Supplementary Tables 5a-c Details on statistical analysis
Survival and the association with (cyto)genetic aberrations was analyzed for the present cohort of
patients with CLL and MYC-translocations. Additionally, the same analysis was performed for a cohort of
patients with CLL and BCL2-translocations [described in Supplementary Table 1a and by Put et al. (1)]
(not shown in the manuscript).
Supplementary Table 5a 5-year survival
5y survival
Group
Time
Number
Events
Survival SE
Lower
(months)
at risk
(number)
95% CI
MYC
5y OS clinical
60
8
9
0.566
0.115
0.381
BCL2
5y OS clinical
60
24
3
0.899
0.055
0.798
MYC
5y OS genetic
60
2
12
0.304
0.129
0.133
BCL2
5y OS genetic
60
11
7
0.732
0.090
0.575
MYC
5y TTT clinical
60
3
25
0.089
0.058
0.025
BCL2
5y TTT clinical
60
11
18
0.452
0.091
0.305
5y, 5-year; OS, overall survival; TTT, time to treatment; clinical, from clinical diagnosis; genetic, from genetic
detection; SE, standard error; CI, confidence interval; n, number; NA, not available;
Upper
95% CI
0.841
1.000
0.698
0.931
0.315
0.670
Supplementary Table 5b Median survival
Median survival
Group
Patients (n
Patients
Patients (n
Events
Median Lower
Upper
included)
(maximum n) at start)
(n)
OS
95% CI 95% CI
MYC
Median OS clinical
29
29
29
12
71
42
NA
BCL2
Median OS clinical
40
40
40
10
182
150
NA
MYC
Median OS genetic
29
29
29
12
19
18
NA
BCL2
Median OS genetic
40
40
40
10
106
62
NA
Median TTT clinical MYC
28
28
28
27
5
1.5
16
Median TTT clinical BCL2
40
40
40
22
48
30.0
NA
OS, overall survival; TTT, time to treatment; clinical, from clinical diagnosis; genetic, from genetic detection; n,
number; CI, confidence interval; NA, not available
Supplementary Table 5c Survival in cases with a MYC-translocation and either CLL or PLL
Survival
Group
Coefficient
Exp
SE
Z-value
Pr(>|z|)
(coefficient) (coefficient)
MYC with PLL
OS clinical
-0.0296
0.9708
0.6198
-0.048
0.96
MYC with PLL
OS genetic
0.2809
1.3243
0.6151
0.457
0.65
MYC with PLL
TTT clinical
0.3383
1.4025
0.4351
0.777
0.44
OS, overall survival; TTT, time to treatment; clinical, from clinical diagnosis; genetic, from genetic detection; Exp,
exponent; SE, standard error
The group “MYC with CLL” was considered as baseline reference. P-values reflect the statistical differences between
the two groups. Note that there was no statistical significant difference in OS, nor in TTT between CLL and PLL cases
with a MYC-translocation.
References
1.
Put N, Meeus P, Chatelain B, Rack K, Boeckx N, Nollet F, et al. Translocation t(14;18) is not associated with
inferior outcome in chronic lymphocytic leukemia. Leukemia. 2009;23(6):1201-4.