The Curative Effect of Elicina Cream®

The Curative Effect of Elicina Cream®
on Mild-to-Moderate Acne
Jin Young-Jung, Jin Mo-Park, Eun Cheon-Han, Sang Ho-Oh, Ki Yang-Jung
Dermatology Clinic, Yonsei University College of Medicine
1. Etiology: Abnormal keratinization of the hair follicles; increased sebiparous
proliferation of propionibacterium acne, and inflammation
2. Treatment (local): Local antibiotics, retinoid, azelic acid, hormonal agent, etc.
Elicina Cream®
1. Constituents: Snail mucus (80%) containing allantoin (effective for skin
regeneration), glycolic acid (dissolves keratin), collagen and elastin (constituents of
the derm), and a trace amount of some animal amino acids and antibiotic substances
2. Application: After procedures like laser resurfacing, chemical peeling or
microdermabrasion of a scar, acne, burnt areas, wrinkles, and stretch marks
This study was conducted to determine the curative effects of Elicina Cream on mild-tomoderate acne.
1. Study Period: September 1, 2006 – June 30, 2007
2. Subjects: Acne patients aged 15 years and over, with a Cunliffe’s grade of 3.0 or
below (ratio of men to women out of a total of 48 subjects = 21:27; average age: 23)
Exclusion criteria for the subjects:
(1)Pregnancy, breastfeeding, or planned pregnancy within six months
(2)Infectious skin diseases
(3)Took retinoid within three months before the commencement of the study
(4)Took systemic steroids or oral antibiotics within one month before the
commencement of the study
(5)Underwent acne treatment for other local acne
(6)Atopic skin disease
(7)Severe irritation due to cosmetics, medicines, or normal exposure to sunlight, or
allergic response
3. Study Methods
- An eight-week random, double-blind study
- Patient group (n=24): Twice-daily application (morning and evening) of
Elicina Cream for eight weeks
- Control group (n=24): Twice-daily application (morning and evening) of
placebo cream for eight weeks
- The patients visited the hospital before (0 week) and after (at 2, 4, 6, and 8
weeks) the commencement of the treatment, and pictures of them were taken.
Assessments were performed by both the patients and the researchers.
4. Evaluation Indicators
- Objective indicators: Erythema, non-inflammatory lesions (obstructive and
open comedo), inflammatory lesions (papule and pustule)
- Patients’ and physician’s assessment of the cream’s curative effect:
Evaluation of the improvement of their acne (marked improvement, slight
improvement, no change, poor)
1. Change in the number of lesions after the treatment
2. Assessment of the treatment’s curative effect
3. Adverse effects
Patient group: Irritation (3 patients, 2.5%), dryness (2 patients, 8.3%)
Control group: Irritation (2 patients, 8.3%), dryness (2 patients, 8.3%)
The overall lesions, erythema, inflammatory lesions, and non-inflammatory lesions
were reduced two to four weeks earlier in the patient group than in the control
group after the treatment.
A random, double-blind study was carried out. The results before and after the
treatments could not be compared because differences were observed in the overall
lesions, erythema, and inflammatory lesions.
It is suggested that Elicina Cream is effective in rapidly improving acne lesions.