SHORT CURRICULUM VITAE
NAME:
Charles Dickson PUSEY
ADDRESS:
Renal Section, Department of Medicine, Imperial College London,
Hammersmith Campus, Du Cane Road, London W12 0NN
DATE OF BIRTH:
7 June 1948
PLACE OF BIRTH:
Hamilton, Scotland
QUALIFICATIONS:
1969
1972
1973
1973
1974
BA (Cantab)
BChir (Cantab)
MB (Cantab)
MA (Cantab)
MRCP (UK)
1983
1989
1997
2002
2002
2009
MSc (Lond)
FRCP (Lond)
FRCPath (Lond)
DSc (Lond)
FMedSci
FASN
PRESENT APPOINTMENTS:
Oct 84 - date
Hon Consultant Physician, Directorate of Renal Medicine & Transplantation,
Imperial College Healthcare NHS Trust
Apr 01 – date
Lead Clinician, Directorate of Renal Medicine & Transplantation, Imperial College
Healthcare NHS Trust
Apr 07 – date
Theme Leader, Renal Medicine and Transplantation, NIHR Comprehensive
Biomedical Research Centre, Imperial College Healthcare NHS Trust
Mar 08 – date
Director of Education, Imperial College Healthcare NHS Trust
Aug 03 - date
Professor of Medicine and Head of Renal Section, Department of Medicine,
Imperial College London
Mar 06 - date
Head of Postgraduate Medicine, Imperial College London
Mar 06 – date
Director, NIHR Integrated Academic Training Path, Imperial College London
Nov 07 – date
Director, Wellcome Trust Clinical PhD Programme, Imperial College London
PREVIOUS APPOINTMENTS:
Apr 07 – Apr 09
Director, NIHR Comprehensive Biomedical Research Centre,
Imperial College Healthcare NHS Trust
Jun 05 – May 08
Director of Research and Development, Hammersmith Hospitals NHS Trust
Dec 02 – Jun 07
Chairman, Kidney Research UK (previously The National Kidney Research Fund)
Jan 01 – Jul 05
Academic Registrar, Royal College of Physicians of London
Aug 97 – Jul 03
Professor of Renal Medicine and Head of Renal Section, Division of Medicine,
Imperial College London
Hon Consultant Physician and Lead Clinician, Division of Renal Medicine and
Transplantation, Hammersmith Hospitals NHS Trust
Dec 94 - Jul 97
Professor of Renal Medicine and Head of Renal Unit, Royal Postgraduate
Medical School
Hon Consultant Physician, Division of Renal Medicine and Transplantation,
Hammersmith Hospital
PERSONAL RESUME:
Charles Pusey is currently Professor of Medicine, Head of the Renal Section in the Department of
Medicine, and Head of Postgraduate Medicine in the Faculty of Medicine at Imperial College London.
He is also Honorary Consultant Physician and Lead Clinician in the West London Renal and Transplant
Centre, and Director of Education at Imperial College Healthcare NHS Trust. He qualified from
Cambridge University and Guy’s Hospital London and, after early appointments at Guy’s, joined the
Royal Air Force, where he gained experience in General Practice, General Medicine and Renal
Medicine. On leaving the RAF, he moved to Hammersmith Hospital as Senior Registrar in Renal and
General Medicine to Professor Keith Peters. He started his clinical research on a MRC Training
Fellowship and was subsequently awarded a Wellcome Trust Senior Fellowship in Clinical Science.
This led to his appointment as Senior Lecturer, Reader and then Professor of Renal Medicine at the
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Royal Postgraduate Medical School, later merged with Imperial College London. He remains active in
clinical practice in all aspects of renal medicine, and leads a large multidisciplinary vasculitis service.
He has continued both clinical and laboratory-based research in parallel, and his work has focused on
the causes and treatment of glomerulonephritis and systemic vasculitis. He has published over 350
articles on renal disease, contributed chapters to the standard textbooks on renal and general
medicine, and edited several books on renal disorders. He has a wide range of teaching commitments
at undergraduate and postgraduate levels, and regularly supervises several PhD students. He has a
particular interest in clinical academic training, and served as Academic Registrar at the Royal College
of Physicians of London. He has previously been President of the Nephrology Section of the Royal
Society of Medicine, Chairman of Kidney Research UK, and Director of Research and Development at
Hammersmith Hospitals NHS Trust. He was elected Fellow of the Academy of Medical Sciences in
2002, Senior Investigator of the National Institute of Health Research in 2008, and Fellow of the
American Society of Nephrology in 2009.
RECENT PUBLICATIONS:
1.
Khan SB, Cook HT, Bhangal G, Smith J, Tam FWK, Pusey CD. Antibody blockade of TNF reduces
inflammation and scarring in experimental crescentic glomerulonephritis. Kidney Int 2005; 67: 18121820.
2.
Reynolds J, Prodromidi, E, Juggapah J, Holthaus K, Kalluri R, Pusey CD. Nasal administration of
recombinant rat 3(IV)NC1) prevents the development of experimental autoimmune glomerulonephritis
in the WKY rat. J Am Soc Nephrol 2005; 16: 1350-1359.
3.
Lai P, Smith J, Bhangal G, Chaudhry KA, Chaudhry AN, Keith JC Jr, Tam FWK, Pusey CD, Cook HT.
Interleukin 11 reduces renal injury and glomerular NF-κB activity in murine experimental
glomerulonephritis. Nephron Exp Nephrol 2005; 101: e146-e154.
4.
Little MA, Smyth CL, Yadav R, Ambrose L, Cook T, Nourshargh S, Pusey CD. Anti-neutrophil
cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions
in vivo. Blood 2005; 106: 2050-2058.
5.
Ambrose LR, Little MA, Nourshargh S, Pusey CD. Anti-proteinase 3 antibody binding to neutrophils as
demonstrated by confocal microscopy. Kidney int 2005; 68: 2912-2913.
6.
Little MA, Bhangal G, Smyth CL, Nakada MT, Cook HT, Nourshargh S, Pusey CD. Therapeutic effect
of anti-TNF antibodies in an experimental model of ANCA-associated vasculitis. J Am Soc Nephrol
2006; 17: 160-169.
7.
Aitman TJ, Dong R, Vyse TJ, Norsworthy P, Johnson MD, Smith J, Mangion J, Roberton-Lowe C,
Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR,
Evans DJ, Domin J, Flint J, Boyle J, Pusey CD, Cook HT. Copy number polymorphism in Fcgr3
predisposes to glomerulonephritis in rats and humans. Nature 2006; 439: 851-855.
8.
George A, Tokars J, Clutterbuck EJ, Bamford K, Pusey C, Holmes AH. Reducing dialysis associated
bacteraemia, and recommendations for UK surveillance. Br Med J 2006; 332:1435.
9.
Coker R, Kiani-Alikhan S, Stewart A, Pusey C, Dale RG, Jones B. Plasma TGF1 during pelvic
radiotherapy for gynaecological malignancy. Acta Oncologica 2006; 45: 753-754.
10. Arduini A, Bonomini M, Clutterbuck EJ, Laffan MA, Pusey CD. Effect of L-carnitine administration on
erythrocyte survival in haemodialysis patients. Nephrol Dial Transplant 2006; 21: 2671.
11. Coker R, Kiani-Alikhan S, Stewart A, Pusey C, Dale RG, Jones B. Plasma TGFbeta1 during pelvic
radiotherapy for gynaecological malignancy. Acta Oncol 2006; 45: 753-754.
12. Prodromidi E, Poulsom R, Jeffery R, Roufosse CA, Pollard PJ, Pusey CD, Cook HT. Bone marrow
derived-cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model
of Alport syndrome. Stem Cells 2006; 21: 3349-3353.
13. Reynolds J, Albouainain A, Duda M, Evans DJ, Pusey CD. Strain susceptibility to active induction and
passive transfer of experimental autoimmune glomerulonephritis in the rat.
Nephrol Dial
Transplantation 2006; 21: 3398-3408.
14. Chen L, Hellmark T, Pedchenko V, Hudson BG, Pusey CD, Fox JW, Bolton WK. A nephritogenic
peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune
glomerulonephritis. J Am Soc Nephrol 2006; 17: 3076-3081.
15. Mosley M, Tam FWK, Edwards RJ, Crozier J, Pusey CD, Lightstone L. Urinary proteomic profiles
distinguish between active and inactive lupus nephritis. Rheumatol 2006; 45: 1497-1504.
16. Turner CM, Tam FW, Lai PC, Tarzi RM, Burnstock G, Pusey CD, Cook HT, Unwin RJ. Increased
expression of the pro-apoptotic ATP-sensitive P2X7 receptor in experimental and human
glomerulonephritis. Nephrol Dial Transplant 2006; 22: 386-395.
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17. Feldmann M, Pusey CD. Is there a role for TNF-neutrophil cytoplasmic antibody-associated
vasculitis? Lessons from other chronic inflammatory diseases. J Am Soc Nephrol 2006 17: 12431252.
18. Smith J, Lai PC, Behmoras J, Roufosse C, Bhangal G, McDaid JP, Aitman Tam FW, Pusey CD, Cook
HT. Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic
susceptibility to crescentic glomerulonephritis in the rat. J Am Soc Nephrol 2007; 18: 1816-1823.
19. Sheryanna A, Bhangal G, McDaid J, Smith J, Manning A, Foxwell BM, Feldmann M, Cook HT, Pusey
CD, Tam FW. Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of
experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but
not IL-1beta or IL-16. J Am Soc Nephrol 2007; 18: 1167-1179.
20. Fanciulli M, Norsworthy PJ, Petretto E, Dong R, Harper L, Kamesh L, Heward JM, Gough SC, de
Smith A, Blakemore AI, Froguel P, Owen CJ, Pearce SH, Teixeira L, Guillevin L, Graham DS, Pusey
CD, Cook HT, Vyse TJ, Aitman TJ. FCGR3B copy number variation is associated with susceptibility to
systemic, but not organ-specific, autoimmunity. Nat Genet 2007 39: 721-723.
21. Jayne DR, Gaskin G, Rasmussen N, Abramowicz D, Ferrario F, Guillevin L, Mirapeix E, Savage CO,
Sinico RA, Stegeman CA, Westman KW, van der Woude FJ, de Lind van Wijngaarden RA, Pusey
CD. Randomised trial of plasma exchange or high dose methylprednisolone as adjunctive therapy for
severe renal vasculitis. J Am Soc Nephrol 2007; 18:2180-2188.
22. Laing CM, Roberts R, Lightstone L, Graham A, Cook TH, Summers S, Pusey CD. A patient with
suspected miscarriage is found to have hypertension, renal: failure and thrombocytopenia: case
outcome. Br Med J 2007; 28: 205-206.
23. Harper L, Kashiwagi Y, Pusey CD, Hendry BM, Domin J. PDGF re-organizes the actin cytoskeleton
through phosphoinositide 3-kinase dependent and independent mechanisms in human mesangial
cells. Nephron Physiol 2007; 107: 45-56.
24. Satchell SC, Buchatska O, Khan SB, Bhangal G, Tasman CH, Saleem MA, Baker DP, Lobb RR,
Smith J, Cook HT, Mathieson PW, Pusey CD. Interferon-beta reduces proteinuria in experimental
glomerulonephritis. J am Soc Nephrol 2007; 18: 2875-2884.
25. Nouraei SAR, Obholzer R, Ind PW, Salama AD; Pusey CD, Porter F, Howard DJ, Sandhu GS.
Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to
tracheobronchial Wegener’s Granulomatosis. Thorax 2008; 63: 49-52.
26. de Lind van Wijngaarden RAF, Hauer HA, Wolterbeek R, Jayne DRW, Gaskin G, Rasmussen N, Noel
L-H, Ferrario F, Waldherr R, Bruijn JA, Bajema IM, Hagen EC, Pusey CD. Chances of renal recovery
for dialysis-dependent ANCA-associated glomerulonephritis. J Am Soc Nephrol 2007; 18: 2189-2197.
27. Salama AD, Cook HT, Pusey CD, Pepper RJ. A case of treated ANCA-associated vasculitis with
recurrent renal failure. Clin J Am Soc Nephrol 2008; 3: 637-645.
28. Guillot PV, Cook HT, Pusey CD, Fisk NM, Harten S, Moss J, Shore I, Bou-Gharios G. Transplantation
of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type 12-deficient
mouse. J Pathol 2008; 214: 627-636.
29. Pepper RJ, Fabre MA, Pavesio C, Gaskin G, Jones RB, Jayne D, Pusey CD, Salama AD. Rituximab
is effective in the treatment of refractory Churg-Strauss syndrome and is associated with diminished
T-cell interleukin-5 production. Rheumatol 2008; 47: 1104-1105.
30. Behmoaras J, Bhangal G, Smith J, McDonald K, Mutch B, Lai PC, Domin J, Game L, Salama A,
Foxwell BM, Pusey CD, Cook HT, Aitman TJ. Jund is a determinant of macrophage activation and is
associated with glomerulonephritis susceptibility. Nature Genet 2008; 40: 553-559.
31. Segal T, Webb E, Viner R, Pusey C, Wild G, Algrove J. Severe insulin resistance secondary to
insulin antibodies: successful treatment with the immunosuppressant MMF. Pediatr Diabetes 2008; 9:
250-254.
32. Saw VPJ, Cornelius N, Salama AD, Pusey C, Lightman S. Infliximab therapy for aggressive Mooren
ulceration. Arch Ophthalmol 2008; 126: 734.
33. Reynolds J, Haxby J, Juggapah JK, Evans DJ, Pusey CD. Identification of a nephritogenic
immunodominant B and T cell epitope in experimental autoimmune glomerulonephritis. Clin Exp
Immunol 2008; 155:311-319.
34. Lutz J, Luong L, Strobl M, Deng M, Huang H, Anton M, Enesa K, Zakkar M, Chaudhury H, Haskard D,
Harten S, Maxwell P, Pusey C, Heemann U, Evans P. The A20 gene protects kidneys from
ischaemia/reperfusion injury by suppressing pro-inflammatory activation. J Mol Med 2008; 86: 13291339.
35. De Groot, Harper L, Jayne DRW, Suarez LFF, Gregorini G, Gross WL, Luqmani R, Pusey CD,
Rasmussen N, Sinico R, Tesar V, Vanhille P, Westman K, Savage COS, for the EUVAS Group. Pulse
versus daily oral Cyclophosphamide for induction of remission in anti-neutrophil cytoplasmic antibodyassociated vasculitis. Ann Intern Med 2009; 150: 670-680.
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36. Gordon C, Jayne D, Pusey C, Adu D, Amoura Z, Aringer M, Ballerin J, Cervera R, Calvo-Alén J,
Chizzolini C, Dayer J, Doria A, Ferrario F, Floege J, Guillevin L, Haubitz M, Hiepe F, Houssiau F,
Lesavre P, Lightstone L, Meroni P, Meyer O, Moulin B, O'Reilly K, Praga M, Schulze-Koops H, Sinico
R, Smith K, Tincani A, Vasconcelos C, Hughes G. European consensus statement on the terminology
used in the management of lupus glomerulonephritis. Lupus 2009; 18: 257-263.
37. Buelli S, Abbate M, Morigi M, Moioli D, Zanchi C, Noris M, Zoja C, Pusey C, Zipfel P, Remuzzi G.
Protein load promotes complement dependent dysfunction of proximal tubular cells via impairment of
factor H regulation. Kidney Int 2009; 75: 1050-1059.
38. Taylor SRJ, Turner C, Hewitt R, McDaid J, Smith J, Elliott J, Pickering MC, Burnstock G, Pusey CD,
Unwin R, Tam F. P2X7-deficiency attenuates renal injury in experimental glomerulonephritis. J Am
Soc Nephrol 2009; 20: 1275-1281.
39. Taylor SRJ, Salama AD, Joshi L, Pusey CD, Lightman S. Rituximab is effective in the treatment of
refractory ophthalmic Wegener’s granulomatosis. Arth Rheum 2009; 60: 1540-1547.
40. Little M, Smyth L, Salama A, Mukherjee S, Smith J, Haskard DO, Nourshargh S, Cook T, Pusey CD.
Experimental autoimmune vasculitis: an animal model of ANCA-associated systemic vasculitis. Am J
Pathol 2009; 174: 1212-1220.
41. Reynolds J, Abbott DS, Karegli J, Evans DJ and Pusey CD. Mucosal tolerance induced by an
immunodominant peptide from rat α3(IV)NC1 in established experimental autoimmune
glomerulonephritis Am J Pathol 2009; 174: 2202-2210.
42. Tam FWK, Riser BL, Meeran K, Rambow J, Pusey CD, Frankel AH.
Urinary monocyte
chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers
for progression of diabetic nephropathy. Cytokine 2009; 47: 37-42.
43. Pepper R, Griffith M, Kirwan C, Levy J, Taube D, Pusey C, Lightstone L, Cairns T. Rituximab is an
effective treatment for lupus nephritis and allows a reduction in maintenance steroids. Nephrol Dial
Transplant 2009; 24: 3717-3723.
44. Annear NMP, Cook HT, Atkins M, Pusey CD, Salama AD. Non-hepatitis virus associated mixed
essential cryoglobulinaemia. Kidney Int 2010: 77: 161-164 (Epub Nov 09).
45. Smith J, McDaid JP, Bhangal G, Chawanasuntorapoj R, Masuda ES, Cook T, Pusey CD, Tam FWK.
A spleen tyrosine kniase inhibitor reduces the severity of established glomerulonephritis. J Am Soc
Nephrol 2010; 21: 231-236.
46. Nogueira E, Hamour S, Sawant D, Henderson S, Mansfield N, Chavele K-M, Pusey CD, Salama AD.
Serum IL-17 and IL-23 and autoantigen-specific Th17 cells are elevated in patients with ANCAassociated vasculitis. Nephrol Dial Transplant (Epub 210)
47. Taylor SRJ, Gonzalez-Begne M, Sojka DK, Richardson JC, Sheardown SA, Harrison SM, Pusey CD,
Tam FWK, Elliott JI. Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses. J
Leukoc Biol (in press).
48. Kamesh L, Heward JM, Williams JM, Gough SCL, Chavele K-M, Salama A, Pusey C, Savage COS,
Harper L. CT60 and +49 polymorphisms of CTLA-4 are associated with ANCA positive small vessel
vasculitis. Rheumatology (in press).
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