Name _______________________________________ Date ________ Must be completed by March 13, 2015. This webquest covers material which we have done already as review, and current material that we are covering in our current genetics unit. It can be filled out online in the word document and e-mailed to me, or printed and given to me. You may also hand write your answers neatly and submit it by the due date. Just get it done by 3/13! http://learn.genetics.utah.edu Run the entire Tour of the basics Answer these questions—in order through the slides/sections What is DNA? 1. DNA is found in the n_________ of cells. 2. It is in the form of structures called c_______________. Every human cell except sex cells (gametes) has 2 each of 23 kinds for a total of _____. 3. DNA means d_______________ r_____________, and it is the form of a d___________ h__________. 4. Each half the helix is made of units adenine ____, thymine ___, cytosine ___, and guanine ____. 5. Adenine always pairs with ___________ in the DNA, and cytosine always pairs with _______________. 6. The letters made up words composed of ____ letters each, and each word is called a codon. Codons tell the ribosomes of a cell the order of amino acids to link together into a protein. 7. The codons link together into sentences called g_______, and these g________ tell a cell how to make p_____________. What is a gene? 8. A gene is the instruction for making a type of p__________. 9. Each cell of our body contains about _____________ genes. Does a chromosome contain one gene or many genes? __________ 10. The disease sickle cell anemia is due to a m___________ in the gene that codes for hemoglobin protein. The job of hemoglobin is to allow r___ b_______ cells to carry O_________. People with sickle cell anemia have cells that _____________________________________. What is a chromosome? 11. If all the DNA in a single human cells were spread out end to end, its length would be _______________. 12. All this DNA can fit into a single cell because it is wrapped around special p________ to form c___________. 13. Do different species have the same number chromosomes? _______ 14. How many chromosomes in a human body cell, total? ________ How many types of chromosomes in a human cell? _______ How many of each type do fathers donate to offspring? ____Mothers? ___ 15. In the picture of a person’s chromosomes, males have an ____sex chromosome and a ____ sex chromosome, in addition to ___ other nonsex chromosomes, called autosomes. Females have two ____ sex chromosomes and ___ other autosomes. 16. How many chromosomes onions? ____Mosquitos? ___Carp? ___ What is a protein? 17. Our bodies contain about 100 _________________ cells. In these cells the machines that do work are molecules called _____________. 18. Animals feel pain because cells called n_________ send messages to the brain. Draw one of these cells. R ___________ proteins on the cells enable them to send messages to others lying end to end in a chain leading to the brain. Str___________ proteins give cells the special shape. 19. When its time for a cell to make a protein, the right gene is copied into a similar molecule called messenger __________. This process is called trans____________. Then this copy of a single gene, mRNA, goes to the cytoplasm where a r_______________ uses its instructions to link a___________ a______________ into a p_________ according to the order of words (3 letter codons) that were in the g_________. The process carried out to make the protein from the mRNA’s instructions is called trans___________. What is heredity? 20. H______________ is passing t________ from parents to their offspring. 21. Each human parent contributes a complete set of ___ chromosomes. 22. Males pass DNA to offspring in cells called gametes or ___________; females pass their DNA to offspring in gametes called ______ or ova. 23. The cell formed when sperm enters the egg is called a z___________. This cell d___________ many times to form huge number of cells in a baby. 24. Watch the animation carefully. Each parent must give exactly ____ of each chromosome to the child if it is to be healthy. 25. True or false. Which of his own two chromosomes (homologous chromosomes) of each type given by a father to his child is random. ________ 26. True or False. It is possible to predict which of her two chromosomes of each type a mother will donate to her child. ___________ 27. True or false. Every child of the same couple receives the same set of chromosomes from both mother and father. ___________ 28. Why does each child of a couple, except for identical twins, have a unique set of traits versus all the other children of the couple? ____________________________________________________________ ____________________________________________________________ 29. Why can some traits continue to be passed through generation after generation of a family, while other traits (e.g., a disease gene on one of the chromosomes) disappear over the generations? ____________________________________________________________ ____________________________________________________________ What is a trait? 30. A trait is ____________________________________________________________ 31. Some traits are ph_______________, like eye color, but some are be_____________. Is predisposition to a disease, like certain cancers obesity, a trait? (always, never, sometimes) __________________ 32. Are traits completely determined by DNA? _____Give an example that supports your answer. ____________________________________________________________ 33. Hitchhikers thumb is a recessive trait. Write genotypes for a person who: Does not have hitchhiker’s thumb & can not pass the trait _______ Does not have hitchhiker’s thumb, but can pass it to children (so, this person is a “carrier” of hitchhiker thumb trait. ________ Has hitchhiker’s thumb & can pass on the trait to offspring _______ 34. In #33, circle the genotype of the person who is homozygote and does not show the recessive hitchhiker thumb trait. ___________ Draw a rectangle around the person whose genotype is heterozygotic dominant. Write the genotype of the person whose phenotype is the recessive phenotype. _______ Does this person who shows the recessive trait have a homozygous or heterozygous phenotype? __________ 35. In the animation, both the mother and father have h___________________genotypes for hitchhiker’s thumb phenotype, and it is (?random or predetermined?) ____________________ which of the 2 different alleles—dominant allele H or recessive allele h—either passes on. 36. What is the difference in genotypes and phenotypes of a trait, like color in carnations, that is co-dominant versus a trait that a simple trait like hitchhiker’s thumb. Be specific. __________________________________________________________ Now return to the home page for http://learn.genetics.utah.edu Run the interactive tutorial: Build a karyotype. 37. Afterwards describe what you now know about karyotypes of humans, how they are made, and why they are useful. ____________________________________________________________ ____________________________________________________________ ____________________________________________________________ Now return to the home page for http://learn.genetics.utah.edu Go to DNA to protein and run Interactive tutorial: Build a DNA molecule Afterwards, describe what you know about the structure of DNA, how its copied, and why it’s important that all of its bases paired with complementary nucleotide bases. 38. __________________________________________________________ ____________________________________________________________ _________________________________________ http://wps.prenhall.com/esm_klug_essentials_5/17/4572/1170649.cw/content/i ndex.html Run the two animations and do the two exercises. In the exercises, you will be assigning genotypes to people whose phenotype is shown by shading. Carriers are shown by half-colored circles. Use the alleles H dominant or h recessive in these examples. 39. What is the genotype of a person who shows a dominant trait? _____ or _____ For a person who does not show a dominant trait? ______ 40. What is the genotype for a person who shows a recessive trait? ____For a person who does not show a recessive trait? ______ 41. If a trait is sex linked, it is coded by a gene on the _____ chromosome. What is the genotype of a women who has a recessive sex linked disorder, coded by the allele Xh? ______________ What is the genotype of a women who does not have the recessive disorder coded by Xh, but who can pass it on to her offspring? ______________ What is the genotype man who has a recessive sex linked disorder? ____________ What is the genotype of a man who does not have a sex linked disorder? _____________Why do men suffer sex linked recessive disorders more often than women? ____________________________________________________________ ____________________________________________________________ What is the reason that sex linked alleles are written above the X like this X H or Xh? ___________________________________________________________ 42. Write your answers for the 10 questions in the post quiz. Do not submit them online. 1 2 9 3 10 4 5 6 7 8 Now, examine your own family pedigrees. These are the inheritance patterns: Having a Widow’s peak—recessive trait Having a hitchhiker’s thumb—recessive trait Having dimples—a dominant trait Having ability to curl the tongue—a dominant trait Having curles—a dominant trait Having attached earlobe—a recessive trait. Chapter 14 in your text has a section on pedigrees that will help you, as well as the website you just used. Turn in your pedigrees with every persons possible genotypes labeled before you leave class today. http://www.phschool.com/science/biology_place/biocoach/inheritance/intr o.html This website will help you learn principles of Mendelian genetics. You can also study these in your textbook, chapter 11.1, 11.2. Click on the top file drawer of the genetic X files Click the orange eyes file. 43. What letter is used for the dominant allele?___ Recessive allele? _____ 44. What is the dominant phenotype? ______________The recessive phenotype? _________________ 45. Is the disorder sex linked? ___________ How can you tell? _______________________________________________________ 46. What genotype (s) code for an GenAlien having the recessive phenotype? ________________ What genotype (s) code for an GenAlien having the dominant phenotype? 47. Which generation is the F1 generation, 1st, 2nd, or 3rd? ______ P? ______ F2? __________ 48. Who must be mated to from an F2 generation? ____________________________________________________ Why don’t geneticist study F2 generations in people? _____________________________________________________ In the Egyptian pharoah’s families, were there any F2 generations? _____________________________________________________ 49. Draw the Punnett square for the F1 generation & the F2 generation. 50. What is the reason that a 2 x 2 square is needed to show all possible genotypes of offspring in a monohybrid cross? ____________________________________________________________ __________________________________________________ 51. What is the importance of the letters written inside the square? ______________________________________________________ 52. For the F1 generation in this cross, what was the phenotypic ratio of the children? (what fraction—in quarters-- had the dominant phenotype and the recessive phenotype) ______________________________________________________ 53. What is the genotypic ratio of the F1 offspring (how many quarters are OO, Oo, and oo? _____________________________________ 54. Why do orange eyes appear in the F2 generation and the P generation, but not in the F1 generation, and why is the ratio of black to orange 3:1 in the F2 generation? ____________________________________________________________ ____________________________________________________________