NIH-T35 Medical Student Training Grant in Renal, GI, Endocrine & Epithelial Biology Principal Investigator: Thomas Kleyman, MD Participating Faculty Members (Alphabetically by Faculty Member) Name/Degree(s) Rank Albers, Kathryn, PhD Professor Primary (& Secondary) Appointment (s) Email Research Interest Department of Medicine Division of Gastroenterology, Hepatology, and Nutrition kaa2@pitt.edu Sensory neurons, neurotrophic factors & transcription factors Alonso, Laura, MD Assistant Professor Department of Medicine, Division of Endocrinology and Metabolism alonsolc@upmc.edu Beta cell regeneration Apodaca, Gerard, PhD Professor Dept of Medicine (Cell Biology & Physiology, Bioengineering) gla6@pitt.edu Membrane trafficking mechanisms in specialized epithelia Aridor, Meir, PhD Associate Professor Cell Biology & Molecular Physiology aridor@pitt.edu Membrane traffic of proteins and lipids Billiar, Timothy Professor Department of Surgery billiartr@upmc.edu Shock, injury, inflammation Birder, Lori, PhD Associate Professor Department of Medicine (Pharmacology & Chemical Biology) lbirder@pitt.edu Epithelial cell function in the urinary bladder Brodsky, Jeff, PhD Professor Department of Biological Sciences jbrodsky@pitt.edu ER associated protein degradation (ERAD) Departments of Medicine, Surgery and Immunology butterfieldl@upmc.edu Professor Tumor immunology, melanoma, hepatocellular cancer Assistant Professor Department of Medicine (and Immunology), Renal Electrolyte Division chalasanig2@upmc.edu B cells and memory T cells in the pathogenesis of allograft rejection Butterfield, Lisa, PhD Assistant Chalasani, Geetha, MD Name/Degree(s) Rank DeFranco, Donald, PhD Professor Department of Pharmacology & Chemical Biology, Neuroscience dod1@pitt.edu Signal transduction and neurodegeneration Duerr, Richard, MD Associate Professor Department of Medicine and Human Genetics Head, Inflammatory Bowel Disease Genetics Program duerrh@upmc.edu Inflammatory bowel disease genetics Ferrell, Robert, PhD Professor Department of Human Genetics rferrell@helix.hgen.pitt.edu Disease susceptibility population genetics. Fox, Ira Professor Department of Surgery & Transplantation ira.fox@chp.edu Hepatocyte transplantation; Generation of human-induced pluripotent stem cells Fried, Linda, MD, MPH Associate Professor Department of Medicine and Epidemiology friedlf2@upmc.edu Chronic kidney disease, Peritoneal dialysis, cardiovascular disease, diabetic nephropathy Department of Pharmacology, Department of Medicine (Renal Division) paf10@pitt.edu Regulation of parathyroid hormone receptor signaling and regulated trafficking Friedman, Peter, PhD Professor Primary (& Secondary) Appointment (s) Email Research Interest 2 Name/Degree(s) Rank Primary (& Secondary) Appointment (s) Email Research Interest Frizzell, Raymond, PhD Professor and Chairman Department of Cell Biology and Physiology frizzell@pitt.edu Basic studies of the function, protein interactions, trafficking and processing of the CF gene product, CFTR; understanding the infectioninflammation issues that compromise the function of CF airways Garcia-Ocana, Adolfo, PhD Associate Professor Department of Medicine, Division of Endocrinology and Metabolism ocana@pitt.edu Use of growth factors and intracellular signaling molecules to improve islet transplantation Greenspan, Susan, MD Professor Department of Medicine, Division of Endocrinology and Metabolism greenspansl3@upmc.edu Combination therapy for treatment of osteoporosis Hackam, David, MD, PhD Associate Professor Department of Pediatric Surgery, Cell Biology and Physiology david.hackam@chp.edu Regulation of intestinal inflammation by innate immune receptors Hallows, Kenneth, MD, PhD Assistant Professor Department of Medicine, Cell Biology & Physiology hallows@pitt.edu Cystic fibrosis transmembrane conductance regulator Epithelial Na+ channel 3 Name/Degree(s) Rank Hughey, Rebecca, PhD Associate Professor Department of Medicine, Department of Cell Biology and Physiology, Department of Microbiology and Molecular Genetics hughey@dom.pitt.edu Apical membrane trafficking in polarized epithelia, and regulation of epithelial sodium channel (ENaC) Hukriede, Neil, PhD Assistant Professor Department of Microbiology and Molecular Genetics hukriede@pitt.edu Origin and regulation of kidney progenitor cells Humphrey, Allen, PhD Associate Professor Department of Neurobiology humphrey@pitt.edu T35 training grant codirector Department of Pharmacology and Medicine edj@pitt.edu Pre-clinical cardiovascular & renal pharmacology Jackson, Edwin, PhD Professor Primary (& Secondary) Appointment (s) Email Research Interest Johnson, John, MD Professor Department of Medicine, Renal Eletrolyte Division, Department of Cell Biology and Physiology johnsonjp@upmc.edu Cellular regulating mechanisms and epithelial sodium channel trafficking Kleyman, Thomas, MD Professor Department of Medicine (Cell Biology and Physiology) kleyman@pitt.edu Structure, function, & regulation of epithelial Na+ & K+ channels Korytkowski, Mary, MD Professor Department of Medicine, Division of Endocrinology korytkowskim@upmc.edu Inpatient diabetes education Lakkis, Fadi, MD Professor Departments of Surgery and Immunology lakkisf@upmc.edu The biology of memory T cells in organ transplantation Liu, Youhua, PhD Professor Department of Pathology, Division of Experimental Pathology yhliu@pitt.edu Cellular and molecular pathways leading to chronic renal fibrosis Lotze, Michael, MD Professor Department of Surgery and Bioengineering lotzemt@upmc.edu HMGB1 and Autophagy 4 Name/Degree(s) Rank Primary (& Secondary) Appointment (s) Email Research Interest Monga, Satdarshan, MD Associate Professor Departments of Pathology and Medicine mongss@upmc.edu Morowitz, Michael, MD Assistant Professor Department of Pediatric Surgery michael.morowitz@chp.edu Pathogenesis & Murase, Noriko, MD Associate Professor Department of Surgery murase@pitt.edu Hepatic ischemic injury Nalesnik, Michael, MD Professor Department of Pathology nalesnikma@upmc.edu Hepatic & transplant pathology Newman, Anne, MD, MPH Professor Department of Epidemiology and Medicine newmab@upmc.edu Cardiovascular disease epidemiology Orchard, Trevor, MD Professor Department of Epidemiology, Medicine and Pediatrics orchardtj@upmc.edu Diabetes and cardiovascular epidemiology Palevsky, Paul, MD Professor Department of Medicine, Renal Electrolyte Division palevskyp@upmc.edu Acute kidney injury management of chronic kidney disease Pastor-Soler, Nuria, MD, PhD Assistant Professor Department of Medicine, Renal Electrolyte Division pastorsolernm@upmc.edu Epithelial proton secretion in the kidney and male reproductive tract Department of Medicine, Cell Biology, Physiology & Pediatrics pilewskijm@upmc.edu Cystic Fibrosis and heterologous Transplantation Pilewski, Joseph, MD Associate Professor Signalling pathways in liver development, regeneration, injury & tumorigenesis mgmt of neonatal necrotizing enterocolitis 5 Name/Degree(s) Rank Primary (& Secondary) Appointment (s) Email Research Interest Reis, Steven, MD Professor Department of Medicine, Division of Cardiology reisse@upmc.edu and Emergency Medicine Pathophysiological mechanisms for atherosclerosis, racial and gender disparities in CVD, clinical and translational research Sachdev, Ulka, MD Assistant Professor Department of Surgery, Division of Vascular Surgery sachdevu2@upmc.edu Innate immunity and its role in mediating angiogenesis and muscle recovery after ischemia Scott, Donald, PhD Associate Professor Department of Medicine, Division of Endocrinology and Metabolism dks23@pitt.edu Regulation of gene expression & cellular phenotype in changing metabolic environments Thomson, Angus, PhD Distinguished Department of Surgery Professor of (Department of Immunology) Surgery thomsonaw@upmc.edu Roles of cytokines and adhesion molecules in inflammation and immunity. Traub, Linton, PhD Associate Professor Department of Cell Biology & Physiology traub@pitt.edu Membrane traffic of proteins and lipids Tsung, Allan, MD Assistant Professor Department of Surgery, Divisions of Surgical Oncology and Transplantation tsunga@upmc.edu Liver cancer; liver ischemia/reperfusion injury Vasavada, Rupangi, PhD Assistant Professor Department of Medicine, Division of Endocrinology and Metabolism vasavada@pitt.edu Therapeutic potential of growth factors in islet transplantation and beta cell regeneration 6 Name/Degree(s) Rank Email Research Interest Division of Pediatric Nephrology abhay.vats@chp.edu Genetic/biomarker studies of polyoma viruses in relation to renal transplantation Watkins, Simon, PhD Professor Department of Cell Biology and Physiology swatkins@pitt.edu Basic cell biologic processes in the immune system Weisbord, Steven, MD, MSc Assistant Professor Department of Medicine, Renal Electrolyte Division weisbordsd@upmc.edu Acute renal failure Weisz, Ora, PhD Professor Department of Medicine (Cell Biology & Physiology) weisz@pitt.edu Apical membrane traffic in polarized epithelial cells Whitcomb, David, MD, PhD Professor Department of Medicine (Gastroenterology)/ Cell Biology and Molecular Physiology Graduate Program whitdc@upmc.edu Pancreatitis, pancreatic cancer and pancreatic physiology Zhao, Allan, PhD Associate Professor Department of Cell Biology and Physiology azhao@pitt.edu Transgenic and genetargeting models to mimic the situations in human obesity and type 2 diabetes Zeh, Herbert, MD Associate Professor Department of Surgery, Division of Surgical Oncology zehxhx@upmc.edu Cancer immunobiology; damage-associated molecular pattern molecules Vats, Abhay, MD Assistant Professor Primary (& Secondary) Appointment (s) Revised 10-16-12 7