Swine Anesthesia and Analgesia Formulary Effective Date: November 2015 Note that all of these doses are approximations and must be titrated to the animal’s strain, age, sex and individual responses. Significant departures from these doses should be discussed with a veterinarian. Doses will also vary depending on what other drugs are being administered concurrently. All doses are listed as milligrams per kilogram (mg/kg) unless otherwise noted. Drug name Dose (mg/kg) & Route Frequency Notes Inhalation anesthetics – Must use precision vaporizer. Survival surgery requires concurrent preemptive analgesia. Recommended: 1-3% inhalant to Whenever Mask induction is possible with effect (up to 5% general pre-sedated pigs. Survival Isoflurane or Sevoflurane for induction). anesthesia is surgery requires concurrent preUp to 8% for required emptive analgesia. Sevoflurane Injectable anesthetics and tranquilizers Ketamine-Acepromazine 33 + For sedation Can result in large volumes 1.1 IM, SC and pre(in same anesthesia syringe) 4 – 8 IM For sedation Note that Telazol® must be Recommended: or prestored refrigerated once Telazol® alone (a combination anesthesia reconstituted. of tiletamine and zolazepam – when reconstituted with 5 ml sterile water, a vial contains 50 mg/ml of each drug. Dose listed is based on 100mg/ml of combined active ingredients) Midazolam 0.1 – 0.5 IM or May be used Usually only used for minor SC for sedation procedures to provide mild when needed sedation in conjunction with at frequent Isoflurane intervals Opioid analgesia – 0.01 – 0.05 SC Used preFor major procedures, require Recommended: operatively for more frequent dosing than 12 Buprenorphine preemptive hour intervals. Consider multianalgesia and modal analgesia with a NSAID Sustained Release Buprenorphine 0.1 – 0.5 SC Recommended: Carprofen 2 – 4 SC or PO postoperatively every 6-12 hour Used for long term analgesia. Approx.72 hour duration and a local anesthetic For major procedures, requiring more frequent dosing than 12 hour intervals. Consider multimodal analgesia with a NSAID and local Used preDepending on the procedure, operatively for may be used as sole analgesic, preemptive or as multi-modal analgesia with analgesia and buprenorphine. postoperatively every 24 hour for up to 4 days. Local anesthetic/analgesics (lidocaine and bupivacaine may be combined in one syringe or used separately) Lidocaine hydrochloride 4 mg/kg Use locally Faster onset than bupivacaine Dilute to 0.5 before making but short (<1 hour) duration of 1% (=10mg/ml). surgical action May be mixed incision or as in same syringe “splash block” with at closure bupivacaine. SC or intraincisional Bupivacaine Dilute to 0.25 – Use locally Slower onset than lidocaine but 0.5%, May be before making longer (~ 4-8 hour) duration of mixed in same surgical action syringe with incision or as lidocaine. “splash block” SC or intraat closure incisional