Assistant Research Fellow
Medical Research Center, Cardinal Tien Hospital
Ting-Ting Chao, Ph.D.
Curriculum Vitae (Nov, 2013)
General Information
Name: Ting-Ting Chao, Ph.D. (趙婷婷)
Email: chaotting@gmail.com
Education:
1998 M.S., Department of Life Science and the Institute of Biotechnology, National
Dong Hwa University
2007 Ph.D., Graduate Institute of Life Science, National Defense Medical Center
Postdoctoral Training:
2010/01- 2011/07 Postdoctoral research fellow, National Defense Medical Center,
Tri-Service General Hospital, Neihu, Taiwan.
2008/11-2009/12
Postdoctoral research fellow, Institute of Cellular and System
Medicine, National Health Research Institutes, Zhunan, Taiwan
Hospital Institution Appointments:
2011/08~ present
Assistant Research Fellow. Medical Research Center, Cardinal
Tien Hospital, Taipei
Awards and Honors:
2005
Graduate Institute of Life Science, National Defense Medical Center. Thesis
Research Award Copper Medal, 'Postgraduate Thesis Conference'.
2006
Institute of Biomedical Sciences, Academia Sinica, 'Poster Competition
Award for Attending International Conference'.
2013
天主教耕莘醫院研究獎勵金.
Bibliography
Journal articles:
1.
Wu HC, Huang YL, Chao TT, Jan JT, Huang JL, Chiang HY, King CC, Shaio MF.
Identification of B-cell epitope of dengue virus type 1 and its application in
diagnosis of patients. J Clin Microbiol. 2001, Mar;39(3):977-82. SCI
2.
Wu HC, Jung MY, Chiu CY, Chao TT, Lai SC, Jan JT, Shaio MF. Identification of
a dengue virus type 2 (DEN-2) serotype-specific B-cell epitope and detection of
DEN-2-immunized animal serum samples using an epitope-based peptide
antigen. J Gen Virol. 2003, 84(Pt 10):2771-9. SCI.
3.
Lin, DY, Huang, YS, Jeng, JC, Kuo, HY, Chang, CC, Chao, TT, Ho, CC, Chen,
YC, Lin TP, Fang, HI, Hung, CC, Suen, CS, Hwang, MJ, Chang, KS, Maul, GG,
and Shih, H.-M.*, Role of SUMO-interacting motif in Daxx SUMO modification,
subnuclear localization and repression of sumoylated transcription factors, 2006,
Nov 3; Mol. Cell 24: 341-354. SCI
4.
Chao TT, Chang CC, Shih HM. SUMO modification modulates the
transrepression activity of PLZF. Biochem Biophys Res Commun. 2007, Jun
29;358(2):475-82. SCI
5.
Chen HC, Sytwu HK, Chang JL, Wang HW, Chen HK, Kang BH, Liu DW, Chen
CH, Chao TT, Wang CH. Hypoxia enhances the stemness markers of cochlear
stem/progenitor cells and expands sphere formation through activation of
hypoxia-inducible factor-1alpha. 2010. Dec 10. Hear Res: 1-10. SCI
6.
Wu VC, Huang TM, Wu PC, Wang WJ, Chao CT, Yang SY, Shiao CC, Hu FC, Lai
CF, Lin YF, Han YY, Chen YS, Hsu RB, Young GH, Wang SS, Tsai PR, Chen YM,
✽
✽
Chao TT , Ko WJ , Wu KD; NSARF Group. Preoperative proteinuria is
associated with long-term progression to chronic dialysis and mortality after
coronary artery bypass grafting surgery. PLoS One. 2012. 7(1):e27687.
(Corresponding Author). SCI
7.
Lai CC, Wang CY, Lu HM, Chen L, Teng NC, Yan YH, Wang JY, Chang YT
✽
, Chao TT✽, Lin HI, Chen CR, Yu CJ, Wang JD. Idiopathic pulmonary fibrosis in
Taiwan - A population-based study. Respir Med. 2012. Respir Med. 2012.
106(11):1566-74. (Corresponding Author). SCI
8.
Wang JY#, Chao TT#, Lai CC, Wang CY, Wu VC, Wang SM, Lin HI, Tang SH, Lin
HW. Risk of Colorectal Cancer in Type 2 Diabetic Patients: A Population-based
Cohort Study. Jpn J Clin Oncol. 2013. (Co-first Author). SCI
9.
Chao TT, Wang CH, Chen HC, Shih CP, Sytwu HK, Huang KL, Chen SY.
Adherent culture conditions enrich the side population obtained from the cochlear
modiolus-derived stem/progenitor cells. Int J Pediatr Otorhinolaryngol. 2013 Mar
9. SCI
10. Chao, Ting-Ting; Hsieh, Chang-Hsun; Lin, Jiunn-Diann; Wu, Chung-Ze; Hsu,
Chun-Hsien; Pei, Dee; Chen, Yen-Lin; Liang, Yao-Jen; Chang, Jin-Biou. Use of
white blood cell counts to predict metabolic syndrome in the elderly: a 4 year
longitudinal study. 2013. Aging Male. (revision). SCI.
11. Cheng-Yi Wang,* Ting-Ting Chao,* Wei-Tien Tai, Wen-Pin Su, Yen-Lin Chen,
Pao-Tzu Chen, Ching-Yu Weng, Ang Yuan, Chung-Wai Shiau, Chong-Jen Yu,
and Kuen-Feng Chen. Signal Transducer and Activator of Transcription 3 as
Molecular Therapy for Non-small Cell Lung Cancer. 2013. JTO. (revision). SCI.
12. Hung-Chune Maa*, Ting-Ting Chao*, Cheng-Yi Wang, Dee Pei, Yao-Jen Liang
and Yen-Lin Chen. VEGF-D as a marker in aid of malignant metastatic pleural
effusion diagnosis. 2013. Applied Immunohistochemistry & Molecular Morphology.
(revision). SCI.
Symposium abstracts
1.
Wu, H. C., Huang, Y. L., and Chao T T. Identification of serotype-specific epitope
of dengue virus type I by phage displayed random peptide library. 39th annual
meeting of American Society for Cell Biology. 1999. Washington, D.C. U.S.A.
December 11-15.
2.
Chao TT and Shih HM. PLZF modulates transcriptional activity and subnuclear
compartment of Daxx via sumoylation-dependent manner. Graduate Institute of
Life Science, National Defense Medical Center. Symposium of the 5th Joint
Annual Ph.D. student thesis research Conference. 2005. Taipei, Taiwan.
3.
T.-T. Chao, and H.-M. Shih. SUMO modification modulates the transrepression
potential of PLZF. Regulation of protein function by SUMO modification
Manchester Conference, 25 - 27 June 2007, UK.
4.
T.-T. Chao, and H.-M. Shih. Compartmental regulation of Daxx by Promyelocytic
Leukemia Zinc Finger. Symposium of protein modification by SUMO, Ubiquitin
and Nedd8(SUN). 15-16 Nov 2007. Taipei, Taiwan.
5.
吳佩怡、稅皓靄、莊家欣、趙婷婷、童吉士. Study of Oxidative Stress in PC12 Cells
after Knockdown of Norepinephrine Transporter by RNA Interference Technology.
The Joint Annual Conference of Biomedical Science. 2008. Taipei. Taiwan.
6.
Chen HC, Sytwu HK, Chang JL, Wang HW, Chen HK, Kang BH, Liu DW, Chen
CH, Chao TT, Wang CH. Hypoxia enhances the stemness markers of cochlear
stem/progenitor cells and expands sphere formation through activation of
hypoxia-inducible factor-1alpha. International Symposium of Regenerative
Medicine from Stem Cells to Disease Models. 24-25 Nov 2010. Taipei, Taiwan.
7.
Chao TT and Wang CH. Effective Enhancement of the Side Populations from
Postnatal Mouse Cochlea Stem/Progenitor cells in Adherent Culture System.
2010. 第37屆國軍軍醫學術研討會. 國防醫學院, 台北, 台灣.
8.
陳信傑、司徒惠康、陳杭港、趙婷婷、陳啟煌、康柏皇、王智弘. Identification and
Characterization of Cochlear Stem/Progenitor Cells and the Application of
Hypoxia in Enhancing their Stemness-Marker Expression and Sphere Formation.
2010. 第37屆國軍軍醫學術研討會. 國防醫學院, 台北, 台灣.
9.
鄭皓娟、林怡鈴、江敏彰、陳杭港、陳信傑、趙婷婷、林怡君、王智弘. The Investigation
of Cochlear Inflammatory Process Following Noise Trauma. 2010.第37屆國軍軍
醫學術研討會. 國防醫學院, 台北, 台灣.
10. Chen HC, Sytwu HK, Wang HW, Chen HK, Kang BH, Chen CH, Chao TT, Wang
CH. Hypoxia enhances the expression of stem/progenitor-cell markers and
expands cochlea-derived sphere formation through hypoxia-inducible
factor-1alpha. The 2nd East Asian Symposium on Otology. Nov. 28, 2010. Taipei,
Taiwan.
11. Chen HC, Sytwu HK, Wang HW, Chen HK, Kang BH, Chen CH, Chao TT, Wang
CH. Hypoxia enhances the expression of stem/progenitor-cell marker and
expands formation in cochlea-derived spheres mediated by hypoxia-inducible
factor-1 alpha. 89th Annual Meeting Taiwan Otolaryngological Society. Nov, 2010.
Taipei, Taiwan.
12. Cheng-Yi Wang1,2, Ting-Ting Chao2, Chung-Wai Shiau3, Ang Yuan4, Chong-Jen
Yu5, Pao-Tzu Chen2, Ching-Yu Weng2, Kuen-Feng Chen6, 7. SC-1, a sorafenib
derivative, induces apoptosis in epidermal growth factor receptor wild type
non-small cell lung cancer through the inhibition of signal transducers and
activators of transcription 3. AACR. March31-April4, 2012. Chicago.
13. Cheng-Yi Wang1,2, Ting-Ting Chao1, Wei-Tien Tai3,4, Yen-Lin Chen5, Pao-Tzu
Chen1, Ching-Yu Weng1, Ang Yuan6, Chung-Wai Shiau7, Kuen-Feng Chen3,4 and
Chong-Jen Yu8. Targeting Signal Transducer and Activator of Transcription 3 as
Molecular Therapy for EGFR-wild Type Non-small Cell Lung Cancer. 2012
Annual Meeting of Taiwan Society of Pulmonary and Critical Care Medicine.
December 8-9. 2012. Tainan, Taiwan.
14. Ting-Ting Chao, Ph.D1, Fang-Yu, Chang1,2, Yu-ting Tseng1, Ching-Yu Weng1,
Pao-Tzu Chen1 and Cheng-Yi Wang, MD*1,2 . Molecular Mechanism of the
Synergistic Interaction of Erlotinib with Pemetrexed in Non-Small-Cell Lung
Cancer Cells. The 28th Joint Annual Conference of Biomedical Science. March
23-24, 2013. Taipei. Taiwan.
15. Pao-Tzu Chen1, Cheng-Yi Wang, MD1,2, Fang-Yu, Chang1,2, Ching-Yu Weng1,
Chung-Wai Shiau*, Ph.D3 Kuen-Feng Chen* M.D.,Ph.D4,5 and Ting-Ting Chao*,
Ph.D1. Erlotinib and Its Derivative Modulate Anti-cancer Effect via
EGFR-TKI-Independent Signal in NSCLC Cells. The 28th Joint Annual
Conference of Biomedical Science. March 23-24, 2013. Taipei. Taiwan.
16. Ting-Ting Chao1, Cheng-Yi Wang1,2, Fang-Yu Chang1, Yen-Lin Chen3,
Chung-Wai Shiau4 and Kuen-Feng. CIP2A is a novel therapeutic target for an
erlotinib derivative in EGFR wild-type NSCLC cells. AACR-NCI-EORTC
International Conference. October 19-23, 2013. Boston, MA. USA.
17. Cheng-Yi Wang1,2, Ting-Ting Chao1, Fang-Yu Chang1, Yen-Lin Chen5, Pao-Tzu
Chen1, Ching-Yu Weng1, Chung-Wai Shiau6#, Kuen-Feng Chen3,4# , and
Chong-Jen Yu7# CIP2A is a Target for Erlotinib Derivative in EGFR Wild-type
Non-small Cell Lung Cancer. 2013 Annual Meeting of Taiwan Society of
Pulmonary and Critical Care Medicine. 2013. Taiwan.
Research projects:
1.
Sorafenib衍生物, SC-43, 抑制非小細胞肺癌細胞生長研究―標的分子STAT3
之探討. CTH-101-2-2A01. 耕莘醫院. 101.01~101.12.
2.
以STAT3蛋白為標靶作為上皮細胞生長因子接受體(EGFR)野生型非小細胞肺
癌之分子治療. NSC 101-2314-B-567-001-MY3. 國科會. 101.08~103.07.
3.
蛋白質親合尿毒症與內皮前驅幹細胞之探討—急性腎損傷模式從臨床到基礎.
NSC 101-2314-B-002-132-MY3. 國科會. 101.08~103.07.
4.
表皮生長因子接受器(EGFR)野生型非小細胞肺癌之轉譯研究: 發展新型
CIP2A蛋白抑制劑. CTH-102-1-2A29. 耕莘醫院. 102.01~102.12.
5.
表皮細胞生長因子酪氨酸激酶拮抗劑(EGFR-TKI)及其衍生物之替代分子機轉
研究: 以CIP2A/PP2A/Akt路徑作為肺癌新穎標靶治療應用之分析. NSC
102-2314-B-567-001-MY2. 國科會. 102.08~103.07.