Resume
Hailin Wang, Ph D
Environmental Health Sciences,
Department of Public Health Sciences,
University of Alberta
10-110 Clinical Sciences building,
Edmonton, Alberta, Canada T6G 2G3
Email: hlwang@ualberta.ca
TEL: 1-780-492-7776
FAX: 1-780-492-7800
EDUCATION
PhD 09/1994-06/1997. Chinese Academy of Sciences, Dalian Institute of Chemical
Physics. Major in Analytical Chemistry.
MSc 09/1991-08/1994. Chinese Academy of Sciences, Dalian Institute of Chemical
Physics. Major in Analytical Chemistry.
BSc 09/1987-08/1991. Department of Chemistry, Wuhan University, Major in
Analytical Chemistry.
Work EXPERIENCE:
Postdoctoral Fellow/Research Associate, 07/2000-present. Environmental Health
Sciences Program, Department of Public Health Sciences, University of
Alberta
Associate Professor, 04/1999-07/2000. Chinese Academy of Sciences, Dalian Institute
of Chemical Physics.
Assistant Professor, 07/1997-04/1999. Chinese Academy of Sciences, Dalian Institute
of Chemical Physics.
AWARDS:
A. PRESIDENTIAL SPECIAL AWARD for graduate student by Chinese Academy
of Sciences. (10/1997).
B. Excellent Student Prize Granted by Chinese Academy of Sciences, Dalian Institute
of Chemical Physics. (07/1997).
C. CAIA (Chinese Association of Instrumental Analysis) awards for three years (1995,
1998, and 1999).
PAST RESEARCH PROJECTS:
 Novel chromatographic techniques for isolation and purification of proteins
and enzymes (membrane chromatography and monolithic chromatography).
 Studies of interactions of drug-protein and metal ion-metalloprotein using
microdialysis/HPLC.
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 Protein analysis, peptide mapping and fingerprinting analysis using HPLC, CE,
and MADLI-TOF MS.
 Enzyme microreactors.
 Immobilization of proteins, enzymes, DNA and related binding partners on
artificial membranes and silicon to develop novel biochromatographic
technique.
Screening
and analysis of biologically active components in natural products

and Chinese medicine using affinity chromatography, microdialysis/HPLC,
and MADLI-TOF MS.
CURRENT RESEARCH INTEREST
 Affinity capillary electrophoresis. Investigating DNA-Protein interaction
and antigen-antibody interaction to clarify the binding stoichiometry and the
underlined mechanisms.
 DNA damage and repair. Developing novel ultrasensitive methods and
techniques for detection of DNA damage. Techniques include capillary
electrophoresis and laser-induced fluorescence, and single cell gel
electrophoresis (comet assay).
 Assessment of human exposure to carcinogens using DNA adducts as
biomarkers. Assessment of genotoxicity of environmental carcinogens, such
as benzo(a)pyrene and arsenic, present at the levels relevant to environmental
exposure.
SELECTIVE PUBLICATIONS:
1. Le, X.C.; Pavski, V.; Wang, H. Affinity recognition, capillary electrophoresis and
laser induced fluorescence polarization for ultrasensitive bioanalysis. Submitted to
Canadian Journal of Chemistry. (Invited paper).
2. Wang, H.; Lu, M.; Mei, N.; Lee, J.; Weinfeld, M.; Le, X. C. Immunoassay using
capillary electrophoresis laser induced fluorescence detection for DNA adducts.
Analytica Chimica Acta, 500, 13-20 (2003). (Invited paper).
3. Wang, H.; Lu, M.; Weinfeld, M.; Le, X.C. Enhancement of immunocomplex
detection and application to assays for DNA adduct of benzo[a]pyrene. Analytical
Chemistry, 75, 247-254 (2003).
4. Wang, H.; Xing, J.; Tan, W.; Lam, M.; Carnelley, T.; Weinfeld, M.; Le, X.C.
Binding stoichiometry of DNA adducts with antibody studied by capillary
electrophoresis and laser-induced fluorescence. Analytical Chemistry, 74, 37143719 (2002).
5. Carnelley, T.J.; Barker, S.; Wang, H.; Tan, W.G.; Weinfeld, M.; Le, X.C. Synthesis,
characterization, and applications of a fluorescent DNA damage probe. Chemical
Research in Toxicology, 14, 1513-1522 (2001).
6. Tan, W.G.; Carnelley, T.J.; Murphy, P.; Wang, H.; Lee, J.; Barker, S.; Weinfeld, M.;
Le, X.C. Detection of DNA adducts of benzo[a]pyrene using immunoelectrophoresis with laser-induced fluorescence: analysis of A549 cells. Journal of
Chromatography A, 924, 377-386 (2001).
7. Guo, M.; Zou H.; Wang, H. Binding of metal ions with protein studied by a
combined technique of microdialysis with liquid chromatography. Analytica
Chimica Acta 443(1):91-99 (2001).
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8. Luo, Q.; Zou, H.; Wang, H. Preparation and characterization of protein A
immobilized on molded monolithic rod of macroporous poly(glycidyl
methacrylate- co-ethylene dimethacrylate) for affinity chromatography. Chinese J.
Anal. Chem. 29(5):497-501 (2001).
9. Jiang, H.; Zou, H.; Wang, H.; Ni J.; Zhang, Y. On-line characterization of the
activity and reaction kinetics of immobilized enzyme by high performance frontal
analysis. J. Chromatogr. A, 903(1-2):77-84 (2000).
10. Jiang, H.; Zou, H.; Wang, H.; Zhang, Q.; Ni, J.; Zhang, Q.-C.; Guo, Z.; Chen, X.
Combination of MALDI-TOF mass spectrometry with immobilized enzyme
microreactor for peptide mapping (I). Science in China (Series B), 30(5):385-391
(2000).
11. Jiang, H.; Zou, H.; Wang, H.; Zhang, Q.; Ni, J.; Zhang, Q.-C.; Guo, Z.; Chen, X.
Combination of MALDI-TOF mass spectrometry with immobilized enzyme
microreactor for peptide mapping (II). Science in China (Series B), 43(6):625-633
(2000).
12. Zhang, Q.; Zou, H.; Wang, H.; Ni, J. Synthesis of a silica-bonded BSA s-triazine
chiral stationary for high-performance liquid chromatographic resolution of
enantiomers. J. Chromatogr. A, 866:173~181 (2000).
13. Wang, H.; Kong, L.; Zou, H.; Ni, J.; Zhang, Y. Screening and analysis of
biologically active compounds in angelica sinensis by molecular
biochromatography. Chromatographia, 50:439 (1999).
14. Wang, H.; Zou, H.; Zhang, Y. Determination of ginsengoside Rg3 in plasma by
solid phase extraction and high performance liquid chromatography for
pharmacokinetic study. J. Chromatogr. B, 731:403 (1999).
15. Zou, H.; Wang, H.; Zhang, Y. Drug-protein interaction studied by technique of
microdialysis combined with high performance liquid chromatography. Rewiews
in Anal. Chem., 18:383 (1999) (Invited review).
16. Wang, H.; Zou, H.; Zhang, Y. Quantitative study of competitive binding of drugs
to protein by microdialysis / high-performance liquid chromatography. Analytical
Chemistry, 70(2):373-377 (1998). Reprint: HTML/PDF
18. Wang, H.; Zou; H.; Feng; A.; Zhang; Y. Binding of sulfamethoxazole to human
serum albumin by a combined technique of microdialysis with high performance
liquid chromatography. Analytica Chimica Acta, 342:159-165 (1997).
19. Wang, H.; Feng A.; Zou H.; Lee R.; Zhang J.; Chao R.; Zhang Y. Determination
of bile Acids in human serum by high performance liquid chromatography with
fluorescence Detection. Chinese J. Instr. Analysis, 16(5):18 (1997).
20. Wang, H.; Li, T.; Zou, H.; Zhang, Y.; Chao, J.; Chao, L. The purification of
human urinary kallikrein with ion-exchange radial flow membrane chromatography.
Biomed. Chromatogr., 10: 139 (1996).
21. Zou, H.; Wang, H.; Lee, R.; Zhang, Y. Separation mechanism of micellarelectrokinetic capillary chromatography studied by quantitive-structure
retentionship. Progress in Nature Science (Chinese), 6: 683 (1996).
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