Dr Sibel Zehra Aydın
Associate Professor, MD
Address:
Koc University,
Mob:
+ 90 505 357 7486
Faculty of Medicine
Istanbul Turkey
Nationality: Turkish
Email: drsibelaydin@gmail.com
EDUCATION AND QUALIFICATIONS
-Associate Prof in Rheumatology, 2012
Rheumatologist, Marmara University Medical School Hospital, Istanbul, 2009
- Internist, Marmara University Medical School Hospital, Istanbul, 2005
- MD, Istanbul University, Istanbul Faculty of Medicine, 2000
FELLOWSHIPS
Nov 2009 –Feb 2011 Research Fellowship
University of Leeds, Leeds, UK
Aug 2005 – Nov 2009 Rheumatology Fellowship
Marmara University Faculty of Medicine, Istanbul, Turkey
Nov 2000- Dec 2004
Internal medicine Fellowship
Marmara University Faculty of Medicine, Istanbul, Turkey
PAST/ PRESENT POSITIONS
Dr S.Z. Aydin – Curriculum Vitae
1
March 2014- present: Associated Professor, Senior lecturer in Rheumatology
Koc University, Faculty of Medicine, Rheumatology department
March 2011- March 2014: Associated Professor, Senior lecturer in Rheumatology
Istanbul Medeniyet University, Rheumatology department
PUBLICATIONS
Author in 57 publications in peer reviewed journals. First author in 14 and last author in
4 articles, most of which are published in high-ranking rheumatology journals. The list
of publications and impact factor of the journals are given below. First publication in the
field of rheumatology was in 2008; with 371 citations and an H index of 13 so far.
GRANTS and MEMBERSHIPS
2008-2009
Grant by ARTICULUM fellowship
2009
Grant by Turkish Education Foundation (TEV)
2009
Grant by Turkish Society of Research and Training in Rheumatology
2008
Membership of Turkish Medical Association (TMA)
2008
Membership of Turkish rheumatology association
Member of the OMERACT US group
Member of the OMERACT vasculitis group
2010
Targeted Ultrasound Initiative- as a part of UK TUI
2012
EMEUNET
2012
GRAPPA
2013
Targeted Ultrasound Initiative- as the formal ambassador of TUI- Turkey
Dr S.Z. Aydin – Curriculum Vitae
2
INTERNATIONAL MEETINGS PARTICIPATING AS A
CHAIRPERSON OR A SPEAKER
2014
EULAR (European League of Rheumatism), Paris, France
2013
ACR (American College of Rheumatology), San Diego, USA
2013
Arthritis workshop, Leuven, Belgium
2013
EULAR (European League of Rheumatism), Madrid, Spain
2013
Belgian Society of Rheumatology, Brussels, Belgium
2013
INFORM meeting, Vienna, Austria,
2011
Musculoskeletal US course, EULAR, Leeds, UK
2010
Musculoskeletal US course, Sao Paolo, Brasil
2010
US of the hand in rheumatologic disorders , Bologna, Italy
CURRENT INTERNATIONAL RESEARCH ACTIVITIES
International Delphi on disease activity assessment tools – Principal investigator of an
international Delphi exercise; OMERACT Large vessel vasculitis subtask force
Accurate radiographic assessment methods in Ankylosing Spondylitis- principal
investigator in collaboration with UK and Canada
Biomarkers in patients with remission in rheumatoid arthritis - Comparison with
Ultrasound- principal investigator in collaboration with UK and USA- Crescendo.
Targeted Ultrasound Initiative (TUI) in rheumatoid arthritis- TUI ambassador of Turkey
Definitions of ultrasound findings in dactylitis- co-investigator in OMERACT
ultrasound dactylitis subtask force
Dr S.Z. Aydin – Curriculum Vitae
3
BACKGROUND FOR MUSCULOSKELETAL
ULTRASONOGRAPHY
Training: Started musculoskeletal ultrasonography (MSUS) in 2006.
Attended more than 10 courses on MSUS including basic, intermediate and
advanced levels.
Fellowship on MSUS, Ancona, Italy, 2007.
Research: MSUS is my main research area since 2007.
Most recent related articles:

Ultrasonographic assessment of nail in psoriatic disease shows a link between
onychopathy and distal interphalangeal joint extensor tendon enthesopathy.
Dermatology 2013

The link between enthesitis and arthritis in psoriatic arthritis: a switch to a
vascular phenotype at insertions may play a role in arthritis development. Ann
Rheum Dis. 2013

Psoriasis patients with nail disease have a greater magnitude of underlying
systemic subclinical enthesopathy than those with normal nails. Ann Rheum Dis.
2012
Trainer in MSUS:
MSUS trainer in national courses since 2006
MSUS trainer in international courses since 2009
Courses focusing on hand and feet US for rheumatologists
Brazil - 2010
Istanbul – 2009
EULAR US course – 2011 and 2014
Course on vascular imaging for giant cell arteritis
Oxford - 2010
Participation to US Advisory Boards for Industry-supported Events.
Dr S.Z. Aydin – Curriculum Vitae
4
Membership: Has been a member of the OMERACT US task force since 2008
A member of OMERACT US osteoarthritis subgroup
A member of OMERACT US enthesitis subgroup
A member of OMERACT US tenosynovitis subgroup
A member of OMERACT US dactylitis subgroup
Most recent related articles:

Defining enthesitis in spondyloarthritis by ultrasound: Results of a Delphi
process and of a reliability reading exercise. Arthritis Care Res (Hoboken). 2013

Ultrasound definition of tendon damage in patients with rheumatoid arthritis.
Results of an OMERACT consensus-based ultrasound score focussing on the
diagnostic reliability. Ann Rheum Dis. 2013

A systematic literature review of US definitions, scoring systems and validity
according to the OMERACT filter for tendon lesion in RA and other
inflammatory joint diseases. Rheumatology (Oxford). 2012

Ultrasound in the evaluation of enthesitis: status and perspectives. Arthritis Res
Ther. 2011

The OMERACT ultrasound task force--status and perspectives. J Rheumatol.
2011

A systematic literature review analysis of ultrasound joint count and scoring
systems to assess synovitis in rheumatoid arthritis according to the OMERACT
filter. J Rheumatol. 2011
Audit: Worked in University of Leeds in US clinics and in several projects between Nov
2009-March 2011, under supervision of Paul Emery and Richard Wakefield. During that
time, I was the main investigator of the audit named ‘Targeted ultrasound initiative in
rheumatoid arthritis’, aiming to understand the discrepancies between clinical and
imaging remission in rheumatoid arthritis. The audit included 10 countries and I was
involved in writing the protocol, data collection and analysing the data. The data is
presented in ACR 2011.
Dr S.Z. Aydin – Curriculum Vitae
5
LIST OF PUBLICATIONS
1. Orbai AM1, Weitz J2, Siegel EL2, Siebert S2, Savage LJ2, Aydin SZ2, Luime JJ2,
Elkayam O2, Neerinckx B2, Urbancek S2, de Vlam K2, Ritchlin CT2; GRAPPA
Enthesitis Working Group. Systematic review of treatment effectiveness and
outcome measures for enthesitis in psoriatic arthritis. J Rheumatol. 2014
Nov;41(11):2290-4.
2. Hatemi G, Merkel PA, Hamuryudan V, Boers M, Direskeneli H, Aydin SZ, Yazici
H. Outcome Measures Used in Clinical Trials for Behcet Syndrome: A Systematic
Review. J Rheumatol. 2014 Feb 1. [Epub ahead of print] PubMed PMID: 24488418.
3. Deniz R, Ozen G, Yilmaz-Oner S, Aydin SZ, Erzik C, Gunduz OH, Inanc N,
Direskeneli H, Atagunduz P. Ankylosing spondylitis and a diagnostic dilemma:
coccydynia. Clin Exp Rheumatol. 2014 Jan 24. [Epub ahead of print] PubMed PMID:
24480355.
4. Merkel PA, Aydin SZ, Boers M, Cornell C, Direskeneli H, Gebhart D, Hatemi G,
Luqmani R, Matteson EL, Milman N, Robson J, Seo P, Tomasson G. Current Status of
Outcome Measure Development in Vasculitis. J Rheumatol. 2014 Jan 15. [Epub ahead
of print] PubMed PMID: 24429177.
5. Bakewell CJ, Olivieri I, Aydin SZ et al, OMERACT Ultrasound Task Force.
Ultrasound and magnetic resonance imaging in the evaluation of psoriatic dactylitis:
status and perspectives. J Rheumatol. 2013 Dec;40(12):1951-7.
6. Iagnocco et al OMERACT Ultrasound Task Force. Responsiveness in Rheumatoid
Arthritis. A Report from the OMERACT 11 Ultrasound Workshop. J Rheumatol. 2013
Nov 15. [Epub ahead of print]
7. Terslev L, Naredo E, Iagnocco A, Balint PV, Wakefield RJ, Aegerter P, Aydin SZ et
al on behalf of the OMERACT US Task Force. Defining enthesitis in spondyloarthritis
by ultrasound: Results of a Delphi process and of a reliability reading exercise. Arthritis
Care Res (Hoboken). 2013 Oct 21.
8. Bruyn GA, et al on behalf of the OMERACT Ultrasound Task Force. Ultrasound
Dr S.Z. Aydin – Curriculum Vitae
6
definition of tendon damage in patients with rheumatoid arthritis. Results of an
OMERACT consensus-based ultrasound score focussing on the diagnostic reliability.
Ann Rheum Dis. 2013 Aug 22.
9. Naredo E et al on behalf of the OMERACT Ultrasound Task Force*. Reliability of a
consensus-based ultrasound score for tenosynovitis in rheumatoid arthritis. Ann Rheum
Dis. 2013 Aug;72(8):1328-34.
10. Castillo-Gallego C, Aydin SZ et al. MRI assessment of Axial Psoriatic Arthritis:
extent of disease relates to HLA-B27. Arthritis and Rheumatism 2013, epub ahead of
print.
11. Karadag O, Aydin SZ. Comment on: The value of colour Doppler sonography of the
knee joint: a useful tool to discriminate inflammatory from non-inflammatory disease?
Rheumatology 2013, in press.
12. Güher Saruhan-Direskeneli G, Hughes T, Aksu K, Keser G, Coit P, Aydin SZ et al.
Identification of multiple genetic susceptibility loci in Takayasu’s arteritis. American
Journal of Human Genetics 2013, in press.
13. Merkel P, Direskeneli, H, Aydin SZ, Disease assessment in Takayasu’s arteritis:
How useful is ITAS2010 for the researcher and the clinician? Rheumatology 2013, in
press.
14. Aydin SZ, Tan AL, Hodsgon R et al. Comparison of Ultrasonography and Magnetic
Resonance Imaging for the Assesment of Clinically defined Knee Enthesitis in
Spondyloarthritis. Clin Exp Rheum 2013, in press.
15. Aydin SZ, Castillo-Gallego C, Ash ZR et al. Potential use of Optical Coherence
Tomography and High Frequency Ultrasound for the Assessment of Nail Disease in
Psoriasis and Psoriatic Arthritis. Dermatology, 2013. In press
16. Abignano G, Aydin SZ, Castillo-Gallego C et al. Virtual skin biopsy by optical
coherence tomography: the first quantitative imaging biomarker for scleroderma. Ann
Rheum Dis. 2013 Feb 20.
17. Yegin E, Can M, Yilmaz N, Aydin SZ et al. Activity and damage in granulomatosis
with polyangiitis. Int J Rheum Dis. 2013 Feb;16(1):61-71.
18. Alibaz-Oner F, Aydin SZ, Direskeneli H. Advances in the diagnosis, assessment and
outcome of Takayasu’s arteritis. Clin Rheumatol. 2012; 15(6):526-30.
19. Can M, Aydın SZ, Niğdelioğlu A, et al. Conventional DMARD therapy
(methotrexate-sulphasalazine) may decrease the requirement of biologics in routine
Dr S.Z. Aydin – Curriculum Vitae
7
practice of ankylosing spondylitis patients: A real-life experience. Int J Rheum Dis.
2012 Dec;15(6):526-30.
20. Aydin SZ, Castillo-Gallego C, Ash ZR et al. Ultrasonographic assessment of nail in
psoriatic disease shows a link between onychopathy and distal interphalangeal joint
extensor tendon enthesopathy. Dermatology, 2012; 225(3):231-5.
21. Aydin SZ, Ash ZR, Tinazzi I, et al The link between enthesitis and arthritis in
psoriatic arthritis: a switch to a vascular phenotype at insertions may play a role in
arthritis development. Ann Rheum Dis. 2013 Jun;72(6):992-5.
22. McGonagle D, Aydin SZ, Tan AL. The Synovio-entheseal complex and its role in
tendon and capsular associated inflammation. J Rheumatol Suppl. 2012 Jul;89:11-4.
23. Matteson EL, Maradit-Kremers H, Cimmino MA, et al Patient-reported outcomes in
polymyalgia rheumatica. J Rheumatol. 2012 Apr;39(4):795-803.
24. Dasgupta B, Cimmino MA, Kremers HM, et al 2012 Provisional classification
criteria
for
polymyalgia
rheumatica:
a
European
League
Against
Rheumatism/American College of Rheumatology collaborative initiative. Arthritis
Rheum. 2012 Apr;64(4):943-54.
25. Dasgupta B, Cimmino MA, Kremers HM, et al 2012 Provisional classification
criteria
for
polymyalgia
rheumatica:
a
European
League
Against
Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum
Dis. 2012 Apr;71(4):484-92.
26. Alcalde M, D'Agostino MA, Bruyn GA, et al; OMERACT Ultrasound Task Force. A
systematic literature review of US definitions, scoring systems and validity according
to the OMERACT filter for tendon lesion in RA and other inflammatory joint diseases.
Rheumatology (Oxford). 2012 Jul;51(7):1246-60.
27. Sahin Z, Bicakcigil M, Aksu K, et al, Turkish Takayasu Study Group. Takayasu's
arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey. Arthritis
Res Ther. 2012 Feb 6;14(1):R27.
28. Direskeneli H, Tuna-Erdogan E, Gunduz F, et al PDCD1 polymorphisms are not
associated with Takayasu's arteritis in Turkey. Clin Exp Rheumatol. 2012 Jan-Feb;30(1
Suppl 70):S11-4.
29. Ash ZR, Tinazzi I, Gallego CC, et al Psoriasis patients with nail disease have a
Dr S.Z. Aydin – Curriculum Vitae
8
greater magnitude of underlying systemic subclinical enthesopathy than those with
normal nails. Ann Rheum Dis. 2012 Apr;71(4):553-6.
30. Gandjbakhch F, Terslev L, Joshua F, et al; OMERACT Ultrasound Task Force.
Ultrasound in the evaluation of enthesitis: status and perspectives. Arthritis Res Ther.
2011;13(6):R188
31. Aydin SZ, Maksymowych WP, Bennett AN, McGonagle D, Emery P, Marzo-Ortega
H. Validation of the ASAS criteria and definition of a positive MRI of the sacroiliac
joint in an inception cohort of axial spondyloarthritis followed up for 8 years. Ann
Rheum Dis. 2012 Jan;71(1):56-60
32. Naredo E, Wakefield RJ, Iagnocco A, et al. The OMERACT ultrasound task force-status and perspectives. J Rheumatol. 2011 Sep;38(9):2063-7.
33. Mandl P, Naredo E, Wakefield RJ, Conaghan PG, D'Agostino MA; OMERACT
Ultrasound Task Force. A systematic literature review analysis of ultrasound joint
count and scoring systems to assess synovitis in rheumatoid arthritis according to the
OMERACT filter. J Rheumatol. 2011 Sep;38(9):2055-62. Review.
34. Direskeneli H, Aydin SZ, Merkel PA. Assessment of disease activity and
progression in Takayasu's arteritis. Clin Exp Rheumatol. 2011 Jan-Feb;29(1 Suppl
64):S86-91.
35. Aydin SZ, Ash Z, Del Galdo F, Marzo-Ortega H, Wakefield RJ, Emery P,
McGonagle D. Optical coherence tomography: a new tool to assess nail disease in
psoriasis? Dermatology. 2011;222(4):311-3.
36. Castillo-Gallego C, Aydin SZ, Marzo-Ortega H. Clinical utility of the new ASAS
criteria for spondyloarthritis and the disease activity score. Curr Rheumatol Rep. 2011
Oct;13(5):395-401.
37. Merkel PA, Aydin SZ, Boers M, et al. The OMERACT core set of outcome
measures for use in clinical trials of ANCA-associated vasculitis. J Rheumatol.
2011;38(7):1480-6.
38. Direskeneli H, Aydin SZ, Kermani TA, et al. Development of outcome measures for
large-vessel vasculitis for use in clinical trials: opportunities, challenges, and research
agenda. J Rheumatol. 2011 Jul;38(7):1471-9.
39. McGonagle D, Ash Z, Dickie L, McDermott M, Aydin SZ. The early phase of
Dr S.Z. Aydin – Curriculum Vitae
9
psoriatic arthritis. Ann Rheum Dis, 2011 Mar;70 Suppl 1:i71-6. Review.
40. Yilmaz N, Zehra Aydin S, Inanc N, Karakurt S, Direskeneli H, Yavuz S.
Comparison of Quantiferon-TB Gold test and tuberculin skin test for the identification
of latent Mycobacterium tuberculosis infection in lupus patients. Lupus. 2012
Apr;21(5):491-5.
41. Yazici D, Tokay S, Aydin SZ et al. Anti-Saccaromyces Cerevisiae Antibodies
(ASCA) Are Elevated in Autoimmune Thyroid Disease.
Endocrine. 2010
Oct;38(2):194-8.
42. Aydin SZ, Can M, Atagunduz P, et al. Active disease requiring TNFalpha-antagonist
therapy can be well discriminated with different ASDAS sets: a prospective, follow-up
of disease activity assessment in ankylosing spondylitis. Clin Exp Rheumatol. 2010
Sep-Oct;28(5):752-5.
43. Atagunduz P, Aydin SZ, Bahadir C, et al. Determinants of Early Radiographic
Progression in Ankylosing Spondylitis. J Rheumatol. 2010 Nov;37(11):2356-61.
44. Aydin SZ, Bas E, Basci O, et al. Validation of ultrasound imaging for Achilles
entheseal fibrocartilage in bovines and description of changes in humans with
spondyloarthritis. Ann Rheum Dis. 2010 Dec;69(12):2165-8.
45. Aydin SZ, Yilmaz N, Akar S, et al. Assessment of disease activity and progression
in Takayasu's arteritis with Disease Extent Index-Takayasu. Rheumatology (Oxford).
2010 Oct;49:1889-93.
46. Karadag O, Aksu K, Sahin A, et al. Assessment of latent tuberculosis infection in
Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test. Rheumatol
Int. 2010 Sep;30:1483-7.
47. Bicakcigil M, Aksu K, Kamali S, et al. Takayasu's arteritis in Turkey - clinical and
angiographic features of 248 patients. Clin Exp Rheumatol. 2009 Jan-Feb;27:S59-64.
48. Aydin SZ, Karadag O, Filippucci E, et al. Monitoring Achilles enthesitis in
ankylosing spondylitis during TNF-alpha antagonist therapy: an ultrasound study.
Rheumatology (Oxford). 2010 Mar;49:578-82.
49. Inanc N, Aydin SZ, Karakurt S, et al. Agreement between Quantiferon-TB gold test
and tuberculin skin test in the identification of latent tuberculosis infection in patients
Dr S.Z. Aydin – Curriculum Vitae
10
with rheumatoid arthritis and ankylosing spondylitis. J Rheumatol. 2009 Dec;36:267581.
50. Mumcu G, Inanc N, Aydin SZ, et al. Association of salivary S. mutans colonisation
and mannose-binding lectin deficiency with gender in Behcet's disease. Clin Exp
Rheumatol. 2009 Mar-Apr;27:S32-6.
51. Aydin SZ, Atagunduz P, Erer B, et al. Mannose binding lectin levels are not related
to radiographic damage in ankylosing spondylitis. Rheumatol Int. 2010 Jan;30:415-7.
52. Filippucci E, Aydin SZ, Karadag O, et al. Reliability of high-resolution
ultrasonography in the assessment of Achilles tendon enthesopathy in seronegative
spondyloarthropathies. Ann Rheum Dis. 2009 Dec;68:1850-5.
53. Aydin S, et al. A rare case of sponteneous, bilateral Achilles tendon rupture in
systemic lupus erythematosus and a review of the literature. Lupus 2008 17:1051-2
54. Aydin SZ, Atagunduz P, Temel M, et al. Anti-Saccharomyces cerevisiae antibodies
(ASCA) in spondyloarthropathies: a reassessment. Rheumatology (Oxford). 2008
Feb;47:142-4.
55. Aydin SZ, Atagunduz P, Inanc N, et al. Mannose binding lectin levels in
spondyloarthropathies. J Rheumatol. 2007 Oct;34:2075-7.
56. Yazici D, Tokay S, Aydin S, et al. Echocardiographic evaluation of cardiac diastolic
function in patients with rheumatoid arthritis: 5 years of follow-up. Clin Rheumatol.
2008 May;27:647-50.
57. Yumuk PF, Aydin SZ, Dane F, et al. The absence of early diarrhea with atropine
premedication during irinotecan therapy in metastatic colorectal patients. Int J
Colorectal Dis. 2004 Nov;19:609-10.
Dr S.Z. Aydin – Curriculum Vitae
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