MATERIAL SAFETY DATA SHEET
Difenoconazole 25% EC
1.
IDENTIFICATION OF CHEMICAL PRODUCT AND COMPANY
PRODUCT NAME: Difenoconazole 25% EC
CHEMICAL NAME: N-((6-chloro-3-pyridinyl)methyl)-N'-cyano-N-methyl-ethanimidamide
CHEMICAL FORMULA: C19H17Cl2N3O3
MOLECULAR WEIGHT: 406.3
USAGE: Fungicide
MANUFACTURER & ADDRESS:
Jadesheen Chemical Co., Ltd
No. 123, Qi Gang Road, Shizhuang, JiangYin (214446), P.R.China
2.
COMPOSITION/INFORMATION ON INGREDIENT
Components
Difenoconazole
Inert Ingredients
3.
CAS Number
119446-68-3
--
%
25.0
75.0
HAZARD IDENTIFICATION
Acute
Toxicity: This product is unlikely to present a toxicity hazard during normal use (WHO Hazard
Class III)
Swallowed: Low toxicity
Dermal: Low toxicity
Absorption: Tests on rabbits indicate a low toxicity due to dermal contact with undiluted product.
Inhaled: Low toxicity
Irritation
Eye: Slight irritant
Skin: Non irritant
Sensitisation
Skin: Not a sensitiser
Poisoning symptoms: No case of human poisoning due to this product is on record. The
poisoning symptoms observed for laboratory mammals were non-specific.
Chronic: Difenoconazole technical has been extensively tested on mammals and in test-tube
systems. No evidence of mutagenic, teratogenic or reproductive effects was obtained. Chronic
2-year feeding studies revealed no compound-related tumourigenic effects in rats, whereas in mice
high doses were associated with an increased incidence of liver tumours. The absence of
mutagenic effects and the pronounced restriction of tumour appearance to one organ and one
species suggests an underlying promotion process which is frequently seen in mice and which is
considered to have no bearing in humans. Repeated high doses of difenoconazole technical were
associated with cataracts in dogs and hens. Studies on other species and a subsequent dog study
did not confirm this effect. Other effects at high doses included liver toxicity and adverse effects
on blood cells and platelets.
4.
FIRST AID MEASURES
Ingestion: If swallowed: Call a poison control center or doctor immediately for treatment advice.
Have the person sip a glass of water if able to swallow. Do not induce vomiting unless told to do
so after calling a poison control center or doctor. Do not give anything by mouth to an
unconscious person.
Eye Contact: If in eyes: Hold eye open and rinse slowly and gently with water for 15-20 minutes.
Remove contact lenses, if present, after 5 minutes, then continue rinsing eye. Call a poison control
center or doctor for treatment advice.
Skin Contact: If on skin or clothing: Take off contaminated clothing. Rinse skin immediately
with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice.
Inhalation: If inhaled: Move person to fresh air. If person is not breathing, call an ambulance,
then give artificial respiration, preferably mouth-to-mouth if possible. Call a poison control center
or doctor for further treatment advice.
Notes to Physician: There is no specific antidote if this product is ingested. Treat
symptomatically.
Medical Condition Likely to be Aggravated by Exposure: None known.
5.
FIRE FIGHTING MEASURES
Fire and Explosion
Flash Point (Test Method) : >210°F
Flammable Limits (% in Air): Upper: % Not Applicable Lower: % Not Applicable
Autoignition Temperature: Not Available
Unusual Fire, Explosion and Reactivity Hazards: During a fire, irritating and possibly toxic
gases may be generated by thermal decomposition or combustion.
In Case of Fire: Use dry chemical, foam or CO2 extinguishing media. Wear full protective
clothing and self-contained breathing apparatus. Evacuate nonessential personnel from the area to
prevent human exposure to fire, smoke, fumes or products of combustion. Prevent use of
contaminated buildings, area, and equipment until decontaminated. Water runoff can cause
environmental damage. If water is used to fight fire, dike and collect runoff.
Flammability: Not flammable
6.
ACCIDENTAL RELEASE MEASURES
Evacuation procedures and safety
Personnel handling this material should be thoroughly Control the spill at its source. Contain the
spill to prevent it from spreading, contaminating soil, or entering sewage and drainage systems or
any body of water. Clean up spills immediately, observing precautions outlined in Section 8. If a
solid, sweep up material and place in a compatible disposal container. If a liquid, cover entire spill
with absorbing material and place into compatible disposal container. Scrub area with hard water
detergent (e.g. commercial products such as Tide, Joy, Spic and Span). Pick up wash liquid with
additional absorbent and place into compatible disposal container. Once all material is cleaned up
and placed in a disposal container, seal container and arrange for disposition.
7.
HANDLING AND STORAGE
Store the material in a well-ventilated, secure area out of reach of children and domestic animals.
Do not store food, beverages or tobacco products in the storage area. Prevent eating, drinking,
tobacco use, and cosmetic application in areas where there is a potential for exposure to the
material. Wash thoroughly with soap and water after handling.
8.
EXPOSURE CONTROLS/PERSONAL PROTECTION
Ingestion: Prevent eating, drinking, tobacco usage and cosmetic application in areas where there
is a potential for exposure to the material. Wash thoroughly with soap and water after handling.
Eye Contact: Where eye contact is likely, use chemical splash goggles. Facilities storing or
utilizing this material should be equipped with an eyewash facility and a safety shower.
Skin Contact: Where contact is likely, wear chemical-resistant (such as nitrile or butyl) gloves,
coveralls, socks and chemical-resistant footwear. For overhead exposure, wear chemical-resistant
headgear.
Inhalation: Use process enclosures, local exhaust ventilation, or other engineering controls to
keep airborne levels below exposure limits. A NIOSH-certified combination air-purifying
respirator with an N, P or R 95 or HE class filter and an organic vapor cartridge may be
permissible under certain circumstances where airborne concentrations are expected to exceed
exposure limits. Protection provided by air-purifying respirators is limited. Use a pressure demand
atmosphere-supplying respirator if there is any potential for uncontrolled release, exposure levels
are not known, or under any other circumstances where air-purifying respirators may not provide
adequate protection.
9.
PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Liquid
pH: 5.0 – 8.0
Water content: ≤0.5%
Emulsion stability: Qualified
10. STABILITY AND REACTIVITY
Stability: Stable under normal use and storage conditions.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: None known.
Hazardous Decomposition Products: Can decompose at high temperatures forming toxic gases.
Materials to Avoid: Strong oxidizers.
11.
TOXICOLOGICAL INFORMATION
Acute Oral (LD50 Mice): > 2000mg/kg
Acute Dermal (LD50 Mice): > 4000mg/kg
Inhalation: Practically Non-Toxic. Inhalation (LC50 Rat): > 2.73 mg/l air - 4 hours
Eye and Skin Irritation: Can cause eye and skin irritation
Sensitivity: Don’t cause sensitivity
12. ECOLOGICAL INFORMATION
LC50 for Rainbow Trout (96h): 0.81mg/L
LC50 for Crucian Carp (96h): 1.2mg/L
LC50 for Bluegill (96h): 0.82mg/L
13. DISPOSAL CONSIDERATIONS
Disposal: Do not reuse product containers. Dispose of product containers, waste containers, and
residues according to local, state, and federal health and environmental regulations.
Characteristic Waste: Not Applicable
Listed Waste: Not Applicable
14. TRANSPORT INFORMATION
DOT Classification: Not regulated by DOT.
B/L Freight Classification: Fungicides, NOIBN, o/t poison
Comments: None.
15.
REGULATORY INFORMATION
R phrases: R22-43-50/53-39/23/24/25-23/24/25-11
S phrases: S36/37-46-60-61-45-16-7
16.
OTHER INFORMATION
STATEMENT NOTICE
The information and recommendations contained herein is believed to be reliable and are presented in
good faith by the supplier. The information is supplied upon the condition that users and handlers of the
product will make their own determination as to its suitability for their purpose prior to use. In no event
will the supplier be responsible for damages of any nature concerning the handling and use of this
product. Handlers and users of the product assume all risks and liabilities arising from its handling, use
or application.