Rajesh Agarwal, Ph.D.
CURRICULUM VITAE
Rajesh Agarwal, Ph.D.
Office address:
Department of Pharmaceutical Sciences
School of Pharmacy
University of Colorado Health Sciences Center
4200 East Ninth Street, Box C238
Denver, CO 80262
Office telephone number:
(303) 315-1381
Office Fax number:
(303) 315-6281
E-mail:
Rajesh.Agarwal@UCHSC.edu
Education
1975
1976
1977
1981
B.Sc.: Chemistry, Botany, and Zoology - Lucknow University, India.
B.Sc. (Hons.): Organic Chemistry - Lucknow University, India.
M.Sc.: Organic Chemistry - Lucknow University, India.
Ph.D.: Bioorganic Chemistry (Medicinal) - Lucknow University, India.
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Rajesh Agarwal, Ph.D.
Academic Appointments
3/2001-
Professor (7/04: Tenure), Department of Pharmaceutical Sciences,
School of Pharmacy, University of Colorado Health Sciences Center,
Denver, Colorado.
7/2001-
Graduate Faculty, Toxicology/Pharmaceutical Sciences, Department of
Pharmaceutical Sciences, School of Pharmacy, University of Colorado
Health Sciences Center, Denver, Colorado.
1998-
Full Member, University of Colorado Cancer Center, University of
Colorado Health Sciences Center, Denver, Colorado.
2000-2001
Senior Scientist (Professor), Center for Cancer Causation and Prevention,
AMC Cancer Research Center, Denver, Colorado.
1998-2000
Scientist (Associate Professor), Center for Cancer Causation and
Prevention, AMC Cancer Research Center, Denver, Colorado.
1992-1997
Assistant Professor, Department of Dermatology, Case Western Reserve
University, Cleveland, Ohio.
1995-1997
Assistant Professor, Division of General Medical Sciences (Oncology) and
CWRU Cancer Center, Case Western Reserve University, Cleveland,
Ohio.
1991-1992
Senior Research Associate, Department of Dermatology, Case Western
Reserve University, Cleveland, Ohio.
1989-1991
Research Associate, Department of Dermatology, Case Western Reserve
University, Cleveland, Ohio.
1988-1989
Research Associate, Department of Pathology/Department of Biology,
Case Western Reserve University, Cleveland, Ohio.
1985-1988
Assistant Professor, Chemistry Department, Manipur University, Imphal,
India.
1983-1985
Research Associate/Scientist Pool, Industrial Toxicology Research
Center, Lucknow, India.
1978-1982
Junior/Senior/Post-Doctoral Research Fellow, Chemistry Department,
Lucknow University, Lucknow, India.
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Rajesh Agarwal, Ph.D.
Professional Experience
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Prevention of cancer: Dietary and synthetic agents - cellular, biochemical and
molecular mechanisms employing biochemical and molecular biological techniques.
Evaluation of cancer chemopreventive potential of dietary constituents employing
several long-term animal tumor bioassay protocols, and short-term animal and cell
culture assays. Models include skin, prostate, breast, lung, colon, bladder.
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Mechanism of cancer prevention: Oncogenes and suppressor genes - ras
oncoprotein p21 processing enzyme farnesyltransferase, cell cycle modulation, p53,
cyclins, cyclin dependent kinases, cyclin dependent kinase inhibitors (Cip 1/p21,
Kip1/p27), apoptosis, and mitogenic and anti-apoptotic signaling pathways.
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Therapy of cancer: Dietary and synthetic agents - cell culture studies and nude mice
xenograft models.
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Carcinogenesis - causation and mechanistic studies employing enzyme bioassay
and molecular biology approaches, cell culture technique and long-term animal
tumor studies.
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Drug Metabolism - purification of cytochrome P450 1A1, and characterization by
SDS-PAGE, Western blotting, peptide mapping and sequencing.
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Photodynamic therapy -in vivo and in vitro mechanisms of photodynamic effect of
photosensitizers, specifically phthalocyanines, and evaluation of PDT effect of
phthalocyanines in murine skin tumor models.
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Protein chemistry - isolation, characterization and structure determination of proteins
by chemical modifications, photo cross-linking, HPLC, SDS-PAGE analysis,
Western blotting, peptide analysis and N-terminal amino acid sequencing.
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Medicinal chemistry - synthesis of different heterocyclic nuclei like indoles,
quinazolones, imidazolones, pyrazolones, thiazolidenes etc., their structural
characterization and screening for CNS disorders and activity as anti-inflammatory
agents. Isolation and characterization of phytochemicals as potential cancer
preventive agents.
Consulting Activity
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Consultant with Indena, Italy, on developing silibinin for prostate cancer
prevention and treatment in the patients, 2003.
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Rajesh Agarwal, Ph.D.
Teaching Activity
1.
Undergraduate and Graduate Courses
Pharm D Courses at SOP, UCHSC:
Fall, 2001-2004
IOS X, PHRD 5710, Pharmacology of Antimicrobial
agents (P3).
Fall, 2001
Instructional Methods II, PHRD 4200 (P1).
Spring, 2002-2005
IOS I, PHRD 3750, Endocrine System (P1).
Fall, 2002-2005
IOS IX, PHRD 5700, Endocrine Systems – Hormone
Regulation Review (P3), Co-instructor with Dr. Altiere.
Spring, 2003-2005
PHRD 5860, Alternative Medicine Course.
Spring, 2002-Present:
IOS VI, PHRD 4750, Cancer Chemotherapy (P2).
Graduate Courses at DOPS, SOP, UCHSC:
Fall, 2002-2004
Course Coordinator, Topics in Toxicology Research.
Fall, 2002-2005
Instructor, Experimental Methods in Toxicology.
Spring, 2003
Instructor, Pharmacology Course/Natural Products
and Chemoprevention.
Spring, 2005
Instructor, TXCL-PHSC 7530 Cancer: Experimental
and Medical Aspects, Cancer Chemoprevention.
Spring, 2002-2006
Instructor, Principles of Toxicology II: Drug
Metabolism - Sulfate Conjugation & Acylation.
Spring, 2006
Course Co-Director, Environmental and Target Organ
Toxicology, TXCL 7323
Fall, 2006
Course Director and Instructor, TXCL-PHSC 7400
Ethical Issues in Tox & Pharm Sci.
Spring, 2002-Present:
Instructor, Principles of Toxicology II: Heart &
Vascular.
Fall, 2005-Present
Instructor, Principles of Toxicology I, Cancer
Chemoprotection.
Fall, 2005-Present:
Instructor, Principles of Toxicology I, Signal
Transduction.
Winter, 2005-Present
Instructor, TXCL-PHSC 7400 Ethical Issues in Tox &
Pharm Sci.
2.
Continuing Education
Lectures and Seminars to Residents at Department of Dermatology, Case
Western Reserve University, Clevelend, OH. 1993-1997. The format included:
Journal Club, Lectures related to molecular biology and other laboratory
techniques, and Laboratory Methods demonstration.
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Rajesh Agarwal, Ph.D.
Advising Activity
Pharm D.
Advisor to Todd Allen and Julie Ball, P3 students, for their seminar presentation on
Complementary and Alternative Therapies for Cancer Treatment, December 2002.
Advisor to Ylan Cao and Kiesha Van Valkenburgh, P3 students, for their seminar
presentation on Epidermal Growth Factor Receptor: A molecular target for epithelial
cancer prevention and therapy, April, 2004.
Advisor to Vanessa Rogers and Jennifer Trask, P3 students, for their seminar
presentation on Nutritional supplements: good or bad for cancer patients, November,
2006.
Advisor to Ajay Gupta and Galina B Yermilova, P3 students, for their seminar
presentation on Nutritional supplements: good or bad for cancer patients, September,
2007.
Ph.D. Students
Srirupa Roy, Molecular Toxicology Graduate Program, DOPS (2003-).
Samiha M. Mateen, Molecular Toxicology Graduate Program, DOPS (2007-).
Graduate Students Rotations – UCHSC, DOPS
Kathryn Zolman (2001)
Jessica Krank (2002)
Marta Narvaez (2002)
Heather Walczak (2002)
Srirupa Roy (2002)
Heather Leitner (2003)
Samiha M. Mateen (2007)
Sangeeta Shrotriya (2007)
Graduate Students Committees – UCHSC, DOPS
Member on Charles Hughes (M.S. Defense Committee, graduated 2002)
Member on Jeanmarie Zodrow (graduated 2003)
Member on Katherine Peebles (graduated 2005)
Member on Mark Reimers (2001-2005, graduated 2005)
Chair on David Carbone (2001-2005, graduated 2005)
Chair on Brante Sampey (2001-2005, graduated 2005)
Chair on Ileana Vargas (2001-2005, graduated with Masters, 2005)
Member on Heather Walczak (2002-2007, graduated 2007)
Member on Elizabeth Redente (2003-)
Chair on James R. Roede (2006-)
Chair on Jason Fritz (2007-)
Member on Yan Chao (2007-)
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Rajesh Agarwal, Ph.D.
Undergraduate Students
Name
Galvin, Brea
Title of Research Project
Phytochemicals and skin cancer.
Training Period
2003
Haque, A.
Search for potential cancer chemopreventive agents.
1993-1995
Julka, K.
Epidermal growth factor receptor
and cancer prevention by silymarin.
1996
Kale, S.
Phytochemicals and Prostate Cancer
Prevention.
2000
Kapoor, Ruchi
Phytochemicals and prostate cancer.
2003
Krishnamurthi, R.
Evaluation of antioxidant potential
of silymarin.
1994-1995
Liem, V.K.
Ha-Ras oncogene and skin cancer.
1993
Sathi, Kunji
Phytochemicals and prostate cancer.
2003
Sequeira, Sabina
Flavonoids and bladder cancer.
2003
Sharma, Kapil
Phytochemicals and Prostate cancer
2001
Sinha, Arjun
Prostate cancer therapeutic agents.
2006
Postdoctoral Fellows/ Faculties
Name
Ahmad, N., Ph.D.
Title of Research Project
Cell cycle control and apoptosis
in skin cancer therapy.
Training Period Current Position
1996 to 1998 Associate Prof.,
Univ of Madison
Balaiya, Vel, Ph.D.
CRC and Phytochemicals
2007-
Post-doc (current)
Bhatia, N., Ph.D.
Signal transduction, cell cycle
regulation and prostate cancer.
1998-2000
Post-doc
Broussard, Alton
Laboratory Manager
2005-
PRA (current)
Chittezhath, M, Ph.D.
Silibinin and epithelial cancer prevention. 2004-2005
Res. Assoc., Emory
Deep, Gagan, Ph.D.
Flavolignan and cancer prevention.
2004-
Res. Assoc. (current)
Dhanalakshmi, S., Ph.D. Cancer Prevention via targetting cell
survival signaling.
2000-2004
Res. Scientist, Biotech,
India.
Flaig, Thomas, M.D.
Silibinin and prostate cancer
2005-
Assistant Professor
Oncology Div, UCDHSC
Gali, H., Ph.D.
Epidermal growth factor receptor
and cancer prevention by silymarin.
1996
Professor, Lebanon
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Rajesh Agarwal, Ph.D.
Javed, S., Ph.D.
Mechanism of skin chemical
carcinogenesis.
Katiyar, S.K., Ph.D.
Skin cancer chemoprevention:
1992-1995
mechanism and long-term tumor studies.
Associate Prof,
Univ of Alabama
Kaul, Nidhi, M.D.
GSE and cancer prevention.
2006-2007
Internal Medicine
Residency, NY
Kaur, M., Ph.D.
Silibinin and lung cancer prevention.
2003-
Res. Assoc. (current)
Khan, S.G., Ph.D.
Ras oncogene, farnesyltransferase
and skin carcinogenesis.
1992-1995
Tenured Scientist,
NCI/NIH, Intramural
Kuhn, C., M.D.
Metabolism of chemical carcinogens
in mouse and human epidermal cells.
1992-1993
Private Practice,
Dermatology, USA
Lahiri, M., Ph.D.
Photocarcinogenesis and skin cancer
Chemoprevention.
1995-1996
Biotech Sales Rep,
India
2002-
Res. Assoc. (current)
Mallikarjuna, GU, Ph.D. Skin cancer prevention by silibinin.
1993, 1996
Science Writer, India
Mohan, R.R., Ph.D.
Ras p21 processing, retinoids and skin 1993-1995
tumor progression.
Associate Prof,
Univ. of MO
Mohan, S., Ph.D.
Silibinin and skin cancer prevention.
2003-2005
Post-doc, Univ South
Carolina
Pal, Arttatrana, Ph.D.
CEES toxicity and Rescue
2007-
Res. Assoc. (current)
Rajamanickam, S., Ph.D. CRC and Phytochemicals
2007-
Post-doc (current)
Raina, Komal, Ph.D.
Silibinin efficacy in epithelial cancer.
2005-
Post-doc (current)
Ramasamy, K., Ph.D.
Silibinin and lung cancer
2007-
Post-doc (current)
Rana, Sumeet, M.Phil. CEES toxicity and Rescue
2006
PRA (current)
Sharma, Girish, Ph.D.
Grape seed extract and breast cancer.
2001-2003
Assistant Prof. Res.,
Univ. of SC
Sharma, Y., Ph.D.
Mechanism of silymarin’s anti1998-2000,
carcinogenic activity in prostate cancer. 2007
Professor,
Lucknow Univ., India
Singh, Rana P., Ph.D.
Skin cancer prevention by silibinin.
2000-2006
Associate Prof., JNU
New Delhi, India
Tewari-Singh, N., Ph.D. CEES toxicity and Rescue
2006-
Res. Assoc. (current)
Tyagi, Alpana, Ph.D.
Phytic acid and prostate cancer: role
of receptor endocytosis.
1999-
Res. Assoc. (current)
Tyagi, Anil, Ph.D.
Phytochemicals and Cancer Prevention: 2000-2004
Identification of active compounds.
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Res. Assoc., UCHSC
Rajesh Agarwal, Ph.D.
Varghese, Leyon, Ph.D. Phytoprevention of angiogenesis.
2004-2005
Res. Assoc., Singapore
University
Zhao, J., Ph.D.
Phytochemicals and skin cancer
Prevention.
1998-2000
Scientist, Biotech Co.
Zi, X., MD, Ph.D.
Signal transduction & cell cycle
regulation in cancer prevention.
1996 to 1998
Assistant Prof.,
Univ of California, Irwin
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Rajesh Agarwal, Ph.D.
Administrative Activity and University Service
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Member, Core Curriculum Committee, Department of Dermatology, CWRU,
1994-1997.
Member, Academic Computer Committee, Department of Dermatology, CWRU,
1996-1998.
Chair, Budget Sub-committee for Academic Computer Committee, Department
of Dermatology, CWRU, 1996-1998.
Member, Safety Committee, AMC Cancer Center, Denver, CO, 1998-1999.
Member, Biohazard Committee, AMC Cancer Center, Denver, CO, 1999-2000.
Member, ASPA Committee, AMC Cancer Research Center, Denver, CO, 20002001.
Chair, Sunscreen Certification Committee of ASPA, AMC Cancer Research
Center, Denver, CO, 2000-2001.
At UCHSC
 Member, Toxicology Graduate Program Admission Committee, DOPS, SOP,
2001 Member, Space Committee, SOP, 2002-2004.
 Member, Search Committee, Basic Science/Prostate Cancer Faculty Candidate,
Univ. Colorado Cancer Center, UCHSC, 2002.
 Chair, Student Admission and Affairs Sub-committee, Toxicology Graduate
Program, DOPS, SOP, 2002 Member, Curriculum Sub-committee, Toxicology Graduate Program, DOPS,
SOP, 2002.
 Co-Organizer, Seminar Series for Toxicology Graduate Program, DOPS, 20022003.
 Co-Organizer, Journal Club for Toxicology Graduate Program, DOPS, 20022003.
 Organizer, Seminar Series for Toxicology Graduate Program, DOPS, 2003-2004.
 Organizer, Journal Club for Toxicology Graduate Program, DOPS, 2003-2004.
 Member, Post-doctoral Task Force, UCHSC, represented SOP, DOPS, 2003.
 Member, Molecular Toxicology Faculty Search Committee, DOPS, SOP, 20022003.
 Member, DOPS Research Committee, 2003 Member, DOPS Appointment, Promotion and Tenure Committee, 2004-2006;
2006-2008.
 Chair, DOPS Appointment, Promotion and Tenure Committee, 2005-2006.
 Member, Building Committee, Pharmaceutical Research Center of the Skaggs
School of Pharmacy and Pharmaceutical Sciences, 2007 Chair, Search Committee for PK/PD Faculty Position, DOPS, SOP, UCHSC,
2007.
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Rajesh Agarwal, Ph.D.
Professional Activity and Public Service
Membership in Professional Organizations
 Member, American Association for Cancer Research.
 Member, American Association for the Advancement of Science.
 Member, American Society for Photobiology.
 Member, Society for Investigative Dermatology, USA (upto 2000).
Grant Review Panels
 Research Advisory Group Proposals from Veterans Administration, Washington
DC, 1994-1995.
 Merit Review Proposals from Veterans Administration, Washington DC, 19941995.
 Member, Special Emphasis Panel on Cancer Chemoprevention, National Cancer
Institute, NIH, Bethesda, MD, 1997-1998.
 Member, NIH/NCRR Site Visit Team to the Florida International University Res.
Ctr. in Minority Inst Program, March, 1999.
 Ad-hoc Member, Metabolic Pathology Study Section, NCI, NIH, March 13-15,
2000.
 Ad-hoc Member, Metabolic Pathology Study Section, NCI, NIH, June 26-28,
2000.
 Member, NCI/NIH Site Visit Team for Program Project on “Inhibition of
Carcinogenesis by Tea and Tea Constituents”, Rutgers University, May 17-19,
2000.
 Chairman, NCI/NIH Special Emphasis Panel, ZRG1 CONC (02)M, July 19, 2000.
 Member, NCI/NIH Special Emphasis Panel, ZRG1 ET-2 03, December 12, 2000.
 Member, NCI/NIH Teleconference Review Panel for Program Project on
“Inhibition of Carcinogenesis by Tea and Tea Constituents”, Rutgers University,
January 11, 2001.
 Ad-hoc Member, Chemical Pathology Study Section, NCI, NIH, January 17-19,
2001.
 Ad-hoc Member, Chemical Pathology Study Section, NCI, NIH, June 11-13,
2001.
 Ad-hoc Member, Subcommittee-Cancer Epidemiology, Prevention and Control
Study Section, NCI, NIH, April 4-6, 2001.
 Member, California Breast Cancer Research Program (Innovative Treatments)
Review Committee, CA, April 20-21, 2001.
 Member (mail reviewer), Ohio Cancer Research Associates Grant Review,
Columbus, OH, May-June, 2001.
 Member (mail reviewer), Special Emphasis Panel, Evaluation of
Chemopreventive Agents by In Vivo Screening, NCI, NIH, June, 2001.
 Member, NIEHS Special Emphasis Panel, ZES1 BKW-C (RO), NIH, July 15-18,
2001.
 Member/Reviewer (by Mail), Biomedical Research Council, Singapore, July
2001.
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Rajesh Agarwal, Ph.D.
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Member, NCI Special Emphasis Panel, ZRG1 CPA-02, October 11, 2001.
Member, NCI Special Review Committee Meeting, ZRG1 PTHB 01 M, November
7, 2001.
Member, California Breast Cancer Research Program (Innovative Treatments)
Review Committee, CA, April 27-29, 2002
Special Reviewer (by mail), U.S. Civilian Research and Development
Foundation, June 2002.
Member/Reviewer (by Mail), Biomedical Research Council, Singapore, July
2002.
Member, NCI Special Emphasis Panel, ZCA1 SRRB-Q (J1) Cooperative Grants
for Nutritional Modulation of Genetic Pathways Leading to Cancer, November 68, 2002.
Member, California Breast Cancer Research Program (Innovative Treatments)
Review Committee, CA, March 29-31, 2003.
Ad-hoc Member, Subcommittee-Cancer Epidemiology, Prevention and Control
Study Section, NCI, NIH, July 29-30, 2003.
Member, NCI/NIH Teleconference Review Panel for Supplement to Program
Project on “Inhibition of Carcinogenesis by Tea and Tea Constituents”, Rutgers
University, February 18, 2004.
Member, NCI Special Emphasis Panel ZCA1 SRRB-Y (M1), Developmental/Pilot
Projects in Cancer Complementary and Alternative Medicine, March 8-10, 2004.
Member, European Science Foundation Exploratory Workshop Review Pannel,
France, 2004.
Reviewer, Pilot Project Program, Center for Research on Environmental
Disease, UT MD Anderson Cancer Center, Science Park Division, Texas, 2004.
Reviewer, Biomedical Research Council Research Proposals, Singapore, 2004.
Member, NCI Special Review Committee Meetings (teleconference reviews),
3/11/2002, 6/28/2002, 7/18/2002, 11/14/2002, 11/19/2002, 4/1/2003, 7/9/2003,
7/24/2003, 11/17/2003, 4/7/2004, 4/12/2005, 7/26/2005, 11/1/2005, 5/25/2006,
10/30/06.
Regular Member, Cancer Etiology (formerly Chemical Pathology) Study
Section, NCI, NIH, October, 2001 to June, 2005.
Member, Review Panel RFA-A1-04-045, Centers for Countermeasaures against
Radiation, ZCA1 SRRB-E (01), June 20-22, 2005.
Mail Reviewer, University of Kansas, Center for Cancer Experimental
Therapeutics, Center of Biomedical Research Excellence (COBRE), NIH, grant
review, September, 2005.
Mail Reviewer, Research Management Group, Philip Morris External Research
Program, November, 2005.
Ad-hoc Member, Cancer Etiology Study Section, NCI, NIH, February 13-15,
2006; June 19-20, 2006; October 16-17, 2006; February 12-13, 2007; June
11-12, 2007.
Member, California Breast Cancer Research Program (Innovative Treatments)
Review Committee, CA, March, 2006, 2007.
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Rajesh Agarwal, Ph.D.
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Member of the Review Committee Site Visit Team, NCI, IRG Subcommittee A
(Cancer Centers P30 Program), Moffitt Cancer Center, University of South
Florida, Tempa, FL. June12-14, 2006.
Member, Peer Review Panel, DOD-Prostate Cancer Research Program,
Exploration: Hypothesis Development #3, May-june, 2006.
Member, Teleconference Peer Review Panel, University of Connecticut, Center
for Health, Intervention and Prevention Seed Grants Program, August 4 th, 2006.
Member, American Institute for Cancer Research (Panel 1, Prevention
Research) Review Committee, Washington DC, March, 2007; August, 2007.
Member, NCCAM SEP ZAT1 SM-07 Review Committee for Centers of
Excellence for Research on Complementary and Alternative Medicine (CERC),
Bethesda, MD, June 20th to 22nd, 2007.
Member On-site Visit Team, Austria Government Cancer Center Program,
Vienna, Austria, September 20th, 2007.
Mail Reviewer, French National Cancer Institute Grant Review Panel, September
17, 2007.
Ad-hoc Member, Chemo and Dietary Prevention Study Section, NCI, NIH,
October 4-5, 2007.
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Rajesh Agarwal, Ph.D.
Journal Referee
 AAPS Journal
 Acta Pharmacologica Sinica
 Antioxidant and Redox Signaling
 Biochemical Pharmacology
 Biochimie
 Brain Research
 Breast Cancer Research
 Cancer Causes and Control
 Cancer Epidemiology, Biomarkers and Prevention
 Cancer Letters
 Cancer Research
 Carcinogenesis
 Cell Biology and Toxicology
 Chemico-Biological Interactions
 Clinical Cancer Research
 Comparative Biochemistry and Physiology
 Current Medicinal Chemistry
 European Journal of Cancer
 European J. of Cell Biology
 Experimental Biology and Medicine
 Expert Review of Anticancer Therapy-Future Drugs
 FEBS Letters
 Food and Chemical Toxicology
 Free Radical Biology and Medicine
 Gastroenterology
 International Journal of Cancer
 International Journal of Oncology
 International Journal of Radiation Biology
 Journal of Biological Chemistry
 Journal of Cellular Physiology
 Journal of Dental Research
 Journal of Dermatological Science
 Journal of the National Cancer Institute
 Journal of Pharmaceutical Sciences
 Kidney International
 Life Sciences
 Lipids
 Medical Research Reviews
 Molecular Cancer Research
 Molecular Cancer Therapeutics
 Molecular Carcinogenesis
 Molecular Nutrition and Food Research
 Molecular Pharmacology
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Rajesh Agarwal, Ph.D.
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Mutation Research
Neoplasia
Nucleic Acids Research
Nutrition and Cancer
Oncogene
Pharmaceutical Research
Photochemistry and Photobiology
PNAS, USA
Proceeding Indian National Science Academy
Skin Pharmacology
The International Journal of Biochemistry
The Journal of Investigative Dermatology
Toxicology and Applied Pharmacology
Toxicology Letters
Trends in Pharmacological Sciences
Urology
Editorial Board
Member, Editorial Board of Skin Pharmacology, 1995-2000.
Member, Editorial Board, Molecular Cancer Therapeutics, 2005Member, NCI PDQ Complementary and Alternative Medicine in Cancer Treatment
(CAM) Editorial Advisory Board, 2005Member, Editorial Board, Clinical Medicine: Oncology, 2007Member, Editorial Board, International Journal in Medical Engineering and Informatics,
2007Member, Editorial Board, Clinical Medicine: Urology, 2007Member, Editorial Board, Clinical Medicine: Dermatology, 2007-
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Rajesh Agarwal, Ph.D.
Invited Speaker, Honors and Awards
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Invited talk entitled “Silibinin and Angioprevention – an upcoming strategy” at the 2nd
International Symposium on Translational Research on Natural Products and
Cancer. Lonavala, Mumbai, India, December 9-12, 2007.
Key Note Address entitled “Chemoprevention of Prostate Cancer by Silibinin: Bench
to Bedside” at 18th All India Congress of Zoology and SCIAZE, University of
Lucknow, Lucknow, India, December 7-9, 2007.
Invited talk entitled “Lung cancer chemoprevention by silibinin” at the 9 th
International Conference on Mechanisms of Antimutagenesis and
Anticarcinogenesis. Jeju Island, S. Korea, December 1-5, 2007.
Invited talk entitled “Prostate Cancer chemoprevention by silibinin: bench to
bedside” at Department of Pathology, UCDHSC, Aurora, CO, October 26 th, 2007.
Co-chaired session entitled “Alternative Medicine and Cancer Chemoprevention” at
12th World Congress on Advances in Oncology and 10th International Symposium on
Molecular Medicine: Bioactive Food Components, Alternative Medicine and Cancer
Chemoprevention: Recent Advances. Crete, Greece, October, 2007.
Invited talk entitled “Recent advances in mechanism of cancer chemoprevention by
grape seed extract” at 12th World Congress on Advances in Oncology and 10th
International Symposium on Molecular Medicine: Bioactive Food Components,
Alternative Medicine and Cancer Chemoprevention: Recent Advances. Crete,
Greece, October, 2007.
Invited talk entitled “Dietary Supplement Milk Thistle Extract and Prostate Cancer:
Mechanisms and Efficacy” at the Monthly Lecture Series of the Office of Cancer
Complementary and Alternative Medicine, NCI, NIH, Bethesda, MD, May 9 th, 2007.
Shell Award Lecture entitled “Silibinin Efficacy in Cancer Models – An Update”, at
Shell Prize Symposium on Cancer Chemo-Prevention, School of Pharmacy,
UCDHSC, Denver, CO, March 30th, 2007.
Organizer of the Shell Prize Symposium on Cancer Chemo-Prevention, School of
Pharmacy, UCDHSC, Denver, CO, March 30th, 2007.
Invited talk entitled “Molecular mechanism of prostate cancer prevention by a dietary
nutrient inositol hexaphosphate” at Natural Products, Diets and Cancer Prevention
Session of the American Chemical Society National Meeting, Chicago, IL. March
25th, 2007.
Invited talk entitled “Prostate cancer prevention by flavonoid silibinin” at 4th
Bio/Molecular Informatics Center International Symposium entitled “Flavonoids: old
subjects but new challenges” held at Konkuk University, Seoul, Korea; February 7,
2007.
Invited talk entitled “Prostate cancer prevention by silibinin: mechanisms and
efficacy” at University of Connecticut Health Sciences Center, Center for Molecular
Medicine, January 24th, 2007.
Invited talk entitled “Chemoprevention of prostate cancer by silibinin” at UC Davis,
December 7th, 2006.
Invited talk entitled “Prostate cancer prevention by silibinin” at The International
Radiation Oncology Conference Special Session on Cancer Chemoprevention,
Varanasi, India, November 20-22, 2006.
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Rajesh Agarwal, Ph.D.
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Invited talk entitled “Molecular mechanism of prostate cancer prevention by a dietary
nutrient inositol hexaphosphate” at The 3 rd APOCP Conference “Empowering
Cancer Prevention in the Asian Pacific”, Bangkok, Thailand, November 3-5, 2006.
Invited talk entitled “Molecular Pathways of Silibinin Efficacy against Skin Cancer” at
University of Colorado Cancer Center Seminar Series, Aurora, CO, September 26 th,
2006.
Invited talk entitled “Molecular Pathways of Silibinin Efficacy against Skin Cancer” at
Nelson Institute of Environmental Medicine, NYU, Tuxedo, NY, September 22 nd,
2006.
Invited talk entitled “Skin Cancer Prevention by Silibinin” at 2006 International
Conference Frontiers of Pharmacology and Toxicology, Chicago, IL, August 29th,
2006.
Recipient of the 2006 Shell Award for Outstanding Achievement in Research and
Graduate Education, School of Pharmacy, UCDHSC, Denver, CO.
Invited talk entitled “Molecular Mechanism of Skin Cancer Chemoprevention by
Silibinin” at Division of Molecular Biology and Molecular Oncology, Evanston
Northwestern Research Institute, Evanston, IL, May 9th, 2006.
Invited talk entitled “Silibinin Efficacy against Prostate Cancer: Bench to Bedside” at
Karmanos Cancer Institute Grand Round Seminar Series, Detroit, MI, April 27th,
2006.
Invited talk entitled “Cell cycle regulators are potential targets for IP6 efficacy in
prostate cancer” at 2nd Developmental Therapeutics Program Retreat, UCCC, April
21st, 2006.
Invited talk entitled “Silibinin Efficacy against Prostate Cancer: Bench to Bedside” at
Penn State Cancer Institute, Hershey, PA, March 16 th, 2006.
Invited talk entitled “Molecular Mechanism of Skin Cancer Chemoprevention by
Silibinin” at Molecular Toxicology Seminar Series, Penn State University, University
Park, PA, March 15th, 2006.
Invited talk entitled “Molecular Mechanism of Skin Cancer Prevention by an
Antioxidant Flavonoid Silibinin” at Animal Cancer Center, Colorado State University,
Fort Collins, January 24th, 2006.
Invited talk entitled “Molecular Mechanisms of Skin Cancer Prevention by Silibinin”
at Department of Pharmacology and Toxicology, University of Alabama at
Birmingham, January 17th, 2006.
Invited talk entitled “Modulation of cell cycle regulators in prostate cancer prevention
by silibinin”. 3rd Joint Meeting of the Society for Free Radical Research Australia and
Japan, Gold Coast, December 2-5, 2005.
Visiting Scientist, Institute for Nutritional Sciences, Chinese Academy of Sciences,
Shanghai, China. October 22nd-28th, 2005.
Invited talk entitled “Prostate cancer prevention by silibinin”, Institute for Nutritional
Sciences, Chinese Academy of Sciences, Shanghai, China. October 2005.
Invited talk entitled “Prostate cancer prevention by silibinin – bench to bedside” at
Targeting Carcinogenesis, Rochester, MN, October 6th to 7th, 2005.
Invited talk entitled “IP6 prevents prostate cancer by modulating cell cycle
regulators”. 24th Annual Convention of IACR, New Delhi, India, February 9-12, 2005.
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Co-chair, Nutraceuticals and Cancer II Session, at the 3rd Int. Conf. on Mechanisms
of Action of Nutraceuticals, Asheville, NC, November 12-14, 2004.
Invited talk entitled “Molecular Mechanism of Silibinin Efficacy in Prostate Cancer” at
the 3rd Int. Conf. on Mechanisms of Action of Nutraceuticals, Asheville, NC,
November 12-14, 2004.
Co-chair, Session III at IP6 and Cell Signaling in Fighting Cancer: From Laboratory
to Clinic Symposium held at the 7th International Conference of Anticancer
Research, Corfu, Greece, October 25-30, 2004.
Invited talk entitled ”Prostate Cancer Prevention by IP6: Targeting Cell Cycle
Regulation” at IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic
Symposium held at the 7th International Conference of Anticancer Research, Corfu,
Greece, October 25-30, 2004.
Invited talk entitled “Prostate Cancer Chemoprevention by Silibinin” at Dietary
Factors and Cancer Prevention: Current Premises and Future Promises, Rochester,
MN, September 23-25, 2004.
Keynote talk entitled “Dietary Agents and Cancer Prevention: How Important Are
Pre-clinical Studies” at Pharmacy Student Research Conference, Western Region,
Denver, CO, June, 2004.
Invited talk entitled “Targeting cell signaling and cell cycle regulators: implications in
prostate cancer prevention by silibinin” at Basic Pharmaceutical Sciences Faculty
Seminar, School of Pharmacy, West Virginia University, Morgantown, WV, April,
2004.
Invited talk entitled “Molecular mechanism of skin cancer prevention by an
antioxidant flavonoid silibinin” at NIOSH, Morgantown, WV, April, 2004.
Co-chair, Session entitled “Prostate Cancer/Apoptosis” at 8 th World Congress on
Advances in Oncology, Crete, Greece, October 2003.
Invited talk entitled “Molecular Mechanism of Silibinin Efficacy in Prostate Cancer” at
8th World Congress on Advances in Oncology, Crete, Greece, October 2003.
Invited talk entitled “Prostate Cancer Prevention by Silibinin”. Hormel Institute,
University of Minnesota, September 25, 2003.
Invited talk entitled “Silibinin and Prostate Cancer: Targeting EGFR”. 21 st Annual
Meeting of the Moutain West Society of Toxicology, Breckenridge, CO, September
18-19, 2003.
Invited talk entitled “Modulation of cell cycle regulators by silibinin in prostate cancer”
at Basic Science Seminar Series, UC Cancer Center, UCHSC, Denver, CO, June
2003.
Invited talk entitled “EGFR is necessary and sufficient for silibinin efficacy: possible
role in prostate cancer” at Cell Biology Program Minisymposium – Receptor
Dynamics and Cancer, University of Colorado Cancer Center, UCHSC, Denver, CO,
April 2003.
Invited talk on Silibinin and Prostate Cancer at Integrative Medicine Program,
University of Colorado Hospital, Aurora, CO, November 2002.
Invited Speaker and Participant at 1st International Symposium on Cancer
Prevention, Montreal, Canada, November 2002.
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Rajesh Agarwal, Ph.D.
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Invited talk entitled Modulation of Cell Cycle Regulators in Prostate Cancer
Prevention by Silibinin at The Cell Cycle as a Target in Chemoprevention and
Cancer Therapy Conference, 3rd International Conference, Austin, TX, October
2002.
Invited talk entitled Silibinin: preclinical antitumor activity of a natural flavanolignan at
Catholic University of the Sacred Heart, sponsored by Prof. G. Scambia, Rome,
Italy, July 2002.
Invited talk entitle Silibinin and Prostate Cancer, and program planning and
development at Research Triangle Institute, North Carolina, April, 2002
Invited talk entitle Skin Cancer Chemoprevention by Silymarin at Basic Science
Seminars, University of Colorado Cancer Center, Denver, CO, April, 2002
Invited talk entitled Silymarin and Prostate Cancer: Epigenetic Events as Molecular
Targets at 1st International Conference on Mechanism of Action of Nutraceuticals,
Cavtat-Dubrovnik, Croatia, October 2001.
Invited talk entitled Silymarin and Skin Cancer Prevention at College of Pharmacy,
South Dakota State University, Brookings, SD, September 2001.
Talk entitled Upcoming Trial on Milk Thistle (Silymarin) at UCHSC Prostate Cancer
Support Group Meeting, Denver, CO, September 2001.
Invited talk entitled Skin Cancer Chemoprevention by Silymarin at Department of
Dermatology, Columbia University, New York, NY, August 2001.
Talk entitled Phytochemicals and Cancer Prevention – An Overview at DOPS,
UCHSC Annual Retreat, Winter Park, CO, June 2001.
Invited Speaker at University of Illinois at Chicago, Department of Pharmaceutics
and Pharmacodynamics, Chicago, IL, November 2000.
Invited Speaker at Exp. Skn Carcinogenesis: 4th International Meeting, Tucson, AZ,
2000.
Invited Speaker at University of Pittsburgh. Department of Cell Biology & Physiology,
Pittsburgh, PA, October 2000.
Invited Speaker at McGill University, Montreal, Canada, October 2000.
Invited Speaker at Mercy Hospital Cancer Research Institute, Pittsburgh, PA, June
2000.
Inaugoral Talk at AMC Cancer Research Center 2000 – Seminar Series, January
2000.
Invited Speaker at International Conference on Signal Transduction as Molecular
Targets for Therapy, Luxembourg, Luxembourg, January 2000.
Invited Speaker at Univ. of Colorado Cancer Center, Denver, CO, December 1999.
Invited Speaker at Department of Endocrinology, University of Colorado Health
Sciences Center, Denver, CO, December 1999.
Invited Speaker at International Conference on Diet and Prevention of Cancer,
Tampere, Finland, 1999.
Invited speaker at Comprehensive Cancer Center, Ohio State University, OH, 1998.
Invited speaker at Exp. Skin Carcinogenesis: 3rd International Meeting, TX, 1998.
My work showing exceptionally high protective effect of silymarin against
photocarcinogenesis, was covered nationally on TV, radio as well as in several
magazines including CWRU Medical School’s MedLines, 1997.
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Rajesh Agarwal, Ph.D.
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Work “Anti-carcinogenic effect of a polyphenolic antioxidant silymarin in breast
cancer cells MDA-MB468: a p53-independent induction of WAF1/Cip1/p21 and G1
arrest” received an AACR-AFLAC Young Investigator Award for the 88th Annual
Meeting of AACR, 1997.
Invited speaker at MD Anderson Cancer Center, Science Park, Smithville, TX, 1996.
Recipient of Upjohn Company Foundation Career Development Award through
Dermatology Foundation, 1995.
Chaired an Oral Session entitled ‘Mechanism of Carcinogenesis’ at 56 th Annual
Meeting of The Society for Investigative Dermatology, 1995.
Chaired an Oral Session entitled ‘UV Photobiology’ at 23 rd Annual Meeting of
American Society for Photobiology, 1995.
Invited speaker at Department of Dermatology, Roswell Park Cancer Center,
Buffalo, 1994.
Recipient of Upjohn Company Foundation Career Development Award through
Dermatology Foundation, 1994.
Recipient of Upjohn Company Foundation Career Development Award through
Dermatology Foundation, 1993.
Recipient of Young Investigator Travel Award through Organizing Committee to
Attend Second Tricontinental Meeting of the JSID, SID and ESDR held at Kyoto,
Japan, October 28-31, 1993.
Recipient of Lila Gruber Cancer Research Award of the American Academy of
Dermatology through Dermatology Foundation, 1992.
Recipient of Robert A. Chesebrough Silver Medal from Chesebrough-Pond’s Inc. for
original research work entitled “Effect of VaselineR Petroleum Jelly on absorption,
tissue distribution, metabolism and DNA binding of skin carcinogen benzo(a)pyrene,
1990.
Recipient of Robert A. Chesebrough Bronze Medal from Chesebrough-Pond’s Inc.
for original research paper entitled “Effect of Vaseline R Petroleum Jelly on benzoyl
peroxide-induced ornithine decarboxylase activity in mouse skin, 1990.
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Rajesh Agarwal, Ph.D.
Publications
JOURNAL PUBLICATIONS
In the Area of Bio-Organic Chemistry (1979-1989)
1. Tiwari, S.S., Satsangi, R.K., and Agarwal, R.: Synthesis and CNS activity of some
2-aryl/alkyl-3-[N-phenyl, N-(dihydroxy phenylmethyl)-amino]-6, 8-disubstitutedquinazolin-4 (3H)-ones. Curr. Sci., 48:568-571, 1979.
2. Tiwari, S.S., Zaidi, S.M.M., Agarwal, R., and Satsangi, R.K.: 5-Nitro-4(2)-[4-oxo-3Hquinazolin-3yl]-benzylidene malonylureas as antibacterial agents. J. Ind. Chem.
Soc., 57:1039-1040, 1980.
3. Tiwari, S.S., Agarwal, R., and Satsangi, R.K.: Synthesis and CNS activity of 1(5’alkyl-1’,3’,4’-thiadiazol-2’-yl)-2-methyl-4-arylidene-imidazol-5 ones. J. Ind. Chem.
Soc., 57:1040-1042, 1980.
4. Zaidi, S.M.M., Satsangi, R.K., Kumar, P., Nasir, M., Agarwal, R., and Tiwari, S.S.:
New anti-mycobacterial hydantoins. Die Pharmazie, 35:740-741, 1980.
5. Agarwal, R., Shukla, M.K., and Satsangi, R.K.: Synthesis and CNS activity of 5arylidene-3-arylaminomethyl-4-thiazolidinon-2-thiones. Curr. Sci., 49:455-456, 1980.
6. Agarwal, R., Satsangi, R.K., Misra, S., and Tiwari, S.S.: Synthesis and CNS activity
of 2-aryl-3-(substituted-phenoxy-acetyl hydrazono)-methylenyl-indoles. Curr. Sci.,
50:66-68, 1981.
7. Tiwari, S.S., Agarwal, R., and Satsangi, R.K.: Search for CNS active agents:
Synthesis of N,N’-bis-[potassium-alkly/aryl-carboxylate]-5-arylidene barbituric acids.
Pol. J. Pharmacol. Pharm., 33:115-120, 1981.
8. Agarwal, R., Shukla, M.K., Satsangi, R.K., and Chaudhary, C.: Synthesis of 1-{p-[3(2’oxo/thiobenzoxazolinyl methyl)-amino] benzoyl}-4-aryl/methyl-piperazines as CNS
active agents. Ind. J. Chem., 20B:680-682, 1981.
9. Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activity of 1,5disubstituted-3-(4’-acetamidophenoxyacetyl hydrazono) indolin-2-ones. Ind. J.
Chem., 20B:1099-1100, 1981.
10. Misra, S., Satsangi, R.K., Agarwal, R., and Tiwari, S.S.: Synthesis of 2-substituted
phenyl-3-aryloxyacetyl hydrazono methylenyl-indoles as central nervous system
active agents. J. Chem. Soc. Pak., 3:199-202, 1981.
11. Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Chemistry and CNS activity of 1-(4methyl-coumarin-7yl)-oxyacetyl-3-methyl-4-(substituted-phenylhydrazono/azo)
pyrazolin-5-ones. J. Chem. Soc. Pak., 3:203-208, 1981.
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Rajesh Agarwal, Ph.D.
12. Misra, V.S., Singh, C., Agarwal, R., and Chaudhary, C.: Synthesis of 2-styryl-3,6,8trisubstituted quinazolin-4(3H) ones as anti-inflammatory agents. J. Chem. Soc.
Pak., 3:209-213, 1981.
13. Agarwal, R., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activities of some
newer indole derivatives. J. Chem. Soc. Pak., 4:43-47, 1982.
14. Agarwal, R., Chaudhary, C., Srivastava, V.K., and Misra, V.S.: Synthesis of 1-(2aryl- indol-3yl)-2-[3-(p-substituted phenyl)-6-substituted-quinazolin-4-one-2yl]ethenes as CNS active agent. Acta Pharm. Jugosl., 32:37-44, 1982.
15. Agarwal, R., Chaudhary, C., and Misra, V.S.: Effect of mild bases on the yield of
Knoevenagel products: Synthesis of some N1-substituted 4-arylidene-3-methyl-_2pyrazolin-5-ones under different basic conditions. Ind. J. Chem., 21B:109-111,
1982.
16. Agarwal, R., Chaudhary, C., Singh, C., and Misra, V.S.: Synthesis of 2-methoxy4(3-methyl-5-oxo 1-phenyl-4-pyrazolylidenemethyl)-phenoxyacetic acid and its ethyl
ester. Ind. J. Chem., 21B:152-153, 1982.
17. Agarwal, R., Misra, S., Satsangi, R.K., and Tiwari, S.S.: Synthesis and CNS activity
of N,N-disubstituted-1-(aminomethyl)-5-alkyl-3-(aryloxyacetyl hydrazono) indolin-2ones. Arch. Pharm., 315:142-146, 1982.
18. Agarwal, R., Shukla, M.K., and Satsangi, R.K.: Synthesis and CNS activity of 4-aryl1-p-(substituted benzamido)-piperazines. Ind. J. Pharm., 14:177-182, 1982.
19. Misra, V.S., Chaudhary, C., and Agarwal, R.: Synthesis of N1-(2,4-dinitrophenyl
acetyl)-3-methyl-4-(substituted phenyl-hydrazono/azo)-pyrazolin-5-ones. Ind. J.
Chem., 21B:466-467, 1982.
20. Singh, C., Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis of 1-(N,Ndisubstituted-aminomethyl)-2-oxo-3-(2,4-dinitrophenylacetyl hydrazono)-5substituted-indoles as anti-inflammatory agents. J. Chem. Soc. Pak., 4:215-219,
1982
21. Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis and CNS activity of 4arylideneamino-N,N-diphenylbenzamides, 1-[p-(N,N diphenylcarbamoyl) phenyl]-3(p-substituted phenyl) thioureas and 6-substituted 3-[N-(3H-2-methyl-4-oxo-3quinazolylamino)methyl] 2-oxo/thio-benzoxazoles. Ind. J. Chem., 21B:1110-1113,
1982.
22. Chaudhary, C., Agarwal, R., and Misra, V.S.: Synthesis of 2-aryl-3-(3-disubstituted
aminomethyl-2-thio-4-oxo-thiazolidin-5yl)-methylenyl-indoles as CNS active agents.
Proc. Ind. Acad. Sci., 91:483-489, 1982.
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Rajesh Agarwal, Ph.D.
23. Agarwal, R., Chaudhary, C., and Misra, V.S.: Synthesis of 2-aryl-1-(4morpholinophenyl)-4-(3,4-disubstituted-benzylidene) imidazolin-5-ones as CNS
active agents. Ind. J. Chem., 22B:308-310, 1983.
24. Singh, C., Agarwal, R., and Misra, V.S.: Synthesis of 2-thio 3-arylamino/
disubstituted amino-methyl-4-oxo-5-cinnamylidene-thiazolidines as CNS and antiinflammatory agents. Curr. Sci., 52:305-308, 1983.
25. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis and pharmacological
screening of 2-thio-3-arylaminomethyl-4-oxo-5-(3,4-disubstituted benzylidene)
thiazolidines. Indian Drugs, 21:90-95, 1983.
26. Agarwal, C., Agarwal, R., Gupta, P.N., Srivastava, V.K., and Misra, V.S.: Synthesis
of 1-dialkylaminomethyl-2-oxo-3-(3’-cyclohexylpropanonyl) hydrazono-5-substituted
indoles as possible psychotropic agents. Acta Pharm. Jugosl., 33:183-192, 1983.
27. Mohan, R.R., Agarwal, C., Agarwal, R., and Misra, V.S.: CNS, anthelmintic and
anti-inflammatory activities of some 1-[2/3-(2-phenyl benzimidazole] 2methyl/phenyl-4 (3,4-disubstituted benzylidene) 5-oxo-imidazoles. Pharm. Res.
Comm., 16:321-338, 1984.
28. Agarwal, R., Agarwal, C., Singh, C., and Misra, V.S.: Synthesis of 1-(2-arylindol3yl)- 2[3-(p-morpholinophenyl)- 6,8-disubstituted-quinazolin- 4(3H)- one-2yl] ethenes
as CNS active and anti-inflammatory agents. J. Chem. Soc. Pak., 6:89-94, 1984.
29. Agarwal, R., Agarwal, C., and Kumar, P.: Antitubercular and CNS activities of some
2-aryl-3- [N-(2/3/4-benzimidazol-2yl)phenyl]- iminomethylenyl-indoles. Pharm. Res.
Comm., 16:831-844, 1984.
30. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of some newer quinazolinyloxadiazoles, thiosemicarbazides and thiadiazoles as pharmacologically active
agents. Ind. J. Chem., 24B:78-82, 1985.
31. Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of 2/9-substituted
indophenazin-6-aryl/methyl benzylidene hydrazides, 4-aryl-1(indophenazin-6-methylcarbonyl)-3-thiosemicarbazides and 6-(4-aryl-5-mercapto4H-1,2,4-triazol-3yl methyl) indophenazines as CNS active and anti-inflammatory
agents. Ind. J. Chem., 25B:1234-1237, 1986.
32. Agarwal, R., Bhargava, S.K., Kidwai, M.M., Mehrotra, N.K., and Lal, M.M.:
Estimation of benzo(a)pyrene in ambient air of different areas of Lucknow city.
Proceedings of National Symposium on chemical carcinogenesis and carcinogens in
the environment. 136-138, 1988.
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Rajesh Agarwal, Ph.D.
33. Agarwal, R., Agarwal, C., Singh, C., Mohan, R.R., and Misra, V.S.: Synthesis of 6substituted indophenazines as possible psychotropic and anti-inflammatory agents.
Acta Pharm. Jugosl., 38:11-21, 1988.
34. Agarwal, R., Singh, C., and Misra, V.S.: CNS and anti-inflammatory activities of
some newer oxo-imidazolidenes. Indian Drugs, 25:185-190, 1988.
35. Agarwal, R., Agarwal, C., Singh, C., and Misra, V.S.: Synthesis of 1-substituted-2oxo-3-chloro/(2-chlorophenoxy)-4-(2 arylindol-3yl) azetidines as CNS active and
antiinflammatory agents. Ind. J. Chem., 28B:893-896, 1989.
In the Areas of Biological Sciences and Cancer Biology/Pharmacology
(1985 to date)
36. Agarwal, R., Kumar, S., Shukla, Y., Antony, M., and Mehrotra, N.K.: Quantification
of tumour initiating effect of Jute Batching Oil and its distillates over mouse skin.
Cancer Lett., 28:281-290, 1985.
37. Agarwal, R., Kumar, S., and Mehrotra, N.K.: Polyaromatic hydrocarbon profile of a
mineral oil (JBO-P) by gas chromatography. J. Chrom. Sci., 24:289-292, 1986.
38. Agarwal, R., Gupta, K.P., Kumar, S., and Mehrotra, N.K.: Assessment of some
tumourigenic risks associated with fresh and used cutting oil. Ind. J. Exptl. Biol.,
24:508-510, 1986.
39. Mehrotra, N.K., Kumar, S., Agarwal, R., and Antony, M.: Jute Batching oil: a tumor
promoter on mouse skin. Environ. Res., 42:12-23, 1987.
40. Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Evaluation of carcinogenic
effect of jute batching oil (JBO-P) fractions following topical application to mouse
skin. Arch. Toxicol., 62:406-410, 1988.
41. Rajasekharan, K.N., Mayadevi, M., Agarwal, R., and Burke, M.: MgADP-induced
changes in the structure of myosin S1 near the ATPase-related thiol SH1 probed by
cross-linking. Biochemistry, 29:3006-3013, 1990.
42. Agarwal, R., Athar, M., Bickers, D.R., and Mukhtar, H.: Evidence for the
involvement of singlet oxygen in the photodestruction by chloroaluminum
phthalocyanine tetrasulfonate. Biochem. Biophys. Res. Commun., 173:34-41, 1990.
43. Agarwal, R., Rajasekharan, K.N. and Burke, M.: Identification of the site of
photocross-linking formed in the absence of magnesium nucleotide from SH2 (cys697) in myosin subfragment 1 labeled with 4’-maleimidylbenzophenone. J. Biol.
Chem., 266:2272-2275, 1991.
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Rajesh Agarwal, Ph.D.
44. Wang, Z.Y., Agarwal, R., Zhou, Z.C., Bickers, D.R. and Mukhtar, H.: Inhibition of
mutagenicity in Salmonella typhimurium and skin tumor initiating and tumor
promoting activities in Sencar mice by glycyrrhetinic acid: Comparison of 18- and
18-stereoisomers. Carcinogenesis, 12:187-192, 1991.
45. Agarwal, R., Athar, M., Urban, S.A., Bickers, D.R., and Mukhtar, H.: Involvement of
singlet oxygen in chloroaluminum phthalocyanine tetrasulfonate-mediated
photoenhancement of lipid peroxidation in rat epidermal microsomes. Cancer Lett.,
56:125-129, 1991.
46. Agarwal, R., Wang, Z.Y., and Mukhtar, H.: Inhibition of skin tumor initiating activity
of DMBA by chronic oral feeding of glycyrrhizin in drinking water. Nutrition and
Cancer, 15:187-193, 1991.
47. Agarwal, R., Wang, Z.Y., Bik, D.P., and Mukhtar, H.: Nordihydroguaiaretic acid, an
inhibitor of lipoxygenase, also inhibits cytochrome P 450-mediated monooxygenase
activity in rat epidermal and hepatic microsomes. Drug Metab. Dispos., 19:620-624,
1991.
48. Wang, Z.Y., Agarwal, R., Bickers, D.R., and Mukhtar, H.: Protection against
ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea
polyphenols. Carcinogenesis, 12:1527-1530, 1991.
49. Agarwal, R. and Burke, M.: Temperature induced changes in the flexibility of the
loop between SH1 (cys-707) and SH3 (cys-522) in myosin subfragment 1 detected
by cross-linking. Arch. Biochem. Biophys., 290:1-6, 1991.
50. Agarwal, R., Medrano, E.E., Khan, I.U., Nordlund, J.J. and Mukhtar, H.: Metabolism
of benzo(a)pyrene by human melanocytes in culture. Carcinogenesis, 12:19631966, 1991.
51. Wang, Z.Y., Agarwal, R., Zhou, Z.C., Bickers, D.R. and Mukhtar, H.: Antimutagenic
and antitumorigenic activities of nordihydroguaiaretic acid. Mutation Res., 261:153162, 1991.
52. Athar, M., Agarwal, R., Wang, Z.Y., Lloyd, J.R., Bickers, D.R. and Mukhtar, H.: All
trans retinoic acid protects against conversion of chemically induced- and ultraviolet
B radiation-induced skin papillomas to carcinomas. Carcinogenesis, 12:2325-2329,
1991.
53. Mukhtar, H., Agarwal, R., Athar, M., Lewen, R.L., Elmets, C.A., and Bickers, D.R.:
Photodynamic therapy of murine skin tumors by Photofrin II. Photodermatol.
Photoimmunol. Photomed., 8:169-175, 1991.
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Rajesh Agarwal, Ph.D.
54. Raza, H., Agarwal, R., Bickers, D.R., and Mukhtar, H.: Purification and molecular
-naphthoflavone- inducible cytochrome P-450 from rat
epidermis. J. Invest. Dermatol., 98:233-240, 1992.
55. Agarwal, R., Zaidi, S.I.A., Athar, M., Bickers, D.R. and Mukhtar, H.: Photodynamic
effects of chloroaluminum phthalocyanine tetrasulfonate are mediated by singlet
oxygen: in vivo and in vitro studies utilizing hepatic microsomes as model
membrane source. Arch. Biochem. Biophys., 294:30-37, 1992.
56. Mukhtar, H., Wang, Z.Y., Katiyar, S.K. and Agarwal, R.: Tea components:
Antimutagenic and anticarcinogenic effects. Preventive Medicine, 21:351-360, 1992.
57. Agarwal, R., Katiyar, S.K., Zaidi, S.I.A. and Mukhtar, H.: Inhibition of skin tumor
promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice
by polyphenolic fraction isolated from green tea and its individual epicatechin
derivatives. Cancer Res., 52:3582-3588, 1992.
58. Agarwal, R., Athar, M., Elmets, C.A., Bickers, D.R. and Mukhtar, H.: Photodynamic
therapy of chemically- and ultraviolet B radiation-induced murine skin papillomas by
chloroaluminum phthalocyanine tetrasulfonate. Photochem. Photobiol., 56:43-50,
1992.
59. Khan, S.G., Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Enhancement of
antioxidant and phase II enzymes by oral feeding of green tea polyphenols in
drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
Cancer Res., 52:4050-4052, 1992.
60. Wang, Z.Y., Agarwal, R., Khan, W.A. and Mukhtar, H.: Protection against
benzo(a)pyrene and N-nitrosodiethylamine-induced lung and forestomach
tumorigenesis in A/J mice by water extracts of green tea and licorice.
Carcinogenesis, 13:1491-1494, 1992.
61. Katiyar, S.K., Agarwal, R., Wang, Z.Y., Bhatia, A.K. and Mukhtar, H.: (-)Epigallocatechin-3-gallate in Camellia sinensis leaves from Himalayan region of
Sikkim: Inhibitory effects against biochemical events and tumor initiation in SENCAR
mouse skin. Nutrition and Cancer, 18:73-83, 1992.
62. Agarwal, R., Raza, H., Allyn, D.L., Bickers, D.R. and Mukhtar, H.: Glutathione Stransferase dependent conjugation of leukotriene A4 methyl ester to leukotriene C4
methyl ester in mammalian skin. Biochem. Pharmacol., 44:2047-2053, 1992.
63. Katiyar, S.K., Agarwal, R., Wood, G.S. and Mukhtar, H.: Inhibition of 12-Otetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction
isolated from green tea. Cancer Res., 52:6890-6897, 1992.
25
Rajesh Agarwal, Ph.D.
64. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Green tea in chemoprevention of
cancer. Comprehensive Therapy, 18:3-8, 1992.
65. Katiyar, S.K., Agarwal, R., Ekker, S., Wood, G.S. and Mukhtar, H.: Protection
against 12-O-tetradecanoylphorbol-13-acetate-caused inflammation in SENCAR
mouse ear skin by polyphenolic fraction isolated from green tea. Carcinogenesis,
14:361-365, 1993.
66. Katiyar, S.K., Agarwal, R., Zaim, M.T. and Mukhtar, H.: Protection against Nnitrosodiethylamine and benzo(a)pyrene-induced forestomach and lung
tumorigenesis in A/J mice by green tea. Carcinogenesis, 14:849-855, 1993.
67. Sutter, C., Strickland, P.T., Mukhtar, H., Agarwal, R., Winter, H. and Schweizer, J.:
Ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiationinduced epidermal neoplasias of mouse skin. Mol. Carcinogenesis, 8:13-19, 1993.
68. Zaidi, S.I.A., Agarwal, R., Eichler, G., Rihter, B.D., Kenney, M.E. and Mukhtar, H.:
Photodynamic effects of new silicon phthalocyanines: in vitro studies utilizing rat
hepatic microsomes and human erythrocyte ghosts as model membrane sources.
Photochem. Photobiol., 58:204-210, 1993.
69. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against malignant conversion
of chemically-induced benign skin papillomas to squamous cell carcinomas in
SENCAR mice by a polyphenolic fraction isolated from green tea. Cancer Res.,
53:5409-5412, 1993.
70. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protective effects of green tea
polyphenols administered by oral intubation against chemical carcinogen-induced
forestomach and pulmonary neoplasia in A/J mice. Cancer Letters, 73:167-172,
1993.
71. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of both stage I and stage II
skin tumor promotion in SENCAR mice by a polyphenolic fraction isolated from
green tea: Inhibition depends on the duration of polyphenol treatment.
Carcinogenesis, 14:2641-2643, 1993.
72. Agarwal, R., Katiyar, S.K., Khan, S.G. and Mukhtar, H.: Protection against
ultraviolet B radiation-induced effects in the skin of SKH-1 hairless mice by a
polyphenolic fraction isolated from green tea. Photochem. Photobiol., 58: 695-700,
1993.
73. Agarwal, R., Khan, S.G., Athar, M., Zaidi, S.I.A., Bickers, D.R. and Mukhtar, H.: Ras
protein p21 processing enzyme farnesyltransferase in chemical carcinogen-induced
murine skin tumors. Mol. Carcinogenesis, 8:290-298, 1993.
26
Rajesh Agarwal, Ph.D.
74. Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Green tea and skin - anticarcinogenic
effects. J. Invest. Dermatol., 102:3-7, 1994.
75. Agarwal, R., Jugert, F.K., Khan, S.G., Bickers, D.R., Merk, H.F. and Mukhtar, H.:
Evidence for multiple inducible cytochrome P450 isozymes in SENCAR mouse skin
by pyridine. Biochem. Biophys. Res. Commun., 199:1400-1406, 1994.
76. Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Ras p21 farnesylation in
ultraviolet B radiation-induced tumors in the skin of SKH-1 hairless mice. J. Invest.
Dermatol., 102:754-758, 1994.
77. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of spontaneous and photoenhanced lipid peroxidation in mouse epidermal microsomes by epicatechin
derivatives from green tea. Cancer Lett., 79:61-66, 1994.
78. Jugert, F.K., Agarwal, R., Kuhn, A., Bickers, D.R., Merk, H.F. and Mukhtar, H.:
Multiple cytochrome P450 isozymes in murine skin: Induction of P450 1A, 2B, 2E
and 3A by dexamethasone. J. Invest. Dermatol., 102:970-975, 1994.
79. Agarwal, R., Katiyar, S.K., Lundgren, D.W. and Mukhtar, H.: Inhibitory effect of
silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetateinduced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice.
Carcinogenesis, 15:1099-1103, 1994.
80. Mukhtar, H., Zaidi, S.I.A., Raza, H. and Agarwal, R.: Differential expression of
glutathione S-transferase isozymes in murine and human skin tumors. Int. J.
Oncology, 6:37-43, 1995.
81. Khan, S.G., Saxena, R., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Inhibition of
ras p21 membrane localization and modulation of protein kinase C isozyme
expression during regression of chemical carcinogen-induced murine skin tumors by
lovastatin. Mol. Carcinogenesis, 12:205-212, 1995.
82. Khan, S.G., Mukhtar, H. and Agarwal, R.: A rapid and convenient filter-binding
assay for ras p21 processing enzyme farnesyltransferase. J. Biochem. Biophys.
Methods, 30:133-144, 1995.
83. Agarwal, R. and Mukhtar, H.: Cancer chemoprevention by polyphenolic compounds
present in green tea. Drug News & Perspective, 8:216-225, 1995.
84. Katiyar, S.K., Rupp, C.O., Korman, N.J., Agarwal, R. and Mukhtar, H.: Inhibition of
12-O-tetradecanoylphorbol-13-acetate and other skin tumor promoter-caused
induction of epidermal interleukinmice by green tea polyphenols. J. Invest. Dermatol., 105:394-398, 1995.
27
Rajesh Agarwal, Ph.D.
85. Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Protection against
ultraviolet B radiation-induced local and systemic suppression of contact
hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols.
Photochem. Photobiol., 62:855-861, 1995.
86. Khan, S.G., Mohan, R.R., Katiyar, S.K., Wood, G.S., Bickers, D.R., Mukhtar, H. and
Agarwal, R.: Mutations in ras oncogenes: Rare event in ultraviolet B radiationinduced mouse skin tumorigenesis. Mol. Carcinogenesis, 15:96-103, 1996.
87. Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promotion in
SENCAR mouse skin by ethanol extract of Gingiber officinale rhizome. Cancer Res.,
56:1023-1030, 1996.
88. Agarwal, R. and Mukhtar, H.: Chemoprevention of photocarcinogenesis.
Photochem. Photobiol., 63:440-444, 1996.
89. Agarwal, R., Korman, N.J., Mohan, R.R., Jawed, S., Zaim, M.T. and Mukhtar, H.:
Apoptosis is an early event during phthalocyanine-photodynamic therapy-induced
ablation of murine skin tumors. Photochem. Photobiol., 63:547-552, 1996.
90. Khan, S.G., Dummer, R., Siddiqui, J, Bickers, D.R., Agarwal, R. and Mukhtar, H.:
Farnesyltransferase activity and mRNA expression in human skin basal cell
carcinomas. Biochem. Biophys. Res. Commun., 220:795-801, 1996.
91. Mohan, R.R., Katiyar, S.K., Khan, S.G., Zaim, M.T., Mukhtar, H. and Agarwal, R.:
Protective effect of all trans retinoic acid against tumor promotion and progression in
low- and high-risk protocols of mouse skin chemical carcinogenesis. Int. J.
Oncology, 8:1079-1088, 1996.
92. Mukhtar, H. and Agarwal, R.: Skin cancer chemoprevention. J. Invest. Dermatol.
Symposium Proceedings, 1:209-214, 1996.
93. Agarwal, R., Mohan, R.R., Ahmad, N. and Mukhtar, H.: Protection against
malignant conversion in SENCAR mouse skin by all trans retinoic acid: Inhibition of
the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane
localization. Mol. Carcinogenesis, 17:13-22, 1996.
94. Ahmad, N., Agarwal, R. and Mukhtar, H.: Cytochrome P450-dependent drug
metabolism in skin. Clinics in Dermatol., 14:407-415, 1996.
95. Singh, S.V., Mohan, R.R., Agarwal, R., Benson, P.J., Hu, X., Rudy, M.A., Xia, H.,
Katoh, A., Srivastava, S.K., Mukhtar, H., Gupta, V. and Zaren, H.A.: A novel anticarcinogenic activity of an organosulfide from garlic: Inhibition of H-ras oncogene
transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of
p21H-ras processing. Biochem. Biophys. Res. Commun., 225:660-665, 1996.
28
Rajesh Agarwal, Ph.D.
96. Chatterjee, M.L., Agarwal, R. and Mukhtar, H.: Ultraviolet B radiation-induced DNA
lesions in mouse epidermis: an assessment using a novel 32P-postlabelling
technique. Biochem. Biophys. Res. Commun., 229:590-595, 1996.
97. Ahmad, N., Agarwal, R. and Mukhtar, H.: Cytochrome P450 and drug development
for skin diseases. Skin Pharmacol., 9:231-241, 1996.
98. Katiyar, S.K., Mohan, R.R., Agarwal, R. and Mukhtar, H.: Protection against
induction of mouse skin papillomas with low- and high-risk for conversion to
malignancy by green tea polyphenols. Carcinogenesis, 18:497-502, 1997.
99. Ahmad, N., Srivastava, R.C., Agarwal, R. and Mukhtar, H.: Nitric oxide synthase
and skin tumor promotion. Biochem. Biophys. Res. Commun., 232:328-331, 1997.
100. Katiyar,
S.K., Korman, N.J., Mukhtar, H. and Agarwal, R.: Protective effects of
silymarin against photocarcinogenesis in mouse skin model. J. Natl. Cancer Inst.,
89: 556-566, 1997.
101. Srivastava,
S.K., Hu, X., Xia, H., Zaren, H.A., Chatterjee, M.L., Agarwal, R. and
Singh, S.V.: Mechanism of differential efficacy of organosulfides in preventing
benzo(a)pyrene-induced cancer in mice. Cancer Lett., 118: 61-67, 1997.
102. Ahmad,
N., Feyes, D.K., Nieminen, A.-L., Agarwal, R. and Mukhtar, H.: Green tea
constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle
arrest in human carcinoma cells. J. Natl. Cancer Inst., 89:1881-1886, 1997.
103. Zi,
X., Mukhtar, H. and Agarwal, R.: Novel cancer chemopreventive effects of a
flavonoid antioxidant silymarin: Inhibition of mRNA expression of an endogenous
-339, 1997.
104. Zi,
X., Feyes, D.K. and Agarwal, R.: Anti-carcinogenic effect of a flavonoid
antioxidant silymarin in human breast cancer cells MDA-MB 468: Induction of G1
arrest through an increase in Cip1/p21 concomitant with a decrease in kinase
activity of CDKs and associated cyclins. Clin. Cancer Res., 4: 1055-1064, 1998.
105. Zi,
X., Grasso, A.W., Kung, H.-J. and Agarwal, R.: A flavonoid antioxidant silymarin
inhibits activation of erbB1 signaling, and induces cyclin-dependent kinase
inhibitors, G1 arrest and anti-carcinogenic effects in human prostate carcinoma
DU145 cells. Cancer Res., 58: 1920-1929, 1998.
106. Ahmad,
N., Gali, H., Javed, S. and Agarwal, R.: Skin cancer chemopreventive
effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor
tyrosine kinase signaling and perturbation in cell cycle progression. Biochem.
Biophys. Res. Commun., 247: 294-301, 1998.
29
Rajesh Agarwal, Ph.D.
107. Ahmad,
N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: Photodynamic therapy
results in induction of WAF1/CIP1/P21 leading to cell cycle arrest and apoptosis.
Proc. Natl. Aca. Sci. USA, 95: 6977-6982, 1998.
108. Mohan,
R.R., Challa, A., Gupta, S., Bostwick, D.G., Ahmad, N., Agarwal, R.,
Marengo, S.R., Amini, S.B., MacLennan, G.T., Paras, F., Resnick, M.I. and Mukhtar,
H.: Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid
in humans. Clin. Cancer Res., 5:143-147, 1999.
109. Lahiri-Chatterjee,
M., Katiyar, S.K., Mohan, R.R. and Agarwal, R.: A flavonoid
antioxidant, silymarin, affords exceptionally high protection against tumor promotion
in SENCAR mouse skin tumorigenesis model. Cancer Res., 59:622-632, 1999.
110. Zi,
X. and Agarwal, R.: Silibinin decreases prostate-specific antigen with cell growth
inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells:
Implications for prostate cancer intervention. Proc. Natl. Acad. Sci. USA, 96:74907495, 1999.
111. Zhao,
J., Wang, J., Chen, Y. and Agarwal, R.: Anti-tumor promoting activity of a
polyphenolic fraction isolated from grape seeds in mouse skin two-stage initiationpromotion protocol, and identification of procyanidin B5-3’-gallate as the most
effective antioxidant constituent. Carcinogenesis, 20:1737-1745, 1999.
112. Zhao,
J. and Agarwal, R.: Tissue distribution of silibinin, the major active
constituent of silymarin, in mice and its association with enhancement of phase II
enzymes: Implications in cancer chemoprevention. Carcinogenesis, 20: 2101-2108,
1999.
113. Bhatia,
N., Zhao, J., Wolf, D.M. and Agarwal, R.: Inhibition of human carcinoma
cell growth and DNA synthesis by silibinin, an active constituent of milk thistle:
comparison with silymarin. Cancer Letts., 147: 77-84, 1999.
114. Zi,
X. and Agarwal, R.: Modulation of mitogen-activated protein kinase activation
and cell cycle regulators by the potent skin cancer preventive agent silymarin.
Biochem. Biophys. Res. Commun., 263: 528-536, 1999.
115. Zhao,
J., Sharma, Y. and Agarwal, R.: Significant inhibition by the flavonoid
antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused
modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and
interlukin-1 expression in SENCAR mouse epidermis: implications in the
prevention of stage I tumor promotion. Mol. Carcinogenesis, 26: 321-333, 1999.
116. Zhao,
J., Lahiri-Chatterjee, M., Sharma, Y. and Agarwal, R.: Inhibitory effect of a
flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion,
oxidative stress and inflammatory responses in SENCAR mouse skin.
Carcinogenesis, 21: 811-816, 2000.
30
Rajesh Agarwal, Ph.D.
117. Agarwal,
C., Sharma, Y., Zhao, J. and Agarwal, R.: A polyphenolic fraction from
grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468
cells by inhibiting mitogen-activated protein kinases activation and inducing G1
arrest and differentiation. Clinical Cancer Res., 6: 2921-2930, 2000.
118. Agarwal,
C., Sharma, Y. and Agarwal, R.: Anticarcinogenic effect of a polyphenolic
fraction isolated from grape seeds in human prostate carcinoma DU145 cells:
modulation of mitogenic signaling and cell cycle regulators and induction of G1
arrest and apoptosis. Mol. Carcinogenesis, 28: 129-138, 2000.
119. Jiang,
C., Agarwal, R. and Lu, J.: Anti-angiogenic potential of silymarin: inhibition of
key attributes of vascular endothelial cells and angiogenic cytokine secretion by
cancer epithelial cells. Biochem. Biophys. Res. Commun., 276: 371-378, 2000.
120. Zi,
X, Zhang, J., Agarwal, R. and Pollak, M.: Silibinin up-regulates insulin-like
growth factor-binding protein 3 expression and inhibits proliferation of androgenindependent prostate cancer cells. Cancer Res. (Advances in Brief), 60: 5617-5620,
2000.
121. Agarwal,
R.: Cell signaling and regulators of cell cycle as molecular targets for
prostate cancer prevention by dietary agents. Biochemical Pharmacol., 60: 10511059, 2000.
122. Zi,
X., Singh, Rana P. and Agarwal, R.: Impairment of erbB1 receptor and fluidphase endocytosis and associated mitogenic signaling by inositol hexaphosphate in
human prostate carcinoma DU145 cells. Carcinogenesis, 21: 2225-2235, 2000.
123. Bhatia,
N. and Agarwal, R.: Detrimental effect of cancer preventive phytochemicals
silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human
prostate carcinoma DU145 cells. Prostate, 46: 98-107, 2001.
124. Sharma,
Y., Agarwal, C., Singh, A.K. and Agarwal, R.: Inhibitory effect of silibinin
on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA
synthesis in advanced human prostate carcinoma cells. Mol. Carcinogenesis, 30:
224-236, 2001.
125. Bhatia,
N., Agarwal, C. and Agarwal, R.: Differential response of skin cancer
chemopreventive agent silibinin, quercetin and epigallocatechin 3-gallate on
mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431
cells. Nutrition and Cancer, 39: 292-299, 2001.
31
Rajesh Agarwal, Ph.D.
After Joining DOPS, SOP, UCHSC
126. Dhanalakshmi, S., Singh, R.P., Agarwal, C and Agarwal, R.: Silibinin inhibits
constitutive and TNF-induced activation of NF-B and sensitizes human prostate
carcinoma DU145 cells to TNF-induced apoptosis. Oncogene, 21: 1759-1767,
2002.
127. Tyagi,
A., Agarwal, C. and Agarwal, R.: The cancer preventive flavonoid silibinin
causes hypophosphorylation of Rb/p107and Rb2/p130 via modulation of cell cycle
regulators in human prostate carcinoma DU145 cells. Cell Cycle, 1: 137-142, 2002.
128. Singh,
R.P., Tyagi, A.K., Zhao, J. and Agarwal, R.: Silymarin inhibits growth and
causes regression of established skin tumors in SENCAR mice via modulation of
mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis, 23:
499-510, 2002.
129. Tyagi,
A., Agarwal, C. and Agarwal, R.: Inhibition of Rb phosphorylation at serine
sites and an increase in Rb-E2F complex formation by silibinin in androgendependent human prostate carcinoma LNCaP cells: role in prostate cancer
prevention. Molecular Cancer Therapeutics, 1: 525-532, 2002.
130. Singh,
R.P., Dhanalakshmi, S., Tyagi, A.K., Chan, D.C.F., Agarwal, C. and
Agarwal, R.: Dietary feeding of silibinin inhibits advance human prostate carcinoma
growth in athymic nude mice, and increases plasma insulin-like growth factorbinding protein-3 levels. Cancer Res., 62: 3063-3069, 2002.
131. Singh,
R.P., Dhanalakshmi, S. and Agarwal, R.: Phytochemicals as cell cycle
modulators: a less toxic approach in halting human cancers. Cell Cycle, 1: 156-161,
2002.
132. Singh,
R.P. and Agarwal, R.: Flavonoid antioxidant silymarin and skin cancer.
Antioxidants & Redox Signaling, 4: 655-663, 2002.
133. Tyagi,
A., Bhatia, N., Condon, M.S., Bosland, M.C., Agarwal, C. and Agarwal, R.:
Anti-proliferative and apoptotic effects of silibinin in rat prostate cancer cells.
Prostate, 53: 211-217, 2002.
134. Jiang,
W., Zhu, Z., Bhatia, N., Agarwal, R. and Thompson, H.J.: Mechanisms of
energy restriction: effects of corticosterone on cell growth, cell cycle machinery and
apoptosis. Cancer Res., 62: 5280-5287, 2002.
135. Tyagi,
A.K., Singh, R.P., Agarwal, C., Chan, D.C.F. and Agarwal, R.: Silibinin
strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced
growth inhibition, G2-M arrest and apoptosis. Clin. Cancer Res., 8: 3512-3519,
2002. (Selected for the commentary – The Biology Behind by Robert S. DiPaola
“To arrest or not to G2-M cell cycle arrest, Clin. Cancer Res., 8: 3311-3314, 2002).
32
Rajesh Agarwal, Ph.D.
136. Agarwal,
C., Singh, R.P. and Agarwal, R.: Grape seed extract inhibits growth and
induces apoptotic death of prostate carcinoma DU145 cells via caspases activation
accompanied by dissipation of mitochondrial membrane potential and cytochrome c
release. Carcinogenesis, 23: 1869-1876, 2002.
137. Tyagi,
A., Agarwal, R. and Agarwal, C.: Grape seed extract inhibits EGF-induced
and constitutively active mitogenic signaling but activates JNK in human prostate
carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene,
22: 1302-1316, 2003.
138. Singh,
R.P., Agarwal, C. and Agarwal, R.: Inositol hexaphosphate inhibits growth,
and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells:
modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes.
Carcinogenesis, 24: 555-563, 2003.
139. Singh,
R.P. and Agarwal, R.: Tumor angiogenesis: a potential target in cancer
control by phytochemicals. Current Cancer Drug Targets, 3: 203-215, 2003.
140. Singh,
R.P. and Agarwal, R.: Prostate cancer prevention by silibinin. Current
Cancer Drug Targets, 4: 1-11, 2004.
141. Dhanalakshmi,
S., Agarwal, P., Glode, L.M. and Agarwal, R.: Silibinin sensitizes
human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth
inhibition and apoptotic death. Int. J. Cancer, 106: 699-705, 2003.
142. Sharma,
G., Singh, R.P., Chan, D.C.F. and Agarwal, R.: Silibinin induces growth
inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Res.,
23: 2649-2655, 2003.
143. Dhanalakshmi,
S., Agarwal, R. and Agarwal, C.: Inhibition of NF-kB pathway in
grape seed extract-induced apoptotic death of human prostate carcinoma DU145
cells. Int. J. Oncology, 23: 721-727, 2003.
144. Singh,
R.P., Sharma, G., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.:
Suppression of advanced human prostate tumor growth in nude mice by silibinin
feeding is associated with reduced cell proliferation, increased apoptosis, and
inhibition of angiogenesis. Cancer Epidemiology, Biomarkers & Prevention, 12:
933-939, 2003.
145. Qi,
L., Singh, R.P., Lu, Y., Agarwal, R., Harrison, G.S., Franzusoff, A. and Glode,
L.M.: Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat
glioma cell line. Cancer Biology and Therapy, 2: 526-531, 2003.
146. Agarwal,
C., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Inositol
hexaphosphate inhibits constitutive activation of NF-B in androgen-independent
human prostate carcinoma DU145 cells. Anticancer Res., 23: 3855-3862, 2003.
33
Rajesh Agarwal, Ph.D.
147. Sharma,
G., Singh, R.P. and Agarwal, R.: Growth inhibitory and apoptotic effects of
inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMPC1) cells. Int. J. Oncology, 23: 1413-1418, 2003.
148. Agarwal,
C., Singh, R.P., Dhanalakshmi, S., Tyagi, A.K., Tecklenburg, M., Sclafani,
R.A. and Agarwal, R.: Silibinin up-regulates the expression of cyclin-dependent
kinase inhibitors, and causes cell cycle arrest and apoptosis in human colon
carcinoma HT-29 cells. Oncogene, 22: 8271-8282, 2003.
149. Tyagi,
A.K., Agarwal, C., Singh, R.P., Shroyer, K.R., Glode, L.M. and Agarwal, R.:
Silibinin down-regulates survivin protein and mRNA expression and causes
caspases activation and apoptosis in human bladder transitional-cell papilloma RT4
cells. Biochem. Biophys. Res. Commun., 312: 1178-1184, 2003.
150. Dhanalakshmi,
S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Dual-efficacy of
silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in human
immortalized keratinocyte HaCaT cells. Carcinogenesis, 25: 99-106, 2004.
151. Singh,
R.P., Tyagi, A.K., Dhanalakshmi, S., Agarwal, R. and Agarwal, C.: Grape
seed extract inhibits advanced human prostate tumor growth and angiogenesis, and
up-regulates insulin-like growth factor binding protein-3. Int. J. Cancer, 108: 733740, 2004.
152. Singh,
R.P., Sharma, G., Mallikarjuna, G.U., Dhanalakshmi, S., Agarwal, C. and
Agarwal, R.: In vivo suppression of hormone-refractory prostate cancer growth by
inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and
inhibition of vascular endothelial growth factor. Clinical Cancer Res., 10: 244-250,
2004.
153. Sharma,
G., Tyagi, A.K., Singh, R.P., Chan, D.C.F. and Agarwal, R.: Synergistic
anti-cancer effects of grape seed extract and conventional cytotoxic agent
doxorubicin against human breast carcinoma cells. Breast Cancer Res. Treatment,
85: 1-12, 2004.
154. Tyagi,
A.K., Agarwal, C., Chan, D.C.F. and Agarwal, R.: Synergistic anti-cancer
effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and
carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells.
Oncology Reports, 11: 493-499, 2004.
155. Agarwal,
C., Singh, R.P., Dhanalakshmi, S. and Agarwal, R.: Anti-angiogenic
efficacy of grape seed extract in endothelial cells. Oncology Reports, 11: 681-685,
2004.
34
Rajesh Agarwal, Ph.D.
156. Dhanalakshmi,
S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Silibinin
prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a
decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in
epidermis. Carcinogenesis, 25: 1459-1465, 2004.
157. Tyagi,
A., Agarwal, C., Harrison, G., Glode, L.M. and Agarwal, R.: Silibinin causes
cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by
regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.
Carcinogenesis, 25: 1711-1720, 2004.
158. Agarwal,
C., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Inositol
Hexaphosphate Inhibits Growth, and Induces G1 Arrest and Apoptotic Death of
Androgen-dependent Human Prostate Carcinoma LNCaP Cells. Neoplasia, 6: 646659, 2004.
159. Mohan,
S., Dhanalakshmi, S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.:
Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases
activation and mitogen-activated protein kinase signaling in human epidermoid
carcinoma A431 cells. Biochem. Biophys. Res. Commun., 320: 183-189, 2004.
160. Singh,
R.P. and Agarwal, R.: A Cancer Chemopreventive Agent Silibinin, Targets
Mitogenic and Survival Signaling in Prostate Cancer. Mutation Res., 555: 21-32,
2004.
161. Mallikarjuna,
G.U., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.:
Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle
Regulators, and Mitogen-Activated Protein Kinases and Akt Signaling. Cancer Res.,
64: 6349-6356, 2004.
162. Singh,
R.P., Mallikarjuna, G.U., Sharma, G., Dhanalakshmi, S., Tyagi, A.K., Chan,
D.C.F., Agarwal, C. and Agarwal, R.: Oral Silibinin Inhibits Lung Tumor Growth in
Athymic Nude Mice and Forms a Novel Chemo-combination with Doxorubicin
Targeting NF-B-mediated Inducible Chemoresistance. Clin. Cancer Res., 10: 86418647, 2004.
163. Singh,
R.P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin strongly
inhibits growth and survival of human endothelial cells via cell cycle arrest and
down-regulation of survivin, Akt and NF-B: implications for angioprevention and
antiangiogenic therapy. Oncogene, 24: 1188-1202, 2005.
164. Kaur,
M., Agarwal, C., Singh, R.P., Guan, X., Dwivedi, C. and Agarwal, R.: Skin
cancer chemopreventive agent, -santalol, induces apoptotic death of human
epidermoid carcinoma A431 cells via caspases activation together with dissipation
of mitochondrial membrane potential and cytochrome c release. Carcinogenesis, 26:
369-380, 2005.
35
Rajesh Agarwal, Ph.D.
165. Yim,
D., Singh, R.P., Agarwal, C., Lee, S., Chi, H. and Agarwal, R.: A Novel
Anticancer Agent, Decursin, Induces G1 Arrest and Apoptosis in Human Prostate
Carcinoma DU145 Cells. Cancer Res., 65: 1035-1044, 2005.
166. Singh,
R.P., Agrawal, P., Yim, D., Agarwal, C. and Agarwal, R.: Acacetin inhibits
cell growth and cell cycle progression, and induces apoptosis in human prostate
cancer cells: structure-activity relationship with linarin and linarin acetate.
Carcinogenesis, 26: 845-854, 2005.
167. Mallikarjuna,
G.U., Dhanalakshmi, S., Singh, R.P. and Agarwal, R.: Dietary
Feeding of Silibinin Prevents Early Biomarkers of Ultraviolet B Radiation-induced
Carcinogenesis in SKH-1 Hairless Mouse Epidermis. Cancer Epidemiology
Biomarkers & Prevention, 14: 1344-1349, 2005.
168. Davis-Searles,
P.R., Nakanishi, Y., Kim, N.-C., Graf, T.N., Oberlies, N.H., Wani,
M.C., Wall, M.E., Agarwal, R. and Kroll, D.J.: Milk thistle and prostate cancer:
differential effects of pure flavonolignans from Silybum marianum on antiproliferative endpoints in human prostate carcinoma cells. Cancer Res., 65: 44484457, 2005.
169. Dhanalakshmi,
S., Agarwal, C., Singh, R.P. and Agarwal, R.: Silibinin up-regulates
DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in
mouse epithelial JB6 cells. J. Biol. Chem., 280: 20375-20383, 2005.
170. Mallikarjuna,
G.U., Dhanalakshmi, S., Mohan, S., Singh, R.P. and Agarwal, R.:
Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and
associated biological responses in SKH-1 mouse skin. Carcinogenesis Advance
Access publication April 14, 2005. Carcinogenesis, 26: 1404-1413, 2005.
171. Singh,
R.P. and Agarwal, R.: Mechanisms and preclinical efficacy of silibinin in
preventing skin cancer. Eur. J. Cancer, 41: 1969-1979, 2005.
172. Singh,
R.P. and Agarwal, R.: Prostate cancer and inositol hexaphosphate: efficacy
and mechanisms. Anticancer Res., 25: 2891-2903, 2005.
173. Tyagi,
A., Singh, R.P., Agarwal, C., Siriwardana, S., Sclafani, R.A. and Agarwal, R.:
Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C
pathway as a central mechanism for S phase arrest in human ovarian carcinoma
Ovcar-3 cells. Carcinogenesis, 26:1978-1987, 2005.
174. Varghese,
L., Agarwal, C., Tyagi, A., Singh, R.P. and Agarwal, R.: Silibinin efficacy
against human hepatocellular carcinoma. Clin. Cancer Res., 11: 8441-8448, 2005.
36
Rajesh Agarwal, Ph.D.
175. Deep,
G., Singh, R.P., Agarwal, C., Kroll, D.J. and Agarwal, R.: Silymarin and
silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human
prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan
mixture silymarin. Oncogene, 25: 1053-1069, 2006.
176. Singh,
R.P. and Agarwal, R.: Natural flavonoids targeting deregulated cell cycle
progression in cancer cells. Current Drug Targets, 7: 345-354, 2006.
177. Veluri,
R., Singh, R.P., Liu, Z., Thompson, J.A., Agarwal, R. and Agarwal, C.:
Fractionation of grape seed extract and identification of gallic acid as one of the
major active constituents causing growth inhibition and apoptotic death of DU145
human prostate carcinoma cells. Carcinogenesis, Advance Access published online
on February 10th, 2006. Carcinogenesis, 27: 1445-1453, 2006.
R. P. and Agarwal, R.: Prostate cancer prevention by silibinin – bench to
bedside. Mol. Carcinogenesis, 45: 436-442, 2006.
178. Singh,
179. Singh,
R.P., Dhanalakshmi, S., Mohan, S., Agarwal, C. and Agarwal, R.: Silibinin
inhibits UVB- and EGF-induced mitogenic and cell survival signaling involving AP-1
and NF-κB in mouse epidermal JB6 cells. Mol. Cancer Therapeutics, 5: 1145-1153,
2006.
180. Kaur,
M., Agarwal, R. and Agarwal, C.: Grape Seed Extract induces anoikis and
caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible
role of ATM-p53 activation. Mol. Cancer Therapeutics, 5: 1265-1274, 2006.
C., Valluri, H.B., Guan, X. and Agarwal, R.: Chemopreventive effects of αsantalol on UVB-induced skin cancer development. Carcinogenesis, Advance
Access published online on May 4th, 2006. Carcinogenesis, 27: 1917-1922, 2006.
181. Dwivedi,
182. Singh,
R.P., Deep, G., Chittezhath, M., Kaur, M., Dwyer-Nield, L.D., Malkinson,
A.M. and Agarwal, R.: Effect of silibinin on the growth and progression of primary
lung tumors in mice. J. Natl. Cancer Inst., 98: 845-855, 2006.
183. Tyagi,
A., Singh, R. P., Agarwal, C. and Agarwal, R.: Silibinin activates p53caspase-2 pathway and causes caspase-mediated cleavage of cip1/p21 in
apoptosis induction in bladder transitional-cell papilloma RT4 cells: an evidence for
a regulatory loop between p53 and caspase-2. Carcinogenesis, Advance Access
published online on June 15th, 2006. Carcinogenesis, 27: 2269-2280, 2006.
184. Gu,
M., Singh, R.P., Dhanalakshmi, S., Mohan, S. and Agarwal, R.: Differential
effect of silibinin on E2F transcription factors and associated biological events in
chronically ultraviolet B exposed skin versus tumors in SKH1 hairless mice. Mol.
Cancer Therapeutics. 5: 2121-2129, 2006.
37
Rajesh Agarwal, Ph.D.
185. Singh,
R. P. and Agarwal, R.: Mechanisms of action of novel agents for prostate
cancer chemoprevention. Endocrine-Related Cancer, 13: 751-778, 2006.
186. Agarwal,
R., Agarwal, C., Ichikawa, H., Singh, R.P. and Aggarwal, B.B.: Anticancer
Potential of Silymarin: From Bench to Bedside and Back. Anticancer Res., 26: 44574498, 2006.
187. Kaur,
M., Singh, R.P., Gu, M., Agarwal, R. and Agarwal, C.: Grape Seed Extract
Inhibits in Vitro and in Vivo Growth of Human Colorectal Carcinoma Cells. Clin
Cancer Res., 12: 6194-6202, 2006. This publication has had an AACR press
release entitled “Grape seed extract halts cell cycle, checking growth of colorectal
tumors in mice” dated October 18th, 2006. Also featured on Forbes and Rocky
Mountain Newspaper.
188. Agarwal,
C., Tyagi, A. and Agarwal, R.: Gallic acid causes inactivating
phosphorylation of cdc25A/C-cdc2 via ATM-Chk2 activation, leading to cell cycle
arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Mol.
Cancer Therapeutics, 5: 3294-3302, 2006.
189. Flaig,
T.W., Su, L.-J., Harrison, G., Agarwal, R. and Glodé, L.M.: Silibinin
synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human
prostate cancer cells. Int. J. Cancer, 120: 2028-2033, 2007.
190. Flaig,
T.W., Gustafson, D.L., Su, L.-J., Zirrolli, J., Crighton, F., Harrison, G.,
Pierson, A. S., Agarwal, R. and Glodé, L.M.: A Phase I and Pharmacokinetic Study
of Silybin-Phytosome in prostate cancer patients. Investigational New Drugs, 25:
139-146, 2007.
191. Kaur,
M. and Agarwal, R.: Silymarin and epithelial cancer chemoprevention: how
close we are to bedside? Toxicol. Appl. Pharmacol., 224: 350-359, 2007.
192. Kaur,
M. and Agarwal, R.: Transcription Factors: Molecular Targets for Prostate
Cancer Intervention by Phytochemicals. Current Cancer Drug Targets, 7: 355-367,
2007.
193. Singh,
R.P. and Agarwal, R.: Inducible Nitric Oxide Synthase-Vascular Endothelial
Growth Factor Axis: A Potential Target to Inhibit Tumor Angiogenesis by Dietary
Agents. Current Cancer Drug Targets, 7: 475-483, 2007.
194. Gu,
M., Singh, R.P., Dhanalakshmi, S., Agarwal, C. and Agarwal, R.: Silibinin
Inhibits Inflammatory and Angiogenic Attributes in Photocarcinogenesis in SKH-1
Hairless Mice. Cancer Res., 67: 3483-3491, 2007.
195. Agarwal,
C., Tyagi, A., Kaur, M. and Agarwal, R.: Silibinin inhibits constitutive
activation of Stat3, and causes caspase activation and apoptotic death of human
prostate carcinoma DU145 cells. Carcinogenesis, 28: 1463-1470, 2007.
38
Rajesh Agarwal, Ph.D.
196. Agarwal,
C., Veluri, R., Kaur, M., Chou, S.-C., Thompson, J.A. and Agarwal, R.:
Fractionation of high molecular weight tannins in grape seed extract and
identification of procyanidin B2-3,3’-di-O-gallate as a major active constituent
causing growth inhibition and apoptotic death of DU145 human prostate carcinoma
cells. Carcinogenesis, 28: 1478-1484, 2007.
197. Deep,
G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B and isosilybin A
inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer
LNCaP and 22Rv1 cells. Carcinogenesis, 28: 1533-1542, 2007.
198. Raina,
K., Singh, R.P., Agarwal, R. and Agarwal, C.: Oral Grape Seed Extract
Inhibits Prostate Tumor Growth and Progression in TRAMP Mice. Cancer Research,
67: 5976-5982, 2007.
199. Deep,
G. and Agarwal, R.: Chemopreventive Efficacy of Silymarin in Skin and
Prostate Cancer. Integrative Cancer Therapies, 6: 130-145, 2007.
200. Raina,
K. and Agarwal, R.: Combinatorial Strategies for Cancer Eradication by
Silibinin and Cytotoxic Agents: Efficacy and Mechanisms. Acta Pharmacologica
Sinica, 28: 1466-1475, 2007.
201. Velmurugan,
B., Agarwal, R. and Singh, R.P.: Role of Bioactive Natural
Compounds in Cancer Control. Phytopharmacology and Therapeutic Values III of
the Series Recent Progress in Medicinal Plants, Vol. 21, 383-412, 2007.
202. Roy,
S., Kaur, M., Agarwal, C., Tecklenburg, M., Sclafani, R.A. and Agarwal, R.:
P21 and p27 induction by silibinin is essential for its cell cycle arrest effect in
prostate carcinoma cells. Mol. Cancer Therapeutics, 6: 2696-2707, 2007.
203. Tyagi,
A., Raina, K., Singh, R.P., Gu, M., Agarwal, C., Harrison, G., Glodé, L.M. and
Agarwal, R.: Chemopreventive Effects of Silymarin and Silibinin on N-Butyl-N-(4hydroxybutyl) Nitrosamine-induced Urinary Bladder Carcinogenesis in Male ICR
Mice. Mol. Cancer Therapeutics, 6: 3248-3255, 2007.
204. Raina,
K., Blouin, M.J., Singh, R.P., Majeed, N., Deep, G., Varghese, L., Glodé,
L.M., Greenberg, N.M., Hwang, D., Cohen, P., Pollak, M.N. and Agarwal, R.:
Dietary Feeding of Silibinin Inhibits Prostate Tumor Growth and Progression in
Transgenic Adenocarcinoma of the Mouse Prostate Model. Cancer Research, 67:
11083-11091, 2007.
205. Singh,
R.P., Deep, G., Blouin, M.J., Pollak, M.N. and Agarwal, R.: Silibinin
suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.
Carcinogenesis, 28: 2567-2574, 2007.
39
Rajesh Agarwal, Ph.D.
206. Graf,
T.N., Wani, M.C., Agarwal, R., Kroll, D.J. and Oberlies, N.H.: Gram-scale
purification of flavonolignan diastereoisomers from Silybum marianum (milk thistle)
in support of preclinical in vivo studies for prostate cancer chemoprevention. Planta
Medica, Adv. Access Published Online October 18th, 2007.
207. Singh,
R.P., Tyagi, A., Sharma, G., Mohan, S. and Agarwal, R.: Oral Silibinin
Inhibits In Vivo Human Bladder Tumor Xenograft Growth Involving Down-Regulation
of Survivin. Clin. Cancer Res., 14: 300-308, 2008.
208. Anwar,
A., Gu, M., Brady, S., Qamar, L., Behbakht, K., Shellman, G.Y., Agarwal,
R., Norris, D.A., Horwitz, L.D. and Fujita. M.: Photoprotective Effects of Bucillamine
against UV-Induced skin Damage in a SKH-1 Hairless Mouse Model.
Photochemistry Photobiology, In Press, 2008.
209. Deep,
G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Identifying the differential
effects of silymarin constituents on cell growth and cell cycle regulatory molecules in
human prostate cancer cells. Int. J. Cancer, In Press, 2008.
210. Singh,
R.P., Gu, M. and Agarwal, R.: Silibinin Inhibits Colorectal Cancer Growth by
Inhibiting Tumor Cell Proliferation and Angiogenesis. Cancer Res., In Press, 2008.
211. Raina,
K., Rajamanickam, S., Singh, R.P. and Agarwal, R.: Chemopreventive
Efficacy of Inositol Hexaphosphate against Prostate Tumor Growth and Progression
in TRAMP Mice. Clin. Cancer Res., In Press, 2008.
212. Raina,
K., Rajamanickam, S., Deep, G., Singh, M., Agarwal, R. and Agarwal, C.:
Chemopreventive Effects of Oral Gallic Acid Feeding on Tumor Growth and
Progression in TRAMP Mice. Mol. Cancer Therapeutics, Accepted pending minor
revisions, 2008.
213. Singh,
R.P. and Agarwal, R.: Cosmeceutical Benefits of Silibinin. Clinics in
Dermatology. In Press, 2008.
M., Agarwal, R. and Agarwal, C.: Grape Seed Extract – a write up. Cancer
Enzyclopedia. In Press, 2008.
214. Kaur,
215. Tyagi,
A., Sharma, Y., Agarwal, C. and Agarwal, R.: Silibinin Impairs Constitutively
Active TGF-EGFR Autocrine Loop in Advanced Human Prostate Carcinoma Cells.
Pharmaceutical Research, In Press, 2008.
216. Deep,
G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B causes Androgen
Receptor Degradation in Human Prostate Carcinoma LNCaP and 22Rv1 Cells via
PI3K-Akt-Mdm2-Mediated Pathway. Oncogene, In Press, 2008.
217. Ramasamy,
K. and Agarwal, R.: Multitargeted therapy of cancer by silymarin.
Submitted, 2008.
40
Rajesh Agarwal, Ph.D.
218. Kaur,
M., Deep, G. and Agarwal, R.: Silibinin in skin health: Efficacy and
mechanism of action. In Blair, R.M. and Tabor, A. Eds. "Nutritional Cosmetics:
Beauty from Within" to be published by William Andrew Publishing, In Press, 2008.
219. Chittezhath,
M., Deep, G., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin
inhibits cytokine-induced STATs, MAPKs, NF-κB and AP-1 activation, and downregulates HIF-1 and iNOS in human lung epithelial carcinoma A549 cells.
Submitted, 2008
220. Singh,
R.P., Raina, K., Sharma, G. and Agarwal, R.: Silibinin Alters Angiogenesis
and Epithelial-Mesenchymal-Transition to Suppress Prostate Tumor Progression
and Metastasis in Mice. Submitted, 2008.
41
Rajesh Agarwal, Ph.D.
BOOK CHAPTERS
1. Agarwal, R. and Mukhtar, H.: Cutaneous chemical carcinogenesis. In
Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 371-387, 1991.
2.
Mukhtar, H., Agarwal, R. and Bickers, D.R.: Cutaneous metabolism of xenobiotics
and steroid hormones. In Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press,
pp. 89-109, 1991.
3.
Raza, H., Agarwal, R. and Mukhtar, H.: Cutaneous glutathione S-transferases. In
Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 131-137, 1991.
4.
Athar, M., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Role of reactive oxygen
species in skin. In Pharmacology of the Skin, Mukhtar, H. (ed), CRC Press, pp. 269279, 1991.
5.
Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Cancer chemoprevention by green tea
polyphenols. Proceedings of the International Symposium on Tea Sciences,
Yaminishi, T. and Tomita, I. (eds), pp. 12-16, 1992.
6.
Mukhtar, H. and Agarwal, R.: Cytochrome P-450-dependent metabolism of drugs
and carcinogens in skin. In Health Risk Assessment: Dermal and Inhalation
Exposure and Absorption of Toxicants, Wang, R.G.M., Knaak, J.B. and Maibach,
H.I. (eds), CRC Press, pp. 47-61, 1992.
7.
Agarwal, R. and Mukhtar, H.: Chemical carcinogenesis in skin: causation,
mechanism and role of oncogenes. In Health Risk Assessment: Dermal and
Inhalation Exposure and Absorption of Toxicants, Wang, R.G.M., Knaak, J.B. and
Maibach, H.I. (eds), CRC Press, pp. 291-305, 1992.
8.
Agarwal, R. and Mukhtar, H.: Oxidative stress in skin chemical carcinogenesis. In
Oxidative Stress in Dermatology, Fuchs, J. and Packer, L. (eds), Marcel Dekker,
Inc., pp. 207-241, 1993.
9.
Mukhtar, H., Agarwal, R. and Katiyar, S.K.: Anticarcinogenic and antiinflammatory
effects of green tea in murine skin, Proceedings of the 2 nd International Symposium
on Green Tea, Seoul, Korea, pp. 33-55, 1993.
10.
Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Introduction: Sources, occurrence,
nomenclature and carcinogenicity of polycyclic aromatic hydrocarbons. In
Handbook of Chromatography: Liquid chromatography of polycyclic aromatic
hydrocarbons, Rathore, H.S. (ed), CRC Press, pp. 1-17, 1993.
11.
Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Cancer chemoprevention by green tea
components. In Advances in Experimental Medicine and Biology: Diet and Cancer:
42
Rajesh Agarwal, Ph.D.
Markers, Prevention and Treatment, Jacobs, M.M. (ed), Plenum Press, Volume 354,
pp. 121-132, 1993.
12.
Mukhtar, H., Mercurio, M.G. and Agarwal, R.: Murine skin carcinogenesis:
Relevance to humans. In Skin Cancer: Mechanism and Human Relevance,
Mukhtar, H. (ed), CRC Press, pp. 3-8, 1994.
13.
Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras p21 post-translational processing: An
overview and studies in skin cancer. In Skin Cancer: Mechanism and Human
Relevance, Mukhtar, H. (ed), CRC Press, pp. 293-304, 1994.
14.
Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Skin cancer chemoprevention by
naturally occurring polyphenols. In Skin Cancer: Mechanism and Human
Relevance, Mukhtar, H. (ed), CRC Press, pp. 391-399, 1994.
15.
Agarwal, R. and Mukhtar, H.: Cancer chemoprevention by polyphenols in green tea
and artichoke. In Advances in Experimental Medicine and Biology: Dietary
Phytochemicals in Cancer Prevention and Treatment, Plenum Press, Volume 401,
pp. 35-50, 1996.
16.
Lahiri, M., Mukhtar, H. and Agarwal, R.: Reactive intermediates and skin cancer. In
Carcinogenicity: Testing, Predicting, and Interpreting Chemical Effects. Kitchin, K.T.
(Ed), Marcel Dekker, Inc., 679-714, 1999.
17.
Singh, R.P. and Agarwal, R.: SENCAR mouse skin tumorigenesis model. In Tumor
Models in Cancer Research. Teicher, B.A. (Ed), The Humana Press Inc, Totowa,
NJ, 2001, pp. 359-380.
CONFERENCES/SEMINARS/SYMPOSIUMS
1. Agarwal, R., Satsangi, R.K., Shukla, M.K., and Chaudhary, C.: Synthesis and CNS
activity of 4-aryl-1-(p-(3’,4’,5’-tri-substituted benzamido)-benzoyl)-piperazines. Paper
presented at XIII Annual Meeting of Indian Pharmacological Society (India)
September 1980.
2.
Agarwal, R., Satsangi, R.K., and Shukla, M.K.: Synthesis and CNS activity of 3-(4(1’-piperazinamido-4- aryl(methyl)- anilinomethyl)- benzoxazolin- 2-ones/ thiones.
Paper presented at Convention of Chemists (India), December, 1980.
3.
Agarwal, R.: Chemistry and CNS activity of 1-(4-methyl coumarin-7yl)-oxyacetyl-3methyl-4-(substituted phenyl) hydrazono/azo-pyrazolin-5-ones. Paper presented at
Convention of Chemists (India), December, 1981.
4.
Chaudhary, C., Agarwal, R., and Misra, V.S.: Synthesis of 1-(4-morpholino-phenyl)2-aryl-4-(3,4-disubstituted benzylidene)-imidazolin-5-ones as CNS active agents.
Paper presented at Convention of Chemists (India), December, 1981.
43
Rajesh Agarwal, Ph.D.
5.
Singh, C., Agarwal, R., and Misra, V.S.: Synthesis of 1-(p-substituted phenyl)-2oxo-3(o-chlorophenoxy)-4-(2-arylindol-3yl)-azetidines. Paper presented at
Convention of Chemists (India), December, 1981.
6.
Agarwal, R., Kumar, S., and Mehrotra, N.K.: Fractionation of Jute Batching Oil for
identifying tumour inducing components. Paper presented at IIIrd Annual
Convention of Indian Association for Cancer Research, March, 1984.
7.
Agarwal, R., Gupta, K.P., Kumar, S., and Mehrotra, N.K.: Ability of fresh and used
industrial crude oil to induce AHH in mo:use epidermis. Paper presented at IVth
Annual Conference of Society of Toxicology (India), November, 1984.
8.
Mohan, R.R., Agarwal, R., and Misra, V.S.: Synthesis of some newer quinazolines
as pharmacologically active agents. Paper presented at 72nd session of Indian
Science Congress Association, January, 1985.
9.
Mohan, R.R., Agarwal, C., Agarwal, R., and Misra, V.S.: Indophenazines: A new
class of CNS and anti-inflammatory agents. Paper presented at National
Symposium of Newer Trends in Synthetic Heterocyclic Chemistry, February, 1985.
10.
Agarwal, R., Kumar, S., Shukla, Y., and Mehrotra, N.K.: A study of tumour initiating
potential of JBO fractions in mouse skin. Paper presented at IVth Annual
Convention of Indian Association for Cancer Research, February, 1985.
11.
Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Carcinogenic effect of JBOP and its fractions over mouse skin. Paper presented at Vth Annual Conference of
Society of Toxicology (India), November, 1985.
12.
Agarwal, R., Kumar, S., Antony, M., and Mehrotra, N.K.: Chemical and biochemical
basis of tumour promoting ability of JBO. Paper presented at Vth Annual
Conference of Society of Toxicology (India), November, 1985.
13.
Agarwal, R., Bhargava, S.K., Kidwai, M.M., Mehrotra, N.K., and Lal, M.M.:
Estimation of BaP in ambient air of different areas of Lucknow city. Paper presented
at National Symposium of chemical carcinogenesis and carcinogens in the
environment. December, 1985.
14.
Agarwal, R., and Kumar, S.: Protein quality of some vigna unguiculata samples
growing in Manipur. Paper presented at Annual Conference of India Council of
Chemists, December, 1987.
15.
Agarwal, R., Shukla, Y., Kumar, S., and Mehrotra, N.K.: Tumour initiating potential
of JBO-P and its fractions over mouse skin. Paper presented at Vllth Annual
Convention of Indian Association for Cancer Research, February, 1988.
44
Rajesh Agarwal, Ph.D.
16.
Agarwal, R., and Burke, M.: Nucleotide and temperature-induced changes in the
flexibility between SH1 (cys-707) and cys-522 in myosin subfragment 1 probed by
crosslinking. FASEB J., 4, A1214, 1990.
17.
Agarwal, R., Raza, H., and Mukhtar, H.: Lipoxygenase catalyzed metabolism of the
skin carcinogen BaP in rodent and human epidermis. J. Invest. Dermatol., 94, 502,
1990.
18.
Mukhtar, H., Athar, M., Agarwal, R., Elmets, C.A., and Bickers, D.R.:
Chloroaluminum phthalocyanine tetrasulfonate (ALPCTS) photodynamic therapy
(PDT) of cutaneous tumors. Photochem. Photobiol., 51 (Suppl), 74S, 1990.
19. Agarwal, R. and Mukhtar, H.: Lipoxygenase catalyzed metabolism of
benzo(a)pyrene and benzo(a)pyrene-7,8-diol in human skin. Toxicologist, 11, 346,
1991.
20.
Mukhtar, H., Agarwal, R., Raza, H. and Bickers, D.R.: Glutathione S-transferasedependent conjugation of leukotriene A4 to leukotriene C4 in rodent and human skin.
FASEB J., 5, A1205, 1991.
21.
Agarwal, R., Tafel, J. and Mukhtar, H.: Role of singlet oxygen in in vivo and in vitro
photodestruction of microsomal membranes by chloroaluminum phthalocyanine
tetrasulfonate. FASEB J., 5, A1563, 1991.
22.
Zaidi, S.I.A., Agarwal, R., Rihter, B.D., Kenney, M.E., Oleinick, N.L. and Mukhtar,
H.: Photoenhancement of lipid peroxidation in human erythrocyte membranes by
new silicon phthalocyanines. FASEB J., 5, A1563, 1991.
23.
Agarwal, R., Elmets, C.A., Bickers, D.R. and Mukhtar, H.: Photodynamic therapy of
ultraviolet B radiation-induced murine skin tumors by photofrin-II and
chloroaluminum phthalocyanine tetrasulfonate. J. Invest. Dermatol., 96, 589 1991.
24.
Zaidi, S.I.A., Evans, B.N., Raza, H., Agarwal, R., Ahmad, H., Awasthi, Y.C. and
Mukhtar, H.: Altered expression of glutathione S-transferase isozymes in murine and
human skin tumors. J. Invest. Dermatol., 96, 599, 1991.
25.
Mukhtar, H., Agarwal, R., Wang, Z.Y. and Bickers, D.R.: Antimutagenic and antitumorigenic activities of nordihydroguaiaretic acid. Proc. Amer. Assoc. Cancer Res.,
32, 147, 1991.
26.
Agarwal, R. and Mukhtar, H.: Metabolism of benzo(a)pyrene and benzo(a)pyrene
7,8-dihydrodiol catalyzed by human rodent epidermal lipoxygenase. Proc. Amer.
Assoc. Cancer Res., 32, 117, 1991.
45
Rajesh Agarwal, Ph.D.
27.
Mukhtar, H., Zaidi, S.I.A., Agarwal, R., Eichler, G., Rihter, B., Kenney, M.E., Clay,
M.D., Oleinick, N.L. and Bickers, D.R.: Photodynamic effects of silicon
phthalocyanine in Chinese hamster V79 cells and human erythrocyte membranes.
Photochem. Photobiol., 53, 93S, 1991.
28.
Burke, M. and Agarwal, R.: Substructure of myosin subfragment 1 by photocrosslinking. Location of the cross-link formed in the presence of MgADP from SH1 to the
50-kDa domain. Proc. 15th Int. Congress of Biochem., Jerusalem, Israel, August,
1991, p 163.
29.
Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against skin tumor promotion
in SENCAR mice by green tea polyphenols. 2nd Annual Meeting Am. Inst. Cancer
Res., Washington, DC, October, 1991.
30.
Agarwal, R., Jugert, F.K., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Multiple
cytochrome P-450 isozymes in murine skin: induction by pyridine. FASEB J., 6,
A1567, 1992.
31.
Jugert, F.K., Agarwal, R., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Induction of
multiple cytochrome P-450 isoenzymes in murine skin by dexamethasone. FASEB
J., 6, A1567, 1992.
32.
Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promoter-caused
induction of epidermal ornithine decarboxylase (ODC) and skin tumor promotion in
SENCAR mice by green tea polyphenols. FASEB J., 6, A1495, 1992.
33.
Agarwal, R., Katiyar, S.K., Zaidi, S.I.A. and Mukhtar, H.: Inhibition of tumor
promoter-caused epidermal ornithine decarboxylase induction by polyphenolic
fraction isolated from green tea. Proc. Amer. Assoc. Cancer Res., 33:168, 1992.
34.
Katiyar, S.K., Agarwal, R., Wang, Z.Y. and Mukhtar, H.: Protection against 12-Otetradecanoylphorbol-13-acetate-caused tumor promotion in SENCAR mice by
polyphenolic fraction from green tea. Proc. Amer. Assoc. Cancer Res., 33:168,
1992.
35.
Zaidi, S.I.A., Agarwal, R. and Mukhtar, H.: Expression of glutathione S-transferases
in murine and human skin tumors. Proc. Amer. Assoc. Cancer Res., 33:11, 1992.
36.
Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of tumor promotion in murine
skin by green tea polyphenols. J. Invest. Derm., 98, 663, 1992.
37.
Jugert, F.K., Agarwal, R., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Evidence for
the occurrence of multiple cytochrome P-450 isozymes in murine skin: induction by
dexamethasone. J. Invest. Derm., 98, 652, 1992.
46
Rajesh Agarwal, Ph.D.
38.
Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Mechanism of
photodynamic effects of chloroaluminum phthalocyanine. J. Invest. Derm., 98, 657,
1992.
39.
Agarwal, R., Jugert, F.K., Merk, H.F., Bickers, D.R. and Mukhtar, H.: Induction of
cytochrome P-450 isozymes 1A, 2B and 3A in murine skin by pyridine. J. Invest.
Derm., 98, 652, 1992.
40.
Agarwal, R., Raza, H., Bickers, D.R. and Mukhtar, H.: Biotransformation of
leukotriene A4 to leukotriene C4 by affinity purified glutathione s-transferase from rat
skin. Skin Pharmacol., 5, 193, 1992.
41.
Jugert, F.K., Agarwal, R., Frankenberg, S., Junginger, H., Bickers, D.R., Mukhtar,
H. and Merk, H.F.: Multiple inducible cytochrome p450 isozymes in human
epidermal keratinocytes. Skin Pharmacol., 5, 197, 1992.
42.
Jugert, F.K., Agarwal, R., Bickers, D.R., Merk, H.F. and Mukhtar, H.: Induction of
cytochrome P450 subfamilies 1A, 2B, 2E and 3A in murine skin by dexamethasone.
Skin Pharmacol., 5, 198, 1992.
43.
Katiyar, S.K., Agarwal, R., Wood, G.S. and Mukhtar, H.: Skin cancer
chemoprevention by green tea polyphenols. Skin Pharmacol., 5, 198, 1992.
44.
Studer, J.A., Jugert, F.K., Fleming, T.E., Elmets, C.A., Bik, D.P., Agarwal, R. and
Mukhtar, H.: Cytochrome P4501A1-dependent metabolism of skin carcinogen
benzo(a)pyrene in human langerhans cells. Skin Pharmacol., 5, 205, 1992.
45.
Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Photodynamic therapy of
murine skin tumors. Skin Pharmacol., 5, 207, 1992.
46.
Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of skin tumor promotion by
green tea polyphenols: mechanistic studies. Environmental Skin Cancer:
Mechanisms, Models and Human Relevance, 1992.
47.
Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Farnesyltransferase activity
and Ha-ras p21 processing during skin tumorigenesis. Environmental Skin Cancer:
Mechanisms, Models and Human Relevance, 1992.
48.
Zaidi, S.I.A., Agarwal, R., Bickers, D.R. and Mukhtar, H.: First and second
generation photosensitizer-based photodynamic therapy of murine skin tumors.
Environmental Skin Cancer: Mechanisms, Models and Human Relevance, 1992.
49.
Jugert, F.K., Agarwal, R., Mukhtar, H. and Merk, H.F.: Induction of cytochrome
P450 subfamilies 1A, 2B, 2E and 3A in murine skin by dexamethasone. 13 th
European Workshop on Drug Metabolism, European Soc. Biochem. Pharmacol.,
1992.
47
Rajesh Agarwal, Ph.D.
50.
Studer, J.A., Agarwal, R., Jugert, F.K., Fleming, T.E., Mukhtar, H. and Elmets, C.A.:
Cytochrome P4501A1-dependent metabolism of the skin carcinogen
benzo(a)pyrene in human langerhans cells. Central Regional Meeting, Soc. Invest.
Dermatol., 1992.
51.
Agarwal, R., Khan, S.G., Bickers, D.R. and Mukhtar, H.: Processing of
overexpressed Ha-ras oncoprotein p21 in chemical carcinogen-induced tumors in
SENCAR mouse skin. J. Invest. Dermatol., 100:601, 1993.
52.
Katiyar, S.K., Agarwal, R., Bickers, D.R. and Mukhtar, H.: Chemopreventive effects
of green tea against stage I and stage II tumor promotion and malignant conversion
in SENCAR mouse skin. J. Invest. Dermatol., 100:603, 1993.
53.
Mukhtar, H., Katiyar, S.K., Agarwal, R. and Bickers, D.R.: Inhibition of ultraviolet B
radiation-induced inflammatory responses in SKH-1 hairless mice by a polyphenolic
fraction isolated from green tea. J. Invest. Dermatol., 100:600, 1993.
54.
Khan, S.G., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Farnesylation of Ha-ras
p21 in ultraviolet B radiation-induced tumors in SKH-1 hairless mice. J. Invest.
Dermatol., 100:599, 1993.
55.
Agarwal, R., Khan, S.G. and Mukhtar, H.: Ha-ras processing during cutaneous
chemical carcinogenesis. Proc. Am. Assoc. Cancer Res., 34:526, 1993.
56.
Khan, S.G., Mukhtar, H. and Agarwal, R.: Farnesyltransferase activity in ultraviolet
B (UVB)-induced skin tumors in SKH-1 hairless mice. Proc. Am. Assoc. Cancer
Res., 34:526, 1993.
57.
Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against diethylnitrosamine
(DEN) and benzo()pyrene (BP)-induced forestomach and lung tumorigenesis in A/J
mice by green tea. Proc. Am. Assoc. Cancer Res., 34:555, 1993.
58.
Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against malignant conversion
of mouse skin papillomas to carcinomas by green tea polyphenols. Proc. Am.
Assoc. Cancer Res., 34:555, 1993.
59.
Agarwal, R., Katiyar, S.K., Khan, S.G. and Mukhtar, H.: Inhibition of ultraviolet B
radiation (UVB)-induced changes in the skin of SKH-1 hairless mice by green tea
polyphenols. Photochem. Photobiol., 57:24S, 1993.
60.
Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protection against tumor promoterinduced inflammation in murine skin by green tea polyphenols. 2 nd Tricontinental
Meeting of JSID, SID and ESDR, Japan, 1992. J. Invest. Dermatol., 101:393, 1993.
48
Rajesh Agarwal, Ph.D.
61.
Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras p21 farnesylation in ultraviolet
radiation-induced tumors in murine skin. 2nd Tricontinental Meeting of JSID, SID
and ESDR, Japan, 1992. J. Invest. Dermatol., 101:394, 1993.
62.
Mukhtar, H., Katiyar, S.K. and Agarwal, R.: Protective effects of green tea against
12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B radiation-induced
inflammation in murine skin. Skin Pharmacol., Abstracts:11, 1993.
63.
Agarwal, R., Khan, S.G. and Mukhtar, H.: Ras protein p21 processing in ultraviolet
B radiation-induced tumorigenesis in the skin of SKH-1 hairless mice. Skin
Pharmacol., Abstracts:1, 1993.
64.
Khan, S.G., Saxena, R., Mukhtar, H. and Agarwal, R.: ras p21 processing
modulates protein kinase C (PKC) isozymes and ornithine decarboxylase (ODC)
transcripts: possible role in tumor growth. Proc. Am. Assoc. Cancer Res., 35:616,
1994.
65.
Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Protection against diethylnitrosamine
(DEN)- and benzo(a)pyrene (BP)-induced forestomach and pulmonary neoplasia in
A/J mice by limited oral intubation of green tea polyphenols. Proc. Am. Assoc.
Cancer Res., 35:626, 1994.
66.
Agarwal, R., Katiyar, S.K., Lundgren, D.W. and Mukhtar, H.: Inhibition of 12-Otetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity
and mRNA in SENCAR mice by silymarin. Proc. Am. Assoc. Cancer Res., 35:626,
1994.
67.
Khan, S.G., Saxena, R., Bickers, D.R., Mukhtar, H. and Agarwal, R.: Ras p21 posttranslational processing with membrane localization modulates expression and
growth. J. Invest. Dermatol., 102:548, 1994.
68.
Jugert, F.K., Agarwal, R., Mukhtar, H., Bickers, D.R. and Merk, H.F.:
Dexamethasone and cyclosporin A inducible cytochrome P450 3A in murine and
human skin. J. Invest. Dermatol., 102:647, 1994.
69.
Katiyar, S.K., Agarwal, R. and Mukhtar, H.: Inhibition of lipid peroxidation in mouse
epidermal microsomes by epicatechin derivatives from green tea. J. Invest.
Dermatol., 102:652, 1994.
70.
Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Inhibitory effect of silymarin, an antihepatotoxic flavonoid, on tumor promoter-induced epidermal ornithine
decarboxylase activity and mRNA in SENCAR mice. J. Invest. Dermatol., 102:653,
1994.
49
Rajesh Agarwal, Ph.D.
71.
Dummer, R., Siddiqui, J., Khan, S.G., Haffner, A.C., Rupp, C., Bickers, D.R.,
Agarwal, R. and Mukhtar, H.: Human basal cell carcinomas frequently express the
gene for farnesyltransferase beta subunit. J. Invest. Dermatol., 102:653, 1994.
72.
Dummer, R., Siddiqui, J., Khan, S.G., Haffner, A.C., Rupp, C., Bickers, D.R.,
Agarwal, R. and Mukhtar, H.: Increased farnesylprotein transferase activity in
human basal cell carcinomas is associated with beta FTase subunit expression. J.
Invest. Dermatol., 103:411, 1994.
73.
Mukhtar, H., Agarwal, R. and Katiyar, S.K.: Inhibition of mouse skin tumor
promotion by ethanol extract of ginger root. Proc. Am. Assoc. Cancer Res., 36:594,
1995.
74.
Katiyar, S.K., Agarwal, R., Korman, N.J., Rupp, C.O. and Mukhtar, H.: Inhibition of
tumor promoter-caused induction of interleukin-1 (IL-1)-alpha, tumor necrosis factor
(TNF)-alpha, and ornithine decarboxylase (ODC) gene expression in SENCAR
mouse skin by tea polyphenols. Proc. Am. Assoc. Cancer Res., 36:594, 1995.
75.
Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against tumor promotion in
mouse skin by silymarin. Proc. Am. Assoc. Cancer Res., 36:593, 1995.
76.
Mohan, R.R., Khan, S.G., Agarwal, R. and Mukhtar, H.: Testosterone induces
ornithine decarboxylase (ODC) activity and mRNA expression in human prostate
carcinoma cell line LNCaP: inhibition by green tea. Proc. Am. Assoc. Cancer Res.,
36:274, 1995.
77.
Khan, S.G., Dummer, R., Siddiqui, J., Agarwal, R. and Mukhtar, H.:
Farnesyltransferase (FTase) activity and gene expression of its  and  subunits in
human skin basal cell carcinomas (BCCs). Proc. Am. Assoc. Cancer Res., 36:527,
1995.
78.
Mukhtar, H., Agarwal, R., Korman, N.J., Rupp, C.O. and Katiyar, S.K.: Inhibition of
tumor promoter-caused induction of epidermal interleukin-1-alpha, tumor necrosis
factor-alpha, and ornithine decarboxylase mRNA expression in SENCAR mouse by
green tea polyphenols. J. Invest. Dermatol., 104:575, 1995.
79.
Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Protection against
ultraviolet B radiation-induced local and systemic suppression of contact
hypersensitivity in mice by green tea polyphenols. J. Invest. Dermatol., 104:690,
1995.
80.
Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protective effects of silymarin against
ultraviolet B radiation-induced tumorigenesis in SKH-1 hairless mouse skin. J.
Invest. Dermatol., 104:635, 1995.
50
Rajesh Agarwal, Ph.D.
81.
Mohan, R.R., Katiyar, S.K., Mukhtar, H. and Agarwal, R.: Protective effects of
retinoic acid against tumor promotion and progression in low- and high-risk protocols
of mouse skin carcinogenesis. J. Invest. Dermatol., 104:574, 1995.
82.
Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against photocarcinogenesis
in SKH-1 hairless mice by silymarin. Photochem. Photobiol., 61s:14s, 1995.
83.
Mukhtar, H., Korman, N.J., Mohan, R.R., Jawed, S., Zaim, M.T. and Agarwal, R.:
Phthalocyanine-photodynamic therapy of murine skin tumors: Apoptosis is an early
event during tumor shrinkage. Photochem. Photobiol., 61s:41s, 1995.
84.
Katiyar, S.K., Elmets, C.A., Agarwal, R. and Mukhtar, H.: Polyphenols from green
tea inhibit UVB-caused immune suppression and IL-1
C3H/HeN mouse skin. Presented at Photocarcinogenesis: Mechanisms, Models
and Human Health Implications, October 1995, Washington, D.C. Photodermatol.
Photoimmunol. Photomed., 11:234, 1995.
85.
Agarwal, R., Katiyar, S.K. and Mukhtar, H.: Protection against photocarcinogenesis
by silymarin. Presented at Photocarcinogenesis: Mechanisms, Models and Human
Health Implications, October 1995, Washington, D.C. Photodermatol.
Photoimmunol. Photomed., 11:233, 1995.
86.
Mohan, R.R., Khan, S.G., Katiyar, S.K., Wood, G.S., Bickers, D.R., Mukhtar, H. and
Agarwal, R.: Ras oncogene mutations are rare event in ultraviolet B radiationinduced tumorigenesis in mouse skin. Presented at Photocarcinogenesis:
Mechanisms, Models and Human Health Implications, October 1995, Washington,
D.C. Photodermatol. Photoimmunol. Photomed., 11:230, 1995.
87.
Lahiri, M., Agarwal, R. and Mukhtar, H.: 32P postlabelling detection of
photoproducts in the epidermis of SKH-1 hairless mice exposed to ultraviolet B
radiation. Presented at Photocarcinogenesis: Mechanisms, Models and Human
Health Implications, October 1995, Washington, D.C. Photodermatol.
Photoimmunol. Photomed., 11:226, 1995.
88.
Agarwal, R., Lahiri, M., Mohan, R.R. and Mukhtar, H.: Stage specific anti-tumor
promoting potential of silymarin in mouse skin. Proc. Am. Assoc. Cancer Res.,
37:278, 1996.
89.
Mukhtar, H., Mohan, R.R., Bostwick, D.G., Amini, S.G. and Agarwal, R.:
Significantly higher ornithine decarboxylase (ODC) activity in human prostate cancer
than in normal tissue. Proc. Am. Assoc. Cancer Res., 37:244, 1996.
51
Rajesh Agarwal, Ph.D.
90.
Singh, S.V., Mohan, R.R., Agarwal, R., Benson, P.J., Rudy, M.A., Hu, X., Xia, H.,
Mack, L.M., Mukhtar, H., Gupta, V., Katoh, A. and Zaren, H.A.: Inhibition of H-ras
oncogene transformed tumor cell growth in vivo by diallyl disulfide is associated with
inhibition of HMG-Co A reductase activity and ras p21 membrane localization. Proc.
Am. Assoc. Cancer Res., 37:391, 1996.
91.
Agarwal, R., Lahiri, M., Mohan, R.R. and Mukhtar, H.: Anti-tumor promoting
potential of silymarin against both phorbol and nonphorbol ester type tumor
promoter-caused promotion in SENCAR mouse skin. J. Invest. Dermatol., 106:856,
1996.
92.
Lahiri, M., Agarwal, R. and Mukhtar, H.: 32P postlabelling assay: a sensitive tool for
detection of ultraviolet B radiation-induced DNA lesions. J. Invest. Dermatol.,
106:857, 1996.
93.
Katiyar, S.K., Mukhtar, H. and Agarwal, R.: Exceptionally high preventive activity of
silymarin against photocarcinogenesis in mouse skin. Experimental Skin
Carcinogenesis Conference, Smithville, TX, October, 1996.
94.
Lahiri, M., Agarwal, R. and Mukhtar, H.: Beta-naphthoflavone and 22,3,7,8tetrachlorobenzo-p-dioxin inducible cytochrome P450 1B1 in mouse epidermis. Soc.
Toxicol., 1997.
95.
Agarwal, R., Mohan, R.R., Khan, S.G. and Mukhtar, H.: Bifonazole, an anti-fungal
imidazole, inhibits HMG-CoA reductase followed by ras p21 farnesylation leading to
a selective growth inhibition of ras transformed cells. Proc. Am. Assoc. Cancer Res.,
38:96, 1997.
96.
Zi, X., Feyes, D.K., Mukhtar, H. and Agarwal, R.: Anti-carcinogenic effect of a
polyphenolic antioxidant silymarin in breast cancer cells MDA-MB468: a p53independent induction of WAF1/Cip1/p21 and G1 arrest. Proc. Am. Assoc. Cancer
Res., 38:217, 1997.
97.
Gali, H., Ahmad, N., Jawed, S., Mukhtar, H. and Agarwal, R.: Inhibition of epidermal
growth factor receptor (EGFr) tyrosine kinase activity by silymarin, a polyphenolic
antioxidant and potent cancer chemopreventive agent. Proc. Am. Assoc. Cancer
Res., 38:263, 1997.
98.
Ahmad, N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: P53-independent induction
of WAF1/Cip1/p21 regulates the cell cycle mediated apoptosis during photodynamic
therapy in human epidermoid carcinoma cells A431. Proc. Am. Assoc. Cancer Res.,
38:377, 1997.
99.
Mukhtar, H., Ahmad, N., Feyes, D.K. and Agarwal, R.: Green tea polyphenols
induce apoptosis and alter the progression of cell cycle in human epidermoid
carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 38:580, 1997.
52
Rajesh Agarwal, Ph.D.
100. Agarwal,
R., Ahmad, N., Javed, S. and Mukhtar, H.: Silymarin, a polyphenolic
antioxidant, exerts its anti-tumor promoting effect by inhibiting epidermal growth
factor receptor tyrosine kinase activity. J. Invest. Dermatol., 108:547, 1997.
101. Zi,
X., Steele, J.D., Mukhtar, H. and Agarwal, R.: Complete preventive effect of
silymarin against okadaic acid-caused tumor promotion in mouse skin. J. Invest.
Dermatol., 108:600, 1997.
102. Mukhtar,
H., Ahmad, N., Feyes, D.K. and Agarwal, R.: Cell cycle arrest and
induction of apoptosis in human epidermoid carcinoma cells A431 by green tea
polyphenols. J. Invest. Dermatol., 108:600, 1997.
103. Ahmad,
N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: Photodynamic therapy
results in WAF1/CIP1/P21-mediated cell cycle arrest in G1-phase followed by
apoptosis in human squamous carcinoma cells (A431). J. Invest. Dermatol.,
108:667, 1997.
104. Ahmad,
N., Feyes, D.K., Agarwal, R. and Mukhtar, H.: WAF1/CIP1/P21 mediates
G1 arrest in cell cycle and apoptosis by photodynamic therapy (PDT). Photochem.
Photobiol., 65s:58s, 1997.
105. Zi,
X. and Agarwal, R.: Anti-proliferative and apoptotic effects of a potent cancer
preventive agent silymarin are mediated via distinct signals involving respectively
ERK and JNK pathways. Proc. Am. Assoc. Cancer Res., 39:291, 1998.
106. Agarwal,
R. and Zi, X.: Silymarin decreases prostate specific antigen (PSA)
expression concomitant with inhibition of cell growth, induction of neuroendocrine
differentiation and perturbations in cell cycle in human prostate carcinoma cells
LNCaP. Proc. Am. Assoc. Cancer Res., 39:320, 1998.
107. Ahmad,
N., Agarwal, R. and Mukhtar, H.: Involvement of pRb/p105 and E2F during
photodynamic therapy mediated G0/G1-phase arrest of human epidermoid
carcinoma cells A431. Proc. Am. Assoc. Cancer Res., 39:378, 1998.
108. Agarwal,
R.: Skin cancer chemoprevention by a flavonoid antioxidant silymarin.
Experimental Skin Carcinogenesis: Third International Meeting, Bastrop, TX,
November, 1998.
109. Agarwal,
R.: Prostate Cancer Prevention by an antioxidant silymarin. International
Conference on Diet and Prevention of Cancer, Tampere, Finland, June, 1999.
110. Zhao,
J., Wang, Z.Y and Agarwal, R.: Biodistribution and sulfate- and
glucuronidate-conjugate formation of a skin cancer chemopreventive agent silymarin
in mice. Proc. Am. Assoc. Cancer Res., 40:258, 1999.
53
Rajesh Agarwal, Ph.D.
111. Bhatia,
N., Zi, X. and Agarwal, R.: Enhanced polyphenolic nature of flavonoid
antioxidants plays detrimental role in the activation of survival factor Akt and
apoptosis in prostate cancer DU145 cells: a comparison of silymarin, genistein and
EGCG. Proc. Am. Assoc. Cancer Res., 40:533, 1999.
112. Chen,
L, Zi, X. and Agarwal, R.: Differential impairment of signaling pathways by
skin cancer chemopreventive agents silymarin, quercetin and EGCG: a structure
activity response. Proc. Am. Assoc. Cancer Res., 40:533-534, 1999.
113. Zi,
X. and Agarwal, R.: Ligand-induced receptor tyrosine kinase endocytosis in
prostate cancer cells. Proc. Am. Assoc. Cancer Res., 40:614, 1999.
114. Jiang,
W., Zhu, Z., Bhatia, N., Agarwal, R. and Thompson, H.J.: Corticosterone
treatment of mouse mammary hyperplasia cells TM10 selectively induces G1 arrest
via induction of CDKIs and decrease in both CDKs and cyclin D1. Proc. Am. Assoc.
Cancer Res., 40:617, 1999.
115. Zi,
X. and Agarwal, R.: Impairment of erbB1-mediated endocytosis signaling by
phytic acid: a novel strategy for the secondary prevention of prostate cancer. Proc.
Am. Assoc. Cancer Res., 40:654, 1999.
116. Agarwal,
R.: Cell signaling, regulators of cell cycle and apoptosis as molecular
targets for prostate cancer intervention by dietary agents. Proc. Signal Transduction
Pathways and Regulation of Gene Expression as Therapeutic Targets, Luxembourg,
January, 2000.
117. Jiang,
C., Agarwal, R. and Lu, J.: Silymarin, a flavonoid phytochemical, inhibts key
angiogenic attributes of vascular endothelial cells. Proc. Am. Assoc. Cancer Res.,
41:847, 2000.
118. Agarwal,
C., Zhao, J. and Agarwal, R.: Grape seed polyphenols inhibit breast
carcinoma MDA-MB468 cell growth by inhibiting MAPKs, and inducing G1 arrest
and differentiation. Proc. Am. Assoc. Cancer Res., 41:532-533, 2000.
119. Bhatia,
N. and Agarwal, R.: Hydrogen peroxide-mediated pro-oxidant activity of
epigallocatechin-3 gallate in human prostate carcinoma DU145 cells: effect on cell
growth and viability, and MAP kinases. Proc. Am. Assoc. Cancer Res., 41:533,
2000.
120. Bhatia,
N., Sharma, Y., Zhao, J. and Agarwal, R.: Therapeutic efficacy of a cancer
preventive agent, silymarin: involvement of anti-proliferative and cell deletion effects
via inhibition of mitogenic signaling. Proc. Am. Assoc. Cancer Res., 41:663, 2000.
54
Rajesh Agarwal, Ph.D.
121. Sharma,
Y. and Agarwal, R.: A flavonoid antioxidant silibinin inhibits TGF
expression and its bining to erbB1 resulting in impairment of ligand/receptor
autocrine loop in human prostate carcinoma cells. Proc. Am. Assoc. Cancer Res.,
41:846, 2000.
122. Zhao,
J., Slaga, T.J. and Agarwal, R.: Inhibition of phorbol ester-caused oxidative
stress and inflammatory responses by a polyphenolic fraction from coffee. Proc. Am.
Assoc. Cancer Res., 41:846, 2000.
After Joining DOPS, SOP, UCHSC
123. Singh, R.P., Agarwal, C. and Agarwal, R.: Novel anti-carcinogenic function of
inositol hexaphosphate in human prostate carcinoma DU145 cells: modulation of
cell-cycle regulators, growth inhibition, and induction of G1 arrest. Proc. Am. Assoc.
Cancer Res., 42:461, 2001.
124. Tyagi,
A., Agarwal, C. and Agarwal, R.: Silibinin induces growth inhibition and G1
arrest via induction of CDKIs and decrease in CDKs leading to hypophosphorylation
of Rb/p107 in prostate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res.,
42:462, 2001.
125. Agarwal,
C., Singh, R.P., Tyagi, A.K. and Agarwal, R.: Anti-carcinogenic effect of
grape seed extract against prostate cancer. Proc. Am. Assoc. Cancer Res., 42:462,
2001.
126. Tyagi,
A., Agarwal, C., Chan, D.C. and Agarwal, R.: Strong synergistic efficacy of
silibinin and doxorubicin combination against human prostate carcinoma DU145
cells. Proc. Am. Assoc. Cancer Res., 42:462, 2001.
127. Agarwal,
R.: Silymarin and prostate cancer: epigenetic events as molecular targets.
1st Int. Conf. on Mechanisms of Action of Nutraceuticals, October, 2001.
128. Agarwal,
C., Dhanalakshmi, S. and Agarwal, R.: Anti-proliferative and apoptotic
effects of sililbinin in human colon cancer HT29 cells: Alterations in cell cycle
progression via CDKI induction concomitant with a decrease in kinase activity of
CDKs and associated cyclins. Proc. Am. Assoc. Cancer Res., 43:125, 2002.
129. Singh,
R.P., Dhanalakshmi, S., Tyagi, A.K., Chan, D.C.F., Agarwal, C. and Agarwal
R.: Dietary feeding of silibinin inhibits advanced human prostate carcinoma growth
in athymic nude mice, and increases plasma IGFBP-3 levels. Proc. Am. Assoc.
Cancer Res., 43:166, 2002.
130. Dhanalakshmi,
S., Agarwal, P., Glode, L.M. and Agarwal, R.: Silibinin sensitizes
DU145 prostate carcinoma cells to cisplatin- and carboplatin-induced growth
inhibition and apoptotic cell death. Proc. Am. Assoc. Cancer Res., 43:584, 2002.
55
Rajesh Agarwal, Ph.D.
131. Tyagi,
A.K., Agarwal, R. and Agarwal, C.: Procyanidin B3, isolated from grape seed
extract, induces strong growth inhibition and apoptotic death of human prostrate
carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 43:641, 2002.
132. Tyagi,
A., Agarwal, R. and Agarwal, C.: Grape seed extract inhibits the activation of
both constitutive and EGF-induced MAPK-Elk1-AP1 signaling pathway in human
prostrate carcinoma DU145 cells. Proc. Am. Assoc. Cancer Res., 43:642, 2002.
133. Agarwal,
C., Singh, R.P. and Agarwal, R.: Grape seed extract-induced apoptotic
death of prostate carcinoma DU145 cells: Involvement of caspases activation via
cytochrome C release. Proc. Am. Assoc. Cancer Res., 43:642, 2002.
134. Dhanalakshmi,
S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits
constitutive and TNF-induced activation of NF-B and sensitizes human prostate
carcinoma DU145 cells to TNF-induced apoptosis. Proc. Am. Assoc. Cancer Res.,
43:642, 2002.
135. Lu,
J., Wang, Z., Tyagi, A. and Agarwal, R.: Lack of preventive effect of dietary
silymarin on 1-methyl-1-nitrosourea-induced rat mammary carcinogenesis: Is organ
site specificity implied? Proc. Am. Assoc. Cancer Res., 43:823, 2002.
136. Agarwal,
R.: Modulation of cell cycle regulators in prostate cancer prevention by
silibinin. The Cell Cycle as a Target in Chemoprevention and Cancer Therapy
Conference, 3rd International Conference, Austin, TX, October 2002.
137. Qi,
L., Singh, R, Harrison, G.S., Agarwal, R. and Glode, L.M.: The EGF receptor is
necessary and sufficient to mediate silibinin mediated cytotoxicity in transfected 9L
glioma cells. ASCO Molecular Therapeutics Symposium, San Diego, CA, November
8-10, 2002.
138. Kim,
N.-C., Graf, T. N., Oberlies, N. H., Wani, M. C., Wall, M. E., Agarwal, C.,
Agarwal, R. and Kroll, D. J.: Selective activity of pure flavonolignans from milk
thistle (Silibum marianum) against human prostate carcinoma cell lines. Proc. Am.
Assoc. Cancer Res., 44:105, 2003.
139. Singh,
R.P., Sharma, G., Mallikarjuna, G. U., Dhanalakshmi, S., Agarwal, C. and
Agarwal, R.: Inositol hexaphosphate inhibits advanced human prostate tumor
growth and angiogenesis in athymic nude mice. Proc. Am. Assoc. Cancer Res.,
44:200, 2003.
140. Agarwal,
C., Dhanalakshmi, S., Singh, R. P. and Agarwal, R.: Antiangiogenic effect
of grape seed extract in human prostate cancer xenograft in athymic nude mice.
Proc. Am. Assoc. Cancer Res., 44:221, 2003.
56
Rajesh Agarwal, Ph.D.
141. Tyagi,
A. K., Singh, R. P., Agarwal, C., Shroyer, K., Glode, L. M. and Agarwal, R.:
Silibinin down-regulates survivin mRNA and protein expression accompanied by G2M arrest and apoptosis in human bladder transitional-cell papilloma RT4 cells. Proc.
Am. Assoc. Cancer Res., 44:223, 2003.
R.: Silibinin and prostate cancer-targeting EGFR. Proc. 21st Annual
Meeting, Mountain West Society of Toxicology – Toxicology and Natural Products.
September 2003, Breckenridge, CO.
142. Agarwal,
143. Roy,
S., Agarwal, C., Dhanalakshmi, S. and Agarwal, R.: Antiproliferative effect of
inositol hexaphosphate on rat prostate cancer cells. Proc. 21 st Annual Meeting,
Mountain West Society of Toxicology – Toxicology and Natural Products.
September 2003, Breckenridge, CO.
R.: Molecular mechanism of silibinin efficacy in prostate cancer. 8 th World
Congress on Advances in Oncology, October 2003, Crete, Greece.
144. Agarwal,
145. Majeed,
N., Blouin, M.-J., Agarwal, R., Greenberg, N. and Pollak, M.: Oral feeding
of silibinin reduces in vivo prostate cancer incidence and circulating IGF-1 in the
TRAMP transgenic model. Proc. Second Annual AACR International Conference on
Cancer Prevention Research: Frontiers in Cancer Prevention Research, A183,
October 2003, Phoenix, AZ, Cancer Epidemiol. Biomarkers Prev., 12 :1297S-1298S,
2003.
146. Singh,
R.P. and Agarwal, R.: Silibinin inhibits growth and causes apoptotic death of
endothelial cells via modulation of survivin and mitochondrial apoptosis. AACR
Special Conference on Angiogenesis, October 2003, Chicago, IL.
147. Kaur,
M., Agarwal, C., Singh, R.P., Dwivedi, C., Guan, X. and Agarwal, R.: Alphasantalol induces apoptotic cell death in human epidermoid carcinoma A431 cells.
Proc. Am. Assoc. Cancer Res., 45:167, 2004.
148. Singh,
R.P., Agrawal, P., Yim, D. and Agarwal, R.: Growth inhibitory and apoptotic
effects of linarin, linarin acetate and acacetin on human prostate carcinoma cells.
Proc. Am. Assoc. Cancer Res., 45:171, 2004.
149. Dhanalakshmi,
S., Mohan, S., Singh, R.P., Mallikarjuna, G.U. and Agarwal, R.:
Silibinin enhances UVB-induced apoptosis in human epidermoid carcinoma A431
cells via proapoptotic mitochondrial proteins and caspases activation. Proc. Am.
Assoc. Cancer Res., 45:315, 2004.
150. Dhanalakshmi,
S., Agarwal, C. and Agarwal, R.: Silibinin enhances UVB-induced
MAPK/Erk1/2 activation, p53-ser 15 phosphorylation and accumulation in mouse
epidermal JB6 cells: Possible role in protection against photocarcinogenesis. Proc.
Am. Assoc. Cancer Res., 45:318-319, 2004.
57
Rajesh Agarwal, Ph.D.
151. Singh,
R.P., Mallikarjuna, G.U., Sharma, G., Dhanalakshmi, S., Tyagi, A., Chan, D.,
Agarwal, C. and Agarwal, R.: Silibinin reduces toxicity and enhances therapeutic
efficacy of doxorubicin in lung cancer. Proc. Am. Assoc. Cancer Res., 45:460, 2004.
152. Mallikarjuna,
G.U., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.:
Protective effects of silibinin against photocarcinogenesis in SKH-1 hairless mice.
Proc. Am. Assoc. Cancer Res., 45:513, 2004.
153. Yim,
D.S., Singh, R.P., Lee, S.Y., Agarwal, C. and Agarwal, R.: A novel anticancer
agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma
DU145 cells. Proc. Am. Assoc. Cancer Res., 45:689, 2004.
154. Tyagi,
A., Agarwal, C., Glode, L.M. and Agarwal, R.: Silibinin efficacy in human
bladder transitional cell carcinoma: modulation of cell cycle and apoptosis cascades.
Proc. Am. Assoc. Cancer Res., 45:730, 2004.
155. Agarwal,
C. and Agarwal, R.: Inositol hexaphosphate inhibits growth, and induces
G1 arrest and apoptotic death of prostate carcinoma LNCaP cells. Proc. Am. Assoc.
Cancer Res., 45:902-903, 2004.
156. Dhanalakshmi,
S., Mallikarjuna, G.U., Singh, R.P. and Agarwal, R.: Silibinin inhibits
ultraviolet B-caused skin damage via up-regulation of p53 and p21/cip1 in SKH-1
hairless mice. Proc. Am. Assoc. Cancer Res., 45:932-933, 2004 (Mini-symposia).
157. Singh,
R.P., Sharma, G., Dhanalakshmi, S., Glode, L.M. and Agarwal, R.: Silibinin
inhibits human bladder transitional-cell papilloma RT4 tumor xenograft growth in
athymic nude mice. Proc. Am. Assoc. Cancer Res., 45:1269-1270, 2004.
158. Agarwal,
R.: Prostate Cancer Chemoprevention by Silibinin. Proceedings - Dietary
Factors and Cancer Prevention: Current Premises and Future Promises, Rochester,
MN, September 23-25, 2004.
R.: Prostate Cancer Prevention by IP6: Targeting Cell Cycle Regulation”
Proceedings - IP6 and Cell Signaling in Fighting Cancer: From Laboratory to Clinic
Symposium held at the 7th International Conference of Anticancer Research, Corfu,
Greece, October 25-30, 2004.
159. Agarwal,
160. Agarwal,
R., Su, L.-J., Flaig, T., Harrison, G.S., Gustafson, D. and Glode, L.M.: A
phase I clinical study of silibinin in patients with prosate cancer. Prostate Cancer
Foundation (CapCure), October 2004.
161. Agarwal,
C., Dhanalakshmi, S. and Agarwal, R.: Silibinin inhibits TNF-induced NFB activation via IKK-IB pathway in human colon carcinoma cells: possible
implications in colorectal cancer prevention and intervention. Proceedings 24th
Annual Convention of IACR, New Delhi, India, February 9-12, 2005.
58
Rajesh Agarwal, Ph.D.
162. Agarwal,
R.: IP6 prevents prostate cancer by modulating cell cycle regulators.
Proceedings 24th Annual Convention of IACR, New Delhi, India, February 9-12,
2005.
163. Kaur,
M., Agarwal, R. and Agarwal, C.: Grape Seed Extract induces apoptosis in
human prostate carcinoma LNCaP cells: possible roles of anoikis, and mitogenactivated protein kinases and caspases activation. Proc. Am. Assoc. Cancer Res.,
46:365, 2005.
164. Agarwal,
R., Mallikarjuna, Gu., Dhanalakshmi, S., Mohan, S. and Singh, R.P.:
Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and
associated proliferation and apoptosis in SKH-1 mouse skin: implications for the
prevention of photocarcinogenesis. Proc. Am. Assoc. Cancer Res., 46:575, 2005.
165. Roy,
S., Kaur, M., Agarwal, C., Singh, R.P. and Agarwal, R.: Role of cyclindependent kinase inhibitors p21 and p27 in silibinin-induced G1 arrest in DU145
prostate cancer cells. Proc. Am. Assoc. Cancer Res., 46:575, 2005.
166. Tyagi,
A., Agarwal, C. and Agarwal, R.: Silibinin induces apoptosis in human
bladder transitional cell papilloma RT4 cells by activating p53 and Chk2 in an ATMdependent manner and cleavage of Bid. Proc. Am. Assoc. Cancer Res., 46:575576, 2005.
167. Deep,
G., Singh, R.P., Agarwal, C., Kroll, D.J. and Agarwal, R.: Distinct efficacy of
silibinin in causing G1 and G2-M arrests via cyclins-CDK-CDK inhibitors and Chk2Cdc25C-Cdc2-cyclin B1 circuitries in human prostate cancer PC3 cells - comparison
with crude form silymarin. Proc. Am. Assoc. Cancer Res., 46:576, 2005.
168. Mohan,
S., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin
inhibits UVB- and EGF-induced mitogenic MAPK-AP1 and cell survival Akt-NF-kB
signaling in mouse epidermal JB6 cells: Possible role in protection against skin
tumor promotion. Proc. Am. Assoc. Cancer Res., 46:576, 2005.
169. Singh,
R.P., Varghese, L., Dhanalakshmi, S. and Agarwal, R.: In vitro as well as in
vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and
Panc-1 cells. Proc. Am. Assoc. Cancer Res., 46:579-580, 2005.
59
Rajesh Agarwal, Ph.D.
170. Mallikarjuna,
G.U., Dhanalakshmi, S., Mohan, S., Singh, R.P. and Agarwal, R.:
Protective efficacy and associated mechanisms of silibinin against UVB-induced
skin tumorigenesis in SKH-1 hairless mice. Proc. Am. Assoc. Cancer Res., 46:1016,
2005.
171. Agarwal,
C., Veluri, R., Thompson, J.A. and Agarwal, R.: Biofractionation of GSE:
Identification of gallic acid as one of the major active constituents causing growth
inhibition, S phase arrest and apoptotic death of DU145 human prostate carcinoma
cells. Proc. Am. Assoc. Cancer Res., 46:1227, 2005.
172. Varghese,
L., Agarwal, C., Tyagi, A. and Agarwal, R.: Silibinin induces cell cycle
arrest in human hepatocellular carcinoma HepG2 and Hep3B cells by modulating
cyclin-cyclin dependant kinase-cyclin dependant kinase inhibitor levels and activity.
Proc. Am. Assoc. Cancer Res., 46:1231-1232, 2005.
173. Chitterzhath,
M., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin inhibits
cytokines-induced STATs, MAPKs and NF-B activation and down regulates HIF-1
and iNOS in human lung epithelial A549 cells: Possible role in angioprevention of
lung tumorigenesis. Proc. Am. Assoc. Cancer Res., 46:1232, 2005.
174. Flaig,
T., Agarwal, R., Su, L.J., Harrison, G.S., Gustafson, D. and Glode, L.M.: A
phase I study of silibinin in hormone refractory prostate cancer. J. Clin. Oncol.
23:427s, 2005.
175. Veluri,
R., Agarwal, R., Thompson, J.A. and Agarwal, C.: LC/MS identification of
gallic acid and procyanidins from grape seeds with anti-cancer activity in DU145
human prostate carcinoma cells. Proc. Annual Meeting of the Amer. Chem. Soc.,
2005.
R.: Prostate cancer prevention by silibinin – bench to bedside.
Proceedings: Targeting Carcinogenesis, Rochester, MN, October 6 th to 7th, 2005.
176. Agarwal,
177. Agarwal,
R.: Modulation of cell cycle regulators in prostate cancer prevention by
silibinin. Proceedings, 3rd Joint Meeting of the Society for Free Radical Research
Australia and Japan, Gold Coast, December 2-5, 2005, page 44.
178. Agarwal,
C., Dhanalakshmi, S. and Agarwal, R.: Silibinin inhibits NF-kB activation
via IKKalpha-IkBalpha in human colorectal carcinoma cells. Proceedings, 3rd Joint
Meeting of the Society for Free Radical Research Australia and Japan, Gold Coast,
December 2-5, 2005, page 128.
179. Flaig,
T., Su, L.J., Harrison, G., Agarwal, R. and Glodé, L.M.: Silibinin synergizes
with mitoxantrone to decrease cell viability in prostate cancer cells. ASCO, 2006.
60
Rajesh Agarwal, Ph.D.
180. Kaur,
M., Agarwal, R. and Agarwal, C.: Grape seed extract induces cell cycle arrest
Waf1
via up-regulation of p21
and down-regulation of cyclins-cyclin dependent
kinases, and causes apoptotic death of human colorectal carcinoma LoVo, HT29
and SW480 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5,
2006.
181. Raina,
K., Katiyar, S., Agarwal, C. and Agarwal, R.: Silibinin inhibits ligand-induced
EGFR and Akt phosphorylation, and causes cell cycle arrest and apoptosis in
human colorectal carcinoma SW480 cells. Proc. 97th AACR Annual Meeting,
Washington, DC, April 1-5, 2006.
182. Singh,
R. P., Sharma, G. and Agarwal, R.: Silibinin consumption inhibits prostate
tumor growth in transgenic adenocarcinoma of mouse prostate (TRAMP) mice.
Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.
183. Gu,
M., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Silibinin
inhibits UVB-induced skin tumorigenesis by down-regulating STAT3 and NF-κB
activation. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.
184. Roy,
S. and Agarwal, R.: Protective effect of silibinin against ultraviolet B radiationinduced apoptosis in mouse epidermal JB6 cells involves prolonged p53 serine15
phosphorylation. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5,
2006.
185. Deep,
G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B causes androgen
receptor degradation via PI3K-Akt-Mdm2 pathway leading to a decrease in prostate
specific antigen and cell cycle arrest in LNCaP human prostate carcinoma cells.
Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.
186. Gu,
M., Dhanalakshmi, S., Singh, R.P., Agarwal, C. and Agarwal, R.: Inositol
hexaphosphate down-regulates both constitutive and ligand-induced mitogenic and
cell survival signaling, and causes caspase-mediated apoptotic death of human
prostate carcinoma PC3 cells. Proc. 97th AACR Annual Meeting, Washington, DC,
April 1-5, 2006.
187. Tyagi,
A., Tyagi, A., Chan, D., Agarwal, C. and Agarwal, R.: Grape seed extract
sensitizes human breast carcinoma cells to chemotherapy agents-induced growth
inhibition and apoptotic death via cytochrome c release and caspase activation
pathway. Proc. 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006.
188. Agarwal,
C., Tyagi, A. and Agarwal, R.: Gallic acid, the major active constituent in
grape seed extract, causes S phase arrest via activation of ATM-Chk1/2-Cdc25A/CCdc2 pathway, and leads to caspase-mediated apoptotic death of human prostate
carcinoma DU145 cells. Proc. 97th AACR Annual Meeting, Washington, DC, April 15, 2006.
61
Rajesh Agarwal, Ph.D.
189. Agarwal,
R.: Skin Cancer Prevention by Silibinin. International Conference:
Frontiers of Pharmacology and Toxicology, Chicago, IL, August 29 th, 2006.
Chemico-Biological Intercations, 161: S26, 192-193, 2006.
190. Graf,
T.N., Kroll, D.J., Agarwal R., Wani, M.C. and Oberlies, N.H.: Preparation of
large-scale samples of the major bioactive constituents in milk thistle (Silybum
marianum (L.) Gaertn.) for preclinical investigations of prostate cancer
chemoprevention and treatment. 2006 AACR International Conference on Frontiers
in Cancer Prevention Research, Boston, MA.
191. Pappa,
A., Milikowsky, J.M., Agarwal, R., Wani, M.C., Oberlies, N.H. and Kroll,
D.J.: Flavonolignans from extracts of milk thistle (Silybum marianum) suppress
biomarkers of prostate oncogenesis and colon carcinoma cell proliferation
independently of p53 or p21. 2006 AACR International Conference on Frontiers in
Cancer Prevention Research, Boston, MA.
192. Agarwal,
R.: Molecular mechanism of prostate cancer prevention by a dietary
nutrient inositol hexaphosphate. Proc. of The 3rd APOCP Conference “Empowering
Cancer Prevention in the Asian Pacific”, Bangkok, Thailand, November 3-5, 2006.
193. Agarwal,
R.: Prostate cancer prevention by silibinin: how close we are to bedside?
International Radiation Oncology Conference Special Session on Cancer
Chemoprevention, Varanasi, India, Abstract #180, November 20-22, 2006.
194. Agarwal,
C. and Agarwal, R.: Grape seed extract inhibits human colorectal
carcinoma growth by inducing Cip1/p21, cell cycle arrest and apoptosis.
International Radiation Oncology Conference Special Session on Cancer
Chemoprevention, Varanasi, India, Abstract #179, November 20-22, 2006.
R.: Prostate cancer prevention by flavonoid silibinin. 4th Bio/Molecular
Informatics Center International Symposium entitled “Flavonoids: old subjects but
new challenges” held at Konkuk University, Seoul, Korea; February 7, 2007.
195. Agarwal,
196. Agarwal,
R.: Molecular mechanism of prostate cancer prevention by a dietary
nutrient inositol hexaphosphate” at Natural Products, Diets and Cancer Prevention
Session of the American Chemical Society Natioanl Meeting, Chicago, IL. March
25th, 2007.
197. Tewari-Singh, N.,
R.: Biological and
Rana, S., Gu, M., Agarwal, C., Day, B.J., White, C.W . and Agarwal,
Molecular markers for CEES-induced skin injury in JB6 cells. 1st
Annual CounterACT Network Research Symposium, April 25-27, 2007, Arlington
VA.
198. Rana,
S., Tewari-Singh, N., Gu, M., White, C.W. and Agarwal, R.: In Vivo studies
to develop CEES-induced skin toxicity models. 1st Annual CounterACT Network
Research Symposium, April 25-27, 2007, Arlington VA.
62
Rajesh Agarwal, Ph.D.
199. Agarwal,
C., Veluri, R., Kaur, M., Chou, S.-C., Thompson, J.A. and Agarwal, R.:
Fractionation of high molecular weight tannins in grape seed extract and
identification of procyanidin B2-3,3’-di-O-gallate as a major active constituent
causing growth inhibition and apoptotic death of DU145 human prostate carcinoma
cells. Mini-symposium Preclinical Prevention Studies 1: Novel Agents. 2007 AACR
Annual Meeting, Los Angeles, CA, April 14-18, 2007.
200. Raina,
K., Singh, R. P., Agarwal, R. and Agarwal, C.: Chemoprevention of prostate
cancer by grape seed extract in a transgenic mouse model. 2007 AACR Annual
Meeting, Los Angeles, CA, April 14-18, 2007.
201. Agarwal,
R., Agarwal, C. and Tyagi, A.: Silibinin inhibits constitutive activation of
Stat3, and causes caspase activation and apoptotic death of human prostate
carcinoma DU145 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18,
2007.
202. Tyagi,
A., Singh, R.P., Agarwal, C., Harrison, G., Glode, M.L. and Agarwal, R.:
Chemopreventive effect of silibinin and silymarin on n-butyl-n-(4hydroxybutyl)
nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. 2007 AACR
Annual Meeting, Los Angeles, CA, April 14-18, 2007.
203. Singh,
R.P., Deep, G. and Agarwal, R.: Dietary feeding of silibinin inhibits PC-3
tumor xenograft growth via ERK1/2 activation and an increase in Cip1/p21 and
Kip1/p27 expression. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18,
2007.
204. Deep,
G., Oberlies, N.H., Kroll, D.J. and Agarwal, R.: Isosilybin B and isosilybin A
inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer
LNCaP and 22Rv1 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 14-18,
2007.
205. Gu,
M., Singh, R. P. and Agarwal, R.: Silibinin inhibits in vivo growth of colorectal
cancer by inhibiting tumor cell proliferation and angiogenesis in athymic nude mice.
2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.
206. Kaur,
M., Agarwal, R. and Agarwal, C.: Gallic acid, a major active constituent of
grape seed extract, induces apoptotic death via the activation of p38 MAPK pathway
in human prostate carcinoma DU145 cells. 2007 AACR Annual Meeting, Los
Angeles, CA, April 14-18, 2007.
207. Dwyer-Nield,
L.D., Singh, R.P., Tyagi, A., Malkinson, A.M. and Agarwal, R.:
Therapeutic efficacy of silibinin on chemically-induced mouse lung tumors. 2007
AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.
63
Rajesh Agarwal, Ph.D.
208. Roy,
S. and Agarwal, R.: Silibinin inhibits apoptosis, reduces DNA lesions and
modulates cell cycle events in a p53-dependent manner in ultraviolet B-irradiated
mouse epidermal JB6 cells. 2007 AACR Annual Meeting, Los Angeles, CA, April 1418, 2007.
209. Balaiya,
V., Singh, R.P., Tyagi, A. and Agarwal, R.: Inhibition of azoxymethaneinduced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.
2007 AACR Annual Meeting, Los Angeles, CA, April 14-18, 2007.
210. Mateen,
S., Tyagi, A. and Agarwal, R.: Anti Cancer Efficacy of Silibinin and
Erlotinib in human Non-small-cell lung cancer cells. 25th Annual Meeting of the
Mountain West Society of Toxicology, Breckenridge, CO, September, 2007.
211. Roy,
S. and Agarwal, R.: Silibinin protects against UVB-induced damage by
regulating cell cycle events, DNA repair and apoptosis in a P53- and GADD45dependent manner. 25th Annual Meeting of the Mountain West Society of
Toxicology, Breckenridge, CO, September, 2007.
212. Agarwal,
R.: Recent advances in mechanism of cancer chemoprevention by grape
seed extract. 12th World Congress on Advances in Oncology and 10 th International
Symposium on Molecular Medicine: Bioactive Food Components, Alternative
Medicine and Cancer Chemoprevention: Recent Advances. Crete, Greece, October,
2007.
R.: Lung cancer chemoprevention by silibinin. 9 th International
Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis. Jeju
Island, S. Korea, December 1-5, 2007.
213. Agarwal,
214. Agarwal,
R.: Chemoprevention of Prostate Cancer by Silibinin: Bench to Bedside.
18th All India Congress of Zoology and SCIAZE, University of Lucknow, Lucknow,
India, December 7-9, 2007.
R.: Silibinin and Angioprevention – an upcoming strategy. 2nd International
Symposium on Translational Research on Natural Products and Cancer. Lonavala,
Mumbai, India, December 9-12, 2007.
215. Agarwal,
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