OM & Ernährung 2013 | No. 143
Autoimmune Diseases –
New Therapy Approaches
So they reach each part of the body, they bind to
Introduction
target structures of the autoimmune reaction and
overreaction of the immune system against the
mark those cells as having to be eliminated by
body’s
system
phagocytes and CD 8 T-cells, which then leads to
erroneously recognizes endogenous tissue as “non-
the destruction of the respective organ (like in
self” and attacks it, causing severe inflammatory
multiple sclerosis).
reactions, which may lead to damages in various
Also specific pathogens, like bacteria (streptococci)
organs.
are able to do this (like in rheumatoid fever). This
diseases
own
tissues.
are
caused
The
by
immune
the
can be seen in serological auto antibody titers (as
recognition and the defense of microorganisms,
e. g. ANA, ANCA, anti phospholipid antibody) and
viruses, foreign substances (like chemicals and
also
metals), here specifically “trained” T-cells are
complexes.
The
Dr. med. Ursula Jacob
their specific antigens, these antigens dock with the
an
Autoimmune
immune
system
is
responsible
for
in
the
amount
of
circulating
immune
playing an important role.
In
autoimmune
diseases
the
T-cells
react
Standard Therapies
abnormally by recognizing body-own structures as
There is no possibility for a causal therapy, as the
“non-self”, i. e. they attack endogenous tissues,
exact triggers cannot be defined.
whereas the repair mechanisms of the body try to
The disease can only be treated symptomatically
regenerate
(immune suppression, anti-inflammatory) in the form
damaged
organ
parts
wherever
of cortisone or, most recently, with antibodies.
possible.
Without
treatment
this
process
will
continue
throughout the lifecycle or until the complete
Alternative Therapies
destruction of the organ.
As already mentioned, there is discussion of various
There are various hypotheses about the cause of
triggers
this disease:
autoimmune disease, like
 genetic disposition in combination with external
 too little exposition to environmental bacteria
encourage
the
development
of
an
viral
 Environmental
be
able
intoxification
to
cause
through
an
heavy
dental fillings, like mecury, arsenic, aluminium,
etc.
 Chronic inflammatory problems like bacterial/
autoimmune disease
 chronic
might
metals, which still are main components of
impacts (like stress, infections, etc.)
could
which
infections
and
unfavorable
viral burdens and allergies.
 Stress related problems which may lead to a
environmental influences
metabolic
dysfunctions
and
an
immune
Through the autoimmune reaction auto-antigens, cell
suppression due to depressed adrenal gland
membrane particles (micelles), DNA fragments or
function.
endogenous proteins are circulating in the body’s
Therapy Options with Natural Substances
blood stream.
L-lymphocytes and other immune cells erroneously
recognize
inflammation
them
as
promoting
“non-self”
and
substances
(so
express
called
cytokines) and disturb the cell communication (like
IL-6, IL 8, TNF α etc.).
More and more immune cells are attracted and the
false information is carried on. B-cells differentiate
to plasma cells and begin to produce autoantibodies which are released into the blood
stream.
For some time now, there have been therapeutic
approaches to treat autoimmune diseases with natural
substances. Well known is the therapy in Hashimoto’s
(autoimmune disease of the thyroid gland) with selenium
[Journal of clinical endocrinology and metabolism 87(4):1687–
1691, 2002].
Also incense preparations (boswellia carterii) are
given, for example in rheumatoid arthritis. These
prevent chronic inflammatory reactions in the body,
but show no effect in acute inflammations.
Disease
Affected Organ Tissue
Alopecia areate
Hair
Autoimmune enteropathy
Small and larage intestine enterocytes
Autoimune hepatitis
Liver
APECED
Pancreas, adrenal cortex, thymus
Bullous pemphigoid
Chronic gastritits
Hemidesmosomes of basal
keratinocyte
cells of skin, also often mouth mucosa
Stomach
Churg-Strauss syndrome
Vessels
CIDP
Colitis ulcerosa
Myelin layer of nerves of the
peripheral
nerve system
Large
intestines or rectum
systems, disturb the metabolism, hormones and the
Darmatomyositis
Cutaneous muscles
function of the adrenal glands, a therapy success can
Diabetes mellitus type II
Beta cells of the pancreas
unfortunately not be achieved by one substance
Dermatitis herpetiformis
Duhring
Epidermolysis bullosa
acquisita
Skin, small intestines
Glomerulonephritis
Kidneys
Goodpastuere syndrome
Basal membranes of kidneys and lung
Guillain-Barré syndrome
Myelin layer of nerves of the
peripheral nerve system
Thyroid gland
They inhibit in a reversible manner 5-lipoxygenase
and thus stop part of the inflammation cascade. They
also suppress NF-kb activation, which is responsible
for chronic inflammatory reactions. Through this they
have a positive effect on the involved pain symptoms.
Vitamin E, primrose oils, omega 3/6 as well as other
antioxidant combinations can influence detoxification
and regeneration ability of the damaged organs.
New Therapy Approaches
As autoimmune diseases affect complete organ
alone, but only by an appropriate combination of
different substances.
In order to determine these substances, we must get
an overview of the immune status, the metabolic
condition and the hormonal function.
For this we determine individual profiles in specialized
laboratories, like

Skin, small intestines
Hashimoto's thyroiditis
Idiopthic thrombozytopenic
purpura
Lichen sclerosus
Thrombozytes
Lichen Mucosae
Mucosa
ANCA and parameters related to the affected
Linear IgA dermatosis
Skin, small intestines
organs.
Lupus erythematodes
Inner organs and skin
Microscopic polyangiitis
Skin, kidneys, lung
Adamantiades-Behҫet
syndrome
Skin, iris
Grave's disease
TSH receptors of the thyroid
Crohn's disease
Intestinal tract
Inflammatory cytokines panel (interleukins, like
6, 8, 12, 10, etc.) as well as TH17-inflammtion,
detailed immune status.
 Also circulating immune complexes,
ANA,
 Amino acids, fatty acids, essential vitamins,
antioxidants and minerals.
 Possible
triggers
like
heavy
metals,
intolerances, viruses, etc..
Skin, small intestines
Depending on the results, an individual micronutrient
Case study
combination is prepared for the patient to achieve a
Patient AL.K.H. male *16.4.52
metabolic balance. This is combined with different
Patient has chronic viral load, prediabetes
detox therapies and targeted antiviral therapies.
Therapy until now: fermented soybean products,
To support these micronutrients we use regenerative
therapies employing different peptides (according to
As a specific therapy option to influence pathological
(chronic
Results: to date – decrease in ANA,
no new infections
organ specificity).
cytokines
Q10, minerals
inflammation),
autoimmune
Lab parameters
9/12
1/13
4/13
IL-8 pg/ml < 35
20,7
53,1
21
IL-6 pg/ml < 2
3,5
1,6
1
has a targeted influence on interleukin-6, -8, NK-cells
TNF-α pg/ml < 1
0,1
1,6
0,1
and TNF-alpha, as you can see in the following table.
NK absolute
complexes and the immune system, an extract from
fermented soybeans was examined and given, which
61
66
122
k.M
0,04
per ml >100600 sen
CRP
mg/dl < 0,3
0,7
OM Et Ernährung 2013 | No. 143
Abb. 1 Nutrition 2013 Feb;28(2):154-9. Doi: 10.1016/j.nut2011.05.008. Epub
o1^ antenurc
K
2011Aug26170Durc
Effects170
of soybean on immune
162 function, brain function, and
neurochemistry in healthy volunteers.[Yimit D, Hoxur P, Amat N,
150
40
Uchikawa
K, Yamaquchi
N. Research Institute, Xinjiang Medical
MesswMsw f
University,
Urumqi,
People’s
Republic of China]
140
160160
130
ereUnsereBeobachtungsergebnisse:Beobachtungsergebnisse:
DurchschniMliche* CRP sens. RedukNon
lich
D
0 ,5 5
0 ,u6
1 62
1 40
1 40
Messwert Ende
1 30
1 20
F36
0
Behandlungsdauer 6-­­8 Monate
70 Durchschnittlicher*
162 Anstieg NK Zellen
162
B
g/mpg
Be
The
e
20
hat
s15d
Messwert Anfang
Messwert Ende
Behandlungsdauer 6-­­8 Monate
DurchschniMliche*männl.16.4.52 IL6RedukNon
15,3
Ve
ti
4150
Messwert Messwert
l6
g/m
p
5160
De
140
3140
AnfangEnde
Messwert Ende
dat
10
te5
3,48
ab
2130
kinVknuee6i
u
I
nr
lu
t
e
r
l
ke
6170
0 ,2 5
0,2
1^ Uapenten
120
1^ Patienten
0,4
It
n
NK--‐ ZelenNK-­Zelen absolut
absper100perml10
1^ BUapenten
e
eob a
Messwert Anfang
I
per 100 ml
1 60
NK-­­ Zellen
1 5 0a bsolut
PCRP
senssensmg/dl mg/d l
DurchschniMlicher* AnsNeg NK Zellen
1 70
Behandlungsdauer 6--‐ 8 Monate
rlu
kn
ter
IL8 pg/
1^ Uapenten
le
La
0
Behandlungsdauer
6-­­8 Monate
1
Messwert Anfang
Messwert Ende
OM & Ernährung 2013 | No. 143
Conclusion
The fermented soybean extract proved to have a
positive influence on various autoimmune diseases
by down regulating the chronic inflammation and by
stimulating the immune system without any side
effects, also over an extended period of time. In
addition we could note decreasing autoimmune
parameters (like ANA, CIC, ANCA) and thus see a
marked improvement of the patient’s life quality.
Dr. med. Ursula Jacob
Geibelstrasse 15
81679 Munich | Germany
phone+49 (0)89.46229502
fax +49 (0)89.46223399
mobile +49 (0)160.7277580
info@doc-jacob.com
www.doc-jacob.com
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