Cardiology
CONSENSUS Trial – The effects of Enalapril on Mortality in Severe Congestive Heart Failure(CONSENSU).
NEJM June 4, 1987. Vol 316. Pg 1429-35.
COURAGE Trial – Optimal Medical Therapy with or without PCI for Stable Coronary Artery Disease.
NEJM April 12, 2007. Vol 356. No 15. Pg 1503-16.
GISSI-3 Trial – Effects of Lisinopril and transdermal glycerly trinitrate singly and together on 6-week
mortality and ventricular function after Acute Myocardial Infarction. Lancet 1994. Vol 343. Pg 1115-22.
ISIS-2 – Randomized Trial of Streptokinase, oral Aspirin, both, or neither among 17187 cases of
suspected Acute Myocardial Infarction. Lancet Aug 13, 1988. Pg 349 – 360.
ISIS-4 – Randomized factorial trial assessing early oral captopril, oral mononitrate, and IV magnesium in
58,050 patients with suspected Acute Myocardial Infarction. Lancet 1995. Vol 345. Pg 669-85.
MERIT-HF – Effect of Metoprolol CR/XL in Chronic Heart Failure. Lancet 1999. Vol 353. Pg 2001-7.
MRFIT – Is relationship between serum Cholesterol and risk of premature death from Coronary Heart
Disease continuous and graded? JAMA 1986. Vol 256. No. 20. Pg 2823-28.
RALES – The Effect of Spirnolactone on Morbidity and Mortality in patients with Severe Heart Failure.
NEJM 1999. Vol 341. No 10. Pg 709-717.
4S – Randomized trial of cholesterol lowering in 4444 patients with Coronary Artery Disease –
Scandanavian Simvastatin Survival Study. Lancet 1994. Vol 344. Pg 1383-89.
SCD-HeFT – Amiodarone or ICD for Congestive Heart Failure. NEJM January 20, 2005. Vol 352. No 3. Pg
225-237.
SHEP – Prevention of Stroke by Antihypertensives in Older Persons with isolated systolic hypertension.
Systolic Hypertension in the Elderly Program. JAMA June 26, 1991. Vol 265. No 24. Pg 3255-64.
SOLVD – Effect of Enalapril on Survival in patients with Reduced LV EF and Congestive Heart Failure.
NEJM August 1, 1991. Vol 325. No 5. Pg 293-302.
AFFIRM – A comparison of rate control and rhythm control in patients with atrial fibrillation. NEJM
December 5, 2002. Vol 347. No 23. Pg 1825-33.
ALLHAT – A comparison of outcomes with ACEi and diuretics for hypertension in the elderly. NEJM
February 13, 2003. Vol 348. No 7. Pg 583-92.
Aspirin, heparin or both to treat acute unstable angina. NEJM Oct 27, 1988. Vol 319. No 17. Pg 110511.
Rheumatology
A controlled trial of arthroscopic surgery for osteoarthritis of the knee. NEJM July 11, 2002. Vol 347.
No 2. Pg 81-88.
Diabetes
DCCT - The effect of intensive treatment of diabetes on the development of long term complications in
insulin dependent diabetes mellitus. NEJM Sept 30, 1993.
DCCT 2005 – Intensive diabetes treatment and cardiovascular disease in patients with type I diabetes.
NEJM Dec 22, 2005. Vol 353. No 25. Pg 2643-53.
The effect of ACEi on diabetic nephropathy. NEJM Nov. 11, 1993. Vol 329. Pg 1456.
MRC/NHF Heart Protection Study of simvastatin in 5963 with diabetes. Lancet 2003. Vol 361. Pg 20052016.
UKPDS – Intensive glucose control with sulfonylureas or insulin compared with conventional treatment
and risk of complications in patients with type II diabetes. Lancet Sept 12, 1998. Vol 352. Pg 837-53.
ACCORD – Effects of intensive glucose lowering in type II diabetes. NEJM June 12, 2008. Vol 358. Pg
2545-2559.
ADVANCE – Intensive blood glucose control and vascular outcomes in patients with type II diabetes.
NEJM 2008. Vol 358. Pg 2560-72.
Infectious Disease
Effectiveness of pneumococcal polysaccharide vaccine in older adults. NEJM 2003. Vol 348. Pg 174755.
PORT Score. A prediction rule to identify low risk patients with community acquired pneumonia. NEJM
1997. Vol 336. Pg 243-50.
Neurology
European Stroke Prevention Study II – Dipyridamole and acetylsalicylic acid in the secondary prevention
of stroke. Journal of the Neurological Sciences. 1996. Vol 143. Pg 1-13.
NASCENT - Beneficial effect of carotid endarterectomy in symptomatic patients with high grade carotid
stenosis. NEJM 1991. Vol 325. Pg 505-507.
Stroke prevention in atrial fibrillation study. Circulation 1991. Vol 84. Pg 527-39.
Oncology
Prevention of colorectal cancer by colonoscopic polypectomy. NEJM Dec 30, 1993. Vol 329. No 27. Pg
1977-81.
Geriatrics
HORIZON – Once yearly zoledronic acid for treatment of post menopausal osteoporosis. NEJM. May 3,
2007. Vol 356. No 18. Pg 1809-22.
Effect of Alendronate on risk of fracture in women with low bone density but without vertebral
fractures. JAMA 1998. Vol 280. No 27. Pg 2077-2082.
Pulmonary/Critical Care
Efficacy of Varenicline vs. placebo or sustained-release bupropion for smoking cessation. JAMA July 5,
2006. Vol 296. No. 1. Pg 56-63.
ISOLDE – Randomized, double blind placebo controlled study of fluticasone in patients with moderate to
severe COPD. BMJ. May 13, 2000.
Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive
pulmonary disease: a prospective randomized controlled trial. Lancet 1999. Vol 354. Aug 7. 1999. Pg
456-460.
Prevention of Exacerbation of COPD with tiotropium. Annals of Internal Medicine 2005. Vol 143. Pg
317-26.
TORCH – Salmeterol and fluticasone and survival in COPD. NEJM 2007. Vol 356. No 8. Pg 775-89.
TRISTAN – Combined salmeterol and fluticasone in the treatment of COPD. Lancet 2003. Vol 361. Pg
449-456.
PROWESS – Efficacy and safety of recombinant human activated protein C for severe sepsis. NEJM
March 8, 2001. Vol 344. No 10. Pg 699-709.