Preparation, characterization and atomic absorption spectroscopic determination of some metal complexes of glipizide Gamal A. Saleha, Samiha A. Husseina, Hassan R. H. Alia, Ahmed I. Hassanb a b Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-azhar University (Assiut Branch), Assiut 71524, Egypt. Abstract Glipizide is a commonly used sulfonylurea oral hypoglycemic drug. The present work reports the preparation and characterization of its metal complexes with cadmium, mercuric, ferric, zinc, cobalt, nickel and calcium. The existence of these complexes has been confirmed by FTIR spectroscopy, which revealed that formation of these complexes was in 2:1 stoichiometry of glipizide and each studied metal, respectively. Close FTIR inspection confirmed the co-ordination of nitrogen and carbonyl oxygen atom of –SO2NHCONH- moiety of glipizide with the studied metals. Further, the formed complexes have been analyzed using atomic absorption spectroscopy. The method was successfully applied for the indirect determination of glipizide in its dosage form for the first time.