ACVR WRITTEN EXAMINATION OBJECTIVES 2008 INTRODUCTION Each of the six sections of the written examination objectives is designed to provide an ACVR eligible resident with a framework from which to study. The objectives are not all inclusive but should provide a minimum knowledge base needed to pass the written examination. A candidate must complete all sections of the written examination during one test period with a minimum of 70% correct responses in each section. A candidate failing only one section may retake the failed section during one of the next two test periods. The candidate will be allowed one attempt to retake and pass the re-examination within the allowed period. If unsuccessful, then he-she must retake the entire written examination. Candidates who fail more than one section must retake the entire written examination. The six-section written examination is given over two days at the location of any member of the Examination Committee or at other locations as approved by Executive Council. These sections include: 1.) Anatomy, 2.) Physiology and Pathophysiology, 3.) Physics of Diagnostic Radiology, 4.) Radiobiology and Radiation Protection, 5.) Physics and Applications of Alternate Imaging and, 6.) Special Procedures. The examination tests entry level knowledge in these six subject areas. A candidate should expect questions using true/false, multiple choice, and image or schematic identification. For the foreseeable future, the format of the examination will transition to a multiple choice format with questions of other types being phased-out. Images will be used in the examination and may include normal or abnormal cases. While emphasis is given to the dog, cat and horse, other species will be included where appropriate and noted. The current literature relevant to examination sections and diagnostic imaging is a source of examination material. In addition, past literature pertinent to specific radiographic techniques, special procedures, radiobiology and alternate imaging are used for questions. While there is no stated specific time limit regarding the literature, particularly for Veterinary Radiology & Ultrasound, outdated, obsolete, or obscure material is avoided. ANATOMY The candidate will be required to have an understanding of the following: 1. General 1.1. Current anatomic nomenclature will be used in questions and expected in answers. 1.2. Candidates must be familiar with ACVR-approved terminology 2. General Musculoskeletal System (canine, feline and equine) 2.1. General bone formation and growth. 2.2. Ages at which ossification centers fuse 2.2.1. Long bones including vertebral column 2.3. Blood supply of long bones 2.3.1.1.immature and mature Written Objectives - 2008 Last saved on: 2/15/16 Page 1 2.3.1.2.differences in large animal versus small animal immature long bone blood supply 3. . Axial Skeleton (canine, feline and equine) 3.1. Topographic features of vertebrae in all spinal segments. 3.2. Topographic features of bones of the skull and mandible as well as dentition and how dentition changes with age 3.3. Sinuses, sinus communications and relationships 3.4. Topographic features of the pelvis 3.5. Formulae for the vertebral column, sternum and ribs (including cows) 4. Appendicular Skeleton (canine, feline and equine) 4.1. Topographic features of the long bones and joints as seen on radiographs (including avian) 4.2. Proximal and distal attachments of the major muscles, tendons, and ligaments associated with the thoracic and pelvic limbs. 4.2.1. On radiographs of the thoracic and pelvic limbs, understand the topographic features of the skeleton relative to the proximal and distal attachments of major muscles, tendons, and ligaments 4.2.2. Understand both radiographic and cross-sectional anatomy and relationships 4.3. Transverse and sagittal anatomy of the equine distal extremity, metacarpus/tarsus, common calcaneal and biceps tendons as it pertains to ultrasound imaging (canine and equine). 5. Arthrology (canine, feline and equine) 5.1. Classification and topographic features of joints of the head, vertebral column and limbs 5.1.1. Relationship, structure and function of ligaments and intervertebral discs of the vertebral column 5.1.2. Presence and function of menisci 5.2. Sesamoid bones and their relationship to the joints 5.3. Understanding of the structures that are accentuated on various radiographic projections (e.g. flexed lateral-medial carpus) 5.4. Comparative arthrology of the bones and joint compartments for the stifle, carpus and tarsus 6. Cardiovascular System (canine, feline and equine) 6.1. Embryology of the cardiovascular system to understand the development of common malformations of the heart and great vessels 6.2. Differences between fetal and neonatal circulation 6.3. Arteries arising from aortic arch and common congenital malformations 6.3.1. double aortic arch, persistent right aortic arch, aberrant left subclavian and aortic coarctation 6.4. Vascular supply to the brain 6.5. Vertebral vascular system 6.6. Branches of the abdominal aorta 6.7. Blood supply of the canine and feline liver, spleen, kidneys, and pancreas Written Objectives - 2008 Last saved on: 2/15/16 Page 2 6.8. Blood supply to thoracic and pelvic limbs 6.8.1. major arterial blood supply and venous drainage 6.8.2. understand supply from aorta to manus/pes and drainage to the cranial or caudal vena cava 6.9. Portal venous system (hepatic) 6.9.1. normal and congenital/acquired shunting 6.9.2. patent ductus venosus 6.9.3. single extra-hepatic portosystemic shunts 6.9.4. Normal and abnormal angiographic studies of the hepatic portal circulation 6.10. Echocardiographic anatomy in standard right and left parasternal short and long-axis planes 6.11. Common cardiac developmental anatomy 6.11.1. patent ductus arteriosus 6.11.2. atrial and ventricular septal defects 6.11.3. valvular stenosis 6.11.4. atrioventricular dysplasias 6.11.5. endocardial cushion defects and conotruncal defects 6.11.6. Tetralogy and pentalogy of Fallot 6.11.7. persistent left cranial vena cava 6.11.8. Normal and abnormal, selective and non-selective angiocardiography 7. Nervous System (canine, feline and equine) 7.1. Anatomical relationships of spinal cord, spinal nerves and meninges 7.1.1. brachial and lumbosacral plexes 7.1.2. major components and innervations of the nerves that originate from these plexes 7.2. Segmental spinal nerve origins, location of exit from the vertebral canal and the function of the spinal nerves. 7.3. Ventricular system of the brain and its drainage 7.4. Distribution of nerves in the distal extremity of the thoracic and pelvic equine limbs as related to common nerve blocks performed 7.5. Anatomy of the brain, brain stem, including the cranial nerves and spinal cord that can be recognized with cross-sectional imaging (CT, MRI or US) 7.6. Routine radiographic anatomy of the skull 7.7. General understanding of neurologic examination and lesion localization 7.8. Origin of cranial nerves and their function 7.9. Anatomy of the organs of special sense 8. Digestive System (canine, feline and equine) 8.1. Normal anatomic relationships of gastrointestinal tract with all other abdominal organs (including bovine) 8.2. Comparative anatomy of the ileo-ceco-colic region 8.3. Anatomy of the liver, gallbladder, and pancreas 8.3.1. Comparative anatomy of the bile duct and pancreatic ducts 8.4. Normal sonographic anatomy of the gastrointestinal tract 9. Respiratory System (canine, feline, equine) 9.1. Oropharynx, nasopharynx, laryngeal cartilage and hyoid apparatus Written Objectives - 2008 Last saved on: 2/15/16 Page 3 9.2. Guttural pouches and their anatomic relationships as viewed on routine radiographs and computed tomography or magnetic resonance – equine 9.3. 9.4. Bronchial tree and lung lobes – compare between species 9.5. Vascular supply of the lung 9.6. Pleural layers 9.7. Mediastinal anatomy and degree of development/fenestrations 9.8. Avian air sac anatomy and connection with primary pulmonary structures (airways, lung, etc.) 10. Urogenital (canine, feline, equine) 10.1. Anatomy of the kidney, ureter, and lower urinary tract and the relationship to reproductive organs 10.1.1. Identification of normal or abnormal structures using, contrast enhanced radiographic or Covered in alt. imaging 10.2. Embryology of the urogenital system 10.2.1. development of the kidney, ureters, and urinary bladder 10.2.2. development of gonadal structures 10.2.3. Malformations of the urogenital system including ectopic ureter, pseudohermaphrodites, renal agenesis, uterus masculinus, and cryptorchidism. 10.3. Avian normal urogenital anatomy 11. Miscellaneous (canine, feline, equine) 11.1. Positioning and postural influences on the radiographic appearance of the thorax and abdomen 11.2. Effects of inhalation vs. exhalation on anatomic relationships and appearances 11.3. Location of lymph nodes and drainage patterns 11.4. Cross-sectional and sagittal anatomy of the thorax and abdomen Written Objectives - 2008 Last saved on: 2/15/16 Page 4 12. PHYSIOLOGY/PATHOPHYSIOLOGY 12. Physiology and Pathophysiology of Specific Organ Systems 12.1. Alimentary 12.1.1. Physiologic mechanisms of gastro-intestinal tract function (oral, esophageal, gastric, intestinal, colonic) 12.1.1.1. Propulsion and bolus formation, esophageal and intestinal motility 12.1.1.2. Hormonal control and alimentary reflexes (e.g., gastrocolic) as they apply to motility and secretion control 12.1.2. Vomiting vs. regurgitation – applicable pathophysiology 12.1.3. Diarrhea - applicable pathophysiology related to small intestinal versus large intestinal diarrhea 12.1.4. Transit times in normal and disease states 12.1.5. Ileus 12.1.5.1. Causes and types – mechanical vs. functional 12.1.5.2. Pathophysiology 12.1.6. Gastric dilatation/torsion/volvulus complex 12.1.6.1. Possible etiologic factors 12.1.6.2. Systemic and local pathophysiologic alterations 12.1.6.3. Basis of radiographic appearance 12.1.7. Pancreas 12.1.7.1. Normal exocrine and endocrine physiology 12.1.7.2. Pathophysiology of pancreatitis and pancreatic tumors 12.1.7.3. Pathophysiology of endocrine diseases associated with the pancreas 12.1.8. Hepatobiliary System 12.1.8.1. Normal physiology 12.1.8.2. Pathophysiology of acute and chronic hepatitis, cholangiohepatitis, cholecystitis, obstructive biliary disorders, biliary rupture and peritonitis, hepatic lipidosis 12.2. Cardiovascular System 12.2.1. Hemodynamics, flow, timing, and pressure relationships 12.2.2. Origin, source and significance of heart sounds as well as normal values for cardiac pressures and blood gas evaluations – moved from Specials 31.2.3 12.2.3. Interrelationship and correlation of the above for the normal cardiac cycle and for abnormal cardiac conditions 12.2.4. Coronary blood flow 12.2.5. Starling's Law of the Heart 12.2.6. Congenital and acquired cardiovascular diseases 12.2.6.1. Common clinical signs 12.2.7. Mechanisms and pathophysiologic effects of congestive heart failure 12.2.8. Pericardial disease and effect on cardiac function 12.2.9. Pathophysiology of canine and feline heart worm infection 12.2.9.1. Cardiopulmonary effects 12.2.10. Vascular anomalies-hemodynamics: clinical signs and pathophysiology 12.2.10.1. Portosystemic shunts Written Objectives - 2008 Last saved on: 2/15/16 Page 5 12.2.10.2. Arteriovenous malformations 12.2.10.3. Infarction of major vessels and downstream organ 12.2.10.4. Aortic and venous embolism/thrombus 12.2.11. Lymphatic system 12.2.11.1. Physiology of lymphatic production and flow 12.2.11.2. Pathophysiology of diseases of the lymphatic and mononuclear phagocytic systems 12.3. Central Nervous System 12.3.1. Spinal cord 12.3.1.1. Pathophysiology of common causes of localized spinal cord disorders including, but not limited to: intervertebral disc disease, hemorrhage, fibrocartilaginous embolism, neoplasia, developmental disorders. 12.3.1.2. Embryonic derivation of spinal and vertebral components germane to clinically encountered congenital disease 12.3.2. Brain 12.3.2.1. Production and flow of cerebrospinal fluid 12.3.2.2. Cerebral vascular accidents/infarctions 12.3.2.3. Characteristics of canine and feline brain tumors. 12.4. Musculoskeletal System 12.4.1. Bone 12.4.1.1. Physiologic sequence and mechanism of normal fracture healing 12.4.1.2. Pathophysiology of bone disease 12.4.1.2.1. metabolic and congenital diseases 12.4.1.2.2. abnormal fracture healing (non-union, delayed union, malunion) 12.4.1.2.3. infection of bone 12.4.1.2.4. bone infarcts and avascular necrosis 12.4.1.2.5. periosteal and periarticular new bone formation 12.4.2. Cartilage 12.4.2.1. Physiology of cartilage growth, development and repair 12.4.2.2. Pathophysiology of osteochondrosis and osteochondritis dissecans 12.4.3. Joints 12.4.3.1. Normal physiology 12.4.3.2. Pathophysiology of degenerative joint disease, including radiographic features of degenerative joint disease and an understanding of how each of the described changes occur 12.4.3.3. Pathophysiology of immune-mediated, infectious, and traumatic joint disease 12.5. Respiratory System 12.5.1. Normal respiration 12.5.1.1. Deleted 2008 12.5.1.2. Lung perfusion and physiologic responses to lung diseases 12.5.2. Methods of oxygen and carbon dioxide transport Written Objectives - 2008 Last saved on: 2/15/16 Page 6 12.5.2.1. General understanding of the blood gas profile (pH, PO2, pCO2, HCO3, base excess/deficit) 12.5.2.2. Normal physiology of pleural fluid formation. 12.5.3. Abnormal respiration 12.5.3.1. Common causes of respiratory dysfunction including dyspnea and stridor and their pathophysiologic effects on the thoracic wall, pleural space, upper respiratory system and bronchi, lungs, pulmonary vasculature and diaphragm. 12.5.3.2. Pathophysiology of pulmonary thromboembolism 12.5.3.3. Pathophysiology of pleural effusions 12.6. Urogenital System 12.6.1. Renal function 12.6.1.1. Mechanism of urine production 12.6.1.2. Methods of renal function assessment 12.6.1.3. Interpretation of abnormal renal function tests (BUN, creatinine, note species differences between canine, feline and equine) 12.6.1.4. Role of the kidney in the maintenance of blood pressure/electrolytes 12.6.1.5. Renin-angiotensin-aldosterone pathways 12.6.1.6. Erythropoietin and endocrine functions 12.6.2. Organ, hormonal and mineral inter-relationships 12.6.2.1. Interrelations of kidneys, liver, intestine, bone, parathyroid and thyroid gland on Vitamin D, calcium and phosphate regulation 12.6.2.2. Alterations of the above due to disease 12.6.3. Abnormal renal function 12.6.3.1. Acute vs. chronic renal failure 12.6.3.2. Glomerulonephritis 12.6.3.3. Interstitial nephritis 12.6.3.4. Toxicities 12.6.3.5. Infections 12.6.3.6. Neoplasia 12.6.3.7. Pyelonephritis 12.6.3.8. Feline lower urinary tract disease 12.6.4. Pressure, volume relationship among the ureters, bladder and urethra; neurophysiology of micturition, the detrusor reflex and vesicoureteral reflux 12.6.5. Genital 12.6.5.1. Radiographically recognizable fetal ossification intervals (canine and feline) 12.6.5.2. Radiographic findings of fetal death and how the signs develop (dog and cat) 12.6.5.3. Canine pyometra – pathogenesis, predisposing causes, systemic effects 12.6.5.4. Ovarian disease – congenital, neoplastic, and functional problems, systemic effects 12.6.5.5. Prostate gland diseases 12.6.5.6. Testicular diseases Written Objectives - 2008 Last saved on: 2/15/16 Page 7 12.7. Endocrine System 12.7.1. Thyroid Gland 12.7.1.1. Iodide trapping and organification into T3/T4 12.7.1.2. Deleted 2008 12.7.1.3. Pituitary-thyroid axis - homeostasis and negative feedback 12.7.1.4. Thyroid hormone function and effects on other organ systems 12.7.1.5. Mode of action/duration of antithyroid medications 12.7.1.6. Systemic effects of I-131 in cats treated for feline hyperthyroidism. 12.7.2. Pituitary Gland 12.7.2.1. Homeostasis and regulation of pituitary gland via portal system and releasing factors/proteins or neurohypophyseal control of posterior pituitary 12.7.2.2. Pituitary disease – Cushing’s syndrome, tumors, diabetes insipidus, and hypoplasia 12.7.3. Adrenal Gland 12.7.3.1. Epinephrine and norepinephrine production and regulation 12.7.3.2. Tumors of the adrenal cortex and medulla 12.7.3.3. Glucocorticoids - control and effects 12.7.3.4. Hyperadrenocorticism and hypoadrenocorticism 12.7.3.5. Hyperaldosteronism 12.7.3.6. Mineralocorticoids - control and effects 12.7.3.7. Physiologic effects of adrenal hormones on CNS, cardiovascular system, respiratory system and metabolic status 12.8. Miscellaneous 12.8.1. Pathophysiologic basis and radiographic findings in immune-mediated diseases: 12.8.1.1. Immune-mediated thrombocytopenia 12.8.1.2. Immune-mediated hemolytic anemia Written Objectives - 2008 Last saved on: 2/15/16 Page 8 13. RADIATION PROTECTION - RADIATION BIOLOGY 13.Physics 13.1. Physics and Chemistry of Radiation Absorption 13.1.1. Differentiate between molecular excitation and ionization. 13.1.2. Differentiate between particulate and electromagnetic (non-particulate) forms of radiation. 13.1.3. Differentiate between the sites of origin of gamma rays and x-rays. 13.1.4. Know the basic forms of particulate radiations and their interactions or potential interactions with matter, including: alpha particles, electrons, protons, and neutrons. 13.1.5. Understand the difference between direct and indirect forms of ionizing radiation injury. 13.1.6. Understand the difference between direct and indirect actions of radiation. 13.1.7. Define the role of ionization and free radical formation and their role in creating biological effects. 13.2. Basic Atomic and Nuclear Physics 13.2.1. Atomic composition and structure and nuclear binding forces 13.2.2. Nuclear decay charts and radioactive decay 13.2.3. Line of stability and the line of unity 13.2.4. Isotopes, Isobars, Isomers and Isotones 13.2.5. Atomic number and atomic mass; calculation of neutron number 13.3. Modes of Radioactive Decay (particulate and non-particulate emissions including neutrinos and anti-neutrinos) 13.3.1. Betatron (negatron) decay 13.3.2. Alpha decay 13.3.3. Electron capture 13.3.4. Positron decay (annihilation reaction and photon formation) 13.3.5. Isomeric transition 13.4. Radioactive Decay terminology 13.4.1. Decay constant and relationship with physical half-life 13.4.2. Physical and biological half-life and the calculation of the effective half-life. Understand the concept of an effective half-life. 13.4.3. Average half-life 13.4.4. Specific activity 13.5. Be familiar with molecular reactions and interactions of radiation with matter. 13.5.1. Deleted in 2008 13.5.2. Understand the concepts of exposure, dose equivalent, absorbed dose, weighting (quality) factor for electromagnetic and particulate radiation. Understand the relationship between roentgens, rads, and rems. 13.5.3. Be able to convert rads to Grays and rems to Sieverts. Written Objectives - 2008 Last saved on: 2/15/16 Page 9 14. Radiation Biology 14.1. Know the basic mechanisms of acute and late radiation injury and cell killing 14.1.1. Understand the differences in radiation response between acute and late responding tissues. 14.2. How does radiation kill cells 14.2.1. Discuss the mechanisms of electromagnetic radiation induced cell killing 14.2.2. Discuss the differences between apoptotic and mitotic cell death related to radiation induced cellular injury 14.2.3. Understand the differences between lethal damage, sub-lethal damage and potentially lethal damage 14.3. Understand the concept of L.E.T. (linear energy transfer) and how L.E.T. relates to R.B.E. (relative biological effectiveness) and the oxygen effect. 14.4. Understand R.B.E. and how R.B.E. may be influenced by other factors. 14.5. Discuss the phases of acute radiation syndrome, including the bone marrow, gastrointestinal and CNS radiation syndromes. 14.5.1. Include the prodromal symptoms, whole body dose to create the radiation syndrome and clinical signs associated with acute radiation syndrome. 14.6. Discuss/be familiar with the effects of chronic radiation exposure 14.7. Be familiar with the effects of radiation on the developing embryo/fetus in utero. 14.8. Understand the meaning of the terms, “lethal dose”, and “tolerance dose”. 14.9. Understand the difference between deterministic and stochastic effects related to radiation induced injury. 15. Oncology/Tumor Biology 15.1. Be familiar with the biological behavior of common canine, feline, and equine tumors. 15.2. These should include common tumors of the skull, oral cavity, nasal cavity and paranasal sinuses, brain, spinal cord and peripheral nervous system, pharynx, respiratory system, circulatory system, appendicular and axial skeleton, integument, gastrointestinal system (including hepatobiliary and pancreatic), urogenital, bone marrow, lymphoid tissues , and connective tissues. 15.3. Common tumor types from these systems should be understood in terms of local invasiveness, metastatic potential and common metastatic appearance and described radiographic appearances based on the literature related to veterinary medicine. 16. Radiation Monitoring 16.1. Be familiar with the equipment and devices used for monitoring radiation and the basic principles involved. 16.1.1. Gas-filled detectors, including the basic principles, ionization chambers, proportional counters and Geiger-Müeller survey meters. 16.2. Be familiar with the appropriate use and limitations of personnel monitoring equipment (TLD monitors, pocket dosimeters and film badges) and interpretation of data obtained. 16.3. Be familiar with the regulations pertaining to personnel monitoring, i.e., occupational, nonoccupational, general population, and fetal exposures 16.3.1. Understand patient versus operator exposure levels 16.3.2. Understand radiation safety factors… time, distance, shielding 16.3.3. Understand the concept of lifetime cumulative exposure Written Objectives - 2008 Last saved on: 2/15/16 Page 10 17. Radiation Protection 17.1. How do you protect yourself and other from different types of radiation? 17.1.1. What is the ALARA concept? 17.2. Understand the principle of barrier design, occupancy, workload, filtration, and beam limiting devices and personnel shielding for the design of radiology rooms and shielding within the room. 17.3. Define and apply ALARA concept to standards of radiation protection and safety. 17.4. Be familiar with the radiation protection aspects of handling animals that have been given either diagnostic (99mTc, 111Indium) or therapeutic radiopharmaceuticals (131I). 17.4.1. Care and handling of the radioisotopes and the radioactive patients 17.4.2. Monitoring external and internal exposure of personnel 17.4.3. Exposure versus contamination 17.4.4. Know the deterministic annual limits for the lens of the eye and localized areas of the skin, hands and feet. 17.5. Regulatory Aspects 17.5.1. Know the function and responsibility of the various councils and agencies, i.e., NRC, NCRP, ICRP, OSHA, and State Governments. 17.5.2.Differences between agreement and non-agreement states Written Objectives - 2008 Last saved on: 2/15/16 Page 11 18. PHYSICS OF DIAGNOSTIC RADIOLOGY 18.History 18.1. Know the history of the discovery of X-rays (briefly) 19. Production of X-rays 19.1. Be familiar with the construction and function of the following components of a diagnostic x-ray system: 19.1.1. Exposure timers: (pros and cons of each type) 19.1.1.1. Deleted 2008 19.1.1.2. Synchronous timers 19.1.1.3. Electronic timers 19.1.1.4. Photo-timer – automatic exposure control 19.1.2. Inherent and added beam filters and collimator 19.1.3. Milliamperage (mA) regulation 19.1.4. Voltage (kVp) regulation 19.1.5. X-ray tube housing and cooling elements 19.1.6. X-ray tube 19.1.6.1. Anode and anode shaft 19.1.6.2. Cathode, cathode filaments and focusing cup 19.1.6.3. Transformer 19.1.6.4. Focal spot size 19.2. Be familiar with the following concepts and understand their relationship and/or importance in x-ray production: 19.2.1. Alternating versus direct current 19.2.2. Bremsstrahlung radiation and polychromatic (energetic) x-ray beam 19.2.3. Characteristic radiation 19.2.4. Characteristics of focal spots including actual vs. effective focal spots, the line focus principle, large versus small focal spots, and requirements for magnification radiography. 19.2.5. Electron orbits and energy levels 19.2.6. Filtration (inherent and added) 19.2.7. Heat dissipation within the tube and tube housing 19.2.8. Anodes: rotating versus stationary, common anode materials, heel effect and anode angle (effect on focal spot size and heel effect). 19.2.9. Voltage wave forms including ripple effect, constant potential, high frequency. Differences between kilovoltage and megavoltage x or gamma rays 19.2.10. mAs, kVp, & keV 19.2.11. kW ratings of x-ray tubes and x-ray generators 19.2.12. Milliamperage (including falling load principle) 19.2.13. Collimators and primary x-ray beam 19.2.14. Rectification 19.2.15. Understand of tube heat units, tube rating charts and anode cooling charts for routine radiology and fluoroscopy units. 19.2.16. Line voltage and line voltage compensator Written Objectives - 2008 Last saved on: 2/15/16 Page 12 19.3. Understand the principles of energy transfer in the production of a useful x-ray beam, including: 19.3.1. Energy transfer at the transformer 19.3.2. Energy transfer at the anode 19.3.3. Energy transfer at the cathode 19.3.4. Energy transfer within the glass envelope and the collimator housing (added filtration) 20. Physical Properties of X-rays 20.1. Understand the following concepts as they relate to the physical properties of x-rays: 20.1.1. Effect on photographic emulsion. 20.1.2. Fluorescence and phosphorescence 20.1.3. Inverse square law and calculations for determining new mAs factors when distance changes. 20.1.4. Interactions with matter and ionization of atoms and secondary scatter 20.1.4.1. Understand and be able to discuss photoelectric and Compton interactin, pair production, and photodisintegration and the radiation energy and physical density (subject) ranges for which these types of interactions are likely to occur. 20.1.5. Relationship of the speed of light, frequency and wavelength. Relationship of the x-ray wavelength and energy. 20.1.6. Wavelength of diagnostic x-rays compared to other forms of electromagnetic radiation (electromagnetic spectrum) 20.1.7. X-ray beam intensity and quality 20.1.8. Half value layer, linear and mass attenuation coefficients 20.2. Understand the interaction between photons and matter as related to how and when they occur, the differences between them and their role in diagnostic radiology. This includes the basic interactions related to: 20.2.1. Absorption 20.2.2. Scattering 20.2.3. Transmission 20.2.4. Mass and linear attenuation coefficient 21. Equipment and Accessories 21.1. Understand the use, limitations, advantages, disadvantages, care and construction of the following radiographic equipment: 21.1.1. Cones and collimators 21.1.2. Film 21.1.2.1. Green or blue sensitive film and specific dark room requirements 21.1.2.2. Screen versus non-screen film 21.1.2.3. Specialty film (copy film or subtraction film) 21.1.2.4. Double versus single emulsion film 21.1.2.5. H&D curves 21.1.3. Film identification devices 21.1.4. Film/screen combinations and relative film/screen speeds and contrast 21.1.5. Fluoroscopic screens Written Objectives - 2008 Last saved on: 2/15/16 Page 13 21.1.6. Grids (parallel, crossed, focused, Potter-Bucky): 21.1.6.1. Grid ratios 21.1.6.2. Grid composition 21.1.7. Cassettes and Intensifying screens 21.1.7.1. Quantum mottle, relative speed, conversion efficiency, absorption efficiency and system resolution (FWHM). 21.1.7.2. Rare earth screens 21.2. Understand the principles of the air-gap technique. 21.3. Understand the principles and mechanics of: 21.3.1. Capacitor discharge and High frequency generators 21.3.2. Fluoroscopy 21.3.3. Automatic exposure control and Image Intensifiers 21.3.4. High frequency generators 21.3.5. Magnification radiography 21.3.6. Spot film devices 22. Darkroom -- understand and be able to explain the practical application of: 22.1. Safelights 22.1.1. Purpose of safelights 22.1.2. Filter specifications for various imaging films 22.1.3. Testing and maintenance of safelight systems 22.2. Chemistry of film processing for various types of film 22.2.1. Chemical components 22.2.1.1. Developer solutions 22.2.1.2. Replenishers 22.2.1.3. Fixer solutions 22.2.1.4. Rinse baths 22.2.2. Actions of various components 22.3. Washing and drying of films after developing and fixing: 22.3.1. Purpose 22.3.2. Acceptable methods 22.4. The difference between manual and automatic processing. 22.5. The correct methods of film storage and the effects of improper film storage. 22.6. Appropriate darkroom design and construction. 22.7. Be familiar with darkroom and film processing quality control. 23. Computed/Digital Imaging 23.1. Be familiar with the use of computers and concepts of digital image formation and storage. 23.1.1. Computer hardware characteristics 23.1.1.1. Storage media 23.1.1.2. Disc drive characteristics 23.1.1.3. Units of performance and storage 23.1.2. Bits, Bytes, Pixel, Voxel, Matrix Size 23.1.3. File Types 23.1.3.1. TIFF, JPEG, DICOM (digital imaging and communication in medicine). Written Objectives - 2008 Last saved on: 2/15/16 Page 14 23.1.4. Understand the basics of PACS (Picture Archival and Communication System) and know and understand the ACVR guidelines as listed on the ACVR website 23.1.4.1. Including DICOM connectivity 23.2. Computed Radiography (CR)/Digital radiography (DR) 23.2.1. Understand the basics behind photostimulable phosphor (PSP) detection systems. 23.2.1.1. PSP plate technology and image capture. 23.2.1.2. Understand the principles behind the processing of a PSP imaging plate to the production of an image. 23.2.2. Understand the basics of Flat Panel digital radiography detection systems. 23.2.2.1. Indirect conversion detectors 23.2.2.2. Direct conversion detectors 23.2.3. Understand the difference between Thin Film Transistor (TFT) detectors and Charge Coupled Device (CCD) – based detectors 23.2.4. Understand what factors contribute to spatial resolution and overall image quality (including image noise) in CR and DR 23.2.5. Understand how digital system performance is evaluated (MTF and DQE) 23.2.6. Understand the basics of digital image processing/post-processing. 23.2.7. Be able to give the advantages and disadvantages of digital systems (CR and DR) as compared to one another and film/screen radiology. 24. Radiographic Quality and Artifacts 24.1. Understand the following characteristics of image quality and film film-screen evaluations. 24.1.1. Contrast - understand the differences between subject contrast, film contrast and radiographic contrast. 24.1.2. Density (radiographic film optical density, base optical density, film fog) 24.1.3. Detail, resolution (including full width half max measurements, FWHM) and sharpness 24.1.4. Latitude 24.1.5. Modulation transfer function 24.2. Understand the effects of the following factors on image quality 24.2.1. Geometric factors 24.2.1.1. Distortion 24.2.1.2. Magnification 24.2.1.3. Object position 24.2.1.4. Object size and shape 24.2.2. Characteristics of controllable x-ray tube factors 24.2.2.1. Focal spot size 24.2.2.2. Object-film distance 24.2.2.3. Target-film distance 24.2.2.4. Deleted 2008 24.2.3. Signal to noise ratio 25. Technique Chart Formation 25.1. Discuss the importance and relationship of the following terms as they relate to technique chart formation: 25.1.1. Focal-film distance Written Objectives - 2008 Last saved on: 2/15/16 Page 15 25.1.2. Grids 25.1.3. mA x time = mAs 25.1.4. mAs vs. kVp 25.1.5. Speed of screens and type of film 25.1.6. Subject contrast 25.1.7. Thickness of subject 25.2. Relate the following terms 25.2.1. mAs and radiographic density 25.2.2. kVp and radiographic contrast 25.2.3. kVp and radiographic density 25.3. Given a clinical case needing diagnostic radiographs, design a technique chart using factors listed in Objective 28.1 & 28.2 above. 26. General 26.1. Be familiar with the method and analysis of tests to compare various imaging systems or methods to each other in terms of diagnostic accuracy. 26.1.1. The principles of a “gold standard” 26.1.2. Be able to compute sensitivity, specificity and accuracy if provided with numerical data. Be familiar with the concepts of positive and negative predictive values. Written Objectives - 2008 Last saved on: 2/15/16 Page 16 27. SPECIAL PROCEDURES 27.General 27.1. Alternative imaging methods and diagnostic tests that may complement or supersede various special procedures in specific cases. 27.2. Knowledge of the various techniques and materials used to perform angiographic and angiocardiography procedures 27.2.1. Difference between types of catheters available, the effects of catheter configuration (i.e., length, number and position of openings) on the injection of contrast and the advantages and disadvantages of each catheter type. 27.2.2. Pigtail and Swan-Ganz catheters. 27.2.3. Moved to Physiology section) 27.2.4. Expected alterations in these values in common disease processes and congenital heart defects. 27.3. Understand the principles of fluoroscopic imaging and diagnosis including fine needle aspirate, biopsy, heartworm extraction and catheter interventional radiology. 28. Contrast media 28.1. Chemical names, relative viscosities, anionic and cationic composition of the ionic and non-ionic contrast media. 28.1.1. various combinations of methylglucamine (meglumine) and sodium diatrizoate and iothalamate, ioxaglate 28.1.2. iopamidol, iohexol, iotrolan 28.2. Advantages and disadvantages of ionic and non-ionic contrast media. 28.3. Physiologic effects, including the toxicities, of contrast media 28.4. How to manage adverse effects 28.5. Know the various physical and chemical properties of the different barium sulfate suspensions. 28.5.1. w/v and w/w formulations 29. Special Procedures - Know the indications and contra-indications, technical aspects, complications, standard imaging protocols (including positioning) and principles of interpretation for the following contrast procedures. 29.1. Gastrointestinal 29.1.1. Esophagography (including evaluation of swallowing) 29.1.2. Upper GI series 29.1.3. Gastrography (positive, negative and double contrast) 29.1.4. Colonography (positive and negative) 29.1.5. Diagnostic imaging procedures to evaluate various esophageal, gastric and intestinal transit times/function 29.1.6. Differences of various contrast media and methods for evaluation of esophageal, gastric or intestinal transit times/function 29.2. Genitourinary 29.2.1. Excretory urography 29.2.2. Cystography (positive, negative and double contrast) 29.2.3. Urethrography, vaginourethography Written Objectives - 2008 Last saved on: 2/15/16 Page 17 29.3. Nervous System 29.3.1. Myelography 29.4. Cardiovascular System 29.4.1. Angiocardiography (selective and non-selective) 29.4.2. Angiography 29.4.3. Venography (visceral and peripheral), including all methods of portography 29.4.4. Lymphangiography 29.4.5. Valvuloplasty 29.4.6. Vascular embolization techniques 29.5. Musculoskeletal 29.5.1. Arthrography 29.5.1.1. canine: shoulder 29.5.1.2. equine: shoulder, carpus, and the navicular bursa and tendon sheath 29.5.2. Fistulography 29.5.3. Stress radiography 29.6. Oculonasal 29.6.1. Dacryorhinocystography 29.7. Miscellaneous 29.7.1. Positional radiographs 29.7.2. Peritoneography 29.7.3. Deleted 2008 Written Objectives - 2008 Last saved on: 2/15/16 Page 18 30. ALTERNATE IMAGING 30.1. The examination will consist of approximately 40% ultrasonography, 20% nuclear scintigraphy, 20% computed tomography, and 20% magnetic resonance imaging. 31. Ultrasonography 31.1. Ultrasound 31.1.1. Understand the physical characteristics of the ultrasound beam 31.1.2. Understand the basic interactions of ultrasound with matter, including reflection, refraction, scattering and attenuation. 31.1.3. Know the characteristics of various transducer types (electronic versus mechanical and linear, curved, phased array, and multifrequency transducers, etc.) and the actions of a piezoelectric element. 31.1.4. Be aware of the biological effects of ultrasound. 31.1.5. Be familiar with contrast enhancing media used in ultrasound 31.1.6. Understand the factors that affect lateral and axial resolution. 31.1.7. Understand the physical factors influencing the propagation of ultrasound in tissues and the factors that influence acoustic impedance. 31.1.8. Know the relationship between wavelength, frequency, impedance and the velocity of sound in tissues. 31.1.9. Understand the properties of ultrasound beam formation and propagation particularly relative to the near field, focal zone and far field. 31.1.10. Understand the basics in calculation of reflected interfaces within tissue and the pulse echo operation (including pulse repetition frequency, pulse duration and duty factor). 31.1.11. Deleted 2008 31.1.12. Be familiar with the use of harmonic imaging, indications, contraindications and modes of action. 31.1.13. Be familiar with artifacts produced by improper equipment operation, improper scanning techniques, and those inherent in ultrasound imaging. 31.2. Methods of Image Formation and Display 31.2.1. Know the various modes of display 31.2.2. Be familiar with real-time imaging systems 31.2.3. Understand use of the controls for real-time equipment 31.3. Image Principles 31.3.1. Deleted 2008 31.4. Doppler Ultrasound 31.4.1. Understand the basics of the Doppler principle and be able to calculate the velocity of blood flow given various paramenters related to the Doppler frequency shift 31.4.2. Be familiar with transducer characteristics, instrumentation, and controls 31.4.3. Understand the difference between continuous wave, pulsed wave and color flow Doppler techniques. 31.4.4. Know the clinical application of Doppler and basic interpretation principles 31.4.5. Be able to analyze arterial wave forms using pulsatility index, resistive index and A/B ratios 31.4.6. Be familiar with Doppler energy and Color Power Doppler imaging techniques Written Objectives - 2008 Last saved on: 2/15/16 Page 19 31.5. Echocardiography 31.5.1. M-mode, 2-D and Doppler examination with recognition of normal and abnormal Doppler tracings of cardiac valves. 31.5.2. Basic cardiac anatomy from right and left parasternal window 31.5.3. Be able to calculate the pressure gradients using a modified Bernoulli equation 31.6. Clinical Application: For 2-D gray-scale ultrasonography, know the indications, selection of particular equipment, scanning protocol, normal anatomy, principles of interpretation, and appearance of disease in the following organ systems: 31.6.1. Large Animal (equine) 31.6.1.1. Musculoskeletal 31.6.1.1.1. Palmar/plantar tendons and ligaments of the metacarpus/metatarsus in transverse and longitudinal orientations 31.6.1.1.2. Removed 2008 31.6.1.2. Pleural cavity, peritoneal cavity, and diaphragm 31.6.1.3. GI, abdominal vasculature 31.6.1.4. Renal 31.6.1.5. Hepatic and splenic 31.6.1.6. Ocular 31.6.1.7. Urinary bladder 31.6.1.8. Jugular vein and surrounding anatomy. 31.6.1.9. Umbilical artery and vein and urachus (equine versus bovine differences) 31.6.1.10. Cardiac 31.6.1.11. Genital - Normal gestation, appearance of embryo/fetus in horse – evaluation with ultrasound 31.6.2. Small Animal 31.6.2.1. CNS (ventricular system, brain) 31.6.2.2. Pleural cavity, peritoneal cavity, and diaphragm 31.6.2.3. Renal /adrenal 31.6.2.4. Hepatobiliary / splenic / pancreatic 31.6.2.5. Ocular 31.6.2.6. Reproductive (ovaries, testicles, uterus, prostate) ultrasound including normal gestation, appearance of embryo/fetus in dog, cat 31.6.2.7. GI 31.6.2.8. Urinary bladder and gallbladder 31.6.2.9. Abdominal vasculature (portal vein, vena cava, aorta and branches) 31.6.2.10. Thyroid gland 31.6.2.11. Lymph nodes 31.6.2.12. Cardiac 31.6.3. Doppler ultrasonography, know the indications, selection of equipment, scanning protocol, principles of interpretation, and normal and abnormal Doppler patterns for the following: 31.6.3.1. Splanchnic vascular beds including the portal venous system, renal, hepatic, and mesenteric arteries and veins. 31.6.3.2. Heart and peripheral vascular beds 31.6.3.3. Parenchymal vascular beds of the liver, spleen and kidneys. Written Objectives - 2008 Last saved on: 2/15/16 Page 20 32. Nuclear Medicine 32.1. Nuclear medicine generator systems 32.1.1. Parent-Daughter Decay (generator systems) 32.2. Radiation Detectors 32.2.1. Scintillation Detectors - Gamma Camera 32.2.1.1. Gamma camera head including the NaI crystal, photocathode, photomultiplier tubes 32.2.1.2. Pre-Amplifier, Amplifier, and pulse height analyzer. 32.2.1.3. Rate scalers, cathode ray tube, analog digital converter (ADC) 32.2.1.4. Collimators – low energy-all purpose, diverging, converging, medium energy, pin-hole, high resolution, high sensitivity. 32.2.2. Gamma Cameras – Resolution/QC 32.2.2.1. Quality control 32.2.2.2. Factors that limit spatial and temporal resolution 32.3. Digital Image Processing 32.3.1. Types of acquisitions - frame mode, list mode, static, dynamic, gated (ECG synchronized). 32.3.2. Image depth - bit, byte and word 32.3.3. The effect of matrix size on image quality, frame rate and storage capacity 32.3.4. Types of background correction 32.3.5. Cross talk and its quantitative effect on ROI 32.3.6. Regions of interest (ROI), time activity curves and basic filtering operations including smoothing, edge detection, temporal and spatial operations. 32.4. Radiopharmaceuticals - know the indication, routes of administration, mechanisms of location and route of excretion for the following radiopharmaceuticals. Also, know the clinical scintigraphic procedures related to indications, proper radiopharmaceuticals to be used, scanning protocol, normal anatomy, common artifacts, and principles of interpretation and the appearance of disease. 32.4.1. Pertechnetate – thyroid imaging, per-rectal portal and trans-splenic scintigraphy. 32.4.2. Macroaggregated albumin (MAA) – pulmonary perfusion and right to left shunt quantification. 32.4.3. Methylene diphosphonate – three phase bone scans, pulmonary mineralization studies. 32.4.4. 99mTc-DTPA 32.4.4.1. GFR calculation 32.4.4.2. first pass radionuclide ventriculogram 32.4.4.3. left to right shunt calculation studies 32.4.4.4. radioaerosol studies 32.4.4.5. liquid phase gastric emptying studies 32.4.5. IDA – hepatobiliary scanning and calculation of hepatic extraction fraction, solid phase gastric emptying 32.4.6. MAG-3 – effective renal plasma flow. 32.4.7. HMPAO – Labeled white blood cells and cerebral perfusion imaging. 32.4.8. Cardiotec (sestamibi or MIBI) – use in myocardial and parathyroid studies 32.4.9. MIBG – adrenal scintigraphy. Written Objectives - 2008 Last saved on: 2/15/16 Page 21 99m 32.4.10. Tc-red blood cells – MUGA studies, GI bleeds 123 131 32.4.11. I, I – thyroid scintigraphy. 32.5. Analysis of Scintigraphic Procedures - Know the indications and methods of calculation of the following procedures: 32.5.1. Portosystemic shunt quantification 32.5.2. Glomerular filtration rate - imaging studies and plasma clearance 33. Computed Tomography 33.1. Computed Tomography 33.1.1. Know the principles of cross-sectional image formation including the concept of filtered back projection. 33.1.2. Know the various types of detectors and orientations used in CT scanners (“generations”) 33.1.3. Know the physical principles of helical CT scanners and the advantages and disadvantages 33.2. Image Reconstruction and Display 33.2.1. Be familiar with back-projection, iterative, and analytical methods of reconstruction 33.2.2. Understand the definition, limitations and the use of Hounsfield Units 33.2.3. Understand the definition and use of window level and window width 33.2.4. Be familiar with CT artifacts and what factors are responsible for creating them including beam hardening, and target artifacts (third generation detector). 33.2.5. Know the effect of matrix size, image depth, field of view, slice thickness, mA, and kVp on image quality 33.3. Safety 33.3.1. Be familiar with patient exposure levels during CT procedures. 33.3.2. Know important radiation safety factors for CT scanners. 33.4. Clinical Application 33.4.1. Know the indications, scanning protocol (imaging planes, desirable slice thickness, and use of contrast), normal anatomy, common artifacts, principles of interpretation and appearance of disease for regions: 33.4.1.1. Nasal cavity 33.4.1.2. Orbital region 33.4.1.3. Brain 33.4.1.4. Spine 33.4.1.5. Thorax / mediastinum 33.4.1.6. Abdomen (especially renal, adrenal, hepatic and pelvis) 33.4.1.7. Musculoskeletal system and superficial soft tissues Written Objectives - 2008 Last saved on: 2/15/16 Page 22 34. Magnetic Resonance Imaging 34.1. Basic physics 34.1.1. Know the characteristics of nuclear structure, angular momentum, magnetism and magnetic dipole moment 34.1.2. Know the basic principles and parameters associated with MRI, including the following terminology: 34.1.2.1. Larmor frequency 34.1.2.2. Magnetization vectors 34.1.2.3. Radiofrequency pulse 34.1.2.4. Free induction decay 34.1.2.5. Spin-spin relaxation time 34.1.2.6. Spin-lattice relaxation time 34.1.2.7. Pulse sequence 34.1.2.8. Chemical shift and paramagnetic substance 34.1.2.9. Contrast media and magnetic susceptibility 34.2. Basic Principles 34.2.1. Know the following terminology and the role these factors play in MR image formation: 34.2.1.1. TR, repetition time 34.2.1.2. TE, echo time 34.2.1.3. Excitation, or flip, angle 34.2.1.4. FOV 34.2.1.5. Slice thickness and slice gap 34.2.1.6. Number of averages or excitations 34.2.1.7. Slice selection, phase and frequency encoding gradients 34.3. Instrumentation 34.3.1. Know the basic principles and advantages of the different types of magnets used for MRI (permanent, resistive, superconductive). 34.3.2. Understand the basic differences between a horizontal magnet design and a vertical (open) magnet design. 34.3.3. Know the basic differences between commonly used receiver coil types (surface, quadrature, array) and their use 34.3.4. Know the function of the various components of the MRI scanner 34.3.5. Be familiar with factors that can create image artifacts, including the effect of commonly used veterinary surgical implants 34.4. Safety 34.4.1. Be familiar with safety concerns of MRI 34.5. Clinical Utility/Indications/Procedures 34.5.1. Know the general method for acquiring the following pulse sequences and their common clinical uses: 34.5.1.1. T1 pulse sequence 34.5.1.2. T2 pulse sequences (including fast spin echo T2 imaging) 34.5.1.3. Proton density pulse sequence 34.5.1.4. Gradient echo pulse sequence 34.5.2. Know the clinical utility of the following MR imaging procedures: 34.5.2.1. Fat suppression techniques (fat saturation, STIR) Written Objectives - 2008 Last saved on: 2/15/16 Page 23 34.5.2.2. MR angiography (time of flight, phase contrast) 34.5.2.3. FLAIR (fluid attenuated inversion recovery) 34.5.3. Be familiar with MRI contrast media including 34.5.3.1. Doses 34.5.3.2. Hazards 34.5.3.3. Mode of action 34.6. Clinical Applications 34.6.1. Know the indications, scanning protocol (imaging planes, desirable slice thickness, pulse sequences, use of contrast), normal anatomy, common artifacts, principles of interpretation and appearance of disease for the following studies: 34.6.1.1. Axial skeletal system including: nasal cavity, orbital region, brain and spine. 34.6.1.2. Abdomen 34.6.1.3. Musculoskeletal system and superficial soft tissues Written Objectives - 2008 Last saved on: 2/15/16 Page 24