UC IRVINE INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE APPENDIX K VARIATIONS IN STANDARD HOUSING AND/OR HUSBANDRY Lead Researcher Name: Type here Standard ULAR-provided husbandry and care of laboratory animals in the vivarium consists of the following: Standard species-appropriate caging (solid-bottom cages for rodents) Primary housing space and secondary (housing room) temperature and humidity levels conforming to specifications in the Guide Species-appropriate physical/psychological enrichment and exercise Standard food and tap water provided ad-libitum 12-hour light-dark cycle ULAR-determined standard cleaning and sanitation schedule Researchers planning any variation of the items listed above, or any other deviation from standard ULAR-provided husbandry and care of research animals must provide the following information: 1. Describe in detail the deviation from ULAR standard housing/care: Type here 2. Provide a scientific justification for the variation: Type here 3. Use of Wire-Bottom Caging: Please review the IACUC Policy on Housing Rodents on Wire Flooring. a. Use of wire-bottom caging has been associated with the development of foot sores in rodents. Describe how animals will be monitored for this potential adverse side effect: Type here b. How will animals be treated if they develop foot sores or other complications associated with the use of wire bottom caging: Type here 4. Food or Water Restriction: Please review the IACUC Policy on Food or Fluid Restriction . a. Describe how the weight and hydration status of the animals will be monitored: Type here Appendix K 1 [ ] By checking this box, the Lead Researcher and all research personnel assure that they will keep a food/water log in the housing room with the animals at all times. 5. Special diet or additions to water: a. Describe in detail the special diet or addition to regular drinking water: Type here b. Indicate who will provide the special diet and/or water: [ ] Research staff [ ] ULAR husbandry staff 6. For all other variations to standard husbandry, please describe the variation in detail and any special monitoring or care that animals will require associated with the variation. Be specific: Type here [ ] By checking this box, the Lead Researcher and all research personnel assure that they have reviewed and fully understand all applicable policies and guidelines pertaining to the type of variance listed above and will comply with all requirements. Appendix K 2