1. Personal details Name Date of birth Place of birth Nationality Address Tel no. Fax no E-mail 2. Medical Experience : Aristotle Bamias : 25 April 1962 : Athens : Greek : 57A Taygetou st, Vrilissia, 152 35 Athens : 0030 2103381546, 0030 6944861060 : 0030 2103381511 : abamias@med.uoa.gr Education and Postgraduate Medical September 1980-December 1986 Undergraduate Medical Education, Medical School, University of Athens January 1987- December 1988: MD Thesis, Medical School, University of Athens January 1989-January 1993 PhD student Dept of Clinical Oncology, Hammersmith Hospital, University of London 26 May 1987-16 August 1987 SHO in General Medicine Evanghelismos Hospital, Athens 17 August 1987-20 June 1988 SHO in General Medicine 3rd Internal Medicine Dept, Agii Anargyri Hospital, Athens 1 February 1993-31 July 1993 SHO in General Medicine Northern General Hospital, Sheffield 1 August 1993-31 January 1994 SHO in General Medicine/Oncology Royal Marsden Hospital, Sutton 1 February 1994-31 August 1994 Clinical Research Fellow in GI and Lymphoma Unit Royal Marsden Hospital, Sutton 1 September 1994-28 February 1995 SHO in General Medicine/Neurology Oldhurch Hospital, London 1 NHS and University posts held 1 March 1995-31 November 1995 Lecturer /Honorary Registrar in Medical Oncology St. Bartholomews Hospital, London 27 March 1997- 7 October 2002 Consultant in Medical Oncology University Hospital, Ioannina, Greece 8 October 2002-27 August 2007 Lecturer in Therapeutics, Medical School, University of Athens 28 August 2007-2 September 2012 Assistant Professor in Therapeutics, Medical School, University of Athens 25 August 2011: Permanent Faculty Member, Medical School, University of Athens Present post (since 3 September 2012) Associate Professor in Therapeutics, Medical School, University of Athens Affiliation: Oncology/Haematology Unit, ALEXANDRA Hospital, 80 Vasilissis Sofias Ave., 115 28 Athens, Greece Tel no. 0030 210 3381546 Fax no. 0030 210 3381511 3. Qualifications, Certificates 25 January 1987 9 May 1990 2 July 1991 15 June 1994 27 November 1995 7 November 1998 Ptychio Iatrikes (MB,BS in Medicine), University of Athens Doctorate in Medicine (MD), University of Athens. Certificate in Immunology, King’s College, University of London. Ph.D., University of London. Title: The development of a prodrug activation system for cancer therapy M.R.C.P. (U.K.) ΕSMO Certificate 4. Accreditation of specialties 7 March 1996: Internal Medicine, Ministry of Health, Greece 24 May 2000: Medical Oncology, Ministry of Health, Greece Hellenic Medical Association no. 052965 GMC Registration no: 3422049 (1989-1995; not paid for renewal after my return to Greece-now in the process of restoration) 2 5. Member of International Scientific Bodies-Societies 1996 Full member of the European School of Medical Oncology (ESMO) 2001 Full member of the American Society of Clinical Oncology (ASCO) 2006 Member of the European Society of Gynaecological Oncology (ESGO) 6. Scholarships, Prizes 1980-1986 1989-1991 1992 1991 2004 2005 2009 Scholarship by the Athenean Club Scholarship by the Greek Ministry of Economy Scholarship by the “Alexandros Onassis” Foundation The Galen Prize by the Hellenic Medical Society, London First Prize at the 12th Greek National Congress of Medical Oncology Second Prize at the 14th Greek National Congress of Medical Oncology Prize for the best Poster: «Changes in lymphocytic populations and autoantibodies resulting from sunitinib treatment of metastatic renal cell carcinoma (mRCC). Karadimou A, Gavalas N, Sereti E, Gyftaki R, Lainakis G, Dimopoulos MA, Bamias A. 1st Congrress Mediteranean Multidisciplinary Oncology Forum, Athens 10-13 September 2009 7. Teaching and Educational activity-duties 6.1. St Bartholomew’s Hospital (1995) Undergraduate Education 5th year of Medical School, University of London (Physical Examination) 6.2. Ioannina University Hospital (1997-2002) Undergraduate Education 3rd year of Medical School, University of Ioannina (Physical Examination) 4th year of Medical School, University of Ioannina (Physical Examination) 6th year of Medical School, University of Ioannina (Internal Medicine) Postgraduate Education 2 Postgraduate Courses 6.3. Medical School, University of Athens (2002-cont) Undergraduate Education Faculty member in charge of the subject “ONCOLOGY I” 5th year of Medical School (teaching subject: Therapeutics) 6th year of Medical School (teaching subject: Internal Medicine) Teaching of Clinical Pharmacology (2006-2010) Teaching of Gynaecological Oncology (2011-cont) Teaching of the 3rd Summer School of Oncology, 5th year of all Greek Medical Schools (2009) Postgraduate Education 3 Co-ordinator of the Genitourinary Oncology Courses of the Hellenic Society of Medical Oncology Teaching at 4 Postgraduate Courses of the Medical School, University of Athens Teaching at Postgraduate Courses of Residents in Urology Participation as a lecturer in numerous Postgraduate courses Teaching Books (participating author) Clinical Therapeutics (Medical School, University of Athens) Clinical Oncology (Medical Schools of all Greek Universities) Internal Medicine (Medical School, University of Athens) Urogenital and Gynaecological Oncology (Hellenic Society of Medical Oncology-3 books) Supervisor of Medical Theses, Athens University: 8 8. Clinical experience-duties Major focus: Treatment of genitourinary and gynaecological malignancies Details of clinical experience and duties UK (SHO, Clinical Fellow, lecturer in Medical Oncology) (1993-1995) Internal Medicine (Northern General Hospital, Oldchurch Hospital) Management of patients in the Wards On call rotation Outpatients Clinics Medical Oncology (Royal Marsden Hospital, St Bartholomew’s Hospital) ● treatment of GI, GU, lung and ovarian cancer and Lymphomas: clinical duties in the wards, outpatient clinics and Day Units ● Multidisciplinary meetings for GYN cancers ● on call rotation University Hospital of Ioannina (Consultant in Medical Oncology) (1997-2002) ● management of patients with solid tumors (focus on GI and GU malignancies): clinical duties in the wards, outpatient clinics and Day Unit ● Introduction of the continuous infusion of 5-FU in GI malignancies ● training of residents in medical oncology ● on call rotation (Medical Oncology Dept and A+E). Present post Dept Of Clinical Therapeutics, Alexandra Hospital, Athens (Lecturer and Assistant Professor, Medical school, University of Athens) (2002-cont) 4 Management of Oncology patients (Consultant) in the Wards of the Dept of Clinical Therapeutics and Outpatients Clinic of the Oncology Unit on a daily basis The Unit treats an average of 50 cancer patients/day including solid tumors and haematological malignancies. The medical personnel includes 6 Consultants-Faculty members of Athens University and 5 Medical Oncology Registrars. The Dept of Clinical Therapeutics, where the Unit belongs has 80 General Medicine beds and the medical personnel covers most of the Medical specialties. Patients of the Haematology/Oncology Unit who require admission, are admitted to the Dept of Clinical Therapeutics. The Hospital also has a ITU, ICU and a CVA Unit. It also hosts the First Obsterics and Gynaecology Dept of the University of Athens, which includes a very active Gynaecological Oncology Unit, with 3 Gynaecology Oncology Consultants-members of the university Faculty. The Gynaecology Oncology Unit is responsible for the surgical management, while chemotherapy is administered and managed by the Haematology/Oncology Unit. The Hospital is a referral center for gynaecological and genitourinary cancer as well as peripheral stem cell transplantation. Outpatients Medical Oncology Clinic in Private Suite (twice a week) Training of Medical Oncology Registrars On call duty (Consultant) for General Medicine Rotation as Co-ordinator of the A+E Dept (Medical) Member of the Gynaecological Oncology multi-disciplinary team (Alexandra Hospital) Member of the Genito-Urinary Cancer multi-disciplinary team (Alexandra-Sismanoglion Hospitals) 9. Research and Laboratory activities Major fields of research: Genitourinary and Gynaecological Cancer, Translational Research, Tumor Immunology. 9.1. Detailed description of Research subjects Doctorate (University of Athens). ● Study of immunohistochemical expression of two monocloncal antibodies in normal mucosa, polyps and cancer of the colon (publication no. 2). Ph.D. (University of London) (publication nos 3,4,6,7) ● The experiments were performed at the Imperial Cancer Research Fund Laboratory and the Pathology Dept, Hammersmith Hospital, London. The project included: basic research: production of a monoclonal antibody conjugate, study in cell culture, production of novel monoclonal and polyclonal antibodies, experiments to animal models clinical research: pharmacokinetics of monoclonal antibodies, after instillation in the bladder of patients with bladder cancer. 5 result: the development of a selective cyanide generating system at tumor microenvironment Hammersmith Hospital, London, UK Regional administration of monoclonal antibodies for caner diagnosis and treatment (publication nos 1,5). Royal Marsden Hospital, Sutton, Surrey, UK and University Hospital, Ioannina, Greece ● use of continuous 5-FU infusion for the treatment of GI malignancies, pharmacokinetic studies (publication nos 8,9,36). ● translational research (publication nos 21,98). ● clinical research: multicenter Greek studies (publication nos 14,17,19,20,24,25,29,34,35) Research at current post ● design and conduct of multicenter clinical studies (national and multinational) (role: study PI, member of Steering Committee or center PI) of GU and GYN malignancies (publication nos 38,39,48,50,51,56,58,67,70,72,75,78,79,82,84,91,92,94,99,102,119,130,134, 140,143,164). ● development, maintenance, update and analysis of databases of characteristics, treatment and outcome of patients with GU and GYN cancers of our Unit. The work on the databases is sponsored by my involvement in industry-sponsored clinical studies. The statistical team consists, apart from myself, of Mrs Kakoyiannis (Data Manager), Dr Tzannis (biostatistician) and Dr C. Bamia (Assistant Professor in Epidemiology, University of Athens) and involves international collaboration. (publication nos 35,39,48,58,67,75,78,82,92,94,99,102,130,140,143,150,152,154,158). ● side effects of anti-tumor treatment (publication nos 42,45,52,71,112,118,122,123,137,149,153,155,156,161). My studies on osteonecrosis of the jaw secondary to bisphosphonate therapy have been used in the development of international guidelines for this manifestation ● Faculty Member in charge of the Research Laboratory of the Dept of Clinical Therapeutics The Laboratory has been established since 2004. The main research activity is focused on the predictive and prognostic role of elements of the immune response (publication nos 61,85,95,124,128,144,148) in Genitourinary and Ovarian cancer. The other main interest is angiogenesis (publication nos 22,27,41,47,53,55,64,66,77,81,87,88,103,113,129) and its role in immune response and resistance to systemic treatment. The personnel consist of 4 biologists and several postgraduate students. The costs are covered by my involvement in industry-sponsored clinical studies as well as by programs sponsored by the Greek state and the EU. There is tissue bank, which is dedicated to the storage of biological material of patients with renal, bladder and ovarian cancer, who are managed in our Unit. The Laboratory is equipped with a flow cytometer, tissue culture, ELISA, PCR and facilities for Western blot. There is also equipment for cryopreservation used for stem cell transplantation. 6 9.2. Member of Co-operative Groups 1. Hellenic Co-operative Oncology Group (HECOG) Co-ordinator of the Quality of Life Working Group (1996-2004) (publication no 19) Co-ordinator of the Genitourinary Working Group (2004-2012) The Working Group has conducted a considerable number of clinical studies in genitourinary cancer, including two randomized, phase III trials in urothelial cancer (publication nos 24,28,29,39,58,91,119,120,134). Recently there has been a focus in translational research studying prognostic and predictive factors in patients treated with chemotherapy (publication nos 103,113) including international collaboration. Member of the Scientific Committee (1996-2012) 2. European Network of Gynaecologic Oncology Trials (ENGOT) Groups (publication nos 133,158,159) Representative of Greece-HECOG (2010-2013) This is the most recent field of international collaboration of the Hellenic Cooperative Oncology Group aiming to participate in multinational collaborative studies. HECOG has already participated in two studies, which I am a member of the Steering Committees. 3. Hellenic Genito-Urinary Cancer Group (HGUCG) Founding Member and Chair of the the Directing Committee of HGUCG, which includes Greek Medical Oncologists, Urologists and Scientists with an interest in research on GU Cancer. The aim of this group is to provide a platform for the collaboration of these specialists, apply high standards of care and promote research in GU Cancer. 9.3. Sponsored research 1. Hellenic Society of Medical Oncology 2003-2004 5,500€ Study of the expression of COX-2 in urothelial carcinoma 2004-2005 5,870 € Study of lymphocytic populations and cytokines in ascites from ovarian cancer 2012-2013 6,000 € Study of angiogenic factors in the ascetic fluid from patients with advanced ovarian cancer 2. University of Athens (2006-2009): 10000€ Study of the prognostic significance of molecular and angiogenic factors in ovarian canrcinoma 3. EEC and Ministry of Education of Greece (2004-2007): 50,000€ In vitro and in vivo study of the immune anti-tumor response in patients with ovarian cancer. Prognostic and predictive value 7 4. Ministry of Development of Greece: 66,000€ (Greek-USA collaboration, Co-Investigator) Combinational immunotherapy for the best anticancer action of NK cells. A study in vitro and in experimental models. 5. Ministry of Health of Greece (2005-2006): 14,650€ (Co-Investigator) In vitro augmentation of cytotoxic ability of human ΝΚ cells with cytokines and their utility in in vivo models of cell immunotherapy of cancer. 6. FP7-REGPOT-2011 programe (Code: REGPOT-CT-2011-284460 INsPiRE) 2011-2014: 3.722.000€ (Co-Investigator) Integrating the emerging research potential of the University of Athens cancer Research group in the European research area 7. Research funding by several pharmaceutical companies for the research activities of the Laboratory of the Dept of Clinical Therapeutics. 9.4. Research collaboration 9.4.1. Greek Centers 1. Α’ Dept of Obstetrics and Gynaecology, University of Athens (see list of publications) 2. Β’ Urology Dept, University of Athens (see list of publications) 3. Pathology Dept, University of Athens (publication nos 87,103,113) 4. Laboratory of Epidemiology, University of Athens (publication nos 52,71,112,150,152,154,158) 5. Immunology Laboratory, University of Athens (publication nos 61,85,95,116,148) 6. Institute of Biological Research and Biotechnology, Athens, Greece (publication no 163) 9.4.2. International collaboration 1. Department of Medical Oncology, Yale University, School of Medicine (Assistant Professor A. Psyrri) (publication nos 53,55,66,77) 2. French collaborative national database (Professor M. Roupret, publication no 150) 3. Harvard Medical School (Professor J. Rosenberg, Professor J. Bellmunt) 4. Georges Pompidou Hospital, Paris, France (Professor S. Oudard, publication no 182) 5. University of Pavia, Italy (Professor C. Porta) 6. Mount Sinai, School of Medicine (Dr M. Galsky, Dr S. Grossman) (publication no 176,179-181) 7. Invited Professor by the Oncology Dept, Hopital Universitaire de Geneve (Prof. P-Y. Dietrich) for Urogenital Cancer (March-August 2012) 9.5. Participation in international multicenter trials 9.5.1. Member of Steering Committee AURELIA (platinum-resistant ovarian cancer, oral presentation at ASCO 2012) TRINOVA-3 (1st line ovarian cancer, accruing) 8 PRINCIPAL (pazopanib in metastatic renal cell carcinoma, still accruing) 9.5.2. Institution PI: 7 (publication no. 164) 9.5.3. Investigator: 10 (publication no. 168) 10. International Faculty Member, Consensus Groups 1. Member of the Faculty of Urogenital Cancer of the Educational Committee of the European School of Medical Oncology (ESMO) (20122014). 2. Guidelines for the management of prostate cancer by international Group of Experts (publication 110) 3. Member of the ESMO Guidelines Working Group for testicular cancer (publication nos 138,139). 4. Member of numerous international Advisory Boards 11. Editorial Board of international journals 1. 2. 3. 4. 5. Forum of Clinical Oncology (2010-cont’d) Open Access Urology (2009-cont’d) Annals of Urology (up to 2010) CML Kidney Cancer (up to 2010) Experimental Hematology & Oncology (2012-cont’d) 12. Reviewer 1. 2. 3. 4. 5. 6. 7. 8. 9. Oncology-Basel Annals of Oncology European Urology Cancer Chemotherapy Pharmacology Clinical Cancer Research World Journal of Urology Expert Review of Anticancer Therapy Nature Reviews International Journal of Urology etc 13. Editor 1. RCC CASE STUDIES: Guest Editor of the first edition 2. Achieving Optimal Outcomes in Patients with Cardiovascular Complications. Therapy Management Series. Eds: M. Schmidinger, J. BurgerKlein, A. Bamias. 14. Invited speaker to 33 international congresses (selected presentations below): Special Symposium: Management of renal cancer. Introduction. 31rst ESMO Congress 2006 9 Poster Discussion: “Genitourinary cancer”. Discussant 31st ESMO Congress, 2006. Therapeutic options for stage-I seminoma. Surveillance. 3rd World Congress on Controversies in Urology, 2010 Renal tumors: case discussion debates. 3rd World Congress on Controversies in Urology 2010 Neoadjuvant or adjuvant chemotherapy when the renal function is impaired: for some patients, for all patients, for no patients? 3rd World Congress on Controversies in Urology. 2010 Round Table. Combination therapy with targeted agents is the future. EAU Congress, Barcelona 2010 Treating through co-morbidities 2nd Annual Conference of Renal Cancer Experts (CORE). Hamburg April 2011. Interactive Satellite Symposium: “Navigating therapeutic opportunities and investigational approaches for patients with Genitourinary Malignancies”. ESMO Congress,Stockholm 2011 Oral abstract presentations in selected congresses: ASCO: 2 (GU session) ESMO: 2 (GI and GU session) Chair in Round Tables/Sessions in international Congresses/Meetings: 7 15. Social Activities Participation in awareness broadcasts, articles and interviews on issues of cancer diagnosis and management in tv and paper and electronic press 16. Publications (excluding Greek publications) 16.1. Analysis of publications Abstracts in international Congresses: 92 Chapters in English books: 11 Publications in peer reviewed journals: 184 Publication subject Application of monoclonal antibodies in oncology: 7 GI cancer: 19 GU cancer: 59 GYN cancer: 55 Other malignancies: 28 10 Complications of anti-cancer therapy: 15 Cardiology: 1 1st author: 55 (32%) 2nd author: 19 (10%) Last author: 36 (20%) Origin of work Greece: 157 International: 27 Content Guidelines: 5 Basic research: 6 Clinical studies: 97 Translational research: 31 Reviews: 21 Case reports: 13 Editorials: 5 Letters to the Editor: 4 Publications accompanied by an Editorial: 3 Publication impact factor (June 2012): 632,293 (mean: 3,78) Citations (February 2013) (scopus): 4072 H-index (February 2013): 33 16.2. Publications in peer-reviewed journals (citations updated at June 2012) 1. Kalofonos HP, Cosmas C, Pawlikowska TRB, Bamias A, Snook D, Dhokia B, Sivolapenko GB, Courtenay-Luck NS, Epenetos AA. Immunolocalisation of testicular tumors using radiolabelled monoclonal antibody to placental alkaline phosphatase. J Nucl Med Allied Sci, 34: 294-298, 1990. (citations: 4) 2. Anagnostaki E, Skarlos D, Tamvakis N, Psaropoulou P, Blana E, Bamias A, Legaki S, Aravantinos G, Deliveliotis C, Dimopoulos K. Immunohistochemical and immunocytochemical study of bladder carcinomas using the epithelium-specific, tumour -associated monoclonal antibodies HMFG1 and AUA1. Br J Cancer, 62(suppl x): 52-56, 1990. (citations: 11) 11 3. Bamias A, Keane P, Krausz T, Williams G, Epenetos AA. Intravesical administration of radiolabelled antitumor monoclonal antibody in bladder carcinoma. Cancer Res, 51: 724-728, 1991. (citations: 32) 4. Rowlinson-Busza G, Bamias A, Krausz T, Epenetos AA. Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumour injection. Cancer Res, 51: 3251-3256, 1991. (citations: 21) 5. Hird V, Vorhoeyen M, Badley RA, Price D, Snook D, Kosmas C, Gooden C, Bamias A, Meares C, Lavender JP, Epenetos AA. Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. Br J Cancer, 64: 911-914, 1991. (citations: 36) 6. Bamias A, Epenetos AA. Two step strategies for the diagnosis and treatment of cancer with bioconjugates. Antibody, Immunoconjugates and Radiopharmaceuticals, 5(4): 385-395, 1992. (citations: 17). 7. Bamias A, Bowles MJ, Krausz T, Williams G, Epenetos AA. Intravesical administration of indium-111-labelled HMFG2 monoclonal antibody in superficial bladder carcinomas. Int J Cancer 54: 899-903, 1993 (citations: 13) 8. Bamias A, Cunningham D, Nicolson V. Adjuvant chemotherapy for oesophagogastric cancer with Epirubicin, Cisplatin & infusional 5Fluorouracil (ECF): A Royal Marsden pilot study. Br J Cancer, 71(3): 583587, 1995. (citations: 14) 9. Bamias A, Hill M, Cunningham D, Norman A, Ahmed F, Webb A, Watson M, Hill A, Nicolson M, O’Brien M.E, Evans C, Nicolson V. Epirubicin, Cisplatin and protracted venous infusional 5-Fluorouracil (ECF) for gastroesophageal adenocarcinoma: Response, toxicity, quality of life, and survival. Cancer, 77(10): 1978-1985, 1996. (citations: 71) 10.Gossios K, Tsianos E, Nicolson V, Bamias A, Cunningham D, Husband J. CT evaluation of the resectability of gastric cancer post chemotherapy. Abdominal Imaging, 21:293-298, 1996. (citations: 5) 11.Ngi VWK, Husband GES, Nicolson VMC, Minty I, Bamias A. CT evaluation of treatment response in advanced gastric cancer. Clinical Rad, 51: 214220, 1996. (citations: 8) 12.Bamias A, Pavlidis N. The management of pleural mesothelioma. SouthAmerican Journal of Cancer 2(1): 97-101, 1997. 13.Bamias A, Pavlidis N. Systemic chemotherapy in gastric cancer: Where do we stand today? Oncologist, 3: 171-177, 1998. (citations: 9). 14.Dimopoulos M, Bakoyiannis C, Georgoulias V, Moulopoulos L, Deliveliotis C, Karayannis A, Varkarakis I, Aravantinos G, Zervas A, Pantazopoulos D, 12 Fountzilas G, Bamias A, Kyriakakis Z, Anagnostopoulos A, Giannopoulos A, Kosmidis P. Docetaxel and Cisplatin combination chemotherapy in advanced carcinoma of the urothelium: a multicenter phase II study of the Hellenic Cooperative Oncology Group. Ann Oncol, 10 (11): 1385-1388, 1999. (citations: 48) 15.Katsimbri P, Bamias A, Peponis I, Froudarakis M, Konstantopoulos S, Pavlidis N. Endobronchial metastases secondary to solid tumours: Report of eight cases and review of the literature. Lung Ca, 28(2): 163-170, 2000. (citations:49) 16.Katsimbri P, Bamias A, Pavlidis N. Prevention of chemotherapy- induced alopecia using an effective scalp cooling system. Eur J Cancer, 36: 766771, 2000. (citations: 37) 17.Christodoulou C, Bafaloukos D, Kosmidis P, Samantas E, Bamias A, Papakostas P, Karabelis A, Bacoyiannis C, Skarlos DV. Phase II study of Temozolamide in heavily pretreated patients with brain metastases from solid tumors. Ann Oncol, 12(2): 249-254, 2001. (citations: 106) 18.Bamias A, Baltayiannis G, Kamina S, Fatouros M, Lymperopoulos E, Agnanti N, Tsianos E, Pavlidis N. Rectal metastases from lobular carcinoma of the breast: report of a case and literature review. Ann Oncol, 12(5): 715-718, 2001. (citations: 23) 19.A. Bamias, G. Aravantinos, C. Kalofonos, N. Timotheadou, V. Siafaka, I. Vlahou, D. Janinis, D. Pectasides, N. Pavlidis, G. Fountzilas. Prevention of anemia in patients with solid tumors receiving Platinum-based chemotherapy by recombinant human erythopoietin (rHuEPO): a prospective, open label, randomized trial by the Hellenic Cooperative Oncology Group. Oncology 64(2): 102-110, 2003. (citations: 31) 20.HP Kalofonos, D. Kardamakis, A. Bamias, D.V. Skarlos, P. Papakostas, D. Bafaloukos, A. Sakantamis, N. Pavlidis, G. Fountzilas. Adjuvant chemotherapy using CPT-11, Leucovorin plus bolus 5-Fluorouracil and Radiotherapy in patients with rectal cancer. A feasibility study. Anticancer Res 23: 1687-1692, 2003. (citations: 7) 21. Bamias AT, Bai MC, Agnantis NJ, Michael MC, Alamanos YP, Stefanaki SV, Razi ED, Skarlos DV, Kappas AM, Pavlidis NA. Prognostic significance of the deleted in colorectal cancer (DCC) gene expression in high risk resected gastric carcinoma. Cancer Invest 21(3): 333-340, 2003. (citations: 4) 22. A. Bamias, M. Chorti, C. Deliveliotis, N. Trakas, A. Skolarikos, B. Protogerou, S. Legaki, G. Tsakalou, N. Tamvakis, M.A. Dimopoulos. The prognostic significance of CA 125, CD44 and Epithelial Membrane Antigen (EMA) in renal cell carcinoma. Urology 62(2); 368-373, 2003. (citations: 11) 13 23.A. Bamias, D. Papamichael, K. Syrigos, N. Pavlidis. Phase II study of irinotecan and mitomycin C in 5-Fluorouracil pretreated patients with advanced colorectal and gastric cancer. J Chemother 15(3): 275-81, 2003. (citations: 11) 24.A. Bamias, G. Aravantinos, Ch. Deliveliotis, D. Bafaloukos, Ch. Kalofonos, N. Xiros, A. Zervas, D. Mitropoulos, E. Samantas, D. Pectasides, P. Papakostas, D. Gika, C. Kourousis, A. Koutras, C. Papadimitriou, C. Bamias, P. Kosmidis, M.A. Dimopoulos. Docetaxel and Cisplatin with Granulocyte-colony stimulating factor (G-CSF) versus M-VAC with G-CSF in advanced urothelial carcinoma: a multicenter, randomised, phase III study conducted by the Hellenic Cooperative Oncology Group. J Clin Oncol 22(2): 220-228, 2004. (citations: 91) 25.H.P. Kalofonos, D. Skarlos, D. Bafaloukos, P. Papakostas, A. Bamias, J. Janinis, E. Timotheadou, G. Kouvatseas, M. Stavropoulos, T. Economopoulos, G. Fountzilas. A phase II study with CPT-11 plus Leucovorin and bolus iv 5-Fluorouracil in patients with advanced colorectal carcinoma. Cancer Investigation 21(6): 855-862, 2003. (citations: 8) 26.A. Bamias, M.A. Dimopoulos. Angiogenesis in human cancer: implications in cancer therapy. Eur J Int Med 14: 459-469, 2003. (citations: 26) 27.Athanasios Protopapas, Emmanuel Diakomanolis, Aristotle Bamias, Spyros Milingos, Sonia Markaki, Christos Papadimitriou, AthanasiosMeletios Dimopoulos, Stylianos Michalas. The prognostic significance of the immunohistochemical expression of p53, bcl-2, c-erb-2 and cathepsinD in ovarian cancer receiving platinum with cyclophosphamide or paclitaxel chemotherapy. Eur J Gynaec Oncol 25: 225-229, 2004. (citations: 18) 28.Bamias A, Deliveliotis Ch, Aravantinos G, Kalofonos Ch, Karayannis A, Dimopoulos MA. Adjuvant chemotherapy with Paclitaxel and Carboplatin in patients with advanced bladder cancer: a study by the Hellenic Cooperative Oncology Group. J Urol, 171(4): 1467-1470, 2004. (citations: 13) 29.A. Bamias, Ch. Deliveliotis, G. Fountzilas, D. Gika, A. Anagnostopoulos, M.P. Zorzou, E. Kastritis, C. Konstantinidis, P. Kosmidis, M.A. Dimopoulos. Adjuvant chemotherapy with Paclitaxel and Carboplatin in patients with advanced carcinoma of the upper urinary tract: a study by the Hellenic Cooperative Oncology Group. J Clin Oncol 22: 2150-2154, 2004. (citations: 31) 30.Zorzou MP, Stratigos A, Efstathiou E, Bamias A. Exacerbation of Psoriasis after Treatment with an EGFR Tyrosine Kinase Inhibitor. Acta Derm Venereol 2004; 84: 308-309 (Letter). (citations: 13) 31.V. Eleutherakis – Papaiakovou, A. Bamias, MA. Dimopoulos. Thalidomide in cancer medicine. Ann Oncol 15:1151-1160, 2004. (citations: 45) 14 32.Protogerou V, Moschou M, Antoniou N, Varkarakis J, Bamias A, Deliveliotis C. Modified S-pouch neobladder vs ileal conduit and a matched control population: a quality-of-life survey. BJU Int 94: 350-354, 2004. (citations: 19) 33.A. Bamias, C. Deliveliotis, A. Karayiannis, I. Varkarakis, I. Zervas, D. Pantazopoulos, D. Gika, M.A. Dimopoulos. Neoadjuvant chemotherapy with Docetaxel and Cisplatin in patients with high-risk respectable bladder carcinoma: long term results. Eur Urol 46: 344-351, 2004. (citations: 7) 34.Helena Linardou, Gerassimos Aravantinos, Eleni Efstathiou, Charalambos Kalofonos, Athanasios Anagnostopoulos, Charalambos Deliveliotis, Dimitrios Bafaloukos, Meletios Athanasios Dimopoulos, Aristotelis Bamias. Gemcitabine and Carboplatin combination as first-line treatment in elderly and unfit for cisplatin-based chemotherapy patients with advanced bladder carcinoma. A phase II study of the Hellenic Co-operative Oncology Group. Urology, 64(3):479-484, 2004. (citations: 44) 35.MA Dimopoulos, C Papadimitriou, G Hamilos, E Efstathiou, G Vlahos, A Rodolakis, G Aravantinos, HP Kalofonos, C Kouroussis, D Gika, D Skarlos, A Bamias. Treatment of Ovarian Germ Cell Tumors with a three-day bleomycin, etoposide and cisplatin regimen: A prospective multicenter study. Gynecol Oncol 93: 695-700, 2004. (citations: 14) 36.Bamias A, Syrigos K, Fountzilas G, Tzamakou E, Soulti K, Karavasilis V, Alamanos Y, Christodoulou C, Pavlidis N. Intensified Bimonthly Cisplatin With Bolus 5-Fluorouracil, Continuous 5-Fluorouracil and High-Dose Leucovorin (LV5FU2) in Patients With Advanced Gastrointestinal Carcinomas: A Phase I Dose-Finding and Pharmacokinetic Study. Am J Clin Oncol 27: 465-471, 2004. (citations: 2) 37.Aristotle Bamias, Meletios A. Dimopoulos. Thalidomide and Immunomodulary drugs in the treatment of cancer. Expert Opin Invest Drugs 14: 45-55, 2005. (citations: 19) 38.E. Efstathiou, G. Bozas, A. Kostakopoulos, E. Kastritis, Ch. Deliveliotis, N. Antoniou, D. Skarlos, C. Papadimitriou, M.A. Dimopoulos, A. Bamias. Combination of Docetaxel, Estramustine Phosphate and Zoledronic acid in androgen independent metastatic prostate cancer: efficacy, safety and clinical benefit assessment. Urology 65:126-130, 2005. (citations: 23) 39.Aristotle Bamias, Eleni Efstathiou, Lia A. Moulopoulos, Dimitra Gika, George Hamilos, Markela P. Zorzou, Constantina Kakoyiannis, Efstathios Kastritis, George Bozas, Christos Papadimitriou, Meletios A. Dimopoulos. The outcome of elderly patients with advanced urothelial carcinoma after platinum-based combination chemotherapy. Ann Oncol 16:307-313, 2005. (citations: 19) 40.C. Christodoulou, D. Bafaloukos, E. Linardou, G. Aravantinos, A. Bamias, C. Karina, G. Klouvas, D. Skarlos. Temozolomide (TMZ) combined with 15 cisplatin (CDDP) in patients with brain metastases from solid tumors: Phase II study. J Neurooncol 71:61-65, 2005. (citations: 41) 41.Deliveliotis Ch, Georgoulakis J, Skolarikos A, Trakas N, Varkarakis J, Albanis S, Protogerou B, Bamias A. DNA ploidy as a prognostic factor in muscle invasive transitional cell carcinoma of the bladder. Urol Res 33: 3943, 2005. (citations: 8) 42.Markela P. Zorzou, Eleni Efstathiou, Eleni Galani, Georgios Bozas, Efstathios Kastritis, Christos Papadimitriou, Meletios A. Dimopoulos, Aristotle Bamias. Carboplatin hypersensitivity reactions: a single insitution experience. J Chemother 17:104-10, 2005. (citations: 6) 43. N. Xiros, P. Papakostas, T. Ecomopoulos, G. Samelis, E. Efstathiou, E. Kastritis, HP. Kalofonos, A. Onyenadum, D. Skarlos, A. Bamias, H. Gogas, D. Bafaloukos, E. Samantas, P. Kosmidis. Carboplatin plus Gemcitabine in patients with inoperable or metatstatic pancreatic cancer. A phase II multicenter study by the Hellenic Cooperative Oncology Group. Ann Oncol 16: 773-779, 2005. (citations: 12) 44.Kalofonos HP, Aravantinos G, Kosmidis P, Papakostas P, Economopoulos T, Dimopoulos M, Skarlos D, Bamias A, Pectasides D, Chalkidou S, Karina M, Koutras A, Samantas E, Bacoyiannis C, Samelis GF, Basdanis G, Kalfarentzos F, Fountzilas G. Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II study. Ann Oncol 16(6): 869877, 2005. (citations: 32) 45.George Chamilos, Aristotle Bamias, Eleni Efstathiou, Pagona M. Zorzou, Efstathios Kastritis, Evagelos Kostis, Christos Papadimitriou, Meletios A. Dimopoulos. Outpatient treatment of low-risk neutropenic fever in cancer patients, with oral moxifloxacin. Cancer 103(12):2629-2635, 2005. (citations: 34) 46.Evangelos Briasoulis, Epameinondas Samantas, Haralambos Kalofonos, Dimosthenis Skarlos, Thomas Makatsoris, Christos Cristodoulou, George Fountzilas, Aristotle Bamias, Athanasios-Meletios Dimopoulos, Paris Kosmidis, Nicholas Pavlidis. Phase I study of etoposide, cisplatin and irinotecan triplet in patients with advanced stage small cell lung cancer. Cancer Chem Pharmacol 56(5):521-528, 2005. (citations: 4) 47.Skolarikos A, Alivizatos G, Bamias A, Mitropoulos D, Ferakis N, Deliveliotis C, Dimopoulos MA. Bcl-2 protein and DNA ploidy in renal cell carcinoma: Do they affect patient prognosis? Int J Urol 12(6):563-569, 2005. (citations: 2) 48.Aristotle Bamias, Georgios Hamilos, Eleni Efstathiou, Maria Vassilakopoulou, Christos Papadimitriou, Alexandros Rodolakis, Dimitrios Mitsibounas, Georgios Vlahos, Meletios A. Dimopoulos. Late relapse of 16 epithelial ovarian cancer: a single institution experience. Eur J Gynecol Oncol 26: 439-442, 2005. 49.G. Fountzilas, C. Tolis, A. Kalogera-Fountzila, D. Misailidou, P. Tsekeris, M. Karina, A. Nikolaou, E. Samantas, T. Makatsoris, E. Athanassiou, D. Skarlos, A. Bamias, N Zamboglou, T Economopoulos, S Karanastassi, N Pavlidis, J Daniilidis. Paclitaxel, cisplatin, leucovorin and coninuous infusion fluorouracil followed by concomitant chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck. A Hellenic Cooperative Oncology Group Phase II study. Med Oncol 22: 269-279, 2005. (citations: 7) 50.Aristotle Bamias, George Basdanis, Ioannis Xanthakis, Nicholas Pavlidis, George Fountzilas. Prognostic factors in patients with colorectal cancer receiving adjuvant chemotherapy or chemoradiotherapy: a pooled analysis of two randomized studies. Int J Gastrointest Cancer 36:29-38, 2005. (citations: 1) 51.E. Kastritis, A. Bamias, E. Efstathiou, D. Gika, G. Bozas, MP. Zorzou, K. Sarris, C. Papadimitriou, MA Dimopoulos. The outcome of advanced or recurrent non-squamous carcinoma of the uterine cervix after platinumbased combination chemotherapy. Gynecol Oncol 99: 376-382, 2005. (citations: 12) 52. Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, Koutsoukou V, Gika D, Anagnostopoulos A, Papadimitriou C, Terpos E, Dimopoulos MA. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol 23: 8580-8587, 2005. (citations: 489) 53.Psyrri A, Bamias A, Yu Z, Weinberger PM, Kassar M, Markakis S, Kowalski D, Efstathiou E, Camp RL, Rimm DL, Dimopoulos MA. Subcellular Localization and Protein Levels of Cyclin-Dependent Kinase Inhibitor p27 independently Predict for Survival in Epithelial Ovarian Cancer. Clin Cancer Res. 11: 8384-8390, 2005. (citations: 18) 54.Bamias A, Dimopoulos MA. Neoadjuvant chemotherapy in invasive bladder cancer. Expert Rev Anticancer Ther. 5: 993-1000, 2005. 55.Psyrri A, Kassar M, Yu Z, Bamias A, Weinberger PM, Markakis S, Kowalski D, Camp RL, Rimm DL, Dimopoulos MA. Effect of epidermal growth factor receptor expression level on survival in patients with epithelial ovarian cancer. Clin Cancer Res. 11(24):8637-8643, 2005. (citations: 56) 56.Bozas GT, Bamias A, Kastritis E, Rodolakis A, Vlahos G, Papadimitriou CA, Markaki S, Dimopoulos MA. Adjuvant chemotherapy with paclitaxel and carboplatin in non-endometrioid carcinoma of the uterus. Eur J Gynaecol Oncol; 26: 627-631, 2005. (citations: 5) 17 57.Bozas G, Anagnostou D, Tassidou A, Moulopoulos LA, Bamias A, Dimopoulos MA. Extranodal non-Hodgkin’s lymphoma presenting as an abdominal wall mass. A case report and review of the literature. Leukemia & Lymphoma 47: 329-332, 2006. (citations: 4) 58.A. Bamias, L.A. Moulopoulos, A. Koutras, G. Aravantinos, G. Fountzilas, D. Pectasides, E. Kastritis, D. Gika, D. Skarlos, H. Linardou, H.P.Kalofonos, M.A. Dimopoulos. Gemcitabine and Carboplatin combination as first-line treatment in patients with advanced urothelial carcinoma. A phase II study of the Hellenic Co-operative Oncology Group. Cancer 106: 297-303, 2006. (citations: 28) 59.Bamias A, Dimopoulos MA. Inhibition of angiogenesis: common theme for cancer and atheromatosis? Hellenic J Cardiol 47(1):11-12, 2006. 60.Papakostas P, Tsavdaridis D, Kosmidis P, Kalofonos HP, Sakantamis A, Janinis D, Skarlos D, Bafaloukos D, Bamias A, Xiros N, Fountzilas G. Combination docetaxel (Taxotere), fluorouracil, and leucovorin (TFL), as first-line chemotherapy in advanced gastric cancer: a Hellenic Cooperative Oncology Group phase II study. Gastric Cancer 9: 26-31, 2006. (citations: 5) 61.M. Skopeliti, IF Voutsas, P. Klimenzou, M. Tsiatas, A. Beck, A. Bamias, M. Moraki, E. Livaniou, M. Neagu, W. Voelter, OE Tsitsilonis. The immunologically active site of prothymosin a is located at the carboxyterminus of the polypeptide. Evaluation of its in vitro effects in cancer patients. Cancer Immunol Immunother 55: 1247-1257, 2006. (citations: 11) 62.Ioanna Dimopoulou, Aristotelis Bamias, Panagiotis Lyberopoulos, Meletios A. Dimopoulos. Pulmonary toxicity from novel antineoplastic agents. Ann Oncol 17: 372-379, 2006. (citations: 31) 63.Aristotle Bamias, Ioannis Tiliakos, Maria-Dionysia Karali, Meletios A. Dimopoulos. Systemic chemotherapy in inoperable or metastatic bladder cancer. Ann Oncol 17: 553-561, 2006. (citations: 19) 64.Evangelos Terpos, Athanasios Anagnostopoulos, Efstathios Kastritis, Aristotelis Bamias, Konstantinos Tsionos, Meletios-Athanassios Dimopoulos. Abnormal bone remodelling and increased levels of macrophage inflammatory protein-1 alpha (MIP-1a) in Waldenstrom macroglobulinaemia. Br J Haematol 133: 301-304, 2006. (citations: 7) 65.Bozas G, Tassidou A, Moulopoulos LA, Constandinidis C, Bamias A, Dimopoulos MA. Non-Hodgkin’s Lymphoma of the renal pelvis. Clin Lymphoma & Myeloma 6:404-406, 2006. (citations: 2) 66.Psyrri A, Yu Z, Bamias A, Weinberger PM, Markakis S, Kowalski D, Camp RL, Rimm DL, Dimopoulos MA. Evaluation of the prognostic value of cellular inhibitor of apoptosis protein in epithelial ovarian cancer using 18 automated quantitative protein analysis. Cancer Epidemiol Biomarkers Prev 2006;15:1179-1183. (citations: 2) 67.E.Kastritis, E. Efstathiou, D. Gika, G. Bozas, V. Koutsoukou, C. Papadimitriou, G. Pissakas, M.A. Dimopoulos, A. Bamias. Brain metastases as isolated site of relapse in patients with epithelial ovarian cancer previously treated with platinum and paclitaxel-based chemotherapy. Int J Gynecol Cancer 2006; 16: 994-999. (citations: 7) 68.E. Kastritis, L.A. Moulopoulos, E. Politi, E. Kostis, G. Pissakas, M.A. Dimopoulos, A. Bamias. Intramedullary spinal cord and leptomeningeal metastases in a patient with carcinoma of the uterine cervix. Gynecol Oncol 2006; 102: 124-127. (citations: 7) 69.Aristotle Bamias, Alexandros Rodolakis, Meletios A. Dimopoulos. Current treatment of relapsed ovarian cancer. CCTR 2006; 2: 211-221. 70.George Bozas, Meletios A. Dimopoulos, Efstathios Kastritis, Eleni Efstathiou, Vassiliki Koutsoukou, Alexandros Rodolakis, George Vlahos, Zannis Voulgaris, Theoharis Papageorgiou, Dimitra Gika, Christos Papadimitriou, Aristotle Bamias. Young age is associated with favorable characteristics but is not an independent prognostic factor in patients with epithelial ovarian cancer (EOC): a single intitution experience. Oncology 2006; 70: 265-272. (citations: 6) 71.Dimopoulos MA, Kastritis E, Anagnostopoulos A, Melakopoulos I, Gika D, Moulopoulos LA, Bamia C, Terpos E, Tsionos K, Bamias A. Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acid. Haematologica 2006;91:968-971. (citations: 150) 72.Aristotle Bamias, Christos Papadimitriou, Eleni Efstathiou, Alexandros Rodolakis, Georgios Vlahos, Zannis Voulgaris, Georgios Bozas, Georgios Fountzilas, Gerassimos Aravantinos, Evagelia Razis, Dimitra Gika, Meletios A. Dimopoulos. Four cycles of Paclitaxel and Carboplatin as adjuvant treatment in early-stage ovarian cancer: a six-year experience of the Hellenic Cooperative Oncology Group. BMC Cancer 2006; 6: 228. (citations: 3) 73.George Fountzilas, Pavlos Papakostas, Urania Dafni, Thomas Makatsoris, Maria Karina, Anna Kalogera-Fountzila, Nicholaos Maniadakis, Gerasimos Aravantinos, Konstantinos Syrigos, Aristotelis Bamias, Christos Christodoulou, Theofanis Economopoulos, Haralabos P. Kalofonos, Angelos Nikolaou, Nikos Angouridakis, George Stathopoulos, Dimitrios Bafaloukos, Nicholas Pavlidis, John Daniilidis. Paclitaxel and Gemcitabine vs Paclitaxel and Pegylated Liposomal Doxorubicin in advanced non– nasopharyngeal head and neck cancer. An efficacy and cost analysis randomized study conducted by the Hellenic Cooperative Oncology Group. Ann Oncol 2006; 1560-1567. (citations: 7) 19 74.L. Kostadima, G. Pentheroudakis, M.A. Dimopoulos, D. Pectasides, H. Gogas, U. Stropp, Ch.Christodoulou, E. Samantas, R. Wirtz, G. Hennig, D. Bafaloukos, P. Arapantoni, H.P. Kalofonos, P.Papakostas, T. Economopoulos, A. Bamias, G. Fountzilas, N. Pavlidis. Survivin and Glycodelin transcriptional activity in node-positive early breast cancer: mRNA expression of two key regulators of cell survival. Breast Cancer Res Treat 2006; 100: 161-167. (citations: 2) 75. Kastritis E, Dimopoulos MA, Antoniou N, Deliveliotis C, Chrisofos M, Skolarikos A, Gika D, Bamias A. The outcome of patients with advanced pure squamous or mixed squamous and transitional urothelial carcinomas following platinum-based chemotherapy. Anticaner Res 2006; 26:38653869. (citations: 8) 76.G Mountzios, G Pavlakis, E Terpos, G Sakorafas, K Revelos, A Bamias, N Nikolaou, P Papasavas, J-C Soria and MA Dimopoulos. Concurrent development of testicular seminoma and choriocarcinoma of the superior mediastinum, presented as cervical mass: a case report and implications about pathogenesis of germ-cell tumours. BMC Pathology 2006; 6: 8. (citations: 2) 77.Aristotle Bamias, Ziwei Yu, Paul M. Weinberger, Sofia Markakis, Diane Kowalski, Robert L. Camp, David L. Rimm, Meletios A. Dimopoulos and Amanda Psyrri. Automated Quantitative Analysis of DCC Tumor Suppressor Protein in Ovarian Cancer Tissue Microarray Shows Association with β-catenin Levels and Outcome in Patients with Epithelial Ovarian Cancer. Ann Oncol 2006; 17: 1797-1802. (citations: 4) 78.Efstathios Kastritis, Georgios Bozas, Vassiliki Koutsoukou, Zannis Voulgaris, Georgios Vlahos, Alexandros Rodolakis, Dimitra Gika; Christos Papadimitriou, Meletios-Athanasios Dimopoulos, Aristotle Bamias. The impact of age in the outcome of patients with advanced or recurrent cervical cancer after platinum based chemotherapy. Gynecol Oncol 2007; 104: 372-376. (citations: 5) 79.George Bozas, Aristotle Bamias, Vassiliki Koutsoukou, Eleni Efstathiou, Dimitra Gika, Christos A. Papadimitriou, Meletios A. Dimopoulos. Biweekly Gemcitabine and Cisplatin in Platinum Resistant/Refractory, PaclitaxelPretreated, Ovarian and Peritoneal Carcinoma. Gynecol Oncol 2007; 104: 580–585. (citations: 11) 80.Eleutherakis-Papaiakovou V, Bamias A, Gika D, Simeonidis A, Pouli A, Anagnostopoulos A, Michali E, Economopoulos T, Zervas K, Group MA. Renal failure in multiple myeloma: Incidence, correlations, and prognostic significance. Leuk Lymphoma 2007 48(2):337-41. (citations: 43) 81.Giannis Mountzios, Meletios-Athanassios Dimopoulos, Aristotelis Bamias, George Papadopoulos, Efstathios Kastritis, Konstantinos Syrigos, George Pavlakis, EvangelosTerpos. Abnormal bone remodeling process is due to an imbalance in the Receptor Activator of Nuclear Factor–kB Ligand 20 (RANKL)/Osteoprotegerin (OPG) axis in patients with solid tumors metastatic to the skeleton. Acta Oncologica 2007;46(2):221-9. (citations: 25) 82.Eleni Efstathiou, Meletios A. Dimopoulos, George Bozas, Efstathios Kastritis, Lia A. Moulopoulos, Alexandros Rodolakis, George Vlahos, Dimitra Gika, Christos Papadimitriou, Aristotelis Bamias. Advanced Epithelial Ovarian Cancer in the Elderly: Chemotherapy Tolerance and Outcome. Anticancer Res 2007; 27(1B):611-7. (citations: 4) 83.CA Papadimitriou, Zorzou MP, Markaki S, A Rodolakis, Z Voulgaris, G Bozas, E Kastritis, A Bamias, D Gika, MA Dimopoulos. Anthracyclinebased adjuvant chemotherapy in early-stage uterine sarcomas: long-term results of a single institution experience. Eur J Gynaec Oncol 2007; 18: 109-116. (citations: 5) 84.Kastritis E, Anagnostopoulos A, Roussou M, Gika D, Matsouka C, Barmparousi D, Grapsa I, Psimenou E, Bamias A, Dimopoulos MA. Reversibility of renal failure in newly diagnosed multiple myeloma patients treated with high dose dexamethasone-containing regimens and the impact of novel agents. Haematologica 2007;92(4):546-9. (citations: 57) 85.Aristotle Bamias, Marinos Tsiatas, Eutychia Kafantari, Christina Liakos, Alexandros Rodolakis, Zannis Voulgaris, George Vlahos, Theocharis Papageorgiou, Ourania Tsitsilonis, Christina Bamia, George Papatheodoridis, Ekaterini Politi, Athanasios Archimandritis, Aristidis Antsaklis, Meletios A Dimopoulos. Significant differences of lymphocytes isolated from ascites of patients with ovarian cancer compared to blood and tumor lymphocytes. Association of CD3+CD56+ cells with platinum resistance. Gynecol Oncol 2007; 106: 75-81. (citations: 15) 86.Aristotle Bamias. Case Report 1. Sunitinib malate in patients with preexisting haematological abnormalities. Eur J Cancer 2007; 7(Suppl 5): 2829. 87.H Gakiopoulou, P Korkolopoulou, G Levidou, I Thymara, A Saetta, C Piperi, N Givalos, I Vassilopoulos, K Ventouri, A Tsenga, A Bamias, M-A Dimopoulos, E Agapitos and E Patsouris. Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications. Br J Cancer 2007; 98: 1124-1134. (citations: 7) 88.Athanasios Anagnostopoulos, Vangelis Eleftherakis-Papaiakovou, Konstantinos Zervas, Efstathios Kastritis, Konstantinos Tsionos, Aristotelis Bamias, John Meletis, Meletios A. Dimopoulos, Evangelos Terpos. Serum concentrations of angiogenic cytokines in Waldenstrom’s Macroglobulinaemia: the ratio of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity. Br J Haematol 2007; 137: 560568. (citations: 14) 21 89.Bamias A. Editorial Comment on: Impact of Multimodal Treatment on Survival in Patients with Metastatic Urothelial Cancer. Eur Urol 2007; 52: 1113-1114. 90.Pectasides D, Fountzilas G, Aravantinos G, Bamias A, Kalofonos HP, Skarlos D, Briasoulis E, Konstantara A, Economopoulos T, Dimopoulos MA. Epithelial ovarian carcinoma in younger vs older women: is age an independent prognostic factor? The Hellenic Oncology Cooperative Group experience. Int J Gynecol Cancer. 2007; 17: 1003-1010. (citations: 12) 91.Aristotelis Bamias, Gerassimos Aravantinos, Charalambos Deliveliotis, Anastasios Thanos, George Klouvas, Nikolaos Antoniou, Iraklis Poulias, Thomas Makatsoris, Epaminondas Samantas, Meletios A. Dimopoulos. Two Cycles of Etoposide/Cisplatin Cure All Patients with Stage I Testicular Seminoma: A Risk Adapted Protocol of the Hellenic Cooperative Oncology Group. Urology 2007; 70: 1179-1183. 92.Giannis Mountzios, Aristotelis Bamias, Zannis Voulgaris, Alexandros Rodolakis, Georgios Vlahos, GM Gourgoulis, Evangelos EleftherakisPapaiakovou, A. Giannopoulos. Prognostic factors in patients treated with Taxane-based chemotherapy for recurrent or metastatic endometrial cancer: Proposal for a new prognostic model. Gynecol Oncol 2008; 108: 130-135. (citations: 9) 93.Kosmidis PA, Kalofonos HP, Christodoulou C, Syrigos K, Makatsoris T, Skarlos D, Bakogiannis C, Nicolaides C, Bafaloukos D, Bamias A, Samantas E, Xiros N, Boukovinas I, Fountzilas G, Dimopoulos MA. Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group. Ann Oncol 2008; 19: 115-122. (citations: 25) 94.Aristotle Bamias, George Bozas, Nikolaos Antoniou, Iraklis Poulias, Harilaos Katsifotis, Andreas Skolarikos, Dimitrios Mitropoulos, Christos Alamanis, Gerassimos Alivizatos, Haralambos Deliveliotis, Meletios A. Dimopoulos. Prognostic and predictive factors in patients with androgenindependent prostate cancer treated with docetaxel and Estramustine: a single institution experience. Eur Urol 2008; 53: 323-332. (citations: 13) 95.Aristotle Bamias, Vassiliki Koutsoukou, Evangelos Terpos, Christina Liakos, Marinos L Tsiatas, Ourania Tsitsilonis, Alexandros Rodolakis, Zannis Voulgaris, George Vlahos, Theocharis Papageorgiou, George Papatheodoridis, Athanasios Archimandritis, Aristidis Antsaklis, Meletios A Dimopoulos. Correlation of NK-T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFa in ascites from advanced ovarian cancer: association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapy. Gynecol Oncol 2008; 108:421-427.(citations: 21) 22 96.Bamias A, Dimopoulos MA. Editorial Comment on: New treatment approaches for prostate cancer based on peptide analogues. Eur Urol. 2008; 899-900. 97.Papadimitriou C, Dafni U, Anagnostopoulos A, Vlachos G, Voulgaris Z, Rodolakis A, Aravantinos G, Bamias A, Bozas G, Kiosses E, Gourgoulis GM, Efstathiou E, Dimopoulos MA. High-dose melphalan and autologous stem cell transplantation as consolidation treatment in patients with chemosensitive ovarian cancer: results of a single-institution randomized trial. Bone Marrow Transplant 2008; 41: 547-554. (citations: 8) 98.A. Bamias, G. Fountzilas, M. Michael, C. Konstantaras, E. Vrettou, E. Eleftheriadis, P. Papakostas, K. Papadimitriou, N. Pavlidis, N. Xiros, M. Bai. DCC and TS protein expression in resected gastric cancer: a Hellenic Cooperative Oncology Group study. CEJMed 2008; 3: 29-39. 99.Aristotle Bamias, George Lainakis, Efstathios Kastritis, Nikos Antoniou, Gerassimos Alivizatos, Andreas Koureas, Michael Chrisofos, Andreas Skolarikos, Evangelos Karayiotis, Meletios A. Dimopoulos. Biweekly Carboplatin/Gemcitabine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy. Report of efficacy, quality of life and geriatric assessment. Oncology 2007; 73: 290-297. (citations: 9) 100.Papadimitriou, Papakostas, Timotheadou, Aravantinos, Bamias, Fountzilas. Adjuvant Dose-Dense Sequential Chemotherapy with Epirubicin, CMF and Weekly Paclitaxel in Patients with Resected High-Risk Breast Cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study. Cancer Invest 2008;26:491-8. (citations: 2) 101.Briasoulis E, Fountzilas G, Bamias A, et al. Multicenter phase II trial of irinotecan plus oxaliplatin [IROX regimen] in patients with poor-prognosis cancer of unknown primary. A Hellenic Cooperative Oncology Group study. Cancer Chemother Pharmacol 2008 ;62(2):277-84. (citations: 5) 102.George Lainakis, Antoniou Nikos, Alivizatos Gerassimos, Chrisofos Michael, Mitsoyiannis Iraklis, Livadas Konstantinos, Varkarakis Ioannis, Katsifotis Harilaos, Meletios A. Dimopoulos, Aristotelis Bamias. Biweekly Doxorubicin/Ketokonazole as second-line treatment in docetaxel-resistant, hormone-refractory prostate cancer (HRPC). Urology 2008;71(6):1181-5. (citations: 1) 103.A. Bamias, F. Kyriakou, M. Chorti, et al. Microvessel Density (MVD) and Cyclooxygenase-2 (COX-2)/ β-catenin Interaction are Associated with Relapse in Patients with Transitional Carcinoma Receiving Adjuvant Chemotherapy with Paclitaxel/Carboplatin: a Hellenic Cooperative Oncology Group (HECOG) Study. Anticancer Res 2008; 28:2479-86. (citations: 2) 104.Papadimitriou CA, Fountzilas G, Bafaloukos D, Bozas G, Kalofonos H, Pectasides D, Aravantinos G, Bamias A, Dimopoulos MA. Paclitaxel, 23 topotecan, and carboplatin in metastatic endometrial cancinoma: A Hellenic Co-operative Oncology Group (HeCOG) study. Gynecol Oncol 2008;111:27-34. (citations: 3) 105.Kalofonos HP, Bamias A, Koutras A, Papakostas P, Basdanis G, Samantas E, Karina M, Misailidou D, Pisanidis N, Pentheroudakis G, Economopoulos T, Papadimitriou C, Skarlos DV, Pectasides D, Stavropoulos M, Bafaloukos D, Kardamakis D, Karanikiotis C, Vourli G, Fountzilas G. A randomised phase III trial of adjuvant radio-chemotherapy comparing Irinotecan, 5FU and Leucovorin to 5FU and Leucovorin in patients with rectal cancer: A Hellenic Cooperative Oncology Group Study. Eur J Cancer 2008;44:1693-700. (citations: 6) 106.Gerasimos Aravantinos; George Fountzilas; Aristotelis Bamias; Irene Grimani; Spyridon Rizos; Haralabos P Kalofonos; Dimosthenis V Skarlos; Theofanis Economopoulos; Paris A Kosmidis; George P Stathopoulos; Evangelos Briasoulis; Dimitrios Pectasides; Epaminondas Samantas; Eleni Timotheadou; Christos Papadimitriou; Alexandros Papanikolaou; Adimchi Onyenadum; Pavlos Papakostas; Dimitrios Bafaloukos; Meletios A Dimopoulos. Carboplatin and Paclitaxel versus Cisplatin, Paclitaxel and Doxorubicin for first line Chemotherapy of Advanced Ovarian Cancer. Eur J Cancer 2008; 44:2169-2177. (citations: 5) 107.Pentheroudakis G, Briasoulis E, Kalofonos HP, Fountzilas G, Economopoulos T, Samelis G, Koutras A, Karina M, Xiros N, Samantas E, Bamias A, Pavlidis N. Docetaxel and carboplatin combination chemotherapy as outpatient palliative therapy in carcinoma of unknown primary: A multicentre Hellenic Cooperative Oncology Group phase II study. Acta Oncol 2008; 3:1-8. (citations: 12) 108.Lainakis G, Bamias A.Targeting angiogenesis in renal cell carcinoma. Curr Cancer Drug Targets. 2008;8(5):349-58. (citations: 12) 109.Papadimitriou CA, Peitsidis P, Bozas G, Grimani I, Vlahos G, Rodolakis A, Lianos E, Bamias A, Lainakis G, Dimopoulos MA. Paclitaxel- and Platinum-Based Postoperative Chemotherapy for Primary Fallopian Tube Carcinoma: A Single Institution Experience. Oncology. 2008; 75(1-2):4248. (citations: 2) 110.Fitzpatrick JM, Anderson J, Sternberg CN, Fleshner N, Fizazi K, Rébillard X, Dogliotti L, Conti G, Turesson I, James N, Heidenreich A, Solsona E, Guillem V, Herchenhorn D, Moul J, van Moorselaar J, Coetzee LJ, Wilson A, Bamias A, De Wit R, Chrisofos M. Optimizing treatment for men with advanced prostate cancer: Expert recommendations and the multidisciplinary approach. Crit Rev Oncol Hematol. 2008; 68S: 9-22. (citations: 13) 111.Dellis AE, Demonakou M, Papatsoris AG, Chrisofos M, Bamias A, Deliveliotis C. Insight into long-term histological, proliferative and apoptotic 24 modifications in ileal orthotopic neobladder and conduit mucosa. Tumori. 2008 Sep-Oct;94(5):701-5. (citations: 2) 112.Dimopoulos MA, Kastritis E, Bamia C, Melakopoulos I, Gika D, Roussou M, Migkou M, Eleftherakis-Papaiakovou E, Christoulas D, Terpos E, Bamias A. Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Ann Oncol. 2009; 20(1):117-20. (citations: 84) 113.Efstathios Kastritis, Samuel Murray, Fani Kyriakou, Maria Horti, Nicolaos Tamvakis, Nicolaos Kavantzas, Efstratios S. Patsouris, Aphrodite Noni, Sofia Legaki, Meletios A. Dimopoulos, Aristotle Bamias. Somatic APC mutations and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication. Int J Cancer 2009; 124(1):103-8. (citations: 13) 114.Aristotle Bamias. Editorial Comment on: Can Tyrosine Kinase Inhibitors be Discontinued in Patients with Metastatic Renal Cell Carcinoma and a Complete Response to Treatment? A Multicentre, Retrospective Analysis. Eur Urol 2009; 55: 1439. 115.G. Fountzilas, A. Bamias, A. Kalogera-Fountzila, G. Karayiannopoulou, et al. Induction Chemotherapy with Docetaxel and Cisplatin Followed by Concomitant Chemoradiotherapy in Patients with Inoperable Nonnasopharyngeal Carcinoma of the Head and Neck . Anticaner Res 2009; 29: 529-538. (citations: 7) 116. Georgaki S, Skopeliti M, Tsiatas M, Nicolaou KA, Ioannou K, Husband A, Bamias A, Dimopoulos MA, Constantinou AI, Tsitsilonis OE. Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo. J Cell Mol Med 2009; 13: 3929-3938. (citations: 4) 117.Pectasides D, Papaxoinis G, Fountzilas G, Aravantinos G, Bamias A et al. Epithelial ovarian cancer in Greece: a retrospective study of 1,791 patients by the Hellenic Cooperative Oncology Group (HeCOG). Anticancer Res. 2009 Feb;29(2):745-51. (citations: 4) 118.Aristotle Bamias, George Lainakis, Efstathios Manios, Eleni Koroboki, Alexandra Karadimou, Nikos Zakopoulos and Meletios A. Dimopoulos. Could Rigorous Diagnosis and Management of Hypertension Reduce Cardiac Events in Patients With Renal Cell Carcinoma Treated With Tyrosine Kinase Inhibitors? J Clin Oncol 2009; 27(15):2567-9. (citations: 6) 119.Bamias A, Aravantinos G, Kastriotis I, Alivizatos G, Anastasiou I, Christodoulou C, Gyftaki R, Kalofonos HP, Dimopoulos MA. Report of the long-term efficacy of two cycles of adjuvant bleomycin/etoposide/cisplatin in patients with stage I testicular nonseminomatous germ-cell tumors (NSGCT): A risk adapted protocol of the Hellenic Cooperative Oncology Group. Urol Oncol. 2011; 29: 189-193. 25 120.Mountzios G, Dimopoulos MA, Bamias A, Vourli G, Kalofonos H, Aravantinos G, Fountzilas G, Papadimitriou CA. Randomized multicenter phase II trial of cisplatin and ifosfamide with or without paclitaxel in recurrent or metastatic carcinoma of the uterine cervix: a Hellenic Cooperative Oncology Group (HeCOG) study. Ann Oncol. 2009; 20: 13621368. (citations: 3) 121. Mountzios J, Bamias A. Cisplatin-based chemotherapy for advanced seminoma: report of 52 cases treated in two institutions. J Cancer Res Clin Oncol 2009 (in press). 122.A. Bamias, G. Lainakis, E. Manios, E. Koroboki, R. Gyftaki, N. Zakopoulos, M.A. Dimopoulos. Diagnosis and management of hypertension in advanced renal cell carcinoma: prospective evaluation of an algorithm in patients treated with Sunitinib. J Chemother 2009; 3: 347350. (citations: 5) 123.Lainakis G, Bamias A, Psimenou E, Fountzilas G, Dimopoulos MA. Sunitinib treatment in patients with severe renal function impairment: a report of four cases by the Hellenic Cooperative Oncology Group. Clin Nephrol. 2009;72(1):73-8. (citations: 5) 124.Marinos Tsiatas, Reveka Gyftaki, Cristine Liacos, Ekaterini Politi, Alexandros Rodolakis, Meletios-Athanasios Dimopoulos, Aristotelis Bamias. Study of T lymphocytes infiltrating peritoneal metastases in advanced ovarian cancer. Associations with VEGF levels and prognosis in patients receiving platinum-based chemotherapy. Int J Gynecol Cancer 2009; 1329-1334. (citations: 4) 125.Zagouri F, Papaefthimiou M, Chalazonitis AN, Antoniou N, Dimopoulos MA, Bamias A. Prostate Cancer with Metastasis to the Omentum and Massive Ascites: A Rare Manifestation of a Common Disease. Onkologie 2009;32(12):758-761. (citations: 1) 126.G. Mountzios, A. Bamias, A. Dalianis, P. Danias, E. Pantelidaki, J. Nanas, M.A. Dimopoulos. Endocardial metastases as the only site of relapse in a patient with bladder carcinoma: A case report and review of the literature. Int J Cardiol 2010; 140: E4-E7. (citations: 2) 127.Bafaloukos D, Linardou H, Aravantinos G, Papadimitriou C, Bamias A, Fountzilas G, Kalofonos HP, Kosmidis P, Timotheadou E, Makatsoris T, Samantas E, Briasoulis E, Christodoulou C, Papakostas P, Pectasides D, Dimopoulos AM. A randomized phase II study of carboplatin plus pegylated liposomal doxorubicin versus carboplatin plus paclitaxel in platinum sensitive ovarian cancer patients: a Hellenic Cooperative Oncology Group study. BMC Med. 2010;8(1):3. (citations: 6) 128.N. Gavalas, MA Dimopoulos, A. Bamias. Anti-tumor immune response in ovarian cancer: clinical implications, prognostic significance and potential 26 for novel treatment strategies. Oncol Rev DOI: 10.1007/s12156-009-00165. 129.Boskos CS, Liacos C, Korkolis D, Aygerinos K, Lamproglou I, Terpos E, Stoupa E, Baltatzis G, Beroukas K, Papasavvas P, Dimopoulos MA, Bamias A. Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancer. J Surg Oncol. 2010; 102: 408-412. (citations: 1) 130.Aristotle Bamias, Theodora Psaltopoulou, M. Sotiropoulou, Dimitrios Haidopoulos, Evangelos Lianos, Evangelos Bournakis, Christos Papadimitriou, A. Rodolakis, G. Vlahos, M. A. Dimopoulos. Mucinous But Not Clear Cell Histology Is Associated With Inferior Survival in Patients With Advanced Stage Ovarian Carcinoma Treated With Platinum-paclitaxel Chemotherapy. Cancer 2010; 116: 1462-8. (citations: 11) 131.A. Karadimou, MA Dimopoulos, A. Bamias. The role of high-dose chemotherapy in the treatment of testicular cancer. Open Access Journal of Urology 2010; 2: 25-30. (citations: 1) 132.Bozas G, Terpos E, Gika D, Karadimou A, Dimopoulos MA, Bamias A. Prechemotherapy Serum Levels of CD105, Transforming Growth Factor beta2, and Vascular Endothelial Growth Factor Are Associated With Prognosis in Patients With Advanced Epithelial Ovarian Cancer Treated With Cytoreductive Surgery and Platinum-Based Chemotherapy. Int J Gynecol Cancer 2010 20(2):248-54. 133.Ignace Vergote, Eric Pujade-Lauraine, Sandro Pignata, Gunnar B. Kristensen, Jonathan Ledermann, Antonio Casado, Jalid Sehouli, Mansoor Mirza, Roldano Fossati, Christian Marth, Carine Creutzberg, Jose Del Campo, Nadeem Siddiqui, Paula Calvert, Aris Bamias, Gokhan Tulunay, Ate G.J. van der Zee, and Andreas du Bois, MD,* on behalf of the member trial groups of the European Network of Gynaecological Oncological Trial Groups (ENGOT). European Network of Gynaecological Oncological Trial Groups’ Requirements for Trials Between Academic Groups and Pharmaceutical Companies. Int J Gynecol Cancer 2010;20: 476-478. 134.Aristotelis Bamias, Alexandra Karadimou, Sofia Lampaki, George Lainakis, Lia Malettou, Eleni Timotheadou, Kostas Papazisis, Charalambos Andreadis, Loukas Kontovinis, Ioannis Anastasiou, Kostas Stravodimos, Ioannis Xanthakis, Andreas Skolarikos, Christos Christodoulou, Kostas Syrigos, Christos Papandreou, Evangelia Razi, Urania Dafni, George Fountzilas, Meletios A Dimopoulos. Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model. BMC Cancer 2010; 10: 45. (citations: 3) 135.Mountzios G, Terpos E, Syrigos K, Papadimitriou C, Papadopoulos G, Bamias A, Mavrikakis M, Dimopoulos MA. Markers of bone remodeling and 27 skeletal morbidity in patients with solid tumors metastatic to the skeleton receiving the biphosphonate zoledronic acid. Transl Res. 2010;155(5):24755. (citations: 4) 136.Bamias A, Karina M, Papakostas P, Kostopoulos I, Bobos M, Vourli G, Samantas E, Christodoulou C, Pentheroudakis G, Pectasides D, Dimopoulos MA, Fountzilas G. A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer. Cancer Chemother Pharmacol 2010; 65: 1009-1021. (citations: 8) 137.Aristotle Bamias, Evangelos Terpos Meletios A. Dimopoulos. Avascular Osteonecrosis of the Jaw as a Side Effect of Bisphosphonate Treatment. Onkologie 2010; 33: 288-289 (Editorial). 138.Schmoll HJ, Jordan K, Huddart R, Pes MP, Horwich A, Fizazi K, Kataja V; ESMO Guidelines Working Group. Collaborators (63): Schmoll HJ, Laguna MP, Fizazi K, Horwich A, Albers P, Albrecht W, Algaba F, Bamias A, Bodrogi I, Cohn-Cedermark G, Culine S, Cullen M, Daugaard G, De Santis M, De Wit R, Derigs G, Dieckmann K, Droz JP, Einhorn L, Fléchon A, Fossa S, Foster RS, Solans JG, Gauler T, Géczi L, Lluch JR, Gillessen S, Gosporadowicz M, Hartmann M, Huddart R, Jewett M, Joffe J, Jordan K, Kataja V, Klepp O, Kollmannsberger C, Krege S, Looijenga L, Mead GM, Necchi A, Nichols C, Nicolai N, Oliver T, Ondrus D, Osterhuis W, Paz-Ares L, Powles T, Pottek T, Rajpert-De Meyts E, Rosti G, Rustin G, Salvioni R, Schmidberger H, Sedlmayer F, Sella A, Sippel C, Skakkebaek NE, Sohaib A, Tjulandin S, van den Belt-Dusebout AW, von der Maase H, Warde P, Wood L. Testicular non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010 May;21 Suppl 5:v147-54. (citations: 11) 139.Schmoll HJ, Jordan K, Huddart R, Pes MP, Horwich A, Fizazi K, Kataja V; ESMO Guidelines Working Group. Collaborators (63): Schmoll HJ, Laguna MP, Fizazi K, Horwich A, Albers P, Albrecht W, Algaba F, Bamias A, Bodrogi I, Cohn-Cedermark G, Culine S, Cullen M, Daugaard G, De Santis M, De Wit R, Derigs G, Dieckmann K, Droz JP, Einhorn L, Fléchon A, Fossa S, Foster RS, Solans JG, Gauler T, Géczi L, Lluch JR, Gillessen S, Gosporadowicz M, Hartmann M, Huddart R, Jewett M, Joffe J, Jordan K, Kataja V, Klepp O, Kollmannsberger C, Krege S, Looijenga L, Mead GM, Necchi A, Nichols C, Nicolai N, Oliver T, Ondrus D, Osterhuis W, Paz-Ares L, Powles T, Pottek T, Rajpert-De Meyts E, Rosti G, Rustin G, Salvioni R, Schmidberger H, Sedlmayer F, Sella A, Sippel C, Skakkebaek NE, Sohaib A, Tjulandin S, van den Belt-Dusebout AW, von der Maase H, Warde P, Wood L. Testicular seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010 May;21 Suppl 5:v140-6. (citations: 5) 140.Karadimou A, Lianos E, Pectasides D, Dimopoulos MA, Bamias A. Efficacy of methotrexate/vinblastine/doxorubicin/cisplatin combination in 28 gemcitabine-pretreated patients with advanced urothelial cancer: a retrospective analysis. Open Access Urology 2010; 2: 1-7. 141.Mattheos Bobos • Aristotelis Bamias. In response to Dr. Han’s comments. Cancer Chemother Pharmacol. 2010; DOI 10.1007/s00280-010-1491-x. 142.Papadimitriou CA, Papakostas P, Karina M, Malettou L, Dimopoulos MA, Pentheroudakis G, Samantas E, Bamias A, et al. A randomised phase III trial of adjuvant chemotherapy with irinotecan, leucovorin and fluorouracil versus leucovorin and fluorouracil for stage II and III colon cancer : A Hellenic Cooperative Oncology Group study. BMC Med 2011; 9: 10. (citations: 3) 143.Kontovinis L, Laschos K, Karadimou A, Andreadis C, Bamias A, Paraskevopoulos P, Dimopoulos M, Papazisis K. Sequential treatment with sorafenib and sunitinib in metastatic renal cell carcinoma : clnical outcomes from a retrospective clinical study. Med Oncol 2011. (citations: 1) 144.Bamias A, Gavalas NG, Karadimou A, Dimopoulos MA. Immune response in ovarian cancer: how is the immune system involved in prognosis and therapy: potential for treatment utilization. Clin Dev Immunol 2010; 2010: 791603 (Epub). (citations: 1) 145.George Lainakis, Alexandra Karadimou, Athanasios Meletios Dimopoulos, Aristotelis Bamias. Bevacizumab in the treatment Of metastatic renal cell carcinoma (mRCC). FCO 2010; Special Issue 1: 5057. 146.Mountzios I, Bournakis E, Efstathiou E, Varkaris A, Wen S, Chrisofos M, Deliveliotis C, Alamanis C, Anastasiou I, Constantinides C, Karadimou A, Tsiatas M, Papadimitriou C, Bamias A, Dimopoulos MA. Intermittent docetaxel chemotherapy in patients with castrate-resistant prostate cancer. Urology 2011; 77: 682-687. (citations: 3) 147.Bournakis E, Efstathiou E, Varkaris A, Wen S, Chrisofos M, Deliveliotis C, Alamanis C, anastassiou I, Constantinides C, Bamias A, Dimopoulos MA. Time to castration resistance is an independent predictor of castrationresistant prostate cancer survival. Anticancer Res 2011; 31: 1475-1482. 148.Ziogas AC, Gavalas N, Tsiatas M, Tsitsilonis O, Politi E, Terpos E, Rodolakis A, Vlahos G, Thomakos N, Haidopoulos D, Antsaklis A, Dimopoulos MA, Bamias A. VEGF directly suppresses activation of T cells from ovarian cancer patients and healthy individuals via VEGF receptor type 2. Int J Cancer 2012, 130: 857-864. 149.A. Bamias, E. Manios, A. Karadimou, F. Michas, G. Lainakis, C. Constantinidis, C. Deliveliotis, N. Zakopoulos, M.A. Dimopoulos. The use of 24-h ambulatory blood pressure monitoring (ABPM) during the first cycle of sunitinib improves the diagnostic accuracy and management of 29 hypertension in patients with advanced renal cancer. Eur J Cancer 2011, 47: 1660-1668, doi:10.1016/j.ejca.2011.03.03 (citations: 1) 150.Vassilakopoulou M, de la Motte Rouge T, Colin P, Ouzzane A, Khayat D, Dimopoulos MA, Papadimitriou CA, Bamias A, Pignot G, Nouhaud FX, Hurel S, Guy L, Bigot P, Roumiguié M, Rouprêt M; for the French collaborative national database on UUT-UCC. Outcomes after adjuvant chemotherapy in the treatment of high-risk urothelial carcinoma of the upper urinary tract (UUT-UC): Results From a Large Multicenter Collaborative Study. Cancer 2011; 117: 5500-5508. (citations: 1) 151.Bournakis E, Dimopoulos MA, Bamias A. Management of advanced bladder cancer in patients with impaired renal function. Expert Review of Anticancer Therapy 2011; 11: 931-939, doi 10.1586/era.10.197. 152.A. Bamias, A. Karadimou, N. Soupos, M. Sotiropoulou, F. Zagouri, D. Haidopoulos, N. Thomakos, A. Rodolakis, A. Antsaklis and M.A. Dimopoulos. Prognostic factors for early-stage epithelial ovarian cancer, treated with adjuvant carboplatin/paclitaxel chemotherapy: A single institution experience. Gynecol Oncol 2011; doi:10.1016/j.ygyno.2011.06.033. 153.Karadimou A, Migou M, Economidi A, Stratigos A, Kittas C, Dimopoulos MA, Bamias A. Leukocytoclastic vasculitis after long-term treatment with sunitinib: a case report. Case Rep Oncol 2011;4:385-391 (DOI: 10.1159/000331419). 154.A. Bamias, M. Sotiropoulou, F. Zagouri, P. Trachana, K. Sakellariou, E. Kostouros, K. Kakoyianni, A. Rodolakis, G. Vlahos, D. Haidopoulos, N. Thomakos, A. Antsaklis, M.A. Dimopoulos. Prognostic evaluation of tumour type and other histopathological characteristics in advanced epithelial ovarian cancer, treated with surgery and paclitaxel/carboplatin chemotherapy: Cell type is the most useful prognostic factor. Eur J Cancer 2011, doi:10.1016/j.ejca.2011.09.023. 155.Christodoulos Stefanadis, Andreas Synetos, Dimitris Tousoulis, Eleftherios Tsiamis, Archontoula Michelongona, Flora Zagouri, Aristotle Bamias, Meletios Athanasios Dimopoulos, Stella Kyvelou, Ioannis Kapelakis, Konstantinos Toutouzas. Systemic administration of bevacizumab increases the risk of cardiovascular events in patients with metastatic cancer. Int J Cardiol 2011, doi:10.1016/j.ijcard.2011.10.115. 156.Elias Athanassiadis, Vassilis Georgoulias, Charalampos Kalophonos, Paris Kosmidis, Aristotelis Bamias, Vassilios Barbounis, Ioannis Boukovinas, Dimitrios Pectasides, Epameinondas Samantas, Dimosthenis Skarlos; On behalf of non-infectious pneumonitis study group. Consensus on the better diagnosis, treatment and management of non-infectious pneumonitis. FCO 2011; 2: 37-39. 30 157.Morris DN, Bamias AT. Drugs for the treatment of advanced/metastatic renal cancer: Current perspectives Archives of Hellenic Medicine 2011; 28: 450-459. 158.Aristotle Bamias, Christina Bamia, Alexandra Karadimou, Nikolaos Soupos, Flora Zagouri, Alexandros Rodolakis, Dimitrios Haidopoulos, George Vlahos, Nikos Thomakos, Aristidis Antsaklis, Meletios A. Dimopoulos. A Risk-Adapted Strategy of Adjuvant Paclitaxel/Carboplatin in Early-Stage Ovarian Cancer: Time-Dependent Effect of 4 versus 6 Cycles on Outcome. Oncology 2012;81:365-371 (DOI: 10.1159/000334230). 159.I. Vergote, E. Pujade-Lauraine, S. Pignata, GB Kristensen. J Ledermann, A. Casado, J Sehouli, M. Mirza, R. Fossati, C. Marth, N ottevanger, J. Del campo, N. Siddiqui, P. Calvert, A. Bamias, G. Tulunay, AGJ Van der Zee, A. du Bois. The European Network of Gynaecological Oncological Trial Groups. Clin Invest 2012; 2: 35-37. 160.Emmanouil Panagiotidis, Ioannis Emmanouil Datseris, Demetrios Exarhos, Maria Skilakaki, Evangelia Skoura and Aristotelis Bamias. High incidence of peritoneal implants in recurrence of intra-abdominal cancer revealed by 18F-FDG PET/CT in patients with increased tumor markers and negative findings on conventional imaging. Nuclear Medicine Communications 2012 DOI: 10.1097/MNM.0b013e3283506ae1. 161.Nicolaou-Galitis O, Migkou M, Psyrri A, Bamias A, Pectasides D, Economopoulos T, Raber-Durlacher JE, Dimitriades G, Dimopoulos MA. Gingival bleeding and jaw bone necorosis in aptients with metastatic renal cell carcinoma receiving sunitinib: Report of 2 cases with clinical implications. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 2012; 113: 234-238. 162.Flora Zagouri, Nikolaos Thomakos, Alexandros Rodolakis, Aristotle Bamias, Athanassios Chalazonitis, Maria Sotiropoulou, Aris Antsaklis, Meletios-Athanassios Dimopoulos, Christos A. Papadimitriou. Quiz Case: A 19-Year-Old Woman with Hypercalcemia and Abdominal Pain. Onkologie 2012; 35: 126–127 (letter). 163.Stefanou DT, Episkopou H, Kyrtopoulos SA, Bamias A, Gkotzamanidou M, Bamia C, Liakou C, Bekyrou M, Sfikakis PP, Dimopoulos MA, Souliotis VL. Development and validation of a PCR-based assay for the selection of patients more likely to benefit from therapeutic treatment with alkylating drugs. Br J Clin Pharmacol 2012. doi: 10.1111/j.1365-2125.2012.04274.x. 164.Grünwald V, Karakiewicz PI, Bavbek SE, Miller K, Machiels JP, Lee SH, Larkin J, Bono P, Rha SY, Castellano D, Blank CU, Knox JJ, Hawkins R, Anak O, Rosamilia M, Booth J, Pirotta N, Bodrogi I; REACT Study Group. Collaborators (253) : ….Bamias A…... An international expanded-access programme of everolimus: addressing safety and efficacy in patients with metastatic renal cell carcinoma who progress after initial vascular 31 endothelial growth factor receptor-tyrosine kinase inhibitor therapy. Eur J Cancer. 2012;48:324-32. 165. Bamias A, Pignata S, Pujade-Lauraine E. Angiogenesis: A promising therapeutic target for ovarian cancer. Crit Rev Oncol/Hematol 2012, http://dx.doi.org/10.1016/j.critrevonc.2012.04.002 166. Thomakos N, Zacharakis D, Akrivos N, Zagouri F, Simou M, Bamias A, Dimopoulos MA, Rodolakis A, Antsaklis A. Merkel cell carcinoma in pelvic lymph nodes after surgical staging for endometrial cancer: A case report and review of the literature. Int J Surg Case Rep. 2012; 3: 340-342. 167. Levidou G, Ventouri K, Nonni A, Gakiopoulou H, Bamias A, Sotiropoulou M, Papaspirou I, Dimopoulos MA, Patsouris E, Korkolopoulou P. Replication Protein A in Nonearly Ovarian Adenocarcinomas: Correlation With MCM-2, MCM-5, Ki-67 Index and Prognostic Significance. Int J Gynecol Pathol. 2012;31:319-27. 168. Colombo N, Kutarska E, Dimopoulos M, Bae DS, Rzepka-Gorska I, Bidzinski M, Scambia G, Engelholm SA, Joly F, Weber D, El-Hashimy M, Li J, Souami F, Wing P, Engelholm S, Bamias A, Schwartz P. Randomized, OpenLabel, Phase III Study Comparing Patupilone (EPO906) With Pegylated Liposomal Doxorubicin in Platinum-Refractory or -Resistant Patients With Recurrent Epithelial Ovarian, Primary Fallopian Tube, or Primary Peritoneal Cancer. J Clin Oncol. 2012. [Epub ahead of print]. 169. A. Bamias, U. Dafni, A. Karadimou, E. Timotheadou, G. Aravantinos, A. Psyrri, I. Xanthakis, M. Tsiatas, V. Koutoulidis, C. Constantinidis, C. Hatzimouratidis, E. Samantas, A. Visvikis, M. Chrisophos, K. Stravodimos, C. Deliveliotis, A. Eleftheraki, D. Pectasides, G. Fountzilas, M. A. Dimopoulos. Prospective, open-label, randomized, phase III study of two dose-dense regimens MVAC versus gemcitabine/ cisplatin in patients with inoperable, metastatic or relapsed urothelial cancer: a Hellenic Cooperative Oncology Group study (HE 16/03). Ann Oncol 2012 doi:10.1093/annonc/mds583. 170. Nikitas N, Karadimou A, Tsitoura E, Soupos N, Tsiatas M, Karavasilis V, Pectasides D, Pavlidis N, Chrisofos M, Adamakis I, Murray S, Fountzilas G, Dimopoulos MA, Bamias A. Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: a Hellenic Cooperative Oncology Group study. Pharmacogenomics. 2012;13:1595607. 171. Gavalas NG, Tsiatas M, Tsitsilonis O, Politi E, Ioannou K, Ziogas AC, Rodolakis A, Vlahos G, Thomakos N, Haidopoulos D, Terpos E, Antsaklis A, Dimopoulos MA, Bamias A. VEGF directly suppresses activation of T cells from ascites secondary to ovarian cancer via VEGF receptor type 2. Br J Cancer 2012;107:1869-75. 32 172. Cecere SC, Pisano C, Bamias A, Di Napoli M, Rossetti S, Facchini G, Tambaro R, Pignata S. Multidisciplinary Treatment of Early Stage Endometrial Cancer. Anticancer Agents Med Chem. 2012. 173. Zacharakis D, Thomakos N, Biliatis I, Rodolakis A, Simou M, Daskalakis G, Bamias A, Antsaklis A. Ultrasonographic markers and preoperative CA-125 to distinguish between borderline ovarian tumors and stage I ovarian cancer. Acta Obstet Gynecol Scand. 2012. doi: 10.1111/aogs.12046. 174. Bamias A, Bamia C, Zagouri F, Kostouros E, Kakoyianni K, Rodolakis A, Vlahos G, Haidopoulos D, Thomakos N, Antsaklis A, Dimopoulos MA. Improved Survival Trends in Platinum-Resistant Patients with Advanced Ovarian, Fallopian or Peritoneal Cancer Treated with First-Line Paclitaxel/Platinum Chemotherapy: The Impact of Novel Agents. Oncology. 2012;84(3):158-165. 175. Voutsas IF, Pistamaltzian N, Tsiatas ML, Skopeliti M, Katsila T, Mavrothalassiti I, Spyrou S, Dimopoulos MA, Tsitsilonis OE, Bamias A. Ovarian malignant ascites-derived lymphocytes stimulated with prothymosin α or its immunoactive decapeptide lyse autologous tumour cells in vitro and retard tumour growth in SCID mice. Eur J Cancer. 2012 doi:pii: S09598049(12)00956-2. 10.1016/j.ejca.2012.11.037. 176. Galsky MD, Krege S, Lin CC, Hahn N, Ecke TH, Moshier E, Sonpavde G, Godbold J, Oh WK, Bamias A. Cisplatin-based combination chemotherapy in septuagenarians with metastatic urothelial cancer. Urol Oncol. 2013. doi:pii: S1078-1439(12)00394-8. 10.1016/j.urolonc.2012.11.001. 177. Alexandra V. Stavropoulou, Florentia Fostira, Maroulio Pertesi, Marianthi Tsitlaidou, Gerassimos E. Voutsinas, Olga Triantafyllidou, Aristotelis Bamias, Meletios A. Dimopoulos, Eleni Timotheadou, Dimitrios Pectasides, Christos Christodoulou, George Klouvas, Christos Papadimitriou, Thomas Makatsoris, George Pentheroudakis, Gerasimos Aravantinos, Vassilis Karydakis, Drakoulis Yannoukakos, George Fountzilas, Irene Konstantopoulou. Prevalence of BRCA1 Mutations in Familial and Sporadic Greek Ovarian Cancer Cases. PloS ONE 2013; 8(3): e58182. doi:10.1371/journal.pone.0058182. 178. Maria Alevizaki, Elena Kyratzoglou, Aristoteles Bamias, Marinella Tzanela, Meletios A. Dimopoulos, Katerina Saltiki. Metachronous appearance of second malignancies in medullary thyroid carcinoma (MTC) patients: a diagnostic challenge and brief review of the literature. Endocrine 2013. 179. Lindsay Haines, Aristotle Bamias, Susan Krege, Chia-Chi Lin, Noah Hahn,Thorsten H. Ecke, Erin Moshier, Guru Sonpavde, James Godbold, William K. Oh, Matthew D. Galsky. The Impact of Gender on Outcomes in Patients With Metastatic Urothelial Carcinoma. Clinical Genitourinary Cancer 2013. 33 180. Matthew D. Galsky; Erin Moshier; Susan Krege; Chia-Chi Lin; Noah Hahn; Thorsten Ecke; Guru Sonpavde; James Godbold; William K. Oh; Aristotle Bamias. Nomogram for Predicting Survival in Patients With Unresectable and/or Metastatic Urothelial Cancer Who Are Treated With Cisplatin-Based Chemotherapy. Cancer 2013, doi: 10.1002/cncr.28146. 181. Matthew D. Galsky; Susan Krege; Chia-Chi Lin; Noah Hahn; Thorsten Ecke; Erin Moshier; Guru Sonpavde; James Godbold; William K. Oh; Aristotle Bamias. Relationship Between 6- and 9-Month Progression-Free Survival and Overall Survival in Patients With Metastatic Urothelial Cancer Treated With First-Line Cisplatin-Based Chemotherapy. Cancer 2013; doi: 10.1002/cncr.28145. 182. Bamias A, Tzannis K, Beuselinck B, Oudard S, Escudier B, Diosynopoulos D, Papazisis K, Lang H, Wolter P, de Guillebon E, Stravodimos K, Chrisofos M, Fountzilas G, Elaidi RT, Dimopoulos MA, Bamia C. Development and validation of a prognostic model in patients with metastatic renal cell carcinoma treated with sunitinib: a European collaboration. Br J Cancer. 2013; 109(2):332-41. doi: 10.1038/bjc.2013.341. 183. Nikos G. Gavalas, Michalis Liontos, Sofia-Paraskevi Trachana, Tina Bagratuni, Calliope Arapinis, Christine Liacos, Meletios A. Dimopoulos and Aristotle Bamias. Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer. Int. J. Mol. Sci. 2013, 14, 15885-15909; doi:10.3390/ijms140815885. 184. Nils Kroeger, Toni K. Choueiri, Jae-Lyn Lee, Georg A. Bjarnason, Jennifer J. Knox, Mary J. MacKenzie, Lori Wood, Sandy Srinivas, Ulka N. Vaishamayan, Sun-Young Rha, Sumanta K. Pal, Takeshi Yuasa, Frede Donskov, Neeraj Agarwal, Min-Han Tan, Aristotelis Bamis, Christian K. Kollmannsberger, Scott A. North, Brian I. Rini, Daniel Y.C. Heng. Survival Outcome and Treatment Response of Patients with Late Relapse from RenalCell Carcinoma in the Era of Targeted Therapy. Eur Urol 2013. http://dx.doi.org/10.1016/j.eururo.2013.07.031 34