Prof. Rudresha Kottani
Education:

Ph.D. in Pharmaceutical Chemistry “ Chemical and Biological Studies of Natural and
Synthetic Products”. Gulbarga University, India (2000).

M.Sc.
in
Pharmaceutical
Chemistry
“Pharmacological
activities
of
Justicia
procumbens”, Gulbarga Univesity, India (1994).

B.Sc. In Chemistry, Physics and Mathematics, Gulbarga University, India (1991).
Professional Experience:
Research Scientist:
Department of Chemistry,
(06/06---Current) University of Arizona, Tucson, AZ, USA
Sponsor: NSF, USA
In fast-paced environment, working on the project which involves the development of catalyst
for the production of Hydrogen (Green Chemistry). Synthesized a series of nitrogen
heterocycles (bipyridine systems) for the studies in developing a catalyst for Hydrogen
production. Developed and introduced new techniques of synthesis to improve the yields of
the target molecules.
Post Doctoral Research Associate:
Department of Chemistry,
(01/2004---06/2006)
University of Denver, Denver, USA
Sponsor: NSF, USA
In a dedicated and result oriented lab, involved in the synthesis of photolabile adducts
(xanthones, thioxanthones, benzophenones, dithianes). These molecules were successfully
employed and played a critical role to develop a promising methods in combinatorial library
screening, drug delivery and fluorescence applications. I made major contributions in
developing a method for screening of solution phase combinatorial libraries. This method is
considered as novel and helps to overcome the difficulties in screening combinatorial libraries.
Post Doctoral Fellow:
Department of Chemistry,
(01/2002---12/2003) National Chung Cheng University, Taiwan (R.O.C)
Sponsor: Auspex Pharmaceuticals, USA
In an industry sponsored project, engaged in developing a efficient, cost-effective synthetic
strategy to prepare building blocks which are of industrial use. Designed and synthesized
large number of molecules (deoxysugars, deoxyazasugars) in an efficient way to obtain
stereodivergent, enatiomerically pure organic intermediates. These compounds are now being
employed in pharmaceutical industry for the synthesis of target molecules for anti-viral
deceases.
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Professional Honors:
British Council Fellowship (1999)
British Council Fellowship (1997)
Research Fellow of AICTE, India
University Merit Studentship
Research Summary:
Involved in the Design and Synthesis of Organic molecules which are employed in
Pharmaceutical,
Agrochemical, Cosmeceutical, Combinatorial, Green Chemistry and
Industrial applications.
Publications:

Published Papers:

“In Vitro Cytotoxic Properties of O-methylsolanocapsine Isolated from Solanum
Pseudocapsicum Leaves”, Santoshkumar H. Dongre, Shrishailappa Badami, Godavarthi
Ashok, S. Ravi and Rudresh Kottani, Indian J Pharmacol, 39(4), 208-209 (2007).

“Direct Screening of Solution Phase Combinatorial Libraries Encoded with Externally
Sensitized Photolabile Tags”, Rudresha Kottani, Roman A. Valiulin and Andrei G.
Kutateladze,
Proc. Natl. Acad. Sci. USA, 103 (38), 13917-13921 (2006). 

“Photoinduced Signal Amplification Through Controlled Externally Sensitized
Fragmentation in Masked Sesitizers”, Rudresha Kottani, Janaki R.R. Majjigapu, Alexei
N. Kurchan, Kavitha Majjigapu, Tiffany P Gustafson and Andrei G. Kutateladze, J. Am.
Chem Soc., 128 (46), 14794-14795 (2006).

“When Ethyl is Infinitely Different from Methyl: Double Addition of Lithiated Dithianes
to Aromatic Carboxylates Revisited”, Roman A. Valiulin, Rudresha Kottani and Andrei
G. Kutateladze, J. Org. Chem, 71 (13), 5047-5049 (2006).

“Release and Report: A New Photolabile Caging System with a Two-photon
Fluorescence Reporting Function”, Janaki R.R. Majjigapu, Alexei N. Kurchan,
Rudresha Kottani, Tiffany P. Gustafson and Andrei G. Kutateladze, J. Am. Chem Soc.,
127 (36), 12458-12459 (2005).

“Efficient and stereodivergent synthesis of deoxyimino sugars”, Bor-Cherng Hong,
Zhong-Yi Chen, Arumugam Nagarajan, Rudresha Kottani, Vishal Chavan, Wie-Hung
Chen, Yea-Fen Jiang, Shuo-Cang Zhang, Ju-Hsiou Liao and Sepehr Sarshar., Carbohydr.
Res. , 340, 2457-2468 (2005).

“Efficient synthesis of enantiomerically pure dihydropyrans”, Bor-Cherng Hong, ZhongYi Chen, Arumugam Nagarajan, Kottani Rudresha, Vishal Chavan, Wie-Hung Chen,
Yea-Fen Jiang, Shuo-Cang Zhang, Gene-Hsiang Lee and Sepehr Sarshar., Tetrahedron
Letters, 46,1281-1285 (2005).
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
“Dithiane, Trithiane and Dithiazine- Based Photolabile Scaffolds for Molecular
Recognition: Mechanism and Efficiency of the Photoinduced Fragmentation in Aqueous
Reductive Environments”, Andrei Kutateladze, Rudresha Kottani, Alexei Kurchan,
Janaki Ramreddy Majjigapu and Sam Shrik, Phosph. Sulf. Silicon, 180, 1379-1384
(2005).

“Synthesis and biological activities of new 5-hydrazino-10-substituted-7H-indolo [2,3methyl pyrazol-5-ones and -3,5-disubstituted pyrazolines", S.P.Hiremath, K.Rudresh and
A.R. Saundane, Indian J Chem, 41B (2), 394-399 (2002).

“Post-coital antifertility activity of Acalypha indica L.”, S.P.Hiremath, K. Rudresh,
Shrishailappa Badami, Somnath R. Patil and Saraswathi B. Patil, J. Ethnopharmacology,
67, 253-258 (1999).

“Antiimplantation activity of alcoholic(95%) extract of Rivea hypocrateriformis”,
H.Shivalingappa, J.S. Biradar and K. Rudresh, Indian J. Pharm. Sci., 61(5), 309-310
(1999).

“Synthesis and Pharmacological Screening of some N1-substituted phenyl-N3-(21substituted indole-31-methine) thioureas”, A. R. Saundane, G. Prayagraj, S.H. Ranganath
and K. Rudresh, Asian Journal of Chemistry, 10(4), 856 (1998).

“Synthesis and Pharmacological Studies of Some New 11H-indolo[3,2-c]isoquinolin-5-ylthio acetylthiosemicarbazide and its Derivatives”, A.R. Saundane, S.H. Ranganath, G.
Prayagraj, K. Rudresh and N.D. Satyanarayana, Oriental Journal of Chemistry, 14(2),
251-254 (1998).

“Pharmacological Screening of 6H, 11H-indole[3,2-c]isoquinolin-5-ones and their
derivatives”, A.R. Saundane,
K. Rudresh, N.D. Satyanarayana and S.P. Hiremath,
Indian J. Pharm. Sci., 60(6), 379-83 (1998).

“Flavonoids of Acalypha indica L.”, S.P. Hiremath, K. Rudresh and Shrishailappa
Badami, Indian J. Het. Chem., 8, 163-164 (1998).

“Antiinflammatory Activity of Alcohol Extract of Justicia procumbens (Acanthaceae)”,
B.H.M. Mruthyunjayaswamy, K. Rudresh, H.K.S. Swamy, S.M. Badami and S.P.
Hiremath, Indian J. Pharm. Sci., 60(3), 173-75 (1998).

“Anti-microbial Activity of Various Extracts of Striga sulphurea and Hemidesmus
indicus”, S.P. Hiremath, K. Rudresh and Shrishailappa Badami, Indian J. Pharm. Sci.,
59(3), 145-147 (1996).
Patents:

“Method for Encoding and Screening Combinatorial Libraries”. Rudresha Kottani,
Roman A. Valiulin, Janaki R.R. Majjigapu and Andrei G. Kutateladze, WO2007070761
A2 , 79pp (2007).

“Photoinduced signal amplification through externally sensitized photofragmentation in
masked
photosensitizers”. Andrei G. Kutateladze, Alexei N. Kurchan, Rudresha
Kottani, and Janaki R.R. Majjigapu, WO2007008472 A2, 42pp (2007).
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
“Photolabile system with instantaneous fluorescence reporting function”. Andrei G.
Kutateladze, Alexei N. Kurchan, Rudresha Kottani, and Janaki R.R. Majjigapu,
WO2007008471 A2, 35pp (2007).

“Method of Preparation of Heterocyclic Molecules with Pharmaceutical, Pharmaceutical
Excipient, Cosmeceutical, Agrochemical and Industrial Uses”, Bor-Cherng Hong, ZhongYi Chen, Arumugam Nagarajan, Kottani Rudresha, Vishal Chavan and Sepehr Sarshar,
US 2006/0173199 A1, 83pp (2006).

“Method of Preparation of Heterocyclic Molecules with Pharmaceutical, Pharmaceutical
Excipient, Cosmeceutical, Agrochemical and Industrial Uses”, Bor-Cherng Hong, ZhongYi Chen, Arumugam Nagarajan, Kottani Rudresha, Vishal Chavan and Sepehr Sarshar,
WO 2004/064745 A2, 209pp (2004).
International Conferences:

“Pharmacological activities of Justicia procumbens” S.P.Hiremath, H.K.S.Swamy, S.
Badami, K. Rudresh and B.H.M. Mruthyunjayaswamy was accepted for presentationin
the Eleventh Annual Conference of Indian Council of Chemists held at Bihar University,
Muzaffarpur from March 12-14, 1993 (Page No.65-66).

“Pharmacological screening of plant Evolvulus alsinoides”, S.P. Hiremath, B.K.
Shanthaveerappa, K. Rudresh and H.K.S. Swamy, was accepted for presentation in the
Eleventh Annual Conference of Indian Council of Chemists held at Bihar University,
Muzaffarpur from March 12-14, 1993 (Page No.66)

“Antibacterial and antifungal activity of various extracts of S. album, D. falcata and A.
farnisiana”, Suneel Beede, H. Gululingappa and K. Rudresh, was accepted and presented
at Fifteenth Annual Conference of Indian of Chemists held at Dr. B.S.A. Maratwad
University, Aurangabad from October 26-28, 1996 (Page No.13)

“Antifertility activity of Acalypha indica”, S.P. Hiremath, K. Rudresh and S.Badami, was
accepted and presented at the Fifteenth Annual Conference of ICC held at Dr.B.S.A
Maratwad University, Aurangabad from October 26-28, 1996 (Page No. 15-16)

“Estrogenic effect of Acalypha indica (Euphorbiaceae)”, S.P. Hiremath and K. Rudresh,
was accepted and presented at Sixteenth Annual Conference of ICC held at Mangalore
University, Mangalore from December 29-31, 1997 (Page No.13)

“Synthesis and pharmacological screening of some N1- substituted phenyl-N3-(21substituted indole-31-methine) thioureas”, A.R. Saundane, G.Prayagraj, N.D.
Satyanarayan, K. Rudresh, S.H. Ranganath and S.P. Hiremath, was accepted and
presented at Sixteenth Annual Conference of ICC held a Mangalore University, Mangalore
from December 29-31, 1997 (Page No.32-33).

“Antiulcerogenic activity of Acalypha indica (Euphorbiaaceae) on experimentally induced
gastric ulcer” N.D. Satyanarayan, K. Rudresh and M.G. Purohit, was accepted and
presented at the Sixteenth Annual Conference of ICC held at Mangalore University,
Mangalore from December 29-31, 1997(Page No.33).
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
“Analgesic activity of various extracts of plants Hemidesmus indicus (Asclepidiaceae) and
Striga sulphurea (Scrophulariaceace)”, J.S. Biradar, H. Shivalingappa and K. Rudresh,
was accepted and presented at the Sixteenth Annual Conference of ICC held at
Managalore University, Managalore from December 29-31, 1997 (Page No.34).

“Analgesic and anthelmintic activity of the plants Acalypha indica and Caeselpinia
bonducella” , S.P. Hiremath, M.S. Hallur and K. Rudresh, was accepted and presented at
the Sixteenth Annual Conference of ICC held at Mangalore University, Mangalore from
December 29-31, 1997 (Page No.34).

“Synthesis and pharmacological studies of some new 11H-indolo(3,2-c) isoquinolin-5-yl
thio) acetyl thiosemicarbazide and its derivatives”. A.R. Saundane , S.H. Ranganath, N.D.
Satyanarayan, G.Prayagraj, K.Rudresh and S.P.Hiremath, was accepted and presented at
Sixteenth Annual Conference of ICC held at Managalore University, Mangalore from
December 29-31, 1997 (Page No. 40).

“Isolation and structural study of the flavonoids from the plant Acalypha indica” , S.P.
Hiremath, and K.Rudresh, was accepted for the Indian Chemical Society’s 35th Annual
Convention of Chemists 1998 held at Karnatak University, Dharwad from November 4-7,
1998.

“Antiandrogenic effect of Acalypha indica” S.P. Hiremath and K. Rudresh, was accepted
for the Indian Chemical Society’s 35th Annual Convention of Chemists 1998 held at
Karnatak University, Dharwad from November 4-7, 1998.

“Estrogenic effect of Caeselpinia bonducella (Caeselpiniaceae)”, S.P. Hiremath, M.S.
Hallur and K.Rudresh, was accepted and presented at the Seventeenth Conference of ICC
held at University of Madras, Chennai from 26-28, November 1998 (Page No.01)

“Synthesis and pharmacological activities of some new indolo(2,3-c)isoquinolines”, A.R.
Saundane, K.Rudresh and S.P. Hiremath, was accepted and presented at the Seventeenth
Conference of ICC held at University of Madras, Chennai from 26-28, November 1998
(Page No.10).

“Isolation, structural study and hormonal properties of flavonoids of Acalypha indica”,
S.P. Hiremath, K. Rudresh and M.S. Hallur, was accepted and presented at the
Seventeenth Conference of ICC held at University of Madras, Chennai from 26-28,
November 1998 (Page No.19).

“Biological screening of Lucas aspera” , A.R. Saudane, K.M. Hidayatulla,
N.D.Satyanarayan and K. Rudresh was accepted and presented at the Seventeenth
Conference of ICC held at University of Madras, Chennai from 26-28, November
1998(Page No.19).

“Analgesic activity of various extracts of Atylosia scarabaeoides benth” Y.N. Seethram,
Vijay, C. Haleshi and K. Rudresh was accepted and presented at the Seventeenth
Conference of ICC held at University of Madras, Chennai from 26-28, November 1998
(Page No.49)
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
“Biological and pharmacological screening of 6H, 11H-indolo(3,2-c) isoquinolin-5-thione
and their derivatives”, A.R.Saudane, N.D. Satyanarayan, K. Rudresh and S.P. Hiremath,
was accepted and presented at the Seventeenth Conference of ICC held at University of
Madras, Chennai from 26-28, November 1998 (Page No.54)
Membership of Professional Bodies:

Member, American Chem Society

Member, American Association of Pharmaceutical Scientist

Active Member, American Association for Cancer Research

Member, Royal Society of Chemistry

Editorial Board Member, Asian Journal of Chemistry
Mailing Address: Departement of Chemistry, University of Arizona, 1306 E. University Blvd,
Tucson, AZ 85719, USA
Tel No. 520-621-4808 (Off)
Cell No. 303-332-5369 (Cell)
Email: rkottani@email.arizona.edu
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