The Indian Pharmaceutical Association PHARMA PROFESSIONAL Vol. 65 August 2011 With the growth rate of 14 percent per year, the Indian pharmaceutical industry is well established for rapid expansion. Indian Pharmaceutical Industry has made phenomenal progress over the years and made Inside the Issue its impact in the global market. It has been recognized as a reliable source for drugs and drug intermediates and pharmaceutical formulations. With the strengthening of the IPR scenario in the quarter ended December 31, 2005 witnessed major changes in the Indian pharmaceutical Incountry, Focus:theInnovatives and Emerging Trends of Anesthesia industry like the foreign MNCs increasing their presence in India through expansions and collaborations; Machines Indian companies competing with them through new product launches and gaining more number of News Briefapprovals. Many multinational companies have penetrated into India with an objective to regulatory marketing drugs and conducting clinical trials. Thus, Indian pharmaceutical research, manufacturing and Product Focus – Losartan outsourcing have received an impetus, thereby creating an image of a potential Pharma market and land of opportunities in the pharmaceutical division. Moreover the new Draft Drug Policy’ 2006 was released Stock Scan during this quarter. Upcoming Events In Focus: Innovatives and Emerging Trends of Anesthesia Machines Overview Anesthesia equipment is used in medicine to induce a temporary loss of sensation in the patient. The most common type of anaesthetic machine in use in the developed world is the continuous-flow anaesthetic machine, which is designed to provide an accurate and continuous supply of medical gases (such as oxygen and nitrous oxide), mixed with an accurate concentration of anaesthetic vapour (such as isoflurane), and deliver this to the patient at a safe pressure and flow. The anaesthetic machine is usually mounted on anti-static wheels for convenient transportation. Types of Anesthesia Equipments The type of equipment used depends on the type of anesthesia Special Machines being done and the medical procedure that the anesthetic is Datex-Ohmeda Excel 210 SE being used such as local and regional anesthesia. The anesthetic Dräger Narkomed 2C machines are Modern versions, which combine numerous Datascope Anestar elements that are necessary to safely deliver anesthesia, as well as monitor a patient's condition. The combining of numerous medical tools into one piece of anesthesia equipment translates into better patient care and fewer deaths. Continuous-Flow Anesthetic Machine: It is programmed to deliver an accurate, controlled and continuous level of medical gases, including oxygen, to the patient. It also delivers the gas/medication that causes the patient. Airway equipment: The Airway equipments include masks, endoscopes, tracheostomy tubes, endotracheal tubes, laryngoscopes and other items essential to the breathing function. Airway anesthesia equipment is critical, since the medication interrupts a person's normal breathing. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd. Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 1 Pharma Professional August 2011 Market Growth The anesthesia market is increasing rapidly with the growing safety awareness and technology enhancements in anesthesia machines. In china, the market potential of the anesthesia machines is huge, where the market is growing at an average rate of 8% to 10% per year. The major players in market are Draeger, GE health care, Philips health care, and Maxon medicals, which encompass high precision driven systems. The market may see a growing acceptance of automated anesthesia workstations. The surgery centers, which have less overhead and greater interest in modernizing and automating the OR, are more eager to embrace the technology. Major Players Hospitech Allied Medical Lifeline Medisys Blue Star Emerging trends There are few technological advances in endoscopy in India. At present we chiefly depend on imported products. New technologies in liquid handling systems from Eppendorf, Germany, would go towards improving and expanding the Indian market. Introduction of ultra light-weight, fully-autoclavable Research plus pipettes would provide comfort, precision, and accuracy that raise the user's expectations. Research plus pipettes with their ergonomics, flexibility, robustness, and the physiocare concept set the standards in the global liquid handling market. Challenges Faced by End-Users With the rapid advancements in the anesthesia industry, anesthesiologists sometimes find it difficult to keep up with anesthesia machine technology. The wide variety of designs available in the market leads to differences in how the ventilators work. The differences extend to the systems for generating pressure used by different manufacturers of each model, to the algorithms employed in the software, or the solutions proposed by each to compensate for certain deficiencies inherent to the design. Lack of uniformity prevents the anesthesiologist from meeting the ideal objective of working on a daily basis. Global Scenario The global anesthesia and respiratory Indian Anesthesia Equipment devices market is forecasted to exceed US$14 billion by 2016 with a Compound Market In 2011 Premium, Annual Growth Rate of 10% from 20091.9 2016. The market is expected to be primarily driven by the huge patient Value, population suffering from Obstructive 25.5 Sleep Apnea and Chronic Obstructive Performan ce, 50.5 Pulmonary Disease and the availability of medical devices to treat OSA and COPD. Mid-Tier, 35.5 Respiratory devices accounted for 55% of the overall anesthesia and respiratory devices market in 2009, making it the largest category. The Global market for anesthesia equipment market, including anesthesia delivery machines, anesthesia Source; Cygnus Market Resources device accessories, anesthesia monitors, and anesthesia information systems, is projected to grow at a CAGR of 7% to reach US$8.3 billion by 2015. Government Regulations There is no significant role of the Indian Government in the endoscopy market. However, though flexible and rigid endoscopes or cameras are not manufactured in India, the Government expects close to 10% customs duty for all the items imported in the segment. This poses as a major challenge for the manufacturers and vendors. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 2 Pharma Professional August 2011 Outlook Anesthesia machines are a very useful piece of medical equipment used by physicians, who specializes in anesthesiology to support surgeons and doctors who operate on patients. Many modern anesthetic medical equipment machines are available with a ventilator, suction unit, and patient monitor. Medical Machines Online provide with a variety of new and refurbished anesthesia machines and other reliable medical equipment for practice, clinic or other hospital needs. Anesthesia machine is one of the necessary medical apparatuses in the hospital. Presently, China requires about 5,000 units of anesthesia machines annually, including about 3,000 lower-end ones, which are mainly provided by China’s domestic producers, and 2,000 middle-to-high end ones, 80% of which are imported. The high-end anethesia market is almost monopolized by foreign brands. About US$30m is invested in importing middle-to-high end anesthesia machines annually. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 3 Pharma Professional August 2011 News Briefs Marketing Americas USA: Biotage introduces new microwave Peptide Synthesizer delivering higher reliability The Biotage Initiator SP Wave is a versatile synthesis solution as it could be used as a standalone peptide synthesizer or easily converted to a high specification MAOS system. It is the ideal development tool for chemists synthesizing peptides, peptidomimetics and small molecules using single or multi-step procedures. The Initiator SP Wave is perfectly suited for the small scale synthesis of peptides and peptidomimetics including PNA using microwave irradiation, from a scale as low as 5 µmol. The semiautomated operation could reduce the consumption and waste of expensive reagents which occur in other systems due to priming or use of large dead volumes. USA: High-Resolution imaging technology reveals cellular details of coronary arteries General Hospital developed a one-micrometer-resolution version of the intravascular imaging technology optical coherence tomography, which could reveal cellular and subcellular features of coronary artery disease. In a Nature Medicine paper receiving advance online publication, the investigators describe how microOCT, which provides 10 times greater resolution than standard OCT, was able to show individual arterial and inflammatory cells, including features that may identify vulnerable plaques, within coronary artery samples. MicroOCT has the contrast and resolution required to investigate the cellular and subcellular components underlying coronary atherosclerosis, the disease that precipitates heart attack. USA: Randox Life Sciences produce highly sensitive antibodies to a range of drugs Randox Life Sciences developed and manufactured a wide range of products including high quality, cost effective recombinant proteins, polyclonal antibodies and conjugates targeting drugs of abuse, steroids, hormones and biochemical markers. These specific life science products are manufactured at ISO 13485 certified manufacturing plant in the United Kingdom using state of the art facilities. It is now accepted that drug misuse is a large and growing problem affecting not only the user but society as a whole. Drug testing could provide a tool for detecting users and monitoring the compliance of subjects in recovery programs. Randox Life Sciences developed an extensive range of drug targeted antibodies for research and development applications. USA: Out Sourcing Manufacturing of Biopharmaceuticals Outsourcing manufacturing, once used mainly as a cost-reduction or capacity supplement strategy, is now increasingly being viewed as a risk-mitigation for operational excellence and growth strategy. Ensuring consistent quality and reliable delivery require companies to understand their vendors' and contractors' areas of expertise, pose good control over their supply chain networks, and boast a solid risk-management strategy in place. The conference would bring these critical elements together and offer case studies on strategies that will lead towards a successful agent-sponsor relationship, thereby ensuring consistent high quality products from CMO partners. USA: Verizon combines the power of 4G LTE tablet The Cisco Cius would be available to Verizon enterprise and government customers around the world later this summer, and those located domestically would be able to combine the device with a Verizon Wireless 4G LTE mobile hot spot. Designed for the enterprise, the Android-based Cisco Cius combines voice, video, collaboration and virtualization capabilities on one device. When powered by Verizon’s 4G LTE network, mobile workers would be able to easily use bandwidth-intensive video applications between devices for more effective collaboration. Mobile applications over intelligent high-speed networks would continue to eliminate barriers in the workplace. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 4 Pharma Professional August 2011 USA: Mayo Clinic launches its own social networking site Touting it as the first of its kind, Mayo Clinic last week launched its own version of a free, open social networking community. According to a Minnesota Public Radio article, in 2010, Mayo launched Center for Social Media to boost engagement between medical professionals and health systems. The newest social networking site promises to be unlike other existing medical group or hospital online communities. The people are not aware of other online communities created by a medical provider group or hospital system. USA: VA awards US$12 billion for Infotech work, including health IT The Department of Veterans Affairs (VA) is hoping to upgrade and transform its information systems through a series of 14 recently awarded contracts worth US$12 billion. Under the Transformation Twenty-One Total Technology program, known as T4, the VA would modernize all of its systems. The upgrade would encompass program management and strategy planning; systems and software engineering; enterprise network, test and evaluation; independent verification and validation; cyber security; operations and maintenance; and training and IT facility support. The VA is also in the process of upgrading its decades-old VistA EHR by using open-source technology. USA: JHP Pharma in pact to produce life saving drugs JHP Pharmaceuticals, a contract manufacturing service provider of sterile injectables and ophthalmic/otic products, signed a deal with a pharma firm for the production of a life-saving drug. JHP's Rochester Michigan manufacturing plant covers over 80 acres of land and includes a 171,000 sqft. production building and warehouse. JHP Pharma’s President and CEO said that their cGMP compliance record and experienced staff allow them to effectively serve the important customer. During the last six months, the company successfully completed FDA and EMA audits in addition to entering agreements with four new contract customers. Europe France: Roche establishes R&D institute in France Roche established a new research and development (R&D) institute in France under the lead of the company’s pharma research and early development (PRED) unit. The PRED French R&D Institute would be managed by a Roche academic team, which will be in charge of building new research networks with French academic partners, leveraging their expertise, technology platforms and scientific breakthroughs in areas of medical need. The Institute would serve for academic collaborations in France across multiple disease areas and scientific disciplines as oncology, neurosciences, metabolism, inflammation, virology, translational research and toxicology. Asia-Pacific India: Wipro launches cloud portal for clinical trials Wipro Technologies launched Wipro Clinical Collaboration Portal, a secure based productized solution. The service is aimed at helping Drug Development Owners (DDOs), Clinical Research Organisations (CROs) and regulators to improve collaboration for multi-region clinical trials. Wipro stated the new launch would reduce the clinical trial cycle time by 20-30% by speeding communication and document exchanges between CROs, regulators and DDOs. The Wipro Clinical Collaboration based portal is supported by Wipro's Rapid Trial framework and integrated with leading market products for electronic data capture, interactive voice recording system and others. India: AstraZeneca units delist move fails again Sweden-based AstraZeneca Pharma AB once again failed in its bid to delist its Indian subsidiary AstraZeneca Pharma India Pvt. Ltd. The parent holds almost 90% in the Bangalore outfit, which is listed on the BSE and the NSE. AstraZeneca Pharma India stated the delisting plan would not take place as the parent did not get the mandated number of public shareholder votes to buy back the remaining shares. The buyback offered through postal ballots was launched a month back, with a floor price of Rs576.10 a share and not exceeding Rs1,152. The Swedish parent tried a buyback in mid-2004 but gave up the plan as it found the exit price of Rs3,000 a share the outcome of reverse book-building too high. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 5 Pharma Professional August 2011 India: Focus on coir R&D to face competition The collective efforts to introduce cost-effective technologies in the micro, small and medium enterprises sector, especially in the coir industry, which employs about 5.5 lakh persons, a majority of whom are women. The technology, marketing, credit and skill development should be the major areas of focus for a sustainable and stronger growth of the sector. The MSMEs, especially from the traditional sector, are not cost-effective, which made their products vulnerable to competition from other sectors. India: JB Chem launches new biz division, shares rise J.B. Chemicals & Pharmaceuticals launched a new business division catering to gynaecology and dental therapies with 15 products and exploit other therapeutic areas having good growth potential, sending its shares up over 7%. The gynecology and dental segments boast a combined market size of about Rs20 billion in India and are growing 16% every year. The new division encompasses a sales force of over 100 representatives and would triple the count over the next two years. The launch helps company to strengthen its position in the rural as well as urban markets in India, by adding necessary investments made for growth in the business. India: Dow to sell polypropylene business to Braskem Braskem SA, Latin America’s largest petrochemicals maker, agreed to buy Dow Chemical’s polypropylene assets (PP) for a total enterprise value to Dow of US$340m, comprised of US$323m cash price plus other cash and contingency assumptions of US$17m. The deal includes Dow’s two PP manufacturing facilities in USA and two in Germany, with a total capacity of 1.05-mtpa. The German plants are located in Schkopau and Wesseling, while the US plants are at Freeport and Seadrift. Also included in the deal are inventory, business know-how, certain product and process technology and customer contracts and lists. India: Bayer rolls out novel technologies for gas phase phosgenation and ODC Bayer Material Science successfully tested its innovative gas phase phosgenation technology at a new plant being commissioned for the manufacture of TDI, at its integrated production site at Caojing in Shanghai, China. The process technology, which was implemented together with Bayer Technology Services, reduces solvent consumption around 80%, and energy consumption up to 60%, and enables a significant reduction in operating costs, and cuts investment costs for this type of large-scale facility by about 20%. Compared with conventional production facilities of similar size, CO2 emissions could be cut by around 60,000-tpa. India: Gevo setting up demo plant for processing biobased isobutanol US-based biofuels company, Gevo Inc, joined hands with a US petrochemical manufacturer South Hampton Resources Inc to build a hydrocarbon processing demonstration plant outside Houston, USA. Gevo uses proprietary yeast to ferment corn sugars into isobutanol, which Gevo said could be used to produce cleaner fuel and products like synthetic rubber. Gevo and South Hampton Resources announced plans to build a demonstration plant at South Hampton’s facility in Texas, which would process up to 10,000 gallons of isobutanol into renewable hydrocarbon materials including jet fuel for engine testing and isooctane for gasoline. The demonstration plant is expected to be completed later this year. India: Lanxess begins work on leather chemicals plant in China expands plastics plant Lanxess announced project investments totalling more than €40m in China. The company recently broke ground for a new leather chemicals plant in Changzhou, Jiangsu province, representing a €30m investment. The new plant would boast a capacity of 50,000-tpa and would come on stream in the first half of 2013. The plant would produce leather chemicals used for leather tanning, dyeing and finishing applications. Lanxess also started up the third production line of its high-tech plastics plant in Wuxi, Jiangsu province. The €10m investment increases total capacities at the plant to 60,000-tpa. India: GACL in expansion mode in South Guajrat The state venture Gujarat Alkalies & amp Chemicals Limited (GACL), commissioned its third phase 14,000 tonne per annum hydrogen peroxide expansion project at Dahej in South Guajrat. With this expansion, the total hydrogen peroxide production capacity of the company increased to 39,080 tonne A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 6 Pharma Professional August 2011 per annum. GACL dispatched first tanker of Hydrogen Peroxide from the newly expanded project on June 25. Meanwhile, the company is also in the process of setting up a project to manufacture 20,000 tonne per annum of sodium chlorate crystals. Rs14.35 billion. GACL awarded the job of engineering services, procurement assistance and supply of proprietary items for the project to UHDE India. Sodium chlorate is mainly used for bleaching in paper and pulp industries. Presently country's demand is met through imports. India: Aditya Birla Group completes Columbian Chemicals acquisition Aditya Birla Group completed the US$875m acquisition of Columbian Chemicals Company, an Atlantabased carbon black maker. The completion of the acquisition of Columbian Chemicals is indeed a milestone in the carbon black business. At one stroke it doubles the capacity, from 1 MT to 2 MT. Carbon black additives are used by tyre and other rubber manufacturers. Its products also service the ink and plastic segments. The acquisition, announced in January, helped the Aditya Birla Group to extend its geographical reach and in giving a foothold in North and South America, strengthening position in Europe and in emerging markets. India: Piramal Life's drug discovery with govt in phase-II The government’s department of biotechnology (DBT) and Piramal Life Sciences started the second phase of drug discovery partnership to find new drugs from 14,000 bio-active cultures, and Piramal Life Sciences. The bio-active cultures were discovered in a nationwide search for new drugs from bio-diverse habitats in collaboration with nine national institutes. The project achieved rapidity and 1,000 extracts out of the 14,000 would be evaluated within the next one-and-half years to obtain lead molecules. The project is jointly funded by the DBT and Primal Life Sciences. India: Fortis plans to set up 25 low-cost hospitals Fortis Healthcare plans to launch low cost hospitals in smaller towns under a new brand and set a target of 25 hospitals in three years. The new hospitals would provide healthcare services at affordable rates in semiurban India specifically tier-II & -III towns. The company’s spokeswoman refused to share investment details about the expansion. The company's share closed at Rs162.55, up 3.44%, at the Bombay Stock Exchange. The company would set up 10 new hospitals or ventures in the next 10 weeks to mark the company's completion of 10 years, besides offering 10 free surgeries at each hospital. Currently, the company boasts a network of 56 hospitals across the country, largely grown through acquisitions. Kerala: Sreedhareeyam group to open chain of 100 Ayurvedic clinics Sreedhareeyam group, which offers Ayurvedic eye care services, plans to open a chain of 100 clinics offering Ayurvedic general specialty treatments, under the brand name 'Soubhadra.' The group is planning to open 100 clinics across India over the next one year with Rs100m investment. The group planned to open 'Soubhadra' clinics at its main hospital at Koothattukulam in Ernakulam district and to its 12 other branches in Thiruvananthapuram, Ernakulam, Kozhikode, Delhi, Jaipur, Mumbai and Chennai. All the centres are full fledged with 'panchakarma' treatment facilities and rejuvenation programmes to boost immunity, besides specialised treatment for rheumatic disorders, skin diseases and respiratory ailments. India: KIMS sets up multi-speciality hospital in Kochi The Kerala Institute of Medical Sciences (KIMS), a leading healthcare provider in the state, set up a multispeciality hospital in Kochi as part of its efforts to provide quality medical facilities and to exploit the potential for medical tourism. The KIMS Hospital and Surgical Centre as it is called, encompass all facilities to cater to the healthcare needs of the international patients. Kochi already became a centre for medical tourism with several hospitals springing up in the last few years to meet the growing demand. The 125 bed hospital, following the footprints of its flagship hospital at Thiruvananthapuram, boasts immediate plans to obtain international and national quality accreditations. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 7 Pharma Professional August 2011 India: Max India to buy Warburg Pincus stake in health unit for Rs1.40 billion Max India decided to acquire private equity firm Warburg Pincus' 16.37% stake in its hospital chainMax Healthcare for Rs1.40 billion. Max India said in a statement to the stock exchanges that under the proposed transaction, the company is buying 47.60m shares of the hospital chain at Rs29.40 per share from Warburg Pincus. The acquisition is likely to conclude by December this year, increasing Max India's shareholding in the hospital subsidiary to 91.84%. The opportunity to consolidate shareholding in Max Healthcare came at the most opportune time when the business just turned profitable and is all set to double its bed strength. India: Life Technologies establishes IDC in India Life Technologies established an Indian regional distribution hub in Bangalore to strengthen its business in South Asian region. The new hub India Distribution Center (IDC) would ramp up the availability, timely delivery and quality of products to customers in the region. Life Technologies operates as Invitrogen Bioservices in India and commenced operations in the year 2005 from Bangalore. Life Technologies South Asia managing director opined that by locating the India Distribution Center in Bangalore, the company could bring technologies efficiently to their customers and partners in the region and help advance their science. India: Granules India, OmniChem to establish drug manufacturing plant Granules India signed a joint venture agreement with a Belgium-based pharma company Ajinomoto OmniChem to establish a bulk drugs and intermediaries manufacturing plant in Visakhapatnam, India with $20m investment. The joint venture, which is a 50-50 partnership deal, is expected to provide active pharmaceutical ingredients (API) to various other pharmaceutical firms. With this manufacturing plant, the companies are expected to offer drugs related to oncology, central nervous system (CNS) cardio vascular diseases (CVD) and would be able to handle 4-6 products at a time. India: Hyderabad firm launches tracking tool for pharma industry Goose, a city-based business re-engineering solutions provider, announced the launch of an indigenously developed product to help pharma industry meet the new regulatory packaging guideline, detect counterfeit drugs and protect their brand reputation. 'Procon Tracker' is a new addition to Goose's wide range of solutions adopted by several leading global pharma companies to increase business process efficiency. A Centre for Medicines in the Public Interest report estimated that globally counterfeit pharmaceutical commerce would grow to become 16% of the aggregate size of the legitimate industry, a 6% point rise from 2004. India: Dr Reddy's Labs receives approval to launch Fondaparinux Sodium injection Indian drug firm Dr Reddy's Laboratories received the final approval from theUSFDA to launch Fondaparinux Sodium injection, used for treating and preventing deep vein thrombosis (DVT). Dr Reddy's would manufacture Fondaparinux under a license using a patented process developed byAlchemia, a drug discovery and development company whose lead program was to develop a generic version of GSK's Arixtra. Alchemia's process for the synthesis of Fondaparinux is covered by a patent estate with two issued patents and two pending applications in the US. The Arixtra brand recorded US sales of approximately $340m for the 12 months ending May, 2011, according to IMS National Sales Perspectives. The Fondaparinux approval demonstrates the strong technical capabilities of the teams at Dr Reddy's and Alchemia. India: Venus Remedies launches pain killer injection in domestic market Venus Remedies launched its 'Achnil' injection, a pain killer, in the country. The novel formulation based on NDDS (Novel Drug Delivery System) technology would fill in the gap of long-standing demand for better pain management therapies, especially for the aged population. The product would not only reduce the number of pricks, but also drastically reduce the side effects associated with the use of non-steroidal, anti-inflammatory drugs (NSAIDs). According to the firm, the new product gives instant relief from acute pain and is effective for the next 24 hours against the conventional daily dose of three injections of diclofenac given every 8 hours. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 8 Pharma Professional August 2011 India: Bausch & Lomb enters Pharmaceutical market Lomb entered into a drug supply deal with Bangalore-based Micro Labs, marking its entry into the country's pharmaceuticals market. The two firms signed a memorandum of understanding (MoU), under which the American firm would leverage low-cost facilities of Micro Labs to manufacture its pharmaceutical products for the Indian market. Initially, the American firm would launch six eye drops made by its Indian partner. The company hired a sales team of 70 for the pharma operations, taking its total employees strength to 270 in the country. At present, the firm markets its vision care and surgical instruments. The domestic ophthalmic pharmaceuticals market is estimated double to US$300 million by 2015. India is among the fastest-growing markets in the world growing at over 15% annually. China: TPI to start test runs at JCM manufacturing plant Tianyin Pharmaceutical (TPI) is set to start test run at its 250-ton Jiangchuan Macrolide facility (JCM) for good manufacturing practice (GMP) certification process. The company would conduct the test runs by the end of this month to investigate whether the plant is maintaining GMP. Additionally, the company would also verify its performance, efficiency, reliability and safety of the Azithromycin API manufacturing at JCM. Following the successful completion of the test runs, the company would initiate the GMP certification process. Mergers & Acquisitions Americas USA: Verenium and Novus international agreement to develop animal nutrition enzymes Verenium Corporation, a leading industrial biotechnology company focused on the development and commercialization of high-performance enzymes, and Novus International, a leading manufacturer of animal and human nutrition and health products, announced a strategic collaboration to jointly develop and commercialize a suite of new enzyme products from Verenium's late-stage product pipeline in the animal nutrition and health area globally. The potential opportunity represents for the continued development of pipeline and for Verenium to become a more active participant in the animal health and nutrition marketplace with a suite of high-performance enzyme. USA: Enzo Biochem's clinical lab acquires to unique, diagnostic test for Cervical Cancer Enzo Biochem, as part of its continuing program to offer novel molecular tests, announced that its Enzo Clinical Labs subsidiary reached an agreement with IncellDx Inc. of Menlo Park, CA, for the rights to market a proprietary laboratory test. The test is based upon HPV OncoTect, an advanced molecular diagnostic technology for quantifying specific biomarkers that are associated with an increased risk of progression to cervical cancer and would further expand Enzo's approach to provide comprehensive clinical information to physicians for managing diseases associated with women's health. Upon receiving the appropriate approvals, Enzo would become the first New York licensed reference laboratory to offer the test. USA: Astellas Signs License Deals with Vical Astellas Pharma signed exclusive license agreements to develop and commercialize Vical's TransVax, a bivalent DNA vaccine designed to control cytomegalovirus reactivation in transplant recipients. As per the deals, Vical would provide assistance to Astellas with TransVax-related manufacturing, regulatory and certain development activities, for which Astellas will reimburse all of Vical's future costs, including personnel and external expenses. Vical holds an option to co-promote TransVax in the US. It will receive near-term payments of US$35m, including US$25m upon the effective date and US$10m upon finalization of the Phase 3 trial design. Vical potentially would receive up to US$130m in total upfront and milestone payments through commercial launch and double-digit royalties on net sales. USA: Watson Pharma to Commercialize Anturol in US and Canada Watson Pharmaceuticals signed an exclusive licensing agreement to commercialize Antares Pharma's topical oxybutynin gel product Anturol in the US and Canada. Oxybutynin product is a clear, odorless topical gel that demonstrated to be an effective and safe treatment for overactive bladder (OAB), a A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 9 Pharma Professional August 2011 condition that affects more than 30 million Americans. As per the deal, Watson would make milestone payments based on the achievement of regulatory approval and certain sales levels, and would also be responsible for certain manufacturing start-up activities. Antares would receive escalating royalties based on product sales after launching the product in the US and Canada. Additional details on the agreement are not been disclosed. USA: HUYA Bioscience and Liaoning Form Partnership HUYA Bioscience International formed a strategic partnership with the Liaoning (Benxi) Biopharmaceutical Industry Base, which is situated in between Benxi and the Liaoning provincial capital, Shenyang. As per the deal, HUYA would provide assistance in evaluating research and development projects conducted by pharmaceutical enterprises residing in Liaoning (Benxi) Bio-pharmaceutical Industry Base. HUYA would also be able to globalize select programs from Liaoning (Benxi) Biopharmaceutical Industry Base through its co-development model and worldwide pharmaceutical partners.HUYA's knowledge and capacity in international drug development, Liaoning (Benxi) Biopharmaceutical Industry Base hopes to solidify its position as a leading medical and pharmaceutical base in China. USA: BMS Signs Immunity-From-Suit Agreement with Matrix Bristol-Myers Squibb Company (BMS) signed a new immunity-from-suit agreement with Matrix Laboratories to expand access to Reyataz (atazanavir sulfate) in sub-Saharan Africa and India. As per the deal, Matrix Laboratories would secure World Health Organization (WHO) prequalification for all products covered by the deal, including pediatric formulations of didanosine and, in the future, atazanavir powder formulation for pediatric use when BMS' product is available. The deal allows the generic company to manufacture and sell atazanavir, as well as stavudine and didanosine, in sub-Saharan Africa and India. BMS signed 14 agreements for its HIV medicines. The present deal is 15th agreement, and the fourth for atazanavir. India: BASF & CSM explore bio-based succinic acid joint venture BASF SE and Purac, a subsidiary of CSM NV, announced the start of negotiations to form a joint venture for the production of bio-based succinic acid. The joint venture hopes to become the first commercial producer in the market with a 25,000-tpa fermentation production plant at the Purac site near Barcelona, Spain, with the intention to start up by 2013 at the latest. In addition, there are plans afoot for a world-scale plant with a capacity of 50,000-tpa. The complementary strengths in fermentation and downstream processing led to the development of a sustainable and highly efficient manufacturing process based on proprietary micro-organisms. India: Dow & Saudi Aramco to set up mega chemicals complex Dow Chemical and the Saudi Arabian Oil Company announced the formation of a joint venture (JV) to build and operate a US$20 billion world-scale, fully integrated chemicals complex in Jubail Industrial City, Saudi Arabia. The joint venture, Sadara Chemical Company, would encompass capacity to make more than 3-mtpa of chemicals a year. Comprised of 26 manufacturing units building on Saudi Aramco’s project management and execution expertise, and utilising many of Dow’s industry leading technologies, the complex would be one of the world’s largest integrated chemical facilities, and the largest ever built in one single phase. India: DuPont acquires silicon inks firm DuPont acquired US-based Innovalight Inc, a solar technology company that graduated out of the US Department of Energy’s photovoltaic Incubator programme and has since signed major agreements with overseas solar manufacturers. Innovalight invented a liquid form of silicon ink and an ink-jet approach to ‘printing’ solar cells. The innovation dramatically improves the performance of solar cells and could boost profits for manufacturers by 20%. Innovalight’s silicon ink is a so-called ‘selective emitter’ technology, which allows solar cells to capture a broader spectrum of sunlight for conversion into electricity. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 10 Pharma Professional August 2011 India: Opto Circuits enters Japanese market through Omron Healthcare Opto Circuit entered into a distribution agreement with patient monitoring device maker Omron Healthcare. Through the deal, the companies would provide automated external defibrillator (AED) that is used for heart patients and the first sales are expected in August. Kyoto-based Omron produces blood monitors and would distribute the AEDs through its home-use and medical healthcare devices division, a press statement stated. Cardiac Science develops, manufactures, and markets AEDs, ECGs, cardiac stress treadmills amongst others. Opto Circuits transferred the investments of three US subsidiaries- Cardiac Science Corporation, Criticatre Systems and Unetixs Vascular into Opto Cardiac Care, a wholly owned subsidiary of Opto Circuits. India: Par agrees to acquire Edict Pharmaceutical Hikma enters partnership with Unimark Par Pharmaceutical Companies entered into a definitive agreement to acquire privately-held Edict Pharmaceuticals, a developer and manufacturer of generic pharmaceuticals, for up to US$37.6m in cash and Par’s repayment of certain additional pre-close indebtedness. The transaction is expected to be accretive in 2013. Edict is a Chennai-based developer and manufacturer of solid oral dosage generic pharmaceuticals with a highly-skilled research and development team and strong product pipeline focused on niche first-to-file, first-to-market formulations. Edict currently encompasses seven ANDAs filed with the FDA and one ANDA filed in the name of a development partner, with an additional 14 products in development. India: Elite Pharma, ThePharmaNetwork sign manufacturing deal Elite Pharmaceuticals, a developer of oral sustained and controlled release products, entered into a manufacturing and supply pact with ThePharmaNetwork and its wholly owned subsidiary Ascend Laboratories (collectively TPN). Elite operates a GMP and DEA registered facility in Northvale, NJ for research, development and manufacturing. Under the agreement, Elite would manufacture and package TPN's Methadone Hydrochloride, 10mg tablets. Elite chairman said that TPN with the launch and commercialization of their Methadone product and in light of the recent action by the FDA with the Lodrane family of products, the agreement would help Elite buffer the impact by providing a new revenue stream. India: Ranbaxy Signs In-Licensing Deal with Gilead Sciences Ranbaxy Laboratories, a member of the Daiichi Sankyo Group, signed an in-licensing agreement with Gilead Sciences for three new HIV/AIDS drugs, which are currently in late-stage clinical development. Under the terms of the arrangement, Ranbaxy would enjoy the rights to manufacture and market generic equivalents of Elvitegravir, an investigational integrase inhibitor, Cobicistat, an investigational antiretroviral boosting agent and Quad, which combines four Gilead HIV medicines in a once-daily, single-tablet regimen. After gaining necessary regulatory approvals, Ranbaxy would be entitled to produce and sell generic versions of these drugs, under license, in India and other developing nations. Investments UK London: Aureos invests US$10m in Indian healthcare group BSR Super Speciality Hospitals Aureos Capital, private equity fund management with a focus on emerging markets, invested US$10m in a leading Indian healthcare group BSR Super Speciality Hospitals. The Chief Executive Officer of Aureos Capital told media last night that the group completed US$10m investment in Central India-based hospital chain. BSR's strategic alignment with Aureos would pave the way for continued expansion in its network of hospitals and diagnostic centres in wider geographies. Vettivetpillai added the hospital aims to start imaging diagnostic centres and several new hospitals in the region, including a 150-bed multispeciality hospital in Nagpur and a hospital in Rajnandgaon. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 11 Pharma Professional August 2011 Asia-Pacific India: Life Technologies invests US$3m in distribution hub in Bangalore Biotechnology firm Life Technologies invested around US$3m to open a distribution hub in Bangalore, which they expect propeled their business in India by 40% this year. South Asia is one of the fastest growing regions in the world. Opening the India Distribution Center is a clear demonstration of Life Technologies' commitment to the scientific community, who increasingly conduct high-level research and development in South Asia. According to the Managing Director, Life Technologies South Asia, the center would distribute products across the country cutting the time taken for delivery from 45 days to two days, which would also increase the cost efficiency for the company. India: Orchid Chemicals to invest Rs2 billion on therapeutic products Orchid Chemicals and Pharmaceuticals plans to invest Rs2 billion this year on niche therapeutic products and also plans to set up a new manufacturing facility for these therapeutic formulations, which include dietary supplements and herbal medicines, diabetes products, blood-related products, and those used in cellular and tissue therapies and identified three niche products, which would give a diversified competitive positioning in the market as these would be difficult to manufacture to raise Rs10 billion. The company, which pledged around 70% of promoter holding, hopes to reduce it by half in a few months. India: Sipchem setting new polymer R&D centre to invest Rs150m in Saudi Arabia The Saudi International Petrochemical Company (Sipchem) is investing around 150m (US$40m) to construct its corporate Research and Product & Application Center at the Dhahran Techno Valley (DTV) of King Fahd University of Petroleum and Minerals (KFUPM) in Saudi Arabia. Sipchem already started construction of the centre, which is designed with the objective of developing usage of polymer products and downstream industries in Saudi Arabia. It is likely to begin operations in the middle of 2012. Around 50 scientists, researchers and technicians with experience in polymer engineering and technology would be working at the centre. India: IPL to invest about Rs3 billion on Sugar Plant in Bihar Indian Potash Ltd would invest about Rs3 billion to set up a sugar plant and distillery in Bihar. At present, IPL operates five sugar plants in Uttar Pradesh (UP) with a total crushing capacity of 12,000 tonnes of cane per day. IPL would also establish a sugar plant in Muzaffarpur district, in Bihar, along with a distillery to produce Indian-Made Foreign Liquor (IMFL), with an investment of Rs2.80 billion. The company would soon start construction work on the sugar and distillery plant in Bihar. The sugar plant would boast a capacity of 3,500 tonnes of cane crushed per day, while the distillery would produce 45,000 litres per day. During the last fiscal, IPL established four sugar plants in UP, taking its total plants in the state to five. India: Apollo plans investment Rs1 billion on Health Park in Andhra Apollo Hospitals is understood to be planning to invest around Rs1 billion to set up a mega health park at Chittoor district in Andhra Pradesh. According to sources, the project, to be spread over 86 acre of land, would be completed in three years. The health park would include a 200-bed multi specialty hospital and a nursing college. The company is likely to start preliminary study of the location for setting up the park. The group is also planning to set up three medical colleges at Chennai, Hyderabad and Madurai as a part of its expansion plans in medical education venture and expects the first of the three colleges to start functioning within the next two years. The healthcare chain also operates 1,200 pharmacies and 54 hospitals with a capacity of over 8,500 beds besides over 100 diagnostic clinics across the country. India: Narayana Murthy's PE Fund invests in Wellspring Healthcare NR Narayana Murthy's venture capital firm Catamaran, the Anil Ambani Group’s Reliance Venture Asset Management and some foreign investors invested in Mumbai-based healthcare services provider Wellspring Healthcare. Catamaran, Murthy's US$129m venture capital fund, Reliance Venture Asset Management, US-based Blue Cross BlueShield Venture Partners and few angel investors invested 205m in Wellspring's first round funding. Mumbai-based Wellspring would use the money to create a chain of clinics under the brand name of 'Healthspring Community Medical centres' in Mumbai and roll it out nationally later. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 12 Pharma Professional August 2011 India: Rakshit Phytopharma to set up Rs 30mn medicinal plant project in Bengal Phytopharma announced its plans for setting up an ayurvedic herbs and medicinal plants unit in West Bengal at an investment of Rs30m. The company would be involved in cultivation, processing and extraction of these herbs and medicinal plants and would supply the extracts to pharmaceutical and FMCG industries in India and abroad. According to industry estimates, the market size of ayurveda is estimated to be around Rs80bn and is growing at a rate of 10% -15% year on year. Around Rs 15bn worth ayurvedic medicine are exported every year. Of this, 60% is crude herbs, 30% are finished products shipped abroad for direct sales and 10% are partially prepared products. Others Americas USA: USDA announces availability of compliance guide to help reduce foodborne illness The US Department of Agriculture´s Food Safety and Inspection Service (FSIS) is providing a set of draft guidelines to help small and very small meat and poultry manufacturers reduce harmful bacteria in readyto-eat foods. This guide sets out standard regulatory procedures and would aid establishments to understand how best to operate to ensure a safer quality product. The prevention of food borne illness is top priority, in the Administrator of FSIS. These guidelines spell out FSIS´ recommended best practices when comes to producing food items that consumer usually do not cook before eating. Its goal is to help industry apply some of the recent lessons learned so they could prevent future problems, resulting in safer ready-to-eat food for consumers. Asia-Pacific India: Revenues of Indian biotech sector surge to US$4 billion in 2010-11 The biotech industry contributed Rs172.49 billion, while the life science education market made up the remaining Rs11.50 billion, according to the 9th annual BioSpectrum-Association of Biotechnology Led Enterprises (ABLE) survey. The biotech industry, without the life sciences education component, recorded revenue growth of 21.5% in 2009-10 with revenues of Rs141.99 billion. The top 10 South-based companies, led by Biocon, accounted for US$1 billion in revenues. The contribution of the 'BioPharma', 'BioServices', 'BioAgri', 'Bioindustrials' and 'Bioinformatics' verticals was Rs106.45 billion, respectively. The BioPharma vertical contributed almost two-fifths of industry revenues, followed by BioServices with 18.82% and BioAgri with a 14.38% contribution. India: Dow plans new reverse osmosis membranes plant in Saudi Arabia Dow Chemical is planning to invest in a facility for manufacturing its ‘Filmtec’ reverse osmosis elements in Saudi Arabia. The proposed facility delivers local supply security of cutting-edge technologies for water desalination and water re-use for potable, non-potable and industrial water serving Saudi Arabia, the surrounding Middle East and North Africa region and emerging markets worldwide. Dow’s ‘Filmtec’ membranes are used in some of the most water-challenged areas of the world. India: JB Chemicals completes sale of Russian, CIS OTC biz to J&J JB Chemicals & Pharmaceuticals Ltd completed Rs9.39 billion deal to sell its over-the-counter business in Russia and CIS countries to Johnson & Johnson arm Cilag GmbH International. JBCPL said in a filing to the Bombay Stock Exchange (BSE) that the company received nearly Rs7.38 billion and an agreed portion of consideration in an escrow account. The Russia CIS (Commonwealth of Independent States) OTC business along with OTC brands now vests in Cilag. The company now supply the acquired products to Cilag for these markets. The Russian subsidiary of the company also completed the sale of its OTC business to Johnson and Johnson LLC for US$35m. India: Fineotex incorporates wholly-owned subsidiary in Malaysia Fineotex Chemicals incorporated a wholly-owned subsidiary in Malaysia to carry on its business in that region. The company is also in advance stages of negotiations with foreign parties for investing in business in and around Malaysia. The company incorporated a wholly-owned subsidiary in Malaysia to carry on the business in that region. It is in advance stages of negotiations with foreign parties for A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 13 Pharma Professional August 2011 investing in business in and around Malaysia in a filing to the Bombay Stock Exchange (BSE). Fineotex manufactures speciality chemicals among others for textile, garment, construction, leather, water treatment, paint industries. India: Govt not to pay higher subsidy on old stock of P&K fertilisers In a major blow to the fertiliser industry, the government decided not to pay a higher subsidy to companies on old stock of finished phosphatic and potassic (P&K) fertilisers and raw materials this year. While the development would help the government reduce its fertiliser subsidy bill by Rs5 billion, the decision is expected to prevent private players from reaping windfall gains and also from entering into long-term contracts for imports. It is decided to make payment to the manufacturers/importers on the carried over quantity of P&K fertiliser, including SSP and various raw materials for P&K, as on March 31, 2011, as per the NBS rates that prevailed in January-March, 2011. India: India, China to work together for improving health services India and China decided to work together in improving health care services and deepening of bilateral cooperation in the health sector. Health Ministers of the two nations, who met in Dalian in China on the sidelines of the 18th Executive Committee meeting of Partners in Population Development (PPD), also decided to take forward the agenda of population development and boost south-south cooperation. PPD, an inter-governmental initiative for expanding and improving South-to-South collaboration in reproductive health, population and development, also adopted its new governance Charter and drafted its strategic business plan for 2012-14. India: Opto Circuits gets approval to market cardiac devices in Japan Medical equipment maker Opto Circuits received an approval to market its automated external defibrillators in Japan. The approval is granted to company's subsidiary 'Cardiac Science Corporation' by the Ministry of Health, Labour, and Welfare to market Powerheart G3 Automated External Defibrillators (AED) in Japan, Opto Circuits said in a filing to the Bombay Stock Exchange (BSE). External defibrillators are medical devices that diagnose life-threatening abnormal heart rhythms, or cardiac arrhythmia, and deliver electrical energy to the heart to restore its normal rhythm. India: Vasan Healthcare may sell 15% to GIC for US$100 million Vasan Healthcare is in advanced talks to sell up to 15% stake to Singapore sovereign wealth fund GIC for around US$75-100m. GIC is the frontrunner among 4-5 investors, the Chennai-based company is negotiating with, although the Singapore fund declined to comment. Vasan, which runs the country's largest chain of eye hospitals expected to close the deal in eight weeks. The company, which was born as a pharmacy and now counts venture capital firms Sequoia Capital and Westbridge Capital among its investors, hopes to use the funds from the latest round of fund raising to fund its expansion plans ahead of a proposed public flotation next year. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 14 Pharma Professional August 2011 Product Focus – Losartan Introduction Losartan is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure hypertension. Losartan was the first angiotensin II receptor to be marketed. Losartan is currently marketed by Merck & Co. under the trade name Cozaar. Losartan is indicated for the treatment of hypertension. Losartan may also delay progression of diabetic nephropathy. Losartan is also indicated for the reduction of renal disease progression in patients with type 2 diabetes, hypertension and microalbuminuria or proteinuria. Losartan is significantly superior to atenolol in the primary prevention of adverse cardiovascular events (myocardial infarction or stroke), with a significant reduction in cardiovascular morbidity and mortality for a comparable reduction in blood. Mechanism of Losartan Losartan is a selective, competitive Angiotensin II Drug Details receptor type 1 receptor antagonist, reducing the end Mol Mass 422-91 organ responses to angiotensin II. Losartan Bioavailability 25-35% administration results in a decrease in total Metabolism Hepatic (CYP2C9, CYP3A4 peripheral resistance and cardiac venous return Excretion Renal-13-25%,biliary-5-60% (preload). All of the physiological effects of Perception only angiotensin II, including stimulation of release of Legal Status SMILES Molecules & Pubchem aldosterone are antagonised in the presence of 1.5 -2 hours losartan. Reduction in blood pressure occurs Half Life independently of the status of the renin-angiotensin system. As a result of losartan dosing, plasma renin activity increases due to removal of the angiotensin II feedback. Research of Losartan Losartan is founded to down regulate the expression of transforming growth factor beta (TGF-β) types I and II receptors in the kidney of diabetic rats, which may partially account for its nephroprotective effects. Effects on TGF-β expression could also account for potential efficacy in Marfan syndrome and Duchenne muscular dystrophy – losartan is shown to prevent aortic aneurysm and certain pulmonary complications in a mouse model of the disease. Losartan is also being studied for use in the treatment the 20% of breast cancer tumors positive for AGTR1. The University Of Michigan Comprehensive Cancer Center announced the result of an animal study found losartan to block - reverse neoplastic changes caused by this gene. Pharmacokinetics World Manufacturers & Suppliers of Losartan Losartan is well absorbed following oral Taizhou Zhongrong Chemical Co. Ltd administration and undergoes significant first Zhejiang Shaxing Pharma Ltd pass metabolism to produce 5-carboxylic acid Brookes Pharmaceutical Laboratories metabolite, designated as EXP3174. Shanghai Jiangbei Pharmaceutical Co Ltd Metabolite is long-acting (6 to 8 hr), and noncompetitive antagonist at the AT1 receptor and contributes to the pharmacological effects of Losartan. Metabolite is 10-40 times more potent in blocking AT1 receptors than the original Losartan. Its bioavailability is about 32%. Dose and Cost: Losartan is available in 25 and 50mg unscored tablets, which could be halved. The average daily cost for 12.5 to 100 mg daily is US$0.55-2.20. The daily cost range for the 9 ACE inhibitors available in B.C. is US$0.45-2.10. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 15 Pharma Professional Adverse effects Other than a low incidence of dizziness, losartan was not associated with any adverse effects at a significantly higher rate than placebo. Dry cough does not appear to be a problem with angiotensin II antagonists, presumably because they do not show any effects on bradykinin metabolism. Indian Scenario August 2011 Indian manufacturers & suppliers of Losartan Dev Bhoomi Pharmaceuticals Innova Cap Tab Servocare Life Sciences Allied Chemicals & Pharma Pvt Ltd Marksans Pharma Limited M. N. Pharma Ranbaxy Laboratories made the day-one-launch of generic, Losartan K 50mg and 100mg tablet in Malaysia. The market size of Losartan K Tablets in Malaysia is US$7.29m. Ranbaxy Laboratories Limited is an integrated, research based, international pharmaceutical company, producing a wide range of quality, affordable generic medicines, which are widely trusted by healthcare professionals and patients across geographies. Ranbaxy's continued focus on R&D resulted in several approvals in developed markets and significant progress in New Drug Discovery Research. Outlook The outlook for Losartan remains robust, driven by high patient populations and a widespread focus on preventative treatment. However, low growth rates in established indications would prevail due to the growing availability of effective generic medicines and an overall scarcity of innovative new drug launches. Major Pharma companies are now primarily focusing their efforts upon compliance and protection against the generic threats posed by line extensions and combination treatments. Changes in the competitive positions of leading companies became inevitable as new revenue sources continue to decline and established portfolios under perform. With coverage of over 90% of the total market for cardiovascular products, this report profiles the underlying trends and factors driving the market and identifies the most promising areas of potential growth. A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 16 Pharma Professional August 2011 Stock Scan 110 Relative Market Cap Performance 100 BSE Sensex Piramal C ipla 07/07/11 08/07/11 11/07/11 12/07/11 13/07/11 14/07/11 15/07/11 08/07/11 11/07/11 12/07/11 13/07/11 14/07/11 15/07/11 06/07/11 05/07/11 04/07/11 01/07/11 30/06/11 29/06/11 28/06/11 27/06/11 07/07/11 110 24/06/11 23/06/11 22/06/11 21/06/11 20/06/11 17/06/11 16/06/11 90 Relative Market Cap Performance BSE Sensex SHASUN AUROBINDO 100 06/07/11 05/07/11 04/07/11 01/07/11 30/06/11 29/06/11 28/06/11 27/06/11 24/06/11 23/06/11 22/06/11 21/06/11 20/06/11 17/06/11 16/06/11 90 Source: BSE India; Cygnus Research Index BSE (Points) CIPLA (Rs) PIRAMAL (Rs) SHASUN (Rs) AUROBINDO (Rs) Index BSE (Points) CIPLA (Rs) PIRAMAL (Rs) SHASUN (Rs) AUROBINDO (Rs) 1st Week (16-23 Jun 2011) Opening Closing Var(%) 17,985.88 17,727.49 -1.44 329.65 315.80 -4.20 369.35 369.55 0.05 76.35 71.65 -6.16 175.20 167.20 -4.57 2nd Week (24th Jun-30th Jun 2011) Opening Closing Var(%) 18,240.68 18,845.87 3.32 326.35 330.35 1.23 373.80 396.70 6.13 73.15 76.30 4.31 170.40 172.50 1.23 3rd Week (1st Jul-6th Jul 2011) Opening Closing Var(%) 18,762.80 19,078.30 1.68 326.25 334.60 2.56 393.95 394.85 0.23 77.05 75.70 -1.75 170.60 171.80 0.70 4th Week (7-15th Jul 2011) Opening Closing Var(%) 18,858.04 18,561.92 -1.57 332.50 324.00 -2.56 392.50 396.05 -2.56 75.65 75.75 0.13 169.95 173.85 2.29 A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 17 Pharma Professional August 2011 Upcoming Events 1. Event Date Venue Highlights 2. Contact Details Event Date Venue Highlights 3. Contact Details Event Date Venue Highlights Contact Details 4. Event Date Venue Highlights Contact Details 5. Event Date Venue Highlights Contact Details CPhi South America Aug 24-26, 2011 Transamerica Expo Center Sao Paulo, Brazil It will undoubtedly bring a wealth of opportunities to the pharmaceutical industry. With a rapidly emerging market second only to China and a growth rate exceeding that of the global average, South America continues to promote an attractive business arena to many Western firms. CMP Information Industrieweg 54, P.O. Box 200, 3600 AE, Maarsen, The Netherlands; Tel: +(31)-(346)-559444; Fax: +(31)-(346)-573811 Pack Tech Asia Aug 27-29, 2011 Milan Mela Ground Kolkata, India It is an International Exhibition on processing, filling and packaging technology, which would showcase the entire spectrum of products, latest Trend, Technology equipments and services in food processing, pharmaceuticals, beverages, confectionery, bakery, Ayurveda and Herbal products, Cosmetics, Agro Products and many more. Kesari Media & Events Pvt. Ltd, Scf 172-A, First Floor, Grain Market Sector-26, Chandigarh, India; Tel: +(91)-(172)-2790007 World Congress of Pharmacy and Pharmaceutical Sciences 2011 Sep 03-08, 2011 (HICC), Hyderabad, India It will be a showcase of international healthcare providers and the industry, displaying their products & services for delegates, to stay in touch with the latest trends and developments in the pharmaceutical world. It will also be an ideal platform for Indian entrepreneurs to demonstrate their abilities in meeting the requirements in terms of global pharmaceutical needs. Hyderabad International Convention Centre, Novotel and HICC Complex, (Near Hitec City) P o Bag 1101 , Cyberabad Post Office, Hyderabad - 5000081 Tel: + 91 40 6616 3000; Fax : + 91 40 6613 4322 China International Emergency Medical Expo Sep 02-04, 2011 Chengdu New International Convention & Exposition Center Chengdu, China It will be attended by Doctors (surgery and hospital), Hospital administration managers and staff, Hospital technical staff, and Biologists from varied parts of the world. Reed Sinopharm Exhibitions Co. Limited ( Reed Sinopharm), 15th Floor Tower B, Ping An International Finance Center, No.1-3, Xinyuan South Road, Chaoyang Dist, Beijing, China; Tel: +(86)-(10)-84556677; Fax: +(86)-(10)-62033210 Bio Pharm America Sep 07-09, 2011 Boston Marriott Burlington Boston, United States Of America It is the sole international exhibition in Massachusetts that focuses on biomedicine and medical industry. The exhibition offers great opportunity to meet all the professionals under one roof. It will showcase latest innovation products and equipments for related industry. E.B.D. Group, Inc., 2032 Corte del Nogal, Suite, Carlsbad, USA Tel: +(1)-(760)-9300500; Fax: +(1)-(760)-9300520 A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 18 Pharma Professional 6. Event Date Venue Highlights 7. 8. 9. Contact Details Event Date Venue Highlights Contact Details Event Date Venue Highlights Contact Details Event Date Venue Highlights Contact Details 10. Event Date Venue Highlights Contact Details August 2011 Pharma eMarketing Congress 2011 13-14 September 2011 Lisbon, Portugal The Pharma eMarketing Congress reflects the dramatic marketing changes in the Pharma industry that were prompted by technology changes in the past decade. It helps to learn about Pharmaceutical eMarketing and brainstorm the best practices in this booming Pharma sector. PMR,ul. Dekerta 24, 30-703, Kraków, Poland; Tel: +48 12 618 90 00 Fax: +48 12 618 90 08; E-mail: info@pmrcorporate.com ChemInnovations Sep 13-15, 2011 George R. Brown Convention Center Houston, United States Of America It is titled as the biggest event for Chemicals & Dyes. It is the international event, which gives a view of chemical Apparatus and plant installation, Chemical process tech, Maintenance and QC, Environmental Protection, and Petrochemistry during 3 days of event. The TradeFair Group, Inc., 11000 Richmond, Suite, Houston, USA Tel:+(1)-(832)-2421969; Fax:+(1)-(832)-2421971 Baku International Healthcare Exhibition Sep 13-15, 2011 Baku Expo Center Baku, Azerbaijan It will bring together all the key players under one roof, providing exhibitors with a compelling networking opportunity to precisely target relevant budget-holders in the shortest time possible and at an affordable cost. ITECA Caspian, 63, Ac. Hasan Aliyev Str., 5th Floor, Baku, Azerbaijan Tel:+(99)-(41)-4474774; Fax:+(99)-(41)-4478998 World Dental Show Sep 16-18, 2011 MMRDA Exhibition Center Mumbai, Maharashtra, India It is the flagship exhibition event hosted by the Indian Dental Association. Bench marked to the highest standard of international facilitation in regards to the oral health care industry, it is aimed to be the annual exhibition event of IDA, year after year. The ever growing demand for the latest dental procedures from people across the country and the status of the country as one of the best and most affordable oral healthcare destinations add flavour to the Show. Indian Dental Association (IDA), Bombay Mutual Terrace, 2nd Floor, 534, Sandhurst Bridge, Opera House, Mumbai - 400 007, India; Tel: +(91)-(22)43434545 Pharmac India Sep 17-19, 2011 Gujarat University Exhibition Hall It is recognized as a focused exhibition for Pharma and Health care industry. It is 3 days exhibition, which aims towards highlighting of varied related medical products. The exhibition would prove to be a large hub of reputed professionals from pharmaceutical formulation, herbal products, veterinary drug, medical and disposal, pharmaceutical machinery and many other sectors. Orbitz Exhibitions Private Limited, 202, Navyug Industrial Estate, T. J. Road, Sewree, Mumbai, India; Tel: +(91)-(22)-24102801; Fax: +(91)-(22)-24102805 A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 19 Pharma Professional 11. Event Date Venue Highlights Contact Details 12. 13. Event Date Venue Highlights Contact Details Event Date Venue Highlights Contact Details 14. Event Date Venue Highlights Contact Details 15. Event Date Venue Highlights Contact Details August 2011 Pharma supply chain forum Sep21, 2011 Taj kands End Mumbai It will bring together industry’s best SCM practitioners from Indian Pharma and biotechnology companies under one roof. The conference would focus exclusively on Indian Pharma industry. It will deliver keynote panel discussions, presentations and case studies by industry people. It will also provide opportunities to interact with key decision makers from the industry on a face to face and learn understand and implement the new tools and technologies in Pharma SCM. KamiKaze B2B Media, 216, 2nd floor, Manish Shopping Centre, J. P. Road, Andheri (West), Mumbai - 400053, India. Tel: 022 26395102, Email. harish@elscconcalve.com Chemical Industry Sep 26 – 01, Oct, 2011 International Fair Plovdiv, Bulgaria The first edition of the exhibition was launched in 2004 based on the existing Specialized Salon of Chemical Industry and in compliance with the modern trends and developments in the exhibition industry. The main aim is to improve the effectiveness of participation. International Fair Plovdiv, 37, Tzar Boris III - Obedinitel, Plovdiv, Bulgaria Tel:+(359)-(32)-902000; Fax:+(359)-(32)-902432 Hospital Tech Oct 08-09, 2011 Gujarat University Exhibition Hall, Ahmedabad, Gujarat, India It is the biggest trade fair in India for healthcare sector. The trade fair provides an ideal platform for companies from all over India and beyond to showcase exhibits and the latest technologies as well as to interact directly with potential buyers and sellers, collaborators and information seekers. Confederation of Indian Industry, Ahmedabad, 203-204, Sears Tower, Gulbai Tekra Near Panchwati, Ahmedabad, India Tel:+(91)-(79)-65215956; Fax:+(91)-(79)-26462878 India Chem Gujarat Oct 13-15, 2011 Gujarat University Exhibition Hall Ahmedabad, Gujarat, India It will showcase potential of the chemical and allied industry. The exhibition offers a platform for discussing varied areas of the sector along with the environmental concerns. The event is being organized by Federation of Indian Chambers of Commerce and Industry. Federation of Indian Chambers of Commerce & Industry, Federation House, 1, Tansen Marg, New Delhi - 110 001, India. Tel: +(91)-(11)-23738760; Fax: +(91)-(11)-23320714 P-Mec India Nov 30–02, Dec 2011 Bombay Exhibition Centre(BEC) Mumbai, India It is a Pharmaceutical-Machinery and Equipment Convention. The exhibition is primarly meant for the supplier of quality equipment and machinery for pharmaceutical manufacturing industry. It will provide the opportunity to showcase their latest accomplishments in pharmaceutical machinery and equipment. It will be held alongside the ICSE and CPhI events, offering complete coverage of all developments in the pharmaceutical word. UBM India Pvt. Ltd., Sagar Tech Plaza A, 615-617 6th Floor, Andheri Kurla Road Saki Naka Junction, Andheri East, Mumbai, India Tel: +(91)-(22)-66122648; Fax: +(91)-(22)-66122626 A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 20 Pharma Professional 16. Event Date Venue Highlights Contact Details 17. Event Date Venue Highlights 18. Contact Details Event Date Venue Highlights Contact Details 19. Event Date Venue Highlights Contact Details August 2011 Industrial Green Chemistry World Dec 04-06, 2011 TBA Mumbai, India It is a global platform for the Chemical Industry to explore, engage and exchange emerging trends and innovations implemented in the field of Industrial Green Chemistry and Engineering. It is an initiative by the Green ChemisTree Foundation, a philanthropic expression founded by Newreka Green Synth Technologies Pvt. Ltd for promoting, Green Chemistry and Green Engineering (GC&E) practices amongst diverse sections of societies, such as Industry, Govt. bodies, Research Institutes, Academia, Students, and others. Newreka Green Synth Technologies Private Limited, 405, Mastermind IV, Royal Palms, Aarey Colony Goregaon (East), Mumbai, India Tel: +(91)-(22)-28791835; Fax: +(91)-(22)-28794790 The FT Global Pharmaceutical and Biotechnology Conference 2011 Dec 5-6, 2011 Marriott Grosvenor Square, London. Governments continue in their efforts to reduce healthcare costs, by doing so they are gradually reducing the price they are willing to pay for pharmaceutical products. The resulting fall in revenues is forcing a growing number of life science companies to reassess their commitment to R&D, and to move an increasing proportion of their research efforts to emerging markets. Michael Lundby; Tel: +44 (0)20 7873 3837 Email: mike.lundby@ft.com; www.eiseverywhere.com 9th BioPharma India Convention 2011 Dec 6-8,2011 Mumbai, India It is India’s only event where biopharma industry stakeholders across the entire value chain gather. From partnering to drug discovery, manufacturing and clinical trial, BioPharma India Convention brings the latest developments in India that allow being on top of the game. Terrapinn Pte Ltd; 1 Harbourfront Place; #18-01 Harbourfront Tower 1; Singapore 098633; Tel: +65 6222 8550; Fax: +65 6226 3264 website: enquiry.sg@terrapinn.com Pharma Technology Show Dec 07-10, 2011 NSIC Exhibition Complex New Delhi, India Its aim is at bringing together world renowned companies as well as newly launched companies on one platform. It is an invitation to all those who want to seize this opportunity and to further galvanizing their position to take share of this lucrative market. Print Packaging.Com Private Limited, F 101, Tower No. 7, First Floor, International Infotech Park, Vashi Railway Station, Vashi, Navi Mumbai, India Tel: +(91)-(22)-27812619 A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 21 Pharma Professional 20. Event Date Venue Highlights Contact Details 21. Event Date Venue Highlights Contact Details August 2011 India Lab Expo Dec 08-10, 2011 Pragati Maidan New Delhi, Delhi, India It is the India's unique and most comprehensive exhibition on Laboratory, Scientific, Biotechnology, Analytical, Educational, Material Testing, Diagnostics and related products for major Indian and International manufacturers, exporters, importers and key regional suppliers. The international trade exhibition focuses on latest laboratory technologies and accessories. It is an ideal platform as a meeting ground for scientists, researchers, and institutional heads and industry captains, to look at viable laboratory solutions. S. D. India Corporation, No. 595, 2nd Floor, Dr. Mukherjee Nagar, New Delhi - 110 009, India; Tel: +(91)-(11)-27604500; Fax: +(91)-(11)27604600 Medifest India Dec 15-17, 2011 NASC Complex New Delhi, India It is an International Trade Fair and a unique opportunity for all related to medicine and healthcare field to reach new horizons of effective cooperation and discuss vital issues that stand presently in front of medical and healthcare industry. Vantage Trade Fairs (P) Limited, 38/16, 3rd Floor, East Patel Nagar, New Delhi, India. Tel: +(91)-(11)-25757181; Fax: +(91)-(11)-25757180 A joint Initiative by IPA and Cygnus to enable Pharma Professionals to be more successful Indian Pharmaceutical Association Kalina, Santacruz (E), Mumbai – 400 098. Tel: 91-22-26671072; Fax: 91-22-26670744, Email:ipacentre@ipapharma.org:: www.ipapharma.org Cygnus Business Consulting & Research Pvt. Ltd Plot No: 8-3-948/949, 1st Floor, Solitaire Plaza, Behind Image Hospital, Ameerpet, Hyderabad- 500 073. Tel: +91-40-23430203 & 04, Fax: +91-40-23435364, Email: info@cygnusindia.com; Website: www.cygnusindia.com 22