Honors Biology
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Honors Biology - Pedigrees 1. Alice and Bob have a two year old son, Charles, who is showing mental retardation, short stature, and cryptorchidism. Alice has two living, unaffected, brothers but her eldest brother died at age 9 and a second brother died aged 10 months. Both had similar problems to Charles. Alice's father, David, who was symptomless, has a sister, Ethel, who has an unaffected boy and girl, and a brother, Fred, who also has two unaffected children. Alice's mother, Gertrude, has two living sisters and had a brother who had died in childhood and who, she remembers, had been mentally retarded. Bob has two brothers, Henry and Ignatius, who are still unmarried. His parents, John and Kate, had tragic lives, both were adopted and never knew their biological parents and both died as the result of a road accident. 2. The Blackett Family DNA Activity is largely a genetic study of the inheritance of alleles in an extended family. Bob Blackett has tested DNA samples from himself and 13 other relatives. The first task of a human geneticist is the creation of a family tree, or pedigree to help with the interpretation of genotypes. From the following relationships, construct a pedigree for the Bob and his relatives. Person Bob Anne David Katie Fred Norma Karen Steve Tiffany Melissa Amanda Louise Bud Buddy Dick Marilyn Janet Family Relationship Our propositus Wife Son Daughter Father Mother Sister Husband of Karen Daughter of Karen and Steve Daughter of Karen and Steve Daughter of Karen and Steve Sister of Fred; Bob's Aunt Husband of Louise Son of Bud and Louise Son of Bud and Louise Daughter of Bud and Louise Daughter of Bud and Louise Honors Biology - Pedigrees 1. Alice and Bob have a two year old son, Charles, who is showing mental retardation, short stature, and cryptorchidism. Alice has two living, unaffected, brothers but her eldest brother died at age 9 and a second brother died aged 10 months. Both had similar problems to Charles. Alice's father, David, who was symptomless, has a sister, Ethel, who has an unaffected boy and girl, and a brother, Fred, who also has two unaffected children. Alice's mother, Gertrude, has two living sisters and had a brother who had died in childhood and who, she remembers, had been mentally retarded. Bob has two brothers, Henry and Ignatius, who are still unmarried. His parents, John and Kate, had tragic lives, both were adopted and never knew their biological parents and both died as the result of a road accident. 2. The Blackett Family DNA Activity is largely a genetic study of the inheritance of alleles in an extended family. Bob Blackett has tested DNA samples from himself and 13 other relatives. The first task of a human geneticist is the creation of a family tree, or pedigree to help with the interpretation of genotypes. From the following relationships, construct a pedigree for the Bob and his relatives. Person Bob Anne David Katie Fred Norma Karen Steve Tiffany Melissa Amanda Louise Bud Buddy Dick Marilyn Janet Family Relationship Our propositus Wife Son Daughter Father Mother Sister Husband of Karen Daughter of Karen and Steve Daughter of Karen and Steve Daughter of Karen and Steve Sister of Fred; Bob's Aunt Husband of Louise Son of Bud and Louise Son of Bud and Louise Daughter of Bud and Louise Daughter of Bud and Louise
