CURRICULUM VITAE:

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CURRICULUM VITAE

Jan Nedergaard

CURRICULUM VITAE: Jan Nedergaard

Professional address: The Wenner-Gren Institute. Stockholm University

SE-106 91 Stockholm, Sweden

PhD-degree : 1980: The Wenner-Gren Institute, Stockholm University,

PhD in Zoological Physiology

Control of fatty acid utilization in brown adipose tissue Thesis:

Docent :

Current position :

1982: Stockholm University, in Zoological Physiology

Full Professor in Physiology, The Wenner-Gren Institute, Stockholm

University, since 1999

Previous positions : 1994-1998: Professor, The Wenner-Gren Institute, Stockhol University

1984-1994: Associate Professor, The Wenner-Gren Institute,

Stockholm University

1981-1984: Assistant Professor, The Wenner-Gren Institute,

Stockholm University

1981 and 1985, 6 months at each occasion Parental leaves :

Current research activities: The physiology of thermogenesis

Awarded doctorates: Since 1984, 17 PhD:s (main supervisor)

Since 1984, 14 PhD:s (co-supervisor)

Currently supervisor for 4 PhD-students

Postdoc working or worked in Cannon/Nedergaard’s research group: 26, since 1983

Major running scientific grants:

2011-2013 PI VR-NT 3 300 kkr

2009-2011 PI VR-M 1 200 kkr

2008-2012 Co-PI EU-ADAPT 445 k€

2009-2011 Co-PI Mitotech 1 250 kkr

2011 PI Metabolic Solutions 900 kkr

National and international assignments of importance :

Since 2003: Member of the National Committee of Physiology, Pharmacology and

Neurobiology; Secretary of the Committee since 2008

2003-2008: Dean of the Subfaculty of Biology, Stockholm University

2003-2008: Chairman of the Faculty Appointments Committee;

Member of the Committee 1990-1993

1993-2002: Chairman of the Faculty Docent Committee

1989-1995: Member of the Biology Committee of the Swedish Natural Science Research

Council

CURRICULUM VITAE

Jan Nedergaard

Bibliometric data: about 150 primary articles and of about 100 review articles and book chapters. H-index 45. Number of citations: 6879

Total citations during 2010: 744

Ten selected publications (from the last 10 years):

Petrovic, N., Walden, T.B., Shabalina, I.G., Timmons, J.A., Cannon, B. and Nedergaard, J. (2010) Chronic activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent,

UCP1-containing adipocytes molecularly distinct from classical brown adipocytes. J. Biol. Chem. 285, 7153-7164.

Feldmann, H.M., Golozoubova, V., Cannon, B. and Nedergaard, J. (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab.

9, 203-209.

Timmons, J.A., Wennmalm, K., Larsson, O., Walden, T.B., Lassmann, T., Petrovic, N., Hamilton, D.L., Gimeno, R.

E., Wahlestedt, C., Baar, K., Nedergaard, J. and Cannon, B. (2007) Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc. Natl. Acad. Sci. USA 104, 4401-4406.

Nedergaard, J., Bengtsson, T. and Cannon, B. (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol . 293, E444-E452.

Golozoubova, V., Cannon, B. and Nedergaard, J. (2006) UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. Am. J. Physiol .

291, E350-E357

Shabalina, I.G., Jacobsson, A., Cannon, B. and Nedergaard, J. (2004) Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids . J. Biol. Chem. 279,

38236-38248.

Cannon, B. and Nedergaard, J. (2004) Brown adipose tissue: function and physiological significance. Physiol. Rev .

84, 277-359.

Golozoubova, V., Hohtola, E., Matthias, A., Jacobsson, A., Cannon, B. and Nedergaard, J. (2001) Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J . 15, 2048-2050.

Matthias, A., Ohlson, K.B.E., Fredriksson, J.M., Jacobsson, A., Nedergaard, J. and Cannon, B. (2000) Thermogenic responses in brown-fat cells are fully UCP1-dependent. UCP2 or UCP3 cannot substitute for UCP1 in adrenergically or fatty-acid induced thermogenesis. J. Biol. Chem . 275, 25073-25081.

Fredriksson, J.M., Lindquist, J.M., Bronnikov, G.E. and Nedergaard, J. (2000) Norepinephrine induces vascular

-adrenoceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. J. Biol. Chem.

275, 13802-13811.

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