Supplementary Materials TABLE II. No. Class Protein Proteins with three-state kinetics 1 / Tryptophan synthase β2-subunit 2 / C-terminal domain from PGKy, domain: 177394 3 / Tryptophan synthase α-subunitz 4 / Ribonuclease HIv 5 / GroEL apical domain 6 / CheY 7 All- Apomyoglobinu 8 All- CRBP II 9 All- ILBPt 10 + Lysozyme (hen rgg white) 11 All- CD2, 1st domain 12 / N-terminal domain from PGK, domain: 1176 13 + Barnase 14 / Barstar 15 + P16 protein 16 All- IFABP from rat 17 All- Cro protein 18 All- Twitchin Ig repeat 27 19 + Suc1s 20 + HypF-N 21 All- Colicin E7 immunity protein Proteins with two-state kinetics 22 + Muscle-AcP 23 All- AH3-domain (PI3 kinase) 24 All- Fibronectin 9th FN3 module, domain: 11421235 25 All- Twitchin 26 + Common-type Acp 27 All- Tenascin (short form) 28 All- PsaE 29 + FKBP12 30 All- SH3 domain 31 + His-containing phosphocarrier protein 32 + Ci2 33 All- SH3 domain (src) 34 + IgG-binding domain of streptococcal protein L 35 All- Tendamistat 36 All- SH3-domain (fyn) 37 All- CspA List of Proteins. PDB L L L Lloop lnkf Ref. 1QOP_B 396 229 82 85 -6.91 1 1PHP 390 220 64 106 -3.45 2 1QOP_A 268 162 39 67 -2.53 3 2RN2 1JON 3CHY 1A6N 1OPA 1EAL 1HEL 1HNG 1PHP 165 155 128 151 135 127 129 176 176 75 60 71 136 32 24 90 27 95 30 43 23 0 73 67 14 91 28 60 52 34 15 30 36 25 58 53 0.69 0.83 0.92 1.15 1.38 1.38 1.39 1.84 2.30 4 5 6 7 8 9 10,11 12 11 1BNI 1BTA 2A5E 1IFC 2CRO 1TIT 1SCE 1GXT 1CEI 110 89 156 89 71 98 112 91 87 40 53 93 51 49 4 36 24 59 24 16 2 16 0 34 10 35 2 46 20 61 22 22 60 66 32 26 2.53 3.43 3.45 3.45 3.68 3.68 4.14 4.37 5.76 13 14 15 8 16 17 18 19 20 1APS 1PNJ 1FNF 98 86 94 27 16 9 35 26 44 36 44 41 -1.48 -1.15 -0.92 21 22 23 1WIT 2ACY 1TEN 1PSE 1FKB 1AEY 1POH 93 98 90 69 107 62 85 20 33 9 11 37 9 43 53 38 47 19 42 28 23 20 27 34 39 28 25 19 0.46 0.92 1.06 1.17 1.46 2.09 2.76 24 25 26 27 28 29,30 31 2CI2 1SRL 2PTL 83 64 78 24 4 18 20 20 20 39 40 40 3.91 4.04 4.10 32 33 34 2AIT 1NYF 1MJC 74 67 69 2 5 14 32 26 32 40 36 23 4.20 4.54 5.24 35 36 37 38 39 + + Protein G Spliceosomal protein U1A 40 + S6 41 All- CspB (Thermotoga maritima) 42 All- ACBP 43 + N-terminal domain from L9, domain: 155 44 + Activation domain procarboxypeptidase A2, domain: 581 45 All- Sso7d 46 All- CspB (Bacillus subtilis) 47 All- Colicin E9 immunity protein 48 + Ubiquitin 49 All- l repressor 50 All- Cytochrome c (horse) 51 All- Arc repressor 52 All- Cytochrome c (yeast) 53 All- E3/E1 binding domain of dihydrolipoyl acyltransferase 54 All- Villin headpiece 55 All- Engrailed homeodomain 56 All- B-domain of staphylococcal protein A 57 All- Cytochrome b562 58 DPa Trp-cage 59 DPa α-helix (short peptide of 21-residues) a designed protein 1PGB 1URN_A 56 97 20 45 24 23 12 29 5.66 5.76 38 39 1RIS 1G6P 101 66 41 6 39 30 21 30 5.99 6.22 40-42 43 2ABD 1DIV 86 55 63 31 0 13 23 11 6.55 6.61 44 45 1AYE 76 38 19 19 6.79 46 1BNZ 1CSP 1IMQ 64 67 86 22 11 57 33 35 0 9 21 29 6.95 6.98 7.28 27 43,47 20 76 92 105 53 108 43 30 73 59 36 61 26 26 0 2 0 2 0 20 19 44 17 45 17 7.33 8.50 8.76 9.27 9.62 9.67 48 49 50 51 50 52 1VII 1ENH 1BDD 36 54 60 25 40 45 0 0 0 11 14 15 11.51 11.59 11.74 53 54 55 256B 1L2Y 106 20 21 96 12 21 0 0 0 10 8 0 12.20 12.43 15.43 56 57 58 1UBQ 1LMB_3 1HRC 1ARR 1YCC 2PDD 1. 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