TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKENUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME
TRANSLATIONAL CLINICAL RESEARCH
PARTNERSHIP (TCRP) GRANT CALL 2012 FOR
DUKE-NUS/SINGHEALTH ACADEMIC CLINICAL
PROGRAMME (ACP)
Grant Application Form
CLOSING DATE: 15 October 2012, 5pm
IMPORTANT: EVERY SECTION AND FIELD MUST BE COMPLETED.
PLEASE
INDICATE ‘NA’ WHERE A PARTICULAR SECTION OR FIELD IS NOT APPLICABLE.
INCOMPLETE APPLICATIONS WILL BE REJECTED.
Application must be submitted by the above closing date.
Also submit one duly signed original hardcopy to BMRC through your Office of
Research to:
Biomedical Research Council
20 Biopolis Way, Centros, #08-01
Singapore 138668
Tel: 68266111 Fax: 64789580
E-mail: chua_yee_cheng@a-star.edu.sg
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TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKENUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME
This document contains NINETEEN (19) separate sections.
Please complete ALL sections.
Please use Font: Arial 10 pt, SINGLE spacing for your text
SECTION
I.
DESCRIPTION
TITLE OF RESEARCH PROJECT
II.
FUNDING
III.
DETAILS OF CO-PRINCIPAL INVESTIGATORS (CO-PIs) AND COLLABORATORS
IV.
FIELD OF RESEARCH
V.
ETHICAL CONSIDERATIONS AND CONTAINMENT
VI.
SCIENTIFIC ABSTRACT OF PROPOSED RESEARCH PROJECT
VII.
LAY ABSTRACT OF PROPOSED RESEARCH PROJECT
VIII.
MAIN OBJECTIVES OF PROPOSED RESEARCH AND DESCRIPTION OF
PROJECT
IX.
VALUE OF THE COLLABORATION
X.
POTENTIAL APPLICATIONS/EXPLOITATION
XI.
DESCRIPTION OF PLANS FOR INTERACTION AMONG PERSONNEL INVOLVED
IN THE COLLABORATION
XII.
WORK CONTRIBUTION OF TEAM MEMBERS
XIII.
CURRICULUM VITAE
XIV.
BUDGET OUTLINE & JUSTIFICATIONS
XV.
MILESTONES AND PERFORMANCE INDICATORS
XVI.
OTHER SUPPORT
XVII.
SUGGESTED NAMES OF INTERNATIONAL REVIEWERS
XVIII.
DECLARATION BY CO-PRINCIPAL INVESTIGATORS
XIX.
ENDORSEMENT BY HOST INSTITUTIONS
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I.
TITLE OF RESEARCH PROJECT
II. FUNDING
Tier 1 capped at $1.5M/3 years (including 20% indirect costs)
Tier 2 capped at $3M/3 years (including 20% indirect costs)
Total amount of funds applied for : SGD
Period of Support requested :
(up to 3 years)
years
III. DETAILS OF CO-PRINCIPAL INVESTIGATORS (CO-PIs) AND COLLABORATORS
 Each proposal must involve a demonstrable collaboration between 2 Co-Principal
Investigators, at least one must be a faculty member holding a primary appointment at
Instructor level or above with Duke-NUS, and the other holding a primary appointment with a
SingHealth entity as well as a current or pending faculty appointment, either regular rank or
adjunct, with Duke-NUS.
 The Duke-NUS PI will be the designated primary point of contact for the collaboration to
coordinate submissions of progress and final reports.

The Co-PIs will be responsible for leading and managing a particular aspect of the
collaborative effort. His role will be to coordinate research activities carried out by the research
team.
A. Co-PIs
Title
Name
Research
Institution
E-mail
address
Contact
number
DUKE-NUS CO- PI
SINGHEALTH
ACP CO-PI
B. Collaborators
Any funding allocated to a Singapore-based collaborator needs to be accommodated within the
budget of a Co-PI. International collaborators are not entitled to receive (directly or indirectly)
any portion of the grant. Please add more rows if required.
1.
Title and name
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Email address and contact no.
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TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKENUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME
Postal Address
Role in proposed project
2.
Title and name
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Email address and contact no.
Role in proposed project
IV. FIELD OF RESEARCH
Neurology and Mental Health
Inflammatory and Infectious Diseases
Cardiovascular and Metabolic Diseases
Molecular Pathology and Biomarker Discovery
V. ETHICAL CONSIDERATIONS AND CONTAINMENT
Fund disbursement is subjected to ethics approval if the project involves any of the below.
(if yes, please state
all participating
institutions/centres)
Please tick accordingly if project involves any of the following:
a)
Human Subject
Yes
No
b)
Use of Human/Material/Animal Tissues or Cells
from Primary Donors (i.e. subject/volunteers
recruited for project)
Yes
No
c)
Use of Commercially Available
Material/Animal Tissues or Cells
Yes
No
d)
Animal Experimentation
Yes
No
e)
Requirement for Containment
Yes
No
f)
Multi-centre trials(s)
Yes
No
Human
A copy of the ethics approval is attached:
Yes
No
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VI. SCIENTIFIC ABSTRACT OF PROPOSED RESEARCH PROJECT
In no more than 300 words, concisely describe the specific aims, hypotheses, methodology and
approach of the research proposal including its importance to the furtherance of medical science,
in particular clinical significance. The abstract must be self-contained so that it can serve as a
succinct and accurate description of the research proposal. Note that the scientific abstract
may be disclosed to other funding agencies.
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VII. LAY ABSTRACT OF PROPOSED RESEARCH PROJECT
In no more than 300 words, concisely describe the specific aims, hypotheses, methodology and
approach of the research proposal including its importance to the furtherance of medical science,
in particular clinical significance. The abstract must be self-contained so that it can serve as a
succinct and accurate description of the research proposal. Note that the lay abstract may be
disclosed to the media for the purpose of the announcement of the grant call results.
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VIII. MAIN OBJECTIVES OF PROPOSED RESEARCH AND DESCRIPTION OF PROJECT
 List main objectives in order of priority.
 Describe the project clearly and succinctly
 Describe the main methodology and innovative approaches.
 Please do NOT exceed seven (7) pages for this section. Page limit excludes the reference
section.
Aim
Hypothesis
Methodology
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IX. VALUE OF THE COLLABORATION
Demonstrate how the research could not be done without the joint inputs of all the Co-PIs in this
research team for the full term of the project.
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X. POTENTIAL APPLICATIONS/EXPLOITATION
State clearly the likely applications of the work (technological, social, scientific, and economic) and
when these applications are likely to occur.
Technological –
Social –
Scientific –
Economic –
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XI. DESCRIPTION OF PLANS FOR INTERACTION AMONG PERSONNEL INVOLVED IN THE
COLLABORATION
 Briefly describe the plans for interaction among the team member(s)
 Include a qualitative description of the team member(s)’ commitment to the project.
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XII. WORK CONTRIBUTION OF TEAM MEMBERS
Provide the expected percentage effort within the project, as well as within his/her other work
commitments for the Co-PIs and Collaborator(s). Each Co-PI must have a minimum of 30%
effort within this project, and this should be reflected in the total project’s budget.
Name
Role in project (e.g.
Co-PIs and
Collaborators)
Institution
% effort within
project1
Total
100%
% effort within
own work
commitments2
1
NOTE: Represents percentage effort spent by the team members in the project relative to his/her other team
members. The total in this column must add up to 100%.
2 NOTE: Represents percentage effort spent by the team members on this project out of total work commitments
(eg. other grants, other teaching and administrative responsibilities, clinical work, etc).
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XIII. CURRICULUM VITAE
In no more than 1 page per team member, please provide the following information on all the CoPrincipal Investigators and Collaborator(s):








Name
Current position and past employment history (Please provide full details, eg, joint
appointments, percentage of time spent in Singapore every year, if applicable)
Academic qualifications (indicate institution’s name and year degree awarded)
Latest 10 publications
Patents held (related or unrelated to study)
Recent awards (Scientific awards)
Current and previous support from A*STAR/BMRC/NMRC/NRF or other sources
Research outcomes from other grants (e.g. publications, patents, awards, etc.)
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XIV. BUDGET OUTLINE & JUSTIFICATIONS
Instructions:
A. State the estimated funding required for the proposed research under each of the Co-PIs for
categories listed in the table below. Any funding allocated to a Singapore-based collaborator
needs to be accommodated within the budget of a Co-PI. International collaborators are not
entitled to receive (directly or indirectly) any portion of the grant.
1. Duke-NUS Co-PI’s Budget
Manpower (EOM)
Qualifications
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Research Fellow
Research Assistant
Research Nurse
Laboratory
Technician
Others (Please
specify)
EOM Sub-total
Equipment (please state)
Capped at a total of $100k
Equipment Subtotal
Other Operating Expenses (OOE)
Materials & Consumables
(Capped at $35k/Research Personnel/year)
Animal Cost
Local Conferences
Maintenance
Publications
Others (please state)
OOE- Overseas Travel
Overseas Travel
(This is capped at $6k/year and includes
overseas conference travel & overseas travel
for purposes directly related to the research
project)
OOE Subtotal3
GRAND TOTAL
3
OOE Subtotal should include that of OOE and OOE- Overseas Travel expenses.
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2. SingHealth ACP Co-PI’s Budget
Manpower (EOM)
Qualifications
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
PI EOM4
(capped at $100K)
Research Fellow
Research Assistant
Research Nurse
Laboratory
Technician
Others (Please
specify)
EOM Sub-total
Equipment (please state)
Capped at a total of $100k
Equipment Subtotal
Other Operating Expenses (OOE)
Materials & Consumables
(Capped at $35k/Research Personnel/year)
Animal Cost
Local Conferences
Maintenance
Publications
Others (please state)
OOE- Overseas Travel
Overseas Travel
(This is capped at $6k/year and includes
overseas conference travel & overseas travel
for purposes directly related to the research
project)
OOE Subtotal5
GRAND TOTAL
4
5
EOM will be funded proportionate to the amount of time spent on this project within own work commitments.
This EOM component is capped at 30% of current salary or $100k/year; whichever is lower.
OOE Subtotal should include that of OOE and OOE- Overseas Travel expenses.
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TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKENUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME
B. Provide the details and justifications why these items are critical for the success of the
research project:
 Proposed budget for PI EOM
 Equipment (where cap has exceeded $100k or if Co-PIs wish to pool equipment budget to
purchase equipment
 OOE for consumables exceeding the cap of $35k/research officer hired in the grant/year;
animal costs and maintenance.
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TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKENUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME
XV. MILESTONES AND PERFORMANCE INDICATORS
A. Propose detailed scientific milestones for the research proposal. These will be used to assess
the progress of the study. The progress of the project will be taken into consideration for
continued disbursements of funds.
Research
Milestones/
Deliverables
Q1
Year 1
Q2 Q3
Q4
Q1
Year 2
Q2 Q3
Q4
Q1
Year 3
Q2 Q3
Q4
Duke-NUS Co-PI
Milestone 1
Milestone 2
Etc.
SingHealth ACP Co-PI
Milestone 1
Milestone 2
Etc.
*Please use shading for the time points
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Research
Milestones/
Deliverables
Q1
Year 1
Q2 Q3
Q4
Q1
Year 2
Q2 Q3
Q4
Q1
Year 3
Q2 Q3
Q4
Collaborator (1)
Milestone 1
Milestone 2
Etc.
Collaborators (2)
Milestone 1
Milestone 2
Etc.
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B. Indicate the final expected targets for proposed research project. Please state ‘NA’ where
indicator is not applicable.
Performance Indicators
Capability
Indicators
Training R&D
manpower for
industry
Developing
long term R&D
capability
Number /
value
Master’s research students trained
PhD students trained
Master’s research and PhD students trained and
spun out to local industry as RSEs 6
Research staff spun out to local industry as RSEs
Post-doctoral (within 3 years of the PhD award)
researchers hired
Joint programs/projects with prestigious international
research organisations
Joint programs/projects with local universities
Invention disclosures
Proof-of-concept studies in man
Progress to Clinical trials
Kick-start clinical treatments/therapeutics
Patents filed/granted/licensed/commercialized
Papers published in international journals
(To state impact factor)
Presentations at international conferences
Industry
Relevance
Indicators
R&D
collaboration
Outcomes
External awards for research at international level
R&D projects with industry cash funding
Industry dollars received to fund R&D projects
( includes in-kind contribution )
Revenue from royalties and licensing agreements
Spin-off companies registered
New products/processes commercialized
6
RSE: Research Scientist and Engineer
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TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKENUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME
XVI. OTHER SUPPORT
Provide the following details for the grants currently held or being applied for by the Co-PIs.
A. Grant Support
Provide the details for all currently held or applied grants by the Co-PIs. These include those
supported by / applied to BMRC, NMRC, Universities, Clusters and other public funding agencies.
Attach the scientific abstract of each grant listed below for Council’s reference.
Title of Research
Funding
Agency
TCRP DUKE-NUS/SINGHEALTH ACP
Amount of Fund
Approved/
Received ($)
Balance
Available ($)
Support
Period
(Year)
Expiry
Date of the
grant
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TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP FOR DUKENUS/SINGHEALTH ACADEMIC CLINICAL PROGRAMME
XVII. SUGGESTED NAMES OF INTERNATIONAL REVIEWERS
Suggest names of reviewers who may be suitable to review the proposed project, and state the
relationship with the PI(s). Reviewers who are co-authors with the PI(s) in publications are
generally not to be included. Note that reviewers must not have conflict of interest or
involvement (direct and indirect) with the proposed project. BMRC has the final discretion
whether to select the suggested reviewers for the evaluation of the grant proposal.
S/N
Title
Names of Reviewers
Details of contacts
(Please provide mailing address,
e-mail address, tel and fax numbers.)
Relationship to
Principal
Investigator
1
2
3
4
5
The application should not be sent to the following reviewers.
1)
2)
3)
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XVIII.
DECLARATION BY CO-PRINCIPAL INVESTIGATORS
We declare that the facts stated in this application and the accompanying information are true and
that this is an original proposal. In signing the Grant Application, we UNDERTAKE, on any Grant
Award, to the following:







Not send similar versions or part(s) of this proposal to other agencies for funding.
Submit supporting documents of ethics approval obtained from the relevant Institutional
Review Board (IRB) and Animal Ethics Committee for studies involving human
subjects/human tissues or cells, and animals/animal tissues or cells respectively.
Be actively engaged in the execution of the research and comply with all laws, rules and
regulations pertaining to animal and human ethics, including the Singapore Good Clinical
Practice guidelines.
Ensure that BMRC’s funding is acknowledged in all publications.
Ensure that all publications arising from research wholly or partly funded by BMRC will be
forwarded to BMRC.
Co-operate with BMRC to develop interests in biomedical sciences among students and
teachers.
Obtain approval from BMRC before engaging in any commercial activity that will exploit the
findings of the research funded by Council.
Signature
Date
Duke-NUS
Co-Principal Investigator
SingHealth ACP
Co-Principal Investigator
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XIX.
ENDORSEMENT BY HOST INSTITUTIONS
In signing the Grant Application, the Institution UNDERTAKES, on any Grant Award, to:
 Provide appropriate support during the grant period.
 Ensure that the funds provided are used for the appropriate purposes.
 Ensure that the study complies with all laws, rules and regulations pertaining to animal and
human ethics, including the Singapore Good Clinical Practice guidelines.
 Ensure that approval from BMRC has been obtained before engaging in any commercial
activity that will exploit the findings of the research funded by the Councils.
 Have in place a code of practice for research integrity and procedures to deal with unethical
research practices.
Name and Signature
Date
Head/Director of Dept of Duke-NUS
(pls specify):
Head/Director of Dept of SingHealth
Institute (pls specify):
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