Jan 2010 Curriculum vitae & publications Abdul G. DULLOO Country of Birth: Permanent Residence: Language: Mauritius Switzerland English, French & Creole Current Position: Lecturer and research fellow (Privat docent, Maître d’enseignement et de recherche) Current Address: Department of Medicine - Division of Physiology Laboratory of Nutritional energetics & Body composition regulation University of Fribourg Rue du Musée 5, 1700 Fribourg, Switzerland e-mail: abdul.dulloo@unifr.ch University Education . 1976-1979 Bachelor (Bsc) degree in Physiology & Biochemistry, University of London, UK . 1979-1980 Post-graduate course in Human Nutrition, University of London, UK . 1980-1983 Doctoral (PhD) degree in Nutrition, University of London, UK Academic & Research Positions . University of London (U.K.) 1980-1983 1983-1985 . Harvard Medical School (U.S.A) 1986-1988 Department of Nutrition . Doctoral research student . Postdoctoral research assistant Endocrinology & Metabolism, Beth Israel Hospital, . Postdoctoral research fellow . University of Geneva (Switzerland) Faculty of Medicine, Dept. of Physiology 1988 -1993 1993 -1998 . Research associate . Teaching / research faculty . University of Fribourg (Switzerland) Department of Medicine, Division of Physiology From 1999 . Lecturer and research faculty 2. Scholarships & Student Awards University of London Bsc degree with distinction (1st class honours), 1979 British Council Scholarship for doctoral (PhD) studies, 1980-1983 Obesity Research Foundation Award (UK), 1983-1985 International Foundation for the Promotion of Nutrition Research Award, 1984-1985 Postdoctoral Research Fellowship - Harvard Medical School (USA), 1986-1988 Main Current Research Grants Swiss National Science Foundation (SNSF) RESEARCH SPECIALITY Thermogenesis, nutrient partitioning and body composition regulation CURRENT RESEARCH THEMES Molecular-physiological approaches for understanding: (i) the role of variations in metabolic efficiency (thermogenesis) in autoregulation of body weight and body composition, and (ii) the role of suppressed skeletal muscle thermogenesis in pathogenesis of the insulin resistance and cardiovascular risks . Main research topics : · Molecular mechanisms of adaptive thermogenesis and substrate metabolism from a perspective of system physiology · Impact of nutritionally-induced alterations in thermogenesis on the early development of insulin resistance and cardiovascular risks · Biocative food ingredients as modulators of thermogenesis, fat oxidation, insulin sensitivity and cardiovascular risks 3. CURRENT TEACHING . Lecturer in Physiology to Medical, Biomedical, Pharmacy & Sports students on topics of Nutrition and Dietetics Nutrition & metabolism (pertainining to chronic metabolic diseases) Physiology of Digestion Body weight regulation and obesity . Tutor APP (problem based learning) to medical students on topics of: Anaemia Sleep apnea . Colloquium coordinator to 2nd year medical Students on the topic: Cardivascular, respiratory and metabolic adaptations to acute exercise Gas exchange . Doctoral students / postdoctoral fellows (current) Doctoral student: Ms Helena Marcelino Project title: Adipose tissue plasticity during accelerated fat recovery (catch-up fat) with implications for pathogenic consequences of catch-up growth and obesity relapse Doctoral student: Mrs Gayathri Yepuri Project title: Dietary modulation of body composition and insulin sensitivity during catch-up growth: impact of fat types and protein types Doctoral student: Ms Delphine Sarafian Project title: Interactions between food and spontaneous physical activity on postprandial thermogenesis and substrate oxidation Doctoral student : Ms Sadhna Hunma Project title: Phenotyping for susceptibility to obesity and type 2 diabetes in young Mauritians: a population at high risk for metabolic syndrome Postdoctoral fellow / Research associate: Dr Jennifer Miles Project title: Molecular mechanisms of thermogenesis crosslinking with insulin signalling Dr Denis Arsenijevic Project title: Non-adrenergic activation of thermogenesis in brown adipose tissue 4. Conference Organisation Thermogenic drugs to assist the dietary treatment of obesity an international meeting held in Geneva on 24-26 September 1992. Proceedings Editor International Journal of Obesity : vol 17 (suppl. 1) 1993. Recovery from protein-energy malnutrition: Catch-up growth and nutritional rehabilitation International symposioum held in conjunction with the European Society of Parental and Enteral Nutrition (ESPEN) in September 1996 in Geneva, Switzerland. Proceedings Editor Clinical Nutrition vol 16 (suppl. 1) 1997. Molecular-physiological pathways to obesity and metabolic diseases Meeting of the 1st Fribourg Obesity Research Conference, FORC-2001, held on September 21st, 2001 in Fribourg, Switzerland. Proceedings editor International Journal of Obesity vol 26 (suppl. 2) 2002 Molecular-physiological pathways to ectopic fat storage, lipotoxicity and metabolic diseases Meeting of the 2nd Fribourg Obesity Research Conference, FORC-2003, to be held on October 3rd , 2003 in Fribourg, Switzerland. Proceedings editor – International Journal of Obesity vol 28 (suppl 4) 2004 Growing into obesity and the metabolic syndrome: from a perspective of molecular physiology and nutrition. Meeting of the 3rd Fribourg Obesity Research Conference, FORC-2005, to be held on September 30th , 2005 in Fribourg, Switzerland. Proceedings editor – International Journal of Obesity vol 30 (suppl4 ) 2006 Dysfunctional foods in pathways to obesity and metabolic syndrome: from a perspective of molecular physiology and nutrition. Meeting of the 4rd Fribourg Obesity Research Conference, FORC-2007, held on September 14th , 2007 in Fribourg, Switzerland. Proceedings editor – planned for publication in International Journal of Obesity in summer 2008 Phenotyping for early predictors of obesity and metabolic syndrome. Meeting of the 5th Fribourg Obesity Research Conference, FORC-2009, held on September 4th, 2009 in Fribourg, Switzerland. Proceedings editor – planned for publication in International Journal of Obesity in 2010 Academic Committees (current): Swiss Association for study obesity (ASEMO) – executive committee member Biennial Fribourg Obesity Research Conference (FORC) – organising committee member European Association for Study of obesity – scientific ECO committee member International Journal of Obesity: editorial board member 5. List of Publications Original Reports (peer-reviewed) 1. Dulloo AG and Miller DS. Thermogenic drugs for the treatment of obesity: sympathetic stimulants. British Journal of Nutrition 52: 179-197 (1984). 2. Dulloo AG and Miller DS. Energy balance following sympathetic denervation of brown adipose tissue. Canadian Journal of Physiology & Pharmacology 62: 235-240 (1984). 3. Dulloo AG and Miller DS. Unimpaired thermogenic response to noradrenaline in genetic (ob/ob) and hypothalamic (MSG) obese mice. Bioscience Reports 4: 343-349 (1984). 4. Dulloo AG and Miller DS. Increased body fat due to elevated energetic efficiency following chronic administration of inhibitors of sympathetic nervous system activity. Metabolism 34: 1061-1065 (1985). 5. Dulloo AG, Eisa O, Miller DS and Yudkin J. A comparative study of the effects of white sugar, unrefined sugar and starch on the efficiency of food utilisation and thermogenesis. American Journal of Clinical Nutrition 42: 214-219 (1985). 6. Ismail MN, Dulloo AG and Miller DS. Genetic and dietary influences on the levels of dietinduced thermogenesis and energy balance in adult mice. Annals of Nutrition & Metabolism 30: 189-195 (1986). 7. Dulloo AG and Miller DS. The effect of parasympathetic drugs on energy expenditure: relevance to the autonomic hypothesis. Canadian Journal of Physiology & Pharmacology 64: 586-591 (1986). 8. Dulloo AG and Miller DS. The thermogenic properties of ephedrine/methylxanthines mixtures: animal studies. American Journal of Clinical Nutrition 43: 388-394 (1986). 9. Dulloo AG and Miller DS. The thermogenic properties of ephedrine/methylxanthine mixtures: Human studies. International Journal of Obesity 10: 467-481 (1986). ** 10. Dulloo AG and Miller DS. Screening of drugs for thermogenic anti-obesity properties: antidepressants. Annals of Nutrition & Metabolism 31: 69-80 (1987). 11. Dulloo AG and Miller DS. Prevention of genetic fa/fa obesity with an ephedrine/methylxanthines thermogenic mixture. American Journal of Physiology 252: R507-513 (1987). 12. Dulloo AG and Miller DS. Reversal of obesity in genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture. Journal of Nutrition 117: 383-389 (1987). 13. Dulloo AG and Miller DS. Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity. American Journal of Clinical Nutrition 45: 564-569 (1987). 14. Dulloo AG, Ismail-Noor M, Ryall M, Melas G, Geissler CA and Miller D.S. - A low-budget and easy-to-operate room respirometer for the measurement of daily energy expenditure in man. American Journal of Clinical Nutrition 48: 1367-74 (1988). ** 6. 15. Dulloo AG, Young JB and Landsberg L. Sympathetic nervous system responses to cold exposure and diet in rat skeletal muscle. American Journal of Physiology 255: E180-E188 (1988). 16. Dulloo AG, Geissler C, Horton T, Collins A and Miller DS. Normal Caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and post-obese humans. American Journal of Clinical Nutrition 49: 44-50 (1989). ** 17. Dulloo AG and Miller DS. Ephedrine, Caffeine and Aspirin: "over-The-Counter" drugs that interact to stimulate thermogenesis in the obese. Nutrition 5: 7-9 (1989). 18. Dulloo AG and Girardier L. Energy expenditure and diet-induced thermogenesis in presence and absence of hyperphagia induced by insulin. American Journal of Physiology 257: R717-725 (1989). 19. Lowell BB, Napolitano A, Usher P, Dulloo AG, Rosen BS, Spiegelman B and Flier JS. Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimeticthermogenic drug mixture ephedrine and caffeine. Endocrinology 126: 1514-1520 (1990). 20. Dulloo AG and Girardier L. Adaptive changes in energy expenditure during refeeding following low calorie intake: evidence for a specific metabolic component favouring fat storage. American Journal of Clinical Nutrition 52: 415-420 (1990). 21. Dulloo AG, Seydoux J and Girardier L. Role of corticosterone in adaptive changes in energy expenditure during refeeding after low calorie intake. American Journal of Physiology 259: E658E664 (1990). 22. Krieger DR, Daly PA, Dulloo AG, Ransil BJ, Young JB and Landsberg L. Ephedrine, caffeine and aspirin promote weight loss in obese human subjects. Transactions of the Association of American Physicians 104: 307-312 (1990). ** 23. Dulloo AG and Young JB. Effects of monosodium glutamate and gold-thioglucose on dietary regulation of sympathetic nervous system activity in rodents. Metabolism 40: 113-121 (1991). 24. Dulloo AG and Calokatisa R. Adaptation to low calorie intake in obese mice: contribution of a metabolic component to diminished energy expenditures during and after weight loss. International Journal of Obesity 15: 7-16 (1991). 25. Dulloo AG, Seydoux J and Girardier L. Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. International Journal of Obesity 15: 317-326 (1991). 26. Chang HR, Dulloo AG, Vladoianu IR, Piguet PF, Arsenijevic D, Girardier L and Pechere JC. Fish oil decreases natural resistance of mice to infection with salmonella typhimurium. Metabolism 41: 1-2 (1992). 27. Chang HR, Arsenijevic D, Vladoianu IR, Pechere JC, Piguet PF, Girardier L and Dulloo AG. Dietary supplementation with fish oil enhances in vivo synthesis of tumour necrosis factor. Immunology Letters 34: 13-18 (1992). 28. Dulloo AG and Girardier L. Influence of dietary composition on energy expenditure during recovery of body weight in the rat: Implications for catch-up growth and obesity relapse. Metabolism 41: 1336-1342 (1992). 29. Dulloo AG, Seydoux J and Girardier L. Potentiation of the thermogenic anti-obesity effects of ephedrine by dietary methylxanthines: Adenosine antagonism or phosphodiesterase inhibition Metabolism 41: 1233-1241 (1992). 7. 30. Dulloo AG and Girardier L. 24h energy expenditure several months after weight loss in the underfed rat: evidence for a chronic increase in whole-body metabolic efficiency. International Journal of Obesity 17: 115-123 (1993). 31. Daly P, Krieger D, Dulloo AG, Young JB and Landsberg L. Ephedrine, caffeine and aspirin: safety and efficacy for the treatment of human obesity. International Journal of Obesity 17, suppl 1: S73-78 (1993). ** 32. Dulloo AG and Girardier L. Adaptive role of energy expenditure in modulating body fat and protein deposition during catch-up growth after early undernutrition. American Journal of Clinical Nutrition 58: 614-21 (1993). 33. Dulloo AG, Decrouy A and Chinet A. Suppression of Ca2+-dependent heat production in mouse skeletal muscle by high fish oil consumption. Metabolism 43: 931-934 (1994). 34. Dulloo AG, Seydoux J and Girardier L. Paraxanthine (the main metabolite of caffeine) mimics the interaction between caffeine and the sympathetic control of thermogenesis. American Journal of Physiology 30: E801-E804 (1994). 35. Dulloo AG, Mensi N, Seydoux J and Girardier L. Differential effects of high-fat diets varying in fatty acid composition on the efficiency of lean and fat tissue deposition during weight recovery after low food intake. Metabolism 44: 273-279 (1995). 36. Chang HR, Arsenijevic D, Vladoinau IR, Girardier L and Dulloo AG. Fish oil enhances macrophage Tumour necrosis factor- mRNA expression at the transcriptional level. Metabolism 44: 800-805 (1995). 37. Moinat M, Deng C, Muzzin P, Assimacopoulos-Jeannet F, Seydoux J, Dulloo AG and Giacobino JP. Modulation of obese gene expression in rat brown and white adipose tissues. FEBS Letters 373: 131-134 (1995). 38. Dulloo AG, Seydoux J and Girardier L. Dissociation of enhanced efficiency of fat deposition during weight recovery from sympathetic control of thermogenesis. American Journal of Physiology 269: R365-R369 (1995). 39. Dulloo AG, Fathi M, Mensi N and Girardier L. 24-hour energy expenditure and urinary catecholamines of humans consuming low-to-moderate amounts of medium-chain-triglycerides: a dose-response study using a human respiratory chamber. European Journal of Clinical Nutrition 50: 152-158 (1996) ** 40. Dulloo AG, Shahkhalili Y, Atchou G, Mensi N, Jacquet J and Girardier L. Dissociation of systemic GH-IGFI axis from a genetic basis of short stature in African Pygmies. European Journal of Clinical Nutrition 50: 371-380 (1996) ** 41. Dulloo AG, Jacquet J and Girardier L. Autoregulation of body composition during weight recovery in human: The Minnesota Experiment revisited. International Journal of Obesity 20: 393-405 (1996) ** 42. Dulloo AG, Jacquet J and Girardier L. Post-starvation hyperphagia and body fat overshooting in human: a role for feedback signals from lean and fat tissues. American Journal of Clinical Nutrition 65: 717-723 (1997) 43. Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo AG, Seydoux J, Muzzin P and Giacobino JP. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Letters 408: 39-42 (1997) 8. 44. Boss O, Samec S, Dulloo AG, Seydoux J, Muzzin P and Giacobino JP. Tissue-dependent upregulation of rat uncoupling protein-2 (UCP2) expression in response to fasting or cold. FEBS Letters 412: 111-114 (1997). 45. Revelli JP, Preitner F, Samec S, Muniesa P, Kuehne F, Vassalli JD, Dulloo AG, Seydoux J, Giacobino JP, Huarte J and Ody C. Targeted gene disruption reveals a leptin-independent role for mouse ß3-adrenoceptor in the regulation of body composition. Journal of Clinical Investigation 100: 1098-1106 (1997) 46. Arsenijevic D, Girardier L, Seydoux J, Chang HR and Dulloo AG. Altered regulation of energy balance and cytokine gene expression in a murine model chronic toxoplasmosis. American Journal of Physiology 272: E908-E917 (1997). 47. Arsenijevic D, Girardier L, Seydoux J, Pechere JC, Garcia I, Chang HR and Dulloo AG. Metabolic and cytokine responses to a second immunological challenge with LPS in mice with chronic Toxoplasma gondii infection. American Journal of Physiology 274: E439-E445 (1998). 48. Dulloo AG and Jacquet J. Adaptive reduction in basal metabolic rate in response to food deprivation in human: a role for feedback signal from the fat stores. American Journal of Clinical Nutrition 68: 599-606 (1998) ** 49. Samec S, Seydoux J and Dulloo AG. Role of UCP gene homologues in rat skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate ? The FASEB Journal 12: 715-724 (1998). 50. Samec S, Seydoux J and Dulloo AG. Inter-organ signaling between adipose tissue metabolism and skeletal muscle UCP homologues: Is there a role for circulating FFA ? Diabetes 47: 16931698 (1998) 51. Samec S, Seydoux J and Dulloo AG. Post-starvation gene expression of skeletal muscle UCP2 and UCP3 in response to dietary fat levels and fatty acid composition : A link with insulin resistance. Diabetes 48: 436-441 (1999) 52. Samec S, Seydoux J and Dulloo AG. Skeletal muscle UCP3 and UCP2 in response to inhibition of free fatty acid flux through mitochondrial -oxidation. European Journal of Physiology 438: 452-457 (1999) 53. Cadenas S, Buckingham JA, Samec S, Seydoux J, Din N, Dulloo AG and Brand M. UCP2 and UCP3 rise in starved muscle but mitochondrial proton conductance is unchanged. FEBS Letters 462: 257-260 (1999) 54. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P and Vandermander J. Efficacy of a green tea extract rich in catechin-polyphenols and caffeine in increasing 24h energy expenditure and fat oxidation in human. American Journal of Clinical Nutrition 70: 1040-1045 (1999). ** 55. Dulloo AG and Jacquet J. The control of partitioning between protein and fat during human starvation: its internal determinants and biological significance. British Journal of Nutrition 82: 339-356 (1999). ** 56. Dulloo AG and Jacquet J. Low-protein overfeeding: a tool for unmasking susceptibility to obesity in humans. International Journal of obesity 23: 1118-1121(1999). ** 9. 54. Samec S, Seydoux J and Dulloo AG. Downregulation of skeletal muscle UCP3 gene expression in response to refeeding is abolished by exposure to cold. Pflügers Arch (European Journal of Physiology) 439: 723-729 (2000). 55. Dulloo AG, Seydoux J, Girardier L, Chantre P and Vandermander J. Green tea and thermogenesis: Interactions between catechin-polyphenols, caffeine and sympathetic activity. International Journal of obesity 24: 252-258 (2000) 56. Arsenijevic D, Garcia I, Vesin C, Vesin D, Arsenijevic Y, Seydoux J, Girardier L, Ryffel B, Dulloo AG and Richard D. Differential roles of tumor necrosis factor- and interferon- in mouse hypermetabolic and anorectic responses induced by LPS. European Cytokine Network 11: 662668 (2000). 57. Van der Lee KAJM, Willemsen PHM, Samec S, Seydoux J, Dulloo AG, Pelsers MAL, Glatz JFC, Van der Vusse GJ and Van Bilsen M. Fasting-induced changes in the expression of genes controlling substrate metabolism in the heart Journal of Lipid Research 42: 1752-1758 (2001) 58. Iossa S, Lionetti L, Mollica MP, Crescenzo R, Botta M, Samec S, Dulloo AG and Liverini G. Differences in proton leak kinetics, but not in UCP3 protein content, in subsarcolemmal and intermyofibrillar skeletal muscle mitochondria from fed and fasted rats. FEBS Letters 505: 53-6 (2001). 59. Dulloo AG, Stock MJ, Solinas G, Boss O, Montani JP and Seydoux J. Leptin directly stimulates thermogenesis in skeletal muscle: role of PI-3 kinase. FEBS Letters 515: 109-113 (2002) 60. Samec S, Seydoux J, Russell A, Montani JP and Dulloo AG. Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPAR and key enzymes of lipid oxidation. Pflügers Arch (European Journal of Physiology) 445: 80-86 (2002) 61. Iossa S, Mollica MP, Lionetti L, Crescenzo R, Botta M, Samec S, Solinas G, Mainieri D, Dulloo AG and Liverini G. Skeletal muscle mitochondrial efficiency and uncoupling protein 3 in overeating rats with increased thermogenesis. Pflügers Arch (European Journal of Physiology) 445: 431-436 (2002) 62. Antic V, Dulloo AG and Montani JP. Short-term (5-day) changes in food intake alter daily haemodynamics in rabbits. American Journal of Hypertension 16: 302-306 (2003) 63. Crescenzo R, Mainieri D, Solinas G, Montani JP, Seydoux J, Liverini G, Iossa S, Dulloo AG. Skeletal muscle mitochondrial oxidative capacity and uncoupling protein 3 are differently influenced by semistarvation and refeeding. FEBS Letters 544: 138-142 (2003) 64. Crescenzo R, Samec S, Antic V, Rohrer-Jeanrenaud F, Seydoux J, Montani JP and Dulloo AG. A role for suppressed thermogenesis favouring catch-up fat in the pathophysiology of catch-up growth. Diabetes 52: 1090-1097 (2003) 65. Solinas G, Summermatter S, Mainieri D, Gluber M, Pirola L, Wymann MP, Rusconi S, Montani JP, Seydoux J, Dulloo AG. The direct effects of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation FEBS letters 577: 539-544 (2004) 66. Cettour-Rose P, Samec S, , Russell AP, Summermatter S, Mainieri, Carrillo-Theander C Montani JP, Seydoux J, Rohner-Jeanrenaud F, Dulloo AG. Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: A link between catch-up growth and later metabolic syndrome. Diabetes 54: 751-756 (2005) 10. 67. Brown C, Barberini L, Dulloo AG, Montani JP. Cardiovascular responses to water drinking in humans - does osmolality play a role? Am J Physiol 289: R1687-92 (2005) ** 68. Solinas G, Summermatter S, Mainieri D, Gluber M, Montani JP, Seydoux J, Smith SR, Dulloo AG. Corticotropin-releasing hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation. Endocrinology 147: 31-38(2006) 69. Brown C, Dulloo AG, Montani JP. Water-induced thermogenesis reconsidered - the effects of osmolality and water temperature on energy expenditure after drinking. J Clin Endo Metab 91: 3598-602 (2006) ** 70. Crescenzo R, Lionetti L, Mollica MP, Ferraro M, D'Andrea E, Mainieri D, Dulloo AG, Liverini G, Iossa S. Altered skeletal muscle subsarcolemmal mitochondrial compartment during catch-up fat after caloric restriction. Diabetes 55: 2286-93 (2006). 71. Feillet CA, Ripperger JA, Magnone MC, Dulloo AG, Albrecht U, Challet E. Lack of food anticipation in Per2 mutant mice. Curr Biol. 16: 2016-22 (2006). 72. Mainieri D, Summermatter S, Seydoux S, Montani JP, Rusconi S, Russell AP, Boss O, Buchala AJ, Dulloo AG. A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis. FASEB J 20: 1751-3 (2006) 73. Mainieri D, Montani JP, Seydoux J, Giacobino JP, Boss O, Dulloo AG. -adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis. Int J Obesity 31: 378-81 (2007). 74. Zanchi A, Dulloo AG, Perregaux C, Montani JP, Burnier M. Telmisartan prevents the glitazoneinduced weight gain without interfering with its insulin-sensitizing properties. Am J Physiol Endocrinol Metab; 293(1):E91-5. (2007). 75. Ayer A, Antic V, Dulloo AG, Van Vliet BN, Montani JP. Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist. Am J Physiol Heart Circ Physiol.;293(2):H1265-72 (2007) 76. Summermatter S, Mainieri D, Russell AP, Seydoux J, Montani JP, Buchala A, Solinas G, Dulloo AG. Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase. FASEB J.22: 774-85, 2008) 77. Brown CM, Dulloo AG, Yepuri G, Montani JP.Fructose ingestion acutely elevates blood pressure in healthy young humans. Am J Physiol Regul Integr Comp Physiol. 294: R730-7, (2008). ** 78. Summermatter S, Marcelino H , Arsenijevic D, Buchala A, Aprikian O, AssimacopoulosJeannet F, Seydoux J, Montani JP, Solinas G, Dulloo AG. Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: Relevance for muscle-adipose glucose redistribution during catch-up growth. Diabetes 58: 2228-2237 (2009) 79. Aubert G, Burnier M, Dulloo AG, Perregaux C, Mazzolai L, Pralong F, Zanchi A. Neuroendocrine characterization of telmisartan in dietr- and glitazone-induced weight gain. Metabolism 59: 25-32 (2010) 11. 80. Crescenzo R, Bianco F, Falcone I, Prisco M, Dulloo AG, Liverini G, Iossa S. Hepatic mitochondrial energetics during catch-up fat after caloric restriction. Metabolism (2010, in press) Invited Reviews, Symposium papers & Book chapterss 81. Miller DS and Dulloo AG. The experimental use of drugs for treating obesity. In Bender & Brookes (eds): Body Weight Control, Pitman, London, (1986). 82. Dulloo AG and Miller DS. Obesity: a disorder of the sympathetic nervous system. World Review of Nutrition & Dietetics 50: 1-56 (1987). 83. Dulloo AG. Stimulation of thermogenesis in the treatment of obesity: a rational approach. Journal of Obesity & Weight Regulation 7: 131-143 (1988). 84. Dulloo AG, Seydoux J and Girardier L. Dietary and pharmacological effectiveness of thermogenic stimulation in obesity treatment. In Y.Oomura et al. (eds): Progress in Obesity Research 1990, John Libbey & Company Ltd, pp135-144 (1991). 85. Dulloo AG. Thermogenic effects of coffee in man: a review. In F.O.S.A.N. (Foundazione per lo studio degli alimenti e della nutrizione) publications, decoffea 2, pp 1-5 (1991); idem Clin. Dietol. 19: 281-287 (1992). 86. Dulloo AG. The search for sympathomimetic drugs with thermogenic anti-obesity properties. In Current Topics in Pharmacology 1: 9-15 (1992). 87. Dulloo AG. Ephedrine, xanthines and prostaglandin-inhibitors: Actions and interactions in the stimulation of thermogenesis. International Journal of Obesity 17: suppl 1: S35-S40 (1993). 88. Dulloo AG, Seydoux J and Girardier L. Energy Adaptation and Obesity. In Proceedings of the 6th Asian Congress of Nutrition, Sept. 1991 (ed. Chong Yoon Hin et al.), Kuala Lumpur, Academe Art & Printing Services, pp 266-272 (1992). 75. Dulloo AG. Strategies to counteract re-adjustments towards lower metabolic rates during obesity management. Nutrition 9: 366-372 (1993). 76. Dulloo AG and Girardier L. Prédisposition à l'obésité : un avantage évolutif devenu nocif. Médecine et Hygiène 51: 2310-2314 (1993). 77. Pichard C, Slosman D and Dulloo AG. Muscle intracellular ions during malnutrition and refeeding. In Metabolic Support of the Critically Ill Patient (ed. Wilmore DW and Carpentier YA), Springer-Verlag, pp 62-81 (1993). 78. Dulloo AG, Henry CJK, Ismail MN, Jacquet J and Girardier L. Predisposition to human obesity: an evolutionary advantage turned deleterious. International Journal of Food Science & Nutrition 45: 159-168 (1994). 79. Pichard C, Kayser B and Dulloo AG. Chronic malnutrition with reference to muscle tissue. In Amino-acids Metabolism in Health and Nutritional Diseases, (ed. Cynober L), CRC Press, New York, pp 257-268 (1995). 80. Dulloo AG. Hurdles and hopes in the management of human obesity. In Proceedings of the 1st Scientific Obesity meeting, Malaysian Society for the study of Obesity, April 1995, Kuala Lumpur, Malaysia, edited by MN Ismail (1996). 81. Dulloo AG. Dietary fats and obesity: the "MCT factor". In Proceedings of the 1st Scientific Obesity meeting, Malaysian Society for the Study of Obesity, April 1995, Kuala Lumpur, Malaysia, edited by MN Ismail (1996). 12. 82. Dulloo AG. Regulation of body composition during weight recovery: Integrating energypartitioning and thermogenesis. Proceedings of a satellite symposium of ESPEN Congress (Geneva, 1996) on “Recovery from protein-energy malnutrition (PEM): catch-up growth in children and weight regain in adults” published in Clinical Nutrition 16 (suppl. 1): 25-35 (1997) 83. Dulloo AG. Human pattern of food intake and fuel-partitioning during weight recovery after starvation: A theory of autoregulation of body composition - British Nutrition Society 1996 Summer Symposium on ‘Mechanisms of Caloric Compensation’ - published in The Proceedings of The Nutrition Society 56: 25-40 (1997). 84. Chang HR, Dulloo AG and Bistrian B. Role of cytokines in AIDS Wasting Syndrome. Nutrition 14: 853-863 (1998) 85. Dulloo AG. Plant extracts that increase energy expenditure. Cahiers de Phytothérapie No. 2: 913 (1999). 86. Dulloo A.G. Phytomedicine for thermogenic stimulation in obesity management : potentials and limitations. In Functional Foods I: Claims and Evidence; edited by J. Buttriss and M. Saltmarsh; published by the Royal Society of Chemistry: pp 151-158 (2000). 87. Dulloo AG and Samec S. Uncoupling proteins: Do they have a role in body weight regulation ? Presented at 1999 meeting of North American Association for the Study of Obesity (NAASO), Charleston, USA. Published in: News in Physiological Sciences, NIPS 15:313-318 (2000). 88. Dulloo AG and Samec S. Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered. British Journal of Nutrition 86: 123-139 (2001) 89. Dulloo AG, Samec S, Seydoux J. Uncoupling protein 3 and fatty acid metabolism. Symposium of the Biochemical Society on Mitochondrial Uncoupling proteins’, July 10-13, 2001,Trinity college, Dublin, Ireland. Biochemical Society Transactions 29: 785-791 (2001) 90. Dulloo AG and Jacquet J. An adipose-specific control of thermogenesis in body weight regulation. Presented at the 3rd Donald B. Brown Chair on Obesity Symposium - The Ponderostat: from behaviour to neural substrates; Nov. 2000; Québec, Canada. Published in : International journal of Obesity 25 (Suppl. 5): S22-S29 (2001). 91. Dulloo AG and Jacquet J. Towards understanding the genetic basis of human susceptibility to obesity: a systemic approach. In ‘Obesity in Childhood and Adolescence’, edited by C. Chen and WH Dietz. Nestlé Nutrition Workshop Series, Pediatric Program, vol 49, p 143-159 (2002) 92. Montani JP, Antic V, Yang Z, Dulloo AG. Pathways from obesity to hypertension: from the perspective of a vicious triangle. International Journal of Obesity 26 (suppl 2): S28-S38 (2002). 93. Dulloo AG, Jacquet J and Montani JP. Pathways from weight fluctuations to metabolic diseases: focus on maladaptive thermogenesis and catch-up fat. Symposium paper read at the Fribourg Obesity Research Conference, September 2001, Fribourg, Switzerland. To be published in : International Journal of Obesity 26 (suppl 2): S46-S57 (2002). 94. Dulloo AG and Jacquet J. Adaptive thermogenesis is important in the aetiology of human obesity: The case for. In Progress in Obesity Research: 9; edited by G. Madeiros-Neto, A. Halpern and C. Bouchard. John Libbey & Co., Hampshire, UK; pp 708-712 (2003). 95. Antic V, Dulloo AG, Montani JP. Multiple mechanisms involved in obesity-induced hypertension. Heart, Lung and Circulation 12: 84-93 (2003) 96. Dulloo AG. Dietary supplements and herbal ingredients. In Pharmacotherapy of Obesity; edited by KG Hofbauer, U Keller & O Boss, CRC Press (Taylor & Francis), Florida, pp405-419 (2004) 13. 97. Dulloo AG, Seydoux J and Jacquet J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiology and Behaviour 83:587-602 (2004) 98. Dulloo AG, Antic V, Montani JP: Ectopic fat stores: housekeepers that can overspill into weapons of lean body mass destruction. International Journal of Obesity 28 (Suppl.4): S1-S2 (2004) 99. Dulloo AG, Gubler M, Montani JP, Seydoux J, Solinas G. Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity. International Journal of Obesity 28 (Suppl. 4): S29-S37 (2004) 100. Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG. Ectopic fat storage in heart, blood vessels and kidneys in pathogenesis of cardiovascular diseases. International Journal of Obesity 28 (Suppl. 4): S58-S65 (2004) 101. Dulloo AG. Energy balance and body weight homeostasis. In Clinical Obesity in Adults and Children, 2nd edition, edited by Peter G Kopelman, Ian D Caterson and William H Dietz; Blackwell Publishing, Oxford UK: pp 67-80 (2005) 102. Dulloo AG and Jacquet J. Energy adaptation. In Encyclopedia of Human Nutrition, 2nd edition; edited by B. Caballero, L. Allen and A. Prentice; Elsevier Ltd, pp 131-138, (2005) 103. Dulloo AG. A role for suppressed skeletal muscle thermogenesis in pathways from weight fluctuations to insulin resistance syndrome. Acta Physiologica Scandinavica 184:295-307 (2005) 104. Dulloo AG and Schutz Y. Energy balance and body weight regulation. In Human Nutrition and Dietetics, 11th edition, edited by Geissler CA and Powers HJ; Elsevier Ltd, London UK (2005) 105. Dulloo AG. Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity. Hormone Research 65, Suppl 3: 90-7 (2006) 106. Dulloo AG, Jacquet J, Seydoux J, Montani JP. The thrifty ‘catch-up fat’ phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome. International Journal of Obesity 30: S23-S35 (2006) 107. Montani JP, Viecelli AK, Prévot A, Dulloo AG. Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the 'repeated overshoot' theory. International Journal of Obesity 30: S58-S66 (2006) 108. Dulloo AG. Adaptive thermogenesis and substrate cycling in skeletal muscle. In Progress in Obesity Research: 10; Proceedings of the 10th International Congress on Obesity, September 2006 Sydney, Australia 109. Dulloo AG. Neuro-hormonal control of thermogenesis by adipokines. In Progress in Obesity Research: 10; Proceedings of the 10th International Congress on Obesity, September 2006 Sydney, Australia 110. Dulloo AG. Suppressed thermogenesis as a cause for resistance to slimming and obesity rebound: adaptation or illusion? Int J Obes (Lond). 31: 201-3 (2007). 111. Brown CM, Dulloo AG, Montani JP. Sugary drinks in the pathogenesis of obesity and cardiovascular diseases. Int J Obes (Lond) 32 (Suppl 6):S28-34 (2008). 112. Dulloo AG. Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance. Best Pract Res Clin Endocrinol Metab 22: 155-71 (2008). 14. 113. Dulloo AG. Biology of Obesity: Energy balance and body weight homeostasis – Chapter 6. In Clinical Obesity, 3rd edition, edited by Kopelman PG, Caterson I and Dietz W; Blackwell Publishing Ltd (Oxford, UK) (2009) 114. Dulloo AG and Schutz Y. Energy balance and body weight regulation. In Human Nutrition and Dietetics, 12th edition, edited by Geissler CA and Powers HJ; Elsevier Limited (UK) (2010, in press). Invited Editorials, Commentary & Perspectives 115. Dulloo AG. Caffeine, metabolic rate and obesity The Nutrition Report 8: 25 & 32 (1990). 116. Dulloo AG and Stock MJ. Ephedrine, xanthines, aspirin and other thermogenic drugs to assist dietary treatment of obesity. International Journal of Obesity 17 sup 1: S1-S2 (1993). 117. Dulloo AG. Coffee and Health. European Journal of Clinical Nutrition 49: 225-226 (1995). 118. Dulloo AG. Medium-Chain-Triglycerides and weight control European Journal of Clinical Nutrition 51: 714-715 (1997). 119. Dulloo AG. Partitioning between protein and fat during starvation and refeeding: is the assumption of intra-individual constancy of P-ratio valid ? British Journal of Nutrition 79: 107-109 (1998). 120. Dulloo AG. Spicing fat for combustion British Journal of Nutrition 80: 493-494 (1998). 121. Dulloo AG. UCP2 and UCP3 : genes for thermogenesis or lipid handling ? Obesity Matters vol. 2 (no.1): 5-8 (1999). 122. Dulloo AG. Regulation of food intake and energy expenditure British Journal of Nutrition 83: 681-682 (2000). 123. Dulloo AG. Modulation of obesity by a green tea catechin American Journal of Clinical Nutrition 72: 1233-4 (2000). 124. Dulloo AG. Simulation of herbal ephedrine and caffeine in treatment of obesity International Journal of Obesity 26: 590-592 (2002). 125. Dulloo AG, Antic V and Montani JP. Pathogenesis of the worst killers of the 21st century International Journal of Obesity 26 (suppl 2): S1-S2 (2002). 126. Dulloo AG. A sympathetic defense against obesity Science 297: 780-781 (2002). 127. Dulloo AG and Montani JP. Obesity in Parkinson’s disease patient on electrotherapy: collateral damage, adiposity rebound or secular trends ? British Journal of Nutrition 93: 417-419 (2005) 15. 128. Dulloo AG , antic V, Yang Z, Montani JP. Propellers of growth trajectories to obesity and the metabolic syndrome. International Journal of Obesity 30: S1-S3(2006) 129. Dulloo AG. Suppressed thermogenesis as a cause for resistance to slimming and obesity rebound. International Journal of Obesity 31:201-3 (2007). 130. Dulloo AG, Yang Z, Montani JP. Dysfunctional foods in pathogenesis of obesity and metabolic syndrome. Int J Obes (Lond). 32 (Suppl 6):S1-3 (2008) 131. Dulloo AG. Adipose Tissue Plasticity in catch-up growth trajectories to metabolic syndrome: Hyperplastic versus hypertrophic catch-up fat. Diabetes. 2009;58:1037-9. -------------------International Conferences/Symposiums/workshops (2005-2010) as Invited Speaker / Contributor Instituto Juan March de Estudios Investigations International Meeting: Madrid, 4-6 April 2005 Workshop: Uncoupling proteins: current status and therapeurtic prospects Specific contribution:UCPs as modulators of thermogenesis: what are the physiological issues ? Childhood Obesity Symposium: from basic knowledge to clinical practice: Verbania, 15-16 April 2005 Specific contribution: Adipose specific control of thermogenesis in weight regulation: a link between catch-up growth and later diabesity. Small for Gestational age (SGA) meeting 2005: A satellite of the ESPE/LWPES 7th Joint meeting in lyon Symposium: SGA 2005: Understanding the biology and therapeutic consequences, Montreux, 18-20 September 2005 Specific contribution: Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes catch-up growth towards insulin resistance and obesity 3rd Fribourg Obesity Research Conference, Fribourg, September 2005 Symposium:‘Growing towards obesity and metabolic syndrome: from a perspective of molecularphysiology and nutrition’ Specific contribution: Catch-up growth as a determinant of metabolic syndrome: Why and how ? 4th International Symposium on Obesity and Hypertension (ISOH’05), Berlin October 27-29, 2005 Specific contribution: The thrifty ‘catch-up fat’ phenotype during weight fluctuations: its impact on insulin sensitivity and cardiovascular risks. 1st Symposium on Lipid and Membrane Biology, Graz, Austria (March 16-18) Symposium: Lipotoxicity Specific contribution: How does skeletal muscle protect itself against lipotoxicity ? 16. 10th International Congress on Obesity, Sydney Australia (3-8 September 2006) Symposium: Energy utilization by skeletal muscle Specific contribution: Adaptive thermogenesis and substrate cycling in skeletal muscle 10th International Congress on Obesity, Sydney Australia (3-8 September 2006) State-of-the- art lecture: Neurohormonal control of thermogenesis by adipokines 9th Annual Frontiers in Research Lectures, University of Ottawa, (November 15th, 2006) Theme: Weighty Issues Specific contribution: Weight fluctuations: Impact on metabolic susceptibility to obesity and metabolic syndrome International workshop on Catechins: Mechanisms of Action, Colworth, UK (March 2007) Organised by Unilever Ltd Specific contribution : Catechins-Caffeine-Catecholaminesinteractions in thermogenic stimulation 13th European Congress of Obesity , Budapest, Hungary (May 2007) Symposium: Autonomic control of metabolism Specific contribution: Autonomic control of thermogenesis The Obesity Society Annual Scientific Meeting –NAASO 2007, New Orleans (October 2007) Symposium: Energy Expenditure: Thermogenesis vs. Exercise Specific contribution: Deficits in thermogenesis as a cause of obesity Recent Advances and Controversies in the Measurement of Energy Metabolism, Denver, (Feb. 2008) Plenary session: Uncoupling, Substrate Cycling, and Tissue Specific Metabolism Specific contribution: The impact of substrate cycling on measurements of substrate oxidation and fuel utilization European Congress on Obesity – ECO 2009 Geneva (May 2008) Pre-congress satellite symposium: Adipose-muscle crosstalks in pathogenesis of metabolic syndrome: building bridges between molecular biology and integrative physiology Specific contribution: Adipose-muscle crosstalks: from an historical & evolutionary perspective. International Society of Antioxidant in Nutrition & Health ISANH-2008 – Berlin June 2008) Symposium: Slimming ingredients Specific contribution: Role of adipose and muscle thermogenesis in weight control 10th Benjamin Franklin / Lafayette Seminar – Fréjus, France (June 2009) Symposium: Energy balance and substrate metabolism Specific contribution: Pathways from weight fluctuations to obesity: Issues from a perspective of body composition autoregulation 31st European Society for parenteral & Enteral Nutrition (ESPEN) Congress, Vienna, Austria (August 2009) Symposium: Childhood obesity Specific contribution: Catch-up growth: catch-up of lean tissue or catch-up fat ? 5th Fribourg Obesity Research Conference, Fribourg, September 2009 Symposium:‘Phenotyping for early predictors of obesity and metabolic syndrome Specific contribution: Hazardous fat in the human body: what are they and how do we measure them ? 17. The Obesity Society – Annual Scientific Meeting – Washington DC, USA (October 2009) Symposium: Energy restriction models and metabolic outcome Specific contribution: Molecular mechanisms underlying the thrifty ‘Catch-up’fat phenotype 11th International Congress on Obesity – Stockholm, Sweden (July 2010) Symposium: Energy metabolism Specific contribution: Energy balance in the weight-reduced state