimulates MAP kinases via a GPCR. Endocrinology 144:3586-3597.
Discovery of new peptide hormone receptors
Hinuma et al (1998) A prolactin-releasing peptide in the brain. Nature 393: 272-276.
Wilson (1998) Orphan GPCR: the next generation of drug targets? Br J Pharmacol 125:1387-1392.
Crosstalk effects on transcription via second messengers and MAP kinase cascades
Defea (2000) Effects of substance P are facilitated by beta-arrestin scaffolding. PNAS 97: 11086 11091.
Gutkind (1998) Pathways connecting GPCR to the nucleus via MAP kinases. J Biol Chem, 273:1839-1842.
Farfel (1999) The expanding spectrum of G protein diseases. New Engl J Med 340 (13):1012-1020.
1
Estrada et al (2003) Testosterone stimulates MAP kinases via a GPCR. Endocrinology 144:3586-3597.
Watters et al (2000) Estrogen modulation of PRL via MAP kinase pathway. Mol Endocrinol
14:1872-1881.
Razandi et al (1999) Membrane and nuclear ER originate from 1 transcript. Mol Endocrinol 13:307-319.
McCarthy (2004) Out with the new, in with the old: classical estrogen receptors mediate novel estradiol
actions in the brain. Endocrinology 3053-4.
General Steroid hormone ‘classical action’ Reviews
O'Malley et al (1991) Rec Prog Horm Res 47:1-26 Mechanism of action of a steroid receptor.
Beato et al (1995) Cell 83:851-857 Steroid hormone receptors; many actors in search of a plot.
Mangelsdorf et al (1995) Cell 83:835-839 The nuclear receptor superfamily; the second decade.
Fannon et al (2001). J Appl Physiol 91:1854-59. A history of sex steroid hormone action.
Transfer of intracellular receptors to the nucleus
Guiochon-Mantel et al (1996) J Steroid Biochem Mol Biol 56:3-9 Intracellular traffic of SRs.
Czar et al (1994) Mol Endocrinol 8:1731-1741 HSP56 localization to microtubules and nucleus.
Smith DF et al (1993) Mol Endocrinol 7:4-11 Steroid receptors and associated HSPs.
Stenoien et al (2000) Mol Endocrinology 14:518-534. Subnuclear trafficking of ERα and SRC1.
Htun et al (1996) PNAS 93:4845-50. Visualisation of GR translocation to the nucleus.
McNally et al (2000) Science 287:1262. GR exchange with regulatory sites.
Orphan nuclear receptors and steroid receptor crosstalk
Trapp et al (1996) J Biol Chem 271:9879-9882 Orphan receptor represses GR action.
Power et al (1991) Science 252:1546-1548 DA activation of COUP-TF orphan receptor.
Bamberger (1997) J Steroid Biochem Mol Biol 60:43-50 Inhibition of MR by GR.
Steroid receptor knockouts
Korach et al (1994) Science 266:1524-1526 Effects of knockout of ER alpha .
Zhu et al (2002) Science 295:505-508. Hypertension in mice deficient in ER beta.
Steroid receptor co-regulators
Auboeuf et al (2002) Science 298:416. Coordinate regulation of transcription by SR coregulators.
Onate et al (1995) Science 270:1354. First coactivator, SRC1, characterised.
Shang et al (2002) Science 295:2465.Molecular determinants of SERMs.
McKenna et al (2000) J Steroid Biochem Mol Biol 74:351-6. Diversity in coregulator function.
Yeh et al (1998) PNAS 95:5527-5532. Cloning and characterization of coactivator ARA70.
Spencer (1997) Nature 389:194-198 SRC-1 is a histone acetyltransferase.
Hermanson et al (2002) Trends Endo Metab 13:55-60. Nuclear receptor coregulator modification.
2