ANIMAL CARE AND USE PROGRAM REVIEW FORM
SECTION 6A.
LABORATORY ANIMAL FACILITIES
This section must be completed for each laboratory animal facility and details the criteria used by the CCAC to
conduct site visits. Animal Care Committee (ACC) members should refer to CCAC guidelines and policies for further
information, in particular the CCAC guidelines on: laboratory animal facilities—characteristics, design and
development and the CCAC Guide to the Care and Use of Experimental Animals.
Animal Care Committee members must conduct a site visit of
the animal facility prior to completing this section
Name of the facility for which this section will be completed:
GENERAL INFORMATION
6A01.
a)
The manager of the animal facility:
Name and Title
(Dr., Mr., Ms., etc.):
Position:
Mailing address
City, Prov., Postal Code
,
,
Phone:
(
)
-
Fax number:
(
)
-
ext.
Email:
b)
6A02.
To whom does the manager of the animal facility report?
To whom does the animal care staff report?
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6A03.
Who is/are the veterinarian(s) responsible for the facility?
6A04.
a)
List of all Animal Care Committee (ACC) members who visited the facility:
b)
Name and position of other individuals who accompanied the ACC on its visit:
c)
Date of site visit (year/month/day):
/ /
6A05.
a)
Location of facility:
b)
Approximate surface area of the animal facility (imperial or metric):
square feet
c)
6A06.
square meters
Year of construction:
Please indicate the type of facility and purpose of use (check all that apply):
a)
Type(s) of facility:
Conventional
Inclusive barrier(s) (e.g. quarantine, biohazard, isolation)
Exclusive barrier(s) (e.g. breeding animals, Specific Pathogen Free)
Other (please specify):
b)
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Purpose(s) of use:
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Research
Regulatory testing
Teaching
Production
Other (please specify):
c)
Specialized area(s):
Aquatic areas (e.g. zebra fish, xenopus) – Please fill out Appendix I – Aquatic Animals in
a Small Scale Laboratory Setting
Aviaries – Please fill out Appendix II – Birds in a Laboratory Setting
Other (please specify):
6A07.
List the types of rooms (e.g. surgery suites, animal holding rooms, necropsy area, cage wash area,
laboratories) present in the animal facility:
6A08.
Indicate any improvements that have been made to this facility since the last CCAC visit:
N/A
6A09.
Comments or additional information concerning the adequacy of your facility, given the animal
model(s) used and the type of work conducted:
FACILITY MAINTENANCE
Please refer to Chapters II, III and IV of the CCAC Guide to the Care and Use of Experimental Animals, Volume 1.
General Infrastructure
6A10.
Is there a documented regular maintenance program in place for the facility and equipment?
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Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A11.
Are there contingency plans (SOPs) in place when equipment fails or is shut down for repairs?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A12.
Does the facility have an emergency contingency capacity (e.g. generator, other emergency
power supply) capable of maintaining critical life support systems (e.g. HVAC, ventilated
racks)?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A13.
Are critical pieces of equipment, such as fans and motors for the HVAC and ventilated racks,
duplicated to ensure that mechanical failures cause only minimal interruptions in service?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A14.
Are floors, walls, ceilings and other surfaces free of damage, impervious to water and easy to
clean and disinfect?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A15.
Are all wooden, concrete and other porous surfaces sealed?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
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6A16.
Are there door sweeps in place to prevent vermin entry and prevent escapes from animal holding
rooms?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A17.
Comments or additional information:
Environment
Ventilation
6A18.
Is the ventilation system checked regularly for its air exchange capacity and is it calibrated
regularly?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A19.
Indicate the date at which the ventilation system was last checked and provide a summary of
relevant results:
6A20.
What are the air changes per hour in the housing rooms?
6A21.
Are positive pressures being used to protect clean areas, immunodeficient animals and other animals
requiring high levels of protection, and are negative pressures being used in dirty/biohazardous
areas?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
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6A22.
Please provide any relevant details concerning the use of relative air pressures in the facility:
6A23.
Comments or additional information:
Temperature
6A24.
Can temperatures be adjusted in each room to suit the needs of each species held?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A25.
How frequently are temperatures in each room monitored?
by continuous recording
on a daily basis
less frequently (specify):
6A26.
Are records of temperatures kept and are they easily accessible?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A27.
Are safeguards in place to ensure a safe temperature range for each species?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
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6A28.
Comments or additional information:
Relative Humidity
6A29.
Is relative humidity maintained within an appropriate range for each species?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A30.
Are records of humidity levels kept?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A31.
How frequently are humidity levels monitored in each room?
by continuous recording
on a daily basis
less frequently (specify):
6A32.
Comments or additional information:
Light
6A33.
Is the light intensity adjusted in each room, particularly rodent rooms, according to the species
housed to prevent the harmful effects of elevated light intensity levels?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
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6A34.
Are light cycles appropriately controlled in each room according to the species housed?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A35.
Comments or additional information:
Noise
6A36.
Is noise well controlled within the facility?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A37.
Comments or additional information:
FACILITY MANAGEMENT
Housekeeping
6A38.
Is the facility clean and well organized?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A39.
a)
Program Review Form
Are there standard operating procedures (SOPs) in place for housekeeping and cleaning?
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Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
b)
Are there SOPs in place for the cleaning and sanitation of special areas such as surgery
suites, procedure areas and food preparation areas?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
c)
Are there SOPs in place for the disposal of waste materials such as dead animals, animal
tissues and excreta, bedding, and unused food?
Yes
Yes and No
No
N/A
Please elaborate if your answer is "Yes and No" or "No":
6A40.
When biological waste is stored, is it placed in a cold storage area provided for that purpose and
separated from other storage facilities?
Yes
Yes and No
No
N/A
Please elaborate if your answer is "Yes and No" or "No":
6A41.
How are cages, water bottles, etc. cleaned?
Automatic washing equipment
Other (specify):
6A42.
How is the efficacy of the washing and sanitization procedures monitored (e.g. bacteriological
analysis, temperature strips)?
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6A43.
Is dirty bedding dumped safely in a dumping station or separate area in order to prevent
aerosolization of particles and micro-organisms, health problems in personnel and contamination of
other areas in the facility?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A44.
Are chemical products (including cleaning products, disinfectants and industrial detergents) stored
appropriately?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A45.
Are animals kept safely away from cleaning products and pressure spraying procedures?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A46.
Is the storage space available in the facility sufficient to meet needs? (N.B. Animal holding rooms,
corridors, procedure rooms, surgery rooms, and other such rooms should not be used for storage
purposes.)
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A47.
Are clean cages stored in a separate area and kept off the floor?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A48.
Are food and bedding stored in dry, well-ventilated quarters, and is the food used within six months
of the milling date?
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Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A49.
Is there a vermin and pest control program in place, including in the loading dock/reception area for
animals, and in food and bedding storage areas?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A50.
Comments or additional information:
Controlled Substances
6A51.
Are controlled substances kept in a locked and secure area and are they safely disposed of after their
expiry date?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A52.
Provide the names and titles of personnel with access to controlled substances:
6A53.
Are records kept of the use of each substance?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A54.
Are inhalant anesthesia machines calibrated according to the manufacturer’s recommendations for
the anesthetic agents used?
Yes
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Yes and No
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No
N/A
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Please elaborate if your answer is "Yes and No" or "No":
6A55.
Are anesthetic gases appropriately evacuated or scavenged?
Yes
Yes and No
No
N/A
Please elaborate if your answer is "Yes and No" or "No":
6A56.
Are volatile compounds used under chemical hoods or with another appropriate scavenging system?
N/A
YES
Yes and No
NO
Please elaborate if your answer is "Yes and No" or "NO":
6A57.
Comments or additional information:
Microbiological Control
6A58.
Biosecurity refers to measures put in place to keep disease agents away from the animals and can
include the use of facility specific clothing, foot baths, disinfectant stations and relative air pressures,
for example.
Is an appropriate biosecurity program in place?
6A59.
Yes
Please describe current program
Yes and No
Please elaborate
No
Please elaborate
Is the traffic flow in the facility established from cleaner to dirtier areas to prevent crosscontamination?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
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6A60.
Are measures in place to prevent cross-contamination between the clean and dirty sides of the cage
wash area?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A61.
For exclusive barrier facilities/areas (SPF, breeding animals), describe the measures and practices in
place to reduce the probability of contamination beyond general measures already described in
question 6A58:
N/A
6A62.
For inclusive barrier facilities/areas (biohazard, quarantine, isolation), describe the measures and
practices in place to contain pathogens:
N/A
6A63.
a) Are floor drains cleaned regularly and provided with adequate cover and pitch basket traps as
needed?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
b) Are unused floor drains capped and sealed?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A64.
Comments or additional information:
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SECURITY OF THE FACILITY
6A65.
Describe the security measures in place for the animal facility, including access during and after
regular working hours:
6A66.
Are all access points to the facility secure?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A67.
Can some animal rooms be accessed directly from a public corridor?
Yes
Yes and No
No
Please elaborate if your answer is "Yes" or "Yes and No":
6A68.
Are all doors leading to the outside kept closed and locked at all times?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A69.
Can the public see inside any area of the animal facility?
Yes
Yes and No
No
Please elaborate if your answer is "Yes" or "Yes and No":
6A70.
Are emergency exits easily accessible and free of obstacles? Can all employees, including those
working in barrier areas, easily exit the building in case of fire or other emergency?
Yes
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Yes and No
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No
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Please elaborate if your answer is "Yes and No" or "No":
6A71.
Comments or additional information:
OCCUPATIONAL HEALTH AND SAFETY
6A72.
Are all electrical outlets protected?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A73.
Are all electrical outlets in wet areas ground fault circuit interrupter (GFCI)?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A74.
Are all electrical cables installed properly and kept out of reach?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A75.
Are the floors dry and non-slippery?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A76.
Are steps, differences in floor levels, the cage washer pit and other potential hazards well identified
to prevent accidents?
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Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A77.
Are protective wear and protective devices being used appropriately by staff members in the animal
facility?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A78.
Comments or additional information:
ANIMAL CARE AND WELFARE
General Information
6A79.
The following is a list of possible sources for acquiring animals. Indicate all animal species that are
used/housed in the facility according to their acquisition source:
a)
Laboratory animal suppliers, such as Charles River, Harlan, etc.
Please list species:
b)
City pounds, SPCA, and other animal shelters
Please list species:
c)
Small businesses selling animals
Please specify business and list species:
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d)
Provided by other institutions holding a CCAC Certificate of Good Animal Practice
Please list species:
e)
Other sources
Please specify source and list species:
6A80.
Identify all breeding colonies present in the facility, along with their protocol number:
N/A
6A81.
Identify any animals that are kept long-term (a year or more) in the facility and the purpose for
which they are kept:
N/A
Species
6A82.
Length of time kept Protocol
in facility
number
Purpose for which they are kept
Comments or additional information:
Identification and Records
6A83.
All animal cages should be identified with standardized ID cards that include the following
information. Please check all that apply at your facility:
date of arrival
species and sex
estimated age or weight
number of animals in cage
name of principal investigator and emergency contacts
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animal use protocol number, including expiration date
other special instructions as may be pertinent to their care
Please elaborate if any of these pieces of information are not included:
6A84.
Are complete and thorough health records available for all experimental animals and are these
records also kept for a period of one year after the final disposition of the animal?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A85.
Are complete and thorough records kept on all surgical procedures conducted on animals and on all
pre- and post-operative care?
N/A
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A86.
Are all SOPs for animal care, use and handling and facility management readily available to animal
care staff, research team members and any students within the animal facility?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A87.
Are all protocols readily available to animal care staff, research team members, students and any
other individuals working with animals, and is the information on endpoints and procedures easily
available within the facility?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A88.
Comments or additional information:
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Husbandry Practices
6A89.
a) Describe the source of water (e.g. municipal water, well water) provided to the animals and the
means of distribution (e.g. automatic, bottles). If water bottles are used, indicate how often they
are changed:
b) Describe how water quality is monitored:
c) How frequently is water quality monitored?
6A90.
Describe the type of bedding provided to the animals and how often it is changed:
6A91.
Describe the type of food provided to the animals and how it is stored:
6A92.
Is environmental enrichment provided to all the animals held in the facility?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A93.
Are different species always housed in separately ventilated units (e.g. rooms, ventilated racks,
cubicles)?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A94.
Are more invasive procedures on animals always conducted in separately ventilated areas?
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Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A95.
Are there SOPs in place for all animal husbandry practices?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A96.
Comments or additional information:
Animal Care
6A97.
Did all animals observed during the visit appear to be in good condition?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
6A98.
Were all animals observed during the visit provided with environmental enrichment?
Yes
Yes and No
No
Please elaborate if your answer is "Yes and No" or "No":
GENETICALLY- ENGINEERED ANIMALS
N/A
6A99.
If not applicable, go to the next section (Appendices).
Have all regulatory requirements relating to the importation, creation or use of organisms with
novel traits been met?
Yes
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Yes and No
No
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Please elaborate if your answer is "Yes and No" or "No":
6A100
Comments or additional information:
APPENDICES
Please provide the following appendices and use the checklist to indicate that they have in fact been included.
If you are not including one or more of the requested appendices, please briefly explain why for each.
Appendix 6A-A:
A copy of the floor plans of the animal facility.
Appendix 6A-B:
An example of your cage/pen/aquarium identification card(s) (filled in).
Appendix 6A-C:
An example of an animal health record (filled in).
Appendix 6A-D:
A copy of the last two site visit reports by your Animal Care Committee including
recommendations and follow-ups.
Additional Appendices (specify):
Please explain if you are excluding any of the requested appendices:
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