Study Schedule of Events
INFANT AGE
FIELDWORK PROCEDURE
BIOLOGICAL SAMPLES
10-28 wks gestation
Recruitment & enrolment period
NIL
28-32 wks gestation

Interview/questionnaire, EDS & PSS
36 weeks

Birth
Prior to discharge following delivery
(0-5 days of life)
Prior to discharge following delivery (0-5 days of
life)
Eligible babies born >37 weeks gestation with
birth weight of <2.5kg
2 weeks
OPTIONAL EXTRAS
Fetal Growth Scan (Barwon Health
participants only)
NIL

Interview/questionnaire

Clinical examination including;

Infant growth measurements
Up to 5 days of life, after which classify as “missed”
10/24_S4 IUGR sub study ONLY:

Recruitment & enrollment

Clinical examination including; Infant
growth measurements
Up to 5 days of life, after which classify as “missed”
Telephone conversation with BIS Paediatrician
regarding Monthly Infant Health Diaries
4 weeks

1st clinic visit to CHRU (full term infants)
Interview/questionnaire, EDS & PSS

Clinical examination including*;

Infant growth measurements

Anthropometric measurement of biological
parents
(weight,
height
&
head
circumference)

Eczema assessment

Maternal blood
(optimum period for collection between 26-30wks) Max range
up to 32 weeks, after which classify as “missed”

Maternal faeces

Maternal urine
As close to 36th week- ask mothers to freeze faeces as close
to this date- if do not have time to drop off earlier. Acceptable
anytime from 35th week until delivery

Cord blood

Cord tissue sample

Placenta sample

Meconium

Infant nasal swab
NIL
NIL

Maternal hair

Infant hair

Infant faeces
As close to 4 weeks of age- ask mothers to freeze faeces as
close to this date- if do not have time to drop off earlier

Infant urine

Breast milk

Infant nasal swab
OPTIONAL EXTRAS
Lung function testing using MBW machine
(optional)
As close to 4 weeks of age- acceptable up to 12
weeks of age but must be 3 weeks after having a
URTI/LRTI or respiratory illness

4 weeks (IUGR sub study participants)
3 months

Abdominal Ultrasound (optional)
As close to 4 weeks of age- acceptable up to 6
weeks of age.
10/24_S4 IUGR sub study ONLY:

Interview/ Questionnaire

Clinical examination including; Infant growth
measurements

Abdominal Ultrasound (optional) As close to
4 weeks of age- acceptable up to 6 weeks
of age.
Telephone interview/ questionnaire (full term infants)
NIL
NIL (full term infants)
*1st clinic visit to CHRU will be offered to families of
preterm infants (Only infants born between 31wks7days and 36wks- 6 days gestation) at approx. 3
months of age.
6 months

2nd clinic visit to CHRU (all infants)
Interview/questionnaire & PSS

Clinical examination including*;

Infant growth measurements

Eczema assessment

Infant faeces (Only Infants born between 31wks7days and 36wks- 6 days gestation)
 Infant blood
 Infant faeces
As close to 6 months of age- ask mothers to freeze faeces as
close to this date- if do not have time to drop off earlier

Breast milk

Infant nasal swab

Infant saliva swab

Mother/primary care giver saliva swab
9 months
Telephone interview/ questionnaire
‘Home Visit’ (10/24 S3) including:



12 months
Home Environment Questionnaire
Developmental Assessment
Environmental sample collection
‘Home Visit’ (10/24 S3) samples
include:
3rd clinic visit to CHRU (all infants)
Interview/questionnaire & PSS

Clinical examination including*;

Infant growth measurements

Eczema assessment

Skin Prick Testing
(Medications with antihistamine-like actions (Some
teething mixtures, some cold remedies and
antihistamines, eg: Claratyne, Zyrtec, Phenergan,
Telfast etc) should not be taken for 7 days before
testing as these will interfere with the results of
testing).




Urine
Dust
Hair



Infant blood
Infant urine
Infant faeces
As close to 12 months of age- ask mothers to
freeze faeces as close to this date- if do not
have time to drop off earlier
Breast milk
Infant nasal swab
Infant saliva sample




Abdominal Ultrasound
(Only for infants who have had the 4 week abdominal
ultrasound)

Oral food challenges (10/24_S2)
(Only for infants demonstrating allergic sensitisation to
peanut, cashew, egg, cow’s milk or sesame on SPT.
Oral Food Challenge to be held within 2 weeks
following a positive skin prick test).
18months
2 Years
Telephone interview/ questionnaire (verbal consent)
Interview/questionnaires;
o
2yr RA Admin Questionnaire
o
2yr Self-Admin Questionnaire
o
Home Environment: Past & Present
Questionnaire
o
EDS & PSS
o
The Child Behavior Checklist (CBCL)
Clinical examination including;
Height & weight measurement
Developmental Assessment

Bayley Scales of Infant Development

Parent Report of Children's Abilities (PARCA)

and MCDI:UKSF

Free-Play
NIL



Child faeces
Child urine
Child hair
Preschool age
(45 to 50 months of age)
Interview/questionnaires;
o
Preschool Questionnaire
o
Preschool Food Frequency Questionnaire
o
Preschool Perceived Stress Scale /Edinburgh
Depression Scale
o
Preschool Physical Activity Data Collection
Form
Cardiovascular components of the review:
o
Abdominal & Carotid Ultrasound
o
Measure blood pressure
o
Pulse Wave Velocity
Respiratory components of the review:
o
Lung function testing using MBW machine
o
Forced Oscillation Test
Neurodevelopment components of the review:
o
o
Executive Function tests (tablet computer based
games)
NIH Picture Vocabulary Test
Clinical examination & other activities;
o
Eczema assessment (SCORAD)
o
Skin Prick Test
o
Physical activity measured via use of
accelerometer worn by child during waking
hours (7-day period)
o
Infant anthropometrics:
a.
Height (standing & sitting)
b.
Weight
c.
Waist, thigh, head & upper arm
circumference
d.
Skinfolds (triceps & subscapular)
o
Parental anthropometrics:
e.
current weight (mother/father)






Child urine
Child faeces
Child nasal swab
Child buccal swab
Child blood (optional extra)