Guest Speakers Professor Christopher Crane, MD, is Program Director and Chief of the Gastrointestinal Section, and the Program Director of the residency and fellowship training programs in the Department of Radiation Oncology at the University of Texas M. D. Anderson Cancer Center. His primary research interest is in combining novel chemotherapeutic agents with radiotherapy in the treatment of gastrointestinal malignancies. He has conducted clinical trials in pancreatic and rectal cancer focusing on the combination of molecular targeted therapies with radiotherapy as well as correlative studies focused on the development of predictive markers. Dr Ian Penman, Consultant Physician, Gastroenterology trained in Medicine at Glasgow University and completed his Gastroenterology training in Edinburgh & Medical University of South Carolina, USA. He has been a Consultant Gastroenterologist at the Western General Hospital and Royal Infirmary Edinburgh since 1996.Within NHS Lothian he has held a number of positions including Clinical Lead, Gastroenterology, NHS Lothian, 2005- 2008, Clinical Lead, Diagnostic Collaborative Programme (Endoscopy), Lothian 2006-8 and Director, Endoscopy Unit, WGH 2000 – present. He is currently the Clinical Advisor /National Endoscopy Lead for Scotland and sits on the UK Joint Advisory Group (JAG) committee on Accreditation of Endoscopy Units. He is co-chair in the BSG working party on the future of EUS service provision and training in the UK, due to report in 2010. Ian has a variety of clinical interests including Endoscopic Ultrasound (EUS), Therapeutic endoscopy, Barrett’s oesophagus and Endoscopic diagnosis and management of GI cancers. He is currently involved in studies of cancer risk in Barrett’s oesophagus (AspECT) and endotherapy of early neoplasia in Barrett’s oesophagus. Dr Ian Penman is author or co-author of approximately 50 clinical and research papers, medical articles and book chapters. David C. Linehan, M.D. is an Associate Professor of Surgery in the Section of Hepatobiliary, Pancreatic and Gastrointestinal Surgery at Washington University School of Medicine. He received his Bachelor of Arts degree from Dartmouth College, graduating with distinction in 1986 and earned his Doctor of Medicine degree from the University of Massachusetts Medical School in 1990. Dr. Linehan completed his general surgery training in the Deaconess-Harvard Surgical Service at Harvard Medical School. During this time he also served as a research fellow in tumor immunology in the Laboratory of Biologic Cancer Therapy at Brigham and Women’s Hospital. Dr. Linehan completed his surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center in 1999. Dr. Linehan is the author of many basic science and clinical manuscripts and he currently directs a laboratory whose focus is on proteomic biomarker discovery in pancreas cancer and the cell-mediated immune response to cancer. Specifically, his investigations are exploring mechanisms of tumor-associated immune suppression and the design and development of immune-based therapies for the treatment of pancreas cancer. He currently serves on the Executive Council of the Society of Surgical Oncology and on the Scientiifc Program Committee of the American Society of Clinical Oncology. He is the recipient of an American Society of Clinical Oncology Young Investigator Award as well as the Evarts A. Graham Teaching Award at Washington University School of Medicine. In addition, Dr. Linehan is active in clinical investigation and serves as Principal Investigator on several on-going multi-modality clinical trials through the Siteman Cancer Center. Summary of Cancer-Related Activities 1. Large surgical practice focusing on hepatobiliary and pancreatic malignancy 2. NIH-funded research laboratory in cancer immunity 3. Multiple cancer-related publications in peer-review journals 4. Principal Investigator of several on-going clinical trials in cancer 5. Research grant from Cancer Treatment Research Foundation for study of proteomics profiling in pancreas cancer patients. 6. Ad hoc reviewer for Clinical Cancer Research, Journal of Immunology, Blood, Journal of the American College of Surgeons, Annals of Surgical Oncology 7. Member of the Protocol Review and Monitoring Committee 8. Active Member of several cancer associations a. Society of Surgical Oncology b. American Society of Clinical Oncology c. Society of University Surgeons d. American Association of Cancer Research e. American College of Surgeons Oncology Group f. Siteman Cancer Center Dushyant V. Sahani, MD, is Associate Professor of Radiology at Harvard Medical School and Director of Computed Tomography at Massachusetts General Hospital, both in Boston, Massachusetts. Dr. Sahani a board certified radiologist and fellowship trained in abdominal imaging and intervention at Massachusetts General Hospital and Harvard Medical School. Imaging of the Liver, Biliary and Pancreas has been a focus of his research and clinical work. He is currently involved in investigating tumor angiogenesis and response to novel cancer treatment methods with CT, MRI and PET. Dr. Sahani has contributed over 125 original articles and reviews to the medical literature, as well as numerous book chapters. His work has appeared in journals such as the New England Journal of Medicine, Nature Medicine, Radiology, American Journal of Radiology, Journal of Computer Assisted Tomography, Annals of Surgery, Journal of Gastrointestinal Radiology and Hepatology, Investigative Radiology and Academic Radiology. He has done various lectures nationally and internationally. Dr. Sahani has also provided medical education to residents, fellows, and HMS students. In addition, he has been a visiting professor at various universities in the United States and abroad. He is a reviewer for 15 scientific journals. Dr Sahani is also a fellow member of all leading radiology societies including RSNA, ACR, SCBT/MR, SGR, ARRS, NERRS, CMR. In 2005 and 2007, he has earned research award from the Society of Gastrointestinal Radiology and Hounsfeild award from the Society of Computed Body Tomography and MR in 2005. He has been appointed 2008-2009 “Visiting professor” of the Society of Gastrointestinal Radiology. Dr. Eileen M. O’Reilly is an Associate Member in the GI Medical Oncology service at Memorial SloanKettering Cancer Center (MSKCC) in New York and an Associate Professor of Medicine at Weill Medical College of Cornell University. Dr. O’Reilly received her medical degree at Trinity College (Dublin University) in Ireland, where she was born. She completed her residency training in Ireland and fellowship training at MSKCC and has been a faculty member in the GI Oncology service at MSKCC since that time. Dr. O’Reilly has pancreatic, biliary, neuroendocrine and primary liver cancers as the major focus of her clinical and research activities. Research initiatives include integration of molecularbased therapies for the treatment of pancreas cancer along with development of adjvuant and neoadjuvant therapy. At a national level, Dr. O’Reilly is a member of CALGB’s GI committee and also participates in RTOG and ACOSOG. Dr. O’Reilly’s institutional administrative commitments include participation in MSKCC’s IRB, Research and Clinical Councils and electronic chemotherapy order entry committees. Dr. O’Reilly is also the current President of the MSKCC medical staff. Michael Goggins is a Professor of Pathology, Medicine and Oncology in the Divisions of Gastroenterology/ Hepatology and Gastrointestinal Pathology and an Attending Physician in the Department of Medicine at the Johns Hopkins Medical Institutions, Baltimore, MD, USA. Professor Goggins is a 1988 graduate of Trinity College Dublin. He did his internal medicine and gastroenterology training in St. James' hospital, Dublin and Johns Hopkins University. He was a Lecturer in Medicine in Trinity College from 1992-1995. He obtained his Membership of the Royal College of Physicians of Ireland in 1991, and his European Diploma in Gastroenterology in 1995. He joined the faculty at Johns Hopkins in 1999 and is Director of the Pancreatic Cancer Early Detection Laboratory. His research interests include the early detection of pancreatic neoplasia through molecular markers, screening and familial susceptibility gene discovery and identifying genetic and epigenetic alterations that contribute to pancreatic cancer development. Professor Parul J Shukla, MS, FRCS, is Chief of Gastro-Intestinal & HPB Surgical Oncology at the Tata Memorial Hospital, India’s largest cancer centre and located in Mumbai. He graduated from the Grant Medical College, Mumbai, and underwent surgical training initially in India and then in the UK and Australia. Currently, he is a National Co-editor of the journal ‘Hepatogastroenterology’ and on the Editorial Board of the World Gastroenterology Organisation. In addition, he is the Chairman of the Indian Gastric Cancer task-force and the Editor-in-Chief of the ‘Journal of Colorectal Diseases’. Dr Shukla has an active interest in clinical research in pancreatic cancer, improving outcomes of surgery, and has many publications on these topics. He is also visiting Professor to a number of Medical Schools (in India and Romania)