Additional Table 2. Summary Table of Results for the INSIG2 variant in the literature up to March 01 2008
Given
p
value
Obesity
Assoc.
Test* p
Ref.
0.026
ND
[30]
0.027
ND
[30]
26.43
(224)
0.96
ND
[30]
ND
ND
0.008
0.008
[30]
25.38
(172)
24.89
(625)
25.17
(694)
0.06
0.06
[30]
25.50
(4.32)
25.81
(146)
25.17
(534)
25.72
(587)
0.08
0.08
[30]
26.20
(4.61)
26.79
(156)
25.90
(549)
26.31
(605)
0.003
0.003
[30]
26.83
(4.71)
27.08
(167)
26.59
(600)
27.00
(664)
0.39
0.39
[30]
27.38
(4.82)
27.65
(165)
27.31
(601)
27.38
(665)
0.48
0.48
[30]
27.82
(4.97)
28.10
(169)
27.74
(597)
27.82
(663)
0.51
0.51
[30]
Caucasian
28.74
(6.68)
29.35
(606)
28.81
(2319)
28.51
(2262)
0.006
0.006
[30]
48.70
(13.77)
Caucasian
26.91
(4.44)
26.95
(438)
26.75
(1871)
27.07
(1775)
0.44
0.44
[30]
Cohort
Disease
Sample or
exam
N
(genotyped)
MALE/FEMALE
CAMP
Asthma
families
1224
254/154
COSTA RICA
Asthma
families
1284
251/157
SCANDINDVIA
Control
Subjects from
T2D study
families
512
213/299
62.20
(10.50)
Obesity
unrelated
obese
990
364/626
46.34
(14.74)
unrelated
exam1
1491
711/780
37.05
(8.93)
unrelated
exam2
1267
608/659
44.74
(9.21)
unrelated
exam3
1310
625/685
49.20
(9.26)
unrelated
exam4
1431
681/750
52.51
(9.28)
unrelated
exam5
1431
680/751
56.12
(9.25)
unrelated
exam6
1429
683/746
60.08
(9.16)
unrelated
5187
2388/2799
54.44
(16.62)
unrelated
4084
2039/2045
ESSEN
FHS
FHS
FHS
FHS
FHS
FHS
ICELAND
KORA S3
Not selected
for a particular
trait
Not selected
for a particular
trait
Not selected
for a particular
trait
Not selected
for a particular
trait
Not selected
for a particular
trait
Not selected
for a particular
trait
Relatives of
probands with
cardiovascular
and metabolic
diseases
WHO
MONICA
(cardiovascular
disease)
project
AGE Mean
(SD)
8.74
(2.07)
9.26
(1.76)
ETHNICITY
North America
Spanish
American
Sweden and
Finland,
Caucasian
Germany,
Caucasian
Predominantly
Caucasian,
Boston area
Predominantly
Caucasian,
Boston area
Predominantly
Caucasian,
Boston area
Predominantly
Caucasian,
Boston area
Predominantly
Caucasian,
Boston area
Predominantly
Caucasian,
Boston area
17.78
(3.08)
17.77
(3.38)
Mean
BMI
C/C (N)
18.05
(49)
18.19
(28)
Mean BMI
G/C
(N)
17.97
(181)
17.46
(165)
Mean BMI
G/G
(N)
17.52
(178)
17.72
(218)
26.35
(3.43)
25.70
(57)
26.43
(211)
36.02
(5.38)
ND
25.08
(4.24)
BMI
Mean (SD)
MAYWOOD
Obesity
unrelated
893
430/463
42.96
(10.82)
African
American
28.28
(7.06)
27.47
(52)
29.23
(281)
27.83
(541)
0.68
0.68
[30]
SCANDINDVIA
Control
Subjects from
T2D study
unrelated
913
498/415
66.42
(11.91)
Caucasian
26.55
(3.63)
26.8
(96)
26.50
(396)
26.51
(393)
0.46
0.46
[30]
Germany,
Caucasian
31.82
(6.05)
31.95
(52)
31.86
(162)
31.73
(154)
0.002
ND
[4]
ESSEN
Obesity
unrelated
368
157/211
13.71
(3.08)
NURSERY
HEALTH
18% Obese,
control
samples from
T2D and
Breast Cancer
study
unrelated
2726
0/2726
55.37
(6.88)
US, Caucasian
24.89
25.96
(292)
26.11
(1208)
25.91
(1226)
>0.05
ND
[4]
US POLLAND
Cases from
several disease
groups
unrelated
1827
840/987
56.54
(8.9)
US Poland,
Caucasian
35.01
(3.36)
34.97
(213)
34.78
(820)
35.23
(794)
<0.05
ND
[4]
US POLLAND
Control group
unrelated
926
428/498
56.63
(9.42)
US Poland,
Caucasian
21.53
(0.85)
21.54
(80)
21.48
(411)
21.58
(435)
<0.05
ND
[4]
unrelated
3996
1986/2010
49.30
(13.88)
Germany,
Caucasian
26.09
27.80
(434)
27.30
(1829)
27.01
(1733)
0.017
ND
[4]
families
694
338/356
31.65-52.03
Predominantly
Caucasian ,
Boston area
26.1928.31
26.8729.97
(102)
24.58-27.69
(305)
24.6-27.04
(275)
<0.05
ND
[4]
families
467
Male
38.72
(10.88)
African
American
31.83
(8.71)
31.06
(31)
33.07
(151)
32.87
(285)
<0.05
ND
[4]
families
363
Female
38.02
(11.09)
African
American
27.76
(7.20)
27.47
(9)
27.37
(132)
28.40
(222)
<0.05
ND
[4]
41.99
(12.03)
43.97
(10.06)
African
American
African
American
Germany,
Caucasian
Germany,
Caucasian
European,
Caucasian
European,
Caucasian
41.87
(6.54)
21.28
(1.79)
38.90
(15)
20.71
(6)
42.95
(73)
20.89
(60)
43.44
(91)
21.07
(111)
<0.05
ND
[4]
<0.05
ND
[4]
>27
27.38
27.16
27.18
0.65
ND
[16]
>27
30.35
29.72
29.53
0.007
ND
[16]
26
(3.7)
27.2
(4.8)
25.9
(493)
27.0
(180)
25.8
(2157)
27.3
(710)
26.1
(2261)
27.3
(793)
0.06
ND
[14]
0.61
ND
[14]
KORA S4
FHS (exam 1 to
exam 5)
MAYWOOD
MAYWOOD
WHO
MONICA
(cardiovascular
disease
project)
Not selected
for a particular
trait
Regardless of
obesity
phenotype
Regardless of
obesity
phenotype
MAYWOOD
Obese- cases
unrelated
179
ND
MAYWOOD
Lean- control
group
unrelated
177
ND
SHIP
(61% Obese)
unrelated
4304
ND
20-79
SHIP-subgroup
Overweight
unrelated
2701
ND
ND
Epic5000
Cancer
unrelated
4911
2172/2739
ND
MRC ELY
22% obese
unrelated
1683
772/911
ND
Additional Table 2-contined. Summary Table of Results for the INSIG2 variant in the literature up to
March 01 2008
Cohort
DESIR
DESIR
Disease
Sample or
exam
N
(genotyped)
Insulin resistance nonrandom
selection
Insulin resistance nonrandom
selection
unrelated
4998
ND
Obesity
ND
Obesity
ND
Obesity
MALE/
FEMALE
Female
Male
386
families(1765
subjects)
+350 obese,
230 nonobese
unrelated
449 families
(2426
subjects) +
145 severe
obese
unrelated
Female
AGE
Mean
(SD)
middleaged
middleaged
adult
966
ETHNICITY
French,
Caucasian
French,
Caucasian
French,
Caucasian
BMI
Mean
(SD)
Mean
BMI
C/C(N)
Mean
BMI
G/C(N)
Mean
BMI
G/G(N)
Given
p
value
ND
23.87
24
24.09
>0.05
ND
[9]
ND
25.35
25.54
25.43
>0.05
ND
[9]
ND
38.05
37.38
39.31
>0.05
ND
French,
Caucasian
ND
34.26
35.44
34.46
>0.05
ND
[9]
Female
child
French,
Caucasian
ND
2.45
2.6
2.49
>0.05
ND
[9]
Male only
child
French,
Caucasian
ND
2.67
2.21
2.4
>0.05
ND
[9]
25.62
(113)
26.2
(284)
29.3
(85)
35.7
(106)
26.7
(95)
26.6
(205)
25.94
(570)
26.3
(1135)
29.4
(329)
36.5
(455)
27.6
(360)
26.4
(770)
26.13
(689)
26.2
(1302)
26.7
(333)
35.9
(465)
26.8
(363)
26.6
(721)
>0.05
ND
[10]
0.39
ND
[17]
0.97
ND
[17]
>0.05
ND
[8]
>0.05
ND
[8]
>0.05
ND
[8]
233
962
1038
0.3
ND
[31]
21
125
147
0.007
ND
[15]
3542
HTO
Hypertension
248 families
1425
ND
18.7-90.7
UK, Caucasian
25.4
NPHSII
Control group
unrelated
2721
Male
56.1
UK,Caucasian
ND
UDACS
T2D and CAD under therapy
unrelated
742
ND
ND
UK, AfroCaribbean-Indian
ND
unrelated
1040
[9]
adult
Obesity
Obesity
Ref.
Male
ND
UTAH
Obesity
Assoc.
Test* p
191/835
UTAH
Control group
unrelated
840
396/422
SAPHIR
Atherosclerosis prevention in
sample has high risk
unrelated
1770
1107/626
Japanese cohort
Randomly selected
unrelated
2233
1128/1105
44.4
(11.4)
52.8
(8.5)
51.8
(8.5)
Utah, Caucasian
Austria,
Caucasian
46
(7.6)
27.6
(4.9)
26.8
(4.1)
40-79
Japan
22.8
Utah, Caucasian
German cohort
Obese-Cases-1yr intervention
unrelated
293
132/161
10.8
Caucasian
28.1
(*) Obesity association test: BMI>30 kg/m2 vs. BMI<30 of the C/C genotype at rs7566605 were compared and p values reported, please see ref 30 for details.