Standard Operating Procedure
Chemical name/class:
CAS #: 10540-29-1
Room #:
1. Circumstances of Use:
2. Potential Hazards:
 Tamoxifen has been classified as carcinogenic to human by IARC and NTP.
 LD50 Oral: 4100 mg/kg (rat)
 Tamoxifen is a toxic substance.
 Tamoxifen exposure routes: inhalation, ingestion, skin contact, eye contact
 Tamoxifen is classified as a reproductive system toxin/female and a possible development toxin.
 Consult your (Safety Data Sheet (SDS) for additional information.
3. Engineering Controls:
 All operations involving tamoxifen (powder, granules, and solution) must be conducted in a certified ducted
Biological Safety Cabinet or a properly operating and certified chemical fume hood.
 If using tamoxifen powdered form outside of a fume hood or BSCs, a full-face particle respirator type N100
must be worn. In order to wear a full-face particle respirator, one must be medically cleared, fit tested and
trained. Contact Safety Office to schedule fit testing.
 Syringes used for tamoxifen injection should be safety engineered type (self-sheathing syringes, luer-lock
syringes, etc.).
 Safety Shower and Emergency eyewash should be easily accessible within the immediate work environment
in areas where
4. Work Practice Controls:
 All tamoxifen work must be conducted in a Type II ducted Biosafety Cabinet (BSC). Alternatively, a certified
operating chemical fume hood can be used if approved by the IBC.
 For any work conducted outside of a ducted BSC or fume hood, a full-face particle respirator type N100 must
be used. Contact Safety Office to be fit tested.
 Mice will be housed on absorbent paper for 24 hours post injection after which the absorbent paper is
disposed in a yellow Chemotherapy Waste bag.
 Work surface and equipment will be cleaned by a detergent solution, and rinsed by water. In cases where
infectious materials were used, a disinfectant will be used after drug decontamination.
5. Personal protective equipment (PPE):
 Use double pair of nitrile laboratory gloves and a fully buttoned lab coat with sleeves extending to the wrists
should be worn when handling the drug.
 If splashes may occur, wear goggles and a face shield. Otherwise, wear standard laboratory safety glasses.
 In cases where the arms or torso may be exposed to liquid suspensions or dry particles, wear Tyvek sleeves
and/or gowns (or other air-tight non-woven textile).
6. Transportation and Storage:
 Powder and solutions should be in a tightly closed shatter-resistant containers during transportation and
storage. Secondary containment is advised.
 It should be stored in a cool, dry place.
Keep a chemo spill kit on hand in case of spill
7. Waste Disposal:
 Collect Tamoxifen solutions and solid waste in a container separate from other hazardous waste. Use a
Hazardous Waste sticker and label the bottle with the full chemical name. Call Safety Office for pick-up.
8. Exposures/Unintended contact:
For chemical exposure:
 Flush exposed eyes or skin with water for at least 15 minutes, then seek medical attention.
 If inhaled, remove victim from the contaminated area, then seek medical attention.
 Skin/Body contact: remove clothing and rinse body in emergency shower for minimum 15 minutes. Seek medical
 Call 41 from a campus phone to request emergency assistance. Contact Business Health at for exposure-related
 Report any work-related injury or illness to Business Health
 Contact the Safety Office for medical advice on occupational chemical exposures.
9. Spill Procedure:
 For spills of liquid suspensions, absorb the spilled material with paper towels, absorbent pads, or vermiculite
etc. Wait 10 minutes and wash spill area with soap and water. Place all spill materials in a double lined yellow
plastic chemo waste bag.
 For solid spills wet paper towels or absorbent pads with water and gently place on top of the powder to avoid
dust creation. Wipe up area and follow instruction above for liquid spill.
 Use tweezers to pick up broken glass and place in red sharps container.
 Medium to large spills: Evacuate the room or laboratory immediately. Notify the PI and call the Safety Office for
assistance. Post signs at the entrance and exit to notify others of the spill.
10. Training of personnel:
All personnel are required to complete the online training sessions Hazardous Drugs, Biological Safety, Biological
Waste, Chemical Hygiene and Hazardous Chemical Waste. All personnel shall read and fully adhere to this SOP for
safe handling of drug, and shall document that they have read these documents by signing and dating the SOP and
waste procedures.
“I have read and understand this SOP. I agree to fully adhere to its requirements.”