R.M. Kostrzewa, Ph.D.
May 2015
CURRICULUM VITA
Richard M. Kostrzewa, Ph.D.
Professor, Department of Biomedical Sciences
Quillen College of Medicine
East Tennessee State University
P.O. Box 70,577
Johnson City, TN 37614-1708, USA
PH:
+1 423 439-6321
FAX: +1 423 439-8044
Email: kostrzew@etsu.edu
Personal: United States Citizen, Married
Education/Degrees
Philadelphia College of Pharmacy & Science
Philadelphia College of Pharmacy & Science
University of Pennsylvania, Philadelphia, PA
Medical University of Silesia, Katowice, Poland
B.S. Chemistry
M.S. Pharmacology
Ph.D. Pharmacology
Doctor Honoris Causa
1965
1967
1971
2005
Positions
Research Pharmacologist, Veterans Administration Medical Center, New Orleans, LA, 1971-75
Adjunct Assistant Professor of Pharmacology, Tulane University Medical Center, New Orleans, LA, 1974-76
Graduate Faculty, Department of Psychology, University of New Orleans, New Orleans, LA, 1974-77
Assistant Professor of Physiology, Louisiana State University Medical Center, New Orleans, LA, 1975-78
Professor of Pharmacology/Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, 1984- ;
Associate Professor, 1978-84
Visiting Professor, Medical University of Silesia in Katowice, Poland, 1997-2003
Societies
Neurotoxicity Society, Founding Board, President (2001-03), Past-President (2003-05),
Treasurer (2005- Dec 2011), Council (2012-2015)
American Society of Pharmacology and Experimental Therapeutics (1975- present)
Federation of American Societies for Experimental Biology/Experimental Biology (1975-present)
Society for Neuroscience (1973- present)
Int’l Brain Research Organization (1984- present)
Histochemical Society (1980-89); Orthoquinone Club (1997- 2001); Society of Toxicology (1994-99)
Appalachian Chapter, Soc. Neuroscience: Organizer (1979), President (1980, 1987, 1989-2003)
Southeastern Pharmacology Society (1986-96; Councilor, 1989-91; 1994-6)
New Orleans Chapter, Soc. Neuroscience: Organizing Committee (1973), Secretary (1976), President (1978)
HONORS/AWARDS
2005 Doctor Honoris causa, Medical University of Silesia, Katowice, Poland.
2001 Honorary Membership, Polish Pharmacological Society
1997-2003 Visiting Professorship, Medical University of Silesia, Zabrze, Poland
1996 Fellow of the Japan Society for the Promotion of Science
1994 Designation of the Pharmacological Reviews article, "Pharmacological Actions of 6-Hydroxydopamine" (R.M.
Kostrzewa and D.M. Jacobowitz) among the 400 most-cited articles in the life sciences
1993 Designation of the Pharmacol. Reviews article as a Citation Classic in Current Contents
1992 Fellow of the John E. Fogarty International Center
1990 Fellow of the John E. Fogarty International Center
1981 Recipient, East Tennessee State University Foundation Research Award
JOURNAL AND BOOK EDITORIAL ACTIVITIES
1998 Founding Editor of the journal Neurotoxicity Research
1998-2017, Editor-in-Chief, Neurotoxicity Research. Impact Factor, 3.151 for 2013 (3.25, 5 yr average)
Editorial Boards: J. Neural Transmission, Neurochemical Research, Applied Cell Biology
2010 – present, Editor-in-Chief, Handbook of Neurotoxicity, Springer Science, New York.
2010 – present, co-Editor-in-Chief (with Trevor Archer, Gőteborg Univ., Sweden), Current Topics in
Neurotoxicity Springer Science Book series
R.M. Kostrzewa, Ph.D.
PUBLICATIONS
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Haugaard N, NH Lee, R Kostrzewa, ES Haugaard (1968) Effects of a disulfide (Ellman's reagent) and thiols on
oxidative phosphorylation and ion transport by rat liver mitochondria. Biochem. Pharmacol. 18, 2385-2391.
Haugaard N, NH Lee, R Kostrzewa, RS Horn, ES Haugaard (1969) The role of sulfhydryl groups in oxidative
phosphorylation and ion transport by rat liver mitochondria. Biochem. Biophys. Acta 172, 198-204.
Jacobowitz D, R Kostrzewa (1971) Selective action of 6-hydroxydopa on noradrenergic terminals: Mapping of
preterminal axons of the brain. Life Sci. 10, 1329-1341.
Kostrzewa R, D Jacobowitz (1972) The effect of 6-hydroxydopa on peripheral adrenergic neurons. J.
Pharmacol. Exp. Ther. 183, 284-297.
Kostrzewa R, D Jacobowitz (1973) Acute effects of 6-hydroxydopa on central monoaminergic neurons. Eur. J.
Pharmacol. 21, 70-80.
Kostrzewa RM, JW Harper (1974) Effects of 6-hydroxydopa on catecholamine-containing neurons in brains of
newborn rats. Brain Res. 69, 174-181.
Kostrzewa RM, DM Jacobowitz (1974) Pharmacological actions of 6-hydroxydopamine. Pharmacological
Reviews 26, 199-288.
Fingerman M, WE Julian, MA Spirtes, RM Kostrzewa (1974) The presence of 5-hydroxytryptamine in the
eyestalks and brain of the fiddler crab Uca pugilator, its quantitative modification by pharmacological agents,
and possible role as a neurotransmitter in controlling the release of red pigment-dispersing hormone. Gen.
Comp. Pharmacol. 5, 299-303.
Kostrzewa RM (1975) Effects of neonatal 6-hydroxydopa treatment on monamine content of rat brain and
peripheral tissues. Res. Commun. Chem. Pathol. Pharmacol. 11, 567-579.
Kostrzewa RM, JW Harper (1975) Comparison of the neonatal effects of 6-hydroxydopa and 6hydroxydopamine on growth and development of noradrenergic neurons in the central nervous system, in
Chemical Tools in Catecholamine Research (T Malmfors, G Jonsson, C Sachs, Eds), North Holland,
Amsterdam, pp. 181-189.
Spirtes MA, RM Kostrzewa, AJ Kastin (1975) Effect of melanocyte stimulating hormone (MSH) and MSHrelease inhibiting factor on levels and synthesis of serotonin in various brain regions of control and
hypophysectomized rats. Pharmacol. Biochem. Behav. 3, 1011-1016.
Kostrzewa RM, AJ Kastin, MA Spirtes (1975) Effects of MSH and MIF-I on activity of catecholaminecontaining neurons in rat brain. Pharmacol. Biochem. Behav. 3, 1017-1023.
Kastin AJ, NP Plotnikoff, CA Sandman, MA Spirtes, RM Kostrzewa, SM Paul, LO Stratton, LH Miller, F
Labrie, AV Schally, H Goldman (1975) The effects of MSH and MIF on the brain, in Anat. Neuroendocrinol.,
(WE Stumpf, LD Grant, Eds.), Karger, Basel, pp. 290-297.
McLean JH, RM Kostrzewa, JG May (1976) Behavioral and biochemical effects of neonatal treatment of rats
with 6-hydroxydopa. Pharmacol. Biochem. Behav. 4, 601-607.
Kostrzewa RM, RE Garey (1976) Effects of 6-hydroxydopa on noradrenergic neurons in developing rat brain.
J. Pharmacol. Exp. Ther. 197, 105-118.
Klara PM, RM Kostrzewa, KR Brizzee (1976) Destructive action of systemically administered 6hydroxydopamine on the rat area postrema. Brain Res. 104, 187-192.
Christensen CW, CT Harston, AJ Kastin, RM Kostrzewa, MA Spirtes (1976) Investigation of α-MSH and MIFI effects on cyclic AMP levels in rat brain. Pharmacol. Biochem. Behav. 5, Suppl. 1, 117-120.
Spirtes MA, NP Plotnikoff, RM Kostrzewa, CT Harston, AJ Kastin, CW Christensen (1976) Possible
association of increased rat behavioral effects and increased striatal dopamine and norepinephrine levels during
the DOPA-potentiation test. Pharmcol. Biochem. Behav. 5, Suppl. 1, 121-124.
Kostrzewa RM, MA Spirtes, JW Klara, CW Christensen, AJ Kastin, TH Joh (1976) Effects of L-prolyl-Lleucyl-glycine amide (MIF-I) on dopaminergic neurons. Pharmacol. Biochem. Behav. 5, Suppl. 1, 125-127.
McLean JH, RM Kostrzewa, JG May (1976) Minimal brain dysfunction: dopamine depletion? Science 194,
451. [Letter]
Kostrzewa RM, RE Garey (1977) Sprouting of noradrenergic terminals in rat cerebellum following neonatal
treatment with 6-hydroxydopa. Brain Res. 124, 385-391.
Christensen CW, MA Spirtes, RM Kostrzewa, AJ Kastin (1978) Neuro- pharmacological aspects of
hypothalamic peptides and α-MSH, In Current Studies of Hypothalamic Functions, Vol. 1 Hormones (K
Lederis, S Karger, Eds), Basel.
Kostrezewa RM, JW Klara, J Robertson, LC Walker (1978) Studies on the mechanism of sprouting of
noradrenergic terminals in rat and mouse cerebellum after neonatal 6-hydroxydopa. Brain Res. Bull. 3, 525-531.
Kostrzewa RM, AJ Kastin, SK Sobrian (1978) Potentiation of apomorphine actions in rats by L-prolyl-L-leucylglycine amide. Pharmacol. Biochem. Behav. 9, 375-378.
R.M. Kostrzewa, Ph.D.
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Kostrzewa RM, MB Clark, H Fukushima (1979) Regenerative sprouting of noradrenergic terminals in the
cerebellum, In Catecholamines: Basic and Clinical Frontiers, (E Usdin, IJ Kopin, J Barchas, Eds.), Pergamon
Press, New York, pp. 797-799.
Clark MB, JC King, RM Kostrzewa (1979) Loss of nerve cell bodies in caudal locus coeruleus following
treatment of neonates with 6-hydroxydopa. Neurosci. Lett. 13, 331-336.
Kastin AJ, RH Ehrensing, DH Coy, AV Schally, RM Kostrzewa (1979) Behavioral effects of brain
peptides, including LH-RH, in Psychoneuroendocrinology in Reproduction (L Zichella, P Pancheri, Eds),
Elsevier, North Holland, pp. 69-80.
Morgan DN, JH McLean, RM Kostrzewa (1979) Effects of 6-hydroxydopamine and 6-hydroxydopa on
development of behavior. Pharmacol. Biochem. Behav. 11, 309-312.
Kostrzewa RM, J Hardin, RL Snell, AJ Kastin, DH Coy, F Bymaster (1979) MIF-I and postsynaptic receptor
sites for dopamine. Brain Res. Bull. 4, 657-662.
Kostrzewa RM, H Fukushima, CT Harston, KW Perry, RW Fuller, AJ Kastin (1979) Striatal dopamine turnover
and MIF-I. Brain Res. Bull. 4, 799-802.
Kastin AJ, AV Schally, RM Kostrzewa (1980) Possible aminergic mediation of MSH release and of the CNS
effects of MSH and MIF-I. Fed. Proc. 39, 2931-2936.
Harston CT, A Morrow, RM Kostrzewa (1980) Enhancement of sprouting and putative regeneration of central
noradrenergic fibers by morphine. Brain Res. Bull. 5, 421-424.
Kostrzewa RM, H Fukushima, A Morrow, P Cohenour, T Hsi, RE Lehr, CL Blank (1980) α-Methyl-6aminodopamine: Depletion of catecholamines in mouse brain and peripheral tissues. Life Sci. 27, 2245-2250.
McLean JH, RS Glasser, RM Kostrzewa, JG May (1980) Effects of neonatal 6-hydroxydopa on behavior in
female rats. Pharmacol. Biochem. Behav. 13, 863-868.
Kastin AJ, RM Kostrzewa, AV Schally, DH Coy (1980) Neonatal administration of met-enkephalin facilitates
maze performance of adult rats. Pharmacol. Biochem. Behav. 13, 883-886.
Walker LC, AA Gerall, RM Kostrzewa (1980) Rostral midbrain lesions and copulatory behavior in male rats.
Physiol. Behav. 26, 349-353.
Harston CT, MB Clark, JC Hardin, RM Kostrzewa (1981) Opiate-enhanced toxicity and noradrenergic
sprouting in rats treated with 6-hydroxydopa. Eur. J. Pharmacol. 71, 365-373.
Harston CT, MB Clark, JC Hardin, RM Kostrzewa (1982) Developmental localization of noradrenergic
innervation to the rat cerebellum following neonatal 6-hydroxydopa and morphine treatment. Dev. Neurosci. 5,
252-262.
Kostrzewa RM, CT Harston, H Fukushima, R Brus (1982) Noradrenergic fiber sprouting in the cerebellum.
Brain Res. Bull. 9, 509-517.
Kostrzewa RM, D Klisans-Fuenmayor (1984) Development of an opioid- specific action of morphine in
modifying recovery of neonatally-damaged noradrenergic fibers in rat brain. Res. Commun. Chem. Pathol.
Pharmacol. 46, 3-11.
Klisans-Fuenmayor D, CT Harston, RM Kostrzewa (1986) Alterations in noradrenergic innervation of the brain
following dorsal bundle lesions in neonatal rats. Brain Res. Bull. 16, 47-54.
Heydorn WE, KQ Nguyen, GJ Creed, RM Kostrzewa, DM Jacobowitz (1986) Effects of bilateral lesion of the
locus coeruleus and of neonatal administration of 6-hydroxydopamine on the concentration of individual
proteins in rat brain. Brain Res. 367, 31-38.
Kostrzewa RM, CT Harston (1986) Altered histofluorescent pattern of noradrenergic innervation of the
cerebellum of the mutant mouse Purkinje cell degeneration. Neuroscience 8, 809-815.
Kostrzewa RM, JC Hardin, DM Jacobowitz (1988) Destruction of cells in the midportion of the locus coeruleus
by a dorsal bundle lesion in neonatal rats. Brain Res. 442, 321-328.
Kostrzewa RM (1988) Reorganization of noradrenergic neuronal systems following neonatal chemical and
surgical injury. Progr. Brain Res. 78, 405-423.
Saleh MI, RM Kostrzewa (1988) Impaired striatal dopamine receptor development: Differential D-1 regulation
in adults. Eur. J. Pharmacol. 154, 305-311.
Kostrzewa RM, MI Saleh (1989) Impaired ontogeny of striatal dopamine D1 and D2 binding sites after postnatal
treatment of rats with SCH-23390 and spiroperidol. Dev. Brain Res. 45, 95-101.
Saleh MI, RM Kostrzewa (1989) MIF-1 attenuates spiroperidol alteration of striatal dopamine D 2 receptor
ontogeny. Peptides 10, 35-40.
Kostrzewa RM (1989) Neurotoxins that affect central and peripheral catecholamine neurons, In Neuromethods,
vol. 12, Neuropharmacology Section, (AA Boulton, GB Baker, AV Juorio, Eds.), Humana Press, Totowa, NJ,
pp. 1-48.
Kostrzewa RM, TG White, JE Zadina, AJ Kastin (1989) MIF-1 attenuates apomorphine stereotypies in adult
rats after neonatal 6-hydroxydopamine. Eur. J. Pharmacol. 163, 33-42.
R.M. Kostrzewa, Ph.D.
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Kostrzewa RM, MI Saleh (1989) Attenuation of SCH-23390-induced alteration of striatal dopamine D-1
receptor ontogeny by prolyl-leucyl-glycinamide in the rat. Neuropharmacol. 28, 805-810.
Kostrzewa RM, A Hamdi, FP Kostrzewa (1990) Production of prolonged supersensitization of dopamine
D2 receptors. Eur. J. Pharmacol. 183, 1411-1412.
Arbogast LY, JK Neumann, RM Kostrzewa, BW Arbogast (1990) Decreased VLDL preventing activity in
response to a reverse mirror drawing stressor. SAAS Bull. Biochem. and Biotech. 3, 80-84.
Kostrzewa RM, A Hamdi (1991) Potentiation of spiroperidol-induced oral activity in rats after neonatal 6hydroxydopamine. Pharmacol. Biochem. Behav. 38, 215-218.
Neumann JK, DS Chi, BW Arbogast, RM Kostrzewa, LM Harvill (1991) Relationship between blood groups
and behavior patterns in men who have had myocardial infarction. Southern Med. J. 84, 214-218.
Kostrzewa RM (1991) Career planning for pharmacologist trainees. The Pharmacologist 33, 41-45.
Kostrzewa RM, R Brus (1991) Is dopamine-agonist induced yawning behavior a D3 mediated event?
Pharmacol. Lett. section of Life Sci. 48, PL-129.
Kostrzewa RM, R Brus (1991) Ontogenic homologous supersensitization of quinpirole-induced yawning in rats.
Pharmacol. Biochem. Behav. 39, 517-519.
Kostrzewa RM, L Gong (1991) Supersensitized D1 receptors mediate enhanced oral activity after neonatal 6OHDA. Pharmacol. Biochem. Behav. 39, 677-682.
Hamdi A, RM Kostrzewa (1991) Ontogenic homologous supersensitization of dopamine D1 receptors. Eur. J.
Pharmacol. 203, 115-120.
Gong L, EA Daigneault, RV Acuff, RM Kostrzewa (1991) Vitamin E supplements fail to protect mice from
acute MPTP neurotoxicity. Neuroreport 2, 544-546.
Kostrzewa RM, R Brus, J Kalbfleisch (1991) Ontogenetic homologous sensitization to the antinociceptive
action of quinpirole in rats. Eur. J. Pharmacol. 209, 157-161.
Gong L, RM Kostrzewa (1992) Supersensitized oral response to a serotonin agonist in neonatal 6-OHDA
treated rats. Pharmacol. Biochem. Behav. 41, 621-623.
Gong L, RM Kostrzewa, RW Fuller, KW Perry (1992) Supersensitization of the oral response to SKF 38393 in
neonatal 6-OHDA-lesioned rats is mediated through a serotonin system. J. Pharmacol. Exp. Ther. 261, 10001007.
Kostrzewa RM, R Brus, DH Coy, H Criswell, PS Coogan, AJ Kastin (1992) D-Ala2,F5Phe4-dynorphin amide,
an opiate with analgesic and lethal properties. Pol. J. Pharm. Pharmacol. 44, 109-120.
Chi DS, L Gong, EA Daigneault, RM Kostrzewa (1992) Effects of MPTP and vitamin E treatments on immune
function in mice. Int. J. Immunopharmacol. 14, 739-746.
Kostrzewa RM, L Gong, R Brus (1992) Serotonin (5-HT) systems mediate dopamine (DA) receptor
supersensitivity. Acta Neurobiol. Exp. 53, 31-41.
Kostrzewa RM, R Brus, M Rykaczewska, A Plech (1993) Low dose quinpirole ontogenically sensitizes to
quinpirole-induced yawning in rats. Pharmacol. Biochem. Behav. 44, 487-489.
Kostrzewa RM, D Neely (1993) Enhanced pilocarpine-induced oral activity responses in neonatal 6-OHDAtreated rats. Pharmacol. Biochem. Behav. 45, 737-740.
Kostrzewa RM, AJ Kastin (1993) Tyr-MIF-1 attenuates development of tolerance to spiperone-induced
catalepsy in rats. Brain Res. Bull. 31, 707-712.
Kostrzewa RM, J Guo, FP Kostrzewa (1993) Ontogenetic quinpirole treatments induce vertical jumping activity
in rats. Eur. J. Pharmacol. 239, 183-187.
Gong L, RM Kostrzewa, R Brus, RW Fuller, KW Perry (1993) Ontogenetic SKF 38393 treatments sensitize
dopamine D1 receptors in neonatal 6-OHDA-lesioned rats. Dev. Brain Res. 76, 59-65.
Kostrzewa RM, R Brus, KW Perry, RW Fuller (1993) Age-dependence of a 6-hydroxydopamine lesion on SKF
38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. Dev. Brain Res. 76, 87-93.
Gong L, RM Kostrzewa, J Kalbfleisch (1993) MIF-1 fails to modify agonist-induced oral activity in neonatal 6OHDA treated rats. Peptides 14, 1159-1164.
Kostrzewa RM (1993) Altered sensitivity of recognition sites for catecholamines in the absence of changes in
receptor binding parameters, in Botulinum and Tetanus Neurotoxins: Neurotransmission and Biomedical
Aspects (G DasGupta, Ed.), Plenum Press, pp. 521-537.
Gong L, RM Kostrzewa, KW Perry, RW Fuller (1993) Dose-related effects of a neonatal 6-OHDA lesion on
SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. Dev. Brain Res. 76, 233238.
Kostrzewa RM (1993) “A Citation Classic: Pharmacology of 6-Hydroxydopamine”, in Current Contents
Life Sciences vol. 36 (no. 32), p. 9. For the article by RM Kostrzewa and DM Jacobowitz, Pharmacol.
Reviews 26, 199-288, 1974. [590 citations through 1992].
R.M. Kostrzewa, Ph.D.
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Arbogast BW, JK Newmann, LY Arbogast, SC Leeper, RM Kostrzewa (1994) Transient loss of serum
protective activity following short term stress: a possible chemical link between stress and atherosclerosis. J.
Psychosom. Res. 38, 871-884.
Huang N, RM Kostrzewa (1994) Enhanced oral activity response to A77636 in neonatal 6-hydroxydopaminelesioned rats. Eur. J. Pharmacol. 253, 163-166.
Kostrzewa RM, R Brus, JH Kalbflesich, KW Perry, RW Fuller (1994) Proposed animal model of attention
deficit hyperactivity disorder. Brain Res. Bull. 34, 161-167.
Gong L, RM Kostrzewa, C Li (1994) Neonatal 6-OHDA and adult SKF 38393 treatments alter dopamine D1
receptor mRNA levels: Absence of other neurochemical associations with the enhanced behavioral responses of
lesioned rats. J. Neurochem. 63, 1282-1290.
The 1974 Pharmacological Reviews article by RM Kostrzewa and DM Jacobowitz, `Pharmacological
Actions of 6-Hydroxydopamine' was ranked by Current Contents in 1994 among the 400 most-cited
articles in the life sciences.
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Brus R, RM Kostrzewa, KW Perry, RW Fuller (1994) Supersensitization of the oral response to SKF 38393 in
neonatal 6-hydroxydopamine-lesioned rats is eliminated by neonatal 5,7-dihydroxytryptamine treatment. J.
Pharmacol. Exp. Ther. 268, 231-237.
Huang N-Y, RM Kostrzewa (1994) Persistent oral dyskinesias in haloperidol-withdrawn neonatal 6-OHDAlesioned rats. Eur. J. Pharmacol. 271, 433-437.
Kostrzewa RM (1995) Dopamine receptor supersensitivity. Neurosci. Biobehav. Rev. 19, 1-17.
Brus R, R Kostrzewa, W Felińska, A Plech, R Szkilnik, J Frydrych (1995) Ethanol inhibits cadmium
accumulation in brains of offspring of pregnant rats that consume cadmium. Toxicol. Lett. 76, 57-62.
Brus R, A Plech, RM Kostrzewa (1995) Enhanced quinpirole responses in rats lesioned neonatally with 5,7dihydroxytryptamine. Pharmacol. Biochem. Behav. 50, 649-653.
W Felińska, R Brus, R Szkilnik, M Rykaczewska, A Plech, RM Kostrzewa, J Frydrych (1995) Cadmium
modulates reactivity of central dopamine receptors in rats prenatally exposed to ethanol. Pol. J. Environ.
Studies 4, 31-36.
Jędrusiak J, R Brus, RM Kostrzewa, Z Słowinski (1995) Dopaminergic neuronal systems modulate the central
cardiovascular effects of TRH in rats. Pol. J. Pharmacol. 47, 43-52.
Brus R, W Felińska, M Rykaczewska, RM Kostrzewa, R Szkilnik, A Plech (1995) Prenatal ethanol diminishes
reactivity of presumed dopamine D3 receptors in rats. Pol. J. Pharmacol. 47, 109-114.
Plech A, R Brus, JH Kalbfleisch, RM Kostrzewa (1995) Enhanced oral activity responses to intrastriatal SKF
38393 and m-CPP are attenuated by intrastriatal mianserin in neonatal 6-OHDA-lesioned rats.
Psychopharmacol. 119, 466-473.
Perry KW, RM Kostrzewa, RW Fuller (1995) Persistence of long-lasting serotonin depletion by pchloroamphetamine in rat brain after 6-hydroxydopamine lesioning of dopamine neurons. Biochem. Pharmacol.
50, 1305-1307.
Brus R, R Szkilnik, RM Kostrzewa, A Plech, M Rykaczewska, P Nowak, J Shani (1995) Reactivity of central
dopamine receptors after an electric shock in male and female rats. Pharmacol. Commun. 7, 79-86.
Brus R, R Szkilnik, RM Kostrzewa, J Jędrusiak, J Konecki, M Glowacka, J Shani (1995) Modulation of glucose
uptake in rat brain after administration of quinpirole and SKF 38393, two central dopamine-receptor agonists.
Pharmacol. Commun. 7, 87-91.
Ma S, L Lin, R Rhagavan, P Cohenour, PYT Lin, J Bennett, RJ Lewis, EL Enwall, R Kostrzewa, RE Lehr, CL
Blank (1995) In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs. J. Med.
Chem. 38, 4087-4097.
Brus R, R Szkilnik, RM Kostrzewa (1996) Nitric oxide (NO) and central dopamine (DA) D3 receptor reactivity
in rats. Acta Neurobiol. Exp. 56, 15-19.
Kostrzewa RM, R Brus, KW Perry, RW Fuller (1996) Dopamine and 5-HT receptor sensitivity does not
correlate with neostriatal dopamine or 5-HT content. Acta Neurobiol. Exp. 56, 21-28.
Brus R, RM Kostrzewa, R Szkilnik, W Felinska, A Plech (1996) Prenatal ethanol exposure impairs dopamine
D2 and serotonin agonist effects in rats. Pharmacol. Rev. Commun. 8, 285-290.
Huang N-Y, RM Kostrzewa, C Li, KW Perry, RW Fuller (1997) Persistent spontaneous oral dyskinesias in
haloperidol-withdrawn rats neonatally lesioned with 6-hydroxydopamine: Absence of an association with the
Bmax for [3H]raclopride binding to neostriatal homogenates. J. Pharmacol. Exp. Ther. 280, 268-276.
Brus R, R Szkilnik, RM Kostrzewa (1997) Quinpirole-induced yawning behavior in rats neonatally pretreated
with 6-hydroxydopamine (6-OHDA) and 5,7-dihydroxytryptamine (5,7-DHT). Med. Sci. Monitor 3, 324-327.
R.M. Kostrzewa, Ph.D.
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Brus R, R Szkilnik, P Nowak, RM Kostrzewa (1997) Nitro-L-arginine attenuates SKF 38393-induced oral
activity in neonatal 6-hydroxydopamine-lesioned rats. Acta Neurobiol. Exp. 57, 283-287.
100. Brus R, R Szkilnik, I Popieluch, RM Kostrzewa, K Mengel (1997) Effect of aluminum exposure on central
serotonin and muscarine receptor reactivity in rats. Med. Sci. Monitor 3, 631-636.
101. Kostrzewa RM (1998) 6-Hydroxydopa, a catecholamine neurotoxin and endogenous excitotoxin at non-NMDA
receptors, In Highly Selective Neurotoxins: Basic and Clinical Applications (RM Kostrzewa, Ed.), Humana
Press, Totowa NJ, pp. 109-129.
102. Kostrzewa RM (1998) Observations relative to the neurotoxicity and neurotoxic potential of amino acids.
Amino Acids 13, 171-173.
103. Kostrzewa RM, R Brus (1998) Destruction of catecholamine-containing neurons by 6-hydroxydopa, an
endogenous amine oxidase cofactor. Amino Acids 14, 175-179.
104. Kostrzewa RM, TA Reader, L Descarries (1998) Serotonin neural adaptations to ontogenetic loss of
dopamine neurons in rat brain. J. Neurochem. 70, 889-898.
105. Brus R, R Szkilnik, P Nowak, A Kasperska, J Oświęcimska, RM Kostrzewa, J Shani (1998) Locomotor
sensitization of dopamine receptors by their agonists quinpirole and SKF-38393, during maturation and aging in
rats. Pharmacol. Rev. Commun. 10, 25-30.
106. Brus R, R Szkilnik, P Nowak, R Kostrzewa, J Shani (1998) Sensitivity of central dopamine receptors in rats to
quinpirole and SKF-38393, administered at their early stages of ontogenicity, evaluated by learning and
memorizing a conditioned avoidance reflex. Pharmacol. Rev. Commun. 10, 31-36.
107. Brus R, P Nowak, R Szkilnik, RM Kostrzewa, J Shani (1998) Induction of grooming behavior in male rats by
m-chlorophenylpiperazine, a central 5-hydroxytryptamine receptor agonist. Pharmacol. Rev. Commun. 10, 3742.
108. Kostrzewa RM, R Brus, KW Perry (1999) Interactive modulation by dopamine and serotonin neurons of
receptor sensitivity of the alternate neurochemical system. Pol. J. Pharmacol. 5, 39-47.
109. Tizabi Y, RL Copeland Jr, R Brus, RM Kostrzewa (1999) Nicotine blocks quinpirole-induced behavior in rats:
psychiatric implications. Psychopharmacol. 145, 433-441.
110. Kostrzewa RM (1999) Editorial. Neurotoxicity Res. 1, 1-2.
111. Kostrzewa RM (1999) Selective neurotoxins, chemical tools to probe the mind: the first thirty years and beyond.
Neurotoxicity Res. 1, 3-25.
112. Kasperska A, R Brus, R Szkilnik, J Oświęcimska, RM Kostrzewa, J Shani (1999) Modulation of central
dopamine receptor reactivity in the rat, by nitric oxide donors and inhibitor: Behavioral studies. Pharmacol.
Rev. Commun. 10, 311-319.
113. Kasperska A, R Brus, A Sokoła, RM Kostrzewa, J Shani (1999) Sexual differentiation in the central
dopaminergic effect of nitric oxide donors and inhibitor on stereotype behavior changes induced by
amphetamine, but not by apomorphine. Pharmacol. Rev. Commun. 10, 329-339.
114. Kostrzewa RM, JP Kostrzewa, R Brus (2000) Dopaminergic denervation enhances susceptibility to hydroxyl
radicals in rat neostriatum. Amino Acids 19, 183-199.
115a. Kostrzewa RM (2000) Review on apoptosis vs. necrosis of substantia nigra pars compacta in
Parkinson’s disease. Neurotoxicity Res. 2, 239-250.
115b. Kostrzewa RM (2001) Review on apoptosis vs. necrosis of substantia nigra pars compacta in Parkinson’s
disease, In Strategies for Studying Brain Disorders 5: Neurodegenerative Brain Disorders (T Palomo, T
Archer, RJ Beninger, Eds.), Fundación Cerebro y Mente, Madrid, Spain, pp. 755-768.
116. Oświęcimska J, R Brus, R Szkilnik, P Nowak, RM Kostrzewa (2000) 7-OH-DPAT, unlike quinpirole, does not
prime a yawning response in rats. Pharmacol. Biochem. Behav.67, 11-15.
117. Kostrzewa RM (2000) Crucial role of iron in anesthesia. Commentary in Psycoloquy 11, issue 032, article 3.
(http://www.cogsci.soton.ac.uk/psyc...article=11.032&submit=View+Article)
118. Beal MF, T Palomo, RM Kostrzewa, T Archer (2000) Neuroprotective and neurorestorative strategies for
neuronal injury. Neurotoxicity Res. 2, 71-84.
119. Archer T, T Palomo, RM Kostrzewa (2001) Neurotoxicity and substance abuse: further fuel for regulatory
dilemma. Neurotoxicity Res. 3, 1-6.
120. Kostrzewa RM (2001) Mechanisms of action of 6-hydroxydopamine, a dopaminergic neurotoxin, In
Mechanisms of Degeneration and Protection of the Dopaminergic System (Segura-Aguilar J, Ed.), FP Graham
Publishing Co., New York, pp. 85-104.
121. Palomo T, RJ Beninger, K Jhamandas, RM Kostrzewa, MF Beal, T Archer (2001) Protective and Restorative
Strategies in the Neurodegenerative Disorders, in Neurodegenerative Brain Disorders (T Palomo, T Archer, RJ
Beninger, Eds.), Fundación Cerebro y Mente, Madrid, Spain, pp. 481-500.
122. Nowak P, R Brus, RM Kostrzewa (2001) Amphetamine-induced enhancement of neostriatal in vivo
microdialysate dopamine content in rats, quinpirole-primed as neonates. Pol. J. Pharmacol. 53, 319-329.
R.M. Kostrzewa, Ph.D.
123.
124.
125.
126.
127.
128.
129.
130.
131.
132.
133.
134.
135.
136.
137.
138.
139.
140.
141.
142.
143.
144.
145.
146.
Oświęcimska J, R Brus, R Szkilnik, A Sokola, RM Kostrzewa, J Shani (2001) Sexual differentiation in
behavioral patterns of rats, pretreated with two central dopamine agonists: quinpirole and 7-OH-DPAT.
Pharmacol. Rev. Commun. 11, 203-213.
Kretschmer BD, WJ Schmidt, RM Kostrzewa, M Herrera-Marschitz (2002) Amino acids in neurobiology:
neuroprotective and neurotoxic aspects of amino acids involved in neurotransmission and neuromodulation.
Amino Acids 23, 1-7.
Kostrzewa RM, JP Kostrzewa, R Brus (2002) Novel roles of amino acids and analogues in neurodegenerative
disorders. Amino Acids 23, 55-56.
Kostrzewa RM, JP Kostrzewa, R Brus (2002) Neuroprotective and neurotoxic roles of levodopa (L-DOPA) in
neurodegenerative disorders relating to Parkinson’s disease. Amino Acids 23, 57-63.
Kostrzewa RM, J Segura-Aguilar (2002) Neurotoxicological and neuroprotective elements in Parkinson’s
disease. Neurotoxicity Res. 4, 83-86.
Brown RW, JT Gass, RM Kostrzewa (2002) Ontogenetic quinpirole treatments produce spatial memory deficits
and enhance skilled reaching in adult rats. Pharmacol. Biochem. Behav. 72, 591-600.
Brus R, P Nowak, A Sokoła, RM Kostrzewa, J Shani (2002) Behavioral and biochemical effects of new central
dopamine D3 and D4 receptor antagonists in rats. Pharmacol. Rev. Commun. 12, 39-59.
Brus R, P Nowak, A Sokoła, Ł Labus, J Oświęcimska, H. Winiarska, RM Kostrzewa, J Shani (2002) Exposure
of pregnant rats to manganese: effect on levels, turnover and release of biogenic amines in brains of their
offspring. Pharmacol. Rev. Commun. 12, 61-75.
Nowak P, R Brus, J Oświęcimska, A Sokoła, RM Kostrzewa (2002) 7-Nitroindazole enhances amphetamineevoked dopamine release in rat striatum. An in vivo microdialysis and voltammetric study. J. Physiol.
Pharmacol. 53, 251-263.
Palomo T, T Archer, RJ Beninger, RM Kostrzewa (2002) Neurodevelopmental liabilities of substance abuse.
Neurotoxicity Res. 4, 267-279.
Palomo T, RM Kostrzewa, T Archer, RJ Beninger (2002) Neurodevelopmental liabilities in schizophrenia and
affective disorders. Neurotoxicity Res. 4, 397-408.
Palomo T, RJ Beninger, RM Kostrzewa, T Archer (2003) Brain sites of movement disorder: Genetic and
environmental agents in neurodevelopmental perturbations. Neurotoxicity Res. 5, 1-26.
Kostrzewa RM, JP Kostrzewa, R Brus (2003) Dopamine receptor supersensitivity: an outcome and index of
neurotoxicity. Neurotoxicity Res. 5, 111-118.
Brus R, RM Kostrzewa, P Nowak, KW Perry, JP Kostrzewa (2003) Ontogenetic quinpirole treatments fail to
prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats. Neurotoxicity Res.
5(5), 329-338.
Kostrzewa RM, J Segura-Aguilar (2003) Novel mechanisms and approaches in the study of neurodegeneration
and neuroprotection. A review. Neurotoxicity Res. 5(6), 375-384.
Brown RW, KD Thompson, KN Thompson, JJ Ward, SK Thacker, ML Williams, RM Kostrzewa (2004)
Nicotine treatment in adulthood alleviates cognitive and skilled reaching impairments in rats treated during early
development with quinpirole: Interactions of dopamine D2 receptor sensitivity, acetylcholine function, and
neurotrophic factor expression. Eur. J. Neurosci. 19(6), 1634-1642.
Moy SS, A Fernandes, Y Qian, DL Rotella, RM Kostrzewa, GR Breese (2004) Effect of acute and chronic
olanzapine treatment on phencyclidine-induced behavioral sensitization in rats with neonatal dopamine loss.
Pharmacol. Biochem. Behav. 78(1), 47-56.
Kostrzewa RM, P Nowak, JP Kostrzewa, RA Kostrzewa, R Brus (2004) Dopamine D2 agonist priming in intact
and dopamine-lesioned rats. Neurotoxicity Res. 6, 457-462.
Palomo T, T Archer, RM Kostrzewa, RJ Beninger (2004) Gene-environment interplay in schizopsychotic
disorders. Neurotoxicity Res. 6, 1-9.
Palomo T, RJ Beninger, RM Kostrzewa, T Archer (2004) Gene-environment interplay in affect and dementia:
emotional modulation of cognitive expression in personal outcomes. Neurotoxicity Res. 6, 159-173.
Sieroń A, Ł Labus, P Nowak, G Cieślar, H Brus, A Durczok, T Zagził, RM Kostrzewa, R Brus (2004)
Alternating extremely low frequency magnetic field increases turnover of dopamine and serotonin in rat frontal
cortex. Bioelectromagnetics 25, 426-430.
Brus R, P Nowak, R Szkilnik, U Mikołajun, RM Kostrzewa (2004) Serotoninergics attenuate hyperlocomotor
activity in rats. Potential new therapeutic strategy for hyperactivity. Neurotoxicity Res. 6, 317-325.
Palomo T, RM Kostrzewa, RJ Beninger, T Archer (2004) Gene-environment interplay in alcoholism and other
substance abuse disorders: expressions of heritability and factors influencing vulnerability. Neurotoxicity Res. 6,
343-361.
Palomo T, T Archer, RJ Beninger, RM Kostrzewa (2004) Gene-environment interplay in neurogenesis and
neurodegeneration. Neurotoxicity Res. 6, 415-434. Review.
R.M. Kostrzewa, Ph.D.
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166.
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Segura-Aguilar J, RM Kostrzewa (2004) Neurotoxins and neurotoxic species implicated in neurodegeneration.
Neurotoxicity Res. 6, 615-630.
Herrera-Marschitz M, BD Kretschmer, RM Kostrzewa (2005) General Introduction: Neurobiology at the 8th
International Congress on Amino Acids and Proteins, Rome, Italy, September 2003. Amino Acids 28(2), 119121.
Kretschmer BD, RM Kostrzewa, M Herrera-Marschitz (2005) Introduction: Vulnerability of the CNS to
metabolic and drug-related insults. Amino Acids 28(2), 123-125.
Durczok A, R Szkilnik, P Nowak, Ł Labus, J Dąbrowska, A Bortel, T Zagził, M Swoboda, W Rycerski, H
Winnicka, RM Kostrzewa, R Brus (2005) The effect of zinc on the central dopaminergic system of rats
prenatally exposed to cadmium. Pol. J. Environ. Studies 14(5) 569-576.
Kostrzewa RM, P Nowak, JP Kostrzewa, RA Kostrzewa, R Brus (2005) Peculiarities of L-DOPA treatment
of Parkinson's disease. Amino Acids 28(2), 157-164. Epub 2005 Mar 9.
Nowak P, RM Kostrzewa, A Kwięcinski, A Bortel, Ł Labus and R Brus (2005) Neurotoxic action of 6hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine. J.
Physiol. Pharmacol. 56(2), 325-333.
Kuballa G, P Nowak, Ł Labus, A Bortel, J Dąbrowska, M Swoboda, A Kwieciński, RM Kostrzewa, R Brus
(2005) Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol
and clozapine. Pharmacol. Reports 57, 161-169.
Kostrzewa RM, JP Kostrzewa, R Brus, RA Kostrzewa, P Nowak (2006) Proposed animal model of severe
Parkinson’s disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum. J. Neural
Transm. [Suppl.] 70, 277-279.
Nowak P, Ł Labus, RM Kostrzewa, R Brus (2006) DSP-4 prevents dopamine receptor priming by
quinpirole. Pharmacol. Biochem. Behav. 84, 3-7.
Nowak P, J Dąbrowska, A Bortel, B Izabela, RM Kostrzewa, R Brus (2006) Prenatal cadmium and ethanol
increase amphetamine-evoked dopamine release in rat striatum. Neurotoxicol. Teratol. 28, 563-572.
Nowak P, J Dąbrowska, A Bortel, I Biedka, G Słomian, RM Kostrzewa, R Brus (2006) Histamine H3
receptor agonist- and antagonist-evoked vacuous chewing movements in 6-OHDA-lesioned rats occurs in
an absence of change in microdialysate dopamine levels. Eur. J. Pharmacol. 552(1-3), 46-54. Epub 2006
Sep 16.
Konecki J, G Bielaczyc, P Nowak, R Szkilnik, G Szczerbak, M Swoboda, A Kwieciński, RM Kostrzewa, R
Brus (2006) Effect of pre- and postnatal exposure to zinc on [3H]glucose uptake in the brain and peripheral
tissues of adult rats. Pol. J. Environ. Studies 15, 291-295.
Nowak P, T Zagził, J Konecki, G Szczerbak, R Szkilnik, J Niwiński, J Gorzałek, RM Kostrzewa, R Brus
(2006) Trimetazidine increases [3H]glucose uptake in rat brain. Pharmacol. Reports 58, 559-561.
Nowak P, G Szczerbak, I Biedka, M Drosik, RM Kostrzewa, R Brus (2006) Effect of ketanserin and
amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo
microdialysis study. J. Physiol. Pharmacol. 57, 583-597.
Nowak P, J Konecki, G Kuballa, R Szkilnik, A Kwieciński, G Szczerbak, M Drosik, J Gorzałek, J
Niwiński, Ł Noras, RM Kostrzewa, R Brus (2006) Effect of the dopamine D3 receptor antagonist
nafadotride on [3H]glucose uptake in the brain and peripheral tissues of rats – comparison with haloperidol
and clozapine. Ann. Acad. Med. Silesia 60 (6), 269-273.
Thacker SK, MK Perna, JJ Ward, TL Schaefer, MT Williams, RM Kostrzewa, RW Brown (2006) The
effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male
and female rats neonatally treated with quinpirole. Eur. J. Neurosci. 24(7), 2075-2083.
Segura-Aguilar J, RM Kostrzewa (2006) Neurotoxins and neurotoxicity mechanisms. Neurotoxicity Res. 10,
263-290.
Nowak P, G Szczerbak, J Dąbrowska, A Bortel, I Biedka, RM Kostrzewa (2006) Molecular mechanisms of
levodopa action in animal models of Parkinson’s disease. Neurol Neurochir Pol. (Pol. J. Neurol.
Neurosurg.) 40, 517-525.
Kostrzewa RM, N-Y Huang, JP Kostrzewa, P Nowak, R Brus (2007) Modeling tardive dyskinesia:
predictive 5-HT2C receptor antagonist treatment. Neurotoxicity Res. 11(1), 41-50.
Nowak P, A Bortel, J Dąbrowska, J Oświęcimska, M Drosik, A Kwieciński, J Opara, RM Kostrzewa, R
Brus (2007) Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in
an animal model of hyperactivity. Neurotoxicity Res. 11(2), 131-144.
Xu X, CC Chua, J Kong, RM Kostrzewa, U Kumaraguru, RC Hamdy, BHL Chua (2007) Necrostatin-1
protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells.
J. Neurochem.103(5), 2004-2014. Epub 2007 Aug 30.
R.M. Kostrzewa, Ph.D.
168.
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187.
188.
189.
190.
Szczerbak G, P Nowak, RM Kostrzewa, R Brus (2007) Maternal lead exposure produces long-term
enhancement of dopaminergic reactivity in rat offspring. Neurochem. Res. 32, 1791-1798.
Sieroń A. H Brus, J Konecki, G Cieślar, R Szkilnik, P Nowak, Ł Noras, A Kwieciński, RM Kostrzewa, R
Brus (2007) Pol. J. Environ. Stud. 16, 309-312. Letter to Editor.
Palomo T, RJ Beninger, RM Kostrzewa, T Archer (2007) Comorbidity implications in brain disease:
neuronal substrates of symptom profiles. Neurotoxicity Res. 12, 1-15.
Palomo T, RM Kostrzewa, RJ Beninger, T Archer (2007) Treatment consideration and manifest complexity
in comorbid neuropsychiatric disorders. Neurotoxicity Res. 12, 43-60.
Palomo T, RM Kostrzewa, RJ Beninger, T Archer (2007) Genetic variation and shared biological
susceptibility undrlying comorbidity in neuropsychiatry. Neurotoxicity Res. 12, 29-42.
Palomo T, T Archer, RM Kostrzewa, RJ Beninger (2007) Comorbidity of substance abuse with other
psychiatric disorders. Neurotoxicity Res. 12, 17-27.
Nowak P, M Swoboda, R Szkilnik, J Konecki, A Kwieciński, J Jośko, Ł Noras, K Sawczuk, RM
Kostrzewa, R Brus (2007) Nitric oxide (NO) modulates the amphetamine effect on [3H]glucose uptake in
the brain of rats prenatally exposed to lead. Pharmacol. Reports 59, 601-605.
Kostrzewa RM (2007) The blood-brain barrier for catecholamines – revisited. Neurotoxicity Res. 11, 261271.
Kostrzewa RM, J Segura-Aguilar (2007) Botulinum neurotoxin: evolution from poison, to research tool –
onto medicinal therapeutic and future pharmaceutical panacea. Neurotoxicity Res. 12, 275-290.
Kostrzewa RM, JP Kostrzewa, RA Kostrzewa, P Nowak, R Brus (2008) Pharmacological models of
ADHD. J. Neural Transm. 115, 287-298.
Kostrzewa RM (2008) Neurotoxins, In: New Encyclopedia of Neuroscience (Squire L, T Albright, F
Bloom, F Gage and N Spitzer, Eds.) (Elsevier:The Netherlands).
Bortel A, D Nitka, L Słomian, P Nowak, E Korossy, R Brus, RM Kostrzewa (2008) Neonatal noradrenergic
lesion with DSP-4 modifies the convulsant effect of bicuculine and pentylenetetrazole in adult rats.
Behavioral and biochemical studies. Ann. Acad. Med. Silesia 62(1), 46-52.
Bortel A, L Słomian, D Nitka, M Świerszcz, M Jaksz, P Nowak, RM Kostrzewa, R Brus (2008) Neonatal
DSP-4 treatment modifies the vulnerability to phenobarbital and ethanol evoked sedative-hypnotic effects in
adult rats. Pharmacol. Reports 60(3), 331-338.
Paris I, J Lozano, S Cardenas, C Periz-Pastene, K Saud, A Riveros, P Fuentes, P Caviedes, A DagninoSubiabre, R Raisman-Vozari, T Shimahara, JP Kostrzewa, D Chi, RM Kostrzewa, P Caviedes, J SeguraAguilar (2008) The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism.
Neurotoxicity Res. 13(3,4), 219-228.
Nowak P, G Szczerbak, D Nitka, RM Kostrzewa, R Brus (2008) Effect of prenatal lead exposure on
nigrostriatal neurotransmission and hydroxyl radical formation in rat neostriatum: Dopaminergic-nitrenergic
interaction. Toxicology 246, 83-89. Epub 2008 Jan 10.
Kostrzewa RM, JP Kostrzewa, R Brown, P Nowak, R Brus (2008) Dopamine receptor supersensitivity:
development, mechanisms, presentation, and clinical applicability. Neurotoxicity Res. 14, 121-128.
Nowak P, J Jochem, K Zwirska-Korczala, J Jośko, L Noras, RM Kostrzewa, R Brus (2008) Ontogenetic
noradrenergic lesion alters histaminergic activity in adult rats. Neurotoxicity Res. 13, 79- 83.
Nowak P, A Bortel, J Dąbrowska, I Biedka, G Słomian, W Roczniak, RM Kostrzewa, R Brus (2008)
Histamine H3 receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa-derived
extracellular dopamine in dopamine-denervated rat striatum. Neurotoxicity Res. 13 (3,4), 231-240.
Nowak P, G Szczerbak, D Nitka, RM Kostrzewa, J Jośko, R Brus (2008) Cortical dopaminergic
neurotransmission in rats intoxicated with lead during pregnancy. Nitric oxide and hydroxyl radicals
formation involvement. Neurotoxicol Teratol. 30, 428-432. E pub Mar 2008.
Palomo T, RJ Beninger, RM Kostrzewa, T Archer (2008) Focusing on symptoms rather than diagnoses in
brain dysfunction: conscious and nonconscious expression in impulsiveness and decision-making.
Neurotoxicity Res. 14(1), 1-20.
Palomo T, RM Kostrzewa, RJ Beninger, T Archer (2008) Schizopsychotic symptom-profiles and
biomarkers: beacons in diagnostic labyrinths. Neurotoxicity Res. 14(2,3), 79-96.
Palomo T, RJ Beninger, RM Kostrzewa, T Archer (2008) Affective status in relation to impulsive, motor
and motivational symptoms: personality, development and physical exercise. Neurotoxicity Res. 14(2,3),
151-168.
Archer T, RM Kostrzewa, RJ Beninger, T Palomo (2008) Cognitive symptoms facilitatory for diagnoses in
neuropsychiatric disorders: executive functions and locus of control. Neurotoxicity Res. 14(2,3), 205-225.
R.M. Kostrzewa, Ph.D.
191.
192.
193.
194.
195.
196.
197.
198.
199.
200.
201.
202.
203.
204.
205.
206.
207.
208.
209.
210.
211.
Nowak P, J Oświęcimska, E Korossy, J Drab, A Kwieciński, J Jośko, RM Kostrzewa, R Brus (2008)
Altered functional response of dopamine D3-like receptors in neonatally 6-OHDA-lesioned rats (rodent
model of Parkinson’s disease. Ann. Acad. Med. Silesia 62(3-4), 46-55.
Nowak P, Ł Noras, J Jochem, R Szkilnik, H Brus, E Korossy, J Drab, RM Kostrzewa, R Brus (2009)
Histaminergic activity in a rodent model of Parkinson’s disease. Neurotoxicity Res. 15(3), 246-251. doi:
10.1007/s12640-009-9025-1. Epub 2009 Feb 28.
Kostrzewa RM (2009) Evolution of neurotoxins: from research modalities to clinical realities, In Curent.
Protocols in Neuroscience, Wiley Interscience. Chapter 1:Unit1.18, pp. 1.18.1-1.18.10.
Kostrzewa RM, RA Kostrzewa, JP Kostrzewa (2009) Botulinum toxin for restoration of bladder control.
The Female Patient 34, 20-23.
Kostrzewa RM (2009) Editorial on ‘Neurotoxicity’. Neurotoxicity Res. 15(1), 1-2. DOI: 10.1007/s12640009-9029-x.
Nowak P, D Nitka, A Kwieciński, J Jośko, J Drab, D Pojda-Wilczek, J Kasperski, RM Kostrzewa, R Brus
(2009) Neonatal co-lesion by DSP-4 and 5,7-DHT produces adulthood behavioral sensitization to dopamine
D2 receptor agonists. Pharmacol. Rep. 61, 311-318.
Kostrzewa RM (2010) Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment, In: 5HT2C Receptors in the Pathophysiology of CNS Disease (Di Giovanni G, E Esposito, V Di Matteo, Eds.)
(Humana Press/Springer Science+Business Media, New York), pp. 383-393. ISBN: 978-1-60761-940-6.
DOI: 10.1007/9780-1-60761-941-3.
Nowak P, RA Kostrzewa, D Skaba, RM Kostrzewa (2010) Acute L-DOPA effect on hydroxyl radical- and
DOPAC-levels in striatal microdialysates of Parkinsonian rats. Neurotoxicity Res. 17(3), 299-304. DOI:
10.1007/s12640-009-9105-2. Epub, Sept. 4, 2009.
Archer T, RM Kostrzewa (2010) Staging neurological disorders: expressions of cognitive and motor
disorder. Neurotoxicity Res. 18(2), 107-111. DOI 10.1007/s12640-009-9134-x. [Editorial]
Archer T, RM Kostrzewa, T Palomo, RJ Beninger (2010) Clinical staging in the pathophysiology of
psychotic and affective disorders: facilitation of prognosis and treatment. Neurotoxicity Res. 18(3-4), 211228. Epub 2010 Mar 17.
Kostrzewa RM, L Antkiewicz-Michaluk, F Fornai (2010) Dopaminergic nerves as targets for neurotoxins,
In: Neurotoxicology, Target Organ Toxicity Series, 3rd Edition (Harry J, H Tilson, Eds.), Informa Health
Care, New York, pp. 112-137. [ISBN: 9781420054873]
Archer T, RM Kostrzewa, RJ Beninger, T Palomo (2010) Staging perspectives in neurodevelopmental
aspects of neuropsychiatry: agents, phases and ages at expression. Neurotoxicity Res. 18(3-4), 287-305.
Epub 2010 Mar 17.
Archer T, RJ Beninger, T Palomo, RM Kostrzewa (2010) Epigenetics and biomarkers in the staging of
neuropsychiatric disorders. Neurotoxicity Res. 18(3-4), 347-366. Epub 2010 Mar 17.
Ferdyn-Drosik M, P Nowak, K Bojanek, M Bałasz, J Kasperski, D Skaba, R Muchacki, RM Kostrzewa
(2010) Neonatal DSP-4 treatment impairs 5-HT1B receptor reactivity in adult rats. Behavioral and
biochemical studies. Pharmacol. Rep. 62(4), 608-20. PMID: 20885001.
Kostrzewa RM, JP Kostrzewa, RA Kostrzewa, FP Kostrzewa, R Brus, P Nowak (2011) Stereotypic
progressions in psychotic behavior. Neurotoxicity Res. 19, 243-252. DOI: 10.1007/s12640-010-9192-0
Nowak P, K Bojanek, R Szkilnik, J Jośko, D Boron, M Adwent, P Gorczyca, RM Kostrzewa, R Brus
(2011) Ontogenetic exposure of rats to pre- and postnatal manganese enhances behavioral impairments
produced by perinatal 6-hydroxydopamine. Neurotoxicity Res. 19(4), 536-543. Epub 2010 Apr 6. PMID:
20369314. DOI: 10.1007/s126.
Archer T, RM Kostrzewa, RJ Beninger, T Palomo (2011) Staging neurodegenerative disorders: structural,
regional, biomarker and functional progressions. Neurotoxicity Res. 19, 211-234.
Jośko J, J Drab, P Nowak R Szkilnik, E Kőrőssy, D Boroń, H Brus, RM Kostrzewa, R Brus (2011)
Thioperamide, an H3 receptor antagonist, prevents [3H]glucose uptake in adult rats lesioned as neonates
with 5,7-dihydroxytryptamine. Neurotoxicity Res. 20(1), 93-96. Epub 2010 Sep 14. PMID: 20838953
Jośko J, J Drab, J Jochem, P Nowak, R Szkilnik, E Kőrőssy-Mruk, D Boroń, RM Kostrzewa, H Brus, R
Brus (2011) Ontogenetic serotoninergic lesioning alters histaminergic activity in rats in adulthood.
Neurotoxicity Res. 20, 103-108. Epub 2010 Sep 14. PMID: 20838952. DOI: 10.1007/s12640-010-9217-8.
Archer T, A Fredriksson, E Szhulz, RM Kostrzewa (2011) Influence of physical exercise on
neuroimmunological functioning and health: aging and stress. Neurotoxicity Res. 20(1), 69-83. Epub 2010
Oct 15. DOI: 10.1007/s12640.010-9224-9. PMID: 20953749.
Brus R, J Jochem, P Nowak, M Adwent, D Boroń, H Brus, RM Kostrzewa (2012) Effect of pre- and
postnatal manganese exposure on brain histamine content in a rodent model of Parkinson’s disease.
Neurotoxicity Res. 21(2), 143-148. Epub 2011 Aug 6. PMID: 21822760.
R.M. Kostrzewa, Ph.D.
212. Archer T, RM Kostrzewa (2012) Physical exercise alleviates ADHD symptoms: regional deficits and
development trajectory. Neurotoxicity Res. 21(2), 195-209. Epub 2011 Aug 18. PMID: 21850535.
213. Kostrzewa RM, FP Kostrzewa (2012) Neonatal 6-hydroxydopamine lesioning enhances quinpirole-induced
214.
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218.
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vertical jumping in rats that were quinpirole-primed during postnatal ontogeny. Neurotoxicity Res.
21(2):231-235. Epub 2011 Aug 19. DOI: 10.1007/s12640-011-9268-5. PMID: 21853388.
Labus Ł, P Nowak, R Szkilnik, RM Kostrzewa, D Boroń, R Brus (2012) Neonatal DSP-4 lesioning of
central noradrenergic neurons: a model for the study of interaction with other neurotransmitter systems in
the brain of adult rats. Annales Acad. Med. Silesiensis.
Brown RW, AM Maple, MK Perna, AB Sheppard, ZA Cope, RM Kostrzewa (2012) Schizophrenia and
substance abuse comorbidity: Nicotine addiction and the neonatal quinpirole model. Dev Neurosci. 34(2-3),
140-151. Epub 2012 Jul 6. Review.
Korossy-Mruk E, K Kuter, P Nowak, R Szkilnik, RM Kostrzewa, R Brus (2013) Neonatal DSP-4 treatment
modifies analgesic effect of methanandamide, a CB1 receptor agonist in adult rats. Neurotoxicity Res. 23(1),
39-48.
Archer T, RM Kostrzewa (2013) The inductive agency of stress: from perinatal to adolescent induction, In
Adaptive and Maladaptive Aspects of Developmental Stress, (Laviola G, S Macri, Eds.),. Springer New
York, pp. 1-20.
Nowak P, M Kowalińska-Kania, D Nowak, RM Kostrzewa, J Malinowska-Borowska (2013)
Antinociceptive effects of H3 (R-methylhistamine) and GABAB (baclofen) -receptor ligands in an orofacial
model of pain in rats. Neurotoxicity Res. 24, 258-264. Epub 2013 Mar 6. Doi: 10.1007/s12640-013-9385-4.
PMID: 23463522.
Kostrzewa RM, JP Kostrzewa, R Brus (2014) Tardive dyskinesia: Outcome of antipsychotic treatment and
brain damage?, in Section on Diseases and Disorders Relevant to Neurotoxins, in Handbook of
Neurotoxicity (Kostrzewa RM, Editor), Springer New York, pp. 2315-2326. ISBN 978-1-4614-5835-7
(print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI
10.1007/978-1-4614-5836-4_163.
Kostrzewa RM (2014) Survey of Selective Neurotoxins (chapter title), in Section on Selective Neurotoxins, in
Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, Heidelberg, Dordrecht, London,
2014, pp. 3-67. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-74586 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4_53.
Archer T, S Ricci, M Rapp-Ricciardi, RM Kostrzewa (2014) Polluting agents in Parkinsonism: I Transition
metals, in Section on Neurotoxicity in Psychiatric and Neurologic Disorders, in Handbook of Neurotoxicity
(Kostrzewa RM, Editor), Springer New York, pp. 2315-2326. ISBN 978-1-4614-5835-7 (print); ISBN 9781-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle).
Chen J, RM Kostrzewa, X Xu (2014) Necroptosis, a potential therapeutic target for neurological disorders”,
in Section on Selective Neurotoxins (RM Kostrzewa, Section Editor), in Handbook of Neurotoxicity
(Kostrzewa RM, Editor), Springer New York, pp. 2315-2326. ISBN 978-1-4614-5835-7 (print); ISBN 9781-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-46145836-4_166.
Szkilnik R, R Brus, J Malinowska-Borowska, D Nowak, M Waliczek, RM Kostrzewa, P Nowak (2014)
Ontogenetic manganese exposure with perinatal 6-OHDA lesioning alters behavioral responses of rats to
dopamine D1 and D2 agonist treatments. Environ. Toxicol. Pharmacol. 37, 28-36.
Chandley MJ, A Szebeni, K Szebeni, JD Crawford, CA Stockmeier, G Turecki, RM Kostrzewa, GA
Ordway (2014) Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus
coeruleus in major depression. Int. J. Neuropsychopharmacol. pp 1-10. doi:10.1017/S1461145714000662
Bałasz M, R Szkilnik, R Brus, J Malinowska-Borowska, D Nowak, RM Kostrzewa, P Nowak (2015)
Perinatal manganese exposure and hydroxyl radical formation in rat brain. Neurotoxicity Res. 27, 1-14.
(accepted, May 2014)
Archer T, D Garcia, RM Kostrzewa (2015?) Exercise and dietary restriction for promotion of neurohealth
benefits. Neurotoxicity Res. (submitted Jun 2014)
Danysz W, G Fink, A McCreary, C Tober, W Dimpfel, JC Bizot, RM Kostrzewa, RW Brown, CC Jatzke, S
Greco, AK Jensen, CG Parsons (2015) Effects of sarizotan in animal models of ADHD – challenging
pharmacokinetic-pharmacodynamic relationships. J. Neural Transm. (accepted March 2015) DOI
10.1007/s00702-015-1392-6
Sadakierska-Chudy A, RM Kostrzewa, M Filip (2015) A comprehensive view of the epigenetic landscape.
Part I. DNA methylation, passive and active DNA demethylation pathways and histone variants.
Neurotoxicity Res. 27, 84-97.
R.M. Kostrzewa, Ph.D.
229.
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Segura-Aguilar J, RM Kostrzewa (2015) Neurotoxin mechanisms and processes relevant to Parkinson´s
Disease. An update. Neurotoxicity Res. 27, 328-354.
Archer T, RM Kostrzewa (2015?) Physical exercise alleviates health defects, symptoms and biomarkers in
schizophrenia spectrum disorders. Review. (revised Feb 6, 2015)
Li X, Zhao H, Tan X, Kostrzewa RM, Du G, Chen Y, Zhu J, Miao Z, Yu H, Kong J, Xu X (May 2015)
Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats. Glia
2015 May 19. doi: 10.1002/glia.22826. [Epub ahead of print]
Kostrzewa RM, RA Kostrzewa, JP Kostrzewa (2015?) Botulinum neurotoxin: progress in negating its
neurotoxicity; and in extending its therapeutic utility via molecular engineering. MiniReview. (submitted
March 2015).
BOOKS
Kostrzewa RM (Author) Pharmacology, Blond’s Medical Guides, 398 pages, Sulzburger & Graham Publishers,
New York, N.Y. 1996. ISBN 0-945819-48-X
Kostrzewa RM (Editor) Highly Selective Neurotoxins: Basic and Clinical Applications, 404 pages, The Humana
Press, Totowa, N.J., 1998. ISBN 0-89603-465-8
Beninger RJ, T Palomo, RM Kostrzewa and T Archer (co-Editors), 762 pages, Neurodevelopmental
Liabilities in Brain Disease States, 762 pages, Fundación Cerebro y Mente, Madrid, Spain, 2003. ISBN 84921848-9-2
Palomo T, RJ Beninger, RM Kostrzewa and T Archer (co-Editors) Gene-Environment I-nterplay in Brain Disease
States, 575 pages, Fundación Cerebro y Mente, Madrid, Spain, 2005. ISBN 84-934250-1-X
Palomo T, RJ Beninger, RM Kostrzewa and T Archer (co-Editors), 698 pages, Implications of Comorbidity for
Etiology and Treatment of Neuropsychistric Disorders, Fundación Cerebro y Mente, Madrid, Spain, 2007.
ISBN 978-84-934250-0-5
Palomo T, RJ Beninger, RM Kostrzewa and T Archer (co-Editors), 708 pages, Beyond Neuropsychiatric
Diagnostics: Symptoms not Disorders, Fundación Cerebro y Mente, Madrid, Spain, 2009. ISBN 978-84934250-4-3
Palomo T, RM Kostrzewa and RJ Beninger (co-Editors), 433 pages, Staging Neuropsychiatric Disorders:
Implications for Etiopathogenesis and Treatment, Fundación Cerebro y Mente, Madrid, Spain, 2013. ISBN
978-1-4614-7263-6
Kostrzewa RM (Editor-in-Chief) Handbook of Neurotoxicity, Springer New York, Heidelberg, Dordrecht, London,
June 2014. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6
(print and electronic bundle). DOI 10.1007/978-1-4614-5836-4
Archer T, MR Riciardi, RM Kostrzewa (co-Editors) Environmental and Lifestyle Stress Neurotoxicity, for
Kostrzewa RM & T Archer Neurotoxicity book series, Springer New York, October 2015 (target completion
date).
Kostrzewa RM, T Archer (co-Editors) Neurotoxin Modeling of Brain Disorders – Life-long Outcomes in Behavioral
Teratology (working title), for Current Topics in Behavioral Neuroscience (CTBN) book series (Geyer M, C
Marsden, B Ellenbroek, Editors) (Springer New York). December 2015 (target completion)