Fabrication of Free-Standing Nanoporous Membranes for Biological Separations Dr. H.-K. Jeong Self-assembled nanoporous silica thin films with orthogonally aligned tunable nanochannels have great potential not only as excellent model systems for fundamental study on the transport of ions and molecules through confined nano-spaces but also as novel membranes for practical applications such as fuel cells and separation and detection of chemical and biological agents. The size, connectivity, and surface functionality (for instance, surface charge density) of the silica nanopores can be readily controlled. Thanks to the recent efforts by several groups, the orientation of the nano-channels can also be controlled such that the cylindrical nano-channels are aligned perpendicular to the substrates. Besides, Dr. Jeong’s group has already demonstrated the ability to fabricate free-standing nanoporous silica films on silicon wafers, a critical step to develop as nanoporous membranes for practical applications. The goal of the project is to systematically study molecular transport through nanochannels of free-standing nanoporous silica films on silicon wafers. Plane view Cross-sectional view SiO2 Mesoporous silica film Si wafer 20 nm ~ 2nm – 10nm