Paul LC (2000)
(reference 2)
A medical entity characterised by excessive tissue sclerosis and fibrosis,
resulting in a disruption of the renal architecture and the clinical
manifestation of deteriorated graft function.
Ponticelli C (2002) Characterised by a progressive deterioration in renal function, not related to
(reference 27)
interruption of immunosuppressant treatment, recurrence of the underlying
disease, or urological/vascular complications.
Hernández D, et
A clinical/pathological entity of multifactorial origin, characterised by vascular
al. (2006)
and tubulo-interstitial damage, and accompanied by a progressive
(reference 28)
deterioration of renal function, AHT, and proteinuria. From a histological point
of view, defined by the Banff criteria.
Djamali A, et al.
This condition is characterised by altered renal function, which develops
(2006) (reference starting in the third month following transplantation, with no identifiable
29)
cause. From a practical point of view, defined by the presence of IF/TA,
frequently accompanied by fibrointimal thickening of the vascular wall and
glomerular changes.
Serón, et al.
A clinical syndrome characterised by deteriorated renal function and IF/TA,
(2008) (reference but also other histological changes, all with an unspecified cause.
30)
Kidney Disease:
Following the recommendations of the 2005 Banff Conference, these
Improving Global guidelines advise against employing terms such as CAN and chronic rejection,
Outcomes
and instead suggest the term “chronic allograft injury/CAI”.
(KDIGO) (2009)
CAI is a diagnosis of exclusion and is characterised by a progressive
(reference 31)
deterioration in renal function, not due to recurrence of the underlying
disease or other causes. The most common histological manifestation is IF/TA,
but may include other non-specific lesions.
1