Programme, 28th October, Sunday
14:00-14:15
B5 Auditorium, Franklin-Wilkins Building
Waterloo Campus
Opening presentation by Prof. Silvio Aime (University of Torino, Torino, Italy)
WG1 Imaging reporters for theranostic agents
14:15-14:20
Short introduction by WG1 leader Eva Jakab-Toth (CNRS, Orleans, France)
14:20-14:35
Imre Tóth (University of Debrecen, Hungary)
"Mixed ligand metal-complexes modelling anion binding: the hard aluminium(III) and the
soft thallium(III)"
14:35-14:50
Hanno Schieferstein (Johannes Gutenberg-University, Mainz, Germany)
"Folate receptor targeted delivery of supramolecular drug-carriers monitored by PET"
14:50-15:05
Tobias Ross (Johannes Gutenberg-University, Mainz, Germany)
"Radiolabelling of TaOx nanoparticles for dual-modality imaging"
15:05-15:20
Jonathan Martinelli (University of Piemonte Orientale A. Avogadro, Italy)
"Host-guest paramagnetic supramolecular assemblies"
15:20-15:35
Stephane Petoud (CNRS, Orleans, France)
"Polymetallic lanthanide metal-organic frameworks for biological imaging in cells"
15.35-15.55
Coffee break
15:55-16:10
Alexandra Foucault (CNRS, Orleans, France)
"Near-infrared luminescent polyaminoamide lanthanide dendrimer for tumor diagnostic"
16:10-16:25
Rabha Kerdjoudj (Subatech,Nantes, France)
"Evaluation of 44Sc radiopharmaceuticals derived from DOTA-based phosphonic acids "
16:25-16:40
Edyta Leszczuk (Institute of Nuclear Chemistry and Technology, Warsaw, Poland)
"TiO2 nanoparticles as vehicles of
16:40-16:55
212Pb
and 225Ac for internal radiotherapy"
Seweryn Krajewski (Institute of Nuclear Chemistry and Technology, Warsaw, Poland)
"44,43Sc and 47Sc as matched pair for theranostic approach to peptide receptor
radionuclide therapy"
16:55-17:10
Sandip M. Vibhute (Max Planck Institute for Biological Cybernetics, Tübingen, Germany)
"Synthetic modification of pH sensitive contrast agents for attachment to functional
molecules and its utilization in biotin-avidin system"
17:10-17:25
Dorothea Moderegger (Johannes Gutenberg-University, Mainz, Germany)
"Molecular imaging of HPMA-based drug carrier systems: Influence of size and polymer
architecture on body distribution and tumor uptake in vivo"
17:30-19:30
MC meeting (for MC members and the MC substitutes)
Programme, 29th October, Monday
Henriette Raphael Function Room
Guy’s Campus
WG2 Characterization of Nanocarriers for theranostic agents
09:00-09:05
Short introduction by WG leader Ruth B. Schmid (SINTEF, Norway)
Physico-chemical methods:
09:05-09:20
Neus Lozano (University College London, London, UK)
"Liposome-gold nanorod hybrids for high-resolution visualization deep in tissues"
09:20-09:35
Elias Fattal (University Paris-Sud, France)
"Physico-chemical characterization of nanoparticles in regards to fate and toxicity"
09:35-09:50
Ulrich Schatzschneider (Julius-Maximilians-Universität, Würzburg, Germany)
"Strategies for the modular conjugation of bioactive functional groups to solid nanocarrier
materials"
09:50-10:05
Aurélie Jacquart (CEA-Leti, Grenoble, France)
"Nanocharacterisation of Lipidots"
10:05-10:20
Magdalena Stevanović (Serbian Academy of Sciences and Arts, Belgrade, Serbia)
"Polyester micro- and nanospheres as carriers for different medicaments"
10:20-10.35
Vesa-Pekka Lehto (University of Eastern Finland, Kuopio, Finland)
"Characterization aspects of nanoporous inorganic materials"
10:35-10:50
Stefaan de Smedt (Ghent University, Belgium)
"Advanced fluorescence microscopy to study nanomedicines"
10:50-11:20
Coffee break & poster session
11:20-11:35
Maria Antonia Herrero Chamorro (University of Castilla-La Mancha, Spain)
"Chemical functionalization and characterization of carbon-based nanomaterials"
In vitro and in vivo models:
11:35-11:50
Maria José Alonso (University of Santiago de Compostela, Spain)
"Polymer nanostructures for overcoming biological barriers"
11:50-12:05
Francesca Baldelli Bombelli (University of East Anglia, Norwich, UK)
"Engineered nanoparticles: the bionano interface in a biological environment"
12:05-12:20
Maria Blanco Prieto (University of Navarra, Spain)
"Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid
nanoparticles"
12:20-12:35
Karine Andrieux (University Paris-Sud, France)
"In vitro BBB models for studying nanoparticles translocation"
12:35-12:50
Huw Summers (Swansea University, Swansea, UK)
"Development of assays and models for a pharmacology of nanoparticle drug delivery
vectors"
12:50-13:05
Khuloud T. Al-Jamal (Kings College London, London, UK)
"Magnetic carbon nanotubes for dual in vivo imaging"
13:05- 14:05
Lunch break & poster session
WG4 Theranostic agents responsive to endogenous and external stimuli
14:05-14:10
Short introduction by WG4 leader Gerben Koning (Erasmus Medical Center, Rotterdam,
Netherlands)
14:10-14:40
David Needham (University of Southern Denmark, Odense, Denmark; Duke University,
Durham, USA)
"Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to
improve drug penetration into tumors"
14:40-15:00
Adam Gormley (Imperial College London, London, UK)
"Light and heat guided drug delivery"
15:00-15:20
Ann Seynhaeve (Erasmus Medical Center, Rotterdam, Netherlands)
"Tumor vessel manipulation to improve drug delivery"
15:20-15:40
Chantal Pichon (Université d'Orléans, France)
"Ultrasound and microbubbles assisted- gene delivery: in vitro mechanistic investigations
and in vivo efficacy"
15:40-16:10
Coffee break & poster session
16:10-16:30
Laila Kudsiova (King’s College London, London, UK)
"Delivery of anionic vs. cationic lipopolyplexes to the brain via CED"
16:30-16:50
Olivier Tillement (Université de Lyon, France)
"Radiosensitizing effect of ultrasmall gadolinium based particles"
16:50-17:10
Wafa Al-Jamal (UCL School of Pharmacy, UK)
"Different hyperthermia protocols and their effect on drug release"
17:10-17:30
Zahraa Al-Ahmady (UCL School of Pharmacy, UK)
"Lipid–peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia
in vitro and in vivo"
17:30-18:30
Cheese and wine reception & poster session
Programme, 30th October, Tuesday
Henriette Raphael Function Room
Guy’s Campus
WG4 Theranostic agents responsive to endogenous and external stimuli
09:00-09:20
Goran Angelovski (Max Planck Institute for Biological Cybernetics, Tübingen, Germany)
"Dynamic and target-specific MRI probes for neuroimaging"
09:20-09:40
Catharina de Lange Davies (NTNU, Trondheim, Norway)
"Ultrasound enhanced uptake and improved microdistribution of multifunctional
nanoparticles in prostate tumours in mice"
09:40-09:55
Stanley Fokong (University of Aachen, Germany)
"Image-guided, targeted and triggered drug delivery to tumors using polymer-based
microbubbles"
09:55-10:10
Silvia Rizzitelli (University of Torino, Italy)
"In vivo MRI visualization of the intratumor release of doxorubicin from liposomes by non
focused ultrasound"
10:10-10:40
Coffee break & poster session
WG3 Preparation and selection of targeting vectors
10:40-10:45
Short introduction by WG3 leader Robert Muller (University of Mons, Belgium)
10:45-11:05
Sarah Belaïd (University of Mons, Belgium)
"Physicochemical properties of ultrasmall iron oxide nanoparticles synthesized by thermal
decomposition"
11:05-11:25
François Lux (Université de Lyon, France)
"AGuIX: a new class of theranostic particles"
11:25-11:45
Maria Laura Bolognesi (Università di Bologna, Italy)
"A fluorescent small molecule with combined therapeutic and diagnostic activities against
Alzheimer’s and prion diseases"
11:45-12:05
Sijumon Kunjachan (RWTH Aachen University Clinic, Germany)
"Hybrid CT-FMT imaging of tumor vascular targeting"
12:05-12:25
Maria Garrido (University of Navarra, Spain)
"Targeting of epidermal growth factor receptor in colon cancer cell lines with PEGylated
liposomes coupling to different ligands"
12:25-12:45
Twan Lammers (Universiteit Utrecht, Netherlands)
"Passive versus active targeting"
12:45-14:05
Lunch break and poster session
WG5 Set-up of preclinical theranostic protocols
14:05-14:10
Short introduction by WG5 leader George Loudos (Technological Educational Institute
of Athens, Greece)
14:10-14:30
Tim Devling (iTheraMedical, Neuherberg, Germany)
"Multispectral Optoacoustic Tomography (MSOT) in drug delivery"
14:30-14:50
George Loudos (Technological Educational Institute of Athens, Greece)
"Initial experience from the assessment of magnetic hyperthermia effect using in vivo
nuclear imaging"
14:50-15:20
Coffee break & poster session
15:20-15:40
Eirini Fragogeorgi (Technological Educational Institute of Athens, Greece)
"Preliminary in vitro and in vivo evaluation of a 99mTc labelled hybrid magnetic
nanocarrier"
15:40-16:00
Rafael Torres M. de Rosales (King's College London, London, UK)
"Exploring potential applications of bimodal PET-MR nanoprobes in imaging and therapy"
16:00
Closing remarks by Prof. Silvio Aime (University of Torino, Torino, Italy)
Poster Presentation
1. Florian Mayer, P. van der Est, R. Goverde and K. Djanashvili (Delft University of Technology,
Netherlands), "Fluorogenic click reactions for nanoparticles functionalization".
2. W. Zhang, F. Mayer, J.A. Peters and Kristina Djanashvili (Delft University of Technology,
Netherlands), "Ln(III)-loaded zeolites for multimodal imaging".
3. Ana C. Mendonça, André F. Martins, Andreia Melchiorre, Sérgio M. Marques, Sílvia Chaves,
Stéphane Petoud, P.L. Zanonato, Marilena Tolazzi, Célia S. Bonnet, Éva Tóth, Plinio di Bernardo,
Carlos F.G.C. Geraldes and M. Amélia Santos (University of Coimbra, Portugal), "New lanthanide
complexes with a Tris-3,4-HOPO ligand, as new potential imaging probes".
4. Lorenzo Tei (University of Piemonte Orientale A. Avogadro, Italy), "Small sized liposomes and
discoidal micelles by incorporation of amphiphilic Mn(II) complexes".
5. Mauro Botta (University of Piemonte A. Avogadro, Italy), "A novel ditopic Gd(III) complex
functionalized with an adamantyl moiety".
6. Célia Bonnet (CNRS, Orleans, France), "Zinc responsive agents".
7. Michal Maurin (NCNR Radioisotope Centre POLATOM, Poland), "Preliminary results of
radiolabelling of ultra small rigid particles as multimodal probes".
90Y
8. Agata Piotrowska, E.Leszczuk and A.Bilewicz (Institute of Nuclear Chemistry and Technology,
Warsaw, Poland), "Nanozeolite as a vehicle for 223,224,225Ra radionuclides".
9. C. Tsoukalas, T. Tsotakos, M. Meckel, V. Kubicek, S. Xanthopoulos, P. Hermann, F. Roesch and P.
Bouziotis (Demokritos, Athens, Greece), "Attempts toward the development of dual-modality imaging
agents based on the conjugation of biphosphonates directly to the surface of superparamagnetic iron
oxide nanoparticles".
10. Zsolt Baranyai, Anett Takács, Balázs Podolyák, Mihály Purgel, Roberta Napolitano, Silvio Aime, Ernő
Brücher and Imre Tóth (University of Debrecen, Hungary), "Equilibrium, kinetic, relaxation and
structural properties of H3DO3A-sulfonamide ligand and its Ca2+, Zn2+, Cu2+ and Ln3+-complexes".
11. Ondrej Zemek, Jan Kotek and Petr Hermann (Charles University, Czech Republic), "Monophosphinic
acid DOTA analog for "click" chemistry".
12. Eva Jakab-Toth (CNRS, Orleans, France), "Liposomes and Lipoproteins as bimodal imaging probes".
13. Silvia Fontenete, N. Guimarães, M. Leite, C. Figueiredo, J. Wengel and N.F. Azevedo (University of
Porto, Portugal), "Nucleic acid mimics hybridization at human body temperature in Heliobacter pylori".
14. Rita S. Santos, Nuno Guimarães, Pedro Madureira and Nuno F. Azevedo (University of Porto,
Portugal), "Impact of the external cellular milieu on the diffusion and hybridization of nucleic acids in
bacterial cells".
15. Jussi Rytkönen (University of Eastern Finland, Finland), "Intracellular delivery of antisense
oligonucleotides with porous silicon nanoparticles".
16. Desire Di Silvio (University of East Anglia, UK), "Study of the interaction between protein corona
nanoparticles and lipid bilayers as cell membrane models".
17. Aarthi Rekha Devarajan (University of East Anglia, UK), "Hazard assessment of engineered
nanocarriers using in vitro and in vivo toxicity studies".
18. Francisco Silva, A. Zambre, Anónio Paulo, R. Kannan and Isabel Santos (Universidade Técnica de
Lisboa, Portugal), "Multifunctional gold nanoparticles for theranostic applications".
19. D. Stanicki, S. Laurent, L. Vander Elst, R.N. Muller (Umons, Belgium), "Flurophore-tagged iron oxide
nanoparticles as bimodal contrast agents for MRI and optical imaging".
20. E. Lipani, S. Laurent, M. Surin, L. Vander Elst, P. Leclère, R. Lazzaroni, Robert Muller (Umons,
Belgium), "Characterization of biomedical nanomaterials for Magnetic Resonance Imaging".
21. Tamara Čačev and Kapitanovic, S (Rudjer Boskovic Institute, Croatia), "Cancer as a challenge of the
theranostic nanomedicine and Laboratory for Personalized Medicine (IRB)".
22. Lydia Sandiford and Rafael T. M. de Rosales (King’s College London, UK),
"Bisphosphonate-anchored PEGylation and radiolabeling of superparamagnetic iron oxide:
Ultra-stable nanoparticles for in vivo multimodal imaging".
23. Javier Guerra, A.M. Herreros, C. Martín-Jiménez, M.D. Pérez-Carrión, F.C. Pérez-Martínez, J.C.
García-Martínez, S. Merino. J. Tejeda, P. Sánchez-Verdú, V. Ceña, J. Rodríguez-López (University of
Castilla-La Mancha, Spain), "Gold nanoparticles in assembled gene delivery carrier".
24. Raha Ahmad Khanbeigi, Zeina Hashim, Mark Green, Helen Collins and Lea Ann Dailey (King’s
College London, UK), "Synthesis and safety assessment of conjugated polymer nanoparticles
as photostable imaging agents".
25. Wouter JM. Lokerse, Sarah Belaid, Sophie Laurent, Timo LM. ten Hagen, Alexander MM. Eggermont,
Holger Gruell, Robert N. Muller and Gerben A. Koning (Erasmus Medical Centre, Rotterdam,
Netherlands) "Magnetic nanoparticles for localized hyperthermia and controlled drug release in solid
tumors".
26. Michiel Bolkestein, Dubravka Drabek, Timo L.M. ten Hagen, Alexander M.M. Eggermont, Frank G.
Grosveld and Gerben A. Koning (Erasmus Medical Centre, Rotterdam, Netherlands)
"Immunoliposomes with single-domain antibodies targeted agains epidermal growth factor receptor
(EGFR)".
27. Michael Wright, Elena Rosca, Roman Gonitel, Andrew D. Miller, Wladyslaw Gedroyc and Maya
Thanou (King’s College London, UK) "Image-guided focused ultrasound for targeted anticancer drug
delivery".
28. Patrick Wilhelm, Carsten Kroll, Helmut R. Maecke and Helma Wennemers (Laboratory of Organic
Chemistry, ETH Zürich, Switzerland) "Oligoproline as a molecular scaffold for tumor targeting"