Curriculum Vitae Yuri Magarshak, Ph.D. President, MathTech.Inc., President of the International Committee for Intellectual Collaboration, President MathTech, Inc. 2925 W 5ths Str. Suite 3E Brooklyn NY 11224 (718)946-5015, ym4@nyu.edu EXPERTISE: -Analytical and computer modeling and statistics in molecular biology, pharmacology, physiology and medicine. -RNA folding and dynamics. - Neural nets Color vision and stereo vision, new principles of computing. -Diagrammatic analysis of structured systems with large number of components. -Enzyme regulation and kinetics. -Creation and managing multi-disciplinary teams. Frontiers high-tech projects in application to internet and control systems. EDUCATION: 1968: M.S. In Theoretical and Mathematical Physics, Leningrad State University, School of Physics, Department of Mathematical and Theoretical Physics. Graduated with honors. 1972: Ph.D. In Theoretical and Mathematical Physics, Leningrad State University, School of Physics, Department of Mathematical and Theoretical Physics PROFESSIONAL EXPERIENCE: 1997-Present: President, MathTech, Inc. (New York, USA) 2009-Present: President, International Committee for Intellectual Collaboration 2001-2009 Executive Vice President, International Committee for Intellectual Collaboration 2007-Present Distinguished Professor, University of Dubna (Russian Federation) 1994-Present: Visiting Professor, Courant Institute of Mathematical Sciences, NYU 1997-1998: CEO, InfoPlanet Technologies, Inc. 1994-1996: Vice President, Research and Development, PhyTech, Inc. 1991-1993: Visiting Associate Professor, Department of Biomathematical Sciences. Mount Sinai School of Medicine of City University of New York 1989-1990: Senior Research Associate, Department of Chemistry, New York University. 1978-1988: LTU (Leningrad, USSR), Member of Research Stuff. 1972-1978 Chair of the Lab of Biomathematical Simulations, Associate professor, assistant professor. North-West Polytechnic Institute, Leningrad (USSR). 1 OTHER PROFESSIONAL ACTIVITIES: Organizing committee, Advisory Committee and Program Committee Member for several major conferences. Foreign Member of Russian Academy of Natural Sciences Chair of the organizing committee of NATO workshop Silicon vs. Carbon (2008) Co-chair of the workshop Commercialiation of Nanotechnologies, Sanct Petersburg 2008 КОММЕРЦИАЛИЗАЦИЯ НАНОТЕХНОЛОГИЙ Co-chair of the symposium Gray holes of history Co-chair of the international workshop Physics of atoms: new ideas and prospects (2008 Co chair of the symposium Civilization of 21st century: technological and humanitarian aspects Moscow 2006) Co-chair of the workshop Fragmentation and Globalization in Human Civilization Chair of the organizing committee of International Advanced Research Workshop NATO Environmental and Biological Risks of Nanobiotechnology, Nanobionics and Hybrid Organic-Silicon Nanodevices (Silicon vs. Carbon) Reviewer of a number of journals. Intellectual Forum (USA-Russia), board member President of the Intellectual Renaissance Society (New York) Editorial Board Member of the International Journal of Alternative Energy and Ecology Editorial Board Member of the Ecology and Life Journal Editor, New and Old Ideas in Physics European Journal Vice-Chair of Biophysical Council, Sanct Petersburg (USSR) Board Member, Physics Council Member: Educational Alliance, Sanct Petersburg Branch. PUBLICATIONS: Over 100 scientific papers in referenced journal. Over 200 publications in non-references Journals and Magazines. CITIZENSHIP: US Citizen References furnished upon request 2 Summary of Selected Scientific and Technical Contributions. Invention and creation of new engine for database representation and Internet navigation (InfoPlanet). This is ongoing project. The new principle of representing database by surfaces has been developed. The personal US patent has been received. In exchange for investment and cash, the work on the prototype is been performing by InfoPlanet Technologies, Inc., and supervised by Yuri Magarshak as C.E.O. Analysis of RNA Folding and Dynamics. Loop and gap migration models of RNA dynamics have been suggested and analysed. . With newly developed formalism of projective matrix analysis, equations of RNA loop migration have been derived. Computer analysis of structure of a number of genome sequences has been performed. It was demonstrated that the distribution of sequence symmetries in HIV genome is region-dependent. Experiments with an RNA spliced leader, which reveal the switch between two alternative structure forms, have been analyzed. The model of knot dynamics, which follows from this approach, has been suggested and tested. Knot Invariants of RNA secondary structures have been found and analyzed (in collaboration with L.Kauffman). The statistical-mechanical approach to secondary structure formation during RNA chain elongation has been tested on Ala-tRNA sequence. Computations demonstrate bifurcation of secondary structure pathways as intermediate state, and convergence to the unique final secondary structure, known from experiment. Electron Transfer in Macromolecules. This work was started in 1989 at NYU and continued at Mount Sinai School of Medicine of City University of New York. First, diagrammatic solution of Dyson system for electron tunneling has been suggested. The method reminds Anderson technique for solid state physics, but is applicable to large structured systems without translation symmetry. Second, the diagrammatic solutions for Green functions has been derived for alpha-helical peptides, for graphs with one backbone and side groups touching it at a single site, for tree-like pathways scheme (like hydrocarbons) and other biologically important models. The computation of electron transfer rate, based on this theory along with 3D-energy minimization, has been performed for a number of organic molecules. Further, the formula of Green function for the systems which can be subdivided into weakly coupled clusters, has been derived. The method of topological renormalization has been generalized on the schemes with arbitrary number of cycles, if cyclic sub-schemes (for instance, side-groups) form a tree. Vertices of transformed diagram correspond to Hamiltonians of sub-schemes. The possible resonance phenomena caused by bifurcation of in electron paths, has been predicted. As a result of resonance, at bifurcation point of electronic paths, electron can tunnel through one barrier rather than through another. To brake the symmetry in such a way, a small perturbation of hopping integral is sufficient. Such a resonance can explain the effect of electron transfer along only one of two paths, in particular, in photo reaction center. 3 Pattern Recognition and signal analysis. In 70-ies in the lab of Biomathematical Simulations the investigation of pattern recognition in application to radio location has been performed under my supervision. This work was supported by grants of Navy of the USSR, so results and reports in this field were classified. In general, I have directed the work on Spectral Analysis of Pseudo-Random Signals in Aqua Media. Evaluation Error of Statistic Characteristics of Pseudo-Random Signals With Discrete Sampling were thoroughly investigated. The computations were performed with signals from submarines in Baltic Sea. A number of criteria have been tested. As a result, new algorithm for early detection of submarines has been developed. Diagrammatic Solutions of Equation Systems. In many applications, one has a set of hundreds, thousands or millions of equations, in which most of the elements are equal to zero, and the disposition of non-zero elements is regular. This situation is pretty typical for molecular biology, economy, computer sciences, electronics and other fields. In such system, main properties of solution depend on the structure of the system rather then on values of coefficients. For instance, the Green-function of tree-like Dyson system is also tree-like branched continued fraction, and the structure of this continued fraction has one-to-one correspondence with the structure of Dyson system itself (Magarshak, Malinsky, 1991). One also can derive continued fraction solution for electric resistance of regular hexagonal net (we derived it first in application to analysis of lipid bilayers). The project was started in collaboration with M.Volkenstein 20 years ago. Since than we have solved diagrammatically a number of equation systems of diverse structured forms. This approach has been applied on electron tunneling, enzyme kinetics, RNA dynamics, lipid bilayer and neural nets. The general theory of solution of structured systems is not developed yet, so the project is on-going. Electrical Properties and Topological Transformations in Membranes. This work was performed in University of Texas (Galveston), in order to explain experiments of H.Fishman with Earthworm Medial Giant Nerve Fiber and Squid Giant Axon. The model of the resistance of regular hexagonal nets with different dislocations and diverse shapes of holes in it has been developed. The continued-fraction solutions for finite number of elements, which was derived, tend to the experimentally measured values. Experiments with cut giant axon reveal a lot of spherical vesicles of various diameters which a. move to the hole, b. Change the shape so that the contact surface between them is maximized, c. close the gap forming the plug, d. fuse, so that in some cases one huge bubble is formed, and e. at least in some cases, seal the axon. The problem of vesicle fusions has been analyzed as 3D-percolation problem. The problem of vesicles shape in the plug region has been treated as the set of minimal energy surfaces. The possible structures of dislocation regions in the hexagonal net (bilayer) is under study. In these and other experiments it has been demonstrated that interaction of membrane hole with a vesicle requires the formation of bifurcation of bilayer. The work is continued. 4 Entropy Production by Enzymes in Non Equilibrium Range, and Analysis of Stationary and Non Stationary Multi Enzyme Systems. In 1985-1988, in collaboration with Prof. Stephanov (Leningrad State University), the theory of enzymeуs entropy production has been developed. As a result of computer simulations, the entropy production for main mechanisms of enzyme reaction was computed. In particular, calculations show that kinetics of at least some allosteric enzymes can be unstable in the sense of Lyapunov. In 1989 at Courant (NYU) the non-linear behavior of a number of multi enzyme systems in the far-from-equilibrium zone have been simulated and plotted. The plots demonstrate diverse time-dependent behavior and limit-cycles. The approach was also applied to creatine kinase reaction complex. Projective Geometry in Application to Color Vision and Neural Nets. The principles of neural net functioning on cognition level are still unknown. It is commonly accepted that in the brain some kind of algebraic structures are formed. On the other hand, all chemical signals are non-negative, and actually the set of such signals forms the cone rather than ring or algebra. One can get algebra of complex numbers by projectivegeometrical transformations on cones with dimensions 3 and 4 and non-negative components, and algebra of quaternions, as well as that of dual numbers, by projectivegeometrical transformation on cones with dimension 8 (the last formalism one can consider as generalized spinors). In this approach, oscillation of the image on retina generates kind of Feynman integral along trajectories. The projective geometrical model of neural nets functioning is suggested (in collaboration with professor F.Bogomolov). The application of this approach to color vision sounds natural and straightforward. These results might be equally useful in application to computer science, imaging and pattern recognition. Analysis of spectral properties or biological micromolecules. In order to diminish drastically the probe dose and improve treatment of mentally ill and other patients, spectral properties of proteins of spinal fluid of mentally have been analyzed. Now standard, at that time this method was new. The work was performed under my supervision and supported by the grant of Ministry of Health of Russian Federation. 5 Diagrammatic Methods in Application to Enzymatic Activity. The work was started as graduate research (advisor Michael V.Volkenstein). At first, it has been proven that cycled and uncycled graphs give identical solutions for balance equations (sum of matrix element of each column is zero), if the product of rate constant in clockwise and counter clockwise directions are equal for each cycle. This, now well know, result allowed drastically improve method of King and Altman by uncycling kinetic schemes and getting partition function rather then series of rate constants. A number of kinetic mechanisms of enzyme reaction (ping pong, allosteric enzymes etc.) have been analyzed. Diagrammatic method of kinetic predictions based just on the reaction scheme has been suggested. For a number of biologically important enzyme systems, one-to-one correspondence between the kinetic diagram, which elements are considered symbolically as mathematical operations, and rate dependence on metabolites concentrations, has been demonstrated. It has also proven, that in the presence of symmetry group, equations can be simplified and solutions degenerate. the symmetry brake removes degeneration and splits solutions. For systems in which clusters are connected by rate-limited steps, the diagrammatic solution has been given. On the bases of this theory, computer simulation of kinetic behavior of a number of allosteric enzymes has been performed. Short term projects. Three dimensional periodic table of elements (Publication in ‘Nature’, 1992). Group-theoretical approach to the structural analysis of poetry (1989). Application of the graph-theoretical approach on the analysis of the plot of ‘Hamlet’ Shakespeare (1991). Creation of the interactive computer programs ‘Intel 100’ and ‘Intel 200’ for improving reading, memorizing and comprehension abilities (1987-1989). Creation of the computer programs for ultraviolet and infrared color vision with global and local adjustment of colors and applications of this approach on medicine. The design of computer programs in order to investigate experimentally non-linear effects of human vision (in collaboration with professor O.Franzen, University of Uppsala, Sweden) has been performed. At present, some of newly discovered effects are under study. 6 Yuri Magarshak LIST OF SELECTED PUBLICATIONS. Yu. Magarshak Gluconics as the Universal Renewable Energetic the SITA Journal Vol. 12 . 189-194 (2010) E. Levich, A. Libin, Y. Magarshak “Helical theory of turbulence in fluids and plasma and possible Implications for coherent organization in Cosmos” J. Scientific Israel – Technological Advantages (SITA), Vol.12 1-2. pp. 186-191 (2010) O.Figovsky, Y.Magarshak “Altervital Energy – Nanotechnology in Vivo” (2010) International Scientific Journal of Alternaеive Energy and Ecology volume 2 (82) pp. 104-108 (2010) F. Karpeshin, Yu. Magarshak “On the Possible Influence of Resonance Conversion on Formation of the Organic Structures” ; Springer, Proceedings of ARW NATO Environmental and Biological Risks of Nanobiotechnology, Nanobionics and Hybrid Organic-Silicon Nanodevices (Silicon vs. Carbon) 149-164 (2009) L. Gribov, V. Baranov, Yu. Magarshak “Is “Silicate Life” Possible?” ; Springer, Proceedings of ARW NATO Environmental and Biological Risks of Nanobiotechnology, Nanobionics and Hybrid Organic-Silicon Nanodevices (Silicon vs. Carbon) pp 1-8 (2009) I. Ruban, M. Sharipov, N. Voropaeva, Yu. Magarshak “Modern Risks of the Antropogenic Influence on Living Spieces: Nano-level Fluctuation”; Springer, Proceedings of ARW NATO Environmental and Biological Risks of Nanobiotechnology, Nanobionics and Hybrid Organic-Silicon Nanodevices (Silicon vs. Carbon) pp 353-378 (2009) Y. Magarshak, "Alpha-Particles And Pauli Principle In Bara Atom " Scientific Israel – Technological Advantages (SITA) v.10, No. 4, pp. 171-176 (2008). Y. Magarshak, “Superresonant Atom Model as an element of the united theory of matter”. Scientific Israel – Technological Advantages (SITA) vol. 10 pp.145-150 (2008) Y. Magarshak “The Role of Empirical Relation in the Process of ab initio Modeling in Chemistry”. Eastern European Journal of Enterprise Technologies Vol. 34 # 4/1 69-75 (2008) Y. Magarshak Ellectron-Nucleons Resonance Atom Model of valence bonds. J Nuclear Physics, v. 71 #5, pp 1-9 (2008) Y. Magarshak On the issue of completeness of the modern conception of atomic and molecular structure J. The old and new concepts of Physics v 3 (2008) 7 L. A. Gribov, Y.B. Magarshak, To the Problem of Formulation of Basic Principles in the Theory of the Molecular Structure and Dynamics Concepts of Physics vol.V Nr.2 p 191 (2008) Y.Magarshak To the problem of EPN-resonant mechanism of the stabilization of the structure of molecules Proceedings of Russian Academy of Sciences volume 415 №5 pp. 1-6 (2007) (Original Russian Text © Yu.B. Magarshak, 2007, published in Doklady Akademii Nauk, 2007, Vol. 415, No. 5, pp. 600–605) F.Bogomolov Y.Magarshak Chemical Elements as the States of I-particle. Scientific Israel-Technological Advantages, vol. 8, issue 3-4 (2007) Y.Magarshak epn-Resonances and Atom Structure J. of Nuclear Physics, to appear Y. Magarshak The Resonance Approach to the Formation and Structure of Atoms and Molecules. Biophysics, vol. 52 no. 1 pp.95-108 (2007) F.Bogomolov Y.Magarshak Chemical Elements as the States of I-particle; Scientific Israel-Technological Advantages (SITA) vol. 9, issue 1- 2 pp. 116-119 (2007) Y.Magarshak, To the problem of completeness of our understanding of the atom structure. Power and Knowledge N9, 61-62 (2007) Y.Magarshak, Resonance Atom Model and the Formation of Valence Bonds; Scientific Israel-Technological Advantages, vol 9 issue 1-2 2007, pp.112-114 F.Bogomolov, Yu.B.Magarshak, ‘ Complementary Algebra and Applications on Neural Nets’. Biophysics, to appear. G.Magarshak & Y. Magarshak, ‘Complementary Arithmetics in Molecular Biology, Physiology and Technology’, Biophysics, accepted. F.Bogomolov, Y.Magarshak, On commuting operators related to asymptotic symmetries in the atomic theory; Scientific Israel-Technological Advantages, vol 8, issues 1-2, pp. 161-165 (2006) Y.Magarshak, Complementarity as the universal principle. Ecology and life, 3(52) pp.1116 (2006) Y.Magarshak, "Four-Dimensional Pyramidal Structure of the Periodic Properties of Atoms and Chemical Elements", Scientific Israel - Technological Advantages vol. 7, No.1,2 , pp. 134-150 (2006) Y. Magarshak, A. Sakharov Creative Destruction, in book “Russia without the Soviet Union”, Moscow, Nauman publishing house pp 116-119 (2006) 8 Y.Magarshak, “The end of the Prometheus Era”, International Journal of the alternative energy and ecology (ISJAEE ) 2,2006 Yuri Magarshak Tabu of the evolution and tabu of the civilization ”, International Journal of the alternative energy and ecology (ISJAEE ) 3,2006 O.Figovsky, Y.Magarshak. Non-Waste Civiliztion: Utopia or Reality? Letters to Alternative Energy and Ecology Journal, volume 1 Issue 1, May 2005 O. Figovsky, Yu. Magarshak: Aims of mankind in thousand years to come (in Russian). Proceedings of XIII International Scientific-Practical Conference on Ecology and Health of Human Being; Utilization of Waste. Schelkino, Krym, Ukraine, 6-10 Jine, 2005, pp. 719.. О.Фиговский, Ю.Магаршак. Цели человечества в грядущем тысячелетии. Сборник научных статей 13 международной научно - практической конференции "Экология и здоровье человека. Охрана воздушного и водного бассейнов. Утилизация отходов. т.1. с.7-19. Харьков, 2005. Юрий Магаршак, Евгений Левич. Энергетические инварианты хомобиоценоза. Сборник научных статей 13 международной научно - практической конференции "Экология и здоровье человека. Охрана воздушного и водного бассейнов. Утилизация отходов. т.1. с.20-22. Харьков, 2005. Ю.Магаршак. Табу эволюции и табу цивилизации. Сборник научных статей 13 международной научно - практической конференции "Экология и здоровье человека. Охрана воздушного и водного бассейнов. Утилизация отходов. т.1. с. 167- 171. Харьков, 2005. Олег Фиговский, Юрий Магаршак. Безотходная цивилизация: утопия или реальность? Сборник научных статей 13 международной научно - практической конференции "Экология и здоровье человека. Охрана воздушного и водного бассейнов. Утилизация отходов. т.2. с. 148- 155. Харьков, 2005. Yu.Magarshak, The third and the fourth dimensions of the chemical elements periodicity, Biophysics, vol. 50 number 4 (2005) Yu.Magarshak To the problem of the influence of sun batteries power station on climate; Ecology and Life, 3, 44-45 (2005) Yuri Magarshak, To the Problem of Four-Dimensional Symmetries in the Properties of Chemical Elements; "Scientific Israel - Technological Advantages", volume 7, issue 1-2, (2005). Yuri Magarshak, Eugene Levich, Humanity Energy Consumption, Ecology and Life, №2, 42 (2005) 9 Yuri Magarshak and Eugene Levich Energy utilized by a human as a subject of industrial civilization and as a part of nature. ."Scientific Israel - Technological Advantages", volume 7, issue 1, (2005). Y.Magarshak, Intellectual Renaissance, Proceedings of Russian Academy of Natural Sciences.. - Т. 4. - № 2. - С. 65-68 (2004). O.Figovsky, Yu.B.Magarshak, "Altera Vitae Civilization: problems and perspectives" "Scientific Israel – Technological Advantages", vol. 6, No. 3, pp.1-9, 2004. -----------------------------------------------------------------Magarshak IuB. ‘Analysis of the dynamics of transitions in Leptomonas collosoma spliced leader RNA and a possible role of gaps upon splicing’. Biofizika. 1997 Nov-Dec; 42(6):1216-23. Magarshak IuB 42(4):855-63. ‘Dynamic superhelicity in vivo and in vitro’. Biofizika. 1997 Jul-Aug; Y.Magarshak, ‘Projective geometry of color vision, generating the field of complex numbers’, Biophysics, 41, 3, 734-743 (1996). L.H. Kauffman and Y.B. Magarshak, "Vassiliev Knot Invariants and the Sructure of RNA Foldings ". In book "Knots and applications".,World Sci.Pub., editor L.H.Kauffman, 343-394 (1995). T.Krause, Yu.Magarshak, H.Fishman and G.Bittner, ‘Membrane potential and input resistance are ambiguous measures of sealing of transsected cable-like structures’, Biophysical Journal, 68: 795-799 (1995). L.H. Kauffman and Y.B. Magarshak, "Graph Invariants and The Topology of RNA Foldings’. Journal of Knot Theory and its Ramifications., vol.3,No 3 (Special Issue): 233-245 (1994). G.N.Sarkisov, D.A.Tikhonov, J.Malinsky, Y.Magarshak,"Martinov-Sarkisov Integral Equation for the Simple Fluids ", Journal of Chemical Physics, 99, 5: 3927-3932 (1993). J. Malinsky, Y. Magarshak, A. Smolyar, and A. Lipman “Single-electron transfer in organic molecules “ The Journal of Chemical Physics Vol 98(5) pp. 3968-3971. March 1, 1993 G.N.Sarkisov, D.A.Tikhonov, J.Malinsky, Y. J.Magarshak, "Thermodynamics and structural properties of a fluid with the square well potential ", Journal of Structural Chemistry, 34,2: 88-95 (1993). 10 Y.Magarshak, C.Benham, J.Malinsky, L.Blumenfeld, "RNA secondary structure dynamics and the symmetry of nucleic vectors ", Biophysics, 37, 4 (1993). Y.Magarshak, J.Malinsky, "Single Electron Transfer in Organic Molecules", J. Chem. Phys., 98, 5: 3968-3971 (1993). G. Sarkisov, D. Tikhonov, J. Malinsky, and Yu. Magarshak Martynov–Sarkisov integral equation for the simple fluids J. Chem. Phys. 99(5) 3926 (01 Sep 1993) Y.Magarshak, "Double transpositions and the classification of RNA secondary structures ", Biophysics, 38, 5, 886-887 (1993). Y.Magarshak, "Quaternion Representation of RNA Sequences and Tertiary Structures ", BioSystems, Elsevier Science Publishers, 30: 21-29 (1993). A.Kister, Y.Magarshak, J.Malinsky, "The Theoretical Analysis of the Process of RNA Molecule Self-Assembly ", BioSystems, Elsevier Science Publishers, 30: 31-48 (1993). Y.Magarshak, C.Benham, "An Algebraic Representation of RNA Secondary Structures ", J.Biom. Str. & Dyns., Vol.10, 465-488 (1992). Yu. Magarshak, J.Malinsky,"A Three-Dimensional Periodic Table ", Nature, vol.360: 113-114 (1992). J.Malinsky, Y.Magarshak, "A Green's Function Approach to Long Range Electron Transfer in Macromolecules ", The Journal of Physical Chemistry, Vol.96, 7: 2849-2851 (1992). J.Malinsky, Y.Magarshak, L.Blumenfeld, "Kinetics of Eectron Transfer in Macromolecules ", Biophysics, 37, 5: 923-926 (1992). J.Malinsky, Y.Magarshak, "Electron Transfer in Macromolecules: Green's Function and Diagrammatic Techniques (Continued Fraction Representation) ", International Journal of Quantum Chemistry, 40, 25: 183-192 (1991). J.Malinsky, Y.Magarshak, A.D.Joran, "Diagram Techniques for Solving Schvinger-Dyson Equation: Electron Transfer Pathways in Biological Molecules ", J.Chem.Phys., 95, 1: 418-432(1991). V.Stefanov, Y.Magarshak, "Calculation of the production of entropy in the chain of single-substrate enzymatic reactions ", Biophysics, 28, 3: 560 (1983). 11 V.Stefanov, Y.Magarshak, "Computation of Entropy Production in a Chain of Enzymes ", Papers of All-Union Institute of Scientific and Technical Information, USSR, 804: 83-92 (1983). Y.Magarshak, O.Sokolov, M.Turbovich,"Spectral Analysis of Several Pseudo-Random Signals in Aqua Media ", Papers of polytechnic Institute, Leningrad, 2, 31:126-134 (1979). V.Stefanov.Y.Magarshak, "Description of the Relationship Between the Concentrations of Metabolites in a Polyenzyme System ", Biophysics, 24, 6: 1025-1028 (1979). Y.Magarshak,V.Stefanov,"Graphic Method for the Analysis of the Steady-State Kinetics of Multienzime Systems ", Journal of the Mol. Biol., 13, 2: 347-352 (1979). Y.Magarshak, "Use of a Graphical Method for Analysing the Course of Poly-Enzimatic Reactions ", Biophysics, 57:157-158 (1978). Y.Magarshak, O.Sokolov,"Correlational Analysis of Several Nonstationary Acoustic Signals in Aqua Media ", Papers of Polytechnic Institute, Leningrad, 3: 38-48 (1977). Y.Magarshak, M.Turbovich, V.Frolov, "Evaluation Error of Statistic Characteristics of Several Pseudo-Random Signals With Desctete Sampling", Papers of Institute of Electric Instruments,1: 123-130 (1976). Y.Magarshak, "Use the Methods of Group Theory for Analysing the Knetics of Enzymes with Symmetry ", Biophysics, 19, 2: 219-224 (1974). Y.Magarshak, M.Volkenstein, "Representations of the Enzyme Symmetry Group and Their use for Solving of Enzymological Problems ", Biophysics,19, 4: 619-623 (1974). Y.Magarshak, O.Sokolov, M.Turbovich,V.Frolov, "Evaluation error of statistic characteristics of several nonstationary random processes with discrete sampling ", Papers of the 7th All Union Symposium Representation methods and apparatus analysis of random processes and fields, Leningrad, 3: 160 (1974). M.Volkenstein, Y.Magarshak, "Diagrams of Enzyme Kinetics : Transformation rules ", Proceedings of the Academy of Sciences of the USSR, 210, 3, 717-720 (1973). 12 M.Volkenstein, Y.Magarshak, V.Stefanov, "Transformed Diagrams of Steady Enzymatic Reactions ", Biophysics, 17, 3: 392-398 (1972). M.Volkenstein, Y.Magarshak, V.Stefanov, "Group Theory Applied to the Solution of Kinetics Equations of Enzyme Reactions ", Proceedings of the Academy of Sciences of the USSR, 204, 2: 474 (1972). V.Stefanov, Y.Magarshak, M.Volkenstein, "Diagrammatic Method for Analyzing Ping-Pong Mechanisms of Enzyme Reactions ", Proceedings of the Academy of Sciences of the USSR, 205, 1: 248 (1972). M.Volkenstein, Y.Magarshak, V.Stefanov, "Analysis of Enzyme Mechanism by Graphic Method ", Proceedings of the Academy of Sciences of the USSR, 197, 4: 949 (1971). M.Volkenstein, Y.Magarshak, V.Stefanov, "Diagrams of Enzyme Systems which Contain Isozymes ", Proceedings of the Academy of Sciences of the USSR 197, 5: 1193 (1971). Y.Magarshak, "Application of the Diagrammatic Method to Enzyme Kinetics Problems ", Synopsis of theses, Leningrad State University (1971). B.Goldstein,Y.Magarshak,M.Volkenstein,"Graphical Method of Analysis of Multienzyme Reactions ", Proceedings of the Academy of Sciences of the USSR,191, 5: 1120-1123 (1970). Y.Magarshak, M.Volkenstein, "Rate Formula Using Potential diagrams of Enzymes with Several Exit Paths ", Proceedings of the Academy of Sciences of the USSR, 192, 3: 665 (1970). M.Volkenstein, Y.Magarshak, "Application of the Diagrammatic Method of Solving Kinetic Equations of Cyclic Enzymatic Reactions ", Biophysics,15, 6: 983-993 (1970). M.Volkenstein, Y.Magarshak,"Diagrammatic Method of Solving the Problems of Steady-State Enzymatic Kinetics ", Biophysics,15, 5: 805-813 (1970). 13