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Curriculum Vitae
February 16, 2016
Mei-Ping Kung
Home Address:
525 Foxglove Lane
Wynnewood, PA 19096
Tel.: (484) 270-8175
e-mail: kungmp@gmail.com
Social Security Number: 391-68-2507
Education:
1968-1972
1973-1975
1978-1982
B.S. National Taiwan University, Agricultural Chemistry
M.S. State University of New York at Buffalo, Biochemical Pharmacology
Ph.D. State University of New York at Buffalo, Biochemical Pharmacology
Postgraduate Training:
1975-1977
1977-1978
1978-1982
1984-1985
1987-1988
1988-1989
Research Associate, Department of Biochemical Pharmacology, State University of
New York at Buffalo
Senior Research Assistant, Department of Pediatrics, Children's Hospital,
State University of New York at Buffalo
Research Assistant, Department of Biochemical Pharmacology, State University of
New York at Buffalo (part time)
Postdoctoral Pharmacologist, Department of Nuclear Medicine, State University of
New York at Buffalo
Senior Research Scientist, Department of Radiology, University of Pennsylvania
Research Associate, Department of Psychiatry, University of Pennsylvania
Faculty Appointments:
1985-1987
Research Assistant Professor, Department of Pharmacology and Therapeutics,
SUNY Buffalo
1989-1993
Research Assistant Professor of Pharmacology, Department of Psychiatry,
University of Pennsylvania
1993-1995
Research Assistant Professor of Biochemical Pharmacology, Department of
Radiology, University of Pennsylvania
1995-2009
Research Associate Professor of Biochemical Pharmacology, Department of
Radiology, University of Pennsylvania
2007-2008
Adjunct Professor, Department of Radiopharmaceutical Science, Beijing Normal
University, Beijing, China.
2007-present Adjunct Professor, Department of Medical Imaging and Radiological Sciences,
Chang Gung University, Taiwan.
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20092009200920092009-
Adjunct faculty, Department of Radiology, University of Pennsylvania
Adjunct Professor, Department of Biomedical Engineering and Environment
Science, National Tsing Hua University, Taiwan.
Consultant for Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan.
Consultant for Avid Radiopharmaceuticals, Inc, Pennsylvania
Consultant for Institute of Nuclear Energy Research, Taiwan.
Memberships in Professional and Scientific Societies:
Society of Neuroscience
Awards:
Springer Award by European Journal of Nuclear Medicine—Best Basic Paper Science in 1997
Society of nuclear Medicine-Best animal picture of the year, 2007
Bibliography
Original papers
1.Ho YK, Kung MP, Bardos TJ. Oligonucleotides containing modified bases. I. Inhibition of DNA and
RNA polymerases by partially thiolated oligocytidylic acids. Biochem Biophys Res Commun 73:903910, 1976.
2.Kung MP, Ho YK, Bardos TJ. Action of partially thiolated poly-nucleotides on the DNA polymerasealpha from regenerating rat liver. Cancer Res 36:4537-4542, 1976.
3.Rattazzi MC, McCullough RA, Downing CJ, Kung MP. Toward enzyme therapy in Gm2
ganglionsidosis: b-hexosaminidase infusion in normal cats. Pediat Res 13:916-923, 1979.
4.Kung MP, Ho YK, Bardos TJ. 5-mercaptopolyuridylic acid (MPU), a potent inhibitor of the reverse
transcriptase from avian myeloblastosis virus. Res Commun Chem Pathol Pharmacol 36:215-228, 1982.
5.Kung MP, Ho YK, Lalka D, Bardos TJ. Pharmacokinetics and metabolism of partially thiolated
polycytidylic acid (MPC) in rodents. Cancer Res 44:4602-4604, 1984.
6.Kung MP, Kostyniak P, Olson JR, Malone MA, Roth JA. Studies of the in vitro effect of
methylmercury chloride on rat brain neurotransmitter enzymes. J Appl Toxicol 7:119-121, 1987.
7.Kung MP, Roth JA. Cellular localization of soluble and membrane-bound forms of arylsulfatase in rat
brain. Brain Res 419:141-146, 1987.
8.Kung HF, Kasliwal R, Pan S, Kung MP, Mach RH, Guo YZ. Dopamine D2 receptor imaging
radiopharmaceuticals: synthesis, radiolabeling and in vitro binding of R-(+) and S-(-)3-iodo-2-hydroxy2
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6-methoxy- N-[(1-ethyl)-2-pyrrolidinyl)methyl] benzamide (IBZM). J Med Chem 31:1039-1043, 1988.
9.Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Lein PJ, Roth JA. Effect
of short-term exposure to hexachlorophene on rat brain cell specific marker enzymes. Fundam Appl
Toxicol 11:519-527, 1988.
10. Kung MP, Spaulding SW, Roth JA. Desulfation of 3,5,3'-triiodo-thyronine sulfate by microsomal
sulfatase from human and rat tissues. Endocrinology 122:1195-1200, 1988.
11. Billings JJ, Kung MP, Chumpradit S, Pan S, Kung HF. [125I]FISCH: a new CNS D1 dopamine
receptor imaging ligand. Life Sci 45:711-718, 1989.
12. Chumpradit S, Kung HF, Billings JJ, Kung MP, Pan S. [125I]FISCH, (±)-8-chloro-2,3,4,5tetrahydro-3-methyl-5-(4'-[125I] iodophenyl)-1H-3-benzazepine-7-ol: a potential CNS D1 dopamine
receptor imaging agent. J Med Chem 32:1431-1435, 1989.
13. Kung HF, Pan S, Kung MP, Billings JJ, Kasliwal R, Reilley J, Alavi A. In vitro and in vivo
evaluation of [123I]IBZM: a potential CNS D2 dopamine receptor imaging agent. J Nucl Med 30:88-92,
1989.
14. Kung MP, Kostyniak PJ, Olson JR, Sansone FM, Nickerson PA, Malone MA, Ziembiec N, Roth
JA. Cell specific enzyme markers as indicators of neurotoxicity: effects of acute exposure to
methylmercury. Neurotoxicology 10:41-52, 1989.
15. Kung MP, Kung HF. Peracetic acid as a superior oxidant for preparation of [123I]IBZM: a potential
dopamine D2 receptor imaging agent. J Lab Compds Radiopharm 27:691-700, 1989.
16. Kung MP, Nickerson PA, Sansone FM, Olson JR, Kostyniak PJ, Adolf MA, Roth JA. Effect of
chronic exposure to hexachlorophene on rat brain cell specific marker enzymes. Neurotoxicology
10:201-210, 1989.
17. Schonwetter BS, Luedtke RR, Kung MP, Billings JJ, Kung HF, Molinoff PB. Characterization of
membrane-bound and soluble D2 receptors in canine caudate using [125I]IBZM. J Pharmacol Exp Ther
250:110-116, 1989.
18. Kung HF, Alavi A, Chang W, Kung MP, Velchik M, Keyes JW Jr, Billings JJ, Pan S, Noto R,
Rausch A, Reilley J. In vivo SPECT imaging of D2 dopamine receptors: initial studies with [123I]IBZM
in humans. J Nucl Med 31:573-579, 1990.
19. Kung HF, Liu BL, Mankoff D, Kung MP, Billings JJ, Francesconi LC, Alavi A. A new myocardial
imaging agent: synthesis, characterization and biodistribution of [68Ga]BAT-TECH. J Nucl Med
31:1635-1640, 1990.
20. Kung HF, Ohmomo Y, Kung MP. Current and future radiopharmaceuticals for brain imaging with
single photon emission computed tomography. Sem Nucl Med 10:290-302, 1990.
21. Kung MP, Kung HF, Billings JJ, Yang Y, Murphy RA, Alavi A. The characterization of IBF as a
new selective dopamine D2 receptor imaging agent. J Nucl Med 31:648-654, 1990.
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22. Murphy RA, Kung HF, Kung MP, Billings JJ. Synthesis and characterization of iodobenzamide
analogs: potential D2 dopamine receptor imaging agents. J Med Chem 33:171-178, 1990.
23. Chumpradit S, Kung MP, Billings JJ, Kung HF. Synthesis and resolution of (+)7-chloro-8-hydroxy1-(3’-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzapine (TISCH): a high affinity and selective
iodinated ligand for CNS D1 dopamine receptor. J Med Chem 34:877-883, 1991.
24. John CS, Kung MP, Billings JJ, Kung HF. Preparation, radiolabeling and biodistribution of a new
class of bisaminothiol (BAT) ligands as possible imaging agents. Int J Nucl Med Biol 18:551-556, 1991.
25. Kung MP, Liu BL, Yang YY, Billings JJ, Kung HF. A kit formulation for the preparation of
[123I]IBZM: a new CNS D2 dopamine receptor imaging agent. J Nucl Med 32:339-342, 1991.
26. McPherson DW, Lisic E, Knapp FF Jr, Ambrose KR, Lambert CR, Kung MP, Kung HF. Synthesis
and evaluation of two radioiodinated iodoalkenyl-substituted spiroperidol analogues. Nucl Compact
22:92-98, 1991.
27. Billings JJ, Kung MP, Chumpradit S, Mozley PD, Alavi A, Kung HF. Characterization of
radioiodinated TISCH: a high affinity and selective ligand for mapping CNS D1 dopamine receptor. J
Neurochem 58:227-236, 1992.
28. Chumpradit S, Kung MP, Panyachotipun C, Prapansiri V, Foulon C, Brooks BP, Szabo SA, TejaniButt S, Frazer A, Kung HF. Iodinated tomoxetine derivatives as selective ligands for serotonin and
norepinephrine uptake sites. J Med Chem 35:4492-4497, 1992.
29. Kung MP, Chumpradit S, Billings JJ, Kung HF. 4-Iodotomoxetine: a novel ligand for serotonin
uptake sites. Life Sci 51:95-106, 1992.
30. Ohmomo Y, Francesconi LC, Kung MP, Kung HF. New conformationally restricted Tc-99m N2S2
complexes as myocardial perfusion imaging agents. J Med Chem 35:157-162, 1992.
31. Spaulding SW, Smith TJ, Hinkle PM, Davis FB, Kung MP, Roth JA. Studies on the biological
activity of triiodothyronine sulfate. J Clin Endo Metab 74:1062-1067, 1992.
32. Billings JJ, Guo YZ, Kung MP, Kung HF. Localization of IBF as a D2 dopamine receptor imaging
agent in nonhuman primates. Eur J Nucl Med 20(12):1146-1153, 1993.
33. Canney DJ, Guo YZ, Kung MP, Kung HF. Synthesis and preliminary evaluation of an iodovinyltetrabenazine analog as a marker for the vesicular monoamine transporter. J Lab Compds Radiopharm
33:355-368, 1993.
34. Chumpradit S, Kung MP, Billings JJ, Mach R, Kung HF. Fluorinated and iodinated dopamine
agents: D2 imaging agents for PET and SPECT. J Med Chem 36:221-228, 1993.
35. Foulon C, Kung MP, Kung HF. Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-(-3'-iodo-2'-propenyl)N-n-propyl]aminotetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand. J Med Chem
36:1499-1500, 1993.
36. Guo YZ, Kung MP, Cheng HJ, Pfeiffer N, Mozley PD, Kung HF. A simplified method for
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quantitation of [123I]IBZM in human plasma: a technical note. Eur J Nucl Med 20:373-378, 1993.
37. Kung MP, Kung HF, Chumpradit S, Foulon C. In vitro binding of a novel dopamine D3 receptor
ligand:[125I]trans-7-OH-PIPAT-A. Eur J Pharmacol 235:165-166, 1993.
38. Zhuang ZP, Kung MP, Kung HF. Synthesis of (R,S)trans-8-hydroxy-2-(N-n-propyl-N-3'-iodo-2'propenyl) aminotetralin (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand. J Med Chem 36:31613165, 1993.
39. Burris KD, Filtz TM, Chumpradit S, Kung MP, Foulon C, Hensler JG, Kung HF, Molinoff PB.
Characterization of [125I]trans-7-hydroxy-2-[N-propyl-N-(3’-iodo-2’-propenyl)amino]tetralin binding to
dopamine D3 receptors in rat olfactory tubercle. J Pharmacol Exp Ther 268(2):935-942, 1994.
40. Chumpradit S, Kung MP, Kung HF. Synthesis and optical resolution of (R) and (S)trans-7-hydroxy2-[N-n-propyl[N[3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand. J Med Chem
36:4308-4312, 1994.
41. Chumpradit S, Kung MP, Vessotskie JM, Mu M, Kung HF. Iodinated 2-aminotetralins and 3amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors. J Med Chem 37:4245-4250, 1994.
42. Francesconi LC, Yang YY, Kung MP, Zhang XX, Billings JJ, Guo YZ, Kung HF. Technetium-99m
N,N'-bis(2-mercapto-2-methylpropyl)-2-aminobenzylamine: technetium-99m complexes of a novel
bis(aminoethanethiol) ligand. J Med Chem 37:3282-3288, 1994.
43. Garner SE, Kung MP, Foulon C, Chumpradit S, Kung HF. [125I](S)trans-7-OH-PIPAT: a potential
SPECT imaging agent for sigma binding sites. Life Sci 54:593-603, 1994.
44. Goodman MM, Kung MP, Kabalka GW, Kung HF, Switzer R. Synthesis and characterization of
radioiodinated N-(3-iodopropen-2-yl)-2ß-carbomethoxy-3ß-(4-chlorophenyl)tropanes: potential
dopamine reuptake site imaging agents. J Med Chem 37:1535-1542, 1994.
45. Kung HF, Kung MP, Clarke W, Maayani S, Zhuang ZP. A potential 5-HT1A receptor antagonist: pMPPI. Life Sci 55(19):1459-1462, 1994.
46. Kung MP, Canney DJ, Frederick D, Zhuang Z, Billings JJ, Kung HF. Binding of
[125I]iodovinyltetrabenazine ([125I]TBZ) to CNS vesicular monoamine transport sites. Synapse 18:225232, 1994.
47. Kung MP, Chumpradit S, Frederick D, Garner SE, Burris KD, Molinoff PB, Kung HF.
Characterization of binding sites for [125I]R(+)trans-7-OH-PIPAT in rat brain. Arch Pharmacol 350:611617, 1994.
48. Kung MP, Zhuang ZP, Frederick D, Kung HF. In vivo binding of [123I]4-(2’-methoxy-phenyl)-1-[2’(n-2”-pyridinyl)-p-iodobenzamido-]ethyl-piperazine, p-MPPI, to 5-HT1A receptors in rat brain. Synapse
18:359-366, 1994.
49. Zhuang ZP, Kung MP, Chumpradit S, Mu M, Kung HF. Derivatives of 4-(2’-methoxy-)phenyl-1[2’-(N-2”-pyridinyl-)-p-iodobenzamido-]ethyl-piperazine (p-MPPI) as 5-HT1A ligands. J Med Chem
37:4572-4575, 1994.
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50. Zhuang ZP, Kung MP, Kung HF. Synthesis and evaluation of 4-(2’-methoxy)phenyl-1-[2’-(N-2”pyridinyl-)-p-iodobenzamido-]ethyl-piperazine (p-MPPI): a new iodinated 5-HT1A ligand. J Med Chem
37:1406-1407, 1994.
51. Burris KD, Pacheco MA, Filtz TM, Kung MP, Kung HF, Molinoff PB. Lack of discrimination by
agonists for D2 and D3 dopamine receptors. Neuropsychopharmacology 12(4):335-345, 1995.
52. Canney DJ, Kung MP, Kung HF. Amino- and amido-tetrabenazine derivatives: synthesis and
evaluation as potential ligands for the vesicular monoamine transporter. Nucl Med Biol 22:527-535,
1995.
53. Chumpradit S, Kung MP, Vessotskie JM, Kung HF. Synthesis, resolution and radioiodination of S()trans-5-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin (S(-)trans-5-OH-PIPAT): a new
dopamine D2-like receptor ligand. J Lab Compds Radiopharm 36:1051-1062, 1995.
54. Kung MP, Essman WD, Frederick D, Meegalla S, Goodman M, Mu M, Lucki I and Kung HF. IPT:
a novel iodinated ligand for the CNS dopamine transporter. Synapse 20:316-324, 1995.
55. Kung MP, Frederick D, Mu M, Zhuang ZP, Kung HF. [125I]p-MPPI (4-(2'-methoxy-phenyl)-1-[2'(n-2"-pyridinyl)-p-iodobenzamido-]ethyl-piperazine) as a new selective imaging radioligand of 5-HT1A
sites in rat brain. In vitro binding and autoradiographic studies. J Pharmacol Exp Ther 272:429-437,
1995.
56. Malison RT, Vessotskie JM, Kung MP, McElgin WT, Romaniello G, Kim HJ, Goodman MM,
Kung HF. Striatal dopamine transporter imaging in non-human primates with iodine-123-IPT SPECT. J
Nucl Med 36:2290-2297, 1995.
57. Meegalla SK Plössl K, Kung MP, Stevenson DA, Liable-Sands LM, Rheingold AL, Kung HF. First
example of a Tc-99m complex as a dopamine transporter imaging agent. J Am Chem Soc 117:1103711038, 1995.
58. Mozley PD, Stubbs JB, Kim HJ, McElgin W, Chumpradit S, Kung MP, Romaniello G, Kung HF.
Dosimetry of a D2/D3 dopamine receptor antagonist that can be used with PET or SPECT. J Nucl Med
36:1322-1331, 1995.
59. Oya S, Kung MP, Frederick D, Kung HF. New bisaminoethanethiol(BAT) ligands which form two
interconvertible Tc-99m complexes. Nucl Med Biol 22:749-757, 1995.
60. Vessotskie JM, Kung MP, Chumpradit S, Romaniello G, McElgin W, Frederick D, Malison RT,
Kung HF. In vitro and in vivo characterization of R(+)FIDA2: a novel dopamine D2/D3 imaging agent. J
Nucl Med 36:1282-1288, 1995.
61. Zhuang ZP, Kung MP, Clarke W, Maayani S, Mu M, Kung HF. Synthesis of R(+)- and S(-)-trans8hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin (trans-8-OH-PIPAT): new 5-HT1A
receptor ligands. Chirality 7:452-458, 1995.
62. Kung HF, Frederick D, Kim HJ, McElgin WT, Kung MP, Mu M, Mozley PD, Vessotskie JM,
Stevenson DA, Kushner SA, Zhuang ZP. In vivo SPECT imaging of 5-HT1A receptors with [123I]p-MPPI
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in nonhuman primates. Synapse 24:273-281, 1996.
63. Kung HF, Kim HJ, Kung MP, Meegalla SK, Plössl K, Lee HY. Imaging of dopamine transporters in
humans with technetium-99m TRODAT-1. Eur J Nucl Med 23(11):1527-1530, 1996.
64. Kung HF, Stevenson DA, Zhuang ZP, Kung MP, Frederick D, Hurt SD. New 5-HT1A receptor
antagonist: [3H]p-MPPF. Synapse 23:344-346, 1996.
65. Kung MP, Mu M, Zhuang ZP, Kung HF. NCS-MPP (4-(2'-methoxy-phenyl)-1-[2'-(N-2''-pyridyl)-pisothiocyanobenzamido]-ethyl-piperazine): a high affinity and irreversible 5-HT1A receptor ligand. Life
Sci 58:177-186, 1996.
66. Mach RH, Nader MA, Ehrenkaufer RLE, Line SW, Smith CR, Luedtke RR, Kung MP, Kung HF,
Lyons D, Merton TE. Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly
to dopamine D2 receptors: in vitro binding studies and positron emission tomography. Synapse 24:322333, 1996.
67. Meegalla SK, Plössl K, Kung MP, Stevenson DA, Frederick D, Kung HF. Tc-99m labeled tropanes
as dopamine transporter imaging agents. Bioconj Chem 7:421-429, 1996.
68. Mozley PD, Stubbs JB, Kim HJ, McElgin WT, Kung MP, Meegalla SK, Kung HF. Dosimetry of an
iodine-123-labeled tropane to image dopamine transporters. J Nucl Med 37:151-159, 1996.
69. Mozley PD, Kim HJ, Gur RC, Tatsch K, Muenz LR, McElgin WT, Kung MP, Mu M, Myers AM,
Kung HF. Iodine-123-IPT SPECT imaging of CNS dopamine transporters: nonlinear effects of normal
aging on striatal uptake values. J Nucl Med 37:1965-1970, 1996.
70. Oya S, Kung MP, Frederick D, Kung HF. Novel TcVO(III) N2S2 complexes: interconversion by
redox reaction. Nucl Med Biol 23:589-593, 1996.
71. Allen AR, Singh A, Zhuang ZP, Kung MP, Kung HF, Lucki I. The 5-HT1A receptor antagonist
p-MPPI blocks responses mediated by postsynaptic and presynaptic 5-HT1A receptors. Pharmacol
Biochem Behav 57:301-307, 1997.
72. Kung MP, Stevenson DA, Plössl K, Meegalla SK, Beckwith A, Essman WD, Mu M, Lucki I, Kung
HF. [99mTc]TRODAT-1: a novel technetium-99m complex as a dopamine transporter imaging agent. Eur
J Nucl Med 24:372-380, 1997.
73. Kung MP, Stevenson DA, Zhuang ZP, Vessotskie JM, Chumpradit S, Sun XM, Kung HF.
Characterization of a novel iodinated ligand, IPMPP, for human dopamine D4 receptors in CHO cells.
Life Sci 60:91-100, 1997.
74. Meegalla SK, Plössl K, Kung MP, Chumpradit S, Stevenson DA, Kushner SA, McElgin WT,
Mozley PD, Kung HF. Synthesis and characterization of Tc-99m labeled tropanes as dopamine
transporter imaging agents. J Med Chem 40:9-17, 1997.
75. Shiue CY, Shiue GG, Mozley PD, Kung MP, Zhuang ZP, Kim HJ, Kung HF. p-[18F]MPPF: a
potential radioligand for PET studies of 5-HT1A receptors in humans. Synapse 25:147-154, 1997.
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76. Staley JK, Talbot JZ, Ciliax BJ, Miller GW, Levey AI, Kung MP, Kung HF, Mash DC. Radioligand
binding and immunoautoradiographic evidence for a lack of toxicity to dopaminergic nerve-terminals in
human cocaine overdose victims. Brain Res 747:219-229, 1997.
77. Vessotskie JM, Kung MP, Chumpradit S, Kung HF. Characterization of [125I]S(-)5-OH-PIPAT
binding to dopamine D2-like receptors expressed in cell lines. Neuropharmacol 36:999-1007, 1997.
78. Vessotskie JM, Kung MP, Chumpradit S, Kung HF. Quantitative autoradiographic studies of
dopamine D3 receptors in rat cerebellum using [125I]S(-)5-OH-PIPAT. Brain Res 778:89-98, 1997.
79. Efange SMN, Kamath AP, Khare AB, Kung MP, Mach RH, Parsons SM. N-Hydroxyalkyl
derivatives of 3 -phenyltropane and 1-methylspiro[1H-indoline-3,4’-piperidine]: vesamicol analogues
with affinity for monoamine transporters. J Med Chem 40:3905-3914, 1997.
80. Goodman MM, Keil R, Shoup TM, Eshima D, Eshima L, Kilts CI, Votaw J, Camp VM, Votaw D,
Smith E, Kung MP, E. M, Watts R, Huerkamp M, Wu D, Garcia E, Hoffman JM. Fluorine-18-FPCT: A
PET radiotracer for imaging dopamine transporters. J Nucl Med 38:119-126, 1997.
81. Dresel SHJ, Kung MP, Plössl K, Meegalla SK, Kung HF. Pharmacological effects of dopaminergic
drugs on in vivo binding of [99mTc]TRODAT-1 to the central dopamine transporter in rats. Eur J Nucl
Med 25:31-39, 1998.
82. Zhuang ZP, Kung MP, Mu M, Kung HF. Isoindolin-1-one analogs of 4-(2’-methoxy-) phenyl-1-[2’(N-2”-pyridyl-)p-iodobenzamido-]ethylpiperazine (p-MPPI) as 5-HT1A receptor ligands. J Med Chem
41:157-166, 1998.
83. Meegalla SK, Plössl K, Kung MP, Stevenson DA, Mu M, Kushner S, Liable-Sands LM, Rheingold
AL, Kung HF. Specificity of diastereomers of [99mTc]TRODAT-1 as dopamine transporter imaging
agents. J Med Chem 41:428-436, 1998.
84. Oya S, Plössl K, Kung MP, Stevenson DA, Kung HF. Small and neutral TcO(V) BAT,
bisaminoethanethiol (N2S2) complexes for developing new brain imaging agents. Nucl Med Biol
25:135-140, 1998.
85. Kushner SA, McElgin WT, Kung MP, Mozley PD Plössl K, Meegalla SK, Mu M, Dresel SHJ,
Vessotskie JM, Lexow N, Kung HF. Kinetic modeling of [99mTc]TRODAT-1: A novel compound for
imaging the dopamine transporter. J Nucl Med 40:150-158, 1998.
86. Dresel SHJ, Kung MP, Huang XF, Plössl K, Hou C, Meegalla SK, Patselas G, Mu M, Saffer JR,
Kung HF. Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons. J
Nucl Med 40:660-666, 1999.
87. Zhuang ZP, Plössl K, Kung MP, Mu M, Kung HF. Neutral and stereospecific Tc-99m complexes:
[99mTc]N-benzyl-3,4-Di-(N-2-mercaptoethyl)-amino-pyrrolidines. Nucl Med Biol 26:217-224, 1999.
88. Oya S, Kung MP, Acton PD, Hou C, Mu M, Kung HF. A new single-photon emission computed
tomography imaging agent for serotonin transporters: [123I]IDAM: 5-iodo-2-((2((dimethylamino)methyl)phenyl)thio)benzyl alchohol. J Med Chem 42:333-335, 1999.
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89. Zhuang ZP, Kung MP, Mu M, Kung HF.99mTc-labeled MIBG derivatives: novel 99mTc complexes as
myocardial imaging agents for sympathetic neurons. Bioconj Chem 10:159-168, 1999.
90. Dresel SHJ, Kung MP, Huang XF, Plössl K, Hou C, Shiue CY, Karp J, Kung HF. In vivo imaging
of serotonin transporters with [Tc-99m]TRODAT-1 in non-human primates. Eur J Nucl Med 26:342347, 1999.
91. Acton PD, Kushner SA, Kung MP, Mozley PD, Plössl K, Kung HF. Simplified reference region
model for the kinetic analysis of [99mTc]TRODAT-1 binding to dopamine transporters in non-human
primates using SPECT. Eur J Nucl Med 26:518-526, 1999.
92. Choi SR, Kung MP, Plössl K, Meegalla S, Kung HF. An improved kit formulation of [Tc99m]TRODAT-1: a dopamine transporter imaging agent. Nucl Med Biol 26:461-466, 1999.
93. Kung MP, Hou C, Oya S, Mu M, Acton PD, Kung HF. Characterization of [123I]IDAM as a novel
single photon emission tomography tracer for serotonin transporters. Eur J Nucl Med 26: 844-853, 1999.
94. Acton PD, Kung MP, Mu M, Plössl K, Hou C, Siciliano M, Oya S, Kung HF. Single-photon
emission tomography imaging of serotonin transporters in the non-human primate brain with the
selective radioligand [123I]IDAM. Eur J Nucl Med 26:854-861, 1999.
95. Mu M, Kung MP, Plössl K, Acton PD, Mozley PD, Kung HF. A simplified method to determine
[99mTc]TRODAT-1 in human plasma. Nucl Med Biol 26:821-825, 1999.
96. Xu Y, Choi SR, Kung MP, Kung HF. Synthesis of radioidoinated 1-deoxy-nojirimycin derivatives:
novel glucose analogs. Nucl Med Biol 26:833-839, 1999.
97. Zhuang ZP, Choi SR, Hou C, Mu M, Kung MP, Acton PD, Kung HF. A novel serotonin transporter
ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol(ODAM) Nucl Med Biol 27:169175, 2000.
98. Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM-Y. In vivo detection of
amyloid plaques in a mouse model of Alzheimer’s disease. PNAS 97:7609-7614, 2000.
99. Oya S, Choi SR, Hou C, Mu M, Kung MP, Acton PD, Siciliano M, Kung HF. 2-((2((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter
ligand. Nucl Med Biol 27:249-254, 2000.
100.Wang Y, Xu R, Sasaoka T, Tonegawa S, Kung MP, Sankoorikal E-B. Dopamine D2 long receptordeficient mice display alterations in straitum-dependent functions. J Neurosci 20(22):8305-8314, 2000.
101.Choi SR, Hou C, Oya S, Mu M, Kung MP, Siciliano M, Acton PD, Kung HF. Selective in vitro and
in vivo binding of [125I]ADAM to serotonin transporters in rat brain. Synapse 38:403-412, 2000.
102. Kung HF, Wey S-P, Kung MP. SPECT imaging agents for dopamine and serotonin transporters in
the brain. Ann Nucl Med Sci 13:165-174, 2000.
103.Stanwood GD, Artymyshyn RP, Kung MP, Kung HF, Lucki I, McGonigle P. Quantitative
autoradiographic mapping of rat brain dopamine D3 binding with. J Pharmacol Exp Ther 295(3):12239
10
1231, 2000.
104.Zhuang ZP, Kung MP, Hou C, Skovronsky D, Gur TL, Plössl K, Trojanowski JQ, Lee VM-Y,
Kung HF. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem
44:1904-1915,2001.
105.Lee C-W.; Zhuang, Z.-P.; Kung MP; Plössl, K.; Skovronsky, D.; Gur, T. L.; Hou, C.; Trojanowski,
J. Q.; Lee, V. M.; Kung, H. F. Isomerization of (Z, Z) to (E, E)1-bromo-2,5-bis-(3-hydroxy carbonyl-4hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain. J. Med. Chem. 42:22702275, 2001.
106.Schmidt, ML, Schuck T, Sheridan S, Kung MP, Zhuang ZP, Bergeron C, Lamarche JS, Skovronsky
D, Giasson BI, Lee VMY and Trojanowski JQ. The fluorescent Congo Red Derivative, (Trans, Trans)1-Bromo-2,5-Bis-(3-Hydroxycarbony-4-Hydroxy)Styrylbenzene (BSB), labels Diverse b-Pleated Sheet
Structures in Postmortem Human Neurodegenerative Disease Brains. Am J. Pathol, 159, 937-943, 2001.
107.Efange S, Tu Z, von Hohenberg K, Francesconi L, Howell R, Rampersad M, Todaro L, Papke R,
Kung MP. 2-(2-Piperidyl)- and 2-(2-Pyrrolidyl)- chromans as Nicotine Agonists: Synthesis and
Preliminary Pharmacological Characterization. J Med Chem 44: 4704-4715, 2001.
108. Zhuang ZP, Kung MP, Hou C, Plössl K, Skovronsky D, Gur T, Trojanowski J, Lee, VM-Y, Kung
HF. IBOX(2-(4’-dimethyl-aminophenyl)-6-iodobenzoxazole):a ligand for imaging amyloid plaques in
the brain. Nucl Med Bio 28: 887-894, 2001
109. Kung HF, Lee CW, Zhuang ZP, Kung MP, Hou C, Plössl K. Novel stilbenes as probes for amyloid
plaques. J Am Chem Soc, 123: 12740-12741, 2001.
110. Kung MP, Hou C, Zhuang ZP, Zhang B, Skovronsky D, Gur T, Trojanowski J, Lee, VM-Y, Kung
HF. IMPY: An improved thioflavin-T derivative for in vivo Labeling of -amyloid plaques. Brain
Research, 956:202-210, 2002.
111. Ono M, Kung MP, Hou C, Kung HF. Benzofuran derivatives as Aß-aggregate-specific imaging
agents for Alzheimer’s disease. Nucl Med Biol. 29: 633-642, 2002.
112. Kung MP, Hou C, Zhuang ZP, Skovronsky D, Zhang B, Gur TL, Trojanowski JQ, Lee VMY, Kung
HF. Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque
detection in Alzheimer’s disease. J Mol Neurosci 19: 7-10, 2002.
113. Kung MP, Skovronsky D, Hou C, Zhuang ZP, Gur T, Zhang B, Trojanowski J, Lee VM-Y, Kung
HF. Detection of amyloid plaques by radioligands for Aß40 and Aß42: potential imaging agents in
Alzheimer’s patients. J Mol Nuerosci, 20: 15-23, 2003.
114. Zhuang ZP, Kung MP, Wilson A, Lee CW, Plössl K, Hou C, Holtzman DM, Kung HF. Structureactivity relationship of imidazo [1,2-a] pyridines as ligands for detecting ß-amyloid plaques in the brain.
J Med Chem, 46: 237-243, 2003.
115. Lee CW, Kung MP, Hou C, Kung HF. Dimethylamino-fluorenes: ligands for detecting ß-amyloid
plaques in the brain. Nucl Med Biol, 30: 573-580, 2003.
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116. Ono M, Wilson A, Nobrega J, Westaway D, Verhoeff P, Zhuang ZP, Kung MP, Kung HF. 11Clabeled stilbene derivates as Aß-aggregate-specific PET imaging agents for Alzheimer’s disease. Nucl
Med Biol, 30: 565-571, 2003.
117. Kung MP, Zhuang ZP, Hou C, Jin LW, Kung HF. Characterization of radioiodinated ligand
binding to amyloid beta plaques. J Mol Nuerosci, 20:249-254, 2003.
118. Crystal AS, Giasson BI, Crowe A, Kung MP, Zhuang ZP, Trojanowki JQ, Lee VMY. A
comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J Neurochem 86:
1359-1368, 2003.
119. Kung HF, Kung MP, Zhuang ZP, Hou C, Lee CW, Plössl K, Zhuang B, Skovronsky DM, Lee V,
Trojanowski JQ. Iodinated tracers for imaging amyloid plaques in the brain. Molec Imag Biol,5: 418426, 2003.
120. Cai L, Chin FT, Pike VW, Toyama H, Liow JS, Zoghbi SS, Modell K, Briard E, Shetty HU,
Sinclari K, Donohue S, Tipre D, Kung MP, Dagostin C, Widdoson DA, Green M, Hao W, Herman
MM, Ishise M and Innis RB. Synthesis and Evaluation of Two 18F-Labeled 6-Iodo-2-(4'-N,Ndimethylamino)phenylimidazo[1,2-a]pyridine Derivatives as Prospective Radioligands for -Amyloid in
Alzheimer's Disease. J Med Chem 47:2208-2218, 2004
121. Kung MP, Hou C, Zhuang ZP, Cross AJ, Maier DL, Kung HF. Characterization of IMPY as a
potential imaging agent for ß-amyloid plaques in double transgenic PSAPP mice. Eur J Nucl Med and
Molec Imag, 31, 1136-1145,2004.
122. Kung MP, Choi SR, Hou C, Zhuang ZP, Foulon C, Kung HF. Selective binding if 2-[125 I]iodonisoxetine to norepinephrine transporters in the brain. Nucl Med Biol, 31: 533-541, 2004.
123.Kung MP, Hou C, Zhuang ZP, Skovronsky D, Kung HF. Binding Of Two Potential Imaging Agents
Targeting Amyloid Plaques In Postmortem Brain Tissues Of Patients With Alzheimer's Disease. Brain
Res, 1025: 89-105, 2004.
124.Verhoeff NPLG, Wilson AA, Takeshita S, Trop L, Hussey D, Singh K, Kung HF, Kung MP, Houle
S. In vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET. Am J Geriatr Psychiatry
12: 584-595, 2004.
125.Zhuang ZP, Kung MP, Hou C, Plössl K, Kung HF. Biphenyls labeled with 99mTc for imaging Aß
plaques in the brain. Nucl Med Bio, 32,171-184, 2005
126.Ono M, Haratake M, Nakayama M, Kaneko Y, Kawabata K, Mori H, Kung MP and Kung HF,
Synthesis and Biological Evaluation of (E)-3-Styrylpyridine Derivatives as Amyloid Imaging Agents for
Alzheimer’s Disease. Nucl Med Biol.32,329-335, 2005.
127. Zhang W, Oya S, Kung MP, Hou C, Maier DL and Kung HF, F-18 stilbenes as PET imaging
agents for Detecting -Amyloid Plaques in the Brain. J. Med. Chem. 48, 5980-5988, 2005.
128.Kung MP and Kung HF. Mass effect of injected dose in small rodent imaging by SPECT and PET.
Nucl Med Biol. 32, 673-678, 2005.
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129.Zhang W, Oya S, Kung MP, Hou C, Maier DL and Kung HF, F-18 Polyethyleneglycol stilbenes as
PET imaging agents targeting Aaggregates in the brain. Nucl Med Biol, 32, 799-809, 2005.
130.Chandra R, Kung MP and Kung HF. Design, synthesis and structure-activity relationship of novel
thiophene derivatives for -amyloid plaque imaging. Bioorg & Med Chem Letters,16, 1350-1352, 2006.
131.Hou C, Tu Z, Mach R, Kung HF and Kung MP. Characterization of a novel iodinated sigma-2
receptor ligand as a cell proliferation marker. Nucl Med Biol, 33:203-209,2006.
132.Zhuang, ZP, Kung, MP and Kung HF. Synthesis of Biphenyltrienes as Probes for b-Amyloid
Plaques. J. Med. Chem. 49:2841-2844, 2006 .
133.Ono, M, Kawashima H, Nonaka A, Kawai T, Haratake M, Mori H, Kung MP, Kung HF, Saji H,
Nakayama M. Novel Benzofuran Derivatives for PET Imaging of -Amyloid Plaques in Alzheimer's
Disease Brains. J. Med. Chem. 49:2725-2750, 2006.
134.Newberg AB, Wintering NA, Plössl K, Hochold J, Stabin MG, Watson M, Skovronsky D, Clark
CM, Kung MP, Kung HF. Safety, Biodistribution, and Dosimetry of 123I-IMPY: A Novel Amyloid
Plaque–Imaging Agent for the Diagnosis of Alzheimer's Disease. J Nucl Med 47:748-754, 2006.
135.Goswami, R, Ponde DE, Kung MP, Hou C, Kilbourn, MR, Kung HF. Fluoroalkyl derivatives of
dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine
transporters. Nucl Med Biol 33:685-694, 2006.
136.Zhang W, Kung MP, Oya S, Hou C, Kung HF. F-18 labeled styrylpyridines as PET agents for
amyloid plaque imaging. Nucl Med Biol 34:89-97, 2007.
137.Stephenson KS, Chandra R, Zhuang Z-P, Hou C, Oya S, Kung MP, Kung HF., Fluoro-pegylated
(FPEG) imaging agents Targeting Aβ aggregates. Biocongugate Chem, 18:238-46, 2007.
138. Kung MP, Hou C, Goswami, R, Ponde DE, Kilbourn, MR, Kung HF. Characterization of optically
resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET Imaging agent targeting vesicular
monoamine transporters. Nucl Med Bio. 34, 239-246, 2007.
139.Oya S, Choi SR, Kung MP, Kung HF., 5-Chloro-2-(2’-((dimethylamino)methyl)-4’iodophenylthio)benzenamine: A new serotonin transporter ligand. Nucl Med Biol. 34, 129-139, 2007
140.Kilbourn MR, Hockley B, Lee LS, Hou C, Goswami R, Ponde DE, Kung MP, and Kung HF.,
Pharmacokinetics of [18F]Fluoroalkyl Derivatives of Dihydrotetrabenazine in Rat and Monkey Brain.
Nucl Med. 34, 23-237, 2007.
141. Qu W, Kung MP, Hou C, Benedum TE and Kung HF., Novel Styrylpyridines as Probes for
SPECT Imaging of Amyloid . J. Med. Chem, 50, 2157-2165, 2007.
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142.Chandra R, Oya S, Kung MP, Hou C, Jin LW and Kung HF., New diphenylacetylene as probes for
postiron emission tomographic imaging of amyloid plaques. J. Med. Chem, 50, 2415-2423, 2007.
143. Qu W, Kung MP, Hou C, Oya S and Kung HF., Quick assembly of 1,4-diphenyltriazoles as Probes
targeting -Amyloid aggregates in Alzhemier’s disease. J. Med. Chem, 50, 3380-3387, 2007.
144. Parhi AK, Wang JL, Oya S, Choi SR, Kung MP and Kung HF., 2-(2’-((Dimethylamino)methyl)4’-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents. J
Med.Chem, 50, 6673-6684, 2007.
145. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, LaFerla
FM and Jin LW., High affinity congo red and thioflavin –T analogs detect A oligomers.
J. Neurochemistry, 104, 457-468, 2008.
146. Lakshmi B, Kung MP, Lieberman B, Zhao J, Waterhouse R and Kung HF., (R)-N-Methyl-3-(3125I-pyridin-2-yloxy)-3-phenylpropan-1-amine ([125I]PYINXT): a novel probe for norepinephrine
transporters (NET). Nucl Med Biol, 35, 35-42, 2008.
147.Ploessl K, Chandra R, Qu W, Lieberman BP, Kung MP, Zhou R, Huang B and Kung HF., A novel
gallium bisaminothiolate complex as a jmyocardial perfusion imaging agent. Nucl Med Biol, 35, 83-90,
2008.
148. Song PJ, Bernard S, Sarradin P, Vergote J, Barc C, Chalon S, Kung MP, Kung HF and Guilloteau
D., IMPY, a potential b-amyloid imaging probe for detection of prion deposits in scrapie-infected mice.
Nucl Med Biol, 35, 197-201, 2008.
149.Kung MP, Hou C, Lieberman BP, Ponde DE, Goswami R, Blankemeyer E, Skovronsky D, Deng S,
Markmann JS, Kilbourn MR and Kung HF., In Vivo Imaging of Beta Cell Mass in Rats using [ 18F]FP(+)-DTBZ: A potential PET ligand for studying diabetes mellitus, J. Nucl. Med. 49, 1171-1176,2008.
150.Wang JL, Parhi AK, Oya S, Liberman BP, Kung MP and Kung HF., 2-(2’((Dimethylamino)methyl)-4’-(3-[18F]fluoropropozy)-phenylthio)benzenamine for positron emission
tomography imaging of serotonin transporters. Nucl Med Biol, 35, 447-458, 2008.
151.Kung HF, Liberman BP, Zhuang ZP, Oya S, Kung MP, Choi SR, Blankemeyer E, Hou C,
Skovronsky D and Kilrourn MR., In vivo imaging of vesicular monoamine transporter 2 in pancreas
using an 18F epoxide derivative of tetrabenazine. Nucl Med Biol, 35, 825-837, 2008.
152. Parhi AK, Kung MP, Ploessl K, Kung HF., Synthesis of fluorscent probes based on stilbenes and
diphenylacetylenes targeting beta-amyloid plaques. Tetrahedron lett. 49, 3395-3399,2008.
153. Qu W, Choi SR, Hou C, Zhuang Z, Oya S, Zang W, Kung MP,Manchandra R, Skovronsky DM,
Kung HF., Synthesis and evaluation of indolinyl-and indolyphenylacetylenes as PET imaging agents for
beta-amyloid plaques. Bioorg Med Chem Lett. 18,4823-7,2008.
154. Rowe CC, Ackerman U, Browne W, Mulligan R, Pike KL, O’keefe G, Tochon-Danguy H, Chan G,
Berlangieri SU, Jones G, Dickinson-Rowe KL, Kung HF, Zhang W, Kung MP, Skovronsky D, Kyrks T,
Holl G, Krause S, Friebe M, Lehman L, Lindemann S, Dinkelborg LM, Masters CL, Villemagne VL.,
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Imaging of amyloid beta in Alzheimer’s disease with 18F-BAY94-9172, a novel PET tracer: proof of
mechsnism. Lancet Neurol. 7, 129-135, 2008.
155.Wey SP, Weng CC, Lin KJ, Yao CH, Yen TC, Kung HF, Skovronsky D and Kung MP, Validation
of a 18F-labeled biphenylalkyne as a PET imaging agent for -amyloid plaques. Nucl. Med. Biol.36,
411-417, 2009.
156. Qu W,Ploessl K, Truong H, Kung MP and Kung HF, Iodophenyl tagged sphingosine derivatives;
Synthesis and preliminary biological evaluation. Bio. Med. Chem. Let. 19, 3382-3385, 2009.
157. Lin KJ, Hsu WC, Hsiao IT, Wey SP, Jin LW, Skovronsky D, Wai YY, Chang HP, Lo CW, Yao
CH, Yen TC, Kung MP, Whole-body biodistritution and brain PET imaging with [18F]AV-45, a novel
amyloid imaging agent---a pilot study. Nucl. Med. Biol. 37, 497-508, 2010.
158.Tsao HH, Lin KJ, Juang JH, Skovronsky DM, Yen TC, Wey SP, Kung MP. Binding characteristics
of 9-fluoropropyl-(+)-dihydrotetrabenzazine (AV-133) to the vesicular monoamine transporter type 2 in
rats. Nucl Med Biol. 37, 413-9, 2010
159. Lin KJ, Weng YH, Wey SP. Hsiao IT, Lu CS, Skovronsky, DM, Chang HP, Kung MP and Yen
TC.,Whole-body Biodistribution and Radiation dosimetry of 18F-FD-(+)DTBZ (18F-AV-133)- a Novel
Vesicular Monoamine Transporter 2 imaging Agent. J Nul. Med. In press.
Book Chapters, Monographs and Conference Proceedings
1.
Cheng YC, Hoffman PJ, Kung MP. Presence of antibody against herpes simplex virus-specified
thymidine kinase and deoxyribonuclease in human sera. Oncogenesis and Herpes Viruses III,
Part 2, de The G, Henle W, Rapp F, eds. pp. 899-904, 1978.
2.
Kung HF, Ohmomo Y, Kung MP. Current and future radiopharmaceuticals for brain imaging
with single photon emission computed tomography (review). Seminars In Nuclear Medicine
20(4):290-302, 1990.
3.
Kung HF, Bradshaw JE, Chumpradit S, Zhuang ZP, Kung MP, Mu M and Frederick D. New
TcO(III) and ReO(III) N2S2 complexes as potential CNS 5-HT1A receptor imaging agents.
Proceedings of the Fourth International Symposium on Technetium in Chemistry and Nuclear
Medicine, Bressanone, Italy, September 12-14, 1994.
4.
Kung HF, Meegalla S, Plössl K, Kung MP, Mu M. Two Tc-99m N2S2 complexes as dopamine
transporter imaging agents. Technetium, Rhenium and Other Metals in Chemistry and Nuclear
Medicine, Nicolini M and Mazzi U, eds. (Vol 5). Servizi Grafici Editoriali, Padova, Italy, 1999,
pp. 373-379.
5.
Chumpradit S, Kung MP, Mu M, Kung HF. Design and synthesis of 99mTc-labeled benzamides
as potential dopamine D2/D3 receptor imaging agents. Technetium, Rhenium and Other Metals
in Chemistry and Nuclear Medicine, Nicolini M and Mazzi U, eds. (Vol 5). Servizi Grafici
Editoriali, Padova, Italy, 1999, pp. 497-502
Patents
14
15
1.
WO2008131148-A1
Title: New diphenyl-heteroaryl derivatives useful for producing diagnostic composition for
imaging amyloid deposits and for treating neurodegenerative disorders
Assignee: UNIV PENNSYLVANIA
Inventor(s): KUNG H F, KUNG M, QU W
Citing Patents: 0
Full Text
2.
2008-M63458
WO2008073350-A2; US2008166299-A1; WO2008073350-A3
Title: New acetylene compounds are amyloid plaque aggregation inhibitors useful for imaging
amyloid deposits
Assignee: UNIV PENNSYLVANIA
Inventor(s): KUNG H F, KUNG M P
Citing Patents: 0
Full Text
3.
2008-M61871
US2008253967-A1; WO2008128129-A1
Title: New styrylpyridine derivatives useful in diagnostic compositions for imaging amyloid
deposits present in e.g. Alzheimer's disease, Mediterranean fever, Muckle-Wells
syndrome, idiopathic myeloma, amyloid polyneuropathy
Assignee: KUNG H F, KUNG M P, MANCHANDA R, et. al
Inventor(s): KUNG H F, KUNG M P, MANCHANDA R, et. al
Citing Patents: 0
Full Text
4.
2008-M32056
WO2007126733-A2; US2008038195-A1; WO2007126733-A3; ...
Title: New styrylpyridine derivative for preparation of a pharmaceutical composition, and a
diagnostic composition for imaging amyloid deposits; and for inhibiting amyloid plaque
aggregation
Assignee: UNIV PENNSYLVANIA, KUNG H F
Inventor(s): KUNG H F, KUNG M P
Citing Patents: 1
Full Text
5.
2008-H42835
US2007254889-A1
Title: Pharmaceutical composition useful for treating Alzheimer's disease comprises
compounds selected from substituted phenyl, fluorene or biphenyl derivatives
Assignee: JIN L, KUNG H F, KUNG M
Inventor(s): JIN L, KUNG H F, KUNG M
Citing Patents: 0
Full Text
6.
2008-A78058
WO2007130365-A2; US2008050312-A1; WO2007130365-A3; ...
15
16
Title: New radiolabeled dihydrotetrabenazine derivatives useful in diagnostic composition for
imaging vesicular monoamine transporters
Assignee: UNIV PENNSYLVANIA, UNIV MICHIGAN, AVID RADIOPHARMACEUTICALS INC,
et. al
Inventor(s): KUNG H F, KUNG M, KILBOURN M, et. al
Citing Patents: 0
Full Text
7.
2006-539185
WO2006078384-A2; US2006269474-A1; EP1838298-A2
Title: New stilbene derivatives are amyloid plaque aggregate inhibitors, useful as a diagnostic
composition and for imaging amyloid deposits
Assignee: UNIV PENNSYLVANIA
Inventor(s): KUNG H F, KUNG M, ZHUANG Z
Citing Patents: 4
Full Text
8.
2006-446369
WO2006066104-A2; US2006269473-A1; NO200703650-A; ...
Title: New halo-labeled or unlabeled stilbene derivatives useful in diagnostic composition for
imaging amyloid deposits or in pharmaceutical composition for treating e.g. Alzheimer's
disease
Assignee: UNIV PENNSYLVANIA, UNIV ILLINOIS FOUND
Inventor(s): KUNG H F, KUNG M, ZHUANG Z, et. al
Citing Patents: 3
Full Text
9.
2004-348142
WO2004032975-A2; AU2003277280-A1; EP1553985-A2; ...
Title: New biphenyl, fluorene and pyrazole derivatives useful for imaging amyloid deposits in
Alzheimer's disease
Assignee: KUNG H F, KUNG M P, ZHUANG Z, et. al
Inventor(s): KUNG H F, KUNG M P, ZHUANG Z, et. al
Citing Patents: 1
10.
2003-300666
WO2003018070-A; WO2003018070-A1; US2003149250-A1; ...
Title: New stilbene derivatives, useful for imaging of amyloid deposits and for inhibiting amyloid
plaque aggregation
Assignee: UNIV PENNSYLVANIA, KUNG H F, KUNG M, et. al
Inventor(s): KUNG H F, KUNG M, ZHUANG Z, et. al
Citing Patents: 8
11.
2003-058710
WO200285903-A; WO200285903-A2; US2003059369-A1; ...
Title: Novel aminophenyl-imidazopyridine derivatives for imaging and reduction of amyloid
deposits
Assignee: KUNG H, KUNG M, ZHUANG Z, et. al
Inventor(s): KUNG H, KUNG M, ZHUANG Z, et. al
Citing Patents: 10
16
17
12.
1999-527339
WO9940882-A; WO9940882-A2; AU9940678-A
Title: New diaminethiol ligands useful in the preparation of complexes
Assignee: UNIV PENNSYLVANIA
Inventor(s): KUNG H F, KUNG M, ZHUANG Z
Citing Patents: 0
13.
1997-244869
WO9714445-A; EP929319-A; WO9714445-A1; ...
Title: New tropane-based derivatives bind selectively to central nervous system receptors useful in diagnostic methods for monitoring neuronal functions in mammals, particularly
in single photon emission computed tomography
Assignee: UNIV PENNSYLVANIA
Inventor(s): KUNG H F, MEEGALLA S, KUNG M, et. al
Citing Patents: 13
14.
1995-319484
US5446147-A
Title: New dopamine D1 or D2 imaging agents - are benzamide or phenyl deriv's labelled with
fluorine or iodine, used in PET and SPECT imaging
Assignee: UNIV PENNSYLVANIA
Inventor(s): KUNG H F, CHUMPRADIT S, KUNG M P
Citing Patents: 3
17