16th ISAP International Symposium
PK-PD to Streamline Anti-Infective Development
(a post-ICAAC 2006 meeting)
Saturday September 30th, 2006 - 1:00 - 6:00 pm
Meeting location: San Francisco Marriott
Meeting room: Sierra C
12:00-1:00pm
ISAP Business Meeting
1:00-2:00pm
Open Discussion
The relevance of lung concentrations
Ursula Theuretzbacher
CEnter For Anti-Infective Agents, Vienna, Austria
2:00-2:30pm
The TLAs of antibiotic development: Can PD lead to better ROI?
Glenn Tillotson
Replidyne, Boulder, CO
2:30-6:00pm
Importance of Intersubject Variance in Plasma Protein Binding in Monte Carlo
Simulation (MCS)
A Forrest, CM Rubino, SM Bhavnani, GL Drusano, PG Ambrose
ICPD, Ordway Research Institute, Albany, NY and SUNY-Buffalo School of Pharmacy,
NY.
Plasma protein binding DOES influence bacterial killing by fluoroquinolones –
investigation by use of an improved method
M. A. Zeitlinger, F. Traunmüller, Robert Sauermann and C. Joukhadar
Medical University of Vienna, Austria
PK/PD challenges of in vitro time-kill curves – a new modeling approach
S. Schmidt, O. Burkhardt, W. Treyaprasert, H. Derendorf
University of Florida, Gainesville, FL
Bactericidal Activity of API-1252, A Novel Bacterial Enoyl-ACP Reductase
Inhibitor, against Staphylococcus aureus in an in vitro Pharmacodynamic Model.
Yoriko Harigaya, Brian T. Tsuji, Patrick F. Smith, David Vaughn, Nachum Kaplan, Alan
Forrest
University at Buffalo, Buffalo, NY and Affinium Pharmaceuticals Inc., Toronto, Canada
Estimation of standard dose of pivampicillin for upper-respiratory tract infection
(URTI): Monte Carlo simulation of oral antibiotic PK/PD
Klaus Skovbo Jensen, Niels Frimodt-Møller
Statens Serum Institut, Copenhagen, Denmark
PK/PD Evaluation of the Antimicrobial Activity & Production of -lactamase when
Sulbactam is Added to Cefepime (CFP) & Ceftazadime (TAZ) Against Pseudomonas
aeruginosa (PsA)
S McCabe, E Hudzinski, BT Tsuji, PA Kelchlin, PF Smith
University at Buffalo School of Pharmacy, Buffalo, NY
No Immunomodulatory Effect of Fosfomycin in Experimental Endotoxemia in
Humans
Robert Sauermann,Claudia Marsik, Ilka Steiner, Katja Seir, Tuende Civtko, Markus
Zeitlinger, Bernd Jilma, Christian Joukhadar
Medical University of Vienna, Austria.
Pharmacokinetics and Hematologic Toxicodynamics of Linezolid in a Typical Patient
Population
L. M. Boak, C. R. Rayner, M. L Grayson, D. Spelman, D. L. Paterson, S. Melvani, B.
Capitano, A. Forrest, J. Li, R. L. Nation
Monash Univ., Austin Hosp., Alfred Hosp., Melbourne, Australia; Univ. of Pittsburgh
Med. Center, Pittsburgh, PA, USA; Univ. at Buffalo, Buffalo, NY, USA
Predictions of Vancomycin Exposure Based on Sparse Data or Demographics Alone
Jenny C. Yang, Alan Forrest, and Pam Moise-Broder
SUNY Buffalo,, NY and Univ. of the Pacific, School of Pharmacy, Stockton, CA.
Herb-drug interaction involving Garcinia kola seed and either ofloxacin or
ciprofloxacin: In vitro pharmacodynamic and pharmacokinetic evidences
Esimone C and Adikwo M
Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
Attenuated Vancomycin Bactericidal Activity in Staphylococcus Aureus HemB
Mutants Expressing the Small Colony Variant Phenotype
Brian. T. Tsuji, Christof Von Eiff , Patrick F. Smith, Pam A. Kelchlin, Alan Forrest
SUNY Buffalo, NY and Inst. of Med. Microbiol., Univ. of Münster, Germany.
PK/PD of dicloxacillin against extra- and intracellular S. aureus in vivo
A. Sandberg, J.H.R. Hessler, R.L. Skov and N. Frimodt-Moller
Statens Serum Institut, Copenhagen, Denmark
A Population Approach to Modeling the Pharmacodynamic Effects of Telavancin’s
in vitro Activity against Staph auerus using MCPEM
Olanrewaju O. Okusanya, Alan Forrest, Brian Tsuji, and Patrick Smith
SUNY Buffalo, School of Pharmacy, Buffalo, NY
MIC, Time-kill Studies and Simultaneous PAFE Experiments of Voriconazole
against Clinical Strains of Candida
Y. Li, C.J. Clancy, M. Nguyen, H. Derendorf
University of Florida, Gainesville, FL
Broad spectrum antiviral fraction from the lichen, Ramalina farinacea
Esimone C, Grunwald T, Kuate S, Tippler B, Proksch P and Überla K.
Ruhr-University, Bochum and University of Düsseldorf, Germany.