YONGXING LIU, Ph.D
Research assistant professor, Department of Materials Sci & Engi
University of Missouri Sci & Tech,
Phone: 574-341-6581, liuyongx@mst.edu
EDUCATION
Ph.D Division of Biotechnological and Pharmaceutical Science, Okayama University, Japan (2004)
M.S., B.S. Dalian Institute of Light Industry (Polytechnic University), China (2001; 1998)
WORK EXPERIENCE
Research Assistant Professor, University of Missouri Science and Technology (11/2011-present)
Visiting Research Assistant Professor, University of Notre Dame (7/2010-10/2011)
Post-doctoral fellow 1, University of Connecticut Health Center (2008 – 6/2010)
Post-doctoral trainee, University of Tennessee Health Science Center (2005-2007)
TEACHING EXPERIENCE
Manager of the Cell and Tissue Culture Laboratory, University of Notre Dame (7/2010-10/2011)
Teaching laboratory classes for graduates, UTHSC (2007)
Supervising dental students for summer projects, UTHSC (2007)
Supervising dental students for summer projects, UTHSC (2006)
AWARDS
Aircast Award for Basic Science Repair of osteochondral defect with biphasic cartilage tricalcium phosphate
implantation in a porcine allograft model. A Fosnaugh, J Huang, H Cho, Y Liu, Y Yang, KA Hasty, FM Azar.
The American Orthopaedic Society for Sports Medicine, Orlando, FL, 2008.
Ribbon Award: Best Paper Nomination in Nanoscale Materials Science in Biology and Medicine 2005. S
Hayagawa [was my supervisor], Y Liu et al., Nanoscale Materials Science in Biology and Medicine, edited
by Cato T. Laurencin and Edward A. Botchwey (Mater. Res. Soc. Symp. Proc. 845, Warrendale, PA, 2005).
Award of the Outstanding Papers Published in the Journal of the Ceramic Society of Japan in 2004. Y
Liu et al., In vitro bioactive nanocrystalline titania layers grown at glass-coating/titanium interface. J Ceram
Soc Japan. 2004.
PATENTS
Y. Yang, Y Liu. Method for increasing the strength and controlling composition and architecture of ceramic
articles. Non-Provisional Patent Application No. US12/074,434, Filed on March 16, 2008.
Y. Yang, Y Liu. Method for making ceramic articles, including ceramic scaffolds for bone repair. Provisional
Patent Application No. US61/131,810, Filed on June 12, 2008. Converted to PCT/US 09/03501, filed on June
10, 2009. (Claims allowed, 2011).
BOOK CHAPTERS AND REVIEW PAPERS
AJ Steward, Y Liu, DR Wagner. Engineering cell attachments to scaffolds in cartilage tissue
engineering (review paper). JOM, 63, 72, 2011.
Y Liu, SW Park, HS Kim, KM Lee, JT Koh, SK Nishimoto, JD Bumgardner, W Haggard, Y Yang.
Engineered Titanium Surface Promoting Osseointegration. In: Biomaterials and Biomedical
Engineering (ISBN0878494804), Ed. W. Ahmed, N. Ali and A. Öchsner.Trans Tech Pub Ltd. 2008.
Y Yang, Y Liu, S Park, H Kim, K Lee and J Koh, Nanoscale Bioactive Surfaces and Endosseous
Implantology in Nanoscience and Its Applications in Biomedicine (ISBN9783540496601). Editor D
Shi, Springer-Verlag and Tsinghua University Press. 2009.
JL Ong, Y Yang, S Oh, M Appleford, W Chen, Y Liu, KH Kim, S Park, J Bumgardner, W Haggard,
CM Agrawal, DL Carnes and N Oh. Sputtered hydroxyapatite coatings. In: Thin calcium phosphate
coating for medical implants (ISBN: 97803877771847), Ed. B Leon, P Li, J Jansen. Springer. 2009.
PEER-REVIEWED PAPERS (INCLUDING MANUSCRIPTS OF THE MOST RECENT WORK)
Y Liu, AJ Goldberg, LT Kuhn. Robust and complete bone regeneration by mesenchymal stem celllike cells derived from human embryonic stem cells using growth factor cocktails. Manuscript is
under internal review. 2011.
Y Liu, AJ Goldberg, TI Zarembinski, SK Atzet, LT Kuhn. Modified hyaluronan hydrogels for the
feeder-free culture of human induced pluripotent stem cells. Manuscript is under internal review.
2011.
Y Liu, DR Wagner. FGF-2 and dexamethasone pretreatment dose not significantly affect the
chondrogenic ability of human adipose-derived stem cells. Submitted to Cell Biol Intl. 2011.
Y Liu, AJ Goldberg, J Dennis, G Gronowicz, LT Kuhn. One-step derivation of mesenchymal stem
cell (MSC)-like cells from human pluripotent stem cells on a nano fibrillar collagen coating.
Submitted to PLoS One, 2011.
LT Kuhn, Y Liu, M Advincula, YH Wang, P Maye, AJ Goldberg. Fluorescent quantification of
osteogenesis of lineage specific GFP reporter preosteoblasts on biomimetic matrix. Tissue Eng Part
C, 16, 1357, 2010.
AJ Goldberg, Y Liu ,M Advincula, G Gronowicz, L Kuhn. Biomimetic matrix promotes attachment
and proliferation of MC3T3 and primary calvarial osteoblasts. J Biomater Sci, Polym edt, 21, 1371,
2010.
Y Liu, J Kim, D Young, S Kim, S Nishimoto, Y Yang. Novel template-casting technique for
fabricating ß-tricalcium phosphate scaffolds with high interconnecitivity and mechanical strength and
in vitro cell responses. J Biomed Mater Res Part A. 92A, 997, 2010.
S Kim, Y Liu, MW Gaber, JD Bumgardner, WO Haggard, Y Yang. Development of chitosan-ellagic
acid films as a local drug delivery system to induce apoptotic death of human melanoma cells. J
Biomed Mater Res Part B. 90, 145, 2009.
Y Liu, W Chen, Y Yang, JL Ong, K Tsuru, S Hayakawa, A Osaka. Novel fabrication of nano-rod
array structures on titanium and in vitro cell responses. J Mater Sci Mater Med. 19, 2735, 2008
Y Yang, S Park, Y Liu, K Lee, H Kim, J Koh, X Meng, K Kim, H Ji, X Wang, JL Ong.
Development of sputtered nanoscale titanium oxide coating on osseointegrated implant devices and
their biological evaluation. Vacuum. 83, 569, 2008.
S Nishimoto, M Nishimoto, S Park, K Lee, H Kim, J Koh, JL Ong, Y Liu, Y Yang. The effect of
titanium surface roughening on protein absorption, cell attachment, and cell spreading. J Oral
Maxillofac Implants, 23, 675, 2008.
C Wang,Y Liu,Y Xia,T Ma, PW Wang.Characteristics of ITOfilms fabricated on glass substrates by
high intensity pulsed ion beam deposition. J Non-cryst Solids,353,2244,2007.
W Chen, A Ong, N Oh, Y Liu, HS Courtney, M Appleford, JL Ong. Anti-bacterial and osteogenic
properties of silver- containing hydroxyapatite coatings produced using a sol-gel process. J Biomed
Mater Res Part A. 82, 899, 2007.
W Chen, Y Liu, HS Courtney, M Bettenga, CM Agrawal, JD Bumgardner, JL Ong. In vitro antibacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite
coating. Biomaterials, 27, 5512, 2006.
W Chen, Y Liu, Y Yang, Q Ouyang, JL Ong, In vitro bacterial adhesion properties of radio
frequency magnetron sputtered HA coating. J Practical Medicine, 22, 2825, 2006.
Y Yang, N Oh, Y Liu, W Chen, S Oh, M Appleford, S Kim, K Kim, S Park, J Bumgardner, W
Haggard, JL Ong. Enhancing osseointegration using surface modified titanium implants. J Miner
Metals Mater Soc, 5,71, 2006
C Wang, Y Liu, T Ma,Y Xia.Technique of depositing ITO films on glass substrate by high intensity
pulsed ion beam method. J Chinese Ceram Soc, 29, 249, 2001.
W Chen, Y Liu, HS Courtney, M Bettenga, CM Agrawal, JD Bumgardner, JL Ong. In vitro antibacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite
coating. Biomaterials, 27, 5512, 2006.
Y Liu, K Tsuru,S Hayakawa,A Osaka.Topotaxial nucleation and growth of sub-m scale TiO2 rod
arrays on titanium via sodium tetraborate glass coatings. J Ceram Soc Japan,112,567,2004.
Y Liu, K Tsuru, S Hayakawa, A Osaka. In vitro bioactive nano-crystalline TiO2 layers grown at
glass-coating/titanium interface. J Ceram Soc Japan, 112, 453, 2004.
Y Liu, K Tsuru, S Hayakawa, A Osaka. titanate nanorod arrays grown on titanium substrates and
their in vitro bioactivity. J Ceram Soc Japan, 112, 634, 2004.
Y Liu, H Shang, L Yu, C Wang, Y Tao. Morphology and properties of rare-earth elements doped
porous titanium oxide films coated on glass surface by sol-gel method. Mater Rev, 16, 64, 2001.
PROCEEDINGS AND PRESENTATIONS
RJ Kane, Y Liu, D Wagner, RK Roeder. Hydroxyapatite reinforced collagen scaffolds with
improved mechanical properties and in vitro osteogenicity for adipose-derived stromal cells. The 9th
World Biomaterials Congress (WBC) Chengdu, China, June 1-5, 2012 (accepted).
Y Liu, AJ Goldberg, LT Kuhn. Modified hyaluronic acid hydrogel for maintaining human induced
pluripotent stem cells. SFB 2011 Annual Meeting & Exposition, Orlando, FL, April 13-16, 2011.
LT Kuhn, Y Liu, NL Boyd, JE Dennis, H Aguila, A Lichtler, AJ Goldberg. Substantial mouse
calvarial bone defect healing by human embryonic stem cells, 2011 Annual Meeting of the
Orthopaedic Research Society (ORS), Long Beach, CA Jan 13-16, 2011.
Y Liu, DR Wagner. Heterogeneity in the chondrogenic culture of murine adipose tissue-derived stem
cells. Tissue Engineering & Regenerative Medicine International Society North America (TERMISNA) 2010 Annual Conference, Orlando, FL, Dec 5-8, 2010.
T Zarembinski, Y Liu, R Wesselschmidt, L Kuhn, M Wight, A Mccollough, T Tandeski, S Atzet. A
novel feeder-free pluripotent stem cell culture substrate that supports pluripotent stem cell growth
and proliferation. TERMIS-NA 2010 Annual Conference, Orlando, FL, Dec 5-8, 2010.
Y Liu, NL Boyd, JE Dennis, AC Lichtler, AJ Goldberg, LT Kuhn. Robust Calvarial Bone Defect
Repair by hESCs. TERMIS-NA 2010 Annual Conference, Orlando, FL, Dec 5-8, 2010. (accepted).
Y Liu, AJ Goldberg, JT Elliott, AL Plant, LT Kuhn. Osteogenesis by hESCs after culture on fibrillar
type I collagen coatings. SBE's Second International Conference on Stem Cell Engineering,
Boston, MA, May 2-5, 2010.
Y Liu, AJ Goldberg, LT Kuhn. Variance of EXTRACEL hydrogel compositions and the osteogenic
effects on GFP-reporter preosteoblasts. Society for Biomaterials 2010 Annual Meeting and
Exposition, Seattle, April 21-24, 2010.
K Johnson, Y Liu, R Wesselschmidt, LT Kuhn, M Wight, A McCollough, TI Zarembinski, SK Atzet.
A novel feeder-free pluripotent stem cell culture substrate that supports mouse embryonic and human
induced pluripotent stem cell growth and proliferation. Society for Biomolecule Science 16th Annual
Conference & Exhibition Phoenix, AZ, April 11-15, 2010.
Y Liu, AJ Goldberg, JT Elliott, AL Plant, LT Kuhn. Osteogenic differentiation of hESCs after
culture on fibrillar type I collagen coatings. 36th Annual Northeast Bioengineering Conference, New
York, March 26-28, 2010.
Y Liu, AJ Goldberg, LT Kuhn. Direct differentiation of singly dissociated human embryonic stem
cells in the presence of rock inhibitor Y27632. 2009 Junior Investigator Symposium of New England
Stem Cell Consortium. Oct 10, Shrewsbury, MA, 2009.
J Huang, A Fosnaugh, H Cho, Y Liu, Y Yang, KA Hasty, FM Azar. Beta-tricalcium phosphate as an
osteoconductive material to preserve subchondral plate for osteochondral repair. ORS 55th Annual
Meeting, 2009.
Y Liu, LT Kuhn, M Advincula, YH Wang, P Maye, AJ Goldberg. Fluorescent quantification of
osteogenesis of GFP-transgenic mouse calvarial osteoblasts on biomimetic coatings. Society for
Biomaterials 2009 Annual Meeting and Exposition, San Antonio, TX, April 22, 2009.
Y Liu, JH Kim, D Young, SK Nishimoto, R Heck, Y Yang. Biomimetic macroporous scaffolds with
high mechanical strength and biological evaluation. IADR/AADR/CADR 87th General Session and
Exhibition, April 1-4, 2009.
S Zhan, B Lawton, M Duffin, G Gong, D Ferrari, Y Liu, R Xu, D Rowe, D Goldhamer, R Kosher, A
Lichtler. Lentivirus vector mediated delivery of cell type specific fluorescent protein markers to
human embryonic stem cells. The 1st annual connecticut stem cell technology symposium:molecular
advances in the discovery and translation of stem cell research. Farminton, CT, Sept. 17, 2008.
J Huang, A Fosnaugh, H Cho, Y Liu, et al., Repair of osteochondral defect with biphasic cartilagetriclacium phosphate implantation in a porcine allograft model. The American Orthopaedic Society
for Sports Medicine, Orlando, FL 2008.
S Weiskope, Y Liu, et al.,Chondroitin sulphate grafting on titanium and cell Attachment.
IADR/AADR/CADR 85th General Session and Exhi, March 21-4, 2007, New Orleans, LA.
S Kim, Y Liu, et al.,Chitosan-ellagic acid composite films induce apoptotic death of human
melanoma cells. the SFB 2007 Annual Meeting& Expo:Biomaterials, 2007,Chicago, IL.
Y Liu, et al.,Macroporous tricalcium phosphate scaffolds derived from freeze-drying.The SFB 2007
Annual Meeting and Exposition: Biomaterials, April 18-21,2007,Chicago, IL.
Y Liu, et al., Fabrication of TiO2 rod array and evaluation for cell attachment. The
ADEA/AADR/CADR Meeting & Exhibition, March 8-11, 2006, Orlando, FL.
W Chen, Y Liu, et al., Effect of calcium phosphate coating crystallinity on pre-osteoblast responses.
The ADEA/AADR /CADR Meeting, March 8, 2006, Orlando, FL.
M Moore,M Appleford,Y Liu,et al.,Osteoblast responses to Ti-Ta-Nb alloy and its nanosize crystal
coatings.The ADEA/AADR/CADR Meeting&Exhib,March,2006, Orlando, FL.
Y Liu, et al., Preparation of titania nano-rod array on titanium substrates by microflux
method. Ceramic Trans,159 (Ceramic Nanomaterials and Nanotechnology III), 193, 2005.