Program Director/Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
David Barba
eRA COMMONS USER NAME (credential, e.g., agency login)
DBARBA
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
University of Southern California
B. S.
09/75
Biology
University of Southern California
M. D.
09/79
Medicine
University of Southern California
University of California San Diego
Internship
Residency
06/80
06/85
Surgery
Neurosurgery
NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions
below.
A. Personal Statement
The goal of the proposed research is to develop a clinical research model system to explore techniques with
the potential for a 10x improvement in spatial scale while allowing patients to be anesthetized. Specifically we
will measure the neuronal activity in anesthetized patients undergoing surgical resection of brain lesion, such
as temporal lobectomy, for epilepsy refractory to medical therapy. I have extensive experience in the functional
neurosurgery over 10 years at UCSD. I am an active number of both our epilepsy and movement disorder
teams. These are multi-modality teams that have joint clinics and team meetings to evaluate patient's and
treatments. I see more than 50 clinic patient's a month and we surgically treat approximately 25 patients a year
in the functional neurosurgery program associated with the epilepsy program. I have a broad background in
clinical trials. I ran a trial in the immunologic therapy for brain tumors as a research fellow at the National
Institute of Health. I completed a phase I trial of nerve growth factor gene therapy for Alzheimer's disease and
served as a co investigator in a multi-center phase II trial of the same study. I am currently collaborating with
Prof. Eric Halgren in an IRB approved study of neuronal activity associated with language in awake patients
undergoing temporal lobectomy for epilepsy. The proposed studies in epilepsy patients will be done in
collaboration with Prof Halgren. We anticipate in the future that the development of this research model has the
potential to refine mapping techniques used for tissue resection surgery and to accelerate human
neuroscience research.
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page
Program Director/Principal Investigator (Last, First, Middle):
B. Positions and Honors
Shinshu University
Research fellow
06/84
University of Western Ontario
EC-IC Bypass fellow 02/86
stroke treatment
National Institute of Health, NINCSD
Research fellow
10/88
neuroimmunology. gene therapy
University of California San Diego
Assistant Professor
07/89
neurosurgery
University of California San Diego
Associate Professor 06/95
neurosurgery
University of California San Diego
Professor, Clinical
neurosurgery
06/03
microvascular neurosurgery
“In Vivo Gene Transfer Using Implanted Retroviral Producer Cells”
US Patent No. 6,663,858
“In Vivo Gene Transfer Using Implanted Retroviral Producer Cells”
US Patent No. 6,663,857
C. Selected Peer-reviewed Publications
McDonald, Carrie; Donald J Hagler, Jr.; Girard, Holly;Pung, Christopher; Ahmadi, Mazyar; Dominic
Holland; Rajan H Patel; Barba, David; Tecoma, Evelyn; Iragui-Madoz, Vicente; Halgren, Eric; Anders
M Dale. Post-operative changes in fiber tract integrity and visual fields after anterior temporal
lobectomy Neurology, 2010 Nov2;75(18):1631-8
Schettino, L., Van Erp, E., Hening, W., Lessig, S., Song, D., Barba, D., And Poizner, H.: Deep Brain
Stimulation of the subthalamic nucleus Facilitates coordination of hand preshaping in Parkinsons Disease.
International Journal of Neuroscience, 2009, 119, 1905-1924
Barba D, Hardin J, Sadelain M, Gage FH: Development of anti-tumorimmunity following thymidine
kinase-mediated killing of experimental brain tumors. Proc NatI Acad Sci 91:4348-4352, 1994.
D. Research Support
5% Salary support for effort for with Alzheimer’s Disease Research Center , UCSD for NGF gene therapy for
Alzheimer’s Disease, NIH, Ceregene.
4% Salary support for effort with Grant #: 006454-002 ONR Bazhenov (PI) Project Period: 7/1/20136/30/2018, Memory Consolidation During Sleep in Humans, Rodents and Computational Models
PHS 398/2590 (Rev. 06/09)
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Continuation Format Page