University of Bradford
Institute of Cancer Therapeutics
Award and Teaching Institution:
Final Award:
Programme Title:
Duration:
Subject Benchmark statement:
Date Produced:
University of Bradford
MSc (QAA Framework for Higher Education Qualifications at
Level M)
Drug discovery
Fulltime (1 year)
Not applicable
31th March, 2008
Background
Based upon a greater understanding of the molecular aspects of disease progression, new
opportunities for chemical intervention in disease have emerged. Medicinal chemists provide the
expertise required in translating that understanding to the identification of suitable chemical
entities, and to the process of optimisation that ultimately leads to the discovery of new medicines.
This course is designed to provide you with a ‘state of the art’ education in modern drug
discovery, which meets the demand of employers in pharmaceutical industry. Opportunities to
learn the latest innovations in drug discovery, including computer-aided drug design and
techniques in parallel synthesis as well as electronic data management are provided in the
course. In addition, an extended project in drug discovery will not only provide you with a first
hand experience of the challenges in original research, but also gives you an opportunity to put in
practice the knowledge you have gained in drug discovery.
For career progression within this sector a postgraduate qualification is highly desirable. For
pursuit of this type of programme, you must have a degree qualification, usually in chemical or
biological sciences. The course promotes advanced scholarship within specialised areas
concomitant with the development of key transferable skills (in IT and bioinformatics) and
research techniques.
The course uses a range of teaching strategies to promote independent study and research; to
develop a systematic and critical understanding of the molecular basis of disease progression;
and to enhance autonomous learning and personal transferable skills. This course will facilitate
development of the skills you require for careers in academia, industry or for further research.
Enhancement of your independent learning skills during the course will equip you with the skills to
succeed as lifelong learners.
A.
Programme Aims
The programme is intended to:
A1
Enable you to develop a systematic understanding, critical awareness, and skills in
selected disciplines within the field of drug discovery.
A2
Provide you with a detailed knowledge of common strategies and methods for the
design and discovery of new medicines.
A3
Provide a strong knowledge base in the theory and practical skills of synthetic
organic chemistry and their application in drug discovery.
A4
Develop within the context of drug discovery, a comprehensive understanding of
communication, research skills and scientific method.
A5
Provide learning opportunities to enable you to think critically and to further
develop as an autonomous and lifelong learner.
A6
Further develop your ability in a range of personal and key skills.
B.
Programme Learning Outcomes
On successful completion of the programme you will be able to:
C.
B1
Subject Knowledge & Skills
B1.1 critically evaluate specialized areas of drug discovery.
B1.2 critically evaluate scientific literature and communicate scientific data.
B1.3 critically evaluate and appraise experimental laboratory techniques with
specific emphasis on those relevant for efficient preparation of pure organic
compounds.
B1.4 implement a research project, employ appropriate experimental approaches
and report your findings in relation to current knowledge and understanding.
B2
Core Academic Skills
B2.1 demonstrate critical thinking through an ability to independently:
 recognise, define and prioritise problems;
 analyse, interpret, objectively evaluate and prioritise information,
recognising its limitations;
B2.2 demonstrate a conceptual understanding of research and scientific method
through ability to independently:
 critically evaluate methodology;
 critically analyse and interpret data;
 formulate conclusions based on complete and incomplete data.
 critically evaluate strategies for experimental design and drug synthesis.
 critically analyze a therapeutic target and current therapeutic
approaches to that specific target.
B3
Personal & Key Skills
B3.1 Prepare and implement a programme of independent learning through
reflective study
B3.2 Apply skills in time-management, oral presentation, written communication
specifically by:
 writing and interpreting scientific reports.
 giving an oral scientific presentation.
The Curriculum
The Postgraduate Diploma is studied over two semesters, each comprising of 60 Credits
studied as double (20 Credit) or linked (10+10 Credits) modules. The programme is
designed as a core curriculum amounting to 40 Credits in semester 1 and 20 Credits in
semester 2. A further 20 Credits in semester 1 and 40 Credits in semester 2 are studied
from optional curriculum offered at ICT and other SoLS departments. The Masters
programme follows on from this and incorporates an additional 60 Credit research project.
D.
Teaching, Learning & Assessment Strategies
A wide variety of teaching methods appropriate to the learning outcomes of the individual
modules are employed throughout the programme, and are supported by Blackboard, the
virtual learning environment, provided by the University. A seminar program involving
external speakers with international reputations in the field will be established and you will
have the opportunity to discuss scientific issues with them. In addition, the Institute of
Cancer Therapeutics has regular internal research seminars and attendance at these is
encouraged. The teaching methods focus on student-centred approaches to learning. In
this way you will develop the attributes needed for life-long learning and continued
professional development. All students will be supported by a dedicated Course Tutor for
the duration of the course. Academic support is also provided by individual tutors /
supervisors for the Critical Appraisal and Research Project through regular meetings for
the duration of these activities.
Unit Code
CR-4016D
BM-9132L
CR-4014L
BM-9122D
CR-4001D
BM-9132L
CR-4014L
New
New
BM-9121D
BM-9131D
BM-9123D
CR-4015Z
Unit Title
Semester 1
Principles of Drug Discovery
Research & Analytical Methods
Critical Appraisal of a Current Topic in
Drug Discovery
Molecular and genetic basis of Disease I
Molecular Basis of Cancer and Cancer
Therapy
Semester 2
Research & Analytical Methods
Critical Appraisal of a Current Topic in
Drug Discovery
Chemical Toolbox for Drug Discovery
Case Studies in Drug Discovery
Toxicology and Oncology
Molecular Biology of the Cell
Molecular and genetic basis of Disease II
MSc
Research Project in Drug Discovery
Module Credits Level
Type
Sem
Core
Core
20
10
M
M
1
linked
Core
10
M
linked
Optional
Optional
20
20
M
M
1
1
Core
10
M
linked
Core
10
M
linked
Optional
Optional
Optional
Optional
Optional
20
20
20
20
20
M
M
M
M
M
2
2
2
2
2
60
M
N/A
The curriculum may change subject to the university course approval, monitoring and review
procedures.
Outcome B1.1 will be developed through a series of lectures, workshops and directed
study and assessed by unseen written examination questions, critical appraisal, and
course work assignments. Outcome B1.2 will be developed and assessed by critical
appraisal and course work. Acquisition of outcomes B1.3-1.5 will occur gradually and
cumulatively through a number of modules employing a mix of lectures, investigations,
workshops, individual project work and directed private study. They will be assessed by
an unseen written examination using constructed-response (essay) type questions, course
work, assignments, oral presentation, dissertation and project work.
Directed private study will involve you in a variety of activities, which include directed
reading of selected textbooks and specified source literature, Blackboard (directed Webbased materials), report writing and other assignments.
The development of outcomes B2.1 and B2.2 will be through involvement in small-group
seminars, laboratory investigations and individual project-based work and assessed by
critical appraisal, course work, seminar paper, written assignment, oral presentation and
project work. Key skills are embedded in the curriculum and some modules develop or
consolidate and assess one or more of the key skills listed in outcome B3.1 and B3.2.
More detailed description of the way that learning is related to assessment in the modules
that make up this programme can be found on the module descriptors.
E.
Admission requirements
Up to 30 students can be admitted to the Masters programme in Drug discovery, and this
may includes a significant number of applicants from outside the EU. Offers are made
following detailed consideration of each individual application. Most important in the
decision to offer a place is our assessment of a candidate’s potential to benefit from their
studies and of their ability to succeed on this particular course. Entrance requirements will
vary, but are set after consideration of each applicant’s academic background and
achievements and other relevant experience. As a general guideline, acceptance on the
Masters programme requires an Honours degree in chemical or biological sciences, or
related disciplines. The expectation is that this would be at 2.2 classification or above.
Applicants whose first language is not English will need to demonstrate proficiency in
English in accordance with University Regulations. For example, in the IELTS
(International English Language Testing Service test) you need to achieve an overall band
of at least 6 with 5 in each of the four sub-tests. In the TOEFL (Test of English as a
Foreign Language) administered by the Educational Testing Service, Princeton, New
Jersey, 08540, USA, you will need to score at least 550 on the paper-based test, 220 on
the computer-based test or 83 on the internet-based test. Students with prior learning or
prior experimental learning may be accredited on a case by case basis by a claim for APL
or APEL. For further details, see http://www.brad.ac.uk/international/english.php.
F.
Assessment regulations
To be eligible for the award of Postgraduate Diploma in Drug Discovery you must attain at
least 40% in individual units amounting to 100 Credits and at least 35% in individual units
amounting to the other 20 credits. To be eligible for the award of Masters in drug discovery
you must attain at least 40% in individual units amounting to 160 Credits (including a 60
Credit Research Project) at least 35% in individual units amounting to 20 credits. If you
obtain an overall weighted average of at least 70% at the first attempt, including a mark of
over 70% in the 60 Credit project at first attempt you will be awarded a Masters degree
with Distinction. If you obtain an overall weighted average of at least 60% at the first
attempt, including a mark of over 60% in the 60 Credit project at first attempt will be
awarded a Masters degree with Merit. The full assessment regulations covering
postgraduate courses are available on the University website.
G.
Student Support & Guidance
The Institute of Cancer Therapeutics will integrate the established practices of the
Department of Biomedical Sciences that has a good reputation in this area. Students on
the Masters programme will be supported by both a dedicated Course Tutor (through
fortnightly meetings with the cohort of students) and allocated individual personal tutorial
support. Regular Staff Student Liaison meetings inform the course team of student views
and Academic Committee meetings have student representation. Student academic
support also is provided by individual tutors / supervisors for the Critical Appraisal and
Research Project through regular meetings for the duration of these activities. Formalised
formative feedback is given on drafts of these elements prior to submission. Departmental
support is enhanced by University Learning Support Services that includes Library and
Computing services, a Careers Service and a Disabilities Office.
H.
Further Information
Further information can be obtained from the Postgraduate Admissions Tutor, Institute of
Cancer Therapeutics, University of Bradford.
Please note that the above information is subject to change.
Descriptions of Modules
Module Title: Principles of Drug discovery
Module Type: Standard module
Module Code:
To be confirmed
Module Credit: 20
Provider: Institute of Cancer Therapeutics
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinator: Dr. R. A. Falconer
Additional Tutors: Prof Laurence Patterson, Dr. R. A. Falconer, Dr. K. Pors
Teaching Period: Semester 1
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
Corequisite(s):
None
Aims:
To provide students with an appreciation and understanding of the various stages in drug
discovery process. To provide students with a current and critical evaluation of methods,
techniques and strategies used to select molecules for evaluation of their biological properties. In
particular, a specific aim is to provide students with an understanding of the criteria used for
“drugable” targets.
Learning, Teaching and Assessment Strategy:
Course material is delivered through a combination of lectures, workshops, and student directed
learning. The assessment is through a closed book final examination and coursework
assessment.
Study Hours:
Lectures:
Seminars/Tutorials:
Laboratory/Practical:
Total:
24.00
4.00
0.00
200.00
Directed Study:
Other:
Formal Exams:
170.00
0.00
2.00
Learning Outcomes: On completion of the module you will be able to:
1. Knowledge & Understanding
Appraise the drug discovery process in particular strategies and tools for identification and
optimisation of leads; importance, strategies and tools for PKPD profiling and other pre-clinical
issues, clinical trials, issues related to large scale drug production, intellectual property issues and
regulatory affairs.
2. Subject-Specific Skills:
Critically evaluate issues that are relevant in a drug discovery process.
3. Personal Transferable Skills
Employ generic literature skills for life-long learning (literature & databases).
Mode of Assessment:
1.
Assessment Type
Duration
Examination - closed book 2.00 hours
Description
Students must answer five out of seven questions.
Percentage
70%
2.
Assessment Type
Duration
Percentage
Coursework
30%
Description
Assessment through worked problem sheets in four tutorial sessions (7.5% for each).
Supplementary Assessment:
As Above
Outline Syllabus:
An overview of the drug discovery process: Sources of leads; lead identification strategies; lead
optimisation strategies including diversity oriented synthesis, in vitro and in vivo testing; PKPD
and other pre-clinical issues, clinical trials, issues related to large scale drug production,
intellectual property issues and regulatory affairs.
An introduction to drug discovery: relationship between physical properties and biological activity,
Structural features and pharmacological activity, Drug targets: enzymes and enzyme inhibition,
types and examples of enzymes, receptors and agonist/antagonist activity, types and examples of
receptors.
Version No: 1
Reading List:
Module Title: Research and Analytical Methods
Module Type: Linked 10+10
Module Code:
BM-9132L
Module Credit: 20
Provider: Biomedical Sciences
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinator: Dr. S M. Picksley
Additional Tutors:
Teaching Period: Semesters 1 and 2
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
To provide a comprehensive understanding of selected important advanced biomedical
techniques; to develop student autonomy in learning and to develop research skills as well as
enhance written communication skills
Learning, Teaching and Assessment Strategy:
This course will be presented as a series of lectures, tutorials, workshops and laboratory
sessions. Students will be responsible for their logbook of activities.
Study Hours:
Lectures:
Seminars/Tutorials:
Laboratory/Practical:
Total:
22.00
3.00
24.00
200.00
Directed Study:
Other:
Formal Exams:
135.00
16.00
0.00
Learning Outcomes: On completion of the module you will be able to demonstrate:
1. Knowledge & Understanding
Critically evaluate advanced biomedical techniques and their application in the laboratory;
autonomously design experiments and carry out good laboratory practice to a professional
standard.
2. Subject-Specific Skills
Develop a knowledge and practical experience of electron microscopy, cell culture and molecular
biology, particularly gene cloning and PCR. Evaluate health and safety considerations required
legally for experimentation.
3. Personal Transferable Skills
Apply practical experience of data handling and statistics, and experience useful to lifelong
learning by production of a portfolio of work.
Mode of Assessment:
1.
2.
Assessment Type
Duration
Coursework
Description
Production of a portfolio of work
Assessment Type
Duration
Attendance requirement
Description
Attendance requirement
Percentage
90%
Percentage
10%
Supplementary Assessment:
As above
Outline Syllabus:
Advanced biomedical techniques: Introduction to biomedical analysis, Good laboratory and
clinical practice. Sample preparation for bio analysis. Analytical biochemical techniques:
separation methods, GLC, HPLC, FPLC chromatography (ion, gel, affinity), electrophoresis, mass
spectrometry. Methods to study cells: microscopy, cell culture, cell proliferation, identification of
cell markers & cell purification by FACS. Recombinant DNA techniques: Concepts of gene cloning
and its impact on research and biotechnology. DNA techniques; isolation of DNA, DNA modifying
enzymes, Polymerise Chain Reaction (PCR),Northern & Southern blotting, molecular analysis of
gene expression (proteomics & transgenic approaches). Attendance at guest seminars and
production of summary of topic.
Version No: 2
Reading List:
Module Title: Critical Appraisal of a Current Topic in Drug Discovery
Module Type: linked 10+10
Module Code: To be confirmed
Module Credit: 20
Provider: Institute of Cancer Therapeutics
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinator: Dr. K. Afarinkia
Additional Tutors:
Teaching Period: Semesters 1 and 2
Academic Year: 2008/9
Module Occurrence: A
Level: M (Postgraduate Masters)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
Develop a critical awareness and a comprehensive understanding of research being undertaken
by other scientists in a specific topic. Provide students with an opportunity to autonomously plan,
undertake and report, orally and in writing, at the forefront of biomedical sciences.
Learning Teaching and Assessment Strategy:
Each student will choose a topic of interest from an extended list by the end of Semester 1, then
plan, undertake and report on this topic. An academic member of staff will act as a supervisor for
their topic providing guidance and advice on the research area. A draft of the essay will be
produced after two weeks in Semester 2 for feedback to be available for incorporation into the
final essay at the end of semester 2.
Study Hours:
Lectures:
Seminars/Tutorials:
Laboratory/Practical:
Total:
0.00
15.00
0.00
200.00
Directed Study:
Other:
Formal Exams:
185.00
0.00
0.00
Learning Outcomes: On completion of the module the student will be able to demonstrate:
1. Knowledge & Understanding
Plan and implement autonomously a critical appraisal of a selected area of previously reported
research.
2. Subject-Specific Skills
Present a seminar on the topic; attend seminars presented by other students and contribute in the
form of questions and discussion; produce an extended essay/report.
3. Personal Transferable Skills
Organise and manage an extensive literature search at the forefront of knowledge. Develop and
evaluate a strategy to communicate in writing and orally your critical appraisal. Review and revise
approaches to monitor and critically reflect on progress, to implement a plan for the critical
appraisal report. Employ time management through planning the work and meeting deadlines.
Work co-operatively with a supervisor to plan work, agree objectives and responsibilities.
Contribute to discussions on presentations by peer reviewing other students’ presentations.
Mode of Assessment:
1.
Assessment Type
Duration
Coursework
Description
A critical essay of up to 5,000 words
Percentage
80%
2.
Assessment Type
Coursework
Description
A seminar of the topic
Percentage
20%
Duration
Supplementary Assessment:
As above
Outline Syllabus:
The syllabus will be determined by the content of the topic that is chosen by the student and will
therefore be individual to the student.
Version No: 1
Module Title: Molecular and Genetic Basis of Disease I
Module Type: Standard module
Module Code:
BM-9122D
Module Credit: 20
Provider: Biomedical Sciences
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinator: Dr S M Picksley
Additional Tutors: Dr S Jones, Dr R M Phillips, Dr M J Thornton
Teaching Period: Semester 1
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
Corequisite(s):
None
Aims:
To develop a systematic and critically evaluative understanding of the molecular and genetic
basis of selected important diseases such as cancer (importance of tumour suppressors,
oncogenes, DNA repair and cell cycle proteins, cellular responses to hypoxia), disorders of steroid
metabolism and synthesis, Parkinson's disease and cystic fibrosis. Develop critical understanding
of research methodologies, data handling, and interpretation in selected fields of medical
biochemistry; develop specialised practical skills.
Learning, Teaching and Assessment Strategy:
A combination of lectures, student-led seminars on key research papers, and an essay and
laboratory investigations.
Study Hours:
Lectures:
19.00
Directed Study:
138.00
Seminars/Tutorials:
12.00
Other:
12.00
Laboratory/Practical:
16.00
Formal Exams:
3.00
Total:
200.00
Learning Outcomes: On completion of the module the student will be able to :
1. Knowledge & Understanding
Critically evaluate the genetic and biochemical aspects of selected human diseases and
experimental approaches for their study
2. Subject-Specific Skills
Critically evaluate the current research literature & state-of-the-art reviews; be able to work in a
team to design valid experiments & to critically evaluate & interpret results from such experiments
in medical biochemistry; be able to utilise biochemical data to evaluate clinical situations.
3. Personal Transferable Skills
Carryout multistage calculations and evaluate their overall strategy in a group. Explore problems,
compare and review approaches to solve them. Develop a strategy to present a discussion of a
research paper with peers. Write essays and a laboratory report.
Mode of Assessment:
1.
Assessment Type
Duration
Percentage
Examination - closed book 3.00 hours
50%
Description
One 3-hour examination (two essays to be answered from a choice of five)
2.
Assessment Type
Duration
Percentage
Coursework
50%
Description
Two short laboratory reports, oral presentation/analysis of a research paper and an essay
Supplementary Assessment:
As above
Outline Syllabus:
Biochemical and functinal aspects of steriods, detailed structure and function, mechanism of
action and role in cancer and wound healing. The biochemistry of cancer including the role of cell
cycle proteins in development of cancer. Importance of DNA repair and properties and functions
of the p53 tumour suppressor in regulation of apoptosis, the cell cycle and ageing. Origins and
significance of hypoxia, cellular adaptation to hypoxia, therapeutic approaches to hypoxia.
Biochemical and molecular basis of Parkinson's disease, and cystic fibrosis.
Version No: 5
Reading List:
Module Title: Molecular Basis of Cancer and Cancer Therapy
Module Type: Standard module
Module Code:
CR-4001D
Module Credit: 20
Provider: Institute of Cancer Therapeutics
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinator: Dr. R. M. Phillips
Additional Tutors:
Teaching Period: Semester 1
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
To develop a systematic and critical understanding of the hallmarks of cancer, their implications
for cancer treatment and opportunities for therapeutic intervention. The molecular biology of
cancer will illustrate the identification of potential targets for therapeutic intervention and the
importance of tumour pathology current and future treatment strategies.
Learning, Teaching and Assessment Strategy:
A combination of lectures, invited seminar speakers, student-led seminars and laboratory
investigation, plus student directed learning. The student led seminars will consist of a journal club
exercise where students will individually review and present a selected research paper. The
independent work will be to prepare a detailed profile of a specific biochemical or molecular target
that is of current interest in terms of therapeutic intervention.
Study Hours:
Lectures:
Seminars/Tutorials:
Laboratory/Practical:
Total:
24.00
6.00
4.00
200.00
Directed Study:
Other:
Formal Exams:
163.00
0.00
3.00
Learning Outcomes: On completion of the module you will be able to demonstrate:
1. Knowledge & Understanding
Critically evaluate the molecular basis of cancer, its classification, current treatment approaches
for cancer and the concept of target identification and validation as applied to anti-cancer drug
discovery.
2. Subject-Specific Skills
Criticallly evalulate and interpret the current research literature & state of the reviews; be able to
interpret routine histological samples to analyse human tumour classification and examples of
xenographs.
3. Personal Transferable Skills
Develop a strategy to present a discussion of a research paper (journal club); collate and
summarise target evaluation for a defined report style. Undertake analysis of the human genome
database. Develop generic literature skills for life-long learning (literature & databases).
Mode of Assessment:
1.
Assessment Type
Duration
Percentage
Examination - closed book 3.00 hours
50%
Description
Three hour examination - two essays from a choice of five
2.
Assessment Type
Duration
Coursework
Description
Molecular Target Profile Report 3000 words
Percentage
20%
3.
Assessment Type
Duration
Coursework
Description
Practical Histology Spot Test
Percentage
15%
4.
Assessment Type
Duration
Coursework
Description
Oral presentation (journal club)
Percentage
15%
Supplementary Assessment:
As above
Outline Syllabus:
There are two major themes within this module. The first is designed to inform students of current
practise in Oncology and will focus on the classification of tumours, pathological parameters used
to determine therapeutic intervention strategies and the classical chemotherapeutic drugs. The
later will focus on the classification of current drugs, their mechanism of action and the problems
associated with current drugs (i.e. toxicity, multi-drug resistance etc). It is widely acknowledged
that new therapeutics are required and that tumour biology represents the driving force behind the
development of new therapeutics. In order to understand these new approaches, the cancer
pharmacologist must have a good understanding of the molecular and genetic/epigenetic basis of
cancer and this therefore forms the basis of the second major theme in this module. This section
will cover the 'hallmarks of cancer' in terms of self sufficiency in growth signals, evading
apoptosis, insensitivity to anti-growth signals, sustained angiogenesis, tissue invasion and
metastasis, unlimited replicative potential and genetic instability. The emphasis throughout will be
placed on the differences that exist between tumour and normal cells as these represent a key
step in developing novel therapeutics. Students will develop their ability to work in small groups
during laboratory work. They will extend their literature searching, presentation and report writing
skills in preparing a journal club, and molecular target profile report.
Version No: 1
Reading List:
Module Title: Chemical Toolbox for Drug Discovery
Module Type: Standard module
Module Code:
To be confirmed
Module Credit: 20
Provider: Institute of Cancer Therapeutics
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinator: Dr. K. Afarinkia
Additional Tutors: Dr. K. Afarinkia, Dr. K. Pors, Dr. R. A. Falconer
Teaching Period: Semester 1
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
To provide students with a current and critical evaluation of methods, techniques and strategies
used to prepare molecules for evaluation of their biological properties. In particular, a specific aim
is to provide students with an understanding of the reagents and conditions used for selective
molecular transformations.
Learning, Teaching and Assessment Strategy:
Course material is delivered through a combination of lectures, workshops, and student directed
learning. The assessment is a combination of closed book final examination and coursework
assessment through worked problem sheets in four tutorial sessions.
Study Hours:
Lectures:
Seminars/Tutorials:
Laboratory/Practical:
Total:
24.00
4.00
0.00
200.00
Directed Study:
Other:
Formal Exams:
170.00
0.00
2.00
Learning Outcomes: On completion of the module the student will be able to demonstrate:
1. Knowledge & Understanding
Critically evaluate, in the context which are relevant to drug discovery such as diversity oriented
synthesis, strategies and methods for multistep construction of organic molecules.
2. Subject-Specific Skills
Learn about common and generally used chemical reagent, as well as practical means of
obtaining organic molecules that are relevant in drug discovery.
3. Personal Transferable Skills
Employ generic literature skills for life-long learning (literature & databases).
Mode of Assessment:
1.
Assessment Type
Duration
Examination - closed book 2.00 hours
Description
Students must answer four out of six questions.
Percentage
70%
2.
Assessment Type
Duration
Percentage
Coursework
30%
Description
Assessment through worked problem sheets in four tutorial/workshop sessions (7.5% for
each)
Supplementary Assessment:
As above.
Outline Syllabus:
Topics to be covered include; Survey of methods for the synthesis of organic molecules,
Functional group interconversion, selective molecular transformations, protection/deprotection
strategies, simple carbocyclic and heterocyclic synthesis, strategies for diversity oriented
synthesis. Principles of asymmetric synthesis. Emphasis will be placed upon a practical means of
obtaining organic molecules that are relevant in drug discovery, rather than a general revision of
the methods. Therefore, many examples of synthesis of pharmaceutics will be presented.
Version No: 1
Reading List:
Module Title: Case Studies in Drug discovery
Module Type: Standard module
Module Code:
To be confirmed
Module Credit: 20
Provider: Institute of Cancer Therapeutics
Related Department / Subject Area:
Principal Co-Ordinator: Dr. K. Pors
Additional Tutors: Dr. K. Afarinkia, Dr. R. A. Falconer, Dr. K. Pors, Prof L. H. Patterson
Teaching Period: Semester 2
Academic Year: 2008/9
Module Occurrence: A
Level: M (Postgraduate Masters)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
To provide a comprehensive understanding of the background and current issue in research into
an area of drug discovery or drug discovery. To broaden student’s appreciation of the wide range
of research in drug discovery.
Learning Teaching and Assessment Strategy:
This course will be presented as a series of lectures and through attendance in departmental
seminars throughout the semester.
Study Hours:
Lectures:
Seminars/Tutorials:
Laboratory/Practical:
Total:
24.00
6.00
0.00
200.00
Directed Study:
Other:
Formal Exams:
130.00
38.00
2.00
Learning Outcomes: On completion of the module the student will be able to demonstrate:
1. Knowledge & Understanding
Evaluate the current state-of-play and future directions in selected areas of medicinal chemistry
and drug discovery.
2. Subject-Specific Skills
Identify the logical approaches taken to maximise the potency and efficacy of new drugs in
preclinical setting and the strategies undertaken to identify best clinical candidates based on
PKPD profiles.
3. Personal Transferable Skills
Develop a strategy to present and discuss a piece of research both in a written and oral report.
Develop an IT strategy to organise their literature research. Demonstrate time management. Work
with a supervisor to plan, agree objectives, responsibilities and working arrangements. Review
work and identify ways of improving future work. Explore problems and compare and select
options to overcome them.
Mode of Assessment:
1.
Assessment Type
Duration
Percentage
Written exam
2 hours
60%
Description
Students are required to answer four out of eight questions on a 2 hour closed book exam.
2.
Assessment Type
Duration
Coursework
Description
A drug discovery report (up to 1500 words).
Percentage
40%
Supplementary Assessment:
As above.
Outline Syllabus:
An overview of the discovery and development process for four specific medicines currently on
the market or soon to be introduced. Topics will include new medicines for cancer therapy, antiinfectives, antidiabetes, cardiovascular, respiratory, and CNS disorders.
Version No: 1
Module Title: Toxicology and Oncology
Module Type: Standard
Module Code: BM-9121D
Module Credit: 20
Provider: Biomedical Sciences
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinators: Dr RM Phillips
Additional Tutors:
Teaching Period: Second semester
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
To develop a systematic and critical evaluativon of knowledge and understanding of the molecular
and cellular abnormalities resulting in cancer & toxicology, which lead to system abnormalities;
critically evaluate modern methods used to control these disorders.
Learning Teaching & Assessment Strategy:
A combination of lectures, workshops, student-led seminars and laboratory investigation.
Autonomous student learning will be encouraged by provision of an essay topic for independent
research, anda critical evaluation of a research paper, which will be presented to their peer group,
and production of a practical report.
Study Hours:
Lectures:
23.00
Seminars/Tutorials:
10.00
Laboratory/Practical: 12.00
Total:
200.00
Directed Study:
Other:
Formal Exams:
133.00
9.00
3.00
Learning Outcomes: On completion of the module you will be able to:
1. Knowledge & Understanding
Critically appraise the molecular & cellular basis of cancer as far as current knowledge permits;
recognise the modern methods used to control cancer and evaluate them. Evaluate symptoms
caused by toxic agents and their effects in causing human disease.
2. Subject-Specific Skills
Perform and evaluate practical skills involved in the study of cancer. Critically evaluate and
interpret a key research paper and a key topic.
3. Personal Transferable Skills
Evaluate autonomously a key topic and a research paper and develop a strategy to communicate
them in writing and orally, respectively. Write an essay and a research report. Demonstrate time
management. Contribute to presentations in workshops.
Mode of Assessment:
1.
Assessment Type
Duration
Percentage
Examination
3.00 hours
50%
Description
One 3-hour examination (two essays to be answered from a choice of five)
2.
Assessment Type
Duration
Percentage
Coursework
50%
Description
Coursework incl laboratory report/essay/oral presentation on research paper
Supplementary Assessment:
As above
Outline Syllabus:
Toxicology would cover ionising radiation (eg Chernobyl problem) and non-ionising radiation (eg
UV light) and their potential roles in induction of cancers and birth defects. Industrial pollution and
disease; the biomethylation of metals and metallloids and toxicology of organometallics (eg
mercury, lead). Chlorinated hydrocarbons and environmental health including oestrogen like
factors, PCBs, herbicides and pesticides. B napthylamine and bladder cancer, asbsestos in
induction of asbestosis and mesothelioma. Microbial toxins and disease. Oncology section would
cover carcinogenesis and pre-neoplasia, the relationship between genes and cancer; oncogenes,
proto-oncogenes, and tumour suppresser genes, classification and differentiation of tumours,
invasion and metastasis. Cancer epidemiology. Methods of cancer control: -therapy and
management of clinical disease, including endocrine tumours, cancer chemotherapy and the
toxicity of anticancer drugs cytotoxicity assays. Students will develop their ability to work in pairs
and small groups during laboratory work and a workshop session. They will extend their literature
search, presentation and abstracting skills in preparing individual seminars with word-processed
written summaries and their report skills in preparing written laboratory reports.
Version No: 3
Module Title: Molecular Biology of the Cell
Module Type: Standard
Module Code: BM-9131D
Module Credit: 20
Provider: Biomedical Sciences
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinators: Dr S Picksley
Additional Tutors:
Teaching Period: Second semester
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
To extend and apply knowledge and understanding of molecular genetics, molecular cell biology
and recombinant DNA technology.
Learning Teaching & Assessment Strategy:
Lectures, seminars, tutorials, workshops and laboratory classes.
Study Hours:
Lectures:
42.00
Seminars/Tutorials:
7.00
Laboratory/Practical: 15.00
Total:
200.00
Directed Study:
Other:
Formal Exams:
133.00
0.00
3.00
Learning Outcomes: On completion of the module you will be able to:
1. Knowledge & Understanding
Ability to explain and critically discuss the molecular basis of cell structure and function,
phenotype and genotype.
2. Subject-Specific Skills
A critical appreciation of the knowledge and techniques used to clone a human gene.
3. Personal Transferable Skills
Problem solving, manipulation of DNA sequences, I.T skills in bio informatics.
Mode of Assessment:
1.
Assessment Type
Duration
Coursework
Description
Written essay of 3000 words
Percentage
100%
Supplementary Assessment:
As above
Outline Syllabus:
MOLECULAR GENETICS The bacterial genome and gene expression, DNA replication and
fidelity of replication in bacteria. Autogenesis, gene exchange between bacteria, the eukaryotic
genome and gene expression, control of gene expression in prokaryotic and eukaryotic systems.
RECOMBINANT DNA TECHNOLOGY Concepts of gene cloning and its impact on research and
biotechnology. INTRODUCTION TO DNA manipulation techniques: cloning vehicles, gene
libraries, DNA sequencing, DNA fingerprinting for the forensic laboratory. MOLECULAR CELL
BIOLOGY Molecular nature of cellular responses, principles of signalling molecules and their
receptors: receptors; cell-cell recognition/adhesion; general principles of intracellular signalling
cascades. Protein structure/function relationships. LABORATORY WORK: To reinforce aspects of
theory which relate to bacterial molecular genetics and recombinant DNA technology.
Version No: 2
Module Title: Molecular and Genetic Basis of Disease II
Module Type: Standard
Module Code: BM-9123D
Module Credit: 20
Provider: Biomedical Sciences
Related Department / Subject Area: Biomedical Sciences
Principal Co-Ordinators: Dr AM Graham
Additional Tutors: Dr KM Naseem
Teaching Period: Second semester
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
None
Corequisite(s):
None
Aims:
To gain a systemic knowledge/critical understanding of physiological & clinical biochemistry by
detailed reference to selected topics relevant to cardiovascular disease; develop critical
appreciation of research methodologies through student led analysis of research papers, data
handling & interpretation in selected fields of biochemistry.
Learning Teaching & Assessment Strategy: A combination of lectures, data analysis exercises
and student-led seminars on research papers and laboratory investigation.
Study Hours:
Lectures:
19.00
Seminars/Tutorials:
9.00
Laboratory/Practical: 12.00
Total:
200.00
Directed Study:
Other:
Formal Exams:
157.00
0.00
3.00
Learning Outcomes: On completion of the module you will be able to:
1. Knowledge & Understanding
Critically evaluate biochemistry by studying the biochemical basis of metabolic and vascular
diseases. Critically evaluate experimental approaches to study of selected metabolic and vascular
diseases.
2. Subject-Specific Skills
Gain experience in the use of current research and state-of-the-art reviews; be able to work in a
team to design valid experiments and to critically evaluate/interpret results from such experiments
in medical biochemistry; be able to utilise biochemical knowledge to evaluate clinical situations.
3. Personal Transferable Skills
Explore problems, compare and review approaches to solve them. Develop a strategy to present
a discussion of a research paper with peers. Write essays and a laboratory report.
Mode of Assessment:
1.
Assessment Type
Duration
Percentage
Examination
3.00 hours
50%
Description
One 3-hour examination (two essays to be answered from a choice of five)
2.
Assessment Type
Duration
Percentage
Coursework
50%
Description
1. Practical; 2. Assessed problem solving exercise; 3. Student led presentation of a
research paper. All equally weight
Supplementary Assessment:
As above
Outline Syllabus:
The biochemistry of diabetes mellitus; forms of diabetes; treatment of diabetes; molecular aspects
of glucose transport. Medical Aspects of lipid and lipoprotein nmetabolism; hyperlipidaemias;
cholesterol metabolism, LDL receptor and familial hypercholesterolaemia. Reactive oxygen
species, antioxidant mechanisms; lipid peroxidation and importance/roles of oxidised LDL.
Biochemistry of vascular disease; atherosclerosis and thrombosis and their treatments;
Hypertension; Biochemical regulation of blood pressure, risk factors for hypertension; Gene
therapy in vascular disease. Biochemical mechanisms of angiogenesis and importance in
development and disease.
Version No: 3
Module Title: Research Project in Drug discovery
Module Type: Project
Module Code: To be confirmed
Module Credit: 60
Provider: Biomedical Sciences & Institute of Cancer Therapeutics
Related Department / Subject Area:
Principal Co-Ordinators: Dr K. Afarinkia
Additional Tutors:
Teaching Period: Dissertation
Academic Year: 2008/9
Module Occurrence: A
Level: M (Post-graduate)
Prerequisite(s):
Critical Appraisal of a Current Topic in Drug Discovery
Corequisite(s):
None
Aims:
Carry out original research in an area of drug discovery. Develop self-direction and originality in
the application of knowledge and problem solving. Gain an awareness of key issues in the drug
discovery process. Develop comprehensive understanding of appropriate laboratory techniques
and how those techniques can be used to create and interpret knowledge. Further develop
analytical, critical, and IT skills in the presentation of a practical research report.
Learning Teaching & Assessment Strategy:
Each student has extensive choice allowing a topic of interest to be researched. Following
background reading from the scientific literature an extended research project is carried out over
12 weeks under supervision of a member of academic staff. Students are responsible for the
legislative aspects of the projects (COSHH assessment etc.). The unit develops and enhances
student autonomy in learning.
Study Hours:
Lectures:
6.00
Seminars/Tutorials: 12.00
Laboratory/Practical: 385.00
Total:
600.00
Directed Study:
Other:
Formal Exams:
120.00
77.00
0.00
Learning Outcomes: On completion of the module you will be able to:
1. Knowledge & Understanding
Research and analyse a current problem in drug discovery and drug development.
2. Subject-Specific Skills
Develop literature skills using electronic media sources; critically assess previously reported
research; plan & implement programme of original research; appraise a particular scientific
problem; analyse & present data in appropriate way; interpret results & discuss critically in context
of published work; originally apply knowledge in a specific area. Carry out appropriate COSHH
assessment of work undertaken during the project.
3. Personal Transferable Skills
Develop a strategy to present and discuss their research in a research report and during viva
voce. Develop an IT strategy to organise their literature research. Employ time management.
Work with a supervisor to plan, agree objectives, responsibilities and working arrangements.
Review work and identify ways of improving future work. Explore problems and compare and
select options to overcome them.
Mode of Assessment:
1.
Assessment Type
Duration
Percentage
Viva voce
40%
Description
A defence of the findings and conclusions of the research.
2.
Assessment Type
Duration
Percentage
Research report
50%
Description
12,000 word project report of the background, experimental methods and results of the
research.
3.
Assessment type
Duration
Percentage
Oral presentation
10%
Description A talk comprising a 20 minute presentation of the background, methods and
results of the research, and 10 minutes answers on the questions related to the above.
Supplementary Assessment:
As Original
Outline Syllabus:
As agreed with the project supervisor.
Version No: 1