Si Jun Zi Tang – The Four Gentlemen Alex Owen BSc. (Hons) TCM, Bachelor of Medicine (Beijing), MATCM 22nd April 2003 Introduction Herbal Formulary is a method of treating disease by administering individual herbs in specific combinations called formulae. The content of each formula is governed by the symptoms presented by the patient which the practitioner is able to classify into a syndrome. Once the syndrome is identified a treatment method is deduced that aims to deal with the symptoms and reinstate balance, returning the patient to health. A formula that best meets the demands of the treatment theory can then be selected. The four aspects of ‘herbs’, ‘formula’, ‘treatment theory’ and ‘syndrome differentiation’ are all intertwined. So much so that even a minor alteration in one will lead to necessary modification of the others in order for the treatment to be successful. This article will investigate this interrelationship by showing how changes in the syndrome necessitate modification of formulae. Changes in Syndrome Differentiation As explained above if there is a change in the presentation of a disease the syndrome differentiation will alter, this in turn will lead to a reworking of the treatment method which will finally end by the modification of a formula by the altering of its components. If the disease changes or an inaccurate syndrome differentiation is made, there will be a high probability that the formula selected will have a diminished effect or be totally ineffective. Therefore it is crucial that accurate diagnosis is made and that all symptoms are taken into account. This article will use the formulae Si Jun Zi Tang to illustrate how even minor changes in the syndrome will lead to modification of the formula. 四 君 子 汤 (Si Jun Zi Tang) Si Jun Zi Tang is translated as the ‘Four Gentlemen Decoction’, it was given this name as the herbs within the formula have a mild and balanced action of tonifying the qi. It is indicated for use in cases of spleen and stomach qi deficiency syndrome. This syndrome means that the spleens ability to transform food into blood is deficient leading to symptoms of pallor, and a low soft voice. The deficient function of the spleen also means that its duty of transporting is inadequate manifesting as poor appetite and loose stools. The spleen is also responsible for maintaining the four limbs, with insufficient supply of nutrition from the spleen the muscles will become weak, and the patient becomes lethargic. A pale tongue and a soft and weak pulse will 22/04/03 Herbal Formulary Alex Owen also be exhibited. These symptoms can appear in such biomedically-defined disorders as chronic gastritis, diabetes mellitus and peptic ulcer. The formula is made up of four herbs. Ren Shen is the principal herb, with a sweet and warm nature, it is a strong tonic invigorating the spleen qi. Bai Zhi, the assistant herb, is bitter, sweet and warm and is able to strengthen the spleen, dry dampness and harmonises the spleen and stomach. Ren Shen and Bai Zhi work synergistically to promote the transforming and transporting functions of the spleen. Fu Ling, the adjuvant herb, is sweet and bland. It excretes dampness while supporting the function of Ren Shen and Bai Zhi in strengthening the spleen. Finally Zhi Gan Cao, the dispatcher herb, is sweet and warm and helps to nourish the spleen, replenish qi and harmonise all the herbs in the formula. 香 砂 六 君 子 汤 (Xiang Sha Liu Jun Zi Tang) The syndrome of spleen and stomach qi deficiency with cold-damp stagnating in the middle jiao presents symptoms that necessitate the basic formula of Si Jun Zi Tang to be modified. In combination with symptoms of spleen qi deficiency, the cold causes coagulation of qi and blood within the middle jiao impeding its flow and causing pain and distension in the abdomen. In addition the ability of the spleen to transform water is diminished leading to an accumulation of dampness overflowing from the stomach and further impeding the flow of qi around the chest and middle jiao. The stomach qi is no longer harmonised, it adversely rises leading to belching, nausea and sometimes vomiting. The dampness also flows downward causing loose stools. Si Jun Zi Tang does not have herbs that can directly deal with the causes of these additional symptoms so four herbs are added to the original formula to form Xiang Sha Liu Jun Zi Tang. Ban Xia and Chen Pi are the two main herbs from the formula Er Chen Tang which specifically deals with phlegm-dampness due to spleen qi deficiency. Together they are able to dry the dampness, regulate and lower the adverse qi, harmonising the stomach to stop vomiting. Alone they are not enough to stop all of the symptoms though, so Mu Xiang and Sha Ren are also added. Mu Xiang promotes the movement of spleen and stomach qi to alleviate abdominal pain and distension, promote appetite and stop nausea and vomiting. Sha Ren transforms dampness that is impeding the spleen and stomach and promotes the movement of qi strengthening the stomach. Together they have a strong action to regulate the qi to alleviate pain and distension in the abdomen, which is the key differentiating symptom of this syndrome. The four additional herbs all help to expel the cold-damp, regulate the qi and strengthen the middle jiao. 參 苓 白 术 散 (Shen Ling Bai Zhu San) Spleen qi deficiency leading to internally generated dampness is a condition again stemming from spleen qi deficiency. The presentation has very similar symptoms as the previous formulae yet subtle differences. Again this calls for modification of Si Jun Zi Tang. 2 22/04/03 Herbal Formulary Alex Owen The weakened transforming function of the spleen leads to the accumulation of fluids which transform into dampness in the middle jiao. Distension and a stifling sensation are encountered in the chest and epigastrium due to the dampness obstructing the flow of qi. The dampness also travels downward causing diarrhoea. These symptoms are encountered in addition to the symptoms of spleen qi deficiency. Shen Ling Bai Zhu San’s primary focus is to tonify the spleen and Si Jun Zi Tang is incorporated to achieve this. In addition, other herbs are present to excrete the dampness, replenish the qi and stop diarrhoea. Shan Yao, Yi Yi Ren, Bai Bian Dou and Lian Zi support the functions of Bai Zhu and Fu Ling by strengthening the spleen, helping to excrete dampness and stopping diarrhoea. Sha Ren is added to assist the transformation of dampness and promotes the movement of qi to alleviate the distension and stifling sensation. Finally Jie Geng helps protect the lungs from deficiency, which is often a sequela of spleen deficiency. 理 中 丸 (Li Zhong Wan) The syndrome of deficient cold in the spleen and stomach sees cold encroaching the middle jiao due to deficiency of spleen yang. Clear yang is unable to ascend causing diarrhoea and turbid yin does not descend inducing vomiting and nausea. The cold entering the abdomen causes an absence of thirst and induces contractions, which in turn causes pain. Due to the lack of functional activity of the spleen, its transporting function is not carried out and appetite is reduced. Although the presentation of the symptoms is similar to spleen qi deficiency the underlying cause is different and Si Jun Zi Tang must be modified to effectively deal with the new syndrome. Li Zhong Wan places Gan Jiang as the principal herb and removes Fu Ling. Gan Jiang is pungent and hot and has the action of warming the spleen and stomach and expelling cold. Gan Jiang is able to combine with Ren Shen to stop vomiting due to cold, Bai Zhu to stop diarrhoea and Gan Cao to ease epigastric pain and vomiting due to cold. Conclusion Si Jun Zi Tang is an exceptionally versatile formula, which is incorporated into many different formulae. Treating a range of syndromes from spleen qi deficiency to qi and blood deficiency and even deficiency of yang. These formulae cannot all be looked at in this article, so a few have been chosen to demonstrate how changes in formula are necessary if changes in syndrome occur, whether they be small or large. Although deficient spleen function is best treated with Si Jun Zi Tang, the variation in the extent of this deficiency and the symptoms that arise from it, demand that the formula be modified to effectively treat the condition. The key is accurate diagnosis, the identification of the correct syndrome differentiation and an effective treatment strategy. The syndromes identified above, 3 22/04/03 Herbal Formulary Alex Owen on the surface may appear to have very similar symptoms. Most have poor appetite, nausea, vomiting and possibly some discomfort in the abdomen. However it has been demonstrated that although the symptoms may appear to be the same, the factor that causes them can change. With this change in syndrome the treatment strategy must be modified leading to an inevitable change in the component of the formula. If the physician is not thorough in his diagnosis it will be easy to misdiagnose the syndromes, which will lead to a formation of an inaccurate differentiation and treatment strategy. If Si Jun Zi Tang is chosen to treat the other syndromes it may have diminished effect, or nearly no effect at all in the case of attempting to treat deficient spleen yang. This emphasises the interconnection between the four aspects of formulary. For without accurate differentiation of the syndrome allowing the practitioner to arrive at the correct treatment strategy, the correct herbs cannot be selected to form the most effective treatment for the patient. Bibliography Bensky D. and Barolet R. (1990). Chinese Herbal Medicine Formulas and Strategies. Seattle: Eastland Press Bensky D. and Gamble A. (1986). Chinese Herbal Medicine Materia Medica. (9th ed). Seattle: Eastland Press Geng J.Y. (1996). Herbal Formulas. (2nd ed). Beijing: New World Press Liu Z.W. and Jiang Y.A. (1998). Formulas of Traditional Chinese Medicine. Beijing: Academy Press Meng Y.F. (1998). Diagnostics of Traditional Chinese Medicine. Beijing: Academy Press Qiao Y. (2000). The Traditional Chinese Medicine Formula Study Guide. Boulder: Snow Lotus Qu J.F., Zhang S.H. and Xie R. (1990). The Chinese Materia Medica. Shanghai: Publishing House of Shanghai College of Traditional Chinese Medicine The author wishes to remind readers that no one reading this article should try to diagnoses themselves or take herbal formula unless they have been prescribed by a professional Chinese medicine practitioner. 4