13th International Conference on Health Promoting Hospitals, “Empowering for Health: Practicing the Principles” Dublin, May 18-20, 2005 Virtual Proceedings Complex rehabilitation strategies in patients with chronic renal failure Liidia Kiisk, Ülle Pechter [1], Mai Ots [1] Centre for Physical Anthropology, 1- Department of Internal Medicine, University of Tartu, Estonia, Keywords: Medical practice, collaboration between specialists, nutrition, rehabilitation Background Chronic renal failure (CRF) represents a progressive, irreversible decline in the glomerular filtration rate (GFR). Most chronic nephropathies lack a specific treatment and progress relentlessly to end-stage renal disease which prevalence is increasing worldwide posing a large morbidity, mortality and financial burden. The need for renal replacement therapy rises ~ 7% a year [1]. The most common causes of progressive CRF are diabetic nephropathy, chronic glomerulonephritis and hypertensive nephrosclerosis [2]. A primary disease eventually leads to secondary glomerular injury and nephron loss that is clinically characterised by proteinuria, hypertension, a gradual elevation in the plasma creatinine concentration and a progressive decline in GFR [3]. Early protective measures Protective therapy may have the greatest impact if initiated early in the course of renal failure development. Good collaboration between various specialists – family physicians, nephrologists, dieticians, rehabilitation team-specialists, dialysis nurses, transplantologists is a cornerstone in health promotion strategies for patients with chronic renal failure. Family physicians play an important role in early recognising patients with potential for renal failure. Especially early intervention in patients with hypertension and diabetes is necessary. Regular blood pressure control and anti-hypertensive therapy can effectively reduce the risk for the development of kidney damage [4]. The extent to which lowering blood pressure reduces proteinuria is a possible measure for the effectiveness of therapy in slowing the progression of renal disease [5, 6]. Patients at risk merit regular renal assessment with serum creatinine tests and urine analysis for existing microalbuminuria. Population screening is even advisable [7]. The level of proteinuria must be controlled regularly in diabetic patients because it gives the most valuable hint at progression of kidney injury [8, 9]. Collaboration between specialists RAS-blocking agents are prescribed not only for anti-hypertensive but also for vasoand renoprotective purposes in diabetic nephropathy and in chronic glomerular 1 13th International Conference on Health Promoting Hospitals, “Empowering for Health: Practicing the Principles” Dublin, May 18-20, 2005 Virtual Proceedings diseases with and without systemic hypertension [10]. Because of its complexity, the integrated combined nephroprotective and cardioprotective therapy requires early and sustained guidance by a nephrologist throughout the whole CRF period [11]. Exercise therapy Aquatic environment is an ideal one for exercising for chronic renal patients. Regular, long-time provided exercising, even 2–3 times per week, produces a beneficial effect [12]. The intensity of exercise should be low, with a prolonged warm-up and exercise adaptation period and time allowance for adequate cool-down. Exercise therapy should be supervised by physiotherapist and based on comprehensive plan by a physical specialist. Nutritional management and dietician systematic review Nutritional status, body composition, anthropometrical monitoring, food intake and biochemical analysis and dietician systematic review is necessary in the complex rehabilitation. Obesity is noticed as a significant risk factor for the development of proteinuria [13]. Lowering excess weight is advisable for patients with CRF and motivation to change the dietary habits should result from education. It is shown that protein restriction slows the progression of renal disease both in clinical [14, 15] and experimental studies [16]. The catering service of Tartu University Clinic in Estonian provides food for special needs to 17 clinics with ~ 1000 patients every day. The share of diet food is about 25– 28%. The names and indications of the nomenclature of diets and the respective recommendations for consumption of daily energy and basic nutrients are given in Estonian handbook published by Liidia Kiisk, Treatment diets, Tartu, 2002 [17]. The normative values of the basic nutrients are in accordance with Estonian nutritional recommendations, the nutrition guidelines of the WHO Regional Office for Europe and with Regulation no. 131 Health Protection Requirements for Nutrition in Health Care and Social Welfare Institutions, issued on 14 November 2002 by the Estonian Minister of Social Affairs. Systematized anthropometrics Patients with CRF need to undergo nutritional assessment and their nutritional status should be followed at frequent intervals. Systematized anthropometrics should become an obligatory procedure in everyday medical practice. Lifestyle counselling 2 13th International Conference on Health Promoting Hospitals, “Empowering for Health: Practicing the Principles” Dublin, May 18-20, 2005 Virtual Proceedings Systematic lifestyle counselling and education of patients offer many potential benefits including improved treatment outcomes, reduced anxiety, greater prospect for continued employment, improved timing for the start of dialysis, and a greater opportunity for intervention to delay disease progression [18]. Various studies of the benefits of patient education programmes have shown that educated patients have a reduced incidence of emergency dialysis compared with control patients [19, 20]. Dialysis nurse as a routine part of work could make systematic assessment of quality of life with professional questionnaires for CRF patients already in the pre-dialysis state. Smoking cessation Smoking is one of the most important remediable renal risk factors. Discontinuation of smoking has been shown to improve both renal and cardiovascular prognosis in the renal patient and is probably the single most effective measure to retard progression of CRF [21]. For all the above reasons, cessation of smoking should be advised for renal patients - a recommendation, which should be given by all specialists more frequently. Patient-based management Rehabilitation of patients with CRF should encompass all aspects of the patient's well being and include vocational, physical, and medical therapies. As patients with chronic renal disease are considered in the highest risk group of premature atherosclerotic cardiovascular events, all beneficial rehabilitation strategies should be included in their management [22]. Each patient's condition should be taken into account individually when suggesting complex therapies. Careful management of the patient by healthcare professionals can retard the development of risk factors for CVD and stabilise renal functioning for a longer period of time. Acknowledgements The preparation of the manuscript was supported by scientific grants TARSK 0472 and DARCA 1880. References 1. Schieppati A, Remuzzi G, Perico N: The June 2003 Barry M. Brenner Comgan lecture. The future of renoprotection: frustration and promises Preventing end-stage renal disease: the potential impact of screening and intervention in developing countries. Kidney Int 2003;646:1947-1955. 2. Remuzzi G, Ruggenenti P, Benigni A: Understanding the nature of renal disease progression. Kidney Int 1997;511:2-15. 3. Jacobson HR: Chronic renal failure: pathophysiology. Lancet 1991;3388764:419-423. 3 13th International Conference on Health Promoting Hospitals, “Empowering for Health: Practicing the Principles” Dublin, May 18-20, 2005 Virtual Proceedings 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. Ruilope LM: The kidney as a sensor of cardiovascular risk in essential hypertension. J Am Soc Nephrol 2002;13Suppl 3:S165-168. Fournier A, Presne C, Makdassi R, Mazouz H, Choukroun G: Renoprotection with antihypertensive agents. Lancet 2002;3599318:1694-1695. Marcantoni C, Jafar TH, Oldrizzi L, Levey AS, Maschio G: The role of systemic hypertension in the progression of nondiabetic renal disease. Kidney Int Suppl 2000;75:S44-48. Briganti EM, Atkins RC, Chadban SJ: Albuminuria and renal insufficiency prevalence guides population screening. Kidney Int 2003;642:760-761. Keane WF, Lyle PA: Recent advances in management of type 2 diabetes and nephropathy: lessons from the RENAAL study. Am J Kidney Dis 2003;413 Suppl 2:S22-25. Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR: Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int 2003;631:225232. Andersen S, Rossing P, Juhl TR, Deinum J, Parving HH: Optimal dose of losartan for renoprotection in diabetic nephropathy. Nephrol Dial Transplant 2002;178:1413-1418. Avorn J, Winkelmayer WC, Bohn RL, Levin R, Glynn RJ, Levy E, Owen W, Jr.: Delayed nephrologist referral and inadequate vascular access in patients with advanced chronic kidney failure. J Clin Epidemiol 2002;557:711-716. Pechter U, Ots M, Mesikepp S, Zilmer K, Kullissaar T, Vihalemm T, Zilmer M, Maaroos J: Beneficial effects of water-based exercise in patients with chronic kidney disease. Int J Rehabil Res 2003;262:153-156. Tozawa M, Iseki K, Iseki C, Oshiro S, Ikemiya Y, Takishita S: Influence of smoking and obesity on the development of proteinuria. Kidney Int 2002;623:956-962. Locatelli F, Alberti D, Graziani G, Buccianti G, Redaelli B, Giangrande A: Prospective, randomised, multicentre trial of effect of protein restriction on progression of chronic renal insufficiency. Northern Italian Cooperative Study Group. Lancet 1991;3378753:1299-1304. Maiorca R, Brunori G, Viola BF, Zubani R, Cancarini G, Parrinello G, De Carli A: Diet or dialysis in the elderly? The DODE study: a prospective randomized multicenter trial. J Nephrol 2000;134:267-270. Abbate M, Remuzzi G: Renoprotection: Clues from knockout models of rare diseases. Kidney Int 2003;632:764-766. Kiisk L: Treatment diets. Monography 2002Tartu:Tartumaa Publisher. Bakewell AB, Higgins RM, Edmunds ME: Quality of life in peritoneal dialysis patients: Decline over time and association with clinical outcomes. Kidney Int 2002;611:239-248. Golper T: Patient education: can it maximize the success of therapy? Nephrol Dial Transplant 2001;16 Suppl 7:20-24. Binik YM, Devins GM, Barre PE, Guttmann RD, Hollomby DJ, Mandin H, Paul LC, Hons RB, Burgess ED: Live and learn: patient education delays the need to initiate renal replacement therapy in end-stage renal disease. J Nerv Ment Dis 1993;1816:371-376. 4 13th International Conference on Health Promoting Hospitals, “Empowering for Health: Practicing the Principles” Dublin, May 18-20, 2005 Virtual Proceedings 21. 22. Schiffl H, Lang SM, Fischer R: Stopping smoking slows accelerated progression of renal failure in primary renal disease. J Nephrol 2002;153:270274. Ots M, Pechter U, Tamm A: Characteristics of progressive renal disease. Clin Chim Acta 2000;2971-2:29-41. 5