Angela Babbo, M.D Business Address 251 E. Huron, Galter LC-178 Chicago, IL 60611 Contact Information angelababbo@gmail.com EDUCATION Northwestern Memorial Hospital, Chicago, IL 2006-2010 Radiation Oncology Residency, Chief Resident; PGY5. Anticipated graduation: June 2010. Technical experience: 3D-CRT, IMRT; Picker VoxelQ, ADAC, Gamma Knife. Brachytherapy: Prostate LDR, Gyne HDR and LDR, Mammosite, Lung mesh and Sarcoma brachytherapy, Therasphere. One month brachytherapy externship to be done at Brigham and Womens’ Hospital, Boston, MA (February 2010) Northwestern University, Feinberg School of Medicine, Department of Radiology, Chicago, IL 2005-2006 Post-doctoral fellowship. Translational research in Radiation Oncology and Nanotechnology. Michael Reese Hospital, Chicago, IL 2004-2005 Internal Medicine PGY-1 Preliminary Year. Technical experience: Cardiology, Gastroenterology, Hematology/Oncology, Endocrinology, Emergency Medicine. Rush Medical College, Chicago, IL 2000-2004 Doctor of Medicine University of Illinois at Chicago, Chicago, IL 1994-1999 BS Degree in Biology and History. RESEARCH Northwestern University, Feinberg School of Medicine, Chicago, IL Laboratory of Dr. Gayle Woloschak. Work with radiation inducible TiO2-DNA nanocomposites. 2004-present Techniques: cloning, autoradiography, cDNA libraries, gene promoter investigation using fluorescent protein reporter genes, SDS-PAGE, gene sequencing, western blot, southern blot, cell/tissue culture, ELISA, COMET assay. Rush University Medical Center, Department of Radiation Oncology, Chicago, IL 2003–2004 Clinical research on locally advanced breast cancer and patient quality of life following prostate cancer brachytherapy. Rush University Medical Center, Department of Surgery, Chicago, IL 2002-2003 Clinical breast cancer research with Dr. Atul Madan. Rush University Medical Center, Department of Orthopedic Surgery, Chicago, IL 2001 Rush University Medical Center, Department of Orthopedic Surgery. Techniques: histologic evaluation of elbow capsule specimen with bright-field, polarizing microscopy and IHC staining. Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 1999-2001 Pediatric oncology research looking at various inhibitors of angiogenesis. Techniques: cell and tissue culture, DNA blotting, and PCR experiments, among other laboratory techniques. University of Illinois at Chicago Cancer Center, Department of Molecular Genetics, Chicago, IL 1997-1999 Basic science research investigating the ability of various oncogenes to regulate DNA double-strand break-induced homologous recombination and cell sensitivity to ionizing radiation. Techniques: western blot, northern blot, southern blot, lab animal care, cell culture, ELISA, PCR, cDNA library. University of Illinois at Chicago College of Medicine, Department of Pathology, Chicago, IL 1996-1997 Atherosclerosis research preparing slides, performing immunohistochemical experiments, and lab animal dissection. University of Illinois at Chicago College of Medicine, Department of Bioengineering, Chicago, IL 1996-1997 Assisted in writing of grant proposals for research on acute phase proteins and cryopreservation of skin graft tissues. TEACHING EXPERIENCE Clinical Didactics Instructor, Northwestern University School of Radiation Therapy 2006-Present PUBLICATIONS, ABSTRACTS, PRESENTATIONS, AND WORKS IN PROGRESS Babbo, A. Kalapurakal, T. Garnett, K. Sathiasellan, V.Kalapurakal, J. Development of pituitary apoplexy following leuprolide injection for treatment of prostatic adenocarcinoma. Being submitted to Images in Urology 10/09. Babbo, A., The Use of Proliferating Cell Nuclear Antigen (PCNA) Protein in Radiation-Mediated Cleavage of Oligonucleotides by Titanium DioxideDNA Nanocomposites In Vitro. Presented at the 12th Annual International Alexandria Clinical Oncology Conference, in Alexandria, Egypt, Jan 2009. Babbo, A. Chokshi, M. Mittal, B. Effectiveness of Radiation Therapy in the Treatment of Patients with Cutaneous T- and B-cell Lymphomas. IRBapproved chart review, 8/28/08-4/1/09. Abstract accepted for 2009 annual American Society of Clinical Oncology (ASCO) meeting. Szolc, B. Paunesku1, T. Lu, J. Cruz, C. Babbo, A. Haley, B. Wanzer, B. Flores, L. Jakubczak1, D. Mishra, M. Templeton, I. Pearlman, A. Bigio, E. Hlatky, L. Woloschak, G. Perturbations in protein expression, apoptosis and cell cycle in the immune tissues of wasted mice before and after γ-irradiation. Manuscript submitted to the International Journal of Radiation Biology in December 2008. Wu, A. Paunesku, T. Brown, E. Babbo, A. Cruz, C. Aslam, M. Dravid, V. Woloschak, G. Titanium Dioxide Nanoparticles assembled by DNA molecules hybridization and loading of DNA interacting proteins. NANO: Brief Reports and Reviews. Vol.3, No.1 (2008) 27-36. Sejpal, S. Koneru, N. Babbo, A. Cruz, C. Paunesku, T. Woloschak, G. Increased expression of proliferating cell nuclear antigen (PCNA) in irradiated PC12 cells with overexpressed heterogeneous ribonuclear protein K (hnRNP K). Abstract presented at the annual ASTRO meeting in 11/ 2006. Babbo, A. Paunesku, T. Link, J. Cruz, C. Wong, Y. Woloschak, G. The Role of Proliferating Cell Nuclear Antigen (PCNA) Protein in RadiationMediated Cleavage of Oligonucleotides by Titanium Dioxide - DNA Nanocomposites In Vitro. Abstract presented at ASTRO Translational Research Symposium in Boston in 9/2006, also presented at ASTRO annual meeting in 11/2006. Madan AK. Sapozhnik J. Babbo A.M. Beech DJ. Clinical versus pathologic assessment of pre-operative breast cancer size. Archives of Surgerysubmitted for publication November 2006. Babbo, A., Intracellular localization and radiation induced cleavage of titanium dioxide DNA nanocomposites. Presented at the International Institute for Nanotechnology in April 2006. Babbo A., Paunesku T, Link J, Woloschak G. The role of proliferating cell nuclear antigen (PCNA) protein in radiation-mediated cleavage of oligonucleotides by titanium dioxide-DNA nanaocomposites. Presented at the International Radiation Oncology Translational Research Conference in Lugano, Switzerland, March 2006. Paunesku, T. Flores, L. Protic, M. Cruz, C. Petrikas, J. Shivnani, A. Babbo, A. Hlatky, L. Woloschak, G. In vivo and in vitro activity of mutant PCNA promoter from radiation sensitive wasted mice. Abstract presented at the 2005 annual Radiation Research Society meeting. Petrikas, J. Shivnani, A. Cruz, C. Babbo, A. Paunesku, T. Woloschak, G. Differential response to irradiation of wild-type proliferating cell nuclear antigen (PCNA) promoter and mutant PCNA promoter from radiation sensitive wasted (wst) mice. Abstract presented at 2005 annual Radiation Research Society meeting. Khan A. Dickler A. Marcus E. Coon J. Ali A. Babbo A. Gupta-Burt S. Clinical outcome correlation of positron emission tomography (PET) in patients with locally advanced breast cancer (LABC) treated with neoadjuvant doxorubicin and docetaxel. Abstract presented at the annual American Society for Therapuetic Radiology and Oncology (ASTRO) meeting, October 2003. Madan AK. Sapozhnik J. Babbo A.M. Posner M. Beech DJ. Education of medical students in clinical breast examination during surgical clerkship. American Journal of Surgery; 184(6):637-640; discussion 641, 2002 Dec. Huang D. Rutkowski JL. Brodeur GM. Chou PM. Kwiatkowski JL. Babbo A. Cohn SL. Schwann cell-conditioned medium inhibits angiogenesis in vitro and in vivo. Medical & Pediatric Oncology; 35(6):590-2, 2000 Dec. Huang D. Rutkowski JL. Brodeur GM. Chou PM. Kwiatkowski JL. Babbo A. Cohn SL. Schwann cell-conditioned medium inhibits angiogenesis. Cancer Research. 60(21):5966-71, 2000 Nov 1. Li W. Hesabi B. Babbo A. Pacione C. Liu J. Chen DJ. Nickoloff JA. Shen Z. Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein. Nucleic Acids Research. 28(5):1145-53, 2000 Mar 1. Babbo, A. Regulation of the self-association of RAD 52 by UBC9 protein in a yeast three-hybrid system. Presented at the Midwest Regional Conference of the National Biological Honor Society, April 1999. HONORS/AWARDS Residency: Cancer Education Consortium Molecular and Translational Oncology Research Workshop Travel Award, ASTRO Translational Research Symposium Travel Grant, Goldberg Research Award. Medical School: Rush University Scholarship, McGaw Scholarship, Raymond Morris Endowment Scholarship. Basic Laparoscopic Skills Certification. Clinical Rotation Honors: Radiation Oncology, Internal Medicine, Internal Medicine Subinternship, Urology, Radiology, Psychiatry. Undergraduate: American Cancer Federation Scholarship Award, National Biological Honor Society research grant recipient, Chancellor’s Student Service Award, President of Beta Beta Beta Biological Honor Society. PROFESSIONAL AFFILIATIONS American Society for Therapeutic Radiology and Oncology, American College of Radiation Oncology, American Society of Clinical Oncology, American Brachytherapy Society, American Medical Association, American College of Radiology, Radiological Society of North America, Association of Residents in Radiation Oncology, Physicians for Human Rights.