Registry of Toxic Effects of Chemical Substances - N

NADP (BETA-)

RTECS NUMBER : UU3440000

CHEMICAL NAME : Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-,

hydroxide, 5',5'-ester with adenosine 2'-

(dihydrogen

phosphate) 5'-(trihydrogen pyrophosphate), inner salt

CAS REGISTRY NUMBER : 53-59-8

BEILSTEIN REFERENCE NO. : 3885115

REFERENCE : 4-26-00-03672 (Beilstein Handbook Reference)

LAST UPDATED : 199709

DATA ITEMS CITED : 4

MOLECULAR FORMULA : C21-H28-N7-O17-P3

MOLECULAR WEIGHT : 743.47

COMPOUND DESCRIPTOR : Drug

SYNONYMS/TRADE NAMES :

* Codehydrase II

* Codehydrogenase II

* Coenzyme II

* Cozymase II

* NADP

* beta-NADP

* NAD phosphate

* TPN

* beta-TPN

* TPN (nucleotide)

* Triphosphopyridine nucleotide

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intraperitoneal

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 3166 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PCJOAU Pharmaceutical Chemistry Journal (English Translation).

Translation

of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-

1967- Volume(issue)/page/year: 20,160,1986

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - A1187

No. of Facilities: 58 (estimated)

No. of Industries: 2

No. of Occupations: 2

No. of Employees: 332 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - A1187





No. of Female Employees: 3928 (estimated)

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

NALIDIXIC ACID

RTECS NUMBER : QN2885000

CHEMICAL NAME : 1,8-Naphthyridine-3-carboxylic acid,

1-ethyl-1,4-dihydro-7-methyl-4-oxo-






MOLECULAR FORMULA : C12-H12-N2-O3


WISWESSER LINE NOTATION : T66 BN EV JNJ B2 DVQ I1

COMPOUND DESCRIPTOR : Tumorigen

Drug

Mutagen

Reproductive Effector

Human


* Acide 1-etil-7-metil-1,8-naftiridin-4-one-3-carbossilico

* Acide nalidixico

* Acide nalidixique

* 1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure

* Betaxina

* 3-Carboxy-1-ethyl-7-methyl-1,8-naphthidin-4-one

* Cybis

* 1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

* Dixiben

* 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxilic acid

* 1-Ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid

* 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

* Eucisten

* Innoxalon

* Kusnarin

* Nalidic acid

* Nalidicron

* Nalidixan

* Nalidixic acid

* Nalidixin

* Nalidixinic acid

* Nalitucsan

* Nalix

* Nalurin

* Narigix

* Naxuril

* NCI-C56199

* Neggram

* Nevigramon

* Nicelate

* Nogram

* NSC-82174

* Poleon

* Specifen

* Uralgin

* Uriben

* Uriclar

* Urisal

* Urodixin

* Uroman

* Uroneg

* Uropan

* WIN 18,320

* Wintomylon



TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Human - woman


TOXIC EFFECTS :

Brain and Coverings - increased intracranial pressure

Behavioral - coma

REFERENCE :

AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430

Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:

216,237,1984




DOSE/DURATION : 160 mg/kg/2D

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

Endocrine - hyperglycemia

Skin and Appendages - sweating

REFERENCE :

BMJOAE British Medical Journal. (British Medical Assoc., BMA House,

Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-

Volume(issue)/page/year:

2,1518,1977





TOXIC EFFECTS :

Behavioral - coma

Cardiac - EKG changes not diagnostic of specified effects

Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :

ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service

Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-

Volume(issue)/page/year: 5,141,1979


ROUTE OF EXPOSURE : Unreported

SPECIES OBSERVED : Human - child


TOXIC EFFECTS :

Blood - other changes

REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,

Academic Press, Inc., 1969 Volume(issue)/page/year: -,414,1969



SPECIES OBSERVED : Rodent - rat


TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)


Skin and Appendages - hair

REFERENCE :

NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8

Kamiosaki,

Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:

28(Suppl 4),406,1980





TOXIC EFFECTS :


REFERENCE :

AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)

1961-70. For publisher information, see AMACCQ.


-,117,1970


ROUTE OF EXPOSURE : Subcutaneous



TOXIC EFFECTS :


REFERENCE :




-,117,1970


ROUTE OF EXPOSURE : Intravenous



TOXIC EFFECTS :


REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: -,908,1995





TOXIC EFFECTS :


REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

18,185,1971





TOXIC EFFECTS :


REFERENCE :

USXXAM United States Patent Document. (U.S. Patent Office, Box 9,

Washington, DC 20231) Volume(issue)/page/year: #4552882





TOXIC EFFECTS :


REFERENCE :



18,185,1971





TOXIC EFFECTS :


REFERENCE :




-,117,1970

** OTHER MULTIPLE DOSE TOXICITY DATA **




DOSE/DURATION : 44800 mg/kg/4W-I

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

Related to Chronic Data - death

REFERENCE :




-,117,1970




DOSE/DURATION : 24 gm/kg/30D-C

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - other changes


REFERENCE :


Kamiosaki,


19,404,1971




DOSE/DURATION : 21840 mg/kg/13W-C

TOXIC EFFECTS :



REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-368,1989





TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood - changes in leukocyte (WBC) count

REFERENCE :


Kamiosaki,


19,404,1971





TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - retinal changes (pigmentary

depositions, retinitis, other)

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,

Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-






TOXIC EFFECTS :



REFERENCE :



NTP-TR-368,1989



SPECIES OBSERVED : Mammal - dog

DOSE/DURATION : 400 mg/kg/2D-I

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting

REFERENCE :




-,117,1970

** TUMORIGENIC DATA **




DOSE/DURATION : 173 gm/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria

Skin and Appendages - tumors

Reproductive - Tumorigenic effects - other reproductive system tumors

REFERENCE :



NTP-TR-368,1989





TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Lungs, Thorax, or Respiration - tumors


REFERENCE :



NTP-TR-368,1989

** REPRODUCTIVE DATA **




DOSE : 1320 mg/kg

SEX/DURATION : female 9-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :


Kamiosaki,


19,422,1971




DOSE : 3300 mg/kg


TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured

before birth)

Reproductive - Effects on Embryo or Fetus - extra-embryonic structures

(e.g., placenta, umbilical cord)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :


Kamiosaki,


28(Suppl 4),484,1980




DOSE : 3300 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death


Reproductive - Effects on Newborn - stillbirth

REFERENCE :


Kamiosaki,


28(Suppl 4),484,1980




DOSE : 3300 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after birth)

Reproductive - Effects on Newborn - viability index (e.g., # alive at day

4

per # born alive)

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight

gain)

REFERENCE :


Kamiosaki,


28(Suppl 4),484,1980




DOSE : 3960 mg/kg


TOXIC EFFECTS :




REFERENCE :


Kamiosaki,


19,422,1971



SPECIES OBSERVED : Rodent - rabbit

DOSE : 10400 mg/kg


TOXIC EFFECTS :


before birth)


REFERENCE :


Kamiosaki,


28(Suppl 4),508,1980

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium

DOSE/DURATION : 8 mg/L

REFERENCE :

AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for

Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-



TEST SYSTEM : Bacteria - Escherichia coli


REFERENCE :

KEKHB8 Kanagawa-ken Eisei Kenkyusho Kenkyu Hokoku. Bulletin of Kanagawa

Prefectural Public Health Laboratories. (Kanagawa-ken Eisei Kenkyusho,

52-2, Nakao-cho, Asahi-ku, Yokohama 241, Japan) No.1- 1971-

Volume(issue)/page/year: (8),47,1978

TYPE OF TEST : Mutation test systems - not otherwise specified



REFERENCE :




TYPE OF TEST : DNA repair


DOSE/DURATION : 6 ug/disc

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982

TYPE OF TEST : DNA damage



REFERENCE :

PNASA6 Proceedings of the National Academy of Sciences of the United

States

of America. (National Academy of Sciences, Printing & Pub. Office, 2101

Constitution Ave., Washington, DC 20418) V.1- 1915-


TYPE OF TEST : DNA inhibition


DOSE/DURATION : 2300 ug/L

REFERENCE :







REFERENCE :

EJBCAI European Journal of Biochemistry. (Springer-Verlag New York,

Inc.,

Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967-


TYPE OF TEST : Phage inhibition capacity



REFERENCE :

VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN

55802)

V.1- 1955- Volume(issue)/page/year: 41,244,1970


TEST SYSTEM : Bacteria - Bacillus subtilis


REFERENCE :


Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

95,191,1982




REFERENCE :




TEST SYSTEM : Bacteria - Serratia marcescens


REFERENCE :





TEST SYSTEM : Microorganism - not otherwise specified


REFERENCE :



74,113,1980




REFERENCE :



25,25,1974




REFERENCE :

JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First

St.,

Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 75,99,1973




REFERENCE :

JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I

St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year:

116,1398,1973




REFERENCE :

JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St.,

NW, Washington, DC 20006) V.1- 1967- Volume(issue)/page/year:

24,716,1977




REFERENCE :

MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger

Pl.

3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-





REFERENCE :







REFERENCE :






DOSE/DURATION : 30 ug/plate

REFERENCE :

ZMMPAO Zentralblatt fuer Bakteriologie, Parasitenkunde,

Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A:

Medizinische Mikrobiologie und Parasitologie. (Stuttgart, Fed. Rep.

Ger.)

V.217-245, 1971-79. Volume(issue)/page/year: 231,369,1975

TYPE OF TEST : Sex chromosome loss and nondisjunction


TEST SYSTEM : Insect - Drosophila melanogaster

DOSE/DURATION : 20 mg/3D

REFERENCE :

SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub.

Corp.,

233 Spring St., New York, NY 10013) V.2- 1966-


10,128,1974


TEST SYSTEM : Yeast - Saccharomyces cerevisiae


REFERENCE :







REFERENCE :




TYPE OF TEST : Unscheduled DNA synthesis

TEST SYSTEM : Yeast - Schizosaccharomyces pombe


REFERENCE :


Pl.




TEST SYSTEM : Yeast - Schizosaccharomyces pombe


REFERENCE :


Pl.




TEST SYSTEM : Protozoa - Chlamydomonas reinhardi


REFERENCE :

COINAV Colloques Internationaux du Centre National de la Recherche

Scientifique. (Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA

02018) V.1- 1946- Volume(issue)/page/year: 240,167,1975


TEST SYSTEM : Protozoa - Euglena gracilis


REFERENCE :

ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1

E.


165,548,1974




REFERENCE :


E.


165,548,1974




REFERENCE :


E.


165,548,1974


TEST SYSTEM : Human Cells - not otherwise specified


REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

46,2929,1986

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Human Lymphocyte

DOSE/DURATION : 25 umol/L

REFERENCE :



368,205,1996


TEST SYSTEM : Rodent - mouse Cells - not otherwise specified

DOSE/DURATION : 10 mmol/L

REFERENCE :

BBRCA9 Biochemical and Biophysical Research Communications. (Academic

Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-



TEST SYSTEM : Rodent - hamster Lung


REFERENCE :



243,213,1990


TEST SYSTEM : Rodent - hamster Ovary


REFERENCE :

CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44

Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:

85,603,1982


TEST SYSTEM : Mammal - domestic Cells - not otherwise specified


REFERENCE :







NOES Hazard Code - X3708







EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA

without S9

EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

NTP Carcinogenesis Studies (feed);clear evidence:rat



NTP-TR-368,1989

NTP Carcinogenesis Studies (feed);equivocal evidence:mouse



NTP-TR-368,1989

NALIDIXIC ACID SODIUM


CHEMICAL NAME : 1,8-Naphthyridine-3-carboxylic acid,

1-ethyl-1,4-dihydro-7-methyl-4-oxo-, sodium salt




MOLECULAR FORMULA : C12-H12-N2-O3.Na


COMPOUND DESCRIPTOR : Mutagen


* 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

sodium salt

* Nalidixate sodium

* Nalidixic acid sodium salt

* Sodium nalidixate

* Sodium nilixalate

* WIN 18320-3


** MUTATION DATA **


TEST SYSTEM : Rodent - rat Cells - not otherwise specified


REFERENCE :

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,

D-1000

Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:

60,287,1987

NAPHTHA

RTECS NUMBER : OI6180000

CHEMICAL NAME : Ligroine


OTHER CAS REGISTRY NOS. : 8031-06-9



COMPOUND DESCRIPTOR : Reproductive Effector

Primary Irritant


* Benzine (light petroleum distillate)

* Benzoline

* Canadol

* Ligroin

* Painters naphtha

* Petroleum ether

* Refined solvent naphtha

* Skellysolve F

* Skellysolve G

* Varnish marker's naphtha

* VM and P Naphtha

* VM & P Naphtha


** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration into the eye

SPECIES OBSERVED : Human

DOSE/DURATION : 880 ppm/15M

REFERENCE :



32,263,1975


TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE : Inhalation


DOSE/DURATION : 3400 ppm/4H

TOXIC EFFECTS :


Behavioral - muscle weakness

REFERENCE :



32,263,1975

TYPE OF TEST : LCLo - Lowest published lethal concentration



DOSE/DURATION : 153 gm/m3/31M

TOXIC EFFECTS :


Behavioral - changes in motor activity (specific assay)

REFERENCE :

BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For

publisher information, see EJBCAI. Volume(issue)/page/year: 115,235,1921





TOXIC EFFECTS :


REFERENCE :


Translation




TYPE OF TEST : TCLo - Lowest published toxic concentration



DOSE : 300 mg/m3/4H


TOXIC EFFECTS :


Reproductive - Effects on Newborn - behavioral

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-

Volume(issue)/page/year: 56(9),35,1991

*** REVIEWS ***

ACGIH TLV-Animal carcinogen

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

ACGIH TLV-TWA 1370 mg/m3 (300 ppm)




TLV/BEI,1997

*** U.S. STANDARDS AND REGULATIONS ***

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of

Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:

54,7740,1989

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-POLAND: TWA 500 mg/m3, STEL 1500 mg/m3, JAN1999


NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :

NIOSH REL TO VM & P NAPHTHA-air:10H TWA 350 mg/m3;CL 1800 mg/m3/15M

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of

Health, Education, and Welfare, Reports and Memoranda.

Volume(issue)/page/year: DHHS #92-100,1992



NOHS Hazard Code - M0630












NOHS Hazard Code - T0180






NOES Hazard Code - M0630







NOES Hazard Code - T0180








EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

NIOSH Analytical Method, 1994: Naphthas, 1550

NAPHTHALDEHYDE (1-)

RTECS NUMBER : QJ0190000

CHEMICAL NAME : 1-Naphthaldehyde






MOLECULAR FORMULA : C11-H8-O


WISWESSER LINE NOTATION : L66J BVH



* 1-Formylnaphthalene

* alpha-Naphthal

* alpha-Naphthaldehyde

* 1-Naphthalenecarboxaldehyde

* alpha-Naphthylaldehyde

* 1-Naphthylaldehyde

* alpha-Naphthylcarboxaldehyde







TOXIC EFFECTS :




REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: OTS0533568





TOXIC EFFECTS :


REFERENCE :

FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,

Italy) V.8-43 1953-88 For publisher information, see FRMCE8



ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - guinea pig

DOSE/DURATION : >20 mL/kg

TOXIC EFFECTS :

Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :
















NAPHTHALDEHYDE (2-)


CHEMICAL NAME : 2-Naphthaldehyde








WISWESSER LINE NOTATION : L66J CVH



* beta-Formylnaphthalene

* 2-Formylnaphthalene

* beta-Naphthaldehyde

* 2-Naphthalenecarboxaldehyde

* beta-Naphthylaldehyde

* beta-Naphthylcarboxaldehyde







TOXIC EFFECTS :


REFERENCE :




NAPHTHALENE


CHEMICAL NAME : Naphthalene




MOLECULAR FORMULA : C10-H8


WISWESSER LINE NOTATION : L66J

COMPOUND DESCRIPTOR : Agricultural Chemical

Tumorigen

Mutagen


Human

Primary Irritant


* Albocarbon

* Camphor tar

* Mighty 150

* Mighty RD1

* Moth balls

* Moth flakes

* Naftalen

* Naphthalene

* Naphthalin

* Naphthaline

* Naphthene

* NCI-C52904

* RCRA waste number U165

* Tar camphor

* White tar



TYPE OF TEST : Open irritation test



DOSE/DURATION : 495 mg

REACTION SEVERITY : Mild

REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/11/1968






REFERENCE :

BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810

Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 16-4/1970


TYPE OF TEST : LDLo - Lowest published lethal dose




TOXIC EFFECTS :


REFERENCE :

28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde,

H.,

New York, Elsevier, 1960 Volume(issue)/page/year: -,228,1960





TOXIC EFFECTS :


REFERENCE :

YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,

Tokyo,

Japan) V.1- 1950- Volume(issue)/page/year: 31,1499,1980



SPECIES OBSERVED : Human - man


TOXIC EFFECTS :


REFERENCE :

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,

J.M.,

Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970





TOXIC EFFECTS :


REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under

Single

Exposure," Izmerov, N.F., et al., Moscow, Centre of International

Projects,

GKNT, 1982 Volume(issue)/page/year: -,89,1982




DOSE/DURATION : >340 mg/m3/1H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation


REFERENCE :






DOSE/DURATION : >2500 mg/kg

TOXIC EFFECTS :


REFERENCE :



14,515,1969





TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis

Behavioral - ataxia

Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,

see TOSCF2 Volume(issue)/page/year: 4,406,1984





TOXIC EFFECTS :


REFERENCE :



Volume(issue)/page/year: AD691-490





TOXIC EFFECTS :

Behavioral - tremor

REFERENCE :

TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho

University.

(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,






TOXIC EFFECTS :


REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical

Systems

Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD

21010)

Volume(issue)/page/year: NX#00203





TOXIC EFFECTS :


REFERENCE :

HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."

(Leipzig,

Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935



SPECIES OBSERVED : Mammal - cat

DOSE/DURATION : 1 gm/kg

TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :


(Leipzig,





DOSE/DURATION : >20 gm/kg

TOXIC EFFECTS :


REFERENCE :



Volume(issue)/page/year: AD-A062-138





TOXIC EFFECTS :



REFERENCE :








DOSE/DURATION : 10 gm/kg/10D-I

TOXIC EFFECTS :

Liver - other changes


Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE


8,311,1981




DOSE/DURATION : 1680 mg/kg/28D-C

TOXIC EFFECTS :

Endocrine - changes in adrenal weight

REFERENCE :







TOXIC EFFECTS :



Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - other oxidoreductases

REFERENCE :


D-1000


61,480,1988





TOXIC EFFECTS :

Blood - changes in spleen


REFERENCE :








TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


Blood - lymphoma, including Hodgkin's disease

Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :

APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und

fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher

information, see VAAPB7. Volume(issue)/page/year: 329,141,1956




DOSE/DURATION : 30 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria


REFERENCE :



NTP-TR-410,1992





DOSE : 4500 mg/kg


TOXIC EFFECTS :



Reproductive - Specific Developmental Abnormalities - other developmental

abnormalities

REFERENCE :



Volume(issue)/page/year: PB92-135623




DOSE : 5925 mg/kg


TOXIC EFFECTS :


Reproductive - Specific Developmental Abnormalities - cardiovascular

(circulatory) system

REFERENCE :



48,A35,1979




DOSE : 2400 mg/kg


TOXIC EFFECTS :



4

per # born alive)

REFERENCE :

JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,

1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-


** MUTATION DATA **

TYPE OF TEST : Specific locus test




REFERENCE :



341,235,1995

TYPE OF TEST : Micronucleus test



REFERENCE :



393,23,1997

TYPE OF TEST : Cytogenetic analysis



REFERENCE :



NTP-TR-410,1992




REFERENCE :



NTP-TR-410,1992

*** REVIEWS ***

ACGIH TLV-Not classifiable as a human carcinogen




TLV/BEI,1997

ACGIH TLV-STEL 79 mg/m3 (15 ppm)




TLV/BEI,1997





TLV/BEI,1997

TOXICOLOGY REVIEW

CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000

Corporate

Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:

1(1),93,1971

TOXICOLOGY REVIEW

JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial

Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year:

59,1,1961





54,7740,1989

MSHA STANDARD-air:TWA 10 ppm (50 mg/m3)




3,177,1971

OSHA PEL (Gen Indu):8H TWA 10 ppm (50 mg/m3)

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

29,1910.1000,1994

OSHA PEL (Construc):8H TWA 10 ppm (50 mg/m3)


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 10 ppm (50 mg/m3)


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 10 ppm (50 mg/m3)


Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 10 ppm (50 mg/m3) JAN 1993

OEL-AUSTRIA: MAK 10 ppm (50 mg/m3), JAN1999

OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);STEL 15 ppm (75 mg/m3) JAN 1993

OEL-BELGIUM:TWA 10 ppm (52 mg/m3);STEL 15 ppm (79 mg/m3) JAN 1993

OEL-DENMARK: TWA 10 ppm (50 mg/m3), JAN1999

OEL-FINLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm (100 mg/m3) JAN 1993

OEL-GERMANY:TWA 10 ppm (50 mg/m3) JAN 1993

OEL-HUNGARY:TWA 40 mg/m3;STEL 80 mg/m3;Skin JAN 1993

OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3) JAN 1993

OEL-POLAND: MAC(TWA) 20 mg/m3, MAC(STEL) 75 mg/m3, JAN1999

OEL-THE PHILIPPINES:TWA 10 ppm (50 mg/m3) JAN 1993

OEL-RUSSIA:STEL 20 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3) JAN 1993

OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);STEL 15 ppm (75 mg/m3) JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV



NIOSH REL TO NAPHTHALENE-air:10H TWA 10 ppm;STEL 15 ppm

REFERENCE :






NOHS Hazard Code - 49600






NOES Hazard Code - 49600







EPA GENETOX PROGRAM 1988, Negative: Cell transform.-mouse embryo

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test



On EPA IRIS database


NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501

NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,

5506; by GC, 5515

NTP Carcinogenesis Studies (inhalation);some evidence:mouse



NTP-TR-410,1992

NTP Carcinogenesis studies; on test (two year studies), May 1999

OSHA ANALYTICAL METHOD #35

NAPHTHALENEACETAMIDE (ALPHA-)


CHEMICAL NAME : 1-Naphthaleneacetamide






MOLECULAR FORMULA : C12-H11-N-O


WISWESSER LINE NOTATION : L66J B1VZ



* Amid kyseliny 1-naftyloctove

* Amid-Thin

* Amid-Thin W

* Dirigol N

* Frufix

* alpha-NAA amide

* NAAm

* Naphthalene acetamide

* alpha-Naphthaleneacetamide

* alpha-Naphthylacetamide

* 1-Naphthylacetamide

* 2-(1-Naphthyl)acetamide

* Rootone







TOXIC EFFECTS :


REFERENCE :

FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,

Willoughy, OH 44094) Volume(issue)/page/year: -,C214,1991





TOXIC EFFECTS :


REFERENCE :

PEMNDP Pesticide Manual. (The British Crop Protection Council, 20

Bridport

Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:

9,606,1991





54,7740,1989












NAPHTHAQUINONE (1,2-)

RTECS NUMBER : QL7000000

CHEMICAL NAME : 1,2-Naphthoquinone






MOLECULAR FORMULA : C10-H6-O2


WISWESSER LINE NOTATION : L66 BVVJ



* 1,2-Naftochinon

* 1,2-Naphthalenedione

* 1,2-Naphthaquinone

* beta-Naphthoquinone







TOXIC EFFECTS :


REFERENCE :

NCNSA6 National Academy of Sciences, National Research Council,

Chemical-Biological Coordination Center, Review. (Washington, DC)






TOXIC EFFECTS :


REFERENCE :

AECTCV Archives of Environmental Contamination and Toxicology.

(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,

NJ




SPECIES OBSERVED : Bird - wild bird species


TOXIC EFFECTS :


REFERENCE :



NJ




NAPHTHIONIC ACID (1,4-)

RTECS NUMBER : QK1270000

CHEMICAL NAME : 1-Naphthalenesulfonic acid, 4-amino-




MOLECULAR FORMULA : C10-H9-N-O3-S


WISWESSER LINE NOTATION : L66J BZ ESWQ



* 1-Aminonaphthalene-4-sulfonic acid

* 4-Amino-1-naphthalenesulfonic acid

* 1-Amino-4-sulfonaphthalene

* Kyselina nafthionova

* Kyselina 1-naftylamin-4-sulfonova

* Naphthionic acid

* 1,4-Naphthionic acid

* alpha-Naphthylamine-p-sulfonic acid

* 1-Naphthylamine-4-sulfonic acid

* Piria's acid

* USAF M-5



TYPE OF TEST : LD - Lethal dose




TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :





EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test




NAPHTHOHYDROQUINONE (ALPHA,PARA-)


CHEMICAL NAME : 1,4-Naphthalenediol








WISWESSER LINE NOTATION : L66J BQ EQ


Mutagen


* 1,4-Dihydroxynaphthalene

* Hydronaphthoquinone

* Naphthohydroquinone

* 1,4-Naphthohydroquinone

* alpha-Naphthoquinhydrone

* 1,4-Naphthoquinol







TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **



DOSE/DURATION : 5 nmol/plate

REFERENCE :



371,293,1996












NAPHTHOIC ACID (1-)


CHEMICAL NAME : 1-Naphthoic acid







* 1-Carboxynaphthalene

* Naphthalene-alpha-carboxylic acid

* 1-Naphthalenecarboxylic acid

* alpha-Naphthoic acid

* alpha-Naphthylcarboxylic acid







TOXIC EFFECTS :


REFERENCE :






NAPHTHOIC ACID (2-)


CHEMICAL NAME : 2-Naphthoic acid








WISWESSER LINE NOTATION : L66J CVQ


* 2-Carboxynaphthalene

* Isonaphthoic acid

* 2-Maythic acid

* Naphthalene-beta-carboxylic acid

* 2-Naphthalenecarboxylic acid

* beta-Naphthoic acid







TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex)


REFERENCE :

CBCCT* "Summary Tables of Biological Tests," National Research Council

Chemical-Biological Coordination Center. (National Academy of Science

Library, 2101 Constitution Ave., NW, Washington, DC 20418)



OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993



NAPHTHOL (1-)


CHEMICAL NAME : 1-Naphthol






WISWESSER LINE NOTATION : L66J BQ



Primary Irritant


* Basf Ursol ERN

* C.I. 76605

* C.I. Oxidation Base 33

* Durafur developer D

* Fouramine ERN

* Fourrine 99

* Fourrine ERN

* Furro ER

* alpha-Hydroxynaphthalene

* 1-Hydroxynaphthalene

* Nako TRB

* 1-Naphthalenol

* alpha-Naphthol

* Tertral ERN

* Ursol ERN

* Zoba ERN






DOSE/DURATION : 500 mg/24H

REACTION SEVERITY : Severe

REFERENCE :







REACTION SEVERITY : Moderate

REFERENCE :








REFERENCE :








TOXIC EFFECTS :


REFERENCE :

TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection

Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Volume(issue)/page/year: FYI-OTS-0885-0443





TOXIC EFFECTS :


Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :







TOXIC EFFECTS :


REFERENCE :

TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection

Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Volume(issue)/page/year: FYI-OTS-0885-0443





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf

Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:

23,95,1962





TOXIC EFFECTS :


REFERENCE :


Tokyo,






TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


Kidney, Ureter, Bladder - urine volume increased

REFERENCE :






DOSE/DURATION : 2 gm/kg/2W-I

TOXIC EFFECTS :



REFERENCE :








DOSE : 90 mg/kg


TOXIC EFFECTS :


before birth)



REFERENCE :




** MUTATION DATA **




REFERENCE :

BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,

Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-


37,873,1978



DOSE/DURATION : 2 mg/disc

REFERENCE :





DOSE/DURATION : 5 gm/L

REFERENCE :



42,19,1977

*** REVIEWS ***

TOXICOLOGY REVIEW



47,75,1978



















EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine

reversion-Ames test

EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus




NAPHTHOL (2-)


CHEMICAL NAME : 2-Naphthol






WISWESSER LINE NOTATION : L66J CQ


Mutagen

Primary Irritant


* Azogen developer A

* C.I. 37500

* C.I. Azoic Coupling Component 1

* C.I. Developer 5

* Developer A

* Developer AMS

* Developer BN

* Developer sodium

* beta-Hydroxynaphthalene

* 2-Hydroxynaphthalene

* Isonaphthol

* beta-Monoxynaphthalene

* beta-Naftol

* 2-Naftol

* beta-Naftolo

* 2-Naftolo

* 2-Naphthalenol

* Naphthol B

* beta-Naphthol

* 2-Naphtol

* beta-Naphthyl alcohol

* beta-Naphthyl hydroxide

* beta-Naphtol








REFERENCE :








REFERENCE :








TOXIC EFFECTS :


REFERENCE :

GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR.

Labor

Hygiene and Occupational Pathology in the Estonian SSR. (Institut

Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya

Estonskoi SSR, Tallinn, USSR) V.8- 1972- Volume(issue)/page/year:

8,145,1972





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :

Behavioral - sleep



REFERENCE :

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und

Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher

information, see NSAPCC. Volume(issue)/page/year: 186,195,1937





TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :

EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.

(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)






TOXIC EFFECTS :


REFERENCE :

ZHINAV Zeitschrift fuer Hygiene und Infektionskrankheiten. (Berlin, Fed.

Rep. Ger.) V.11-151, 1892-1965. For publisher information, see MMIYAO.






TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :


Tokyo,






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :


Tokyo,






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :



REFERENCE :









TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in bladder weight


REFERENCE :







TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

Behavioral - alteration of classical conditioning

REFERENCE :







DOSE/DURATION : 1350 ug/m3/17W-I

TOXIC EFFECTS :

Blood - changes in erythrocyte (RBC) count



levels - other esterases

REFERENCE :








TOXIC EFFECTS :

Liver - liver function tests impaired

REFERENCE :




** MUTATION DATA **




REFERENCE :






REFERENCE :



42,19,1977

*** REVIEWS ***

TOXICOLOGY REVIEW



47,75,1978





54,7740,1989




























NAPHTHOL AS


CHEMICAL NAME : 2-Naphthalenecarboxamide, 3-hydroxy-N-phenyl-




MOLECULAR FORMULA : C17-H13-N-O2



* ACCO Naphthol AS

* ACNA Naphthol C

* Amanil Naphthol AS

* Amarthol AS

* Anthonaphthol AS

* Aquafine Red E 9

* Azoground AS

* Azonaphthol A

* Azotol A

* Brenthol AS

* Celcot RF

* Cibanaphthol RF

* C.I. 37505

* C.I. Azoic Coupling Component 2

* Diathol AS

* Diathol ASF

* Dragonthol A

* Hiltonphthol AS

* 3-Hydroxy-N-phenyl-2-naphthalenecarboxamide

* 2-Hydroxy-3-naphthoic acid anilide

* Kambothol AS

* Lake Developer A

* Mitsui Naphthozol AS

* Naftolo MM

* Naphthanilide OL Supra

* Naphthanilide RC

* Naphthanilide RC Supra

* Naphtazol A

* Naphthanil AS

* 2-Naphthanilide, 3-hydroxy-

* Naphthoide AS

* Naphthoide AS No. 100

* Naphthol ACNAC

* Naphthol AS

* Naphthol AS-A

* Naphthol AS Supra

* Naphtholate AS

* Naphtoelan A

* Naphtol AS

* Solunaptol A

* Tulathol AS

* Ultrazol I-AS







TOXIC EFFECTS :


REFERENCE :

ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic

Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,

Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:

104,51,1986






TOXIC EFFECTS :



levels - transaminases

REFERENCE :




104,51,1986



NAPHTHOL BLUE BLACK


CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,

4-amino-5-hydroxy-3-((4-nitrophenyl)azo)-6-(phenylazo

)-, disodium salt





MOLECULAR FORMULA : C22-H16-N6-O9-S2.2Na




* Acidal Black 10B

* Acidal Navy Blue 3BR

* Acid Black 10A

* Acid Black 10B

* Acid Black 12B

* Acid Black 10BA

* Acid Black Base M

* Acid Black 4BN

* Acid Black 4BNU

* Acid Black 10BN

* Acid Black BRX

* Acid Black BX

* Acid Black H

* Acid Black 1

* Acid Black JVS

* Acid Blue Black B

* Acid Blue Black 10B

* Acid Blue Black BG

* Acid Blue Black Double 600

* Acid Leather Blue IGW

* Acid Leather Dark Blue G

* Acid Leather Fast Blue Black G

* Airedale Black 2BG

* Amacid Black 10BR

* Atul Acid Black 10BX

* Atul Acid Black BX

* Azanol Fast Acid Black 10B

* Azo Dark Blue C 2B

* Azo Dark Blue HR

* Azo Dark Blue S

* Azo Dark Blue SH

* Blue Black 12B

* Blue Black SX

* Boruta Black A

* Brasilan Black BS

* Bucacid Blue Black

* Calcocid Blue Black

* Calcocid Blue Black 2R

* CERN kysela 1

* C.I. 20470

* C.I. Acid Black 1

* C.I. Acid Black 1, disodium salt

* Colacid Black 10A

* Comacid Blue Black B

* Diacid Blue Black 10B

* Eniacid Black IVS

* Eniacid Black SH

* Eriosin Blue Black B

* Fast Sulon Black BN

* Fenazo Blue Black


** MUTATION DATA **




REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41

E.

11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:

22,188,1993

















EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay


NAPHTHOL GREEN B

RTECS NUMBER : LJ8930000

CHEMICAL NAME : Ferrate(3-), tris(5,6-dihydro-5-(hydroxyimino)-6-oxo-2-naphthalene

sulfonato(2-)-N(sup 5), O(sup 6))-, trisodium




MOLECULAR FORMULA : C30-H15-Fe-N3-O15-S3.3Na


WISWESSER LINE NOTATION : L66 BYVJ HSWO BUNO-FE-ONU- BL66 BYVJ HSWO&ONU-

BL66

BYVJ HSWO &-NA- 3



* C.I. 10020

* C.I. Acid Green 1

* C.I. Pigment Green 12

* D and C Green 1

* Ext D and C Green No. 1

* Iron, tris(5,6-dihydro-5,6-dioxo-2-naphthalenesulfonic acid-5-oximato)-,

trisodium salt

* Naphthol Green

* Naphthol Green B







TOXIC EFFECTS :


REFERENCE :



44,225,1978



















NAPHTHOLDISULFONIC ACID DISODIUM


CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid, 3-hydroxy-, disodium

salt




MOLECULAR FORMULA : C10-H6-O7-S2.2Na


WISWESSER LINE NOTATION : L66J CQ DSWO HSWO &-NA- 2



* Fericon

* 2-Naphthol-3,6-disulfonic acid sodium salt

* R salt






DOSE : 2 gm/kg


TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

publisher information, see FCTOD7. Volume(issue)/page/year: 11,355,1973




DOSE : 300 mg/kg


TOXIC EFFECTS :


REFERENCE :


For













NAPHTHOQUINONE (1,4-)


CHEMICAL NAME : 1,4-Naphthoquinone






WISWESSER LINE NOTATION : L66 BV EVJ


Tumorigen

Drug

Mutagen



* 1,4-Dihydro-1,4-diketonaphthalene

* 1,4-Naftochinon

* 1,4-Naphthalenedione

* alpha-Naphthoquinone


* USAF CY-10







TOXIC EFFECTS :



REFERENCE :

VKMGA7 Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene.

(Kiev,

USSR) V.6, 1966. For publisher information, see GNAMAP.






TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and

Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

V.1-36, 1957-1992. For publisher information, see MTPEEI






TOXIC EFFECTS :


Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-





DOSE/DURATION : 5500 ug/kg

TOXIC EFFECTS :

Tumorigenic - active as anti-cancer agent

REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,

Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,

DC






TOXIC EFFECTS :



REFERENCE :


&







TOXIC EFFECTS :



REFERENCE :


&







TOXIC EFFECTS :



REFERENCE :


(Kiev,







TOXIC EFFECTS :


REFERENCE :



NJ






DOSE/DURATION : 72800 ug/kg/26W-I

TOXIC EFFECTS :




levels - dehydrogenases

REFERENCE :








TOXIC EFFECTS :


Blood - methemoglobinemia-carboxyhemoglobin


REFERENCE :


(Kiev,







TOXIC EFFECTS :

Endocrine - changes in spleen weight

Blood - pigmented or nucleated red blood cells

Nutritional and Gross Metabolic - changes in iron

REFERENCE :









TOXIC EFFECTS :



Nutritional and Gross Metabolic - changes in iron

REFERENCE :








DOSE/DURATION : 72800 ug/kg/26W-I

TOXIC EFFECTS :





REFERENCE :









TOXIC EFFECTS :




REFERENCE :

PIATA8 Proceedings of the Imperial Academy of Tokyo. (Tokyo, Japan)

V.1-21,

1912-45. For publisher information, see PJACAW. Volume(issue)/page/year:

16,309,1940





DOSE : 5 mg/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

57,466,1955

** MUTATION DATA **




REFERENCE :



393,23,1997


OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993





NAPHTHOXYACETIC ACID (2-)

RTECS NUMBER : AI9659000

CHEMICAL NAME : Acetic acid, (2-naphthyloxy)-










* Acide naphthyloxyacetique

* Betapal

* Betoxon

* Gerlach 1396

* 2-Naphthalenoxyacetic acid

* (beta-Naphthalenyloxy)acetic acid

* beta-Naphthoxyacetic acid

* 2-Naphthoxyacetic acid

* O-(2-Naphthyl)glycolic acid

* (2-Naphthyloxy)acetic acid

* NOXA

* 2-Noxa







TOXIC EFFECTS :


REFERENCE :


Bridport


9,609,1991





54,7740,1989



NAPHTHYL ACETATE (1-)


CHEMICAL NAME : 1-Naphthol, acetate










* Acetic acid 1-naphthyl ester

* alpha-Acetoxynaphthalene

* 1-Acetoxynaphthalene

* 1-Naphthalenol, acetate

* alpha-Naphthol acetate

* alpha-Naphthyl acetate

* 1-Naphthyl acetate


** MUTATION DATA **




REFERENCE :



241,109,1990














NAPHTHYL ISOTHIOCYANATE (1-)

RTECS NUMBER : NX9100000

CHEMICAL NAME : Isothiocyanic acid, 1-naphthyl ester






MOLECULAR FORMULA : C11-H7-N-S


WISWESSER LINE NOTATION : L66J BNCS


Drug

Mutagen


* ANI

* ANIT

* 1-Isothiocyanate-naphthalene

* 1-Isothiocyanatonaphthalene

* Kesscocide

* 1-Naftylisothiokyanat

* Naphthalene, isothiocyanato-

* alpha-Naphthyl isothiocyanate

* 1-Naphthyl isothiocyanate







TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), zonal


REFERENCE :

JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96,

1892-1968. For publisher information, see JPTLAS.


76,175,1958





TOXIC EFFECTS :


REFERENCE :

CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China

International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)

V.11-






TOXIC EFFECTS :


REFERENCE :

JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)

V.61-79, 1978-87. For publisher information, see JNCIEQ.







TOXIC EFFECTS :

Liver - jaundice, other or unclassified



REFERENCE :

JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96,

1892-1968. For publisher information, see JPTLAS.


76,175,1958



SPECIES OBSERVED : Mammal - domestic


TOXIC EFFECTS :




REFERENCE :


For


** MUTATION DATA **




REFERENCE :

ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB

5050,

Tokyo International, Tokyo 100-31, Japan) V.25- 1961-





REFERENCE :


E.


11(Suppl 12),1,1988


TEST SYSTEM : Rodent - rat Liver


REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981


EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3

EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Host-mediated assay; E

coli polA with S9

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S

cerevisiae-homozygosis

EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; E coli

polA without S9


NAPHTHYLACETIC ACID (1-)


CHEMICAL NAME : 1-Naphthaleneacetic acid







WISWESSER LINE NOTATION : L66J B1VQ


Mutagen

Primary Irritant


* Acide naphthylacetique

* Agronaa

* Alman

* Alphaspra

* ANU

* Appl-set

* Biokor

* Celmone

* Fruitofix

* Fruitone N

* Kyselina 1-naftyloctova

* Klingtite

* Liqui-stik

* NAA

* alpha-Naa

* 1-NAA

* NAA 800

* Nafusaku

* Naphthaleneacetic acid

* Naphthalene-1-acetic acid

* alpha-Naphthaleneacetic acid

* alpha-Naphthylacetic

* Naphthylacetic acid

* alpha-Naphthylacetic acid

* 1-Naphthylacetic acid

* 2-(1-Naphthyl)acetic acid

* alpha-Naphthyleneacetic acid

* alpha-Naphthylessigsaeure

* Naphyl-1-essigsaeure

* Niagara-stik

* NU-Tone

* Phyomone

* Pimacol-sol

* Planofix

* Planofixe

* Plucker

* Pomoxon

* Primacol

* Rasin

* Rhodofix

* Stafast

* STIK

* Stop-Drop

* Tekkam

* Tip-Off

* Transplantone

* Tre-Hold

* Vardhak








REFERENCE :

PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400

Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-







TOXIC EFFECTS :


REFERENCE :

85DPAN "Wirksubstanzen der Pflanzenschutz und

Schadlingsbekampfungsmittel,"

Perkow, W., Berlin, Verlag Paul Parey, 1971-1976


-,-,1971/1976




DOSE/DURATION : >207 gm/m3

TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


University.







TOXIC EFFECTS :


REFERENCE :


University.







TOXIC EFFECTS :


REFERENCE :


University.







TOXIC EFFECTS :


REFERENCE :


Bridport


9,607,1991






TOXIC EFFECTS :

Behavioral - food intake (animal)



REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 5,371,1976





TOXIC EFFECTS :




REFERENCE :




** MUTATION DATA **




REFERENCE :

IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of

Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921-



TEST SYSTEM : Human Leukocyte

DOSE/DURATION : 100 nmol/L

REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,

Switzerland) V.1- 1945- Volume(issue)/page/year: 32,29,1976





54,7740,1989



















NAPHTHYLAMINE (BETA-)

RTECS NUMBER : QM2100000

CHEMICAL NAME : 2-Naphthylamine




MOLECULAR FORMULA : C10-H9-N


WISWESSER LINE NOTATION : L66J CZ


Mutagen


* 2-Aminonaftalen

* 2-Aminonaphthalene

* beta-Naftyloamina

* C.I. 37270

* Fast Scarlet Base B

* beta-Naftalamin

* beta-Naftilamina

* 2-Naftylamin

* 2-Naftylamine

* beta-Naftyloamina

* 2-Naphthalamine

* 2-Naphthalenamine

* beta-Naftylamin

* beta-Naphthylamin

* 2-Naphthylamin

* beta-Naphthylamine

* 6-Naphthylamine

* beta-Naphthylamine

* 2-Naphthylamine mustard


* USAF CB-22







TOXIC EFFECTS :


REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,466,1986





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Lungs, Thorax, or Respiration - cyanosis

Kidney, Ureter, Bladder - hematuria


REFERENCE :

XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington,

DC)







TOXIC EFFECTS :


Kidney, Ureter, Bladder - tumors

REFERENCE :




46,646,1982





TOXIC EFFECTS :



Tumorigenic - tumors at site of application

REFERENCE :



28,535,1968





TOXIC EFFECTS :




REFERENCE :

VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,

see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,

1928-37; V.1- 1955- Volume(issue)/page/year: 20(8),69,1974





TOXIC EFFECTS :



REFERENCE :



82,19,1986





TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :




REFERENCE :





ROUTE OF EXPOSURE : Parenteral



TOXIC EFFECTS :




REFERENCE :

BECCAN Annual Report--Cancer Research Campaign. (Cancer Research

Campaign,

2 Carlton House Terrace, London SW1Y 5AR, UK) V.1- 1924-



ROUTE OF EXPOSURE : Implant



TOXIC EFFECTS :



REFERENCE :




10,539,1956




DOSE/DURATION : 18 gm/kg/2Y-I

TOXIC EFFECTS :



REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC)

V.1-60,

1940-78. For publisher information, see JJIND8.


49,193,1972




DOSE/DURATION : 40 gm/kg/81W

TOXIC EFFECTS :



REFERENCE :





ROUTE OF EXPOSURE : Multiple routes



TOXIC EFFECTS :



REFERENCE :

AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal

Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1-

1925-




SPECIES OBSERVED : Primate - monkey


TOXIC EFFECTS :



REFERENCE :


V.1-60,



42,825,1969




DOSE/DURATION : 40 gm/kg/5Y

TOXIC EFFECTS :



REFERENCE :

LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-




SPECIES OBSERVED : Rodent - hamster


TOXIC EFFECTS :


Liver - tumors


REFERENCE :

85DAAC "Bladder Cancer, A Symposium, Fifth Inter-American Conference on

Toxicology and Occupational Medicine, Coral Gables, FL," Lampe, K.F., et

al., eds., Coral Gables, FL, Aesculapius Pub., 1966


5,129,1966

TYPE OF TEST : TD - Toxic dose (other than lowest)



DOSE/DURATION : 365 gm/kg/43W-C

TOXIC EFFECTS :


Liver - tumors


REFERENCE :

IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,

1949-73.

For publisher information, see IOHSA5. Volume(issue)/page/year:

35,564,1966




DOSE/DURATION : 108 mg/kg/4Y

TOXIC EFFECTS :



REFERENCE :







TOXIC EFFECTS :


Liver - tumors

REFERENCE :







TOXIC EFFECTS :



REFERENCE :







TOXIC EFFECTS :



REFERENCE :

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)

V.18-31, 1936-49. For publisher information, see AEHLAU.






TOXIC EFFECTS :



REFERENCE :

ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)

V.1-75,

1903-71. For publisher information, see JCROD7.


58,56,1951





TOXIC EFFECTS :



Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :


V.1-60,



41,985,1968





TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


Kidney, Ureter, Bladder - Kidney tumors


REFERENCE :



37,2943,1977




DOSE/DURATION : 94500 mg/kg/9Y-I

TOXIC EFFECTS :



REFERENCE :




44,892,1981

** MUTATION DATA **



DOSE/DURATION : 2500 ng/plate

REFERENCE :

PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,

52

Vanderbilt Ave., New York, NY 10017) V.1- 1981-


1,261,1981




REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.


NJ




DOSE/DURATION : 7 nmol/tube

REFERENCE :



147,79,1985




REFERENCE :


52



1,387,1981




REFERENCE :




TYPE OF TEST : DNA adduct



REFERENCE :



89,95,1981




REFERENCE :



41,532,1981




REFERENCE :



42,19,1977




REFERENCE :



42,19,1977




REFERENCE :


52



1,175,1981




REFERENCE :



368,235,1996





REFERENCE :



30,195,1970


TEST SYSTEM : Mold - Neurospora crassa


REFERENCE :



32,1890,1972




REFERENCE :


Pl.






REFERENCE :


52



1,414,1981




REFERENCE :


52



1,502,1981

TYPE OF TEST : Gene conversion and mitotic recombination


DOSE/DURATION : 50 ppm

REFERENCE :


52



1,481,1981




REFERENCE :


52



1,468,1981



TEST SYSTEM : Non-mammalian species


REFERENCE :



283,157,1992



TEST SYSTEM : Non-mammalian species


REFERENCE :



319,223,1993

TYPE OF TEST : Morphological transformation



REFERENCE :

ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher

information, see ICDBEO. Volume(issue)/page/year: 17,719,1981


TEST SYSTEM : Human Fibroblast


REFERENCE :



127,107,1984




REFERENCE :




TEST SYSTEM : Human HeLa cell


REFERENCE :



92,427,1982




REFERENCE :



93,447,1982



TEST SYSTEM : Rodent - rat


REFERENCE :



40,1157,1980


TEST SYSTEM : Rodent - rat Embryo


REFERENCE :


V.1-60,



51,799,1973




DOSE/DURATION : 1390 umol/kg

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-





REFERENCE :



113,357,1983




REFERENCE :






REFERENCE :



45,337,1985

TYPE OF TEST : Body fluid assay

TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium


REFERENCE :






DOSE/DURATION : 6 mg/kg/72H

REFERENCE :

NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in

Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,

Calcutta

700 019, India) V.1- 1958- Volume(issue)/page/year: 23,36,1980




REFERENCE :


52



1,570,1981



TEST SYSTEM : Rodent - mouse


REFERENCE :


52



1,698,1981




DOSE/DURATION : 300 mg/kg/3D (Continuous)

REFERENCE :



234,161,1990


TEST SYSTEM : Rodent - mouse Lymphocyte


REFERENCE :


E.


12(Suppl 13),37,1988





REFERENCE :



121,267,1983


TEST SYSTEM : Rodent - mouse Embryo


REFERENCE :


V.1-60,



52,1167,1974


TEST SYSTEM : Rodent - mouse Mammary gland


REFERENCE :



39,1784,1979


TEST SYSTEM : Rodent - mouse Ascites tumor


REFERENCE :



89,95,1981





REFERENCE :

ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit

Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-






REFERENCE :



108,225,1983

TYPE OF TEST : Mutation in mammalian somatic cells



REFERENCE :


52



1,580,1981

TYPE OF TEST : Host-mediated assay

TEST SYSTEM : Rodent - mouse Bacteria - Escherichia coli


REFERENCE :



272,161,1992


TEST SYSTEM : Rodent - hamster Embryo


REFERENCE :





TEST SYSTEM : Rodent - hamster Kidney


REFERENCE :


52



1,638,1981


TEST SYSTEM : Rodent - hamster Liver


REFERENCE :



136,255,1984




REFERENCE :


52



1,551,1981




REFERENCE :


52



1,551,1981




REFERENCE :



94,449,1982



TEST SYSTEM : Mammal - dog


REFERENCE :

EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-




TEST SYSTEM : Mammal - dog


REFERENCE :





TEST SYSTEM : Mammal - species unspecified Lymphocyte


REFERENCE :



368,235,1996

*** REVIEWS ***

ACGIH TLV-Confirmed human carcinogen




TLV/BEI,1997

IARC Cancer Review:Human Sufficient Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)


IARC Cancer Review:Animal Sufficient Evidence


Chemicals


12210)


IARC Cancer Review:Group 1

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-


7,261,1987

TOXICOLOGY REVIEW

KHZHAZ Khimiya i Zhizn. Chemistry and Life. (V/O Mezhdunarodnaya Kniga,

113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year:

12(2),85,1976

TOXICOLOGY REVIEW

ADCSAJ Advances in Chemistry Series. (American Chemical Soc.,

Distribution

Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1-


TOXICOLOGY REVIEW

BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New

York,

NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983


OSHA PEL (Construc):see CFR 29,1926.1109


Supt.


29,1926.55,1994

OSHA-cancer suspect agent


Supt.


29,1910.1009,1987


OEL-AUSTRALIA;Carcinogen JAN 1993

OEL-AUSTRIA: Skin, Carcinogen, JAN1999

OEL-BELGIUM;Carcinogen JAN 1993

OEL-FINLAND;Carcinogen JAN 1993

OEL-GERMANY;Skin;Carcinogen JAN 1993

OEL-SWEDEN;Carcinogen JAN 1993

OEL-SWITZERLAND;Skin;Carcinogen JAN 1993






NIOSH REL TO beta-NAPHTHYLAMINE-air:CA use 29 CFR 1910.1009

REFERENCE :



















EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal

assay

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE;

Host-mediated

assay

EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; N crassa-forward

mutation

EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine

reversion-Ames test

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; E coli polA

without S9

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S

cerevisiae-homozygosis

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal

EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation




NIOSH Analytical Method, 1994: Naphthylamines, 5518

NTP 8th Annual Report on Carcinogens, 1998: Known to be human carcinogen

NAPHTHYLETHYLENEDIAMINE

RTECS NUMBER : KV5330000

CHEMICAL NAME : Ethylenediamine, N-(1-naphthyl)-, dihydrochloride




MOLECULAR FORMULA : C12-H14-N2.2Cl-H


WISWESSER LINE NOTATION : L66J BM2Z &GH 2


Mutagen


* N-1-Naphthalenyl-1,2-ethanediamine dihydrochloride

* N-(1-Naphthyl)ethylenediamine dihydrochloride

* NCI-C03281







TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **




REFERENCE :


publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl

7),1,1986











EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat


NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat

NCITR* National Cancer Institute Carcinogenesis Technical Report Series.

(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Volume(issue)/page/year: NCI-TR-168,1979

NAPHTHYLPHTHALAMIC ACID (N,1-)

RTECS NUMBER : TH7350000

CHEMICAL NAME : Phthalamic acid, N-1-naphthyl-








WISWESSER LINE NOTATION : L66J BMVR BVQ



* Alanap

* Alanap 1

* Alanape

* Alanap 10G AT

* Ancrack

* Benzoic acid, 2-((1-naphthalenylamino)carbonyl)-

* Grelutin

* Kyselina N-1-naftylftalamova

* Mor-Cran

* Naftalam

* 2-((1-Naphthalenylamino)carbonyl)benzoic acid

* N-1-Naphthylphthalamate

* alpha-Naphthylphthalamic acid

* N-1-Naphthylphthalamic acid

* N-1-Naphthyl-phthalamidsaeure

* Naptalam







TOXIC EFFECTS :


REFERENCE :






DOSE/DURATION : >2070 mg/m3

TOXIC EFFECTS :


REFERENCE :


Bridport


9,613,1991





TOXIC EFFECTS :


REFERENCE :


Bridport


9,613,1991





54,7740,1989

NAPROXEN SODIUM


CHEMICAL NAME : 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,

sodium salt, L-(-)-




MOLECULAR FORMULA : C14-H14-O3.Na




Human


* Aleve

* Apranax

* L-(-)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt

* 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S)-

* Naprosyn sodium

* Naproxen sodium

* Sodium naprosyn

* Sodium naproxen







TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,

acute tubular necrosis)

Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :

AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn

St.,

Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-







TOXIC EFFECTS :




REFERENCE :

VHTODE Veterinary and Human Toxicology. (American College of Veterinary and

Comparative Toxicology, Publication Office, Comparative Toxicology,

Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year:

39,157,1997





TOXIC EFFECTS :





REFERENCE :

TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,

Akron, OH 44311) V.1- 1981- Volume(issue)/page/year:

36(1,pt2),147,1997





DOSE : 20 mg/kg


TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-





DOSE : 500 mg/kg


TOXIC EFFECTS :


REFERENCE :

FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave.

S,

Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 38,238,1982










NARINGIN


CHEMICAL NAME : Naringin








* Naringenin-7-beta-neohesperidoside

* Naringoside







TOXIC EFFECTS :


REFERENCE :

EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6,

Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980





TOXIC EFFECTS :


REFERENCE :

EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6,

Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980



NEODYMIUM

RTECS NUMBER : QO8575000

CHEMICAL NAME : Neodymium




MOLECULAR FORMULA : Nd


WISWESSER LINE NOTATION : ND

COMPOUND DESCRIPTOR : Human




ROUTE OF EXPOSURE : Intracerebral



TOXIC EFFECTS :


Gastrointestinal - other changes


REFERENCE :

JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230

York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year:

21,447,1942












NEOMYCIN SULFATE

RTECS NUMBER : QP4375000

CHEMICAL NAME : Neomycin, sulfate (salt)





WISWESSER LINE NOTATION : T6OTJ CZ DQ EQ F1Z BO- CT5OTJ B1Q DQ EO- CL6TJ AZ

BQ

EZ DO- BT6OTJ CZ DQ EQ F1Z &WSQQ


Mutagen

Human

Primary Irritant


* Biosol veterinary

* Bykomycin

* Fradiomycin sulfate

* Lidamycin creme

* Mycifradin-N

* Mycaifradin sulfate

* Mycigient

* Neobiotic

* Neofracin

* Neo-mantle creme

* Neomix

* Neomycine sulfate

* Neomycin sulphate

* New France F

* Otobiotic

* Quintess-N

* USAF CB-19






DOSE/DURATION : 6 mg/3D (Intermittent)


REFERENCE :

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"

Drill,

V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977

Volume(issue)/page/year: -,127,1977






TOXIC EFFECTS :


Behavioral - hallucinations, distorted perceptions

Behavioral - anorexia (human)

REFERENCE :

ARSUAX Archives of Surgery (Chicago). (AMA, 535 N. Dearborn St.,

Chicago,

IL 60610) V.1-61, 1920-50; V.81- 1960- Volume(issue)/page/year:

111,822,1976





TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : >8 gm(base)/kg

TOXIC EFFECTS :


REFERENCE :




-,138,1963





TOXIC EFFECTS :


REFERENCE :

ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)

V.1-12, 1951-62. For publisher information, see CLMEA3.






TOXIC EFFECTS :


REFERENCE :

ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher

information, see AMBIEH. Volume(issue)/page/year: 18,444,1973





TOXIC EFFECTS :


REFERENCE :

AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona,

POB

1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year:

10,947,1962


ROUTE OF EXPOSURE : Intramuscular



TOXIC EFFECTS :


REFERENCE :

AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St.,

Chicago,

IL 60610) V.1- 1908- Volume(issue)/page/year: 119,493,1967





TOXIC EFFECTS :


REFERENCE :



7,361,1965





TOXIC EFFECTS :

Sense Organs and Special Senses (Ear) - change in acuity

REFERENCE :



33,320,1975






TOXIC EFFECTS :




levels - phosphatases

REFERENCE :

CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,

Toxicology

and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY






TOXIC EFFECTS :


Kidney, Ureter, Bladder - other changes in urine composition


levels - other Enzymes

REFERENCE :

CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,

Toxicology

and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY






TOXIC EFFECTS :

Sense Organs and Special Senses (Ear) - change in acuity

Sense Organs and Special Senses (Ear) - changes in cochlear structure or

function


REFERENCE :



33,320,1975

*** REVIEWS ***

TOXICOLOGY REVIEW

PMMDAE Panminerva Medica. (Edizioni Minerva Medica, Casella Postale 491,

Turin, Italy) V.1- 1959- Volume(issue)/page/year: 16,9,1974





54,7740,1989


















EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-rat


NEON

RTECS NUMBER : QP4450000

CHEMICAL NAME : Neon




MOLECULAR FORMULA : Ne


WISWESSER LINE NOTATION : .NE


* Neon

*** REVIEWS ***

ACGIH TLV-Simple asphyxiant, NO TWA




TLV/BEI,1997


MSHA STANDARD:ASPHYXIANTS/GASES

DTLWS* "Documentation of the Threshold Limit Values for Substances in

Workroom Air," Supplements. For publisher information, see 85INA8.


simple asphyxiant-inert gases and vapors


Supt.


29,1926.55,1994


OEL-AUSTRARALIA:Asphyxiant JAN 1993

OEL-BELGIUM:Asphyxiant JAN 1993

OEL-HUNGARY:Asphyxiant JAN 1993

OEL-THE NETHERLANDS:Asphyxiant JAN 1993

OEL-SWITZERLAND:Asphyxiant JAN 1993

OEL-UNITED KINGDOM:Asphyxiant JAN 1993




















NEOPENTYL GLYCOL DIACRYLATE

RTECS NUMBER : AS8925000

CHEMICAL NAME : Acrylic acid, 2,2-dimethyltrimethylene ester






WISWESSER LINE NOTATION : 1U1VO1X1&1&1OV1U1


Primary Irritant


* Acrylic acid, 2,2-dimethyl-1,3-propanediol diester

* Dimethylolpropane diacrylate

* 2,2-Dimethyltrimethylene acrylate

* Neopentyl glycol diacrylate

* 1,3-Propanediol, 2,2-dimethyl-, diacrylate

* 2-Propenoic acid, 2,2-dimethyl-1,3-propanediyl ester

* SR 247

* Viscoat 247








REFERENCE :







DOSE/DURATION : 5190 uL/kg

TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :














EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE



47,26992,82



NEUTRAL RED

RTECS NUMBER : SG1400000

CHEMICAL NAME : Phenazine, 3-amino-7-(dimethylamino)-2-methyl-,

hydrochloride




MOLECULAR FORMULA : C15-H16-N4.Cl-H


WISWESSER LINE NOTATION : T C666 BN INJ E1 FZ LN1&1 &GH


Mutagen

Natural Product


* 3-Amino-7-dimethylamino-2-methylphenazine hydrochloride

* Aminodimethylaminotoluaminozine hydrochloride

* Cerven neutralni

* Cerven toluylenova

* Cerven zasadita 5

* C.I. 50040

* C.I. Basic Red 5

* C.I. Basic Red 5, monohydrochloride

* Kernechtrot

* Michrome No. 226

* Neutral Red

* Neutral Red chloride

* Neutral Red W

* Nuclear Fast Red

* Phenazine, 3-amino-7-(dimethylamino)-2-methyl-, monohydrochloride

* Toluylene Red

* N(sup 8),N(sup 8),3-Trimethyl-2,8-phenazinediamine monohydrochloride







TOXIC EFFECTS :


Cardiac - other changes


REFERENCE :

FEPRA7 Federation Proceedings, Federation of American Societies for

Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.






TOXIC EFFECTS :


REFERENCE :

ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China

International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-






TOXIC EFFECTS :


Cardiac - other changes


REFERENCE :








TOXIC EFFECTS :


Lungs, Thorax, or Respiration - respiratory stimulation


REFERENCE :

SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62.

Discontinued. Volume(issue)/page/year: 9,96,1951

** MUTATION DATA **




REFERENCE :

AEMIDF Applied and Environmental Microbiology. (American Soc. for





DOSE/DURATION : 2500 ppt/3H

REFERENCE :

AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB

37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year:

85,119,1951



DOSE/DURATION : 2 ug/well

REFERENCE :






REFERENCE :

FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29

Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year:

22,329,1977





REFERENCE :

AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB


87,295,1953



TEST SYSTEM : Fish - not otherwise specified

DOSE/DURATION : 1 ppm/4D (Continuous)

REFERENCE :



64,205,1979




REFERENCE :



93,185,1982





REFERENCE :

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.

Ireland

Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:

22,287,1978



DOSE/DURATION : 2 umol/L/5H

REFERENCE :



45,233,1977



TEST SYSTEM : Bird - chicken


REFERENCE :

47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,

Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:

-,137,1982



TEST SYSTEM : Bird - chicken


REFERENCE :

47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,

Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:

-,137,1982

















EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy

EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal


NEW COCCINE


CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,

3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium

salt





MOLECULAR FORMULA : C20-H14-N2-O10-S3.3Na


WISWESSER LINE NOTATION : L66J CO HSWO JSWO BNUN- BL66J ESWO &-NA- 4


Mutagen


* Acidal Bright Ponceau 3R

* Acid Brilliant Scarlet 3R

* Acid Ponceau 4R

* Acid Red 18

* Acid Scarlet 3R

* Acid Scarlet 4R

* Acid Scarlet 3RZ

* Acilan Scarlet V3R

* Aizen Brilliant Scarlet 3RH

* Atul Acid Scarlet 3R

* Atul Scarlet F

* Brilliant Ponceau 3R



* Brilliant Ponceau 4RC

* Brilliant Ponceau 4RC Specially Pure

* Brilliant Ponceau 3RF

* Brilliant Scarlet

* Brilliant Scarlet 3R

* Brilliant Scarlet 4R

* Bucacid Brilliant Scarlet 3R

* Calcocid Brilliant Scarlet 3RN

* Certicol Ponceau 4RS

* Cerven kosenilova A

* Cerven kysela 18

* Cerven potravinarska 7

* Cilefa Ponceau 4R

* Coccine

* Coccine nouvelle

* Coccin Red

* Cochenillerot A

* Cochineal Red A

* Cochineal Red A Specially Pure

* Cochineal Red 4R

* Colacid Ponceau 4R

* C.I. 185

* C.I. 16255

* C.I. Acid Red 18

* C.I. Acid Red 18, trisodium salt

* C.I. Food Red 7

* Crimson SX

* Curol Bright Red 4R

* Daishiki Brilliant Scarlet 3R

* E 124

* Edicol Supra Ponceau 4R

* Eurocert Cochineal Red A

* Fenazo Scarlet 3R

* Food Red 6

* Food Red 7

* Food Red No. 102

* HD Ponceau 4R

* HD Ponceau 4R Supra

* Hexacol Ponceau 4R

* Hidacid Fast Scarlet 3R

* Hispacid Brilliant Scarlet 3RF

* Java Scarlet 3R

* Kayaku Acid Brilliant Scarlet 3R

* Kayaku Food Colour Red No. 102

* Kiton Scarlet 4R

* Kochineal Red A for food

* L-Rot 4

* Naphthalene Ink Scarlet 4R

* Naphthalene Scarlet 4R

* Naphthalene Scarlet 4RS

* Neklacid Red 3R

* Neklacid Red 4R

* Neucoccin

* New coccin

* New coccine

* New Coccine Extra Conc. A Export

* New Coccine Extra Pure A

* Ponceau 4R

* Ponceau 4R Aluminum Lake

* Ponceau 4RE

* Ponceau 4RE.FQ

* Ponceau 4RF

* Ponceau 4RT

* Pontacyl Scarlet RR

* Purple Red

* Purple SX

* Rakuto Brilliant Scarlet 3R

* 1578 Red

* Rouge de cochenille A

* San-ei Brilliant Scarlet 3R

* Schultz Nr. 213

* Strawberry Red A Geigy

* Sugai Brilliant Scarlet 3R

* 1-(4-Sulpho-1-naphthylazo)-2-naphthol-6,8-disulphonic acid, trisodium

salt

* SX purple

* Symulon Acid Brilliant Scarlet 3R

* Takaoka Brilliant Scarlet 3R

* Victoria Scarlet 3R

* Victoria Scarlet Red

* Victoria Scharlach 4 R Extra







TOXIC EFFECTS :





REFERENCE :


For






TOXIC EFFECTS :



Behavioral - coma

REFERENCE :


For






TOXIC EFFECTS :


REFERENCE :

SCPHA4 Scientia Pharmaceutica. (Oesterreichische

Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9,

Austria)






TOXIC EFFECTS :


REFERENCE :

NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association.

(Nara

Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken,






TOXIC EFFECTS :


REFERENCE :

SCPHA4 Scientia Pharmaceutica. (Oesterreichische

Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9,

Austria)






TOXIC EFFECTS :



Behavioral - coma

REFERENCE :


For







TOXIC EFFECTS :




REFERENCE :


For






TOXIC EFFECTS :




REFERENCE :

TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,

101479,

Russia) History Unknown Volume(issue)/page/year: (2),34,1996




DOSE/DURATION : 48 mg/m3/17W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea

or bronchi



REFERENCE :

TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,

101479,

Russia) History Unknown Volume(issue)/page/year: (2),34,1996






TOXIC EFFECTS :


Liver - tumors

REFERENCE :

VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya

Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-


** MUTATION DATA **


TEST SYSTEM : Rodent - hamster Fibroblast


REFERENCE :

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell

House,

Fairview Park, Elmsford, NY 10523) V.20- 1982-


22,623,1984

















EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion



NIACINAMIDE

RTECS NUMBER : QS3675000

CHEMICAL NAME : Nicotinamide




MOLECULAR FORMULA : C6-H6-N2-O


WISWESSER LINE NOTATION : T6NJ CVZ


Mutagen


* Acid amide

* Amide PP

* Amid kyseliny nikotinove

* Aminicotin

* m-(Aminocarbonyl)pyridine

* Amixicotyn

* Amnicotin

* Austrovit PP

* Benicot

* 3-Carbamoylpyridine

* Delonin amide

* Dipegyl

* Endobion

* Factor PP

* Hansamid

* Inovitan PP

* NAM

* Niacevit

* Niacinamide

* Niavit PP

* Nicamindon

* Nicasir

* Nicobion

* Nicofort

* Nicogen

* Nicomidol

* Nicosan 2

* Nicotamide

* Nicotilamide

* Nicotinic acid amide

* Nicotinic amide

* Nicotinsaureamid

* Nicotylamide

* Nicovit

* Nicovitol

* Nicozymin

* Niko-Tamin

* Nikotinsaeureamid

* Niocinamide

* Niozymin

* Pelmine

* Pelonin amide

* PP-Faktor

* Pyridine-3-carboxylic acid amide

* 3-Pyridinecarboxamide

* 3-Pyridinecarboxylic acid amide

* Savacotyl

* VI-Nicotyl

* Vitamin B

* Vitamin B3

* Vitamin PP

* Witamina PP







TOXIC EFFECTS :


REFERENCE :



-,1390,1986





TOXIC EFFECTS :


REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-






TOXIC EFFECTS :


REFERENCE :


Japan) Volume(issue)/page/year: 6,545,1982





TOXIC EFFECTS :


REFERENCE :

RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St.,

Duluth,

MN 55802) V.1- 1954- Volume(issue)/page/year: 109,479,1987





TOXIC EFFECTS :


REFERENCE :

QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)

V.2-21,

1929-48. For publisher information, see JPPMAB.


19,48,1946



SPECIES OBSERVED : Mammal - species unspecified


TOXIC EFFECTS :


REFERENCE :


Translation



** MUTATION DATA **



DOSE/DURATION : 5 mg/plate

REFERENCE :

TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of

Tokyo

Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei

Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan)

V.1-

1949/50- Volume(issue)/page/year: 37,447,1986




REFERENCE :



Calcutta





REFERENCE :





TEST SYSTEM : Rodent - rat Ovary


REFERENCE :



143,263,1985




REFERENCE :



126,63,1984




















NICKEL

RTECS NUMBER : QR5950000

CHEMICAL NAME : Nickel




MOLECULAR FORMULA : Ni


WISWESSER LINE NOTATION : NI


Mutagen



* Alcan 756

* Carbonyl nickel powder

* C.I. 77775

* EL12

* Fibrex

* Fibrex P

* Ni 270

* Nichel

* Nickel 270

* Nickel, metal

* Nickel particles

* Nickel sponge

* Ni 0901-S

* Ni 4303T

* NP 2

* Raney alloy

* Raney nickel







TOXIC EFFECTS :


REFERENCE :

FDRLI* Food & Drug Research Laboratories, Inc., Papers. (P.O. Box 107,

Rt.

17C, Waverly, NY 14892-0107) Volume(issue)/page/year: 7684D,1983





TOXIC EFFECTS :

Vascular - regional or general arteriolar or venous dilation



REFERENCE :

INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher

information, see IOHSA5. Volume(issue)/page/year: 15,482,1946


ROUTE OF EXPOSURE : Intratracheal



TOXIC EFFECTS :


REFERENCE :



Volume(issue)/page/year: AEC-TR-6710





TOXIC EFFECTS :


Behavioral - fluid intake

Kidney, Ureter, Bladder - proteinuria

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see

PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka

Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-







TOXIC EFFECTS :

Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)


REFERENCE :







DOSE/DURATION : 100 ug/m3/24H/17W-C

TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :



REFERENCE :







DOSE/DURATION : 1700 ug/m3/6H/5W-I

TOXIC EFFECTS :


Lungs, Thorax, or Respiration - changes in lung weight


REFERENCE :

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,






TOXIC EFFECTS :



REFERENCE :






DOSE/DURATION : 1 mg/m3/6H/26W-I

TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :



REFERENCE :









TOXIC EFFECTS :




REFERENCE :


V.1-60,



16,55,1955





TOXIC EFFECTS :


Musculoskeletal - tumors


REFERENCE :

IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan

Ave.,

Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 53,127,1984


ROUTE OF EXPOSURE : Intrapleural



TOXIC EFFECTS :



REFERENCE :

PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of

California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-






TOXIC EFFECTS :




REFERENCE :

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle

St.,


5,445,1962





TOXIC EFFECTS :




REFERENCE :


V.1-60,



16,55,1955





TOXIC EFFECTS :



REFERENCE :

NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the

National Cancer Institute by The Institute of Chemical Biology,

University

of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:

PH43-64-886





TOXIC EFFECTS :




REFERENCE :


V.1-60,



16,55,1955




DOSE/DURATION : 15 mg/m3/91W-I

TOXIC EFFECTS :



Lungs, Thorax, or Respiration - bronchiogenic carcinoma

REFERENCE :

AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60.

For

publisher information, see APLMAS. Volume(issue)/page/year: 65,600,1958





TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



REFERENCE :

PAACA3 Proceedings of the American Association for Cancer Research.

(Waverly

Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-






TOXIC EFFECTS :



REFERENCE :


V.1-60,



16,55,1955





TOXIC EFFECTS :



REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :



REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :



REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :




REFERENCE :

JPTLAS Journal of Pathology. (John Wiley & Sons, Inc., 605 Third Ave.,

New

York, NY 10158) V.97- 1969- Volume(issue)/page/year: 97,375,1969





TOXIC EFFECTS :




REFERENCE :

TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX)

V.1-41(2),

1943-81/82. Discontinued. Volume(issue)/page/year: 10,167,1952





TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



REFERENCE :


(Waverly







DOSE : 158 mg/kg

SEX/DURATION : multigenerations

TOXIC EFFECTS :




REFERENCE :

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle

St.,


23,102,1971

** MUTATION DATA **




REFERENCE :


Ave.,





REFERENCE :


Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,132,1981

*** REVIEWS ***

ACGIH TLV-TWA 1 mg/m3




TLV/BEI,1997



Chemicals


12210)






7,264,1987

IARC Cancer Review:Human Inadequate Evidence


Chemicals


12210)


IARC Cancer Review:Group 2B


Chemicals


12210)


TOXICOLOGY REVIEW

ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,

Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year:

3,156,1973

TOXICOLOGY REVIEW

KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control.

(Kogai

Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka,

Minato-ku,

Tokyo 107, Japan) V.1- 1965- Volume(issue)/page/year: 11,1300,1975

TOXICOLOGY REVIEW

MIBUBI Mikrobiyoloji Bulteni. Bulletin of Microbiology. (c/o Dr. A.

Tevfik

Cenqiz, Ankara Universitesi Tip Fakultesi Mikrobiyoloji Ana Bilim Dah,

Ankara, Turkey) V.1- 1967- Volume(issue)/page/year: 9,321,1975

TOXICOLOGY REVIEW


For


TOXICOLOGY REVIEW

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"

Washington, DC, National Academy of Sciences, 1972-77

Volume(issue)/page/year: Ni,168,1975

TOXICOLOGY REVIEW

85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer

Congress," Chicago, Year Book Medical Pub., 1971


5,63,1970

TOXICOLOGY REVIEW

31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays,

International Symposium, 1974," Karbe, E., and J.F. Park, eds.,

Springer-Verlag New York, Inc., 1974 Volume(issue)/page/year: -,93,1974

TOXICOLOGY REVIEW



Volume(issue)/page/year: CONF-691001

TOXICOLOGY REVIEW

GSAMAQ Memoir--Geological Society of America. (POB 9140, Boulder, CO

80302)

No.1- 1934- Volume(issue)/page/year: 123,109,1971

TOXICOLOGY REVIEW

PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach

CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:

12,102,1969

TOXICOLOGY REVIEW

DICHAK Diseases of the Chest. (Chicago, IL) V.1-56, 1935-69. For

publisher information, see CHETBF. Volume(issue)/page/year: 54,527,1968

TOXICOLOGY REVIEW

AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605

Third

Ave., New York, NY 10016) V.1, 1976-79. Discontinued.



MSHA STANDARD-air:TWA 1 mg/m3




OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3


Supt.


29,1910.1000,1994

OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3


Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 0.1 mg/m3 JAN 1993

OEL-AUSTRIA: Carcinogen, JAN1999

OEL-AUSTRALIA:TWA 1 mg/m3 JAN 1993

OEL-BELGIUM:TWA 1 mg/m3 (insoluble compounds) JAN 1993

OEL-JAPAN: OEL 1 mg/m3, 2B Carcinogen, JAN1999

OEL-POLAND: MAC(TWA) 0.25 mg/m3, JAN1999

OEL-FINLAND:TWA 0.1 mg/m3;Skin;Carcinogen (insoluble compounds) JAN 1993

OEL-GERMANY;Carcinogen JAN 1993

OEL-HUNGARY:STEL 0.005 mg/m3;Carcinogen (insoluble compounds) JAN 1993

OEL-JAPAN:TWA 1 mg/m3;Carcinogen JAN 1993

OEL-THE NETHERLANDS:TWA 0.1 mg/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 1 mg/m3 (insoluble compounds) JAN 1993

OEL-THE PHILIPPINES:TWA 1 mg/m3 JAN 1993


OEL-SWEDEN:TWA 0.5 mg/m3 (dust) JAN 1993

OEL-SWITZERLAND:TWA 0.5 mg/m3 (insoluble compounds) JAN 1993

OEL-SWITZERLAND:TWA 0.5 mg/m3;Carcinogen JAN 1993

OEL-THAILAND:TWA 1 mg/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 0.5 mg/m3 (insoluble compounds) JAN 1993

OEL-UNITED KINGDOM:TWA 0.5 mg/m3 (dust) JAN 1993

OEL-UNITED KINGDOM:TWA 1 mg/m3 JAN 1993





NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3

REFERENCE :













































ATSDR TOXICOLOGY PROFILE



Volume(issue)/page/year: PB/89/160378/AS

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat




NIOSH Analytical Method, 1994: Elements by ICP, 7300

NIOSH Analytical Method, 1994: Metals in urine, 8310

NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005

NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be

Human Carcinogen

OSHA ANALYTICAL METHOD #ID-125G

NICKEL BISCYCLOPENTADIENE


CHEMICAL NAME : Nickel, compd with pi-cyclopentadienyl (1:2)




MOLECULAR FORMULA : C10-H10-Ni


WISWESSER LINE NOTATION : L50J 0-NI- 0L50J



* pi-Cyclopentadienyl compd. with nickel

* Di-pi-cyclopentadienylnickel

* Nickel biscyclopentadiene

* Nickelocene

* Nikelocen







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :


REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :



Gastrointestinal - hypermotility, diarrhea

REFERENCE :








TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :



REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :




REFERENCE :



University


PH43-64-886





TOXIC EFFECTS :



REFERENCE :



University


PH43-64-886

*** REVIEWS ***



Chemicals


12210)


IARC Cancer Review:Animal Limited Evidence


Chemicals


12210)


TOXICOLOGY REVIEW




TOXICOLOGY REVIEW



3,156,1973

TOXICOLOGY REVIEW

PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach

CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:

12,102,1969




Human Carcinogen

NICKEL SULFATE


CHEMICAL NAME : Nickel(II) sulfate (1:1)




MOLECULAR FORMULA : O4-S.Ni


WISWESSER LINE NOTATION : NI S-O4


Mutagen

Primary Irritant


* NCI-C60344

* Nickelous sulfate

* Nickel sulfate

* Nickel sulfate(1:1)

* Nickel(II) sulfate

* Nickel(2+)sulfate(1:1)

* Sulfuric acid, nickel(2+)salt

* Sulfuric acid, nickel(2+) salt (1:1)






DOSE/DURATION : 5%/48H

REFERENCE :

ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL







TOXIC EFFECTS :

Behavioral - muscle contraction or spasticity


Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :









TOXIC EFFECTS :


REFERENCE :

COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.

(Paris, France) V.1-261, 1835-1965. For publisher information, see

CRASEV.






TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :

JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea

or bronchi

REFERENCE :









TOXIC EFFECTS :


Endocrine - changes in thymus weight

Immunological Including Allergic - decreased immune response

REFERENCE :









TOXIC EFFECTS :



REFERENCE :


(Waverly



** MUTATION DATA **




REFERENCE :



117,149,1983




REFERENCE :



117,149,1983




REFERENCE :



47,3815,1987


TEST SYSTEM : Human Kidney


REFERENCE :



49,1829,1989




REFERENCE :


(Waverly




TEST SYSTEM : Human Leukocyte


REFERENCE :

DMBUAE Danish Medical Bulletin. (Copenhagen, Denmark) V.1-18, 1954-71.





REFERENCE :



49,1829,1989




REFERENCE :



39,193,1979

*** REVIEWS ***

ACGIH TLV-TWA 0.1 mg(Ni)/m3




TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)


TOXICOLOGY REVIEW



3,156,1973

TOXICOLOGY REVIEW





MSHA STANDARD-air:TWA 1 mg(Ni)/m3




3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3 JAN 1993

OEL-AUSTRALIA:TWA 1 mg(Ni)/m3 JAN 1993

OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-DENMARK: TWA 0.1 mg(Ni)/m3, JAN1999

OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;Carcinogen (insoluble compounds) JAN

1993

OEL-POLAND: MAC(TWA) 0.25 mg(Ni)/m3, JAN1999


OEL-HUNGARY:STEL 0.005 mg(Ni)/m3;Carcinogen (insoluble compounds) JAN

1993

OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen JAN 1993

OEL-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3 JAN 1993

OEL-RUSSIA:STEL 0.05 mg(Ni)/m3 JAN 1993

OEL-SWEDEN:TWA 0.5 mg(Ni)/m3 JAN 1993

OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3;Carcinogen JAN 1993

OEL-THAILAND:TWA 1 mg(Ni)/m3 JAN 1993

OEL-UNITED KINGDOM:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993

OEL-UNITED KINGDOM:TWA 1 mg(Ni)/m3 JAN 1993






REFERENCE :



















EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE

EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat



NICKEL SULFATE HEXAHYDRATE


CHEMICAL NAME : Nickel(II) sulfate hexahydrate (1:1:6)




MOLECULAR FORMULA : Ni-O4-S.6H2-O


WISWESSER LINE NOTATION : NI S-O4 &QH 6


Tumorigen

Mutagen



* Nickel monosulfate hexahydrate

* Nickelous sulfate hexahydrate

* Nickel sulfate hexahydrate

* Nickel(II) sulfate hexahydrate

* Nickel(2+) sulfate hexahydrate

* Nickel sulphate hexahydrate

* Sulfuric acid, nickel(2+) salt, hexahydrate







TOXIC EFFECTS :




REFERENCE :

ATDAEI Acute Toxicity Data. Journal of the American College of

Toxicology,

Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)

V.1-






TOXIC EFFECTS :


REFERENCE :

EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.

Rep.

Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975





TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.







TOXIC EFFECTS :

Cardiac - changes in heart weight



REFERENCE :

JFSTAB Journal of Food Science and Technology. (Assoc. of Food

Scientists

and Technologists (India), Central Food Technological Research Institute,

Mysore, 570013, India) V.1- 1964- Volume(issue)/page/year:

13,181,1976





TOXIC EFFECTS :


Kidney, Ureter, Bladder - changes in both tubules and glomeruli


REFERENCE :



36(1,pt2),278,1997





TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise

specified



REFERENCE :







DOSE/DURATION : 3582 ug/m3/6H/12D-I

TOXIC EFFECTS :


specified



REFERENCE :







TOXIC EFFECTS :

Endocrine - hypoglycemia


Biochemical - Metabolism (Intermediary) - amino acids (including renal

excretion)

REFERENCE :








TOXIC EFFECTS :




REFERENCE :

CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,

Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 8,893,1979





TOXIC EFFECTS :


Biochemical - Metabolism (Intermediary) - Plasma proteins not involving

coagulation

REFERENCE :



9,211,1981





TOXIC EFFECTS :


Blood - changes in other cell count (unspecified)



REFERENCE :







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :




REFERENCE :

JFSTAB Journal of Food Science and Technology. (Assoc. of Food

Scientists

and Technologists (India), Central Food Technological Research Institute,

Mysore, 570013, India) V.1- 1964- Volume(issue)/page/year:

13,181,1976





DOSE : 403 mg/kg

SEX/DURATION : male 30 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - other effects on male

REFERENCE :


D-1000


37,159,1977

** MUTATION DATA **





REFERENCE :



170,115,1986




REFERENCE :


E.


24,23,1994




REFERENCE :






REFERENCE :






REFERENCE :



300,179,1993




REFERENCE :


E.


24,23,1994




REFERENCE :


E.


24,23,1994




REFERENCE :


E.


12,85,1988




REFERENCE :

DTESD7 Developments in Toxicology and Environtal Science. (Elsevier

Science, New York, NY) V.1-15, 1977-87. Discontinued





REFERENCE :






REFERENCE :






REFERENCE :



104,141,1982

*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)






54,7740,1989





3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994






OEL-BELGIUM:TWA 1 mg(Ni)/m3 JAN 1993


1993




1993

















REFERENCE :














EPA GENETOX PROGRAM 1988, Positive/dose response: SHE-clonal assay


NTP Carcinogenesis studies (inhalation);no evidence:mouse,rat



NTP-TR-454,1996

NICKEL(II) ACETATE TETRAHYDRATE


CHEMICAL NAME : Nickel acetate tetrahydrate




MOLECULAR FORMULA : C4-H6-O4.Ni.4H2-O


WISWESSER LINE NOTATION : OV1 2 &-NI- &QH 4


Mutagen


* Acetic acid, nickel(+2) salt, tetrahydrate

* Diacetatonickel tetrahydrate

* Nickel(II) acetate tetrahydrate

* Nickel diacetate tetrahydrate

* Nickelous acetate tetrahydrate







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

RCOCB8 Research Communications in Chemical Pathology and Pharmacology.

(PJD

Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-


** MUTATION DATA **



DOSE/DURATION : 11 ug/well

REFERENCE :



260,349,1991





REFERENCE :







REFERENCE :



68,337,1979

*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)







3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994




REFERENCE :




NICKEL(II) ACETYLACETONATE

RTECS NUMBER : SA2100000

CHEMICAL NAME : 2,4-Pentanedione, nickel(II) deriv.




MOLECULAR FORMULA : C10-H14-Ni-O4


WISWESSER LINE NOTATION : 1V1V1 &-NI-


* Acetylacetonatonickel (II)

* Bis(acetylacetonate)nickel

* Bis(acetylacetonato)nickel

* Bis(acetylacetone)nickel

* Bis(2,4-pentanedionato)nickel

* Nickel acetylacetonate

* Nickel bis(acetylacetonate)

* Nickel bis(2,4-pentanedionate)

* Nickel, bis(2,4-pentanedionato-O,O')-, (SP-4-1)

* Nickel(II) acetylacetonate

* Nickelous acetylacetonate







TOXIC EFFECTS :


REFERENCE :








REFERENCE :














NICKEL(II) CARBONATE


CHEMICAL NAME : Nickel(II) carbonate (1:1)




MOLECULAR FORMULA : C-Ni-O3


WISWESSER LINE NOTATION : QVQ &-NI-


Mutagen


* Carbonic acid, nickel salt (1:1)

* C.I. 77779

* Nickel(2+) carbonate

* Nickel monocarbonate

* Nickelous carbonate







TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia

(usually neuromuscular blockage)



REFERENCE :








TOXIC EFFECTS :



REFERENCE :


(Waverly



** MUTATION DATA **




DOSE/DURATION : 10 mg/kg/3H

REFERENCE :



42,3544,1982





REFERENCE :



44,3892,1984

*** REVIEWS ***

ACGIH TLV-TWA 1 mg(Ni)/m3




TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)


TOXICOLOGY REVIEW



3,156,1973

TOXICOLOGY REVIEW


For


TOXICOLOGY REVIEW









3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994




OEL-SWEDEN:TWA 0.1 mg/m3;Carcinogen JAN 1993

OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin;Carcinogen JAN 1993

OEL-DENMARK: TWA 1 mg(Ni)/m3, JAN1999

OEL-FRANCE: VME 1 mg, JAN1999







REFERENCE :





















Human Carcinogen

NICKEL(II) CHLORIDE


CHEMICAL NAME : Nickel(II) chloride (1:2)





MOLECULAR FORMULA : Cl2-Ni


WISWESSER LINE NOTATION : NI G2


Mutagen



* Nickel chloride

* Nickel dichloride

* Nickelous chloride







TOXIC EFFECTS :



REFERENCE :

INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas

Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


REFERENCE :


&








TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : 402 mg/kg/1Y-C

TOXIC EFFECTS :

Cardiac - changes in coronary arteries

Nutritional and Gross Metabolic - changes in sodium


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Kidney, Ureter, Bladder - urine volume decreased



REFERENCE :



31,55,1975





TOXIC EFFECTS :





REFERENCE :

TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,

Warner-Lambert

Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)

V.6(3/4)-






TOXIC EFFECTS :


REFERENCE :







DOSE : 1170 ug/kg

SEX/DURATION : female 30 week(s) pre-mating

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in

number of implants per female; total number of implants per corpora lutea)



REFERENCE :







DOSE : 10 gm/kg

SEX/DURATION : male 11 week(s) pre-mating

female 11 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - weaning or lactation index (e.g., #

alive at weaning per # alive at day 4)


gain)

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development.

(Alan

R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

Volume(issue)/page/year: 33,90C,1986




DOSE : 5 mg/kg


female 90 day(s) pre-mating - 21 day(s) after

conception

TOXIC EFFECTS :



4

per # born alive)


gain)

REFERENCE :






DOSE : 4426 ug/kg

SEX/DURATION : female 12 day(s) after conception

TOXIC EFFECTS :



REFERENCE :






DOSE : 4 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :

BECTA6 Bulletin of Environmental Contamination and Toxicology.


NJ





DOSE : 95 mg/kg

SEX/DURATION : lactating female 4 day(s) post-birth

TOXIC EFFECTS :


gain)

REFERENCE :



101,220,1989




DOSE : 71319 ug/kg


TOXIC EFFECTS :


gain)

REFERENCE :



101,220,1989




DOSE : 12 mg/kg


TOXIC EFFECTS :


before birth)

REFERENCE :



41,205,1977




DOSE : 8 mg/kg


TOXIC EFFECTS :


REFERENCE :



41,205,1977




DOSE : 16 mg/kg


TOXIC EFFECTS :



gain)

REFERENCE :



43,381,1978




DOSE : 2560 mg/kg


TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant

per # sperm positive females; # females pregnant per # females mated)



REFERENCE :







DOSE : 30 mg/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 20 mg/kg


TOXIC EFFECTS :






before birth)

REFERENCE :






DOSE : 20 mg/kg


TOXIC EFFECTS :



Reproductive - Specific Developmental Abnormalities - Central Nervous

System


abnormalities

REFERENCE :






DOSE : 5078 ug/kg


TOXIC EFFECTS :


REFERENCE :


(Alan






DOSE : 2649 ug/kg


TOXIC EFFECTS :




REFERENCE :


(Alan






DOSE : 875 mg/kg


TOXIC EFFECTS :


REFERENCE :



97,180,1982

** MUTATION DATA **




REFERENCE :






REFERENCE :







REFERENCE :



Calcutta





REFERENCE :



Calcutta





REFERENCE :

FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29

Prague 1, Czechoslavakia) V.4- 1959- Volume(issue)/page/year:

28,17,1983





REFERENCE :



320,133,1994




REFERENCE :

CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,

USA,

1255 Howard St., San Francisco, CA 94103) V.6- 1958-




DOSE/DURATION : 1 mmol

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

1,21,1986




REFERENCE :

TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach

Science

Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-





REFERENCE :


Science






REFERENCE :


Science






REFERENCE :



198,115,1988





REFERENCE :

GWZHEW Gongye Weisheng Yu Zhiyebing. Industrial Health and Occupational

Diseases. (China International Book Trading Corp., POB 2820, Beijing,

Peop.

Rep. China) V.1- 1973- Volume(issue)/page/year: 12,77,1986


TEST SYSTEM : Rodent - mouse Fibroblast


REFERENCE :



47,2142,1987

TYPE OF TEST : Dominant lethal test




REFERENCE :



97,180,1982




REFERENCE :

TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,

Fairview

Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year:

2,303,1988




REFERENCE :

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.

Ireland


17,273,1983



TEST SYSTEM : Rodent - hamster


REFERENCE :

BLOAAO Biologia (Bratislava). (PNS-Ustredna Expedicia a Dovoz Tlace,

Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.8- 1953-





REFERENCE :



45,2320,1985




REFERENCE :






REFERENCE :



217,65,1989




REFERENCE :


Science





TEST SYSTEM : Rodent - hamster


REFERENCE :

BLOAAO Biologia (Bratislava). (PNS-Ustredna Expedicia a Dovoz Tlace,

Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.8- 1953-


*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)


TOXICOLOGY REVIEW



3,156,1973

TOXICOLOGY REVIEW









3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994







1993




1993

















REFERENCE :













EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion

EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay


NICKEL(II) CHLORIDE HEXAHYDRATE


CHEMICAL NAME : Nickel(II) chloride, hexahydrate (1:2:6)




MOLECULAR FORMULA : Cl2-Ni.6H2-O


WISWESSER LINE NOTATION : NI G2 &QH 6


Mutagen








TOXIC EFFECTS :


specified



REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation).

Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,

Surrey,

UK) V.30- 1967- Volume(issue)/page/year: 32,102,1969





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Rep.







TOXIC EFFECTS :

Gastrointestinal - alteration in gastric secretion


Nutritional and Gross Metabolic - changes in metals, not otherwise specified

REFERENCE :

RPTOAN Russian Pharmacology and Toxicology (English Translation).

Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,

Surrey,

UK) V.30- 1967- Volume(issue)/page/year: 32,102,1969





TOXIC EFFECTS :

Brain and Coverings - other degenerative changes



excretion)

REFERENCE :



3,369,1979





DOSE : 1670 mg/kg

SEX/DURATION : female 11 day(s) after conception - 1 day(s)

post-birth

TOXIC EFFECTS :


4

per # born alive)

REFERENCE :



** MUTATION DATA **




REFERENCE :








REFERENCE :



394,133,1997




REFERENCE :



68,337,1979




REFERENCE :



261,131,1991




REFERENCE :



104,141,1982

*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)







3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994







1993




1993

















REFERENCE :














NICKEL(II) FLUORIDE


CHEMICAL NAME : Nickel(II) fluoride (1:2)




MOLECULAR FORMULA : F2-Ni


WISWESSER LINE NOTATION : NI F2



* Nickel difluoride

* Nickelous fluoride


** MUTATION DATA **




DOSE/DURATION : 4 mg/kg/24H (Intermittent)

REFERENCE :



Calcutta






REFERENCE :



Calcutta






REFERENCE :



Calcutta






REFERENCE :



Calcutta


TYPE OF TEST : Sperm Morphology



DOSE/DURATION : 4 mg/kg/4D (Intermittent)

REFERENCE :



Calcutta


*** REVIEWS ***





TLV/BEI,1997

ACGIH TLV-TWA 2.5 mg(F)/m3




TLV/BEI,1997

TOXICOLOGY REVIEW



3,156,1973

TOXICOLOGY REVIEW









3,178,1971



Supt.


29,1910.1000,1994

OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3


Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994

OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3


Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993

OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3


Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994

OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3


Supt.


41,50-204.50,1994



OEL-AUSTRIA: MAK 2.5 mg(F)/m3, JAN1999


OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993



OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993


OEL-POLAND: MAC(TWA) 1 mg(HF)/m3, MAC(STEL) 3 mg(HF)/m3, JAN1999


1993

OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993

OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993



1993

OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993




OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993


OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993



OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993



OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993


OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993

OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993



OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993






REFERENCE :



















NICKEL(II) NITRATE HEXAHYDRATE


CHEMICAL NAME : Nickel(II) nitrate (1:2)




MOLECULAR FORMULA : N2-O6.Ni


WISWESSER LINE NOTATION : NI N-O3*2




* Nickel bis(nitrate)

* Nickel dinitrate

* Nickelous nitrate

* Nitric acid, nickel(II) salt







TOXIC EFFECTS :




REFERENCE :






ROUTE OF EXPOSURE : Intratesticular


DOSE : 14618 ug/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-





DOSE : 14618 ug/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,

sperm morphology, motility, and count)


REFERENCE :


Depot,






DOSE : 1960 mg/kg


TOXIC EFFECTS :


REFERENCE :



97,180,1982

** MUTATION DATA **





REFERENCE :



97,180,1982

*** REVIEWS ***





TLV/BEI,1997






3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994







1993




1993

















REFERENCE :




















NICKEL(II) NITRATE HEXAHYDRATE


CHEMICAL NAME : Nickel(II) nitrate, hexahydrate (1:2:6)




MOLECULAR FORMULA : N2-O6.Ni.6H2-O


WISWESSER LINE NOTATION : NI N-O3*2 &QH 6



* Nitric acid, nickel(2+) salt, hexahydrate

* Nickel dinitrate hexahydrate

* Nickel(2+) dinitrate hexahydrate

* Nickel(2+) nitrate, hexahydrate

* Nickelous nitrate hexahydrate







TOXIC EFFECTS :


REFERENCE :



30,470,1969

*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)







3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994







1993




1993

















REFERENCE :




NICKEL(II) OXIDE


CHEMICAL NAME : Nickel(II) oxide (1:1)




MOLECULAR FORMULA : Ni-O


WISWESSER LINE NOTATION : NI O


Mutagen

Natural Product


* Black nickel oxide

* Bunsenite

* C.I. 77777

* Green nickel oxide

* Mononickel oxide

* Nickel monoxide

* Nickelous oxide

* Nickel oxide sinter 75

* Nickel protoxide







TOXIC EFFECTS :


REFERENCE :

FDRLI* Food & Drug Research Laboratories, Inc., Papers. (P.O. Box 107,

Rt.

17C, Waverly, NY 14892-0107) Volume(issue)/page/year: 7684B,1983





TOXIC EFFECTS :


REFERENCE :



Volume(issue)/page/year: AEC-TR-6710





TOXIC EFFECTS :


REFERENCE :

ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I.

Mendeleeva.

Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O







TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :


Rep.







TOXIC EFFECTS :





REFERENCE :







TOXIC EFFECTS :



REFERENCE :






DOSE/DURATION : 200 mg/m3/24H/4W-C

TOXIC EFFECTS :


Immunological Including Allergic - decrease in humoral immune response

REFERENCE :

EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1

E.


8,516,1984




DOSE/DURATION : 25 mg/m3/24H/4W-C

TOXIC EFFECTS :



REFERENCE :

EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1

E.


8,516,1984





TOXIC EFFECTS :





REFERENCE :

DTESD7 Developments in Toxicology and Environtal Science. (Elsevier

Science, New York, NY) V.1-15, 1977-87. Discontinued






TOXIC EFFECTS :



Immunological Including Allergic - increase in humoral immune response

REFERENCE :








TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : 1250 ug/m3/6H/2Y-I

TOXIC EFFECTS :



REFERENCE :



NTP-TR-451,1996





TOXIC EFFECTS :




REFERENCE :


Ave.,






TOXIC EFFECTS :



REFERENCE :

55DXAE "Progress in Nickel Toxicology, Proceedings of the International

Conference on Nickel Metabolism and Toxicology, 3rd, 1984," Brown, S.S., and

F.W. Sunderman, Jr., eds., Oxford, UK, Blackwell Scientific Pub. Ltd.,

1985






TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :



REFERENCE :


(Waverly






DOSE/DURATION : 5 mg/m3/6H/2Y-I

TOXIC EFFECTS :



REFERENCE :



NTP-TR-451,1996





TOXIC EFFECTS :



REFERENCE :



22,158,1962





TOXIC EFFECTS :




REFERENCE :



22,158,1962

** MUTATION DATA **




REFERENCE :



47,3815,1987




REFERENCE :



300,179,1993




REFERENCE :


(Waverly






REFERENCE :


Ave.,


*** REVIEWS ***

ACGIH TLV-TWA 1 mg(Ni)/m3




TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)


TOXICOLOGY REVIEW



3,156,1973

TOXICOLOGY REVIEW


For


TOXICOLOGY REVIEW




TOXICOLOGY REVIEW

DICHAK Diseases of the Chest. (Chicago, IL) V.1-56, 1935-69. For

publisher information, see CHETBF. Volume(issue)/page/year: 54,527,1968






3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994








1993




1993






OEL-SWEDEN:TWA 0.1 mg/m3;Carcinogen JAN 1993












REFERENCE :





















NTP Carcinogenesis studies (inhalation);some evidence:rat



NTP-TR-451,1996

NTP Carcinogenesis studies (inhalation);equivocal evidence:mouse



NTP-TR-451,1996


Human Carcinogen

NICKEL(II) PERCHLORATE HEXAHYDRATE

RTECS NUMBER : SC9550000

CHEMICAL NAME : Perchloric acid, nickel(2+) salt, hexahydrate




MOLECULAR FORMULA : Cl2-O8.Ni.6H2-O


WISWESSER LINE NOTATION : NI G-O4*2 &QH 6


* Nickel diperchlorate hexahydrate

* Nickel(2+) perchlorate, hexahydrate

* Nickelous perchlorate hexahydrate







TOXIC EFFECTS :


REFERENCE :

JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical

Soc.,

Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC


*** REVIEWS ***





TLV/BEI,1997






3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994







1993




1993

















REFERENCE :




NICKEL(II) TETRAFLUOROBORATE


CHEMICAL NAME : Nickel(II) fluoborate




MOLECULAR FORMULA : B2-F8.Ni


WISWESSER LINE NOTATION : .NI..B-F4



* Borate(1-), tetrafluoro-, nickel(2+) (2:1)

* Nickel borofluoride

* Nickel fluoroborate

* Nickelous tetrafluoroborate

* Nickel(II) tetrafluoroborate

* TL 1091







TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : 530 mg/m3/10M

TOXIC EFFECTS :


REFERENCE :

NDRC** National Defense Research Committee, Office of Scientific Research

and Development, Progress Report. Volume(issue)/page/year:

No.9-4-1-19,1943

*** REVIEWS ***





TLV/BEI,1997






3,178,1971



Supt.


29,1910.1000,1994



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994



Supt.


41,50-204.50,1994







1993




1993

















REFERENCE :




















NICOTINAMIDE ADENINE DINUCLEOTIDE

RTECS NUMBER : UU3450000

CHEMICAL NAME : Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-,

hydroxide, 5'-ester with adenosine 5'-

5'-(trihydrogen pyrophosphate), inner salt






MOLECULAR FORMULA : C21-H27-N7-O14-P2


WISWESSER LINE NOTATION : T56 BN DN GN INJ FZ B- BT5OJ CQ DQ E1OPWOPWO1-

BT5OTJ

CQ DQ E- AT6KJ CVZ



* Adenine-nicotinamide dinucleotide

* Codehydrase I

* Codehydrogenase I

* Coenzyme I

* Cozymase

* Cozymase I

* Diphosphopyridine nucleotide

* DPN

* Enzopride

* NAD

* NAD+

* beta-Nad

* Nadide

* Nicotinamide-adenine dinucleotide

* Nicotineamide adenine dinucleotide







TOXIC EFFECTS :


REFERENCE :


Translation



** MUTATION DATA **




REFERENCE :


5050,




















NICOTINE


CHEMICAL NAME : Nicotine, (+-)-






MOLECULAR FORMULA : C10-H14-N2



* (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine

* (+-)-Nicotine

* dl-beta-Nicotine

* DL-Nicotine

* (R,S)-Nicotine

* Pyridine, 3-(1-methyl-2-pyrrolidinyl)-

* Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (+-)-







TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :


&



NICOTINE


CHEMICAL NAME : Nicotine



16760-37-5



MOLECULAR FORMULA : C10-H14-N2


WISWESSER LINE NOTATION : T6NJ C- BT5NTJ A1


Mutagen


Human

Natural Product


* Black leaf

* Destruxol orchid spray

* Emo-nik

* ENT 3,424

* Flux MAAG

* Fumetobac

* Mach-Nic

* 1-Methyl-2-(3-pyridyl)pyrrolidine

* 3-(N-Methylpyrrolidino)pyridine

* (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine

* L-3-(1-Methyl-2-pyrrolidyl)pyridine

* (-)-3-(1-Methyl-2-pyrrolidyl)pyridine

* Niagara P.A. dust

* Nicocide

* Nico-dust

* Nico-fume

* Nicotina

* (-)-Nicotine

* l-Nicotine

* L-Nicotine

* (S)-Nicotine

* Nicotine

* Nicotine alkaloid

* Nikotin

* Nikotyna

* Ortho N-4 dust

* Ortho N-5 dust

* Ortho N-4 and N-5 dusts

* Pyridine, 3-(1-methyl-2-pyrrolidinyl)-

* Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-

* Pyridine, 3-(tetrahydro-1-methylpyrrol-2-yl)

* beta-Pyridyl-alpha-N-methylpyrrolidine

* Pyrrolidine, 1-methyl-2-(3-pyridal)-

* RCRA waste number P075

* Tendust

* Tetrahydronicotyrine, dl-

* XL all insecticide







TOXIC EFFECTS :


REFERENCE :


J.M.,



ROUTE OF EXPOSURE : Rectal



TOXIC EFFECTS :



REFERENCE :

CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher

information, see JTCTDW. Volume(issue)/page/year: 10,391,1977





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.

Discontinued. Volume(issue)/page/year: 9,119,1970





TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :



1939- Volume(issue)/page/year: 47(5),85,1984





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :




Behavioral - ataxia

REFERENCE :

SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H


127,1054,1958





TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :

ARDSBL American Review of Respiratory Disease. (American Lung Assoc.,

1740

Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:

129,112,1984


ROUTE OF EXPOSURE : Intraduodenal



TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Behavioral - tremor



REFERENCE :

HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.

(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:

34(4-6),187,1969





TOXIC EFFECTS :


REFERENCE :



28,227,1974





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Behavioral - tremor



REFERENCE :

BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd.,

Houndmills,



35,161,1969





TOXIC EFFECTS :




Behavioral - ataxia

REFERENCE :



127,1054,1958





TOXIC EFFECTS :


REFERENCE :

EPXXDW European Patent Application. (U.S. Patent and Trademark Office,

Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0000106





TOXIC EFFECTS :


REFERENCE :



1903/04-






TOXIC EFFECTS :


REFERENCE :

FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"

Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg,

Fed.

Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931





TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :



1903/04-






TOXIC EFFECTS :


REFERENCE :



1903/04-






TOXIC EFFECTS :




Behavioral - ataxia

REFERENCE :



127,1054,1958





TOXIC EFFECTS :


REFERENCE :



Fed.






TOXIC EFFECTS :


REFERENCE :



1903/04-






TOXIC EFFECTS :




Behavioral - ataxia

REFERENCE :



127,1054,1958





TOXIC EFFECTS :



REFERENCE :

AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the

United States. (Denver, CO) V.3-38, 1939-74. Volume(issue)/page/year:

16,3,1952





TOXIC EFFECTS :


REFERENCE :



1903/04-






TOXIC EFFECTS :


REFERENCE :



Fed.






TOXIC EFFECTS :


REFERENCE :



1903/04-






TOXIC EFFECTS :




Behavioral - ataxia

REFERENCE :



127,1054,1958



SPECIES OBSERVED : Mammal - pig


TOXIC EFFECTS :


Behavioral - excitement


REFERENCE :



127,1054,1958





TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




Behavioral - ataxia

REFERENCE :



127,1054,1958



SPECIES OBSERVED : Bird - pigeon


TOXIC EFFECTS :


REFERENCE :



Fed.






TOXIC EFFECTS :




Behavioral - ataxia

REFERENCE :



127,1054,1958



SPECIES OBSERVED : Amphibian - frog


TOXIC EFFECTS :


REFERENCE :



Fed.






TOXIC EFFECTS :


REFERENCE :

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,

Springer-Verlag

New York, Inc., 1971 Volume(issue)/page/year: -,406,1971



SPECIES OBSERVED : Mammal - horse, donkey


TOXIC EFFECTS :



Behavioral - ataxia

REFERENCE :



127,1054,1958



SPECIES OBSERVED : Mammal - cattle


TOXIC EFFECTS :



Behavioral - ataxia

REFERENCE :



127,1054,1958



SPECIES OBSERVED : Mammal - horse, donkey


TOXIC EFFECTS :



Behavioral - ataxia

REFERENCE :



127,1054,1958





TOXIC EFFECTS :


REFERENCE :



NJ




SPECIES OBSERVED : Bird - domestic


TOXIC EFFECTS :


REFERENCE :

PHZOA9 Physiological Zoology. (Univ. of Chicago Press, Journals Div.,

POB


12,238,1939






TOXIC EFFECTS :




REFERENCE :

IJEBA6 Indian Journal of Experimental Biology. (Publications &

Information

Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-






TOXIC EFFECTS :


Immunological Including Allergic - decrease in cellular immune response

REFERENCE :



135,268,1995





TOXIC EFFECTS :




excretion)

REFERENCE :



31,23,1986





DOSE : 40 ug/kg

SEX/DURATION : female 24 week(s) after conception

TOXIC EFFECTS :



REFERENCE :

BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell

Scientific

Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year:

90,710,1983




DOSE : 59400 ug/kg


TOXIC EFFECTS :


gain)

Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :



1903/04-





DOSE : 594 mg/kg



TOXIC EFFECTS :


REFERENCE :

NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80.

For

publisher information, see NTOTDY. Volume(issue)/page/year: 1,221,1979




DOSE : 22 mg/kg


TOXIC EFFECTS :


gain)

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell

House,



9,95,1987




DOSE : 319 mg/kg


lactating female 35 day(s) post-birth

TOXIC EFFECTS :


REFERENCE :

BRREAP Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE


732,257,1996




DOSE : 5250 ug/kg


TOXIC EFFECTS :



Reproductive - Specific Developmental Abnormalities - skin and skin

appendages


REFERENCE :

ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28,

Prague

1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 15,148,1973




DOSE : 102 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects


REFERENCE :

DBRRDB Developmental Brain Research. (Elsevier Science Pub. B.V., POB

211,

1000 AE Amsterdam, Netherlands) V.1- 1981- Volume(issue)/page/year:

102,117,1997




DOSE : 8800 ug/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - physical

REFERENCE :







DOSE : 33 mg/kg


TOXIC EFFECTS :


4

per # born alive)

REFERENCE :







DOSE : 40 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition




REFERENCE :


(Alan


Volume(issue)/page/year: 23,53A,1981




DOSE : 9 mg/kg


TOXIC EFFECTS :


REFERENCE :

BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New





DOSE : 32 mg/kg


TOXIC EFFECTS :



REFERENCE :

ENDKAC Endokrinologie. (Leipzig, Ger. Dem. Rep.) V.1-80, 1928-82. For

publisher information, see EXCEDS. Volume(issue)/page/year: 69,359,1977




DOSE : 22500 ug/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - postpartum


gain)

REFERENCE :

AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,

11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-





DOSE : 12 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system


gain)

Reproductive - Effects on Newborn - delayed effects

REFERENCE :


(Alan


Volume(issue)/page/year: 25(2),77A,1982




DOSE : 126 mg/kg


TOXIC EFFECTS :



4

per # born alive)


gain)

REFERENCE :







DOSE : 126 mg/kg


TOXIC EFFECTS :





REFERENCE :







DOSE : 60 mg/kg


TOXIC EFFECTS :


REFERENCE :

BIRSB5 Biology of Reproduction, Supplement. (Champaign, IL) No.1-4,

1969-71(?). Discontinued. For publisher information, see BIREBV.

Volume(issue)/page/year: 20(Suppl 1),52A,1979




DOSE : 125 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial

(including nose and tongue)


REFERENCE :

ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,

Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886- Volume(issue)/page/year:

168,109,1989




DOSE : 125 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear




REFERENCE :



172,257,1991




DOSE : 125 mg/kg


TOXIC EFFECTS :



Reproductive - Specific Developmental Abnormalities - respiratory system

REFERENCE :



172,257,1991




DOSE : 7 mg/kg


TOXIC EFFECTS :



REFERENCE :






DOSE : 19200 ug/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - germ cell effects (in offspring)

REFERENCE :






DOSE : 5750 ug/kg



TOXIC EFFECTS :



REFERENCE :

BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New





DOSE : 37 mg/kg



TOXIC EFFECTS :


REFERENCE :

SAMJAF South African Medical Journal. (Medical Assoc. of South Africa,

Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-





DOSE : 16 mg/kg


TOXIC EFFECTS :



REFERENCE :


(Alan






DOSE : 642 mg/kg


female 1-21 day(s) after conception

TOXIC EFFECTS :



REFERENCE :



66,30,1982




DOSE : 16 mg/kg


TOXIC EFFECTS :




REFERENCE :

SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o

Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,

Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher

information, see CGANE7. Volume(issue)/page/year: 16,253,1976




DOSE : 24 mg/kg


TOXIC EFFECTS :




appendages

REFERENCE :








DOSE : 24 mg/kg


TOXIC EFFECTS :





REFERENCE :



127,877,1958




DOSE : 1 mg/kg


TOXIC EFFECTS :





REFERENCE :


(Alan






DOSE : 1 mg/kg


TOXIC EFFECTS :


gain)

REFERENCE :


(Alan






DOSE : 25 mg/kg


TOXIC EFFECTS :





REFERENCE :



127,877,1958




DOSE : 25 mg/kg


TOXIC EFFECTS :


before birth)

REFERENCE :



127,877,1958




DOSE : 50 mg/kg


TOXIC EFFECTS :






REFERENCE :

KAIZAN Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o

Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1-

1928-





DOSE : 500 ug/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 408 mg/kg


TOXIC EFFECTS :


REFERENCE :

NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)

V.3-8,

1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:

4,365,1982




DOSE : 408 mg/kg


TOXIC EFFECTS :


gain)

REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 193,159,1979




DOSE : 200 ug/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 13 mg/kg

SEX/DURATION : female 3-19 week(s) after conception

TOXIC EFFECTS :




REFERENCE :

AJPEEK American Journal of Perinatology. (Thieme Medical Publishers,

Inc.

381 Park Ave. S., New York, NY 10157-0208) V.1- 1983-


** MUTATION DATA **




REFERENCE :

RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione

Umana. Review of Science and Technology of Food and Human Nutrition.

(Bologna, Italy) V.5-6, 1975-76. Discontinued.


6,161,1976




REFERENCE :


Ireland


33,91,1986




REFERENCE :


Ireland


33,91,1986




DOSE/DURATION : 10 mg/kg/2D (Intermittent)

REFERENCE :

IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK)

V.3-11,

1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year:

6,461,1978




REFERENCE :


Ireland


54,89,1990




REFERENCE :


Ireland


54,89,1990


TEST SYSTEM : Rodent - rabbit Cells - not otherwise specified


REFERENCE :



*** REVIEWS ***

ACGIH TLV-TWA 0.5 mg/m3 (skin)




TLV/BEI,1997

TOXICOLOGY REVIEW

CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby

Co.,



TOXICOLOGY REVIEW

CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for

Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-


TOXICOLOGY REVIEW

ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For

publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

TOXICOLOGY REVIEW

FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub

lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973





54,7740,1989

MSHA STANDARD-air:TWA 0.5 mg/m3 (skin)




3,181,1971

OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin)


Supt.


29,1910.1000,1994

OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin)


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin)


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin)


Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin JAN 1993

OEL-AUSTRIA: MAK 0.07 ppm (0.2 mg/m3), JAN1999

OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin JAN 1993

OEL-BELGIUM:TWA 0.5 mg/m3;Skin JAN 1993

OEL-DENMARK: TWA 0.5 mg/m3, Skin, JAN1999

OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993

OEL-GERMANY:TWA 0.07 ppm (0.5 mg/m3);Skin JAN 1993

OEL-HUNGARY:STEL 0.5 mg/m3;Skin JAN 1993

OEL-THE NETHERLANDS:TWA 0.07 ppm (0.5 mg/m3);Skin JAN 1993

OEL-POLAND: MAC(TWA) 0.5 mg/m3, MAC(STEL) 1.5 mg/m3, JAN1999

OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993

OEL-SWITZERLAND:TWA 0.07 ppm (0.5 mg/m3);STEL 0.14 ppm;Skin JAN 1993

OEL-THAILAND:TWA 0.5 mg/m3 JAN 1993

OEL-TURKEY:TWA 0.5 mg/m3;Skin JAN 1993

OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993





NIOSH REL TO NICOTINE-air:10H TWA 0.5 mg/m3 (Sk)

REFERENCE :



















EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine

reversion-Ames test


NIOSH Analytical Method, 1994: Nicotine, 2544

NICOTINE HEMISULFATE


CHEMICAL NAME : Nicotine, sulfate (2:1)




MOLECULAR FORMULA : C20-H28-N4.O4-S


WISWESSER LINE NOTATION : T6NJ C- BT5NTJ A1 &S-O4




* ENT 2,435

* l-1-Methyl-2-(3-pyridyl)-pyrrolidine sulfate

* (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine sulfate (2:1)

* l-3-(1-Methyl-2-pyrrolidyl)pyridine sulfate

* Nicotine sulfate

* Nikotinsulfat

* Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, sulfate (2:1)

* Pyrrolidine, 1-methyl-2-(3-pyridyl)-, sulfate

* Sulfate de nicotine







TOXIC EFFECTS :


REFERENCE :

ARSIM* Agricultural Research Service, USDA Information Memorandum.

(Beltsville, MD 20705) Volume(issue)/page/year: 20,16,1966




DOSE/DURATION : 22 mg/m3

TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :

Behavioral - tremor



REFERENCE :



2,88,1960

TYPE OF TEST : LD90 - Lethal Dose




TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :

NURIBL Nutrition Reports International. (Geron-X, Inc., POB 1108, Los

Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 23,43,1981





TOXIC EFFECTS :

Behavioral - tremor



REFERENCE :



34(4-6),187,1969





TOXIC EFFECTS :


REFERENCE :

JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of

Great

Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-






TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :

85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer

Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R.,

Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 Volume(issue)/page/year:

-,141,1971





TOXIC EFFECTS :


REFERENCE :



21,315,1972



SPECIES OBSERVED : Bird - quail


TOXIC EFFECTS :


REFERENCE :



NJ




SPECIES OBSERVED : Bird - duck


TOXIC EFFECTS :


REFERENCE :



21,315,1972





TOXIC EFFECTS :


REFERENCE :



21,315,1972






TOXIC EFFECTS :


REFERENCE :








DOSE : 1670 mg/kg


TOXIC EFFECTS :






REFERENCE :

BSTME2 Biological Structures and Morphogenesis. (Paris, Francs) V.1-

1988-

Volume(issue)/page/year: 3,31,1990/1991





54,7740,1989







NICOTINIC ACID

RTECS NUMBER : QT0525000

CHEMICAL NAME : Nicotinic acid








WISWESSER LINE NOTATION : T6NJ CVQ


Drug

Human


* Acide nicotinique

* Acidum nicotinicum

* Akotin

* Anti-pellagra vitamin

* Apelagrin

* Bionic

* 3-Carboxypyridine

* Daskil

* Davitamon PP

* Direktan

* Efacin

* Kyselina nikotinova

* NAH

* Niacin

* Nicacid

* Nicangin

* NICO

* Nico-400

* Nicobid

* Nicocap

* Nicocidin

* Nicocrisina

* Nicodan

* Nicodelmine

* Nicolar

* Niconacid

* Niconat

* Niconazid

* Nicosan 3

* Nico-span

* Nicosyl

* Nicotamin

* Nicotene

* Nicotil

* Nicotine acid

* Nicotinipca

* Nicotinoylhydrazine

* Nicotinsaure

* Nicovasan

* Nicovasen

* Nicyl

* Nipellen

* Pellagramin

* Pellagra preventive factor

* Pellagrin

* Pelonin

* Peviton

* PP factor

* P.P. factor-pellagra preventive factor

* Pyridine-3-carbonic acid

* Pyridine-beta-carboxylic acid

* Pyridine-3-carboxylic acid

* 3-Pyridinecarboxylic acid

* Pyridine-carboxylique-3

* S115

* SK-Niacin

* SR 4390

* Tinic

* Vitaplex N

* Wampocap







TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - visual field changes

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :

JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.

Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:

279,1702,1998





TOXIC EFFECTS :

Blood - change in clotting factors

Blood - changes in platelet count

REFERENCE :


Chicago,






TOXIC EFFECTS :



Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :

SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :



1903/04-






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :



REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,

France) V.1- 1946- Volume(issue)/page/year: 26,831,1971





TOXIC EFFECTS :


REFERENCE :

BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office,

Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041937





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :



1903/04-







TOXIC EFFECTS :



REFERENCE :

ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland)

V.21-






















NIFEDIPINE

RTECS NUMBER : US7975000

CHEMICAL NAME : 3,5-Pyridinedicarboxylic acid,

1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl

ester



101554-38-5







WISWESSER LINE NOTATION : T6M DHJ B1 CVO1 DR BNW& EVO1 F1



Human


* Adalat

* Adalate

* BAY 1040

* BAY A 1040

* Citilat

* Corinfar

* 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid

dimethyl ester

* Dimethyl

1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylate

* Fenihidin

* Fenihidine

* Nifedipine

* 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine

*

4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredim

ethylester

* Oxcord

* Procardia







TOXIC EFFECTS :

Immunological Including Allergic - anaphylaxis

REFERENCE :


Chicago,






TOXIC EFFECTS :



Gastrointestinal - necrotic changes

REFERENCE :

JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270

Madison Ave., New York, NY 10016) V.19- 1982-


33,725,1995





TOXIC EFFECTS :


specified

REFERENCE :






DOSE/DURATION : 2400 ug/kg/3D-I

TOXIC EFFECTS :

Behavioral - toxic psychosis

REFERENCE :




304,1225,1992





TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section


REFERENCE :

JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,

2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-






TOXIC EFFECTS :



Nutritional and Gross Metabolic - body temperature increase

REFERENCE :

AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline

Industrial

Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year:

108,611,1984





TOXIC EFFECTS :

Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)

Behavioral - headache


REFERENCE :

PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd.,

POB

88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 62,1029,1986





TOXIC EFFECTS :


Behavioral - toxic psychosis

REFERENCE :

AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave.,

New





DOSE/DURATION : 600 ug/kg/45M-I

TOXIC EFFECTS :



REFERENCE :


Chicago,






TOXIC EFFECTS :

Cardiac - change in rate


REFERENCE :

HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel

Road,

Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-





DOSE/DURATION : 143 ug/kg/1D

TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Cardiac - cardiomyopathy including infarction



REFERENCE :

PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,

Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 86,91,1990





TOXIC EFFECTS :

Cardiac - change in rate


REFERENCE :

AEMED3 Annals of Emergency Medicine. (American College of Emergency

Physicians, 1125 Executive Circle, Irving, TX 75038)






TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Tokyo,






TOXIC EFFECTS :



Behavioral - ataxia

REFERENCE :

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda

Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-






TOXIC EFFECTS :


REFERENCE :


D-1000


54,275,1983





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :



REFERENCE :


Translation







TOXIC EFFECTS :



Behavioral - ataxia

REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :



Nutritional and Gross Metabolic - changes in potassium

REFERENCE :








TOXIC EFFECTS :



Nutritional and Gross Metabolic - changes in potassium

REFERENCE :








TOXIC EFFECTS :

Cardiac - changes in heart weight




REFERENCE :








TOXIC EFFECTS :



REFERENCE :



36(1,pt2),174,1997





DOSE : 200 ug/kg


TOXIC EFFECTS :



REFERENCE :

GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc.,

79

Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year:

24,151,1987




DOSE : 200 ug/kg


TOXIC EFFECTS :



REFERENCE :

BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell

Scientific

Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year:

100,959,1993




DOSE : 550 mg/kg


TOXIC EFFECTS :



REFERENCE :

YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu

Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-





DOSE : 10 mg/kg


TOXIC EFFECTS :



REFERENCE :

PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,

Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 26,442,1989




DOSE : 40 mg/kg


TOXIC EFFECTS :


REFERENCE :



40,127,1988




DOSE : 275 mg/kg


TOXIC EFFECTS :






REFERENCE :



Volume(issue)/page/year: 21(Suppl 4),S1095,1993




DOSE : 15 mg/kg


TOXIC EFFECTS :





REFERENCE :

REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,



11,207,1997




DOSE : 5 gm/kg


TOXIC EFFECTS :





REFERENCE :







DOSE : 33200 ug/kg


TOXIC EFFECTS :


REFERENCE :


(Alan






DOSE : 780 mg/kg


TOXIC EFFECTS :





REFERENCE :







DOSE : 6 mg/kg


TOXIC EFFECTS :


REFERENCE :

YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical

Journal.

(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.

China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:

21,740,1986




DOSE : 6 mg/kg


TOXIC EFFECTS :


REFERENCE :

YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical

Journal.

(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.

China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:

21,740,1986




DOSE : 94 ug/kg/30M-C


TOXIC EFFECTS :




REFERENCE :













NILE BLUE

RTECS NUMBER : DJ1931000

CHEMICAL NAME : Benzo(a)phenoxazin-7-ium,

5-amino-9-(diethylamino)-,

sulfate (2:1)




MOLECULAR FORMULA : C40-H40-N6-O2.O4-S


WISWESSER LINE NOTATION : T D6 B666 CN JOJ GN2&2 MZ 2 &.S-O4 &15/33


* 5H-Benzo(a)phenazoxazine, 9-(diethylamino)-5-imino-, sulfate (2:1)

* Nile Blue A sulfate

* Nile Blue sulfate







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :



44,225,1978










NILE BLUE CHLORIDE

RTECS NUMBER : DJ1930000

CHEMICAL NAME : Benzo(a)phenoxazin-7-ium,

5-amino-9-(diethylamino)-,

chloride





MOLECULAR FORMULA : C20-H20-N3-O.Cl


WISWESSER LINE NOTATION : T D6 B666 CN JOJ GN2&2 MZ &G &15/28



* 5H-Benzo(a)phenazoxazine, 9-diethylamino-5-imino-, hydrochloride

* Benzo(a)phenazoxonium, 5-amino-9-(diethylamino)-, chloride

* C.I. 51180

* C.I. Basic Blue 12

* Cresol Fast Violet

* Cresyl Fast Violet

* Nile Blue

* Nile Blue A

* Nile Blue AX

* Nile Blue Base

* Nile Blue chloride

* Nile Blue hydrochloride







TOXIC EFFECTS :


REFERENCE :



44,225,1978

** MUTATION DATA **




REFERENCE :

POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of

Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State

Univ., Weatherford, OK 73096) V.1- 1910/1920-


34,114,1953












NINHYDRIN

RTECS NUMBER : NK5425000

CHEMICAL NAME : 1,3-Indandione, 2,2-dihydroxy-








WISWESSER LINE NOTATION : L56 BV DV CHJ CQ CQ



* 2,2-Dihydroxy-1,3-indandione

* 2,2-Dihydroxy-1H-indene-1,3(2H)-dione

* 1,2,3-Indantrione, 2-hydrate

* 1,2,3-Indantrione monohydrate

* Ninhydrin

* Ninhydrin hydrate

* Triketohydrindene hydrate







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :

CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses

Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-



















NIOBIUM

RTECS NUMBER : QT9900000

CHEMICAL NAME : Niobium




MOLECULAR FORMULA : Nb



* Columbium

* Niobium-93

* Niobium element

* VN 1







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :

















NIOBIUM(V) CHLORIDE

RTECS NUMBER : QU0350000

CHEMICAL NAME : Niobium chloride




MOLECULAR FORMULA : Cl5-Nb


WISWESSER LINE NOTATION : NB G5



* Columbium pentachloride

* Niobium pentachloride







TOXIC EFFECTS :


REFERENCE :



31(7-9),328,1966





TOXIC EFFECTS :


REFERENCE :


Rep.






TOXIC EFFECTS :


REFERENCE :



31(7-9),328,1966





TOXIC EFFECTS :




REFERENCE :



4,385,1962






TOXIC EFFECTS :


REFERENCE :



4,385,1962


EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay



NISOLDIPINE

RTECS NUMBER : US7975600

CHEMICAL NAME : 3,5-Pyridinedicarboxylic acid,

1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl

2-methyl propyl ester









* BAY-k 5552

* Nisoldipine







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :

IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho

Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-

1970-






TOXIC EFFECTS :


REFERENCE :

NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2,

1983-84. For publisher information, see NCDREP.


1,243,1983





TOXIC EFFECTS :


REFERENCE :




1,243,1983





TOXIC EFFECTS :


REFERENCE :




1,243,1983

NITRIC ACID

RTECS NUMBER : QU5775000

CHEMICAL NAME : Nitric acid




MOLECULAR FORMULA : H-N-O3


WISWESSER LINE NOTATION : H N-O3



Human


* Acide nitrique

* Acido nitrico

* Aqua fortis

* Azotic acid

* Azotowy kwas

* Hydrogen nitrate

* Kyselina dusicne

* Nitric acid

* Salpetersaure

* Salpeterzuuroplossingen







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


J.M.,






DOSE/DURATION : 1071 ug/m3/24H/84D-C

TOXIC EFFECTS :




levels - true cholinesterase

REFERENCE :








TOXIC EFFECTS :


REFERENCE :

INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &

Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1-

1989-






DOSE : 21150 mg/kg


TOXIC EFFECTS :



REFERENCE :

ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB

Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.

Rep.) V.1- 1955- Volume(issue)/page/year: 29,667,1983




DOSE : 2345 mg/kg


TOXIC EFFECTS :


REFERENCE :

ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB

Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.

Rep.) V.1- 1955- Volume(issue)/page/year: 29,667,1983

*** REVIEWS ***

ACGIH TLV-STEL 10 mg/m3 (4 ppm)




TLV/BEI,1997

ACGIH TLV-TWA 5.2 mg/m3 (2 ppm)




TLV/BEI,1997

TOXICOLOGY REVIEW

ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671,

Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year:

35,165,1975

TOXICOLOGY REVIEW


D-1000


39,299,1978






3,181,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 2 ppm (5 mg/m3) JAN 1993


OEL-AUSTRALIA:TWA 2 ppm (5 mg/m3);STEL 4 ppm (10 mg/m3) JAN 1993

OEL-BELGIUM:TWA 2 ppm (5.2 mg/m3);STEL 4 ppm (10 mg/m3) JAN 1993


OEL-FINLAND:TWA 2 ppm (5 mg/m3);STEL 5 ppm (13 mg/m3);Skin JAN 1993

OEL-JAPAN: OEL 2 ppm (5.2 mg/m3), JAN1999


OEL-HUNGARY:STEL 5 mg/m3 JAN 1993


OEL-JAPAN:TWA 2 ppm (5.2 mg/m3) JAN 1993


OEL-RUSSIA:TWA 2 ppm;STEL 2 mg/m3;Skin JAN 1993

OEL-SWEDEN:TWA 2 ppm (5 mg/m3);STEL 5 ppm (13 mg/m3) JAN 1993

OEL-SWITZERLAND:TWA 2 ppm (5 mg/m3);STEL 4 ppm (10 mg/m3) JAN 1993

OEL-THAILAND:TWA 2 ppm (5 mg/m3) JAN 1993

OEL-TURKEY:TWA 2 ppm (5 mg/m3) JAN 1993






NIOSH REL TO NITRIC ACID-air:10H TWA 2 ppm;STEL 4 ppm

REFERENCE :



















EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE




NIOSH Analytical Method, 1994: Acids, inorganic, 7903

OSHA ANALYTICAL METHOD #ID-127

NITRILOTRIACETIC ACID

RTECS NUMBER : AJ0175000

CHEMICAL NAME : Acetic acid, nitrilotri-








WISWESSER LINE NOTATION : QV1N1VQ1VQ


Mutagen


* Aminotriacetic acid

* N,N-Bis(carboxymethyl)glycine

* CHEL 300

* Complexon I

* Glycine, N,N-bis(carboxymethyl)-

* Hampshire NTA acid

* Komplexon I

* Kyselina nitrilotrioctova

* NCI-C02766

* Nitrilotriacetic acid

* NTA

* Titriplex I

* Triglycine

* Triglycollamic acid

* Trilon A

* alpha,alpha',alpha''-Trimethylaminetricarboxylic acid

* Versene NTA acid







TOXIC EFFECTS :


REFERENCE :

ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub.,

Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962-






TOXIC EFFECTS :


REFERENCE :

NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to

the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)

Volume(issue)/page/year: NCI-E-C-72-3252,1973





TOXIC EFFECTS :


REFERENCE :


Corporate


20,83,1989






TOXIC EFFECTS :



REFERENCE :


House,



20,925,1982




DOSE/DURATION : 29439 ug/kg/4W-C

TOXIC EFFECTS :



Nutritional and Gross Metabolic - changes in calcium

REFERENCE :


For







TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :



REFERENCE :




** MUTATION DATA **




REFERENCE :



356,85,1996

*** REVIEWS ***



Chemicals


12210)


IARC Cancer Review:Human No Adequate Data


Chemicals


12210)




Chemicals


12210)



















EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal



NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat





Human Carcinogen

NITRILOTRIACETIC ACID

RTECS NUMBER : MB8400000

CHEMICAL NAME : Glycine, N,N-bis(carboxymethyl)-, trisodium salt




MOLECULAR FORMULA : C6-H6-N-O6.3Na


WISWESSER LINE NOTATION : QV1N1VQ1VQ


Mutagen



* Acetic acid, nitrilotri-, trisodium salt

* Cheelox nta-14, -Na3

* Hampshire NTA

* Nitrilotriacetic acid, trisodium salt

* Trisodium nitrilotriacetate

* Trisodium nitrilotriacetic acid







TOXIC EFFECTS :


REFERENCE :



18,398,1971





TOXIC EFFECTS :


REFERENCE :



18,398,1971





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :



18,398,1971





TOXIC EFFECTS :


REFERENCE :



18,398,1971






TOXIC EFFECTS :




REFERENCE :



18,398,1971





TOXIC EFFECTS :



REFERENCE :


House,



20,433,1982





TOXIC EFFECTS :


Nutritional and Gross Metabolic - changes in metals, not otherwise specified


REFERENCE :



21,244,1972






TOXIC EFFECTS :


Liver - tumors

Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :








DOSE : 39 gm/kg



TOXIC EFFECTS :


gain)

REFERENCE :


For





DOSE : 8 gm/kg



TOXIC EFFECTS :



REFERENCE :


For


** MUTATION DATA **





REFERENCE :



262,253,1991




REFERENCE :

JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,

Baffins

Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-





REFERENCE :


E.


12,21,1988




REFERENCE :



343,1,1995




REFERENCE :



343,1,1995




REFERENCE :



343,1,1995

*** REVIEWS ***



Chemicals


12210)




Chemicals


12210)






54,7740,1989




















NITRILOTRIACETIC ACID DISODIUM


CHEMICAL NAME : Acetic acid, nitrilotri-, disodium salt




MOLECULAR FORMULA : C6-H7-N-O6.2Na


WISWESSER LINE NOTATION : QV1N1VO&1VO &-NA- 2



* N,N-Bis(carboxymethyl)glycine disodium salt

* Disodium hydrogen nitrilotriacetate

* Disodium nitrilotriacetate

* Glycine, N,N-bis(carboxymethyl)-, disodium salt

* Kiresuto NTB

* Nitrilotriacetic acid, disodium salt







TOXIC EFFECTS :


REFERENCE :



18,398,1971

*** REVIEWS ***



Chemicals


12210)




Chemicals


12210)




NITRO BLUE TETRAZOLIUM CHLORIDE

RTECS NUMBER : XF8045000

CHEMICAL NAME : 2H-Tetrazolium,

3,3'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2-(

4-nitrophenyl)-5-phen yl-,dichloride




MOLECULAR FORMULA : C40-H30-N10-O6.2Cl




* NBT (dye)

* Nitro Blue tetrazolium

* p-Nitro Blue tetrazolium

* Nitro Blue tetrazolium chloride

* p-Nitro Blue tetrazolium chloride

* Nitro BT

* Nitrotetrazolium Blue

* p-Nitrotetrazolium Blue

* Nitro tetrazolium BT

* Nitrotetrazolium Chloride Blue

* Nitro Blue tetrazolium salt

* Tetrazolium Nitro Blue

* Tetrazolium nitro BT













NITROACETOPHENONE (2'-)

RTECS NUMBER : AM9600000

CHEMICAL NAME : Acetophenone, 2'-nitro-








WISWESSER LINE NOTATION : WNR BV1



* 2-Acetylnitrobenzene

* Ethanone, 1-(2-nitrophenyl)-

* Methyl 2-nitrophenyl ketone

* o-Nitroacetophenone

* 2'-Nitroacetophenone

* 1-(2-Nitrophenyl)ethanone







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **



DOSE/DURATION : 5 uL/disc

REFERENCE :



170,11,1986











WISWESSER LINE NOTATION : WNR CV1


Primary Irritant


* m-Acetylnitrobenzene


* Methyl 3-nitrophenyl ketone

* 3-Nitroacetofenon

* m-Nitroacetophenone


* 1-(3-Nitrophenyl)ethanone

* (3-Nitrophenyl) methyl ketone

* USAF MA-1








REFERENCE :



-,730,1986






TOXIC EFFECTS :


REFERENCE :

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.

(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.






TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : 3 mL/kg

TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **




REFERENCE :



9),1,1987











WISWESSER LINE NOTATION : WNR DV1



* p-Acetylnitrobenzene


* Methyl-p-nitrophenyl ketone

* p-Nitroacetophenone


* p-Nitrophenyl methyl ketone

* PNAP


** MUTATION DATA **




REFERENCE :



9),1,1987




REFERENCE :



188,267,1987




REFERENCE :



170,11,1986

NITROANILINE (2-)

RTECS NUMBER : BY6650000

CHEMICAL NAME : Aniline, o-nitro-






WISWESSER LINE NOTATION : ZR BNW



* 1-Amino-2-nitrobenzene

* Azoene Fast Orange GR Base

* Azogene Fast Orange GR

* Azoic Diazo Component 6

* Brentamine Fast Orange GR Base

* C.I. 37025

* C.I. Azoic Diazo Component 6

* Devol Orange B

* Diazo Fast Orange GR

* Fast Orange Base GR

* Fast Orange Base JR

* Fast Orange GR Base

* Fast Orange O Base

* Hiltonil Fast Orange GR Base

* o-Nitraniline

* 2-Nitroaniline

* Orange Base Ciba II

* Orange Base IRGA II

* Orange Salt Ciba II

* Orange Salt IRGA II







TOXIC EFFECTS :



REFERENCE :


(Kiev,







TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :



REFERENCE :


(Kiev,







TOXIC EFFECTS :


REFERENCE :



NJ






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :



NJ


** MUTATION DATA **




REFERENCE :





DOSE/DURATION : 15500 ng/well

REFERENCE :



133,161,1984




REFERENCE :



170,11,1986





REFERENCE :



320,273,1994




REFERENCE :



320,273,1994
























47,26992,82






CHEMICAL NAME : Aniline, m-nitro-






WISWESSER LINE NOTATION : ZR CNW



* Amarthol Fast Orange R Base

* m-Aminonitrobenzene


* Azobase MNA

* Benzenamine, 3-nitro-

* C.I. 37030


* Daito Orange Base R

* Devol Orange R

* Diazo Fast Orange R

* Fast Orange Base R

* Fast Orange M Base

* Fast Orange MM Base

* Fast Orange R Base

* Fast Orange R Salt

* Hiltonil Fast Orange R Base

* Naphtoelan Orange R Base

* Nitranilin

* m-Nitroaminobenzene

* 3-Nitroaniline

* 3-Nitrobenzenamine

* m-Nitrophenylamine

* Orange Base IRGA I







TOXIC EFFECTS :


REFERENCE :

AMRL** Aerospace Medical Research Laboratory Report. (Aerospace

Technical

Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH

45433)

Volume(issue)/page/year: TR-72-62,1972





TOXIC EFFECTS :


REFERENCE :


Technical


45433)






TOXIC EFFECTS :




REFERENCE :

JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35.

For

publisher information, see AEHLAU. Volume(issue)/page/year: 2,247,1920





TOXIC EFFECTS :



REFERENCE :


(Kiev,







TOXIC EFFECTS :


REFERENCE :



NJ







TOXIC EFFECTS :



Blood - normocytic anemia

REFERENCE :




(109),72,1991





TOXIC EFFECTS :



REFERENCE :


(Kiev,



** MUTATION DATA **




REFERENCE :

IJCMDW International Journal of Cosmetic Science. (Blackwell Scientific

Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1979-





REFERENCE :



170,11,1986









47,26992,82





CHEMICAL NAME : Aniline, p-nitro-






WISWESSER LINE NOTATION : ZR DNW


Mutagen



* p-Aminonitrobenzene


* Aniline, 4-nitro-

* Azoamine Red ZH

* Azoic Diazo Component 37

* Benzenamine, 4-nitro-

* C.I. 37035


* C.I. Developer 17

* Developer P

* Devol Red GG

* Diazo Fast Red GG

* Fast Red Base GG

* Fast Red Base 2J

* Fast Red 2G Base

* Fast Red GG Base

* Fast Red MP Base

* Fast Red P Base

* Naphtoelan Red GG Base

* NCI-C60786

* p-Nitraniline

* 4-Nitraniline

* Nitrazol CF Extra

* p-Nitroanilina

* p-Nitroaniline

* 4-Nitroaniline

* 4-Nitrobenzenamine

* p-Nitrophenylamine

* PNA

* RCRA waste number P077

* Red 2G Base

* Shinnippon Fast Red GG Base







TOXIC EFFECTS :


REFERENCE :

CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. (PNS-Ustredni

Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1-






TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :



42,417,1977





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

IGIBA5 Igiena. (Bucharest, Romania) V.5-23, 1956-74(?). For publisher

information, see RABIDH. Volume(issue)/page/year: 15,151,1966





TOXIC EFFECTS :



REFERENCE :


(Kiev,







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :



NJ






TOXIC EFFECTS :


REFERENCE :


DC)






TOXIC EFFECTS :


REFERENCE :



21,315,1972






TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :



NTP-TR-418,1993





TOXIC EFFECTS :




REFERENCE :



NTP-TR-418,1993






TOXIC EFFECTS :


Vascular - tumors

REFERENCE :



NTP-TR-418,1993





DOSE : 1764 mg/kg


female 14 week(s) pre-mating

TOXIC EFFECTS :



REFERENCE :







DOSE : 9600 mg/kg


TOXIC EFFECTS :


before birth)



gain)

REFERENCE :

TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,

Inc.,

41 E. 11th St., New York, NY 10003) V.1- 1980-


7,29,1987

** MUTATION DATA **




REFERENCE :



1),3,1983




REFERENCE :






REFERENCE :

MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see

EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-





REFERENCE :



170,11,1986




REFERENCE :



173,233,1986




REFERENCE :


E.


27,67,1996




REFERENCE :


E.


10(Suppl 10),1,1987

*** REVIEWS ***





TLV/BEI,1997

ACGIH TLV-TWA 3 mg/m3 (skin)




TLV/BEI,1997


MSHA STANDARD-air:TWA 1 ppm (6 mg/m3) (skin)




3,182,1971

OSHA PEL (Gen Indu):8H TWA 1 ppm (6 mg/m3) (skin)


Supt.


29,1910.1000,1994

OSHA PEL (Construc):8H TWA 1 ppm (6 mg/m3) (skin)


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 1 ppm (6 mg/m3) (skin)


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 1 ppm (6 mg/m3) (skin)


Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 1 ppm (6 mg/m3);Skin JAN 1993

OEL-AUSTRIA: MAK 1 ppm (6 mg/m3), Skin, JAN1999

OEL-AUSTRALIA:TWA 3 mg/m3;Skin JAN 1993

OEL-BELGIUM:TWA 3 mg/m3;Skin JAN 1993

OEL-DENMARK: TWA 0.5 ppm (3 mg/m3), Skin, JAN1999


OEL-JAPAN: OEL 3 mg/m3, Skin, JAN1999

OEL-GERMANY:TWA 1 ppm (6 mg/m3);Skin JAN 1993


OEL-THE NETHERLANDS:TWA 1 ppm (6 mg/m3);Skin JAN 1993


OEL-THE PHILIPPINES:TWA 1 ppm (6 mg/m3);Skin JAN 1993


OEL-SWITZERLAND:TWA 0.5 ppm (3 mg/m3);Skin JAN 1993

OEL-TURKEY:TWA 1 ppm (6 mg/m3);Skin JAN 1993

OEL-UNITED KINGDOM:TWA 1 ppm (6 mg/m3);STEL 2 ppm;Skin JAN 1993





NIOSH REL TO p-NITROANILINE-air:10H TWA 3 mg/m3 (Sk)

REFERENCE :



















EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse





47,26992,82



NIOSH Analytical Method, 1994: p-Nitroaniline, 5033

NPT Carcinogenesis Studies (gavage);equivocal evidence:mouse



NTP-TR-418,1993

NITROANISIDINE (PARA,2-)


CHEMICAL NAME : Aniline, 4-methoxy-2-nitro-








WISWESSER LINE NOTATION : WNR BZ EO1


* Acco Fast Bordeaux GP salt

* Amarthol Fast Bordeaux GP Base

* Amarthol Fast Bordeaux GP Salt

* p-Anisidine, 2-nitro-

* Atul Fast Bordeaux GP Base

* Azobase NAS

* Azoene Fast Bordeaux GP Base

* Azoene Fast Bordeaux GP Salt

* Azofix Bordeaux GP

* Azogene Fast Bordeaux G

* Benzenamine, 4-methoxy-2-nitro-

* Bordeaux Base Ciba IV

* Bordeaux Base Irga IV

* Bordeaux Base NGP

* Bordeaux GP Base

* Bordeaux GP Salt

* Bordeaux GPS Salt

* Bordeaux Salt Ciba IV

* Bordeaux Salt NGP

* Brentamine Fast Bordeaux GP Base

* Daito Bordeaux Base GP

* Daito Bordeaux Salt GP

* Devol Bordeaux B

* Diabase Bordeaux GP

* Diasalt Bordeaux GP

* Durgasol Bordeaux GP Salt

* Fast Bordeaux Base GP

* Fast Bordeaux Base J

* Fast Bordeaux GDN

* Fast Bordeaux GDN base

* Fast Bordeaux GP

* Fast Bordeaux GP Base

* Fast Bordeaux GP Salt

* Fast Bordeaux GP-T Base

* Fast Bordeaux 3NA Base

* Fast Bordeaux Salt GP

* Fast Bordeaux Salt GPN

* Fast Bordeaux Salt J

* GP-Amin

* Hansol Bordeaux Salt GP Salt

* Hiltonil Fast Bordeaux GP Base

* Hiltosal Fast Bordeaux GP Salt

* Hindasol Bordeaux GP Salt

* Kako Bordeaux GP Base

* Kako Bordeaux GP Salt

* Kayaku Fast Bordeaux GP Base

* Kayaku Fast Bordeaux Salt GP

* Lake Maroon B base

* 4-Methoxy-2-nitroanilin

* 4-Methoxy-2-nitroaniline

* Mitsui Bordeaux GP Base

* Mitsui Bordeaux GP Salt

* Naphthanil Bordeaux GP Base

* Naphthanil Diazo Bordeaux GP

* Naphthosol Fast Bordeaux GP Salt

* Naphtoelan Fast Bordeaux GP Base

* Natasol Bordeaux GP Salt

* Pharmasol Bordeaux GP

* Pharmazoid Bordeaux GP

* Sanyo Fast Bordeaux GP Base

* Sanyo Fast Bordeaux Salt GP

* Shinnippon Fast Bordeaux GP Base

* Sugai Fast Bordeaux GP Base

* Symulon Bordeaux GP Base

* Tulabase Fast Bordeaux GP







TOXIC EFFECTS :


REFERENCE :



-,718,1986



NITROANISOLE (4-)

RTECS NUMBER : BZ8800000

CHEMICAL NAME : Anisole, p-nitro-






WISWESSER LINE NOTATION : WNR DO1


Mutagen


* Benzene, 1-methoxy-4-nitro-

* p-Methoxynitrobenzene

* 1-Methoxy-4-nitrobenzene

* 4-Methoxynitrobenzene

* p-Nitroanisol

* p-Nitroanisole

* 4-Nitroanisole







TOXIC EFFECTS :


REFERENCE :

TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo

Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.






TOXIC EFFECTS :

Liver - fatty liver degeneration

Kidney, Ureter, Bladder - other changes

REFERENCE :

AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)

V.1-18, 1930-61. For publisher information, see IAEHDW.






TOXIC EFFECTS :

Behavioral - general anesthetic



REFERENCE :








TOXIC EFFECTS :


REFERENCE :

TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.

Toxicology of New Industrial Chemical Substances. For English translation,

see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-






TOXIC EFFECTS :


REFERENCE :



41,216,1977

** MUTATION DATA **




REFERENCE :






REFERENCE :

SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon

Sangyo

Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo

160,





REFERENCE :



170,11,1986






NITROANTHRACENE (9-)

RTECS NUMBER : CB0715000

CHEMICAL NAME : Anthracene, 9-nitro-






WISWESSER LINE NOTATION : L C666J BNW


Mutagen


* 5-Nitroanthracene

* 9-Nitroanthracene


** MUTATION DATA **




REFERENCE :



91,321,1981




REFERENCE :



371,123,1996

*** REVIEWS ***

IARC Cancer Review:Animal No Adequate Data


Chemicals


12210)




Chemicals


12210)






7,56,1987

NITROBENZALDEHYDE (2-)

RTECS NUMBER : CU7300000

CHEMICAL NAME : Benzaldehyde, o-nitro-






WISWESSER LINE NOTATION : WNR BVH



* Benzaldehyde, 2-nitro-

* o-Nitrobenzaldehyde

* 2-Nitrobenzaldehyde







TOXIC EFFECTS :




REFERENCE :

AFECAT Annales des Falsifications et de l'Expertise Chimique. (Paris,

France) V.53, No.613-No.779, 1960-79. Volume(issue)/page/year:

76(815),65,1983

** MUTATION DATA **



DOSE/DURATION : 1 umol/plate

REFERENCE :



58,11,1978




REFERENCE :



170,11,1986















CHEMICAL NAME : Benzaldehyde, m-nitro-






WISWESSER LINE NOTATION : WNR CVH




* 3-Formylnitrobenzene

* m-Nitrobenzaldehyde









TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :


Systems


21010)


** MUTATION DATA **




REFERENCE :



175,133,1986




REFERENCE :



170,11,1986














CHEMICAL NAME : Benzaldehyde, p-nitro-






WISWESSER LINE NOTATION : WNR DVH




* p-Formylnitrobenzene

* p-Nitrobenzaldehyde








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :

HINEL* Hine Laboratories Reports. (San Francisco, CA)

Volume(issue)/page/year: AF33(657)-11756,1964

** MUTATION DATA **




REFERENCE :



170,11,1986




REFERENCE :


Sangyo


160,





REFERENCE :



170,11,1986













NITROBENZALDEHYDE OXIME (4-)


CHEMICAL NAME : Benzaldehyde, p-nitro-, oxime






WISWESSER LINE NOTATION : WNR D1UNQ


* Benzaldehyde, 4-nitro-, oxime

* p-Nitrobenzaldehyde oxime

* 4-Nitrobenzaldehyde oxime

* p-Nitrobenzaldoxime

* 4-Nitrobenzaldoxime







TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :




NITROBENZAMIDE (3-)

RTECS NUMBER : CV5601250

CHEMICAL NAME : Benzamide, 3-nitro-










* Benzamide, m-nitro-

* m-Nitrobenzamide

* 3-Nitrobenzamide







TOXIC EFFECTS :


REFERENCE :


Translation





NITROBENZAMIDE (4-)

RTECS NUMBER : CV5601000

CHEMICAL NAME : Benzamide, p-nitro-






COMPOUND DESCRIPTOR : Primary Irritant


* Benzamide, 4-nitro-

* p-Nitrobenzamide

* 4-Nitrobenzamide






DOSE/DURATION : 2500 mg/10D (Intermittent)


REFERENCE :

EPASR* United States Environmental Protection Agency, Office of

Pesticides

and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,

SW,

Washington, DC 20460) History unknown. Volume(issue)/page/year:

8EHQ-0183-0462






TOXIC EFFECTS :




REFERENCE :

EPASR* United States Environmental Protection Agency, Office of

Pesticides

and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,

SW,

Washington, DC 20460) History unknown. Volume(issue)/page/year:

8EHQ-0183-0462





TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :


Translation






NITROBENZENE

RTECS NUMBER : DA6475000

CHEMICAL NAME : Benzene, nitro-






WISWESSER LINE NOTATION : WNR


Tumorigen

Mutagen


Human

Primary Irritant


* Essence of mirbane

* Essence of myrbane

* Mirbane oil

* NCI-C60082

* Nitrobenzeen

* Nitrobenzen

* Nitrobenzene

* Nitrobenzol

* Oil of mirbane

* Oil of myrbane









REFERENCE :



-,411,1986






REFERENCE :



-,411,1986






TOXIC EFFECTS :


Vascular - other changes


REFERENCE :

ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,

1954-74.

For publisher information, see ARTODN. Volume(issue)/page/year:

28,208,1971





TOXIC EFFECTS :


REFERENCE :


J.M.,






TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :



Volume(issue)/page/year: 0TS0570970





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :



Kidney, Ureter, Bladder - other changes

REFERENCE :








TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :


DC)






TOXIC EFFECTS :




REFERENCE :



1903/04-






TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :


DC)






TOXIC EFFECTS :


REFERENCE :


DC)






TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :

PCOC** Pesticide Chemicals Official Compendium, Association of the

American

Pesticide Control Officials, Inc., 1966. (Topeka, KS)






TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :



Behavioral - coma

REFERENCE :

RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La

Suisse

Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-






TOXIC EFFECTS :


REFERENCE :


(Leipzig,






TOXIC EFFECTS :


REFERENCE :








DOSE/DURATION : 2 gm/m3

TOXIC EFFECTS :


REFERENCE :










TOXIC EFFECTS :


REFERENCE :






DOSE/DURATION : 800 ug/m3/24H/73D-C

TOXIC EFFECTS :




levels - true cholinesterase

REFERENCE :







DOSE/DURATION : 50 ppm/6H/90D-I

TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Blood - changes in bone marrow (not otherwise specified)



REFERENCE :

DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,

New

York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 17,271,1994





TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :


Liver - tumors

REFERENCE :








TOXIC EFFECTS :




REFERENCE :








DOSE : 300 mg/kg


TOXIC EFFECTS :




REFERENCE :






DOSE : 1260 mg/kg


TOXIC EFFECTS :




Reproductive - Fertility - male fertility index (e.g. # males impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :

JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of

Toxicological

Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,





DOSE : 3180 mg/kg


female 2 week(s) pre-mating - 3 day(s) post-birth

TOXIC EFFECTS :


4

per # born alive)


gain)

REFERENCE :


Toxicological






DOSE : 5300 mg/kg


female 2 week(s) pre-mating - 3 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :


Toxicological






DOSE : 5 ppm/6H


TOXIC EFFECTS :




REFERENCE :






DOSE : 1260 ug/m3/4H


TOXIC EFFECTS :





abnormalities

REFERENCE :








DOSE : 40 ppm/6H


TOXIC EFFECTS :




Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,

accessory glands

REFERENCE :







DOSE : 41 ppm/6H


TOXIC EFFECTS :


REFERENCE :



** MUTATION DATA **




REFERENCE :

BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New

York,

NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986

*** REVIEWS ***





TLV/BEI,1997

ACGIH TLV-TWA 5 mg/m3 (1 ppm) (skin)




TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)




Chemicals


12210)



MSHA STANDARD-air:TWA 1 ppm (5 mg/m3) (skin)




3,183,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 1 ppm (5 mg/m3);Skin JAN 1993


OEL-AUSTRALIA:TWA 1 ppm (5 mg/m3);Skin JAN 1993

OEL-BELGIUM:TWA 1 ppm (5 mg/m3);Skin JAN 1993

OEL-DENMARK: TWA 1 ppm (5 mg/m3), Skin, JAN1999


OEL-JAPAN: OEL 1 ppm (5 mg/m3), Skin, JAN1999

OEL-GERMANY:TWA 1 ppm (5 mg/m3);Skin JAN 1993



OEL-JAPAN:TWA 1 ppm (5 mg/m3);Skin JAN 1993

OEL-SWEDEN: NGV 1 ppm (5 mg/m3), KTV 2 ppm (10 mg/m3), Skin, JAN1999

OEL-THE NETHERLANDS:TWA 1 ppm (5 mg/m3);Skin JAN 1993

OEL-RUSSIA:TWA 1 ppm;STEL 3 mg/m3;Skin JAN 1993

OEL-SWEDEN:TWA 1 ppm (5 mg/m3);STEL 2 ppm (10 mg/m3);Skin JAN 1993

OEL-SWITZERLAND:TWA 1 ppm (5 mg/m3);STEL 2 ppm (10 mg/m3);Skin JAN 1993

OEL-TURKEY:TWA 1 ppm (5 mg/m3);Skin JAN 1993

OEL-UNITED KINGDOM:TWA 1 ppm (5 mg/m3);STEL 2 ppm;Skin JAN 1993





NIOSH REL TO NITROBENZENE-air:10H TWA 1 ppm (Sk)

REFERENCE :























47,26992,82


EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8703;8EHQ-0293-8723

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8724;8EHQ-0892-9102

EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9103



NIOSH Analytical Method, 1994: Nitrobenzenes, 2005

NITROBENZENESULFONAMIDE (4-)

RTECS NUMBER : DB2975000

CHEMICAL NAME : Benzenesulfonamide, p-nitro-






MOLECULAR FORMULA : C6-H6-N2-O4-S


WISWESSER LINE NOTATION : ZSWR DNW



* p-Nitrobenzenesulfonamide







TOXIC EFFECTS :


REFERENCE :






NITROBENZIMIDAZOLE (5,6-)

RTECS NUMBER : DD9800000

CHEMICAL NAME : Benzimidazole, 6-nitro-






WISWESSER LINE NOTATION : T56 BM DNJ HNW


Tumorigen

Mutagen


* 1H-Benzimidazole, 5-nitro-

* Benzimidazole, 5(or 6)-nitro-

* NCI-C01912

* 5-Nitro-1H-benzimidazole

* 6-Nitro-benzimidazole







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


Liver - tumors

REFERENCE :








TOXIC EFFECTS :


Liver - tumors

REFERENCE :




** MUTATION DATA **




REFERENCE :



7),1,1986












NCI Carcinogenesis Bioassay (feed);clear evidence:mouse




NCI Carcinogenesis Bioassay (feed);no evidence:rat




NITROBENZOIC ACID (2-)

RTECS NUMBER : DH5050000

CHEMICAL NAME : Benzoic acid, o-nitro-






WISWESSER LINE NOTATION : WNR BVQ



* Benzoic acid, 2-nitro-

* o-Carboxynitrobenzene

* o-Nitrobenzoic acid

* 2-Nitrobenzoic acid


** MUTATION DATA **




REFERENCE :



58,11,1978




REFERENCE :


Sangyo


160,





REFERENCE :



170,11,1986




NOES Hazard Code - E0838











CHEMICAL NAME : Benzoic acid, m-nitro-








WISWESSER LINE NOTATION : WNR CVQ



* Benzoic acid, 3-nitro-

* m-Nitrobenzenecarboxylic acid

* m-Nitrobenzoic acid








TOXIC EFFECTS :



Behavioral - aggression

REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :



REFERENCE :







TOXIC EFFECTS :


REFERENCE :



** MUTATION DATA **




REFERENCE :



9),1,1987




REFERENCE :



170,11,1986















CHEMICAL NAME : Benzoic acid, p-nitro-






WISWESSER LINE NOTATION : WNR DVQ


Mutagen

Primary Irritant


* 1-Carboxy-4-nitrobenzene

* Kyselina p-nitrobenzoova

* p-Nitrobenzenecarboxylic acid

* p-Nitrobenzoic acid


* 4-Nitrodracylic acid








REFERENCE :



-,739,1986






TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :




REFERENCE :



NTP-TR-442,1994





TOXIC EFFECTS :




REFERENCE :



NTP-TR-442,1994





TOXIC EFFECTS :



REFERENCE :



NTP-TR-442,1994





TOXIC EFFECTS :


REFERENCE :



NTP-TR-442,1994






TOXIC EFFECTS :



REFERENCE :



NTP-TR-442,1994

** MUTATION DATA **




REFERENCE :



137,71,1984




REFERENCE :



9),1,1987




REFERENCE :



170,11,1986




REFERENCE :


States







REFERENCE :






REFERENCE :





















EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay



NTP Carcinogenesis Studies (feed);some evidence:rat



NTP-TR-442,1994

NTP Carcinogenesis Studies (feed);no evidence:mouse



NTP-TR-442,1994

NITROBENZONITRILE (3-)

RTECS NUMBER : DI4900000

CHEMICAL NAME : Benzonitrile, m-nitro-






WISWESSER LINE NOTATION : WNR CCN


Mutagen


* Benzonitrile, 3-nitro-

* m-Cyanonitrobenzene

* 3-Cyanonitrobenzene

* m-Nitrobenzonitrile

* 3-Nitrobenzonitrile







TOXIC EFFECTS :


REFERENCE :





** MUTATION DATA **




REFERENCE :






REFERENCE :



170,11,1986




NITROBENZONITRILE (4-)

RTECS NUMBER : DI4903500

CHEMICAL NAME : Benzonitrile, p-nitro-






WISWESSER LINE NOTATION : WNR DCN


Mutagen


* Benzonitrile, 4-nitro-

* p-Cyanonitrobenzene

* 4-Cyanonitrobenzene

* p-Nitrobenzonitrile

* 4-Nitrobenzonitrile







TOXIC EFFECTS :


REFERENCE :

ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt,

Fed.

Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969





TOXIC EFFECTS :


REFERENCE :

APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353

Vineuil,

France) V.1- 1943- Volume(issue)/page/year: 41,391,1983





TOXIC EFFECTS :


REFERENCE :

ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt,

Fed.

Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969

** MUTATION DATA **




REFERENCE :



170,11,1986




NITROBENZOYL CHLORIDE (2-)

RTECS NUMBER : DM6650000

CHEMICAL NAME : Benzoyl chloride, o-nitro-






MOLECULAR FORMULA : C7-H4-Cl-N-O3




* Benzoyl chloride, 2-nitro-

* o-Nitrobenzoyl chloride

* 2-Nitrobenzoyl chloride


** MUTATION DATA **




REFERENCE :



9),1,1987






CHEMICAL NAME : Benzoyl chloride, m-nitro-








WISWESSER LINE NOTATION : WNR CVG



* Benzoyl chloride, 3-nitro-

* Chlorid kyseliny m-nitrobenzoove

* m-Nitrobenzoyl chloride








TOXIC EFFECTS :


REFERENCE :



30,470,1969





TOXIC EFFECTS :


REFERENCE :



30,470,1969

** MUTATION DATA **




REFERENCE :



9),1,1987






CHEMICAL NAME : Benzoyl chloride, p-nitro-











* p-Nitrobenzoic acid chloride

* 4-Nitrobenzoic acid chloride

* p-Nitrobenzoyl chloride








TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :









TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :









TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :










TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :









DOSE : 11830 ug/m3/4H


TOXIC EFFECTS :




REFERENCE :





** MUTATION DATA **




REFERENCE :



9),1,1987




NITROBENZYL ALCOHOL (2-)

RTECS NUMBER : DP0657050

CHEMICAL NAME : Benzyl alcohol, o-nitro-










* Benzenemethanol, 2-nitro-

* o-Hydroxymethylnitrobenzene

* 2-Nitrobenzenemethanol

* o-Nitrobenzyl alcohol

* 2-Nitrobenzyl alcohol


** MUTATION DATA **




REFERENCE :


Ireland


52,203,1990

NITROBENZYL ALCOHOL (4-)


CHEMICAL NAME : Benzyl alcohol, p-nitro-










* Benzenemethanol, 4-nitro-

* p-(Hydroxymethyl)nitrobenzene

* 4-Nitrobenzenemethanol

* p-Nitrobenzyl alcohol

* 4-Nitrobenzyl alcohol

* (4-Nitrophenyl)methanol


** MUTATION DATA **




REFERENCE :


Ireland


52,203,1990



NITROBENZYL BROMIDE (4-)

RTECS NUMBER : XS7967000

CHEMICAL NAME : Toluene, alpha-bromo-p-nitro-




MOLECULAR FORMULA : C7-H6-Br-N-O2


WISWESSER LINE NOTATION : WNR D1E



* Benzene, 1-(bromomethyl)-4-nitro-

* p-(Bromomethyl)nitrobenzene

* 4-(Bromomethyl)nitrobenzene

* alpha-Bromo-p-nitrotoluene

* p-Nitrobenzyl bromide

* 4-Nitrobenzyl bromide







TOXIC EFFECTS :


REFERENCE :


Systems


21010)


** MUTATION DATA **




REFERENCE :






REFERENCE :



348,137,1995




REFERENCE :






NITROBENZYL CHLORIDE (2-)


CHEMICAL NAME : Toluene, alpha-chloro-o-nitro-








WISWESSER LINE NOTATION : WNR B1G



* Benzene, 1-(chloromethyl)-2-nitro-

* 1-(Chloromethyl)-2-nitrobenzene

* alpha-Chloro-o-nitrotoluene

* o-Nitrobenzyl chloride

* 2-Nitrobenzyl chloride


** MUTATION DATA **




REFERENCE :


Sangyo


160,





REFERENCE :



9),1,1987




REFERENCE :



170,11,1986





CHEMICAL NAME : Toluene, alpha-chloro-m-nitro-










* alpha-Chloro-m-nitrotoluene

* m-Nitrobenzyl chloride

* 3-Nitrobenzyl chloride


** MUTATION DATA **




REFERENCE :



170,11,1986




REFERENCE :



9),1,1987




REFERENCE :



170,11,1986





CHEMICAL NAME : Toluene, alpha-chloro-p-nitro-






WISWESSER LINE NOTATION : WNR D1G




* p-(Chloromethyl)nitrobenzene


* 4-(Chloromethyl)nitrobenzene

* alpha-Chloro-p-nitrotoluene

* p-Nitrobenzyl chloride







TOXIC EFFECTS :


REFERENCE :



1989-





DOSE/DURATION : 280 mg/m3/4H

TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :



1989-


** MUTATION DATA **




REFERENCE :



170,11,1986




REFERENCE :

NTPTB* NTP Technical Bulletin. (National Toxicology Program, Landow

Bldg.

3A-06, 7910 Woodmont Ave., Bethesda, MD 20205) Volume(issue)/page/year:

APR1982




REFERENCE :



170,11,1986




REFERENCE :


Baffins






NITROBENZYL PYRIDINE (4,4-)

RTECS NUMBER : UT6360000

CHEMICAL NAME : Pyridine, 4-(p-nitrobenzyl)-








WISWESSER LINE NOTATION : T6NJ D1R DNW


* 1-(p-Nitrobenzyl)pyridine







TOXIC EFFECTS :


REFERENCE :


Systems


21010)





NOES Hazard Code - E0062








NITROBENZYLAMINE HYDROCHLORIDE (4-)


CHEMICAL NAME : Benzylamine, p-nitro-, hydrochloride




MOLECULAR FORMULA : C7-H8-N2-O2.Cl-H


WISWESSER LINE NOTATION : Z1R DNW &GH


* p-Nitrobenzylamine hydrochloride







TOXIC EFFECTS :


REFERENCE :


Systems


21010)


NITROCINNAMALDEHYDE (TRANS-)

RTECS NUMBER : GD6650000

CHEMICAL NAME : Cinnamaldehyde, p-nitro-








WISWESSER LINE NOTATION : WNR D1U1VH


* p-Nitrocinnamaldehyde

* 4-Nitrocinnamaldehyde

* 3-(4-Nitrophenyl)-2-propenal

* 2-Propenal, 3-(4-nitrophenyl)-







TOXIC EFFECTS :



REFERENCE :







NITROCINNAMIC ACID (2-)

RTECS NUMBER : UD3642850

CHEMICAL NAME : 2-Propenoic acid, 3-(2-nitrophenyl)-








* Cinnamic acid, o-nitro-

* 3-(2-Nitrophenyl)-2-propenoic acid

* o-Nitrocinnamic acid

* 2-Nitrocinnamic acid

* 3-(2-Nitrophenyl)propenoic acid







TOXIC EFFECTS :


Behavioral - ataxia

Behavioral - rigidity (including catalepsy)

REFERENCE :

IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz

(East), Bombay 400 029, India) V.40(2)- 1978-


49,77,1987


RTECS NUMBER : GE0352000

CHEMICAL NAME : Cinnamic acid, m-nitro-







Mutagen


* 3-Nitrobenzenepropenoic acid

* m-Nitrocinnamic acid


* 2-Propenoic acid, 3-(3-nitrophenyl)-







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :




49,77,1987

** MUTATION DATA **




REFERENCE :



170,11,1986




REFERENCE :



170,11,1986




RTECS NUMBER : GE0353000

CHEMICAL NAME : Cinnamic acid, p-nitro-







Mutagen


* p-Nitrocinnamic acid


* 3-(4-Nitrophenyl)acrylic acid

* 3-(4-Nitrophenyl)propenoic acid

* 2-Propenoic acid, 3-(4-nitrophenyl)-







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :




49,77,1987

** MUTATION DATA **




REFERENCE :



170,11,1986




REFERENCE :



188,267,1987




REFERENCE :



170,11,1986



NITROETHANE

RTECS NUMBER : KI5600000

CHEMICAL NAME : Ethane, nitro-






WISWESSER LINE NOTATION : WN2


Human


* Nitroetan

* Nitroethane







TOXIC EFFECTS :

Lungs, Thorax, or Respiration - respiratory obstruction



REFERENCE :

JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270

Madison Ave., New York, NY 10016) V.19- 1982-


32,321,1994





TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

85INA8 "Documentation of the Threshold Limit Values and Biological

Exposure

Indices," 5th ed., Cincinnati, OH, American Conference of Governmental

Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1105,1991





TOXIC EFFECTS :


REFERENCE :

BSPLA9 Bulletin de la Societe de Pharmacie de Lille. (Societe de

Pharmacie

du Lille, 3, rue du Professeur Laguesse, 59045 Lille, Franch) V.1- 1945-






TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :

KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical

Journal.

For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095

Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 10(6),53,1976





TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :







DOSE/DURATION : 1000 ppm/6H/13W-I

TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


specified



REFERENCE :




*** REVIEWS ***





TLV/BEI,1997






3,185,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994


OEL-AUSTRALIA:TWA 100 ppm (310 mg/m3) JAN 1993


OEL-BELGIUM:TWA 100 ppm (307 mg/m3) JAN 1993








OEL-SWEDEN: TWA 20 ppm (60 mg/m3), STEL 50 ppm (150 mg/m3), JAN1999



OEL-UNITED KINGDOM:TWA 100 ppm (310 mg/m3) JAN 1993





NIOSH REL TO NITROETHANE-air:10H TWA 100 ppm

REFERENCE :

















NIOSH Analytical Method, 1994: Nitroethane, 2526

NITROETHANOL (2-)

RTECS NUMBER : KL9370000

CHEMICAL NAME : Ethanol, 2-nitro-








WISWESSER LINE NOTATION : WN2Q



* beta-Nitroalcohol

* 2-Nitroethanol







TOXIC EFFECTS :


REFERENCE :


Journal.



** MUTATION DATA **




REFERENCE :


E.


19(Suppl 21),2,1992

NITROFURALDEHYDE (5:2-)

RTECS NUMBER : LT7200000

CHEMICAL NAME : 2-Furaldehyde, 5-nitro-








WISWESSER LINE NOTATION : T5OJ BVH ENW



* 5-Furancarboxaldehyde, 5-nitro-

* 5-Nitro-2-furaldehyde

* 5-Nitro-5-furancarboxaldehyde

* Nitrofurfural

* 5-Nitrofurfural

* 5-Nitrofurfuraldehyde


** MUTATION DATA **




REFERENCE :



192,15,1987




REFERENCE :



81,21,1981




REFERENCE :



81,21,1981




REFERENCE :







REFERENCE :

AFRNDS Acta Facultatis Rerum Naturalium Universitatis Comenianae,

Formatio

et Protectio Naturae. (Slovenske Pedagogicke Nakladatel'stvo, Sasinkova

5,

89112 Bratislava, Czechoslovakia) No.1- 1976-


5,131,1979


EPA GENETOX PROGRAM 1988, Negative: TRP reversion; S cerevisiae gene

conversion

NITROFURANTOIN

RTECS NUMBER : MU2800000

CHEMICAL NAME : Hydantoin, 1-((5-nitrofurfurylidene)amino)-






WISWESSER LINE NOTATION : T5OJ BNW E1UN- AT5NVMV EHJ


Drug

Mutagen


Human


* Berkfurin

* Chemiofuran

* Cyantin

* Dantafur

* Furadantin

* Furadantoin

* Furadonin

* Furadonine

* Furantoin

* Furatoin

* Furobactina

* 2,4-Imidazolidinedione, 1-(((5-nitro-2-furanyl)methylene)amino)-

* Ituran

* Macrodantin

* NCI-C55196

* Nifurantin

* Nitrofurantoin

* N-(5-Nitrofurfurylidene)-1-aminohydantoin

* N-(5-Nitro-2-furfurylidene)-1-aminohydantoin

* 1-((5-Nitrofurfurylidene)amino)hydantoin

* N-(5-Nitro-2-furfurylideno)-1-aminohydantoina

* NSC 2107

* Orafuran

* Urizept

* USAF EA-2

* Welfurin

* Zoofurin







TOXIC EFFECTS :

Lungs, Thorax, or Respiration - fibrosis (interstitial)



REFERENCE :

PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd.,

POB

88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 73,519,1997





TOXIC EFFECTS :

Kidney, Ureter, Bladder - interstitial nephritis



REFERENCE :







TOXIC EFFECTS :

Peripheral Nerve and Sensation - recording from peripheral motor nerve

Behavioral - ataxia

REFERENCE :

ARNEAS Archives of Neurology (Chicago). (AMA, 535 N. Dearborn St.,

Chicago,






TOXIC EFFECTS :

Brain and Coverings - increased intracranial pressure

Sense Organs and Special Senses (Eye) - visual field changes


REFERENCE :

DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati,

OH






TOXIC EFFECTS :

Blood - other hemolysis with or without anemia

REFERENCE :

AJCPAI American Journal of Clinical Pathology. (Lippincott/Harper,

Journal


1931-






TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse

Liver - jaundice, other or unclassified


REFERENCE :

MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co.

Ltd.,

71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-






TOXIC EFFECTS :


REFERENCE :




2,1044,1976





TOXIC EFFECTS :


REFERENCE :

RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry.

(New

York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:

2,303,1970





TOXIC EFFECTS :


REFERENCE :

RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry.

(New

York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:

2,303,1970





TOXIC EFFECTS :


REFERENCE :



DC






TOXIC EFFECTS :


REFERENCE :






SPECIES OBSERVED : Bird - chicken


TOXIC EFFECTS :


REFERENCE :

JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,

Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 112,1741,1982





TOXIC EFFECTS :


REFERENCE :

BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale

Farmaceutica,

Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-


102,505,1963






TOXIC EFFECTS :



REFERENCE :



NTP-TR-341,1989





TOXIC EFFECTS :



REFERENCE :



NTP-TR-341,1989





TOXIC EFFECTS :



REFERENCE :



NTP-TR-341,1989





TOXIC EFFECTS :



REFERENCE :



NTP-TR-341,1989






TOXIC EFFECTS :



REFERENCE :



NTP-TR-341,1989





TOXIC EFFECTS :


Reproductive - Tumorigenic effects - ovarian tumors

REFERENCE :



NTP-TR-341,1989





TOXIC EFFECTS :



REFERENCE :


Ireland


21,303,1984





DOSE : 140 mg/kg


TOXIC EFFECTS :



REFERENCE :

JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,

Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 77,275,1957




DOSE : 2100 mg/kg


TOXIC EFFECTS :



REFERENCE :


Preston


53,585,1953




DOSE : 1740 mg/kg


female 2 week(s) pre-mating - 2 week(s) after

conception

TOXIC EFFECTS :



REFERENCE :







DOSE : 1920 mg/kg


female 2 week(s) pre-mating - 3 week(s) after

conception

TOXIC EFFECTS :


4

per # born alive)


gain)

REFERENCE :







DOSE : 105 gm/kg


TOXIC EFFECTS :


REFERENCE :

TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,

Warner-Lambert

Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)

V.6(3/4)-





DOSE : 87500 ug/kg


TOXIC EFFECTS :



REFERENCE :

PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam,

Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year:

17,405,1976




DOSE : 75 mg/kg


TOXIC EFFECTS :


appendages

REFERENCE :








DOSE : 750 mg/kg


TOXIC EFFECTS :


abnormalities

REFERENCE :


(Alan



** MUTATION DATA **




REFERENCE :



NTP-TR-341,1989




REFERENCE :



1),3,1983



DOSE/DURATION : 500 nmol/well

REFERENCE :



34,2266,1974




REFERENCE :



175,149,1986




REFERENCE :


Ireland


58,69,1986




REFERENCE :

BJCSB5 British Journal of Cancer, Supplement. (Macmillan Press Ltd.,

Houndmills, Basingstoke, Hants. RG21 2ZS, UK) No.1- 1973-





REFERENCE :






REFERENCE :



244,55,1990




REFERENCE :






REFERENCE :



67,145,1979




REFERENCE :



244,55,1990




REFERENCE :

CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:

Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher

information, see CRASEV. Volume(issue)/page/year: 272,886,1971




DOSE/DURATION : 5 mmol/L/48H

REFERENCE :



222,359,1989


TEST SYSTEM : Mold - Aspergillus nidulans


REFERENCE :



26,159,1974




REFERENCE :

JPROAR Journal of Protozoology. (Soc. of Protozoologists, P.O. Box 368,

Lawrence, KS 66044) V.1- 1954- Volume(issue)/page/year: 17,129,1970



TEST SYSTEM : Fish - not otherwise specified


REFERENCE :


Ireland


80,317,1991




REFERENCE :


Ireland


45,77,1983


TEST SYSTEM : Human Bacteria - Salmonella typhimurium


REFERENCE :


V.1-60,



58,871,1977





REFERENCE :


Ireland


45,77,1983




REFERENCE :


Ireland


45,77,1983


TEST SYSTEM : Rodent - rat Yeast - Saccharomyces cerevisiae


REFERENCE :



67,145,1979



DOSE/DURATION : 1 gm/kg/4D (Continuous)

REFERENCE :


Ireland


15,69,1976


TEST SYSTEM : Rodent - rat Yeast - Saccharomyces cerevisiae


REFERENCE :



67,145,1979

TYPE OF TEST : Sperm Morphology




REFERENCE :

JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,

Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year:

112,348,1974





REFERENCE :


Ireland


45,77,1983




REFERENCE :


Ireland


16,223,1977




REFERENCE :

ONCODU Revista de Chirurgui, Oncologie, Radiologie, ORL, Oftalmologie,

Stomatologie, Seria: Oncologia. (Rompresfilatelia, POB 12-201,

Bucharest,

Romania) V.13(4)- 1974- Volume(issue)/page/year: 19,183,1980





REFERENCE :


Ireland


45,77,1983




REFERENCE :



NTP-TR-341,1989




REFERENCE :



225,181,1989




REFERENCE :



NTP-TR-341,1989




REFERENCE :

AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52



3,253,1980




REFERENCE :




(96),55,1978




REFERENCE :



NTP-TR-341,1989




REFERENCE :



225,181,1989

*** REVIEWS ***



Chemicals


12210)




Chemicals


12210)




Chemicals


12210)


TOXICOLOGY REVIEW

CCSUDL Carcinogenesis--A Comprehensive Survey. (Raven Press, 1185 Ave. of

the Americas, New York, NY 10036) V.1- 1976-


4,171,1978

TOXICOLOGY REVIEW


Corporate


2,365,1973

TOXICOLOGY REVIEW

TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX)

V.1-41(2),

1943-81/82. Discontinued. Volume(issue)/page/year: 25,270,1967











EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Host-mediated assay

EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Histidine

reversion-Ames test

EPA GENETOX PROGRAM 1988, Positive: TRP reversion; S cerevisiae gene

conversion

EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion

EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm

morphology-mouse

EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast

EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; Sperm

morphology-human


NTP Carcinogenesis Studies (feed);clear evidence:mouse



NTP-TR-341,1989

NTP Carcinogenesis Studies (feed);some evidence:rat



NTP-TR-341,1989

NITROGEN

RTECS NUMBER : QW9700000

CHEMICAL NAME : Nitrogen




MOLECULAR FORMULA : N2


WISWESSER LINE NOTATION : .N2


* Nitrogen

* Nitrogen gas

*** REVIEWS ***

ACGIH TLV-Simple asphyxiant, NO TWA




TLV/BEI,1997


MSHA STANDARD:ASPHYXIANTS/GASES




OSHA PEL (Construc): simple asphyxiant-inert gases and vapors


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):Simple asphyxiant - inert gas and vapor


Supt.


29,1915.1000,1993


OEL-THE NETHERLANDS:Asphyxiant JAN 1993

OEL-UNITED KINGDOM:Asphyxiant JAN 1993





























NITROINDAZOLE (5-)

RTECS NUMBER : NK7962000

CHEMICAL NAME : 1H-Indazole, 5-nitro-








WISWESSER LINE NOTATION : T56 BMNJ GNW



* 5-Nitroindazole

* 5-Nitro-1H-indazole


** MUTATION DATA **




REFERENCE :



58,11,1978













NITROINDOLE (7-)

RTECS NUMBER : NM1169000

CHEMICAL NAME : Indole, 7-nitro-








WISWESSER LINE NOTATION : T56 BMJ INW



* 7-Nitroindole

* 7-Nitro-1H-indole


** MUTATION DATA **




REFERENCE :



58,11,1978



NITROISATIN (5-)

RTECS NUMBER : NL7970000

CHEMICAL NAME : Indole-2,3-dione, 5-nitro-








WISWESSER LINE NOTATION : T56 BMVVJ GNW



* 1H-Indole-2,3-dione, 5-nitro-

* Isatin, 5-nitro-

* 5-Nitroindole-2,3-dione

* 5-Nitro-1H-indole-2,3-dione

* 5-Nitroisatin


** MUTATION DATA **




REFERENCE :



58,11,1978



NITROMETHANE

RTECS NUMBER : PA9800000

CHEMICAL NAME : Methane, nitro-




MOLECULAR FORMULA : C-H3-N-O2





* Nitrocarbol

* Nitrometan

* Nitromethane







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Pharmacie







TOXIC EFFECTS :


REFERENCE :







DOSE/DURATION : 18 gm/m3/2H

TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :


Journal.







TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in both tubules and glomeruli


REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,

1955-60.

For publisher information, see AEHLAU. Volume(issue)/page/year:

11,102,1955





TOXIC EFFECTS :



REFERENCE :


1955-60.


11,102,1955





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


1955-60.


11,102,1955





TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :





REFERENCE :







DOSE/DURATION : 10500 uL/kg/15W-C

TOXIC EFFECTS :




REFERENCE :


1955-60.


11,102,1955





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Peripheral Nerve and Sensation - structural change in nerve or sheath

Sense Organs and Special Senses (Olfaction) - deviated nasal septum

REFERENCE :



NTP-TR-461,1997





TOXIC EFFECTS :



REFERENCE :



NTP-TR-461,1997





TOXIC EFFECTS :




REFERENCE :



NTP-TR-461,1997





TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - deviated nasal septum



REFERENCE :



NTP-TR-461,1997





TOXIC EFFECTS :





REFERENCE :









TOXIC EFFECTS :



REFERENCE :



NTP-TR-461,1997





TOXIC EFFECTS :


Sense Organs and Special Senses (Eye) - tumors

Liver - tumors

REFERENCE :



NTP-TR-461,1997

*** REVIEWS ***





TLV/BEI,1997






3,187,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994










OEL-UNITED KINGDOM:TWA 100 ppm (250 mg/m3);STEL 150 ppm JAN 1993


OEL-SWEDEN: NGV 20 ppm (50 mg/m3), KTV 50 ppm (125 mg/m3), JAN1999






















NIOSH Analytical Method, 1994: Nitromethane, 2527

NTP Carcinogenesis Studies (inhalation);clear evidence:mouse,rat



NTP-TR-461,1997


NITRONAPHTHALENE (1-)


CHEMICAL NAME : Naphthalene, 1-nitro-








WISWESSER LINE NOTATION : L66J BNW


Mutagen


* NCI-C01956

* Nitrol

* 1-Nitronaftalen

* alpha-Nitronaphthalene

* 1-Nitronaphthalene







TOXIC EFFECTS :


Liver - hepatitis (hepatocellular necrosis), diffuse

REFERENCE :


Baffins



** MUTATION DATA **




REFERENCE :



5),1,1985




REFERENCE :



192,239,1987





REFERENCE :



341,161,1995




REFERENCE :







REFERENCE :


E.


15(Suppl 17),10,1990




REFERENCE :



259,111,1991

*** REVIEWS ***

IARC Cancer Review:Animal Inadequate Evidence


Chemicals


12210)




Chemicals


12210)




Chemicals


12210)




OEL-AUSTRIA: Suspected Carcinogen, JAN1999


EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat







NITRONAPHTHALENE (2-)


CHEMICAL NAME : Naphthalene, 2-nitro-








WISWESSER LINE NOTATION : L66J CNW


Mutagen


* beta-Nitronaphthalene

* 2-Nitronaphthalene







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :





REFERENCE :







DOSE/DURATION : 2400 mg/kg/34/W-I

TOXIC EFFECTS :



REFERENCE :

XPHCI* U.S. Public Health Service, Current Intelligence Bulletin.

(National

Institute for Occupational Safety and Health, 5600 Fishers Lane,

Rockville,

MD 20857) Volume(issue)/page/year: 17DEC1976





TOXIC EFFECTS :



REFERENCE :

GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)

V.1-75,

1907-84. For publisher information, see JJCREP.


61,79,1970

** MUTATION DATA **




REFERENCE :



216,211,1989




REFERENCE :


States







REFERENCE :



192,239,1987




REFERENCE :






DOSE/DURATION : 1 pph

REFERENCE :







REFERENCE :



393,23,1997




REFERENCE :



393,23,1997


TEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium


REFERENCE :







REFERENCE :

IJCNAW International Journal of Cancer. (International Union Against

Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1-

1966-


*** REVIEWS ***



Chemicals


12210)




Chemicals


12210)




Chemicals


12210)





OEL-SWITZERLAND:TWA 0.035 ppm (0.25 mg/m3);Carcinogen JAN 1993



NIOSH REL TO 2-NITRONAPHTHALENE-air:CA lowest feasible conc.

REFERENCE :





EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Host-mediated assay

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine

reversion-Ames test

EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis


NIOSH CURRENT INTELLIGENCE BULLETIN 16, 1976

NITRONIUM TETRAFLUOROBORATE

RTECS NUMBER : QX8620000

CHEMICAL NAME : Nitronium, tetrafluoroborate(1-)




MOLECULAR FORMULA : B-F4.N-O2


WISWESSER LINE NOTATION : .N-OI.B-F4


* Borate(1-), tetrafluoro-, nitryl

* Nitryl fluoborate

* Nitryl tetrafluoroborate







TOXIC EFFECTS :


REFERENCE :


Systems


21010)





Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994



NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3

REFERENCE :






NITROPHENOL (2-)

RTECS NUMBER : SM2100000

CHEMICAL NAME : Phenol, o-nitro-






WISWESSER LINE NOTATION : WNR BQ


* 2-Hydroxynitrobenzene

* o-Nitrofenol

* 2-Nitrophenol

* Phenol, 2-nitro-







TOXIC EFFECTS :


REFERENCE :


Labor




8,145,1972





TOXIC EFFECTS :


Behavioral - coma

REFERENCE :


Suisse







TOXIC EFFECTS :


REFERENCE :


Technical


45433)






TOXIC EFFECTS :


REFERENCE :



DC






TOXIC EFFECTS :


REFERENCE :

HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders

Co.,

1956-59 Volume(issue)/page/year: 5,120,1959





TOXIC EFFECTS :


REFERENCE :



-,675,1986





TOXIC EFFECTS :


REFERENCE :


Co.,






TOXIC EFFECTS :



REFERENCE :


Toxicology,


V.1-






TOXIC EFFECTS :


REFERENCE :


Co.,






TOXIC EFFECTS :


Behavioral - coma

REFERENCE :


Suisse







TOXIC EFFECTS :


REFERENCE :


Co.,


*** REVIEWS ***

TOXICOLOGY REVIEW



47,75,1978






















CHEMICAL NAME : Phenol, m-nitro-






WISWESSER LINE NOTATION : WNR CQ


Primary Irritant


* m-Hydroxynitrobenzene


* m-Nitrofenol

* 3-Nitrophenol








REFERENCE :



-,675,1986






REFERENCE :



-,675,1986






TOXIC EFFECTS :


REFERENCE :


Labor




8,145,1972





TOXIC EFFECTS :


Behavioral - coma

REFERENCE :


Suisse







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :

RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale.

(Brussels,

Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6.






TOXIC EFFECTS :


REFERENCE :



-,675,1986





TOXIC EFFECTS :


Behavioral - coma

REFERENCE :


Suisse







TOXIC EFFECTS :

Behavioral - tremor


Behavioral - ataxia

REFERENCE :


Suisse







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **




REFERENCE :


Sangyo


160,





REFERENCE :



170,11,1986

*** REVIEWS ***

TOXICOLOGY REVIEW



47,75,1978







CHEMICAL NAME : Phenol, p-nitro-






WISWESSER LINE NOTATION : WNR DQ


Tumorigen

Mutagen



* NCI-C55992

* Niphen

* p-Nitrofenol

* 4-Nitrofenol

* 4-Nitrophenol

* Paranitrofenol

* Paranitrofenolo

* Paranitrophenol








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


Behavioral - coma

REFERENCE :


Suisse







TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1

E.


8,302,1978





TOXIC EFFECTS :


REFERENCE :


DC)






TOXIC EFFECTS :


REFERENCE :

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,

Springer-Verlag

New York, Inc., 1971 Volume(issue)/page/year: -,97,1971





TOXIC EFFECTS :


Behavioral - ataxia

REFERENCE :








TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


Behavioral - coma

REFERENCE :


Suisse







TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :

Behavioral - tremor


Behavioral - ataxia

REFERENCE :


Suisse







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **




REFERENCE :



89,95,1981




REFERENCE :



170,11,1986




REFERENCE :

BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946,

Leipzig

DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year:

95,463,1976




REFERENCE :

IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26,

1971-78. For publisher information, see IAPUDO.


10,161,1974




REFERENCE :


E.


24,181,1994

*** REVIEWS ***

TOXICOLOGY REVIEW



47,75,1978





54,7740,1989

















EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay





NTP Carcinogenesis Studies (dermal); no evidence: mouse



NTP-TR-417,1993

NITROPHENYL ACETATE (4-)


CHEMICAL NAME : Acetic acid, p-nitrophenyl ester








WISWESSER LINE NOTATION : WNR DOV1


* Acetic acid, 4-nitrophenyl ester

* p-Acetoxynitrobenzene

* p-Nitrophenol acetate

* p-Nitrophenyl acetate

* 4-Nitrophenyl acetate







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :


REFERENCE :


Systems


21010)




NITROPHENYL DISULFIDE (4-)

RTECS NUMBER : JO1550000

CHEMICAL NAME : Disulfide, bis(p-nitrophenyl)




MOLECULAR FORMULA : C12-H8-N2-O4-S2


WISWESSER LINE NOTATION : WNR DSSR DNW



* Bis(p-nitrophenyl)disulfide

* Bis(4-nitrophenyl)disulfide

* p,p'-Dinitrodiphenyl disulfide

* 4,4'-Dinitrodiphenyl disulfide

* Di-4-nitrophenyl disulfide

* Disulfide, bis(4-nitrophenyl)

* p-Nitrophenyl disulfide

* 4-Nitrophenyl disulfide







TOXIC EFFECTS :


REFERENCE :


Baffins



** MUTATION DATA **




REFERENCE :



67,123,1979




NITROPHENYL HYDRAZINE (2-)

RTECS NUMBER : MV8210000

CHEMICAL NAME : Hydrazine, (o-nitrophenyl)-








WISWESSER LINE NOTATION : ZMR BNW



* 2-Nitrophenylhydrazine







TOXIC EFFECTS :


REFERENCE :


Systems


21010)


** MUTATION DATA **




REFERENCE :

AEMIDF Applied and Environmental Microbiology. (American Soc. for






REFERENCE :



173,233,1986

NITROPHENYLACETIC ACID (4-)


CHEMICAL NAME : Acetic acid, (p-nitrophenyl)-






WISWESSER LINE NOTATION : WNR D1VQ


Mutagen


* Benzeneacetic acid, 4-nitro-

* 4-Nitrobenzeneacetic acid

* 2-(4-Nitrophenoxy)acetic acid

* (p-Nitrophenyl)acetic acid

* 2-(p-Nitrophenyl)acetic acid

* (4-Nitrophenyl)acetic acid







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **




REFERENCE :



170,11,1986



NITROPHENYLACETIC ACID (META-)


CHEMICAL NAME : Acetic acid, (m-nitrophenyl)-










* Benzeneacetic acid, 3-nitro-

* 3-Nitrobenzeneacetic acid

* (m-Nitrophenyl)acetic acid

* 3-Nitrophenylacetic acid


** MUTATION DATA **




REFERENCE :



170,11,1986

NITROPHENYLACETONITRILE (4-)


CHEMICAL NAME : Acetonitrile, (p-nitrophenyl)-








WISWESSER LINE NOTATION : WNR D1CN


* Benzeneacetonitrile, 4-nitro-

* p-Nitrobenzeneacetonitrile

* 4-Nitrobenzeneacetonitrile

* 4-Nitro-benzyl-cyanid

* p-Nitrobenzylcyanide

* 4-Nitrobenzyl cyanide

* p-Nitrophenylacetonitrile

* 4-Nitrophenylacetonitrile







TOXIC EFFECTS :


REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,



14,1325,1965





TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory

change


REFERENCE :

PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1

E.


2,95,1972





TOXIC EFFECTS :


REFERENCE :


Systems


21010)




NITROPHENYLALANINE MONOHYDRATE (PARA-)

RTECS NUMBER : AY7400000

CHEMICAL NAME : Alanine, 3-(p-nitrophenyl)-, L-








WISWESSER LINE NOTATION : WNR D1YZVQ


* p-Nitrophenylalanine

* L-beta-Nitrophenylalanine

* L-3-(p-Nitrophenyl)alanine

* L-p-Nitrophenylalanine

* L-4-Nitrophenylalanine

* 4-Nitro-L-phenylalanine

* L-Phenylalanine, 4-nitro-







TOXIC EFFECTS :


REFERENCE :


Systems


21010)


NITROPHENYLAZO RESORCINOL (4,4-)

RTECS NUMBER : VH2810000

CHEMICAL NAME : Resorcinol, 4-((p-nitrophenyl)azo)-







* 1,3-Benzenediol, 4-((4-nitrophenyl)azo)-

* p-Diazviolet

* Magneson

* Magneson I

* p-Nitrobenzeneazoresorcinol

* 4-(p-Nitrophenylazo)resorcinol

* 4-(4-Nitrophenyl)azoresorcinol







TOXIC EFFECTS :


REFERENCE :






NITROPHENYLAZONAPHTHOL (4,4,1-)


CHEMICAL NAME : 1-Naphthol, 4-((p-nitrophenyl)azo)-









* Magneson II

* 1-Naphthalenol, 4-((4-nitrophenyl)azo)-

* 4-((p-Nitrophenyl)azo)-1-naphthol







TOXIC EFFECTS :


REFERENCE :






NITROPHENYLENEDIAMINE (4,1,2-)

RTECS NUMBER : ST2975000

CHEMICAL NAME : o-Phenylenediamine, 4-nitro-








WISWESSER LINE NOTATION : ZR BZ DNW


Mutagen



* 2-Amino-4-nitroaniline

* C.I. 76020

* 1,2-Diamino-4-nitrobenzene

* 3,4-Diaminonitrobenzene

* NCI-C03941

* 4NDB

* 4-Nitro-1,2-benzenediamine

* 4-Nitro-1,2-diaminobenzene

* 4-Nitro-1,2-fenylendiamin

* p-Nitro-o-phenylenediamine

* 4-Nitro-o-phenylene-diamine

* 4-Nitro-1,2-phenylenediamine

* 4-NO

* 4-Nop

* 4-Nopd

* 4-N-o-Pda







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








DOSE : 3 gm/kg


TOXIC EFFECTS :


REFERENCE :

SheCW# Personal Communication from C.W. Sheu, Genetic Toxicology Branch,

FDA, Mar. 25, 1977 Volume(issue)/page/year: 25MAR1977




DOSE : 2560 mg/kg


TOXIC EFFECTS :







REFERENCE :


(Alan






DOSE : 7680 mg/kg


TOXIC EFFECTS :


before birth)

REFERENCE :


(Alan



** MUTATION DATA **




REFERENCE :



7),1,1986




REFERENCE :



192,239,1987




REFERENCE :







REFERENCE :

MGBUA3 Microbial Genetics Bulletin. (Ohio State Univ., College of

Biological Science, Dept. of Microbiology, 484 W. 12th Ave., Columbus, OH

43210) No.1- 1950- Volume(issue)/page/year: 41,3,1976




REFERENCE :



95,191,1982





REFERENCE :



341,161,1995





REFERENCE :



56,31,1977




DOSE/DURATION : 1200 umol/L/3D

REFERENCE :



48,181,1977




REFERENCE :



78,243,1980


TEST SYSTEM : Mold - Aspergillus nidulans


REFERENCE :



97,293,1982




REFERENCE :



38,2621,1978




REFERENCE :


Baffins






REFERENCE :


E.


26,147,1995





REFERENCE :


E.


14,207,1989




REFERENCE :


E.


12(Suppl 13),37,1988




REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)





REFERENCE :


08736)





REFERENCE :



203,155,1988





REFERENCE :



343,157,1995




DOSE/DURATION : 3000 mg/kg/10W (Intermittent)

REFERENCE :

SheCW# Personal Communication from C.W. Sheu, Genetic Toxicology Branch,

FDA, Mar. 25, 1977 Volume(issue)/page/year: 25MAR1977




REFERENCE :

JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.





REFERENCE :

NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing

Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-





REFERENCE :


E.


27,67,1996




REFERENCE :



40,47,1976


TEST SYSTEM : Rodent - hamster Cells - not otherwise specified


REFERENCE :


08736)



TEST SYSTEM : Rodent - hamster Cells - not otherwise specified


REFERENCE :


08736)





REFERENCE :

GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring

St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:

27,95,1981




REFERENCE :



56,207,1977

*** REVIEWS ***



Chemicals


12210)




Chemicals


12210)






7,56,1987

TOXICOLOGY REVIEW

JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,

Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.

Discontinued.












EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; SHE-clonal assay

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-C3H/10T1/2



EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro

cytogenetics-nonhuman

EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; N

crassa-aneuploidy

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S

cerevisiae-reversion

EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Mammalian

micronucleus

EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast





47,26992,82







NITROPHENYLHYDRAZINE (4-)

RTECS NUMBER : MV8225000

CHEMICAL NAME : Hydrazine, (p-nitrophenyl)-








WISWESSER LINE NOTATION : ZMR DNW



* Hydrazine, (4-nitrophenyl)-

* p-Hydrazinonitrobenzene

* p-Nitrophenylhydrazine

* 4-Nitrophenylhydrazine







TOXIC EFFECTS :


specified



REFERENCE :





** MUTATION DATA **




REFERENCE :


Sangyo


160,





REFERENCE :



173,233,1986




NITROPHTHALIMIDE (4-)

RTECS NUMBER : TI5625000

CHEMICAL NAME : Phthalimide, 4-nitro-










* 1H-Isoindole-1,3(2H)-dione, 5-nitro-

* 4-Nitrophthalimide

* 5-Nitrophthalimide


** MUTATION DATA **




REFERENCE :


E.


11(Suppl 12),1,1988



NITROPROPANE (1-)

RTECS NUMBER : TZ5075000

CHEMICAL NAME : Propane, 1-nitro-








Human

Primary Irritant


* 1-Nitropropane

* 1-NP






DOSE/DURATION : 150 ppm/15M

REFERENCE :









TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - conjunctive irritation

REFERENCE :








TOXIC EFFECTS :


REFERENCE :

NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.

(National

Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair

Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)






TOXIC EFFECTS :


REFERENCE :

NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.

(National

Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair

Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)






TOXIC EFFECTS :


REFERENCE :


Pharmacie







TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Journal.







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :








TOXIC EFFECTS :


REFERENCE :



-,404,1986





TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **




REFERENCE :



221,263,1989

*** REVIEWS ***





TLV/BEI,1997





TLV/BEI,1997






3,188,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994









OEL-UNITED KINGDOM:TWA 25 ppm (90 mg/m3) JAN 1993

OEL-SWEDEN: NGV 5 ppm (18 mg/m3), TGV 10 ppm (35 mg/m3), JAN1999





NIOSH REL TO 1-NITROPROPANE-air:10H TWA 25 ppm

REFERENCE :























NITROPROPANE (2-)

RTECS NUMBER : TZ5250000

CHEMICAL NAME : Propane, 2-nitro-






WISWESSER LINE NOTATION : WNY1&1


Tumorigen

Mutagen


Human


* Dimethylnitromethane

* Isonitropropane

* Nipar S-20

* Nipar S-20 solvent

* Nipar S-30 solvent

* Nitroisopropane

* beta-Nitropropane

* 2-Nitropropane

* 2-NP








TOXIC EFFECTS :

Behavioral - anorexia (human)



REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :


Pharmacie






DOSE/DURATION : 10 gm/m3/2H

TOXIC EFFECTS :


REFERENCE :


Single


Projects,






TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :








TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :


Liver - tumors

REFERENCE :








TOXIC EFFECTS :


Liver - tumors

REFERENCE :




TYPE OF TEST : TC - Toxic concentration (other than lowest)



DOSE/DURATION : 207 ppm/26W-I

TOXIC EFFECTS :


Liver - tumors

REFERENCE :

XPHCI* U.S. Public Health Service, Current Intelligence Bulletin.

(National

Institute for Occupational Safety and Health, 5600 Fishers Lane,

Rockville,

MD 20857) Volume(issue)/page/year: 25APR1977





DOSE : 2550 mg/kg


TOXIC EFFECTS :



REFERENCE :



48,A35,1979




DOSE : 2550 mg/kg


TOXIC EFFECTS :





REFERENCE :

SWEHDO Scandinavian Journal of Work, Environment and Health.

(Haartmaninkatu

1, SF-00290 Helsinki, 29, Finland) V.1- 1975-


7(Suppl 4),66,1981

** MUTATION DATA **




REFERENCE :







REFERENCE :



1),3,1983




REFERENCE :



104,49,1982




REFERENCE :


Sangyo


160,





REFERENCE :



190,217,1987




REFERENCE :



190,217,1987





REFERENCE :








REFERENCE :







REFERENCE :








REFERENCE :


Ireland


57,61,1991





REFERENCE :



391,165,1997




REFERENCE :



221,263,1989





REFERENCE :








REFERENCE :







REFERENCE :



413,69,1998

*** REVIEWS ***





TLV/BEI,1997





TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)






7,56,1987






3,188,1971



Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994






OEL-THE NETHERLANDS:TWA 1 ppm (3.6 mg/m3);STEL 2 ppm (7.2 mg/m3) JAN 1993


OEL-SWEDEN:TWA 10 ppm (35 mg/m3) JAN 1993

OEL-SWITZERLAND:TWA 5 ppm (18 mg/m3);Carcinogen JAN 1993







NIOSH REL TO 2-NITROPROPANE-air:CA lowest feasible conc.

REFERENCE :

























NIOSH CURRENT INTELLIGENCE BULLETIN 17, 1977

NIOSH Analytical Method, 1994: 2-Nitropropane, 2528


Human Carcinogen


OSHA ANALYTICAL METHOD #15, SUPERSEDED BY #46

NITROQUINOLINE (5-)

RTECS NUMBER : VC1850000

CHEMICAL NAME : Quinoline, 5-nitro-








WISWESSER LINE NOTATION : T66 BNJ GNW



* 5-Nitroquinoline


** MUTATION DATA **




REFERENCE :



92,29,1982




REFERENCE :



35,521,1975




NITROSODIMETHYLANILINE (4-)

RTECS NUMBER : BX7175000

CHEMICAL NAME : Aniline, N,N-dimethyl-p-nitroso-








WISWESSER LINE NOTATION : ONR DN1&1


Mutagen


* Accelerine

* Benzenamine, N,N-dimethyl-4-nitroso-

* p-(Dimethylamino)nitrosobenzene

* 4-(Dimethylamino)nitrosobenzene

* N,N-Dimethyl-p-nitrosoaniline

* N,N-Dimethyl-4-nitrosobenzenamine

* Dimethyl(p-nitrosophenyl)amine

* NCI-C01821

* NDMA

* p-Nitroso-N,N-dimethylaniline

* 4-Nitrosodimethylaniline

* Paranitrosodimethylanilide

* Ultra Brilliant Blue P







TOXIC EFFECTS :



Kidney, Ureter, Bladder - hematuria

REFERENCE :

JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35.

For

publisher information, see AEHLAU. Volume(issue)/page/year: 13,87,1931






TOXIC EFFECTS :


Gastrointestinal - tumors


REFERENCE :

PUOMA5 Proceedings of the University of Otago Medical School. (Otago

Medical School Research Soc., Box 913, Dunedin, New Zealand) V.1-

1922-


** MUTATION DATA **




REFERENCE :



7),1,1986



NITROSODIPHENYLAMINE (4-)

RTECS NUMBER : JK0175000

CHEMICAL NAME : Diphenylamine, 4-nitroso-








WISWESSER LINE NOTATION : ONR DMR


Mutagen

Primary Irritant


* Benzenamine, 4-nitroso-N-phenyl-

* Naugard TKB

* NCI-C02244

* p-Nitrosodifenylamin

* p-Nitrosodiphenylamine

* 4-Nitrosodiphenylamine

* p-Nitroso-N-phenylaniline

* 4-Nitroso-N-phenylaniline

* 4-Nitroso-N-phenylbenzenamine

* N-Phenyl-p-nitrosoaniline

* TKB








REFERENCE :



-,758,1986






TOXIC EFFECTS :


REFERENCE :


Systems


21010)







TOXIC EFFECTS :


Liver - tumors

REFERENCE :


Chemicals


12210)






TOXIC EFFECTS :


Liver - tumors

REFERENCE :








TOXIC EFFECTS :


Liver - tumors

REFERENCE :








TOXIC EFFECTS :


Liver - tumors

REFERENCE :








TOXIC EFFECTS :


Liver - tumors

REFERENCE :








TOXIC EFFECTS :


Liver - tumors

REFERENCE :


Chemicals


12210)






TOXIC EFFECTS :


Liver - tumors

REFERENCE :


Chemicals


12210)






TOXIC EFFECTS :


Liver - tumors

REFERENCE :


Chemicals


12210)


** MUTATION DATA **




REFERENCE :



1),3,1983




REFERENCE :


E.


12(Suppl 13),37,1988




REFERENCE :



89,95,1981




REFERENCE :


E.


12(Suppl 13),103,1988

*** REVIEWS ***



Chemicals


12210)




Chemicals


12210)






7,56,1987




NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat




NITROSONAPHTHOL (1:2-)


CHEMICAL NAME : 2-Naphthol, 1-nitroso-








WISWESSER LINE NOTATION : L66J BNO CQ


Mutagen


* C.I. 10000

* alpha-Nitroso-beta-naftol

* 1-Nitroso-2-naftol

* Nitroso-beta-naphthol

* alpha-Nitroso-beta-naphthol

* 1-Nitroso-2-naphthol

* Zelen moridlova 4







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :




6,160,1952

** MUTATION DATA **




REFERENCE :






REFERENCE :

JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center

for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)

V.19-




















NITROSONAPHTHOL (2,1-)


CHEMICAL NAME : 1-Naphthol, 2-nitroso-








WISWESSER LINE NOTATION : L66J BQ CNO



* 2-Nitroso-1-naphthol







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :



Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :


V.1-60,



41,985,1968




NITROSTYRENE (BETA-)

RTECS NUMBER : WL5450000

CHEMICAL NAME : Styrene, beta-nitro-








WISWESSER LINE NOTATION : WN1U1R


* Benzene, (2-nitroethenyl)-

* NCI-C02211

* beta-Nitrostyrene

* gamma-Nitrostyrene

* (2-Nitrovinyl)benzene







TOXIC EFFECTS :


REFERENCE :



NJ






NITROSTYRENE (TRANS,BETA-)

RTECS NUMBER : WL5460000

CHEMICAL NAME : Styrene, beta-nitro-, (E)-










* Benzene, (2-nitroethenyl)-, (E)-

* (E)-(2-Nitroethenyl)benzene

* (E)-beta-Nitrostyrene

* trans-beta-Nitrostyrene







TOXIC EFFECTS :


REFERENCE :

CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For

publisher information, see EJMCA5. Volume(issue)/page/year: 6,186,1971

NITROTOLUENE (2-)

RTECS NUMBER : XT3150000

CHEMICAL NAME : Toluene, o-nitro-







WISWESSER LINE NOTATION : WNR B1


Mutagen



* Benzene, 1-methyl-2-nitro-

* o-Methylnitrobenzene

* 1-Methyl-2-nitrobenzene

* 2-Methylnitrobenzene

* o-Nitrotoluene

* 2-Nitrotoluene

* o-Nitrotoluene

* ortho-Nitrotoluol

* 2-Nitrotoluol

* ONT







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS



REFERENCE :









TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :




REFERENCE :










TOXIC EFFECTS :



Related to Chronic Data - changes in testicular weight

REFERENCE :


Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3346





TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - olfactory nerve change



REFERENCE :







TOXIC EFFECTS :


REFERENCE :


New







TOXIC EFFECTS :


Reproductive - Tumorigenic effects - other reproductive system tumors

REFERENCE :







DOSE : 32123 mg/kg


TOXIC EFFECTS :




REFERENCE :






DOSE : 69154 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :






DOSE : 140 gm/kg


TOXIC EFFECTS :



REFERENCE :



** MUTATION DATA **





REFERENCE :


Ireland


51,131,1984





REFERENCE :



43,2836,1983




REFERENCE :


E.


26,147,1995




REFERENCE :


E.


10(Suppl 10),1,1987

*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)




Chemicals


12210)





Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994






OEL-SWEDEN: NGV 1nppm (6 mg/m3), KTV 2 ppm (11 mg/m3), Skin, JAN1999





NIOSH REL TO o-NITROTOLUENE-air:10H TWA 2 ppm (Sk)

REFERENCE :















NTP Toxicity studies, RPT# TOX-23, May 1999



NITROTOLUENE (4-)


CHEMICAL NAME : Toluene, p-nitro-






WISWESSER LINE NOTATION : WNR D1


Mutagen




* p-Methylnitrobenzene



* NCI-C60537

* 4-Nitrotoluene

* p-Nitrotoluene

* para-Nitrotoluol

* 4-Nitrotoluol

* PNT







TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :

Behavioral - ataxia



REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :




REFERENCE :










TOXIC EFFECTS :





REFERENCE :







TOXIC EFFECTS :



REFERENCE :







TOXIC EFFECTS :




REFERENCE :


New






DOSE : 65793 mg/kg


TOXIC EFFECTS :




REFERENCE :






DOSE : 30 mg/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :




** MUTATION DATA **




REFERENCE :






REFERENCE :



170,11,1986




REFERENCE :


E.


26,147,1995




REFERENCE :


E.


10(Suppl 10),1,1987




REFERENCE :


E.


10(Suppl 10),1,1987

*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)




Chemicals


12210)





Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994












NIOSH REL TO p-NITROTOLUENE-air:10H TWA 2 ppm (Sk)

REFERENCE :


















NITROTOLUENE (META-)


CHEMICAL NAME : Toluene, m-nitro-






WISWESSER LINE NOTATION : WNR C1


Mutagen




* m-Methylnitrobenzene



* MNT

* m-Nitrotoluene

* 3-Nitrotoluene

* m-Nitrotoluene

* meta-Nitrotoluol

* 3-Nitrotoluol







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :


REFERENCE :

CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012,

Columbus,

OH 43210) V.1- 1907- Volume(issue)/page/year: 73,91015e,1970





TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :




REFERENCE :









TOXIC EFFECTS :


REFERENCE :

CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012,

Columbus,

OH 43210) V.1- 1907- Volume(issue)/page/year: 73,91015e,1970






TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :



REFERENCE :


New






TOXIC EFFECTS :



REFERENCE :









DOSE : 31122 mg/kg


TOXIC EFFECTS :


REFERENCE :






DOSE : 60151 mg/kg


TOXIC EFFECTS :




REFERENCE :



** MUTATION DATA **




REFERENCE :


E.


10(Suppl 10),1,1987

*** REVIEWS ***





TLV/BEI,1997



Chemicals


12210)




Chemicals


12210)




Chemicals


12210)





Supt.


29,1910.1000,1994



Supt.


29,1926.55,1994



Supt.


29,1915.1000,1993



Supt.


41,50-204.50,1994






OEL-FRANCE: VME 2 ppm (11 mg/m3), Skin, JAN1999







NIOSH REL TO m-NITROTOLUENE-air:10H TWA 2 ppm (Sk)

REFERENCE :









NTP Carcinogenesis studies; laboratory assigned, May 1999

NIVALENOL

RTECS NUMBER : YD0165000

CHEMICAL NAME : Trichothec-9-en-8-one,

12,13-epoxy-3,4,7,15-tetrahydroxy-,

(3-alpha,4-beta,7-alpha)-







WISWESSER LINE NOTATION : T C665 A AX EV IO FUTJ B1 C1Q DQ F1 KQ LQ A-&

BT3OX

CHJ


Mutagen

Natural Product

Primary Irritant


* 12,13-Epoxy-3,4,7,15-tetrahydroxytrichothec-9-en-8-one

* Nivalenol

* 3-alpha,4-beta,7-alpha,15-Tetrahydroxy-12,13-epoxytrichothec-9-en-8-one

* 3-alpha,4-beta,7-alpha,15-Tetrahydroxyscirp-9-en-8-one

* Trichothec-9-en-8-one,

12,13-epoxy-3-alpha,4-beta,7-alpha,15-tetrahydroxy-






DOSE/DURATION : 3124 ng


REFERENCE :



see TOSCF2 Volume(issue)/page/year: 4,S124,1984






TOXIC EFFECTS :


REFERENCE :

SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon

Shokuhin

Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo

150, Japan) V.1- 1960- Volume(issue)/page/year: 31,144,1990





TOXIC EFFECTS :


REFERENCE :

SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon

Shokuhin

Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo

150, Japan) V.1- 1960- Volume(issue)/page/year: 31,144,1990





TOXIC EFFECTS :


REFERENCE :

DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc.,

52



4,135,1983





TOXIC EFFECTS :


REFERENCE :

ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15

Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-






TOXIC EFFECTS :




REFERENCE :



28,2393,1968





TOXIC EFFECTS :


REFERENCE :

JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya

Book-Stores

of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581

Webster St., San Francisco, CA 94115) V.7- 1928-


42,91,1972





TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from small intestine


REFERENCE :



see TOSCF2 Volume(issue)/page/year: 4,S124,1984






TOXIC EFFECTS :





REFERENCE :


House,



27,585,1989





TOXIC EFFECTS :





REFERENCE :


House,



27,585,1989





TOXIC EFFECTS :



REFERENCE :








TOXIC EFFECTS :


Blood - leukopenia

REFERENCE :








TOXIC EFFECTS :



REFERENCE :

JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya

Book-Stores

of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581

Webster St., San Francisco, CA 94115) V.7- 1928-


40,33,1970

** MUTATION DATA **





REFERENCE :



415,191,1998





REFERENCE :



415,191,1998




REFERENCE :

EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,

Switzerland) V.1- 1945- Volume(issue)/page/year: 24,1032,1968




REFERENCE :



415,191,1998

*** REVIEWS ***



Chemicals


12210)


TOXICOLOGY REVIEW



26,225,1974

TOXICOLOGY REVIEW

NUREA8 Nutrition Reviews. (Springer-Verlag New York, Inc., Service

Center,

44 Hartz Way, Secaucus, NJ 07094) V.1- 1942-


31,169,1973

NONACHLOR (TRANS-)

RTECS NUMBER : PC0950000

CHEMICAL NAME : 4,7-Methano-1H-indene,

1,2,3,4,5,6,7,8,8-nonachlor-2,3,3a,4,7,7a-hexahydro-,

(1-alpha,2-beta,

3-alpha,3a-alpha,4-beta,7-beta,7a-alpha)-





MOLECULAR FORMULA : C10-H5-Cl9




* trans-Nonachlor







TOXIC EFFECTS :


REFERENCE :






NONANOIC ACID

RTECS NUMBER : RA6650000

CHEMICAL NAME : Nonanoic acid








WISWESSER LINE NOTATION : QV8



* Cirrasol 185A

* Emfac 1202

* Hexacid C-9

* n-Nonoic acid

* n-Nonylic acid

* Pelargic acid

* 1-Octanecarboxylic acid

* Pelargonic acid








REFERENCE :


For







REFERENCE :

EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati,

OH

45232) Volume(issue)/page/year: S3B,-,1964




DOSE/DURATION : 100%


REFERENCE :


For







TOXIC EFFECTS :


REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:

18,141,1961

*** REVIEWS ***

TOXICOLOGY REVIEW


1955-60.


21,100,1960




















NONIDET P-40

RTECS NUMBER : RI0175000

CHEMICAL NAME : Octyl phenol condensed with 3 moles ethylene oxide




MOLECULAR FORMULA : (C2-H4-O)n.C14-H22-O



* Octylphenol EO (3)

* OPE-3








REFERENCE :

PSTGAW Proceedings of the Scientific Section of the Toilet Goods

Association. (Washington, DC) No.1-48, 1944-67. Discontinued.






DOSE/DURATION : 4 mL/kg

TOXIC EFFECTS :


REFERENCE :

PSTGAW Proceedings of the Scientific Section of the Toilet Goods

Association. (Washington, DC) No.1-48, 1944-67. Discontinued.




















NONOXYNOL (9-)

RTECS NUMBER : MD0906000

CHEMICAL NAME : Glycols, polyethylene, mono(p-nonylphenyl) ether



12612-63-4



MOLECULAR FORMULA : (C2-H4-O)n-C15-H24-O

WISWESSER LINE NOTATION : /*O2*/ *9R D **Q




* Nonylphenoxypoly(ethyleneoxy)ethanol

* NP-9

* Phenol, p-nonyl-, monoether with polyethylene glycol

* N-9

* Nonoxynol-9







TOXIC EFFECTS :


REFERENCE :


V.1-







TOXIC EFFECTS :




REFERENCE :



35,277,1987



ROUTE OF EXPOSURE : Intrauterine


DOSE : 2500 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-



ROUTE OF EXPOSURE : Intrauterine


DOSE : 5 mg/kg


TOXIC EFFECTS :




REFERENCE :


V.1-



ROUTE OF EXPOSURE : Intravaginal


DOSE : 50 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 50 mg/kg


TOXIC EFFECTS :



REFERENCE :






DOSE : 1250 ug/kg


TOXIC EFFECTS :


REFERENCE :


S,





DOSE : 1 mg/kg


TOXIC EFFECTS :



REFERENCE :


V.1-


** MUTATION DATA **




REFERENCE :













NOHS Hazard Code - T0292
















NONYL ALDEHYDE

RTECS NUMBER : RA5700000

CHEMICAL NAME : 1-Nonanal








WISWESSER LINE NOTATION : VH8


Natural Product

Primary Irritant


* Aldehyde C-9

* C-9 aldehyde

* NCI-C61018

* 1-Nonaldehyde

* Nonanal

* 1-Nonyl aldehyde

* Pelargonic aldehyde








REFERENCE :


For





DOSE/DURATION : 100 uL


REFERENCE :









TOXIC EFFECTS :



REFERENCE :




TYPE OF TEST : LC - Lethal concentration




TOXIC EFFECTS :




REFERENCE :








TOXIC EFFECTS :


REFERENCE :









TOXIC EFFECTS :




REFERENCE :




** MUTATION DATA **




REFERENCE :



290,183,1993




REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

4,277,1989




















NIOSH Analytical Method, 1996: Volatile organic compound, 2549

NONYLPHENOL (4-)


CHEMICAL NAME : Phenol, p-nonyl-









* p-Nonylphenol

* p-n-Nonylphenol

* 4-Nonylphenol

* para-Nonylphenol

* Phenol, 4-nonyl-







TOXIC EFFECTS :


REFERENCE :

















NONYLPHENOL (N,4-)


CHEMICAL NAME : Phenol, 4-nonyl-, branched







Primary Irritant


* Nonylphenol

* p-Nonylphenol, branched








REFERENCE :


Toxicology,


V.1-







REFERENCE :


Toxicology,


V.1-







TOXIC EFFECTS :


Blood - hemorrhage


REFERENCE :


Toxicology,


V.1-






TOXIC EFFECTS :




REFERENCE :


Toxicology,


V.1-







TOXIC EFFECTS :

Behavioral - wakefulness


REFERENCE :








DOSE : 4400 mg/kg

SEX/DURATION : multigeneration

TOXIC EFFECTS :


gain)

Reproductive - Effects on Newborn - physical

REFERENCE :







NORADRENALINE

RTECS NUMBER : DN5950000

CHEMICAL NAME : Benzyl alcohol,

alpha-(aminomethyl)-3,4-dihydroxy-,

(-)-







WISWESSER LINE NOTATION : Z1YQR CQ DQ -L


Mutagen



* Adrenor

* Aktamin

* l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol

* (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol

* l-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol

* (-)-alpha-(Aminomethyl)protocatechuyl alcohol

* Arterenol

* l-Arterenol

* 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-

* l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol

* l-3,4-Dihydroxyphenylethanolamine

* Levarterenol

* Levoarterenol

* Levonoradrenaline

* Levonorepinephrine

* Levophed

* (-)-Noradrec

* Noradrenalin

* Noradrenalina

* Noradrenaline

* (-)-Noradrenaline

* D-(-)-Noradrenaline

* l-Noradrenaline

* Noradrenline

* Norartrinal

* Norepinephrine

* (-)-Norepinephrine

* l-Norepinephrine

* L-Norepinephrine

* Norepirenamine

* Sympathin E







TOXIC EFFECTS :




REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:

31,49,1972





TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3,

D-1000


56,615,1969





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.

(Heymans

Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-






DOSE : 8 mg/kg


TOXIC EFFECTS :


REFERENCE :

JCPPAV Journal of Comparative and Physiological Psychology. (Washington,

DC) V.40-96, 1947-82. Volume(issue)/page/year: 58,309,1964




DOSE : 60 ug/kg


TOXIC EFFECTS :


REFERENCE :

DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub.,

Inc.,

79 Fifth Ave., New York, NY 10003) V.1- 1980-


7(Suppl 1),72,1984




DOSE : 16 mg/kg


TOXIC EFFECTS :


REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-

Volume(issue)/page/year: 45(Suppl),viii,1969




DOSE : 10 ug/kg


TOXIC EFFECTS :


Vascular - measurement of regional blood flow



REFERENCE :


Depot,






DOSE : 2 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - hepatobiliary system

REFERENCE :


(Alan


Volume(issue)/page/year: 9,A19,1974




DOSE : 2 mg/kg


TOXIC EFFECTS :




REFERENCE :


(Alan



** MUTATION DATA **



TEST SYSTEM : Insect - silkworm


REFERENCE :

ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72.





REFERENCE :



40,1414,1980


TEST SYSTEM : Rodent - rat Lung


REFERENCE :


5050,






REFERENCE :



40,1414,1980
















NORADRENALINE HYDROCHLORIDE


CHEMICAL NAME : Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-,

hydrochloride, (-)-




MOLECULAR FORMULA : C8-H11-N-O3.Cl-H


WISWESSER LINE NOTATION : Z1YQR CQ DQ &GH



* Aktamin hydrochloride

* l-Arterenol hydrochloride

* Levophed hydrochloride

* Noradrenaline hydrochloride

* Nor-adrenalin hydrochloride

* Norepinephrine hydrochloride

* (-)-Norepinephrine hydrochloride







TOXIC EFFECTS :


REFERENCE :


(Heymans







TOXIC EFFECTS :


REFERENCE :


(Heymans




ROUTE OF EXPOSURE : Intraduodenal



TOXIC EFFECTS :


REFERENCE :


(Heymans







TOXIC EFFECTS :


REFERENCE :


&



NORADRENALINE HYDROCHLORIDE (DL-)


CHEMICAL NAME : Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-,

hydrochloride-, (+-)-




MOLECULAR FORMULA : C8-H11-N-O3.Cl-H


WISWESSER LINE NOTATION : Z1YQR CQ DQ &GH -R




* dl-Arterenol hydrochloride

* 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, hydrochloride, (+-)-

* (+-)-Noradrenaline hydrochloride

* dl-Noradrenaline hydrochloride

* (+-)-Norepinephrine hydrochloride

* dl-Norepinephrine hydrochloride

* DL-Norepinephrine hydrochloride







TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


Vascular - regional or general arteriolar constriction

Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :


&







DOSE : 13 mg/kg


TOXIC EFFECTS :


REFERENCE :

NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.

(Nippon

Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,

Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-


85,79,1985




DOSE : 3200 ng/kg


TOXIC EFFECTS :


REFERENCE :

PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA

94022)


NORBORNANEMETHANOL ENDO AND EXO (2-)

RTECS NUMBER : RB7350000

CHEMICAL NAME : 2-Norbornanemethanol








WISWESSER LINE NOTATION : L55 ATJ C1Q


Primary Irritant


* CC 1207

* CPC 1207

* EC-1207

* Experimental chemotherapeutant 1,207

* 2-Hydroxymethylbicyclo(2.2.1)heptane

* 2-Hydroxymethylnorcamphane

* 2-Norcamphane methanol

* 2-Norcamphanylmethanol

* 2-Norkamfanylmethanol








REFERENCE :



23,95,1962






REFERENCE :



-,214,1986




DOSE/DURATION : 250 ug/24H


REFERENCE :



-,214,1986






TOXIC EFFECTS :


REFERENCE :

28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College

Science Pub., 1969 Volume(issue)/page/year: 4,302,1969





TOXIC EFFECTS :


REFERENCE :



23,95,1962



NORETHINDRONE

RTECS NUMBER : RC8975000

CHEMICAL NAME : 19-Nor-17-alpha-pregn-4-en-20-yn-3-one,

17-hydroxy-








WISWESSER LINE NOTATION : L E5 B666 OV MUTJ E FQ F1UU1 -A&F


Drug

Mutagen


Human

Hormone


* Anhydrohydroxynorprogesterone

* 17-alpha-Ethinylestra-4-en-17-beta-ol-3-one

* 17-alpha-Ethinyl-17-beta-hydroxy-delta(sup:4)-estren-3-one

* Ethinylnortestosterone

* Ethinyl-19-nortestosterone

* 17-Ethinyl-19-nortestosterone

* 17-alpha-Ethinyl-19-nortestosterone

* 17-alpha-Ethynyl-4-estren-17-ol-3-one

* 17-alpha-Ethynyl-17-hydroxy-4-estren-3-one

* 17-alpha-Ethynyl-17-beta-hydroxyestr-4-en-3-one

* 17-alpha-Ethynyl-17-beta-hydroxy-4-estren-3-one

* 17-alpha-Ethynyl-17-beta-hydroxy-19-norandrost-4-en-3-one

* 17-alpha-Ethynyl-19-norandrost-4-en-17-beta-ol-3-one

* 17-alpha-Ethynyl-19-nor-4-androsten-17-beta-ol-3-one

* 17-alpha-Ethynyl-19-nortestosterone

* Gestest

* (17-alpha)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one

* 17-Hydroxy-17-alpha-19-norpregn-4-en-20-yn-3-one

* 17-Hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one

* 17-beta-Hydroxy-19-norpregn-4-en-20-yn-3-one

* Micronett

* Micronor

* Noralutin

* Norethindrone

* 19-Nor-ethindrone

* 19-Norethinyltestosterone

* 19-Nor-ethinyl--4,5-testosterone

* Norethisteron

* Norethisterone

* 19-Norethisterone

* Norethynodron

* Norethynodrone

* 19-Nor-17-alpha-ethynylandrosten-17-beta-ol-3-one

* 19-Nor-17-alpha-ethynyl-17-beta-hydroxy-4-androsten-3-one

* 19-Nor-17-ethinyltestosterone

* 19-Nor-17-alpha-ethynyltestosterone

* Norlutin

* Norluton

* Norpregneninlone

* 17-alpha-19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-

* Nor-Q.D.

* Primolut-N

* Proluteasi

* SC 4640

* Triella







TOXIC EFFECTS :

Endocrine - androgenic


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :



REFERENCE :

SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China

International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)

1980-







TOXIC EFFECTS :



REFERENCE :




21,153,1967





TOXIC EFFECTS :



REFERENCE :

PMDFA9 Pakistan Medical Forum. (Karachi, Pakistan) V.1-8, 1966-73(?)

Disc

ontinued. Volume(issue)/page/year: 7,21,1972





TOXIC EFFECTS :


Tumorigenic - increased incidence of tumors in susceptible strains

REFERENCE :


08736)






DOSE : 4 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 7143 ug/kg


TOXIC EFFECTS :



Reproductive - Paternal Effects - impotence


REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E,

DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

37,75,1961




DOSE : 4200 ug/kg


TOXIC EFFECTS :



REFERENCE :



124,891,1956




DOSE : 37800 ug/kg


TOXIC EFFECTS :


REFERENCE :

JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams &

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952-





DOSE : 210 ug/kg


TOXIC EFFECTS :




REFERENCE :

OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52



41,585,1973




DOSE : 18 mg/kg


TOXIC EFFECTS :





REFERENCE :







DOSE : 18 mg/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - breast development

REFERENCE :







DOSE : 28 mg/kg


TOXIC EFFECTS :


REFERENCE :

AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn

St.,

Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-





DOSE : 63 mg/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 2190 ug/kg


TOXIC EFFECTS :


REFERENCE :

ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica,

Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948-





DOSE : 7 ug/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - postpartum

REFERENCE :







DOSE : 37800 ug/kg


TOXIC EFFECTS :


REFERENCE :

JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams &

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952-





DOSE : 230 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 131 ug/kg


TOXIC EFFECTS :


REFERENCE :


V.1-





DOSE : 4200 ug/kg


TOXIC EFFECTS :



REFERENCE :

NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10

Shattuck St., Boston, MA 02115) V.198- 1928-


268,255,1963




DOSE : 14 mg/kg


TOXIC EFFECTS :


REFERENCE :


S,





DOSE : 12 mg/kg


TOXIC EFFECTS :


REFERENCE :



211,1171,1981




DOSE : 76 mg/kg


TOXIC EFFECTS :


REFERENCE :

PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,

Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 26,151,1960




DOSE : 84 ug/kg


TOXIC EFFECTS :


REFERENCE :


S,





DOSE : 50 mg/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 28 mg/kg


TOXIC EFFECTS :


accessory glands

REFERENCE :

ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of

Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-





DOSE : 188 mg/kg


TOXIC EFFECTS :




appendages


REFERENCE :

IJEBA6 Indian Journal of Experimental Biology. (Publications &

Information

Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-





DOSE : 100 mg/kg


TOXIC EFFECTS :


REFERENCE :

ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030,

Tokyo International, Tokyo, Japan) V.1- 1954-


24,77,1977




DOSE : 20 mg/kg


TOXIC EFFECTS :



REFERENCE :






DOSE : 50 mg/kg


TOXIC EFFECTS :



REFERENCE :


Preston


59,695,1956




DOSE : 60 mg/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 17500 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 400 ug/kg


TOXIC EFFECTS :


REFERENCE :



1903/04-





DOSE : 2 mg/kg


TOXIC EFFECTS :



REFERENCE :






DOSE : 15 mg/kg


TOXIC EFFECTS :


REFERENCE :



1903/04-





DOSE : 17500 ug/kg


TOXIC EFFECTS :


REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E,

DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

38,128,1961




DOSE : 500 ug/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 15750 ug/kg


TOXIC EFFECTS :



accessory glands

REFERENCE :



1903/04-





DOSE : 5250 ug/kg


TOXIC EFFECTS :

Reproductive - Fertility - male fertility index (e.g. # males impregnating

females per # males exposed to fertile nonpregnant females)

REFERENCE :


V.1-





DOSE : 62500 ug/kg


TOXIC EFFECTS :



REFERENCE :


Preston


78,965,1966




DOSE : 1500 ug/kg


TOXIC EFFECTS :


REFERENCE :

RPHRA6 Recent Progress In Hormone Research. Proceedings of the

Laurentian

Hormone Conference. (Academic Press, Inc., 1 E. First St., Duluth, MN

55802)





DOSE : 80 mg/kg


TOXIC EFFECTS :




REFERENCE :



1903/04-





DOSE : 200 mg/kg


TOXIC EFFECTS :



REFERENCE :






DOSE : 360 ug/kg


TOXIC EFFECTS :


REFERENCE :



1903/04-





DOSE : 2 mg/kg


TOXIC EFFECTS :



REFERENCE :






DOSE : 50 mg/kg


TOXIC EFFECTS :



REFERENCE :


Depot,






DOSE : 120 ug/kg


TOXIC EFFECTS :


REFERENCE :



1903/04-





DOSE : 12 mg/kg


TOXIC EFFECTS :


before birth)


REFERENCE :







DOSE : 6500 ug/kg


TOXIC EFFECTS :



REFERENCE :


(Alan






DOSE : 6400 ng/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 30 ug/kg/30M


TOXIC EFFECTS :




REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

22,935,1980




DOSE : 18 ug/kg


TOXIC EFFECTS :


REFERENCE :


08736)





DOSE : 34 ug/kg


TOXIC EFFECTS :


REFERENCE :


08736)





DOSE : 3 mg/kg


TOXIC EFFECTS :


REFERENCE :

BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309

W.

Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:

30,886,1984




DOSE : 800 ug/kg


TOXIC EFFECTS :


REFERENCE :


S,

Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year:

39(Suppl),419,1983




DOSE : 186 ug/kg


TOXIC EFFECTS :

Reproductive - Fertility - abortion

REFERENCE :


V.1-





DOSE : 270 ug/kg


TOXIC EFFECTS :




REFERENCE :


S,





DOSE : 2847 ug/kg


TOXIC EFFECTS :


REFERENCE :


V.1-





DOSE : 39 mg/kg


TOXIC EFFECTS :




REFERENCE :



1903/04-





DOSE : 150 ug/kg


TOXIC EFFECTS :


REFERENCE :

13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA,

1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961





DOSE : 125 ug/kg


TOXIC EFFECTS :


REFERENCE :

85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,

1965 Volume(issue)/page/year: -,57,1965




DOSE : 313 ug/kg


TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive females

per # females mated; # copulations per # estrus cycles)

REFERENCE :







DOSE : 500 ug/kg


TOXIC EFFECTS :



REFERENCE :

STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA

94609)





DOSE : 500 ug/kg


TOXIC EFFECTS :


REFERENCE :

STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA

94609)





DOSE : 1250 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 2500 ug/kg


TOXIC EFFECTS :


REFERENCE :

ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,

NY

10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962




DOSE : 15 mg/kg


TOXIC EFFECTS :



REFERENCE :


Depot,






DOSE : 37500 ng/kg


TOXIC EFFECTS :




REFERENCE :







DOSE : 5 mg/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 300 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 86 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - endocrine system


REFERENCE :


S,





DOSE : 2400 ug/kg


TOXIC EFFECTS :




REFERENCE :


Depot,



** MUTATION DATA **




REFERENCE :



1903/04-





DOSE/DURATION : 600 mg/kg/6W (Continuous)

REFERENCE :



419,33,1998




REFERENCE :







REFERENCE :







DOSE/DURATION : 45 mg/kg/15D (Continuous)

REFERENCE :



300,215,1993




REFERENCE :







REFERENCE :





TEST SYSTEM : Mammal - species unspecified Cells - not otherwise

specified


REFERENCE :





TEST SYSTEM : Mammal - species unspecified Cells - not otherwise

specified


REFERENCE :




*** REVIEWS ***





7,294,1987

TOXICOLOGY REVIEW

COGYAK Clinical Obstetrics and Gynecology. (Lippincott/Harper, Journal


1958-


TOXICOLOGY REVIEW

PCNAA8 Pediatric Clinics of North America. (W.B. Saunders Co., W.

Washington Sq., Philadelphia, PA 19105) V.1- 1954-


TOXICOLOGY REVIEW

ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75.

For

publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

TOXICOLOGY REVIEW

CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a

High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year:

4,309,1976

TOXICOLOGY REVIEW





EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Sperm

morphology-human


Human Carcinogen

NORFLOXACIN

RTECS NUMBER : VB2005000

CHEMICAL NAME : 3-Quinolinecarboxylic acid,

1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-






MOLECULAR FORMULA : C16-H18-F-N3-O3


WISWESSER LINE NOTATION : T66 BN EVJ B2 DVQ HF I- DT6M DNTJ


Mutagen


Human


* AM-715

* Baccidal

*

1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxyl

ic acid

*

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxyl

ic acid

* MK-366

* Norfloxacin







TOXIC EFFECTS :




REFERENCE :


Ltd.,







TOXIC EFFECTS :

Musculoskeletal - other changes

REFERENCE :

NZMJAX New Zealand Medical Journal. (New Zealand Medical Assoc., P.O.

Box

156, Wellington, New Zealand) V.1- 1900- Volume(issue)/page/year:

96,590,1983





TOXIC EFFECTS :



Musculoskeletal - joints

REFERENCE :


Ltd.,







TOXIC EFFECTS :


REFERENCE :


Tokyo,






TOXIC EFFECTS :


REFERENCE :


Tokyo,






TOXIC EFFECTS :



REFERENCE :


Kamiosaki,


29(Suppl 4),766,1981





TOXIC EFFECTS :



REFERENCE :


Kamiosaki,


29(Suppl 4),766,1981





TOXIC EFFECTS :


REFERENCE :



DC






TOXIC EFFECTS :


REFERENCE :

ENSHEE Ensho. Japanese Journal of Inflammation. (The Japanese Society of

Inflammation, 4-5-505 Iidabashi, 4-Chrome, Chiyoda-ku, Tokyo 102, Japan)






TOXIC EFFECTS :


REFERENCE :


Tokyo,






TOXIC EFFECTS :



REFERENCE :


Kamiosaki,


29(Suppl 4),766,1981





TOXIC EFFECTS :


REFERENCE :


Kamiosaki,


29(Suppl 4),766,1981





TOXIC EFFECTS :


REFERENCE :



DC







TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - retinal changes (pigmentary

depositions, retinitis, other)

REFERENCE :








TOXIC EFFECTS :

Musculoskeletal - joints

REFERENCE :







DOSE : 1375 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 2750 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 20 gm/kg



conception

TOXIC EFFECTS :




REFERENCE :


Kamiosaki,


29(Suppl 4),886,1981




DOSE : 10 gm/kg



conception

TOXIC EFFECTS :



REFERENCE :


Kamiosaki,


29(Suppl 4),886,1981




DOSE : 1250 mg/kg


TOXIC EFFECTS :


REFERENCE :


Kamiosaki,


29(Suppl 4),895,1981




DOSE : 2 gm/kg


TOXIC EFFECTS :


Endocrine - estrogenic



REFERENCE :


(Alan






DOSE : 4650 mg/kg


TOXIC EFFECTS :


REFERENCE :


(Alan






DOSE : 1625 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 1300 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 1300 mg/kg


TOXIC EFFECTS :





REFERENCE :


(Alan






DOSE : 1300 mg/kg


TOXIC EFFECTS :


before birth)




REFERENCE :




** MUTATION DATA **




REFERENCE :







REFERENCE :







REFERENCE :







REFERENCE :







REFERENCE :







REFERENCE :



211,171,1989





REFERENCE :



312,127,1994




REFERENCE :



221,263,1989

NORFLUDIAZEPAM

RTECS NUMBER : DF2370100

CHEMICAL NAME : 2H-1,4-Benzodiazepin-2-one,

1,3-dihydro-7-chloro-5-(2-fluorophenyl)-






MOLECULAR FORMULA : C15-H10-Cl-F-N2-O


WISWESSER LINE NOTATION : T67 GMV JN IHJ CG KR BF



* 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-

* 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

* CM 7116

* Descarbethoxyloflazepate

* Norfludiazepam

* Norflutoprazepam

* Ro 5-3367

* Sch 17514







TOXIC EFFECTS :


REFERENCE :

26RAAN "Benzodinzenines," Garattini, S., et al., New York, Raven Press,

1973 Volume(issue)/page/year: -,46,1973

NORGESTREL

RTECS NUMBER : JF8259000

CHEMICAL NAME : 18,19-Dinorpregn-4-en-20-yn-3-one,

13-ethyl-17-hydroxy-,

(8-alpha,9-beta,10-alpha,13-alpha, 14-beta)-






WISWESSER LINE NOTATION : L E5 B666 OV MUTJ E2 FQ F1UU1



Human


* Levonorgestrel

* l-Norgestrel

* levo-Norgestrel

* Norplant







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified


Behavioral - ataxia

REFERENCE :







TOXIC EFFECTS :



REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


Endocrine - changes in adrenal weight

Nutritional and Gross Metabolic - other changes

REFERENCE :







TOXIC EFFECTS :

Nutritional and Gross Metabolic - other changes

REFERENCE :







DOSE : 2607 ug/kg


TOXIC EFFECTS :




Endocrine - androgenic

REFERENCE :


V.1-





DOSE : 219 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 875 ug/kg


TOXIC EFFECTS :


REFERENCE :


V.1-





DOSE : 3171 ug/kg


TOXIC EFFECTS :




REFERENCE :


V.1-





DOSE : 110 ug/kg


TOXIC EFFECTS :




REFERENCE :


V.1-





DOSE : 4080 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 102 ug/kg


TOXIC EFFECTS :


REFERENCE :


V.1-



ROUTE OF EXPOSURE : Intracervical


DOSE : 12 ug/kg


TOXIC EFFECTS :


REFERENCE :


V.1-



ROUTE OF EXPOSURE : Intracervical


DOSE : 36 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 250 mg/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 2800 ug/kg


TOXIC EFFECTS :


REFERENCE :

ENDKAC Endokrinologie. (Leipzig, Ger. Dem. Rep.) V.1-80, 1928-82. For

publisher information, see EXCEDS. Volume(issue)/page/year: 76,13,1980




DOSE : 500 mg/kg


TOXIC EFFECTS :




REFERENCE :

EXCEDS Experimental and Clinical Edocrinology. (Johann Ambrosius Barth

Verlag, Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.81- 1983-





DOSE : 50 mg/kg


TOXIC EFFECTS :



REFERENCE :







DOSE : 5 mg/kg


TOXIC EFFECTS :


REFERENCE :







DOSE : 5 gm/kg


TOXIC EFFECTS :


gain)

REFERENCE :







DOSE : 200 mg/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 80 ug/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 80 mg/kg


TOXIC EFFECTS :



REFERENCE :


V.1-





DOSE : 500 ug/kg


TOXIC EFFECTS :


REFERENCE :





EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-rabbit

NUPERCAINE

RTECS NUMBER : GD3150000

CHEMICAL NAME : Cinchoninamide,

2-butoxy-N-(2-(diethylamino)ethyl)-








WISWESSER LINE NOTATION : T66 BNJ CO4 EVM2N2&2


Human


* 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide

* 2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide

* 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide

* alpha-Butyloxycinchoninic acid diethylethylenediamide

* Cinchocaine

* Dermacaine

* Dibucaine Base

* N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide

* Nupercainal

* Nupercaine

* Percamine

* 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :



1,156,1959





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

JAPMA8 Journal of the American Pharmaceutical Association, Scientific

Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see

JPMSAE. Volume(issue)/page/year: 39,4,1950





TOXIC EFFECTS :




REFERENCE :



1903/04-






TOXIC EFFECTS :


REFERENCE :



1903/04-



ROUTE OF EXPOSURE : Intraspinal



TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :

PHREA7 Physiological Reviews. (American Physiological Soc., 9650

Rockville

Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:

12,190,1932


ROUTE OF EXPOSURE : Intraspinal



TOXIC EFFECTS :


REFERENCE :


&



*** REVIEWS ***

TOXICOLOGY REVIEW

PHREA7 Physiological Reviews. (American Physiological Soc., 9650

Rockville

Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:

12,190,1932










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