STANFORD CAREER DEVELOPMENT PROGRAM IN THE ‘OMICS’ OF LUNG DISEASES APPLICATION FORM Complete Sections A-D, and the list in Section E with the names of the three people you have asked to write letters of recommendation and the dates you asked them. We will notify you when all required materials have been received. Submit application and supporting materials as a single PDF file (preferred) or in hard copy to: Michelle Fox Program Administrator Career Development Program in the “Omics” of Lung Diseases Stanford University School of Medicine CCSR-Room 1215A 269 Campus Drive, Stanford, California, 94305-5162 mfox1@stanford.edu Section A. Applicant information Name of applicant: Last name (family or surname) First Middle Address for correspondence: E-mail address: Telephone: (Work) Birth Place: (Home) Date: (Cell) Citizenship: Stanford University affirms strongly its practices, policies, and purposes for affirmative action: Ethnic self description: American Indian Asian/Pacific Islander Hispanic African-American Caucasian Background (check all that apply): Individuals from racial and ethnic groups that have been shown by the National Science Foundation to be underrepresented in health-related sciences on a national basis. Individuals with disabilities, who are defined as those with a physical or mental impairment that substantially limits one or more major life activities. Individuals from disadvantaged backgrounds who are defined as either individuals who come from a family with an annual income below established low-income thresholds or individuals who come from a social, cultural, or educational environment such as that found in certain rural or inner-city environments that have demonstrably and recently directly inhibited the individual from obtaining the knowledge, skills, and abilities necessary to develop and participate in a research career. Section B. Curriculum Vitae (CV) NIH Biographical Sketch (sample/format: http://grants.nih.gov/grants/funding/phs398/phs398.html) or similar. Please include: All your publications (titles, all authors, complete references) Current position and source of funding Previous research experience Revised 2/15/16 STANFORD CAREER DEVELOPMENT PROGRAM IN THE ‘OMICS’ OF LUNG DISEASES Section C. Proposed Research Project, Mentor and Co-Mentors (1 page) Submit a summary of your proposed research project, the proposed mentor and two co-mentors. All three disciplines should be represented by the mentor/co-mentors: Pulmonary Hypertension, Omics, and Bioinformatics. (see last page for a summary of the program and the list of mentors and comentors). Section D. Career Development Plan (1/2 page) Briefly describe your career goals and how this program in ‘omics’ and pulmonary hypertension would contribute to your overall career development. Also include: Special areas of research skills and knowledge base you wish to strengthen If you have made any commitments that would preclude a 2-3 year commitment to this program Section E. Letters of Recommendation (two) Applicant must arrange for two letters of recommendation to be sent, one can come from the Mentor and the other from another research mentor, training director, or clinical supervisor. Provide below the name, position, address, phone number, and email for the individuals. It is the applicant or mentor’s responsibility to ensure that these letters of recommendation are submitted. The instruction form is on the next page. Letters of Recommendation Date Requested (list name, position, address, phone number, and e-mail address) 1 2. Certification I certify that the information provided in this application is true, complete, and accurate to the best of my knowledge. Applicant Signature Revised 2/15/16 Date STANFORD CAREER DEVELOPMENT PROGRAM IN THE ‘OMICS’ OF LUNG DISEASES RECOMMENDATION FORM is applying for a Scholar position in the Stanford (Name of applicant) Career Development Program in the ‘Omics’ of Lung Diseases. We would appreciate your evaluation of the applicant's accomplishments, including research/clinical skills and judgment, intellectual independence, capacity for analytical and creative thinking, ability to organize and express ideas clearly, potential for teaching, and his/her motivation for entering this program. We are particularly interested in identifying individuals with potential for leadership in this field. Please indicate how long you have known the applicant and in what capacity. Thank you for your assistance in our evaluation of this applicant. Your letter, in electronic (PDF) form (preferred) or in hard copy, should be sent directly to: Michelle Fox Program Administrator Career Development Program in the “Omics” of Lung Diseases Stanford University School of Medicine CCSR-Room 1215A 269 Campus Drive, Stanford, California, 94305-5162 mfox1@stanford.edu Revised 2/15/16 STANFORD CAREER DEVELOPMENT PROGRAM IN THE ‘OMICS’ OF LUNG DISEASES NIH/NHLBI Funded Stanford Career Development Program in ‘Omics’ of Lung Diseases (K12) We propose a Career Development Program (CDP) in ‘Omics’ of lung diseases with a major focus on pulmonary arterial hypertension (PAH). This is a logical extension of our current K12 CDP on the “Genetics and Genomics of Lung Diseases” that focuses on PAH. The new CDP proposal allows us to equip the next cadre of MD and PhD scientists with interdisciplinary and bioinformatic skills to integrate new high throughput genomic, proteomic and metabolomic platforms to gain a better understanding of disease pathophysiology. This proposed CDP in ‘Omics’ will fuel the major cross–departmental collaborations we have built through NIH-NHLBI Interdisciplinary grants focusing on PAH. One of our NIH sponsored projects applies novel cutting-edge high-throughput proteomic methodologies to investigate inflammatory cells in autoimmune and idiopathic PAH. Another utilizes genomics and bioinformatics and induced pluripotent stem cell methodology to relate gene variants, methylation changes and RNA expression differences across the genome, to the functional behavior of native and iPSCderived endothelial cells from PAH patients. Our role in the Pulmonary Hypertension Breakthrough Initiative Network permits access to these valuable samples, and our major clinical programs in Adult and Pediatric PAH assures that we are well-positioned to train a new generation of young scientists in this important area of research. Our Scholars will have MD or PhD backgrounds and our CDP offers extensive didactic cross training in the ‘omics’ (genomics, proteomics, metabolomics) and in computational biology, particularly for the MD with little background preparation in these areas. As well, for the PhD Scholar we offer training in lung vascular anatomy, physiology and pathology for the PhD Scholar with little exposure to medicine. Each Scholar will undertake a mentored research project beginning in the first year of training, with a primary Mentor who has expertise in PAH, in the ‘Omics’ fields, or in Bioinformatics, and two Co-Mentors with the complementary skills. Mentors and CoMentors will help the Scholar attain those skills that facilitate interpreting the large data sets resulting from high throughput research with large data sets to uncover the biological and clinical relevance of the findings. Our CDP focuses on one disease but, at the same time, provides the Scholar with the necessary tools to take on the challenges of future high throughput scientific discovery, to improve diagnosis and treatment in of many other lung diseases. Mentors - Pulmonary Arterial Hypertension (PAH): Marlene Rabinovitch Mark Nicolls David Cornfield Mentors - Omics: Mike Snyder Maria Barna Pat Brown Gil Chu Mark Krasnow Andy Fire Stephen Quake Garry Nolan James Chen PJ Utz Bill Robinson Pehr Harbury Mentors- Bioinformatics: Russ Altman Carlos Bustamante Atul Butte Gil Bejerano Additional clinical / junior Faculty who can serve as co-Mentors: Edda Spiekerkoetter (PAH) Vinicio de Jesus Perez (PAH) Roham Zamanian (PAH) Jeff Feinstein (PAH) Purvesh Khatri (Bioinformatics) Stephen Montgomery (Bioinformatics) Revised 2/15/16