Syllabus III
Advanced Genetic Analysis (MCB 240)
Fall, 2006 (B. J. Meyer)
http://mcb.berkeley.edu/courses/mcb240/
login name: mcb240
password: mendel
7 November
Hermaphrodite Genetics: Introduction to C. elegans
Brenner, S. (1974)
The genetics of Caenorhabditis elegans
- Genetics 77, 71-94.
This paper is the first written on C. elegans genetics, establishing the nematode as a
model genetic organism.
Reviews
Brenner, S. (2003) (Nobel Lecture)
Nature's gift to science
- ChembioChem 4, 683-687.
Fay, D. (2005)
Genetic Mapping and manipulation
- WormBook, ed. The C. elegans Research Community, WormBook,
doi/10.1895/wormbook.1.7.1, http://www.wormbook.org
Use this massive review as a reference to look up aspects of C. elegans genetics as
you need them. A quick look through will familiarize you with the contents, so
you know the topics it will clarify for you.
9 November
Building a Genetic Pathway: Cell Death
Hengartner, M., Ellis R., and Horvitz, H. R. (1992)
C. elegans gene ced-9 protects cells from programmed cell death
- Nature 356, 494-499.
Conradt, B. and Horvitz, H. R. (1998)
The C. elegans protein EGL-1 is required for programmed cell death
and interacts with the Bcl-2-like protein CED-9
- Cell 93, 519-529.
Review
Horvitz, H. R. (2003) (Nobel lecture)
Worms, Life and Death
i
- ChemBioChem 4, 697-711.
13 November
Discussion
Conradt, B. and Horvitz H. R. (1999)
The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic
cell deaths by repressing the egl-1 death activator gene
- Cell 98, 317-327.
14 November
Genetic Mosaic Analysis: Cell Signaling
Seydouz, G. and Greenwald, I. (1989)
Cell automomy of lin-12 function in a cell fate decision in C. elegans
- Cell 57, 1237-1245.
Herman, RK, Hedgecock EM 1990 Nature 348, 169-171
Review
Jochem, J. and Herman, R. K. (2003) (REVIEW)
Investigating C. elegans development through mosaic analysis
- Development 130, 4761-4768.
16 November
Convergence of Signaling Pathways to Specify Cell Fate
Chen, N. and Greenwald, I. (2004)
The lateral signal for LIN-12/Notch in C. elegans vulval development comprises
redundant secreted and transmebrane DSL proteins
- Dev. Cell 6, 183-192.
Yoo and Greenwald 2004 plus supplementary information
Sternberg 2005 wormbook
An enormous review on vulval development as a reference guide.
20 November
Discussion
Myers and Greenwald 2005
Yoo and Greenwald 2005 plus supplementary info
21 November
RNA Interference, microRNAs, Temporal Control of
Development
ii
Fire, A. et al. (1998)
Potent and specific genetic interference by double-stranded RNA in
Caenorhabditis elegans
- Nature 391, 806-811.
Reinhart, B. et al. (2000)
The 21-nucleotide let-7 RNA regulates developmental timing in C. elegans
- Nature 403, 901-906.
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